LIBRARY
Click the tabs below to explore a few of our most popular applications for our suite of HALO products.
RNAscope Image Analysis Using HALO® and HALO AI™
Quantification and Characterization of Glomeruli Across Diverse Stains Using HALO AI™
Results from CAMELYON17: Using HALO AI to Identify and Stage Breast Cancer Metastases
Quantifying Immune Cells in the Tumor Microenvironment Using HALO® Spatial Analysis Tools
CUSTOMER PUBLICATIONS
Indica Labs’ customers perform quantitative image analysis on research areas as diverse as immuno-oncology, toxicology, metabolism, and neuroscience. Check out the latest publications from our customers with HALO image analysis software! Click the navigation bar to sort according to Application, Journal, HALO Module, and more.
Title | Authors | Year | Journal | Application | HALO Modules | Product |
---|---|---|---|---|---|---|
Stem cellderived CAR T cells traffic to HIV reservoirs in macaques | Barber-Axthelm IM, Barber-Axthelm V, Sze KY, Zhen A, Suryawanshi GW, Chen ISY, Zack JA, Kitchen SG, Kiem H-P, Peterson CW | 2021 | JCI Insight | Immunology, Infectious Disease | Area Quantification | HALO |
IL-1-driven stromal-neutrophil interaction in deep ulcers defines a pathotype of therapy non-responsive inflammatory bowel disease | Friedrich M, Pohin M, Jackson MA, Korsunsky I, Bullers S, Rue-Albrecht K, Christoforidou Z, Sathananthan D, Ravindran R, Peres RS, Sharpe H, Wei K, Watts GFM, Mann EH, Geremia A, Thomas T, Attar M, Oxford IBD Cohort Investigators, Roche Fibroblast Network Consortium, McCuaig S, Thomas L, Collantes E, Uhlig HH, Sansom S, Easton A, Raychaudhuri S, Travis SP, Powrie FM | 2021 | bioRxiv | Immunology | Cytonuclear | HALO |
Highly Fermentable Fiber Alters Fecal Microbiota and Mitigates Swine Dysentery Induced by Brachyspira hyodysenteriae | Helm ET, Gabler NK, Burrough ER | 2021 | Animals | Infectious Disease | Cytonuclear | HALO |
Vascular endothelial ERp72 is involved in the inflammatory response in a rat model of skeletal muscle injury | Khalaf NB, Al-Mehatab D, Fathallah DM | 2021 | Medicine Reports | Immunology | Cytonuclear | HALO |
Lipid Source and Peroxidation Status Alter Immune Cell Recruitment in Broiler Chicken Ileum | Fries-Craft KA, Meyer MM, Lindblom SC, Kerr BJ, Bobeck EA | 2021 | The Journal of Nutrition | Immunology | ISH/FISH | HALO |
Frontotemporal lobar degeneration proteinopathies have disparate microscopic patterns of white and grey matter pathology | Giannini LAA, Peterson C, Ohm D, Xie SX, McMillan CT, Raskovsky K, Massimo L, Suh E, Van Deerlin VM, Wolk DA, Trojanowski JQ, Lee EB, Grossman M, Irwin DJ | 2021 | Acta Neuropathologica Communications | Neuroscience | Area Quantification | HALO |
Fasting reverses drug-resistance in hepatocellular carcinoma through p53-dependent metabolic synergism | Krstic J, Reinisch I, Schindlmaier K, Galhuber M, Berger N, Kupper N, Moyschewitz E, Auer M, Michenthaler H, Nössing C, Depaoli MR, Ramadani-Muja J, Stryeck S, Pichler M, Rinner B, Deutsch AJA, Reinisch A, Madl T, Chiozzi RZ, Heck AJR, Huch M, Malli R, Prokesch A | 2021 | bioRxiv | Oncology | Classifier, Cytonuclear | HALO |
Recruitment of KRAS downstream target ARL4C to membrane protrusions accelerates pancreatic cancer cell invasion | Harada A, Matsumoto S, Yasumizu Y, Akama T, Eguchi H, Kikuchi A | 2021 | bioRxiv | Oncology | Area Quantification | HALO |
Potential role of M2 TAMs around lymphatic vessels during lymphatic invasion in papillary thyroid carcinoma | Kabasawa T, Ohe R, Aung NY, Urano Y, Kitaoka T, Tamazawa N, Utsunomiya A, Yamakawa M | 2021 | Scientific Reports | Oncology | Area Quantification | HALO |
Amylin deposition activates HIF1? and 6-phosphofructo-2-kinase/fructose-2, 6-biphosphatase 3 (PFKFB3) signaling in failing hearts of non-human primates | Liu M, Li N, Qu C, Gao Y, Wu L, Hu LG | 2021 | Communications Biology | Metabolism | Area Quantification, Cytonuclear | HALO |
BMP pathway antagonism by Grem1 regulates epithelial cell fate in intestinal regeneration | Koppens MAJ, Davis H, Valbuena GN, Mulholland EJ, Nasreddin N, Colombe M, Antanaviciute A, Biswas S, Friedrich M, Lee L, Oxford IBD cohort investigators, Wang LM, Koelzer VH, East JE, Simmons A, Winton DJ, Leedham SJ | 2021 | bioRxiv | Gastroenterology | Area Quantification | HALO |
A distinct repertoire of cancer-associated fibroblasts is enriched in cribriform prostate cancer | Hesterberg AB, Rios BL, Wolf EM, Tubbs C, Wong HY, Schaffer KR, Lotan TL, Giannico GA, Gordetsky JB, Hurley PJ | 2021 | Journal of Pathology:Clinical Research | Oncology | Classifier, ISH/FISH | HALO |
Dystrophic microglia are associated with neurodegenerative disease and not healthy aging in the human brain | Shahidehpour RK, Higdon RE, Crawford NG, Neltner JH, Ighodaro ET, Patel E, Price D, Nelson PT, Bachstetter AD | 2021 | Neurobiology of Aging | Neuroscience | Area Quantification | HALO |
Inhibition of Hedgehog signaling alters fibroblast composition in pancreatic cancer | Steele NG, Biffi G, Kemp SB, Zhang Y, Drouillard D, Syu L-J, Hao Y, Oni TE, Brosnan E, Elyada E, Doshi A, Hansma C, Espinoza C, Abbas A, The S, Irizarry-Negron VM, Halbrook CJ, Franks N, Hoffman M, Brown KL, Carpenter ES, Nwosu ZC, Johnson C, Lima F, Anderson MA, Park Y, Crawford HC, Lyssiotis CA, Frankel TF, Rao A, Bednar F, Dlugosz AA, Preall J, Tuveson DA, Allen B, di Magliano MP | 2021 | Clinical Cancer Research | Oncology | Area Quantification | HALO |
Locally confined IFN? production by CD4+ T cells provides niches for murine cytomegalovirus 4 replication in the salivary gland | Oderbolz J, Zangger N, Zimmerman L, Sandu I, Starruß J, Graw F, Oxenius A | 2021 | bioRxiv | Classifier, Spatial Analysis, Highplex FL | HALO | |
Kaiso (ZBTB33) subcellular partitioning functionally links LC3A/B, the tumor microenvironment, and breast cancer survival | Singhal SK, Byun JS, Park S, Yan T, Yancey R, Caban A, Hernandez SG, Hewitt SM, Boisvert H, Hennek S, Bobrow M, Ahmed SU, White J, Yates C, Aukerman A, Vanguri R, Bareja R, Lenci R, Farré PL, De Siervi A, Nápoles AM, Vohra N, Gardner K | 2021 | Communications Biology | Oncology | Cytonuclear, TMA | HALO |
Deep Learning-Based Annotation Transfer between Molecular Imaging Modalities: An Automated Workflow for Multimodal Data Integration | Race AM, Sutton D, Hamm G, Maglennon G, Morton JP, Strittmatter N, Campbell A, Sansom OJ, Wang Y, Barry ST, Takáts Z, Goodwin RJA, Bunch J | 2021 | Analytical Chemistry | Oncology | HALO AI | |
Integrative molecular characterization of sarcomatoid and rhabdoid renal cell carcinoma | Bakouny Z, Braun DA, Shukla SA, Pan W, Gao X, Hou Y, Flaifel A, Tang S, Bosma-Moody A, He MX, Vokes N, Nyman J, Xie W, Nassar AH, Alaiwi SA, Flippot R, Bouchard G, Steinharter JA, Nuzzo PV, Ficial M, SantAngelo M, Forman J, Berchuck JE, Dudani S, Bi K, Park J, Camp S, Sticco-Ivins M, Hirsch L, Baca SC, Wind-Rotolo M, Ross-Macdonald P, Sun M, Mary Lee G-SM, Chang SL, Wei XX, McGregor BA, Harshman LC, Genovese G, Ellis L, Pomerantz M, Hirsch MS, Freedman ML, Atkins MB, Wu CJ, Ho TH, Linehan WM, McDermott DF, Heng DYC, Viswanathan SR, Signoretti S, Van Allen EM, Choueiri TK | 2021 | Nature Communications | Oncology | Highplex FL | HALO |
IgA transcytosis and antigen recognition govern ovarian cancer immunity | Biswas S, Mandal G, Payne KK, Anadon CM, Gatenbee CD, Chaurio RA, Costich TL, Moran C, Harro CM, Rigolizzo KE, Mine JA, Trillo-Tinoco J, Sasamoto N, Terry KL, Marchion D, Buras A, Wenham RM, Yu X, Townsend MK, Tworoger SS, Rodriguez CR, Anderson AR, Conejo-Garcia JR | 2021 | Nature | Immuno-oncology | Highplex FL | HALO |
Characterization of Macrophages and Osteoclasts in the Osteosarcoma Tumor Microenvironment at Diagnosis: New Perspective for Osteosarcoma Treatment? | Gomez-Brouchet A, Gilhodes J, Van Acker N, Brion R, Bouvier C, Assemat P, Gaspar N, Aubert S, Guinebretiere J-M, Marie B, Larousserie F, Entz-Werlé N, de Pinieux G, Mascard E, Gouin F, Brousset P, Tabone M-D, Jimenez M, Le Deley M-C, Blay J-Y, Brugieres L , Piperno-Neumann S, Rédini F | 2021 | Cancers | Immuno-oncology | Highplex FL | HALO |
CD30+OX40+ Treg is associated with improved overall survival in colorectal cancer | Lam JH, Hong M, Koo S-L, Chua CWL, Lim KL, Wee F, Wan WK, Leow WQ, Yeo JG, Tan IBH, Yeong J, Lim TKH, Lim TS | 2021 | Cancer Immunology, Immunotherapy | Immuno-oncology | Highplex FL | HALO |
Sustained Helicobacter pylori infection accelerates gastric dysplasia in a mouse model | OBrien VP, Koehne AL, Dubrulle J, Rodriguez AE, Leverich CK, Kong VP, Campbell JS, Pierce RH, Goldenring JR, Choi E, Salama NR | 2021 | Life Science Alliance | Immuno-oncology | Highplex FL | HALO |
A feasibility study of combined epigenetic and vaccine therapy in advanced colorectal cancer with pharmacodynamic endpoint | Bever KM, Thomas DL, Zhang J, Rivera EAD, Rosner GL, Zhu Q, Nauroth JM, Christmas B, Thompson ED, Anders RA, Judkins C, Liu M, Jaffee EM, Ahuja N, Zheng L, Azad NS | 2021 | Clinical Epigenetics | Oncology | Immune, Membrane | HALO |
CD8+ T cells fail to limit SIV reactivation following ART withdrawal until after viral amplification | Okoye AA, Duell DD, Fukazawa Y, Varco-Merth B, Marenco A, Behrens H, Chaunzwa TM, Selseth AN, Gilbride RM, Shao J, Edlefsen PT, Geleziunas R, Pinkevych M, Davenport MP, Busman-Sahay K, Nekorchuk MD, Park H, Smedley JV, Axthelm MK, Estes JD, Hansen SG, Keele BF, Lifson JD, Picker LJ | 2021 | The Journal of Clinical Investigation | Immunology, Infectious Disease | ISH/FISH | HALO |
The effect of cyfluthrin on testis inhibin B in rats and the intervention of Lycium barbarum polysaccharide | Guo X, Xie Y-X, Guo C, Wei J-L, Yang H-F | 2021 | Molecular & Cellular Toxicology | Toxicology | Multiplex IHC | HALO |
Cooperative targeting of immunotherapy-resistant melanoma and lung cancer by an AXL-targeting antibody-drug conjugate and immune checkpoint blockade | Boshuizen J, Pencheva N, Krijgsman O, Altimari DD, Castro PG, de Bruijn B, Ligtenberg MA, den Heuvel EG, Vredevoogd DW, Song J-Y, Visser N, Apriamashvili G, Janmaat ML, Plantinga TS, Franken P, Houtkamp M, Lingnau A, Jure-Kunkel M, Peeper DS | 2021 | Cancer Research | Immuno-oncology | HALO | |
ATP-binding cassette transporters restrict drug delivery and efficacy against brain tumors even when blood-brain barrier integrity is lost | de Gooijer MC, Kemper EM, Buil LCM, Citirikkaya CH, Buckle T, Beijnen JH, van Tellingen O | 2021 | Cell Reports Medicine | Oncology | HALO | |
The amino acid transporter SLC7A5 is required for efficient growth of KRAS-mutant colorectal cancer | Najumudeen AK, Ceteci F, Fey SK, Hamm G, Steven RT, Hall H, Nikula CJ, Dexter A, Murta T, Race AM, Sumpton D, Vlahov N, Gay DM, Knight JRP, Jackstadt R, Leach JDG, Ridgway RA, Johnson ER, Nixon C, Hedley A, Gilroy K, Clark W, Malla SB, Dunne PD, Rodriguez-Blanco G, Critchlow SE, Mrowinska A, Malviya G, Solovyev D, Brown G, Lewis DY, Mackay GM, Strathdee D, Tardito S, Gottlieb E, CRUK Rosetta Grand Challenge Consortium, Takats Z, Barry ST, Goodwin RJA, Bunch J, Bushell M, Campbell AD, Sansom OJ | 2021 | Nature Genetics | Oncology | HALO | |
Single-cell analysis shows that adipose tissue of persons with both HIV and diabetes is enriched for clonal, cytotoxic, and CMV-specific CD4+ T cells | Wanjalla CN, McDonnell WY, Ram R, Chopra A, Gangula R, Leary S, Mashayekhi M, Simmons JD, Warren CM, Bailin S, Gabriel CL, Cuo L, Furch BD, Lima MC, Woodward BO, Hannah L, Pilkinton MA, Fuller DT, Kawai K, Virmani R, Finn AV, Hasty AH, Mallal SA, Kalams SA, Koethe JR | 2021 | Cell Reports Medicine | Immunology, Metabolism | HALO | |
Acute Respiratory Distress in Aged, SARS-CoV-2 Infected African Green Monkeys but not Rhesus Macaques | Blair RV, Vaccari M, Doyle-Meyers LA, Roy CJ, Russell-Lodrigue K, Fahlberg M, Monjure CJ, Beddingfield B, Plante KS, Plante JA, Weaver SC, Qin X, Midkiff CC, Lehmicke G, Golden N, Threeton B, Penney T, Allers C, Barnes MB, Pattison M, Datta PK, Maness NJ, Birnbaum A, Fischer T, Bohm RP, Rappaport J | 2020 | The American Journal of Pathology | Infectious Disease | Classifier | HALO |
Association of COVID-19 inflammation with activation of the C5aC5aR1 axis | Carvelli J, Demaria O, Vely F, Batista L, Benmansour NC, Fares J, Carpentier S, Thibult M-L, Morel A, Andre P, Represa A, Piperoglou C, Cordier PY, Le Dault E, Guervilly C, Simone P, Gainnier M, Morel Y, Ebbo M, Schleinitz N, Vivier E | 2020 | Nature | Immunology | Cytonuclear | HALO |
Impact of Preanalytical Factors During Histology Processing on Section Suitability for Digital Image Analysis | Chlipala EA, Butters M, Brous M, Fortin JS, Archuletta R, Copeland K, Bolon B | 2020 | Toxicologic Pathology | Toxicology | Area Quantification, Cytonuclear | HALO |
Tumor vessel normalization, immuno-stimulatory reprogramming, and improved survival in glioblastoma with combined inhibition of PD-1, angiopoietin-2, and VEGF | Di Tacchio M, Macas J, Weissenberger J, Sommer K, Bähr O, Steinbach JP, Senft C, Seifert V, Glas M, Herrlinger U, Krex D, Meinhardt M, Weyerbrock A, Timmer M, Goldbrunner R, Deckert M, Scheel AH, Büttner R, Grauer OM, Schittenhelm J, Tabatabai G, Harter PN, Guenther S, Devraj K, Plate KH, Reiss Y | 2020 | Cancer Immunology Research | Oncology, Immuno-oncology | Classifier, Cytonuclear | HALO |
Immune cell landscaping reveals a protective role for regulatory T cells during kidney injury and fibrosis | do Valle Duraes F, Lafont A, Biebel M, Martin K, Darribat K, Cuttat R, Waldt A, Naumann U, Wieczorek G, Gaulis S, Pfister S, Mertz KD, Li J, Roma G, Warncke M | 2020 | JCI Insight | Immunology | Area Quantification, Cytonuclear | HALO |
The prevalence and prognostic significance of estrogen receptor beta expression in non-small cell lung cancer | Enwere EK, Dean ML, Li H, D'Silva A, Bebb DG | 2020 | Translational Lung Cancer Research | Oncology | Cytonuclear, TMA | HALO |
Dendritic Cell Paucity Leads to Dysfunctional Immune Surveillance in Pancreatic Cancer | Hedge S, Krisnawan VE, Herzog BH, Zuo C, Breden MA, Knolhoff BL, Hogg GD, Tang JP, Baer JM, Mpoy C, Lee KB, Alexander KA, Rogers BE, Murphy KM, Hawkins WG, Fields RC, DeSelm CJ, Schwarz JK, DeNardo DG | 2020 | Cancer Cell | Oncology, Immuno-oncology | Area Quantification, Cytonuclear, Immune | HALO |
Periconceptional exposure to lopinavir, but not darunavir, impairs decidualization: a potential mechanism leading to poor birth outcomes in HIV-positive pregnancies | Kala S, Dunk C, Acosta S, Serghides L | 2020 | Human Reproduction | Infectious Disease | Cytonuclear | HALO |
Three-dimensional culture models mimic colon cancer heterogeneity induced by different microenvironments | Kawai S, Yamazaki M, Shibuya K, Yamazaki M, Fujji E, Nakano K, Suzuki M | 2020 | Scientific Reports | Oncology | Cytonuclear | HALO |
Epithelial-mesenchymal transition of absorptive enterocytes and depletion of Peyer's patch M cells after PEDV infection | Chen Y-M, Helm ET, Groeltz-Thrush, Gabler NK, Burrough ER | 2020 | Virology | Immunology | Area Quantification | HALO |
Imaging breast cancer using hyperpolarized carbon-13 MRI | Gallagher FA, Woitek R, McLean MA, Gill AB, Garcia RM, Provenzano E, Riemer F, Kaggie J, Chhabra A, Ursprung S, Grist JT, Daniels CJ, Zaccagna F, Laurent M-C, Locke M, Hilborne S, Frary A, Torheim T, Boursnell C, Schiller A, Patterson I, Slough R, Carmo B, Kane J, Biggs H, Harrison E, Deen SS, Patterson A, Lanz T, Kingsbury Z, Ross M, Basu B, Baird R, Lomas DJ, Sala E, Wason J, Rueda OM, Chin S-F, Wilkinson IB, Graves MJ, Abraham JE, Gilbert FJ, Caldas C, Brindle KM | 2020 | Proceedings of the National Academy of Sciences | Oncology | Area Quantification | HALO |
Conformation-selective tau monoclonal antibodies inhibit tau pathology in primary neurons and a mouse model of Alzheimers disease | Gibbons GS, Kim S-J, Wu Q, Riddle DM, Leight SN, Changolkar L, Xu H, Meymand ES, O'Reilly M, Zhang B, Brunden KR, Trojanowski JQ, Lee VMY | 2020 | Molecular Neurodegeneration | Neuroscience | Area Quantification | HALO |
TGF?-blockade uncovers stromal plasticity in tumors by revealing the existence of a subset of interferon-licensed fibroblasts | Grauel AL, Nguyen B, Ruddy D, Laszewski T, Schwartz S, Chang J, Chen J, Piquet M, Pelletier M, Yan Z, Kirkpatrick ND, Wu J, deWeck A, Riester M, Hims M, Geyer FC, Wagner J, MacIsaac K, Deeds J, Diwanji R, Jayaraman P, Yu Y, Simmons Q, Weng S, Raza A, Minie B, Dostalek M, Chikkegowda P, Ruda V, Iartchouk O, Chen N, Thierry R, Zhou J, Pruteanu-Malinici I, Fabre C, Engelman JA, Dranoff G, Cremasco V | 2020 | Nature Communications | Oncology | Area Quantification | HALO |
Ex-vivo delivery of monoclonal antibody (Rituximab) to treat human donor lungs prior to transplantation | Ku TJY, Ribeiero RVP, Ferreira VH, Galasso M, Keshavjee S, Kumar D, Cypel M, Humar A | 2020 | EBioMedicine | Other | Classifier, Cytonuclear | HALO |
Transmission of tauopathy strains is independent of their isoform composition | He Z, McBride JD, Zu, Changolkar L, Kim S, Zhang B, Narasimhan S, Gibbons GS, Kozak M, Schellenberg GD, Trrojanowski JQ, Lee VM-Y | 2020 | Nature Communications | Neuroscience | Area Quantification | HALO |
Human cardiac fibroblasts expressing VCAM1 improve heart function in postinfarct heart failure rat models by stimulating lymphangiogenesis | Iwamiya T, Segnard B-D, Matsuoka Y, Imamura T | 2020 | PLOS One | Myology | Area Quantification | HALO |
Environmental contaminant ammonia triggers epithelial-to-mesenchymal transition-mediated jejunal fibrosis with the disassembly of epithelial cell-cell contacts in chicken | Jing H, Wang S, Wang Y, Shen N, Gao X-J | 2020 | ScienceTotalEnvrt | Toxicology | Area Quantification | HALO |
Cholinergic receptors on intestine cells of Ascaris suum and activation of nAChRs by levamisole | McHugh M, Williams P, Verma S, Powell-Coffman JA, Robertson AP, Martin RJ | 2020 | International Journal for Parasitology: Drugs and Drug Resistance | Gastroenterology, Infectious Disease | Area Quantification | HALO |
Adult onset pan-neuronal human tau tubulin kinase 1 expression causes severe cerebellar neurodegeneration in mice | McMillan P, Wheeler J, Gatlin RE, Taylor L, Strovas T, Baum M, Bird TD, Latimer C, Keene CD, Kraemer BC, Liachko NF | 2020 | Acta Neuropathologica Communications | Neuroscience | Area Quantification | HALO |
Spatial immune profiling of the colorectal tumor microenvironment predicts good outcome in stage II patients | Nearchou IP, Gwyther BM, Georgiakakis ECT, Gavriel CG, Kajiwara Y, Ueno H, Harrison DJ, Caie PD | 2020 | Digital Medicine | Immuno-oncology | Classifier, Area Quantification, Spatial Analysis | HALO |
11? hydroxysteroid dehydrogenase 1: a new marker for predicting response to immune-checkpoint blockade therapy in non-small-cell lung carcinoma | Saito R, Miki Y, Abe T, Miyauchi E, Abe J, Nanamiya R, Inoue C, Sato I, Sasano H | 2020 | British Journal of Cancer | Immuno-oncology | Area Quantification | HALO |
Clinicopathological significance of endoplasmic reticulum stress proteins in ovarian carcinoma | Samanta S, Tamura S, Dubeau L, Mhawech-Fauceglia P, Miyagi Y, Kato H, Lieberman R, Buckanovich RJ, Lin YG, Neamati N | 2020 | Scientific Reports | Oncology | Area Quantification | HALO |
Prognostic value of tumor-inltrating immune cells in primary colorectal cancer and metastases | Martin SZ, Tagscherer KE, Deckert S, Horst D, Moehler M, Lang H, Roth W | 2020 | *Pre-Print | Immuno-oncology | Classifier, Cytonuclear | HALO |
Implementation of PD-L1 22C3 IHC pharmDxTM in Cell Block Preparations of Lung Cancer: Concordance with Surgical Resections and Technical Validation of CytoLyt® Prefixation | Lou SK, Ko HM, Kinoshita T, MacDonald S, Weiss J, Czarnecka-Kujawa K, Boerner SL, Yasufuku K, Tsao M-S, Schwock J | 2020 | Acta Cytologica | Oncology | Classifier, Membrane | HALO |
Immuno-Interface Score to Predict Outcome in Colorectal Cancer Independent of Microsatellite Instability Status | Nestarenkaite A, Fadhil W, Ramusson A, Susanti S, Hadjimichael E, Laurinaviciene A, Ilyas M, Laurinavicius A | 2020 | Cancers | Immuno-oncology | Classifier, Multiplex IHC | HALO |
Assessment of associations between clinical and immune microenvironmental factors and tumor mutation burden in resected nonsmall cell lung cancer by applying machine learning to whole-slide images | Ono A, Terada Y, Kawata T, Serizawa M, Isaka M, Kawabata T, Imai T, Mori K, Muramatsu K, Hayashi I, Kenmotsu H, Oshima K, Urakami K, Nagashima T, Kusuhara M, Akiyama Y, Sugino T, Ohde Y, Yamaguchi K, Takahashi T T | 2020 | Cancer Medicine | Classifier, Multiplex IHC, Serial Section | HALO | |
Prevalence of CD8+ cytotoxic lymphocytes in human neoplasms | Blessin NC, Spriestersbach P, Li W, Mandelkow T, Dum D, Simon R, Hube-Magg C, Lutz F, Viehweger F, Lennartz M, Fraune C, Nickelsen V, Fehrle W, Göbel C, Weidemann S, Clauditz T, Lebok P, Möller K, Steurer S, Izbicki JR, Sauter G, Minner S, Jacobsen F, Luebke AM, Büscheck F, Höflmayer D, Wilczak W, Burandt E, Hinsch A | 2020 | Cellular Oncology | Oncology, Immuno-oncology | Membrane, TMA | HALO |
Persistence of adoptively transferred T cells with a kinetically engineered IL-2 receptor agonist | Parisi G, Saco JD, Salazar FB, Tsoi J, Krystofinski P, Puig-Saus C, Zhang R, Zhou J, Cheung-Lau GC, Garcia AJ, Grasso CS, Tavaré R, Hu-Lieskovan S, Mackay S, Zalevsky J, Bernatchez C, Diab A, Wu AM , Comin-Anduix B, Charych D, Ribas A | 2020 | Nature Communications | Oncology, Immuno-oncology | Cytonuclear | HALO |
Mechanical regulation of glycolysis via cytoskeleton architecture | Park JS, Burckhardt CJ, Lazcano R, Solis LM, Isogai T, Li L, Chen CS, Gao B, Minna JD, Bachoo R, DeBerardinis RJ, Danuser G | 2020 | Nature | Oncology | Classifier, Cytonuclear, TMA | HALO |
Naproxen chemoprevention promotes immune activation in Lynch syndrome colorectal mucosa | Reyes-Uribe L, Wu W, Gelincik O, Bommi PV, Francisco-Cruz A, Solis LM, Lynch PM, Lim R, Stoffel EM, Kanth P, Samadder NJ, Mork ME, Taggart MW, Milne GL, Marnett LJ, Vornik L, Liu DD, Revuelta M, Chang K, You YN, Kopelovich L, Wistuba II, Lee JJ, Sei S, Shoemaker RH, Szabo E, Richmond E, Umar A, Perloff M, Brown PH, Lipkin SM, Vilar E | 2020 | Gut | Oncology | Classifier, Cytonuclear | HALO |
p53 is associated with high-risk and pinpoints TP53 missense mutations in mantle cell lymphoma | Rodrigues JM, Hassan M, Freiburghaus C, Eskelund CW, Geisler C, Raty R, Kolstad A, Sundstrom C, Glimelius I, Gronbaek K, Kwiecinska A, Porwit A, Jerkeman M, Ek S | 2020 | British Journal of Haematology | Oncology | Classifier, Cytonuclear | HALO |
RUNX1 is a driver of renal cell carcinoma correlating with clinical outcome | Rooney N, Mason SM, McDonald L, Däbritz HM, Campbell KJ, Hedley A, Howard S, Athineos D, Nixon C, Clark W, Leach JDG, Samsom OJ, Edwards J, Cameron ER, Blyth K | 2020 | Cancer Research | Oncology | Cytonuclear | HALO |
Analytical Performance of an Immunoprofiling Assay Based on RNA Models | Schillebeeckx I, Armstrong JR, Forys JT, Hiken J, Earls J, Flanagan KC, Cui T, Glasscock JI, Messina DN, Duncavage EJ | 2020 | The Journal of Molecular Diagnostics | Immunology | Cytonuclear | HALO |
Prognostic significance of mesothelin expression in colorectal cancer disclosed by area-specific four-point tissue microarrays | Shiraishi T, Shinto E, Nearchou IP, Tsuda H, Kajiwara Y, Einama T, Caie PD, Kishi Y, Ueno H | 2020 | Vichows Archiv | Oncology | Cytonuclear, TMA | HALO AI |
Prognostic and Predictive Value of Tumor-infiltrating Leukocytes and of Immune Checkpoint Molecules PD1 and PDL1 in Clear Cell Renal Cell Carcinoma | Stenzel PJ, Schindeldecker M, Teagscherer KE, Foersch S, Herpel E, Hohenfellner M, Hatiboglu G, Alt J, Thomas C, Haferkamp A, Roth W, Macher-Goeppinger S | 2020 | Translational Oncology | Oncology, Immuno-oncology | Classifier, Cytonuclear, TMA | HALO |
Linking epigenetic signature and metabolic phenotype in IDH mutant and IDH wildtype diffuse glioma | Buran Y, Filipski K, Bernatz S, Baumgarten P, Roller B, Zinke J, Zeiner PS, Ilina E, Senft C, Ronellenfitsch MW, Plate KH, Bähr O, Hattingen E, Steinbach JP, Mittelbron M, Harter PN | 2020 | Neuropathology and Applied Neurobiology | Neuroscience | Multiplex IHC, TMA | HALO |
O 6-Methylguanine DNA Methyltransferase and Glucose Transporter 2 in Foregut and Hindgut Gastrointestinal Neuroendocrine Neoplasms | Watanbe H, Yamazaki Y, Fujishima F, Izxumi K, Imamura M, Hijioka S, Toriyama K, Yatabe Y, Kudo A, Motoi F, Unno M, Sasano H | 2020 | BMC Cancer | Oncology | Cytonuclear | HALO |
SLFN11 informs on standard of care and novel treatments in a wide range of cancer models | Winkler C, Armenia J, Jones GN, Tobalina L, Sale MJ, Petreus T, Baird T, Serra V, Wang AT, Lau A, Garnett MJ, Jaaks P, Coker EA, Pierce AJ, O'Connor MJ, Leo E | 2020 | British Journal of Cancer | Oncology | Classifier, Cytonuclear | HALO |
Lung Expression of Human ACE2 Sensitizes the Mouse to SARS-CoV-2 Infection | Han K, Blair RV, Iwanaga N, Liu F, Russell-Lodrigue KE, Qin Z, Midkiff CC, Golden NA, Doyle-Meyers LA, Kabir ME, Chandler KE, Cutrera KL, Ren M, Monjure CJ, Lehmicke G, Fischer T, Beddingfield B, Wanek AG, Birnbaum A, Maness NJ, Roy CJ, Datta PK, Rappaport J, Kolls JK, Qin X | 2020 | American Journal of Respiratory Cell and Molecular Biology | Infectious Disease | HALO AI | |
Human ileal organoid model recapitulates clinical incidence of diarrhea associated with small molecule drugs | Belair DG, Visconti RJ, Hong M, Marella M, Peters MF, Scott CW, Kolaja KL | 2020 | Toxicology in Vitro | Toxicology | Highplex FL | HALO |
Multiomic analysis and immunoprofiling reveal distinct subtypes of human angiosarcoma | Chan JY, Lim JQ, Yeong J, Ravi V, Guan P, Boot A, Tay TKY, Selvarajan S, Nasir NDM, Loh JH, Ong CK, Huang D, Tan J, Li Z, Ng CC-Y, Tan TT, Masuzawa M, Sung KW-K, Farid M, Quek RHH, Tan NC, Teo MCC, Rozen SG, Tan P, Fotreal A, The BT, Soo KC | 2020 | The Journal of Clinical Investigation | Immuno-oncology | Highplex FL | HALO |
Tumoral PD-1hiCD8+ 1 T cells are partially exhausted and 2 predict favorable outcome in triple-negative breast cancer | Guo L, Cao C, Goswami S, Huang X, Ma L, Guo Y, Yang B, Li T, Chi Y, Zhang X, Wu J | 2020 | Clinical Science | Immuno-oncology | Highplex FL | HALO |
CXCR4+ cells are increased in lung tissue of patients with idiopathic pulmonary fibrosis | Jaffar J, Griffiths K, Oveissi S, Duan M, Foley M, Glaspole I, Symons K, Organ L, Westfall G | 2020 | Respiratory Research | Fibrosis | Highplex FL | HALO |
Rova-T enhances the anti-tumor activity of anti-PD1 in a murine model of small cell lung cancer with endogenous Dll3 expression | Vitorino P, Chuang C-H, Iannello Z, Zhao X, Anderson W, Ferrando R, Zhang Z, Madhavan S, Karsunky H, Saunders LR | 2020 | Translational Oncology | Immuno-oncology | Highplex FL | HALO |
Safety, immunogenicity, and clinical efficacy of durvalumab in combination with folate receptor alpha vaccine TPIV200 in patients with advanced ovarian cancer: a phase II trial | Zamarin D, Walderich S, Holland A, Zhou Q, Iasonos AE, Torrisi JM, Merghoub T, Chesebrough LF, Mcdonnell AS, Gallagher JM, Li Y, Hollmann TJ, Grisham RN, Erskine CL, Block MS, Knutson KL, O'Cearbhaill RE, Aghajanian C, Konner JA | 2020 | Journal for ImmunoTherapy of Cancer | Immuno-oncology | Highplex FL | HALO |
Trajectory and Functional Analysis of PD-1high CD4+CD8+ T Cells in Hepatocellular Carcinoma by Single-Cell Cytometry and Transcriptome Sequencing | Zheng B, Wang D, Qiu X, Luo G, Wu T, Yang S, Li Z, Zhu Y, Wang S, Wu R, Sui C, Gu Z, Shen S, Jeong S, Wu Z, Gu J, Wang H, Chen L | 2020 | Advanced Science | Immuno-oncology | Highplex FL | HALO |
Pulmonary Mycobacterium tuberculosis control associates with CXCR3- and CCR6-expressing antigen-specific Th1 and Th17 cell recruitment | Shanmugasundaram U, Bucsan AN, Ganatra SR, Ibegbu C, Quezada M, Blair RV, Alvarez X, Velu V, Kaushal D, Rengarajan J | 2020 | JCI Insight | Infectious Disease | Highplex FL | HALO AI |
A first-in-human, phase 1, dose-escalation study of ABBV-176, an antibody-drug conjugate targeting the prolactin receptor, in patients with advanced solid tumors | Lemech C, Woodward N, Chan N, Mortimer J, Naumovski L, Nuthalapati S, Tong B, Jiang F, Ansell P, Ratajczak CK, Sachdev J | 2020 | Investigational New Drugs | Oncology | ISH/FISH | HALO |
Gene expression of prostaglandin EP4 receptor in three canine carcinomas | Musser ML, Viall AK, Phillips RL, Hostetter JM, Johannes CM | 2020 | BMC Veterinary Research | Oncology | ISH/FISH | HALO |
Cholecystokinin-1 receptor agonist induced pathological findings in the exocrine pancreas of non-human primates | Nyborg NCB, Kirk RK, de Boer AS, Andersen DW, Bugge A, Wulff BS, Thorup I, Clausen TR | 2020 | Toxicology & Applied Pharmacology | Metabolism | ISH/FISH | HALO |
NPY mediates the rapid feeding and glucose metabolism regulatory functions of AgRP neurons | Ruud LE, Pereira MMA, de Solis AJ, Fenselau H, Bruning JC | 2020 | Nature Communications | Metabolism | ISH/FISH | HALO |
Age-determined expression of priming protease TMPRSS2 and localization of SARS-CoV-2 infection in the lung epithelium | Schuler BA, Habermann AC, Plosa EJ, Taylor CJ, Jetter C, Kapp ME, Benjamin JT, Gullerman P, Nichols DS, Braunstein LZ, Hackett A, Koval M, Guttentag SH, Blackwell TS, Webber SA, Banovich NE, Kropski JA, Sucre JMS | 2020 | The Journal of Clincial Invesitgation | Infectious Disease | ISH/FISH | HALO |
STAT3 inhibition with galiellalactone efectively targets the prostate cancer stem?like cell population | Canesin G, Maggio V, Palominos M, Stiehm A, Contreras HR, Castellon EA, Morote J, Paciucci R, Maitland NJ, Bjartell A, Hellsten R | 2020 | Scientific Reports | Oncology | Membrane | HALO |
Genetic alterations and expression characteristics of ARID1A impact tumor immune contexture and survival in early-onset gastric cancer | Zou J, Qin W, Wang L, Wang Y, Shen J, Xiong W, Yu S, Song S, Ajani JA, Lin S-Y, Mills GB, Yuan X, Chen J, Peng G | 2020 | American Journal of Cancer Research | Immuno-oncology | Spatial Analysis, Highplex FL | HALO |
Computational image analysis of T-cell infiltrates in resectable gastric cancer: association with survival and molecular subtypes | Challoner BR, von Loga K, Woolston A, Griffiths B, Sivamanoharan N, Semiannikova M, Newey A, Barber LJ, Mansfield D, Hewitt LC, Saito Y, Davarzani N, Starling N, Melcher A, Grabsch HI, Gerlinger M | 2020 | JNCI: Journal of the National Cancer Institute | Immuno-oncology | Multiplex IHC | HALO |
Temporal and Spatial Heterogeneity of Host Response to SARS-CoV-2 Pulmonary Infection | Desai N, Neyaz A, Szabolcs A, Shih AR, Chen JH, Thapar V, Nieman LT, Solovyov A, Mehta A, Lieb DJ, Kulkarni AS, Jaicks C, Pinto CJ, Juric D, Chebib I, Colvin RB, Kim AY, Monroe R, Warren SE, Danaher P, Reeves JW, Gong J, Rueckert EH, Greenbaum BD, Hacohen N, Lagana SM, Rivera MN, Sholl LM, Stone JR, Ting DT, Deshpande V | 2020 | medRxiv | Infectious Disease | Multiplex IHC | HALO |
An Antibody Targeting ICOS Increases Intratumoral Cytotoxic to Regulatory T-cell Ratio and Induces Tumor Regression | Sainson RCA, Thotakura AK, Kosmac M, Borhis G, Parveen N, Kimber R, Carvalho J, Henderson SJ, Pryke KL, Okell T, O'Leary S, Ball S, Van Krinks C, Gamand L, Taggart E, Pring EJ, Ali H, Craig H, Wong VWY, Liang Q, Rowlands RJ, Lecointre M, Campbell J, Kirby I, Melvin D, Germaschewski V, Oelmann E, Quaratino S, McCourt M | 2020 | Cancer Immunology Research | Immuno-oncology | Multiplex IHC | HALO |
Immunogradient Indicators for Antitumor Response Assessment by Automated Tumor-Stroma Interface Zone Detection | Rasmusson A, Zilenaite D, Nestarenkaite A, Augulis R, Laurinaviciene A, Ostapenko V, Poskus T, Laurinavicius A | 2020 | The American Journal of Pathology | Multiplex IHC | HALO AI | |
Neoadjuvant immunotherapy leads to pathological responses in MMR-proficient and MMR-deficient early-stage colon cancers | Chalabi M, Fanchi LF, Dijkstra KK, Van den Berg JG, Aalbers AG, Sikorska K, Lopez-Yurda M, Grootscholten C, Beets GL, Snaebjornsson P, Maas M, Mertz J, Veninga V, Bounova G, Broeks A, Beets-Tan RG, de Wijkerslooth TR, van Lent AU, Marsman HA, Nuijten E, Kok NF, Kuiper M, Verbeek WH, Kok M, Van Leerdam ME, Schumacher TN, Voest EE, Haanen JB | 2020 | Nature Medicine | Immuno-oncology | Multiplex IHC, Serial Section | HALO |
MCL1 inhibition is effective against a subset of small-cell lung cancer with high MCL1 and low BCL-XL expression | Yasuda Y, Ozasa H, Kim YH, Yamazoe M, Ajimizu H, Funazo TY, Nomizo T, Tsuji T, Yoshida H, Sakamori Y, Najajima N, Menju T, Yoshizawa A, Date H, Hirai T | 2020 | Cell Death & Disease | Oncology, Immuno-oncology | Cytonuclear | HALO |
Inhibition of myostatin prevents microgravity-induced loss of skeletal muscle mass and strength | Smith RC, Cramer MS, Mitchell PJ, Lucchesi J, Ortega AM, Livingston EW, Ballard D, Zhang L, Hanson J, Barton K, Berens S, Credille KM, Bateman TA, Ferguson VL, Ma YL, Stodieck LS | 2020 | PLOS One | Myology | Muscle Fiber | HALO |
Photoacoustic imaging biomarkers for monitoring biophysical changes during nanobubble-mediated radiation treatment | Hysi E, Fadhel MN, Wang Y, Sebastian JA, Giles A, Czarnota GJ, Exner AA, Kolios MC | 2020 | Photoacoustics | Other | Classifier, Area Quantification, Object Colocalization | HALO |
Single-cell analysis of germinal-center B cells informs on lymphoma cell of origin and outcome | Holmes AB, Corinaldesi C, Shen Q, Kumar R, Compagno N, Wang Z, Nitzan M, Grunstein E, Pasqualucci L, Dalla-Favera R, Basso K | 2020 | Journal of Experimental Medicine | Oncology | Registration | HALO |
Artificial intelligence as the next step towards precision pathology | Acs B, Rantalainen M, Hartman J | 2020 | Journal of Internal Medicine | Review | HALO | |
Ngly1?/? rats develop neurodegenerative phenotypes and pathological abnormalities in their peripheral and central nervous systems | Asahina M, Fujinawa R, Nakamura S, Yokoyama K, Tozawa R, Suzuki T | 2020 | Human Molecular Genetics | HALO | ||
Consumptive coagulopathy of severe yellow fever occurs independently of hepatocellular tropism and massive hepatic injury | Baileya AL, Kanga L-I, Zanellab LGFdABD, Silveirab CGT, Hod Y-H, Foquete L, Biale G, McCunef BT, Duarte-Netog AN, Thomash A, Rauéh H-P, Byrnesa K, Kallasd EG, Slifkah MK, Diamond MS | 2020 | Proceedings of the National Academy of Sciences | Infectious Disease | HALO | |
?-Synuclein modulates tau spreading in mouse brains | Bassil F, Meymand ES, Brown HJ, Xu H, Cox TO, Pattabhiraman S, Maghames CM, Wu Q, Zhang B, Trojanowski JQ, Lee VM-Y | 2020 | Journal of Experimental Medicine | Neuroscience | HALO | |
Ad26 vaccine protects against SARS-CoV-2 severe clinical disease in hamsters | Tostanoski LH, Wegmann F, Martinot AJ, Loos C, McMahan K, Mercado NB, Yu J, Chan CN, Bondoc S, Starke CE, Nekorchuk M, Busman-Sahay K, Piedra-Mora C, Wrijil LM, Ducat S, Custers J, Atyeo C, Fischinger S, Burke JS, Feldman J, Hauser BM, Caradonna TM, Bondzie EA, Dagotto G, Gebre MS, Jacob-Dolan C, Lin Z, Mahrokhian SH, Nampanya F, Nityanandam R, Pessaint L, Porto M, ALi V, Benetiene D, Tevi K, Andersen H, Lewis MG, Schmidt AG, Lauffenburger DA, Alter G, Estes JD, Schuitemaker H, Zahn R, Barouch DH | 2020 | Nature Medicine | Infectious Disease | Area Quantification, Multiplex IHC | HALO |
Prognostic relevance of programmed cell death protein 1/programmed death-ligand 1 pathway in thymic malignancies with combined immunohistochemical and biomolecular approach | Berardi R, Goteri G, Brunelli A, Pagliaretta S, Paolucci V, Caramanti M, Rinaldi S, Refai M, Pompili C, Morgese F, Torniai, Marcantognini, Ricci G, Mazzanti P, Onofri A, Bianchi F, Sabbatini A, Cascinu S | 2020 | Expert Opinion on Therapeutic Targets | Oncology | HALO | |
Liraglutide treatment improves endothelial function in the Ldlr?/? mouse model of atherosclerosis and affects genes involved in vascular remodelling and inflammation | Bjørnholm KD, Skovsted GF, Mitgaard-Thomsen A, Rakipovski G, Tveden-Nyborg P, Lykkesfeldt J, Povlsen GK | 2020 | Basic & Clinical Pharmacology & Toxicology | Immunology, Toxicology | HALO | |
Microglial-associated responses to comorbid amyloid pathology and hyperhomocysteinemia in an aged knock-in mouse model of Alzheimerís disease | Braun DJ, Dimayuga E, Morganti JM, Van Eldik LJ | 2020 | Journal of Neuroinflammation | Neuroscience | HALO | |
Glucagon Receptor Inhibition Reduces Hyperammonemia and Lethality in Male Mice with Urea Cycle Disorder | Cavino K, Sung B, Su Q, Na E, Kim J, Cheng X, Gromada J, Okamoto H | 2020 | Endocrinology | Metabolism | HALO | |
Immune parameters associated with survival in metaplastic breast cancer | Chao X, Liu L, Sun P, Yang X, Li M, Luo R, Huang Y, He J, Yun J | 2020 | Breast Cancer Research | Immuno-oncology | HALO | |
Alterations in Intestinal Innate Mucosal Immunity of Weaned Pigs During Porcine Epidemic Diarrhea Virus Infection | Chen Y-M, Helm ET, Gabler N, Hostetter JM, Burrough ER | 2020 | Veterinary Pathology | Infectious Disease | HALO | |
Expression of the Autoantigen Topoisomerase-1 is Enriched in the Lung Tissues of Patients With Autoimmune Interstitial Lung Disease: A Case Control Study | Cottrell TR, Askin F, Halushka MK, Casciola-Rosen L, McMahan ZH | 2020 | ACR Open Reumatology | Immunology | HALO | |
Growth Factor Receptor Expression in Oropharyngeal Squamous Cell Cancer: Her14 and c-Met in Conjunction with the Clinical Features and Human Papillomavirus (p16) Status | Deuss E, Gößwein D, Gül D, Zimmer S, Foersch S, Eger CS, Limburg I, Stauber RH, Künzel J | 2020 | Cancers | Oncology | HALO | |
Formoterol, a ?2-adrenoreceptor agonist, induces mitochondrial biogenesis and promotes cognitive recovery after traumatic brain injury | Vekaria HJ, Hubbard WB, Scholpa NE, Spry ML, Gooch JL, Prince SJ, Schnellmann Sullivan PG | 2020 | Neurobiology of Disease | Neuroscience | Area Quantification | HALO |
Deep Brain Stimulation of the Medial Septal Nucleus Induces Expression of a Virally Delivered Reporter Gene in Dentate Gyrus | Fomenko A, Lee DJ, McKinnon C, Lee EJ, de Snoo ML, Gondard E, Neudorfer C, Hamani C, Lozano AM, Kalia LV, Kalia SK | 2020 | Frontiers of Neuroscience | Neuroscience | HALO | |
The membrane protein sortilin can be targeted to inhibit pancreatic cancer cell invasion | Gao F, Griffin N, Faulkner S, Li X, King SJ, Jobling P, Denham JW, Jiang CC, Hondermarck H | 2020 | The American Journal of Pathology | Oncology | HALO | |
Neoadjuvant PD-L1 plus CTLA-4 blockade in patients with cisplatin-ineligible operable high-risk urothelial carcinoma | Gao J, Navai N, Alhalabi O, Siefker-Radtke A, Campbell MT, Tidwell RS, Guo CC, Kamat AM, Matin SF, Araujo CJ, Shah AY, Msaouel P, Corn P, Wang J, Papadopoulos JN, Yadav SS, Blando JM, Duan F, Basu S, Liu W, Shen Y, Macaluso MD, Wang Y, Chen J, Zhang J, Futreal A, Dinney C, Allison JP, Goswami S, Sharma P | 2020 | Nature Medicine | Toxicology | HALO | |
Intratumoral heterogeneity of the tumor cells based on in situ cortisol excess in cortisol-producing adenomas; An association among morphometry, genotype and cellular senescence | Gao X, Yamazaki Y, Tezuka Y, Pieroni J, Ishii K, Atsumi N, Ono Y, Omata K, Morimoto R, Nakamura Y, Satoh F, Sasano H | 2020 | The Journal of Steroid Biochemistry and Molecular Biology | Oncology | HALO | |
Nicotinic Receptor Subunit Distribution in Auditory Cortex: Impact of Aging on Receptor Number and Function | Ghimire M, Cai R, Ling L, Hackett TA, Caspary DM | 2020 | Journal of Neuroscience | Neuroscience | HALO | |
Acute brain inflammation, white matter oxidative stress, and myelin deficiency in a model of neonatal intraventricular hemorrhage | Goulding DS, Vogel RC, Gensel JC, Morganti JM, Stromberg AJ, Miller BA | 2020 | Journal of Neuroscience | Immunology, Neuroscience | HALO | |
Neonatal hydrocephalus leads to white matter neuroinflammation and injury in the corpus callosum of Ccdc39 hydrocephalic mice | Goulding DS, Vogel RC, Pandya CD, Shula C, Gensel JC, Mangano FT, Goto J, Miller BA | 2020 | Journal of Neurosurgery | Immunology, Neuroscience | HALO | |
Quantification of Viral and Host Biomarkers in the Liver of Rhesus Macaques: a Longitudinal Study of Zaire Ebolavirus strain Kikwit (EBOV/Kik) | Greenberg AR, Huber BR, Liu DX, Logue JP, Hischak AMW, Hart RJ, Abbott M, Isic N, Hisada YM, Mackman N, Bennet RS, Hensley LE, Connor JH, Crossland NA | 2020 | The American Journal of Pathology | HALO | ||
Clinicopathological significance of nerves in esophageal cancer | Griffin N, Rowe CW, Gao F, Jobling P, Wills V, Walker MM, Faulkner S, Hondermarck H | 2020 | The American Journal of Pathology | Oncology | HALO | |
The human IL-15 superagonist N-803 promotes migration of virus-specific CD8+ T and NK cells to B cell follicles but does not reverse latency in ART-suppressed, SHIV-infected macaques | Webb GM, Molden J, Bushman-Sahay K, Abdulhaqq S, Wu HL, Weber WC, Bateman KB, Reed JS, Northrup M, Maier N,Tanaka S, Gao L, Davey B, Carpenter BL, Axthelm MK, Stanton JJ, Smedley J, Greene JM, Safrit JT, Estes JD, Skinner PJ, Sacha JB | 2020 | PLOS Pathogens | Infectious Disease | Cytonuclear, ISH/FISH | HALO |
Neonatal therapy with PF543, a sphingosine kinase 1 inhibitor, ameliorates hyperoxia-indused airway remodeling in a murine model of bronchopulmonary dysplasia | Ha AW, Sudhadevi T, Ebenezeer DL, Fu P, Berdyshev EV, Ackerman SJ, Natarajan V, Harijith A | 2020 | American Journal of Physiology | Other | HALO | |
Investigating Radiotherapy Response in a Novel Syngeneic Model of Prostate Cancer | Haughey CM, Mukherjee D, Steele RE, Popple A, Dura-Perez L, Pickard A, Patel M, Jain S, Mullan PB, Williams R, Oliveira P, Buckley NE, Honeychurch J, McDade SS, Illidge T, Mills IG, Eddie SL | 2020 | Cancers | Oncology | HALO | |
Intratumoral interleukin-12 mRNA therapy promotes TH1 transformation of the tumor microenvironment | Hewitt SL, Bailey D, Zielinski J, Apte A, Musenge F, Karp R, Burke S, Garcon F, Mishra A, Gurumurthy S, Watkins A, Arnold K, Moynihan J, Clancy-Thompson E, Mulgrew K, Adjei G, Deschler K, Potz D, Moody G, Leinster DA, Novick S, Sulikowski M, Bagnall CJ, Martin P, Lapointe J-M, Si H, Morehouse CA, Sedic M, Wilkinson RW, Herbst R, Frederick JP, Luheshi N | 2020 | Clinical Cancer Research | Immuno-oncology | HALO | |
IFN-III is selectively produced by cDC1 and predicts good clinical outcome in breast cancer | Hubert M, Gobbini E, Couillault C, Manh T-PV, Doffin A-C, Berthet J, Rodriguez C, Ollion V, Kielbassa J, Sajous C, Treilleux I, Tredan O, Dubois B, Dalod M, Bendriss-Vermare N, Caux C, Valladeau-Guilemond J | 2020 | Immunology | HALO | ||
PNOCARC Neurons Promote Hyperphagia and Obesity upon High-Fat-Diet Feeding | Jais A, Paeger L, Sotelo-Hitschfeld T, Bremser S, Prinzensteiner M, Klemm P, Mykytiuk V, Widdershooven PJM, Vesting AJ, Grzelka K, Minere M, Cremer AL, Xu J, Korotkova T, Lowell BB, Zeilhofer HU, Backes H, Fenselau H, Wunderlich FT, Kloppenburg P, Bruning JC | 2020 | Neuron | Neuroscience | HALO | |
Tutorial: guidance for quantitative confocal miscroscopy | Jonkman J, Brown CM, Wright GD, Anderesion KI, North AJ | 2020 | Nature Protocols | HALO | ||
Omental macrophages secrete chemokine ligands that promote ovarian cancer colonization of the omentum via CCR1 | Krishnan V, Tallapragada S, Schaar B, Kamat K, Chanana AM, Zhang Y, Patel S, Parkash V, Rinker-Schaeffer C, Folkins AK, Rankin EB, Dorigo O | 2020 | Communications Biology | Oncology | HALO | |
A drug-induced hypotensive challenge to verify catheter-based radiofrequency renal denervation in an obese hypertensive swine model | Lauder L, Moon LB, Pipenhagen CA, Ewen S, Fish JM, Virmani R, Jensen JA, Böhm M, Mahfoud F | 2020 | Clinical Research in Cardiology | Myology | HALO | |
The identification and functional analysis of CD8+PD-1+CD161+ T cells in hepatocellular carcinoma | Li Z, Zheng B, Qiu X, Wu R, Wu T, Yang S, Zhu Y, Wu X, Wang S, Gu Z, Shen S, Wu M, Wang H, Chen L | 2020 | Percision Oncology | Immuno-oncology | HALO | |
The diagnostic and prognostic value of UBE2T in intrahepatic cholangiocarcinoma | Yu H, Wang H, Dong W, Cao Z-Y, Li R, Yang C, Cong W-M, Dong H, Jin G-Z | 2020 | Peer J | Oncology | Cytonuclear | HALO |
Degradation of the Tumor Suppressor PDCD4 Is Impaired by the Suppression of p62/SQSTM1 and Autophagy | Manirujjaman M, Ozaki I, Murata Y, Guo J, Xia J, Nishioka K, Perveen R, Takashashi H, Anzai K, Matsuhashi S | 2020 | Cells | Oncology | HALO | |
Robust and persistent reactivation of SIV and HIV by N-803 and depletion of CD8+ cells | McBrien JB, Mavigner M, Li LF, Smith SA, White E, Tharp GK, Walum H, Busman-Suhay K, Aguilera-Sandoval CR, Thayer WO, Spagnuolo RA, Kovarova M, Wahl A, Cervasi B, Margolis DM, Vanderford TH, Carnathan DG, Paiardini M, Lifson JD, Lee JH, Safrit JT, Bosinger SE, Estes JD, Derdeyn CA, Garcia JV, Kulpa DA, Chahroudi A, Silvestri G | 2020 | Nature | HALO | ||
Early-onset impairment of the ubiquitin-proteasome system in dopaminergic neurons caused by ?-synucleinn | McKinnon C, De Snoo ML, Gondard E, Neudorfer C, Chau H, Ngana SG, O'Hara DM, Brotchie JM , Koprich JB, Lozano AM, Kalia LV, Kalia SK | 2020 | Acta Neuropathologica Communications | Neuroscience | HALO | |
A Dedicated Evolutionarily Conserved Molecular Network Licenses Differentiated Cells to Return to the Cell Cycle | Miao Z-F, Lewis MA, Cho CJ, Adkins-Threats M, Park D, Brown JW, Sun J-X, Burclaff JR, Kennedy S, Lu J, Mahar M, Vietor I, Huber LA, Davidson NO, Cavalli V, Rubin DC, Wang Z-N, Mills JC | 2020 | Developmental Cell | HALO | ||
The Unfolded Protein Response Mediator PERK Governs Myeloid Cell-Driven Immunosuppression in Tumors through Inhibition of STING Signaling | Mohamed E, Sierra RA, Trillo-Tinoco J, Cao Y, Innamarato P, Payne KK, Pulido M, Mandula J, Zhang S, Thevenot P, Biswas S, Abdalla SK, Costich TL, Hanggi K, Anadon CM, Flores ER, Haura EB, Mehrotra, Pilon-Thomas S, Ruffel B, Munn DH, Cubillos-Ruiz JR, Conejo-Garcia JR, Rodriguez PC | 2020 | Immunity | Immuno-oncology | HALO | |
CD137 agonist-based combination immunotherapy enhances activated, effector memory T cells and prolongs survival in pancreatic adenocarcinoma | Muth ST, Saung MT, Blair AB, Henderson MG, Thomass DL II, Xheng L | 2020 | Cancer Letters | Immuno-oncology | HALO | |
Immunohistochemical scoring of CD38 in the tumor microenvironment predicts responsiveness to anti-PD-1/PD-L1 immunotherapy in hepatocellular carcinoma | Ng HHM, Lee RY, Goh S, Tay ISY, Lim X, Lee B, Chew V, Li H, Tan B, Lim S, Lim JCT, Au B, Loh JJH, Saraf S, Connolly JE, Loh T, Leow WQ, Lee JJX, Toh HC, Malavasi F, Lee SY, Chow P, Newell EW, Choo SP, Tai D, Yeong J, Lim TKH | 2020 | Journal for ImmunoTherapy of Cancer | Immuno-oncology | HALO | |
Features of increased malignancy in eosinophilic clear cell renal cell carcinoma | Nilsson H, Lindgren D, Axelson H, Brueffer C, Saal LH, Lundgren J, Johansson ME | 2020 | Journal of Pathology | Immuno-oncology | HALO | |
Antitumor Activity of Eribulin After Fulvestrant Plus CDK4/6 Inhibitor in Breast Cancer Patient-derived Xenograft Models | Niwa Y, Asano M, Nakagawa T, France D, Semba T, Funahashi Y | 2020 | Anticancer Research | Oncology | HALO | |
A Fas-4-1BB fusion protein converts a death to a pro-survival signal and enhances T cell therapy | Oda SK, Andereson KG, Ravikumar P, Bonson P, Garcia NM, Jenkins CM, Zhuang S, Daman A, Chiu EY, Bates BM, Greenberg PD | 2020 | Journal of Experimental Medicine | Immuno-oncology | HALO | |
The Arp2/3 complex is crucial for colonisation of the mouse skin by melanoblasts | Papalazarou V, Swaminathan K, Jaber-Hijaz Fi, Spence H, Lahmann I, Nixon C, Salmeron-Sanchez M, Arnold H-H, Rottner K, Machesky LM | 2020 | Development | Review | HALO | |
Incomplete Freunds adjuvant reduces arginase and enhances Th1 dominance, TLR signaling and CD40 ligand expression in the vaccine site microenvironment | Pollack KE, Meneveau MO, Melssen MM, Lynch KT, Koeppel AF, Young SJ, Turner S, Kumar P, Sol-Church K, Mauldin IS, Slingfluff CL | 2020 | Journal for ImmunoTherapy of Cancer | Immuno-oncology | HALO | |
Senescence, Necrosis, and Apoptosis Govern Circulating Cell-free DNA Release Kinetics | Rostami A, Lambie M, Yu CW, Stambolic V, Waldron JN, Bratman SV | 2020 | Cell Reports | Toxicology | HALO | |
Discoidin Domain Receptor 1 (DDR1) is Necessary for Tissue Homeostasis in Pancreatic Injury and Pathogenesis of Pancreatic Ductal Adenocarcinoman | Ruggeri JM, Franco-Barraza J, Sohail A, Zhang Y, Long D, di Magliano MP, Cukierman E, Fridman R, Crawford HC | 2020 | The American Journal of Pathology | Oncology, Immunology | HALO | |
Natural killer cells in the human lung tumor microenvironment display immune inhibitory functions | Russick J, Joubert P-E, Gillard-Bocquet M, Torset C, Meylan M, Petitprez F, Dragon-Durey M-A, Marmier S, Varthaman A, Josseaume N, Germain C, Jérémy Goc J, Dieu-Nosjean M-C, Validire P, Fournel L, Zitvogel L, Bindea G, Lupo A, Damotte D, Alifano M, Cremer I | 2020 | Journal for ImmunoTherapy of Cancer | Immuno-oncology | HALO | |
A potent peptide-steroid conjugate accumulates in cartilage and reverses arthritis without evidence of systemic corticosteroid exposure | Sanger MLC, Girard EJ, Hopping G, Yin C, Pakiam F, Brusniak M-Y, Nguyen E, Ruff R, Gewe MM, Byrnes-Blake K, Nairn NW, Miller DM, Mehlin C, Strand AD, Mhyre AJ, Correnti CE, Strong RK, Simon JA, Olson JM | 2020 | Science Translational Medicine | Immunology | HALO | |
Intratumoral Combinatorial Administration of CD1c (BDCA-1) + Myeloid Dendritic Cells Plus Ipilimumab and Avelumab in Combination with Intravenous Low-Dose Nivolumab in Patients with Advanced Solid Tumors: A Phase IB Clinical Trial | Schwarze JK, Awada G, Cras L, Tijtgat J, Forsyth R, Dufait I, Tuyaerts S, Riet VI, Neyns B | 2020 | Vaccines | Immuno-oncology | HALO | |
IL6/STAT3 Signaling Hijacks Estrogen Receptor ? Enhancers to Drive Breast Cancer Metastasis | Siersbæk R, Scabia V, Nagarajan S, Chernukhin I, Papachristou EK, Broome R, Johnston SJ, Joosten SEP, Green AR, Kumar S, Jones J, Omarjee S, Alvarez-Fernandez R, Glont S, Aitken SJ, Kishore K, Cheeseman D, Rakha EA, D'Santos C, Zwart W, Ruseel A, Brisken C, Carroll JS | 2020 | Cancer Cell | Oncology | HALO | |
GSTO1?1 is an upstream suppressor of M2 macrophage skewing and HIF?1??induced eosinophilic airway inflammation/a> | Sokulsky LA, Goggins B, Sherwin S, Eyeers F, Kaiko GE, Board PG, Keely S, Yang M, Foster PS | 2020 | Clinical & Experimental Allergy | Immunology | HALO | |
Neoantigen responses, immune correlates, and favorable outcomes after ipilimumab treatment of patients with prostate cancer | Subudhi SK, Vence L, Zhao H, Blando J, Yadav SS, Xiong Q, Reuben A, Aparicio A, Corn PG, Chapin BF, Pisters LL, Troncoso P, Tidwell RS, Thall P, Wu C-J, Zhang J, Logothetis CL, Futreal A, Allison JP, Sharma P | 2020 | Cancer | HALO | ||
Overview of multiplex immunohistochemistry/immunofluorescence techniques in the era of cancer immunotherapy | Tan WCCT, Nerurkar SN, Cai HY, Ng HHM, Wu D, Wee YTF, Lim JCT, Yeong J, Lim TKH | 2020 | Cancer Communications | Review | HALO | |
Association between CD8 and PD?L1 expression and outcomes after radical prostatectomy for localized prostate cancer | Vicier C, Ravi P, Kwak L, Werner L, Huang Y, Evan C, Loda M, Hamid AA, Sweeney CJ | 2020 | The Prostate | Immuno-oncology | HALO | |
Insoluble Tau From Human FTDP-17 Cases Exhibit Unique Transmission Properties In Vivo | Weitzman SA, Narasimhan S, He Z, Changolkar L, McBride JD, Zhang B, Schellenberg GD, Trojanowski JQ, Lee VMY | 2020 | Journal of Neuropathology & Experimental Neurology | Neuroscience | HALO | |
Engineering functional microvessels in synthetic polyurethane random-pore scaffolds by harnessing perfusion flow | Wright MEE, Yu JK, Jain D, Maeda A, Yeh S-CA, DaCosta RS, Lin CP, Santerre JP | 2020 | Biomaterials | HALO | ||
Neuronal activity modulates alpha-synuclein aggregation and spreading in organotypic brain slice cultures and in vivo | Wu Q, Shaikh MA, Meymand ES, Zhang B, Luk KC, Trojanowski JO, Lee VM-Y | 2020 | Acta Neuropathologica | Neuroscience | HALO | |
*A living biobank of matched pairs of patient-derived xenografts and organoids for cancer pharmacology | Xu X, Wang S, Zhou J, Chen J, Huang Y, Kumari R, Mao B, Zheng M, Wang J, Tu X, An X, Chen X, Zhang L, Tian X, Wang H, Dong X, Bao Z, Guo S, Ouyang X, Shan L, Wang F, Yan X, Li Z, Zhang R, Zhang H, Meiler S, Vries R, Clevers H | 2020 | *Pre-Print | Oncology | HALO | |
Safety and clinical activity of PD-L1 blockade in patients with aggressive recurrent respiratory papillomatosis | Allen CT, Lee S, Norberg SM, Kovalovsky D, Ye H, Clavijo PE, Hu-Lieskovan S, Schlegel R, Schlom J, Strauss J, Gulley JL, Trepel J, Hinrichs CS | 2019 | Journal for ImmunoTherapy of Cancer | Oncology, Immuno-oncology | Cytonuclear | HALO |
Cutaneous pharmacologic cAMP induction induces melanization of the skin and improves recovery from ultraviolet injury in melanocortin 1 receptor?intact or heterozygous skin | Bautista R-M, Carter KM, Jarrett SG, Napier D, Wakamatsu K, Ito S, D'Orazio JA | 2019 | Pigment Cell & Melanoma Research | Dermatology | Area Quantification | HALO |
Islet amyloidosis in a child with type 1 diabetes | Beery ML, Jacobsen LM, Atkinson MA, Butler AE, Campbell-Thompson M | 2019 | Islets | Metabolism | Classifier | HALO |
Predicting breast cancer response to neoadjuvant chemotherapy based on tumor vascular features in needle biopsies | Brocato TA, Brown-Glaberman U, Wang Z, Selwyn RG, Wilson CM, Wyckoff EF, Lomo LC, Saline JL, Hooda-Nehra A, Pasqualini R, Arap W, Brinker CJ, Cristini V | 2019 | JCI Insight | Oncology | Classifier | HALO |
Magnetic Resonance Imaging as a Biomarker in Rodent Peripheral Nerve Injury Models Reveals an Age-Related Impairment of Nerve Regeneration | Giorgetti E, Obrecht M, Ronco M, Panesar M, Lambert C, Accart N, Doelemeyer A, Nash M, Bidinosti M, Beckmann N | 2019 | Scientific Reports | Neuroscience | Classifier | HALO |
Unmasking of oestrogen?dependent changes in left ventricular structure and function in aged female rats: a potential model for pre?heart failure with preserved ejection fraction | Bustamante M, Garate?Carrillo A, Ito BR, Garcia R, Carson N, Ceballos G, Ramirez?Sanchez I, Omens J, Villarreal F | 2019 | The Journal of Physiology | Myology | Area Quantification, Layer Thickness | HALO |
MEDI3039, a novel highly potent tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) receptor 2 agonist, causes regression of orthotopic tumors and inhibits outgrowth of metastatic triple-negative breast cancer | Greer YE, Gilbert SF, Gril B, Narwal R, Brooks DLP, Tice DA, Steeg PS, Lipkowitz | 2019 | Breast Cancer Research | Oncology | Classifier | HALO |
Glucose-Dependent Insulinotropic Polypeptide Receptor-Expressing Cells in the Hypothalamus Regulate Food Intake | Adriaenssens AE, Biggs EK, Darwish T, Tadross J, Sukthankar T, Girish M, Polex-Wolf J, Lam BY, Zvetkova I, Pan W, Chiarugi D, Yeo GSH, Blouet C, Gribble FM, Reimann F | 2019 | Cell Metabolism | Metabolism | ISH/FISH | HALO |
Intravital imaging reveals systemic ezrin inhibition impedes cancer cell migration and lymph node metastasis in breast cancer | Ghaffari A, Hoskin V, Turashvili G, Varma S, Mewburn J, Mullins G, Greer PA, Kiefer F, Day AG, Madarnas Y, SenGupta S, Elliott BE | 2019 | Breast Cancer Research | Oncology | Classifier, Cytonuclear | HALO |
Modulation of Microglia by Voluntary Exercise or CSF1R Inhibition Prevents Age-Related Loss of Functional Motor Units | Giorgetti E, Panesar M, Zhang Y, Joller S, Ronco M, Obrecht M, Lambert C, Accart N, Beckmann N, Doelemeyer A, Perrot L, Fruh I, Mueller M, Pierrel E, Summermatter S, Bidinosti M, Shimshek DR, Brachat S, Nash M | 2019 | Cell Reports | Neuroscience | Classifier, Cytonuclear | HALO |
LLRRK2 inhibition does not impart protection from ?-synuclein pathology and neuron death in non-transgenic mice | Henderson MX, Sengupta M, McGeary I, Zhang B, Olufemi MF, Brown H, Trojanowski JQ, Lee VMY | 2019 | Acta Neuropathologica Communications | Neuroscience | Area Quantification, Cytonuclear | HALO |
Tumor Characteristics Associated with Benefit from Pembrolizumab in Advanced Non-Small Cell Lung Cancer | Hu-Lieskovan S, Lisberg A, Zaretsky JM, Grogan TR, Rizvi H, Wells DK, Carroll J, Cummings A, Madrigal J, Jones B, Gukasyan J, Shintaku IP, Slamon D, Dubinett S, Goldman JW, Elashoff D, Hellmann MD, Ribas A, Garon EB | 2019 | Clinical Cancer Research | Immuno-oncology | Cytonuclear | HALO |
Empiric Methods to Account for Pre-analytical Variability in Digital Histopathology in Frontotemporal Lobar Degeneration | Giannini LAA, Xie SX, Peterson C, Zhou C, Lee EB, Wolk DA, Grossman M, Trojanowski JQ, McMillan CT, Irwin DJ | 2019 | Frontiers in Neuroscience | Neuroscience | Area Quantification, Registration, Figure Maker | HALO |
Alterations of the MEK/ERK, BMP, and Wnt/?-catenin pathways detected in the blood of individuals with lymphatic malformations | Kim T, Tafoya E, Chelliah MP, Lekwuttikarn R, Li J, Sarin KY, Teng J | 2019 | PLOS One | Other | Cytonuclear | HALO |
Detection and quantification of Parascaris P-glycoprotein drug transporter expression with a novel mRNA hybridization technique | Chelladurai JJ, Brewer MT | 2019 | Veterinary Parasitology | Infectious Disease | ISH/FISH | HALO |
IL-7-dependent compositional changes within the ?? T cell pool in lymph nodes during ageing lead to an unbalanced anti-tumour response | Chen H-C, Eling N, Martinez-Jimenez CP, O'Brien LM, Carbonaro V, Marioni JC, Odom DT, de la Roche M | 2019 | EMBO Reports | Oncology, Immuno-oncology | ISH/FISH | HALO |
Assessment of PD-L1 mRNA and protein expression in non-small cell lung cancer, head and neck squamous cell carcinoma and urothelial carcinoma tissue specimens using RNAScope and immunohistochemistry | Duncan DJ, Scott M, Scorer P, Barker C | 2019 | PLOS One | Oncology, Immuno-oncology | ISH/FISH | HALO |
Expression of cholecystokinin by neurons in mouse spinal dorsal horn | Guitierrez-Mecinas M, Bell AM, Shepherd F, Polgar E, Watanabe M, Furuta T, Todd AJ | 2019 | The Journal of Comparitive Neurology | Neuroscience | ISH/FISH | HALO |
Methacrylic Acid Copolymer Coating Enhances Constructive Remodeling of Polypropylene Mesh by Increasing the Vascular Response | Coindre VF, Carleton MM, Sefton MV | 2019 | Advanced Healthcare Materials | Biomaterials | Area Quantification | HALO |
Cognitive and Pathological Influences of Tau Pathology in Lewy Body Disorders | Coughlin DG, Xie SX, Liang M, Williams A, Peterson C, Weintraub D, McMillan CT, Wolk DA, Akhtar RS, Hurtig H, Coslett HB, Hamilton R, Siderowf A, Duda JE, Rascovsky K, Lee EB, Lee VM-Y, Grossman M, Trojanowski JQ, Irwin DJ | 2019 | Annals of Neurology | Neuroscience | Classifier, Area Quantification | HALO |
CCN3/Nephroblastoma Overexpressed Is a Functional Mediator of Prostate Cancer Bone Metastasis That Is Associated with Poor Patient Prognosis | Dankner M, Ouellet V, Communal L, Schmitt E, Perkins D, Annis MG, Barrès V, Caron C, Mes-Masson A-M, Saad F, Siegel PM | 2019 | The American Journal of Pathology | Oncology | Area Quantification | HALO |
Divergent patterns of TDP?43 and tau pathologies in primary progressive aphasia | Giannini LAA, Xie SX, McMillan CT, Liang M, Williams A, Jester C, Rascovsky K, Wolk DA, Ash S, Lee EB, Trojanowski JQ, Grossman M, Irwin DJ | 2019 | Annals of Neurology | Neuroscience | Area Quantification | HALO |
Characterization of novel conformation-selective ?-synuclein antibodies as potential immunotherapeutic agents for Parkinson's disease | Henderson MX, Covell DJ, Chung C-HY, Pitkin RM, Sandler RM, Decker SC, Riddle DM, Zhang B, Gathagan RJ, James MJ, Trojanowski JQ, Brunden KR, Lee VMY, Luk KC | 2019 | Neurobiology of Disease | Neuroscience | Area Quantification | HALO |
Alzheimerís disease tau is a prominent pathology in LRRK2 Parkinsonís disease | Henderson MX, Sengupta M, Trojanowski JQ, Lee VMY | 2019 | Acta Neuropathologica Communications | Neuroscience | Area Quantification | HALO |
Lenvatinib induces death of human hepatocellular carcinoma cellsharboring an activated FGF signaling pathway through inhibition ofFGFReMAPK cascades | Hoshi T, Miyano SW, Watanabe H, Sonobe RMK, Seki Y, Ohta E, Nomoto K, Matsui J, Funahashi Y | 2019 | Biochemical and Biophysical Research Communications | Oncology | Area Quantification | HALO |
Molecular and functional heterogeneity of cancer associated fibroblasts in high-grade serous ovarian cancer | Hussain A, Voisin V, Poon S, Dmytryshyn J ,Richman C, Meens J, Ho VW, Tang KH, Paterson J, Clarke B, Bernardini M, Bader G, Neel B, Ailles L | 2019 | bioRxiv | Oncology | Classifier, Area Quantification | HALO |
Alzheimer Disease Pathology-Associated Polymorphism in a Complex Variable Number of Tandem Repeat Region Within the MUC6 Gene, Near the AP2A2 Gene | Katsumata Y, Fardo DW, Bachstetter AD, Artiushin SC, Wang W-X, Wei A, Brzezinski LJ, Nelson BG, Huang Q, Abner EL, Anderson S, Patel I, Shaw BC, Price DA, Niedowicz DM, Wilcock DW, Jicha GA, Neltner JH, Van Eldik LJ, Estus S, Nelson PT | 2019 | Journal of Neuropathology & Experimental Neurology | Neuroscience | Area Quantification, Cytonuclear | HALO |
IRAK4 mediates colitis-induced tumorigenesis and chemoresistance in colorectal cancer | Li Q, Chen Y, Zhang D, Grossman J, Li L, Khurana N, Jiang H, Grierson PM, Herndon J, DeNardo DG, Challen GA, Liu J, Ruzinova MB, Fields RC, Lim K-H | 2019 | JCI Insight | Oncology, Immuno-oncology | Area Quantification | HALO |
Dysregulated expression but redundant function of the long non-coding RNA HOTAIR in diabetic kidney disease | Majumder S, Hadden MJ, Thieme K, Batchu SN, Niveditha D, Chowdhury S, Yerra VG, Advani SL, Bowskill BB, Liu Y, Vakili H, Alghamdi TA, White KE, Geldenhuys L, Siddiqi FS, Advani A | 2019 | Diabetologia | Metabolism | Area Quantification | HALO |
Targeted drug delivery via caveolae-associated protein PV1 improves lung fibrosis | Marchetti GM, Burwell TJ, Peterson NC, Cann JA, Hanna RN, Li Q, Ongstad EL, Boyd JT, Kennedy MA, Zhao W, Rickert KW, Grimsby JS, DallAcqua WF, Wu H, Tsui P, Borrok MJ, Gupta R | 2019 | Communications Biology | Fibrosis | Area Quantification | HALO |
Persistence of inflammatory phenotype in residual psoriatic plaques in patients on effective biologic therapy: Residual Psoriatic Plaques After Treatment | Mashiko S, Edelmayer RM, Bi Y, Olson LM, Wetter JB, Wang J, Maari C, Proulx ES-C, Kaimal V, Li X, Salte K, Garcet S, Kannan AK, Huang SM, Cao X, Liu Z, Krueger JG, Sarfati M, Bissonnette R, Smith KM | 2019 | Journal of Investigative Dermatology | Immunology, Dermatology | Area Quantification | HALO |
In Situ Temporospatial Characterization of the Glial Response to Prion Infection | Michael AV, Greenlee JJ, Harm TA, Moore SJ, Zhang M, Lind MS, Greenlee MHW, Smith JD | 2019 | Veterinary Pathology | Immunology, Neuroscience, Infectious Disease | Area Quantification | HALO |
Exposure to maternal obesity programs sex differences in pancreatic islets of the offspring in mice | Nicholas LM, Nagao M, Kusinski LC, Fernandez-Twinn DS, Eliasson L, Ozanne SE | 2019 | Diabetologia | Metabolism | Area Quantification | HALO |
Histological characterization of aldosterone-producing adrenocortical adenomas with different somatic mutations | Ono Y, Yamazaki Y, Omata K, Else T, Tomlins SA, Rhayem Y, Williams TA, Reincke M, Carling T, Monticone S, Mulatero P, Beuschlein F, Ito S, Satoh F, Rainey WE, Sasano H | 2019 | The Journal of Clinical Endocrinology & Metabolism | Oncology | Classifier, Area Quantification | HALO |
Epithelial to mesenchymal plasticity and differential response to therapies in pancreatic ductal adenocarcinoma | Porter RL, Magnus NKC, Thapar V, Morris R, Szabolcs A, Neyaz A, Kulkarni AS, Tai E, Chougule A, Hillis A, Golczer G, Guo H, Yamada T, Kurokawa T, Yashaswini C, Ligorio M, Vo KD, Nieman L, Liss AS, Deshpande V, Lawrence MS, Maheswaran S, Fernandez-Del Castillo C, Hong TS, Ryan DP, ODwyer PJ, Drebin JA, Ferrone CR, Haber DA, Ting DT | 2019 | Proceedings of the National Academy of Sciences | Oncology | Area Quantification | HALO |
Multiplexed Immunohistochemistry for Molecular and Immune Profiling in Lung CancerÄîJust About Ready for Prime-Time? | Hofman P, Badoual C, Henderson F, Berland L, Hamila M, Long-Mira E, Lassalle S, Roussel H, Hofman V, Tartour E, Ilié M | 2019 | Cancers | Oncology, Immuno-oncology, Review | Classifier, Multiplex IHC | HALO |
Quantification of histopathological findings using a novel image analysis platform | Horai Y, Mizukawa M, Nishina H, Nishikawa S, Ono Y, Takemoto K, Baba N | 2019 | Journal of Toxicologic Pathology | Toxicology | Classifier | HALO |
Ex vivo tissue slice culture system to measure drug-response rates of hepatic metastatic colorectal cancer | Martin SZ, Wagner DC, Hörner N, Horst D, Lang H, Tagscherer KE, Roth W | 2019 | BMC Cancer | Oncology | Classifier, Cytonuclear | HALO |
Neutrophil content predicts lymphocyte depletion and anti-PD1 treatment failure in NSCLC | Kargl J, Zhu X, Zhang H, Yang GHY, Friesen TJ, Shipley M, Maeda DY, Zebala JA, McKay-Fleisch J, Meredith G, Mashadi-Hossein A, Baik C, Pierce RH, Redman MW, Thompson JC, Albelda SM, Bolouri H, Houghton AM | 2019 | JCI Insight | Immuno-oncology | Classifier, Highplex FL | HALO |
Precision immunoprofiling by image analysis and artificial intelligence | Koelzer VH, Sirinukunwattana K, Rittscher J, Mertz KD | 2019 | Vichows Archiv | Review | Classifier, Multiplex IHC, Spatial Analysis | HALO |
Machine learning approaches for pathologic diagnosis | Komura D, Ishikawa S | 2019 | Vichows Archiv | Review | Classifier | HALO AI |
MYB-NFIB gene fusions identified in archival adenoid cystic carcinoma tissue employing NanoString analysis: an exploratory study | McIntyre JB, Ko JJ, Siever J, Chan AMY, Simpson RHW, Hao D, Lau HY | 2019 | Diagnostic Pathology | Oncology | Classifier, Highplex FL | HALO |
A Dual Blocker of Endothelin A/B Receptors Mitigates Hypertension but not Renal Dysfunction in a Rat Model of Chronic Kidney Disease and Sleep Apnea | Morales-Loredo H, Jones DT, Barrera A, Mendiola P, Garcia J, Pace CE, Murphy M, Kanagy NL, Gonzalez Bosc LV | 2019 | Renal Pathology | Metabolism | Classifier, Cytonuclear, Figure Maker | HALO |
Detection of Lung Cancer Lymph Node Metastases from Whole-Slide Histopathologic Images Using a Two-Step Deep Learning Approach | Pham HHN, Futakuchi M, Bychkov A, Furukawa T, Kuroda K, Fukuoka J | 2019 | The American Journal of Pathology | Oncology | Classifier | HALO AI |
Imaging Mass Spectrometry and Proteome Analysis of Marek's Disease Virus-Induced Tumors | Pauker VI, Bertzbach LD, Hohmann A, Kheimar A, Teifke JP, Mettenleiter TC, Karger A, Kaufe BB | 2019 | mSpere | Oncology | Cytonuclear | HALO |
TNF-? Contributes to Lymphoid Tissue Disorganization and Germinal Center B Cell Suppression during Intracellular Bacterial Infection | Popescu M, Cabrera-Martinez B, Winslow GM | 2019 | The Journal of Immunology | Immunology | Cytonuclear | HALO |
Characterization of psoriasiform dermatitis induced by systemic injection of interleukin?23 minicircles in mice | Leys L, Wang Y, Paulsboe S, Edelmayer R, Salte K, Wetter J, Namovic M, Phillips L, Dunstan R, Gauvin D, Donnelly-Roberts D, Su Z, Honore P, McGaraughty S | 2019 | The Journal of Dermatology | Dermatology | Area Quantification, Layer Thickness | HALO |
Automated Computational Detection, Quantitation, and Mapping of Mitosis in WholeÄëSlide Images for Clinically Actionable Surgical Pathology Decision Support | Puri M, Hoover S, Hewitt S, Wei B-R, Adissu H, Halsey C, Beck J, Bradley C, Cramer S, Durham A, Esplin D, Frank C, Lyle L, McGill L, Sanchez M, Schaffer P, Traslavina R, Buza E, Yang H, Lee M, Dwyer J, Simpson R | 2019 | Journal of Pathology Informatics | Oncology | Cytonuclear | HALO |
Lamin?B1 is a senescence?associated biomarker in clear?cell renal cell carcinoma | Radspieler M, Schindeldecker M, Stenzel P, Försc S, Tagscherer K, Herpel E, Hohenfellner M, Hatiboglu G, Roth W, Macher?Goeppinger S | 2019 | Oncology Letters | Oncology | Cytonuclear | HALO |
Upper tract urothelial carcinoma has a luminal-papillary T-cell depleted contexture and activated FGFR3 signaling | Robinson BD, Vlachostergios PJ, Bhinder B, Liu W, Li K, Moss TJ, Bareja R, Park K, Tavassoli P, Cyrta J, Tagawa ST, Nanus DM, Beltran H, Molina AM, Khani F, Miguel Mosquera J, Xylinas E, Shariat SF, Scherr DS, Rubin MA, Lerner SP, Matin SF, Elemento O, Faltas BM | 2019 | Nature Communications | Oncology, Immuno-oncology | Cytonuclear | HALO |
IL?36 receptor antagonistic antibodies inhibit inflammatory responses in preclinical models of psoriasiform dermatitis | Su Z, Paulsboe S, Wetter J, Salte K, Kannan A, Mathew S, Horowitz A, Gerstein C, Namovic M, Todorovi? V, Seagal J, Edelmayer RM, Viner M, Rinaldi L, Zhou L, Leys L, Huang S, Wang L, Sadhukhan R, Honore P, McGaraughty S, Scott VE | 2019 | Experimental Dermatology | Dermatology | Area Quantification, Cytonuclear | HALO |
Neurexin 3 transmembrane and soluble isoform expression and splicing haplotype are associated with neuron inflammasome and Alzheimer's disease | Hishimoto A, Pletnikova O, Lang DL, Troncoso JC, Egan JM, Liu Q-R | 2019 | Alzheimer's Research & Therapy | Neuroscience | ISH/FISH | HALO |
IL?1? cleavage by inflammatory caspases of the noncanonical inflammasome controls the senescence?associated secretory phenotype | Wiggins KA, Parry AJ, Cassidy LD, Humphry M, Webster SJ, Goodall JC, Narita M, Clarke MCH | 2019 | Aging Cell | Immunology | Cytonuclear | HALO |
The role of WNT10B in normal prostate gland development and prostate cancer | Madueke I, Hu W-Y, Hu D, Swanson SM, Griend DV, Abern M, Prins GS | 2019 | The Prostate | Oncology | Multiplex IHC, TMA | HALO |
Role of IL-15 Signaling in the Pathogenesis of Simian Immunodeficiency Virus Infection in Rhesus Macaques | Okoye AA, DeGottardi MQ, FukazawaY, Vaidya M, Abana CO, Konfe AL, Fachko DN, Duell DM, He Li H, Lum R, Gao L, Park BS, Skalsky RL, Lewis AD, Axthelm MK, Lifson JD, Wong SW, Picker LJ | 2019 | The Journal of Immunology | Infectious Disease | Cytonuclear, Figure Maker | HALO |
A Deep Learning Convolutional Neural Network Can Recognize Common Patterns of Injury in Gastric Pathology | Martin DR, Hanson JA, Gullapalli RR, Schultz FA, Sethi A, Clark DP | 2019 | Archives of Pathology and Laboratory Medicine | Gastroenterology | HALO AI | |
Advanced Prostate Cancer with ATM Loss: PARP and ATR Inhibitors | Neeb A, Herranz N, Arce-Gallego S, Miranda S, Lorenzo Buroni L, Wei Yuan W, Alejandro Athie A, Teresa Casals T, Juliet Carmichael J, Daniel Nava Rodrigues DN, Bora Gurel B, Pasquale Rescigno P, Jan Rekowski J, Jon Welti J, Ruth Riisnaes R, Veronica Gil V, Jian Ning J, Verena Wagner, Irene Casanova-Salas I, Cordoba S, Natalia Castro N, Maria Dolores Fenor de la Maza, George Seed, Khobe Chandran, Ana Ferreira A, Ines Figueiredo I, Claudia Bertan, Diletta Bianchini, Caterina Aversa, Alec Paschalis A, Macarena Gonzalez N, Rafael Morales-Barrera, Cristina Suarez C, Joan Carles J, Amanda Swain A, Adam Sharp A, Jesus Gil, Violeta Serra, Christopher Lord, Suzanne Carreira S, Joaquin Mateo, Johann S. de Bono JS | 2019 | European Urology | Oncology | HALO AI | |
Reduction of Global H3K27me3 Enhances HER2/ErbB2 Targeted Therapy | Hirukawa A, Singh S, Wang J, Rennhack JP, Swiatnicki M, Sanguin-Gendreau V, Zuo D, Daldoul K, Lavoie C, Park M, Andrechek ER, Westbrook TF, Harris LN, Varadan V, Smith HW, Muller WJ | 2019 | Cell Reports | Oncology | Highplex FL | HALO |
Macrophage-Derived CXCL9 and CXCL10 Are Required for Antitumor Immune Responses Following Immune Checkpoint Blockade | House IG, Savas P, Lai J, Chen AXY, Oliver AJ, Teo ZL, Todd KL, Henderson MA, Giuffrida L, Petley EV, Sek K, Mardiana S, Gide TN, Quek C, Scolyer RA, Long GV, Wilmott JS, Loi S, Darcy PK, Beavis PA | 2019 | Clinical Cancer Research | Immuno-oncology | Highplex FL | HALO |
A single dose of neoadjuvant PD-1 blockade predicts clinical outcomes in resectable melanoma | Huang AC, Orlowski RJ, Xu X, Mick R, George SM, Yan PK, Manne S, Kraya AA, Wubbenhorst B, Dorfman L, DAndrea K, Wenz BM, Liu S, Chilukuri L, Kozlov A, Carberry M, Giles L, Kier MW, Quagliarello F, McGettigan S, Kreider K, Annamalai L, Zhao Q, Mogg R, Xu W, Blumenschein WM, Yearley JH, Linette GP, Amaravadi RK, Schuchter LM, Herati RS, Bengsch B, Nathanson KL, Farwell MD, Karakousis GC, Wherry EJ, Mitchell TC | 2019 | Nature Medicine | Oncology, Immuno-oncology | Highplex FL | HALO |
CXCR3 enables recruitment and site-specific bystander activation of memory CD8+ T cells | Maurice NJ, McElrath MJ, Andersen-Nissen E, Frahm N, Prlic M | 2019 | Nature Communications | Immunology | Highplex FL | HALO |
Development of resistance to FAK inhibition in pancreatic cancer is linked to stromal depletion | Jiang H, Liu X, Knolhoff BL, Hegde S, Lee KB, Jiang H, Fields RC, Pachter JA, Lim K-H, DeNardo DG | 2019 | Gut | Oncology | Cytonuclear, ISH/FISH | HALO |
Single-Cell Quantification of mRNA Expression in The Human Brain | Jolly S, Lang V, Koelzer VH, Frigerio CS, Magno L, Salinas PC, Whiting P, Palomer E | 2019 | Scientific Reports | Neuroscience | ISH/FISH | HALO |
The Fat Mass and Obesity-Associated Protein (FTO) Regulates Locomotor Responses to Novelty via D2R Medium Spiny Neurons | Ruud J, Alber J, Tokarska A, Engström Ruu L, Nolte H, Biglari N, Lippert R, Lautenschlager Ä, Cie?lak PE, Szumiec ?, Hess ME, Brönneke HS, Krüger M, Nissbrandt H, Korotkova T, Silberberg G, Rodriguez Parkitna J, Brüning J | 2019 | Cell Reports | Neuroscience, Metabolism | ISH/FISH | HALO |
Quantitative digital pathology reveals association of cell-specific PNPLA3 transcription with NAFLD disease activity | Sandhu B, Perez Matos MC, Tran S, Zhong A, Csizmadia E, Kim M, Herman MA, Nasser I, Lai M, Jiang ZG | 2019 | JHEP Reports | Fibrosis | ISH/FISH | HALO |
Alpha-synuclein is a DNA binding protein that modulates DNA repair with implications for Lewy body disorders | Schaser AJ, Osterberg VR, Dent SE, Stackhouse TL, Wakeham CM, Boutros SW, Weston LJ, Owen N, Weissman TA, Luna E, Raber J, Luk KC, McCullough AK, Woltjer RL, Unni VK | 2019 | Scientific Reports | Neuroscience | ISH/FISH | HALO |
Small Molecule IL-36? Antagonist as a Novel Therapeutic Approach for Plaque Psoriasis | Todorovi? V, Su Z, Putman CB, Kakavas SJ, Salte KM, McDonald HA, Wetter JB, Paulsboe SE, Sun Q, Gerstein CE, Medina L, Sielaff B, Sadhukhan R, Stockmann H, Richardson PL, Qiu W, Argiriadi MA, Henry RF, Herold JM, Shotwell JB, McGaraughty SP, Honore P, Gopalakrishnan SM, Sun CC, Scott VE | 2019 | Scientific Reports | Immunology, Dermatology | ISH/FISH | HALO |
Changes in epidermal morphology associated with dandruff | Pople JE, Bhogal RK, Moore AE, Jenkins G | 2019 | International Journal of Cosmetic Science | Dermatology | Cytonuclear, Layer Thickness | HALO |
PD-L1 Expression and Clinical Outcomes to Cabozantinib, Everolimus, and Sunitinib in Patients with Metastatic Renal Cell Carcinoma: Analysis of the Randomized Clinical Trials METEOR and CABOSUN | Flaifel A, Xie W, Braun DA, Ficial M, Bakouny Z, Nassar AH, Jennings RB, Escudier B, George DJ, Motzer RJ, Morris MJ, Powles, Wang E, Huang Y, Freeman GJ, Choueiri TK, Signoretti S | 2019 | Clinical Cancer Research | Immuno-oncology | Multiplex IHC | HALO |
The KDM5A/RBP2 histone demethylase represses NOTCH signaling to sustain neuroendocrine differentiation and promote small cell lung cancer tumorigenesis | Oser MG, Sabet AH, Gao W, Chakraborty AA, Schinzel AC, Jennings RB, Fonseca R, Bonal DM, Booker MA, Flaifel A, Novak JS, Christensen VL, Zhang H, Herbert ZT, Tolstorukov MY, Buss EJ, Wong K-K, Bronson RT, Nguyen Q-D, Signoretti S, Kaelin Jr WG | 2019 | Genes & Development | Oncology | Multiplex IHC | HALO |
Physiologic serum 1,25 dihydroxyvitamin D is inversely associated with prostatic Ki67 staining in a diverse sample of radical prostatectomy patients | Rosenberg A, NetteY OS, Gogana P, Sheikh U, Virgilia M, Macias V, Kajdacsy-Balla A, R Sharifi R, Kittles RA, Murphy AB | 2019 | Cancer Causes & Control | Oncology | Multiplex IHC | HALO |
Nuclear Glycogenolysis Modulates Histone Acetylation in Human Non-Small Cell Lung Cancers | Sun RC, Dukhande VV, Zhou Z, Young LEA, Emanuelle S, Brainson CF, Gentry MS | 2019 | Cell Metabolism | Oncology | Multiplex IHC | HALO |
Inducing and exploiting vulnerabilities for the treatment of liver cancer | Wang C, Vegna S, Jin H, Benedict B, Lieftink C, Ramirez C, de Oliveira RL, Morris B, Gadiot J, Wang W, du Chatinier A, Wang L, Gao D, Evers B, Jin G, Xue Z, Schepers A, Jochems F, Sanchez AM, Mainardi S, te Riele H, Beijersbergen RL, Qin W, Akkari L, Bernards R | 2019 | Nature | Oncology | Multiplex IHC | HALO |
Neoadjuvant anti-PD-1 immunotherapy promotes a survival benefit with intratumoral and systemic immune responses in recurrent glioblastoma | Cloughesy TF, Mochizuki AY, Orpilla JR, Hugo W, Lee AH, Davidson TB, Wang AC, Ellingson BM, Rytlewski JA, Sanders CM, Kawaguchi ES, Du L, Li G, Yong WH, Gaffey SC, Cohen AL, Mellinghoff IK, Lee EQ, Reardon DA, OBrien BJ, Butowski NA, Nghiemphu PL, Clarke JL, Arrillaga-Romany IC, Colman H, Kaley TJ, de Groot JF, Liau LM, Wen PY, Prins RM | 2019 | Nature Medicine | Oncology, Immuno-oncology | Spatial Analysis, Highplex FL | HALO |
PAK4 inhibition improves PD-1 blockade immunotherapy | Abril-Rodriguez G, Torrejon DY, Liu W, Zaretsky JM, Nowick TS, Tsoi J, Puig-Saus C, Baselga-Carretero I, Medina E, Quist MJ, Garcia AJ, Senapedis W, Baloglu E, Kalbasi A, Cheung-Lau G, Berent-Maoz B, Comin-Anduix B, Hu-Lieskovan S, Wang C-Y, Grasso CS, Ribas A | 2019 | Nature Cancer | Immuno-oncology | HALO | |
Histological characterization of aldosterone-producing adrenocortical adenomas with different somatic mutations | Acosta-Ruiz A, Gutzeit VA, Skelly MJ, Meadows S, Lee J, Parekh P, Orr AG, Liston C, Pleil KE, Broichhagan J, Levitz J | 2019 | Neuron | Neuroscience | HALO | |
Amyloid-Beta (A?) Plaques Promote Seeding and Spreading of Alpha-Synuclein and Tau in a Mouse Model of Lewy Body Disorders with A? Pathology | Bassil F, Brown HJ, Pattabhiraman S, Iwasyk JE, Maghames CM, Meymand ES, Cox TO, Riddle FM, BinZhang N, Trojanowski JQ, Lee VM-Y | 2019 | Neuron | Neuroscience | HALO | |
Rabbit monoclonal E?cadherin antibody: A cost?effective alternative to mouse monoclonal antibody in distinguishing ductal carcinoma in situ from lobular carcinoma in situ | Baum JE, Croyle JA, Brodsky VB, Liu Y, Shin SJ | 2019 | The Breast Journal | Oncology | Cytonuclear | HALO |
MAPKAPK2 (MK2) inhibition mediates radiation-induced inflammatory cytokine production and tumor growth in head and neck squamous cell carcinoma | Berggren KL, Cruz SR, Hixon MD, Cowan AT, Keysar SB, Craig S, James J, Barry M, Ozbun MA, Jimeno A, McCance DJ, Beswick EJ, Gan GN | 2019 | Oncogene | Oncology | Cytonuclear, Figure Maker | HALO |
Pre-diagnostic anthropometry, sex, and risk of colorectal cancer according to tumor immune cell composition | Berntsson J, Eberhard J, Nodin B, Leandersson K, Larsson AH, Eberhard J, Jirstrom K | 2019 | OncoImmunology | Immuno-oncology | HALO | |
Single cell transcriptomic profiling of large intestinal enteroendocrine cells in mice - Identification of selective stimuli for insulin-like peptide-5 and glucagon-like peptide-1 co-expressing cells | Billing LJ, Larraufie P, Lewis J, Leiter A, Li J, Lam B, Yeo GSH, Goldspink DA, Kay RG, Gribble FM, Reimann F | 2019 | Molecular Metabolism | Metabolism | HALO | |
Genetic mutations underlying phenotypic plasticity in basosquamous carcinoma | Chiang A, Tan CZ, Kuonen F, Hodgkinson LM, Chiang F, Cho RJ, South AP, Tang Jean Y, Chang ALS, Rieger KE, Oro AE, Sarin KY | 2019 | Journal of Investigative Dermatology | Oncology | Cytonuclear | HALO |
Kras and Lkb1 mutations synergistically induce intraductal papillary mucinous neoplasm derived from pancreatic duct cells | Collet L, Ghurburrun E, Meyers N, Assi M, Pirlot B, Leclercq IA, Couvelard A, Komuta M, Cros J, Demetter P, Lemaigre FP, Borbath I, Jacquemin P | 2019 | Gut | Oncology | HALO | |
Next-generation computational tools for interrogating cancer immunity | Finotello F, Rieder D, Hackl H, Trajanoski Z | 2019 | Nature Reviews Genetics | Review | HALO | |
The crosstalk between aldosterone and calcium metabolism in primary aldosteronism: A possible calcium metabolism-associated aberrant neoplastic steroidogenesis in adrenals | Gao X, Yamazaki Y, Tezuka Y, Onodera Y, Ogata H, Omata K, Morimoto R, Nakamura Y, Satoh F, Sasano H | 2019 | The Journal of Steroid Biochemistry and Molecular Biology | Oncology, Metabolism | Cytonuclear | HALO |
Farnesoid X Receptor Agonism, AcetylCoenzyme A Carboxylase Inhibition, and Back Translation of Clinically Observed Endpoints of De Novo Lipogenesis in a Murine NASH Model | Gapp B, Jourdain M, Bringer P, Kueng B, Weber D, Osmont A, Zurbruegg S, Knehr J, Falchetto R, Roma G, Dietrich W, Valdez R, Beckmann N, Nigsch F, Sanyal AJ, Ksiazek I | 2019 | Hepatology Communications | Metabolism | Cytonuclear | HALO |
Open radial artery harvesting better preserves endothelial function compared to the endoscopic approach | Gaudino MF, Lorusso R, Ohmes LB, Narula N, McIntire PJ, Gargiulo A, Bucci MR, Leonard J, Rahouma M, Di Franco A, He GW, Girardi LN, Tranbaugh RF, Di Lorenzo A | 2019 | Interactive CardioVascular and Thoracic Surgery | HALO | ||
Dynamic changes to lipid mediators support transitions among macrophage subtypes during muscle regeneration | Giannakis N, Sansbury BE, Patsalos A, Hays TT, Riley CO, Han X, Spite M, Nagy L | 2019 | Nature Immunology | Immunology, Myology | Muscle Fiber | HALO |
Evaluation of Peritumoral Fibrosis in Metastatic Colorectal Adenocarcinoma to the Liver Using Digital Image Analysis | Waters KM, Cottrell TR, Besharati S, Zhu Q, Anders RA | 2019 | American Journal of Clinical Pathology | Oncology | Area Quantification, Partitions (tiles, margins) | HALO |
Cross-Platform Comparison of Computer-assisted Image Analysis Quantification of In Situ mRNA Hybridization in Investigative Pathology. | Holzer TR, Hanson JC, Wray EM, Bailey JA, Kennedy KR, Finnegan PR, Nasir A, Credille KM | 2019 | Applied Immunohistochemistry & Molecular Morpholgy | HALO | ||
Oral tenofovir disoproxil fumarate/emtricitabine for HIV pre-exposure prophylaxis increases expression of type I/III interferon-stimulated factors in the gastrointestinal tract but not in the blood | Hughes SM, Levy CN, Calienes F, Stekler JD, Pandey U, Vojtech L, Berard AR, Birse K, Noel-Romas L, Richardson B, Golden J, Cartwright M, Collier AC, Stevens CE, Curlin ME, Holtz TH, Mugo N, Irungu E, Katabira E, Muwonge T, Lama JR, Baeten JM, Burgener A, Lingappa JR, McElrath MJ, Mackelprang R, McGowan I, Cranston RD, Cameron MJ, Hladik F | 2019 | bioRxiv | Infectious Disease | Cytonuclear | HALO |
Intraintestinal and Parenteral Administration of an Insulin Analogue Leads to Comparable Activation of Signaling Downstream of the Insulin Receptor in the Small Intestine | Hvid H, Kildegaard J, Kristensen K, Porsgaard T, Jørgensen MS, Ballarín-González B, Ahnfelt-Rønne J, Hansen Bo F, Nishimura E | 2019 | Journal of Diabetes Science and Technology | Metabolism | HALO | |
Epithelial NOTCH Signaling Rewires the Tumor Microenvironment of Colorectal Cancer to Drive Poor-Prognosis Subtypes and Metastasis | Jackstadt R, van Hooff ST, Leach JD, Cortes-Lavaud X, Lohuis JO, Ridgway RA, Wouters VM, JatinRoper J, Kendall TJ, Roxburgh CS, Horgan PG, Nixon C, Nourse C, Gunzer M, Clark W, Hedley A, Yilmaz OH, Rashid M, Bailey P, Biankin AV, Campbell AD, Adams DJ, Barry ST, Steele CW, Medema JP, Sansom OJ | 2019 | Cancer Cell | Oncology | HALO | |
Expression of avian ?-defensin mRNA in the chicken yolk sac | Zhang H, Wong EA | 2019 | Developmental & Comparative Immunology | Immunology | ISH/FISH | HALO |
Lenvatinib plus anti-PD-1 antibody combination treatment activates CD8+ T cells through reduction of tumor-associated macrophage and activation of the interferon pathway | Kato Y, Tabata K, Kimura T, Yachie-Kinoshita A, Ozawa Y, Yamada K, Ito J, Tachino S, Hori Y, Matsuki M, Matsuoka Y, Ghosh S, Kitano H, Nomoto K, Matsui J, Funahashi Y | 2019 | PLOS One | Immuno-oncology | HALO | |
Calpain 9 as a therapeutic target in TGF?-induced mesenchymal transition and fibrosis | Kim DH, Beckett JD, Nagpal V, Seman-Senderos MA, Gould Russell A, Creamer TJ, MacFarlane EG, Chen Y, Bedja D, Butcher JT, Mitzner W, Rouf R, Hata S, Warren DS, Dietz HC | 2019 | Science Translational Medicine | Fibrosis | HALO | |
Delayed Azithromycin Treatment Improves Recovery After Mouse Spinal Cord Injury | Kopper TJ, McFarlane KE, Bailey WM, Orr MB, Zhang B, Gensel JC | 2019 | Frontiers in Ceullar Neuroscience | Neuroscience | HALO | |
Long-Term Persistence of Anti-HIV Broadly Neutralizing Antibody-Secreting Hematopoietic Cells in Humanized Mice | Kuhlmann A-S, Haworth KG, Barber-Axthelm IM, Ironside C, Giese MA, Peterson CW, Kiem H-P | 2019 | Molecular Therapy | Infectious Disease | HALO | |
Temporal Analysis of Amylase Expression in Control, Autoantibody Positive, and Type 1 Diabetes Pancreatic Tissues | Kusmartseva I, Beery M, Hiller H, Padilla M, Selman S, Posgai A, Nick HS, Campbell-Thompson M, Schatz DA, Haller MJ, Wasserfall CH, Atkinson MA | 2019 | Diabetes | Metabolism | HALO | |
Phosphorylation of connexin 43 at MAPK, PKC or CK1 sites each distinctly alter the kinetics of epidermal wound repair | Lastwika JK, Dunn CA, Solan JL, Lampe PD | 2019 | Journal of Cell Science | HALO | ||
Active Cushing's Disease is Characterized by Increased Adipose Tissue Macrophage Presence | Lee IT, Atuahene A, Egritag HE, Buettner C, Wang L, Geer EB, Donovan M | 2019 | The Journal of Clinical Endocrinology & Metabolism | Metabolism | HALO | |
Impact of a Pre-Operative Exercise Intervention on Breast Cancer Proliferation and Gene Expression: Results from the Pre-Operative Health and Body (PreHAB) Study | Ligibel JA, Dillon D, Giobbie-Hurder A, McTiernan A, Frank E, Cornwell M, Pun M, Campbell N, Dowling RJO, Chang MC, Tolaney S, Chagpar AB, Yung RL, Freedman RA, Dominici LS, Golshan M, Rhei E, Taneja K, Huang Y, Brown M, Winer EP, Jeselsohn R, Irwin ML | 2019 | Clinical Cancer Research | HALO | ||
A phase 2 study of GVAX colon vaccine with cyclophosphamide and pembrolizumab in patients with mismatch repair proficient advanced colorectal cancer | Yarchoan M, Huang C-Y, Zhu Q, Ferguson AK, Durham JN, Anders RA, Thompson ED, Rozich NS, Thomas DL, Nauroth JM, Rodriguez C, Osipov A, De Jesus-Acosta A, Le DT, Murphy AG, Laheru D, Donehower RC, Jaffee EM, Zheng L, Azad NS | 2019 | Cancer Medicine | Immuno-oncology | Area Quantification, Partitions (tiles, margins) | HALO |
Hotspot enumeration of CD8+ tumor infiltrating lymphocyte using digital image analysis in triple negative breast Cancer yields consistent results | McIntire PJ, Zhong E, Patel A, Khani F, D'Alfonso T, Chen Z, Shin SJ, Ginter PS | 2019 | Human Pathology | Oncology | Cytonuclear | HALO |
Female-biased embryonic death from inflammation induced by genomic instability | McNairn AJ, Chuang C-H, Bloom JC, Wallace MD, Schimenti JC | 2019 | Nature | Immunology | Cytonuclear | HALO |
Imaging CAR T cell therapy with PSMA-targeted positron emission tomography | Minn I, Huss DJ, Ahn H-H, Chinn TM, Park A, Jones J, Brummet M, Rowe SP, Sysa-Shah P, Du Y, Levitsky HI, Pomper MG | 2019 | Science Advances | Oncology | Cytonuclear | HALO |
Reliable identification of prostate cancer using mass spectrometry metabolomic imaging in needle core biopsies | Morse N, Jamaspishvili T, Simon D, Patel PG, Ren KYM, Wang J, Oleschuk R, Kaufmann M, Gooding RJ, Berman DM | 2019 | Laboratory Invesigations | Oncology | HALO | |
Efficacy of ruthenium coordination complex-based Rutherrin in a preclinical rat glioblastoma model | Munegowda MA, Fisher C, Molehuis D, Foltz W, Roufaiel M, Bassan J, Nitz M, Mandel A, Lilge L | 2019 | Neuro-Oncology Advances | HALO | ||
HIF-independent synthetic lethality between CDK4/6 inhibition and VHL loss across species | Nicholson HE, Tariq Z, Housden BE, Jennings RB, Stransky LA, Perrimon N, Signoretti S, Kaelin WG | 2019 | Cancer Therapy | HALO | ||
Prohibitin is a prognostic marker of relapse and therapeutic target to block chemotherapy resistance in Wilms tumor | Ortiz MV, Ahmed S, Burns M, Henssen AG, Hollmann TJ, MacArthur I, Gunasekera S, Gaewsky L, Bradwin G, Ryan J, Letai A, He Y, Naranjo A, Chi Y-Y, LaQuaglia M, Heaton T, Cifani P, Dome JS, Gadd S, Perlman E, Mullen E, Steen H, Kentsis A | 2019 | JCI Insight | Oncology | Cytonuclear | HALO |
Validation and characterisation of prognostically significant PD-L1+ immune cells in HPV+ oropharyngeal squamous cell carcinoma | Young RJ, Bressel M, Porceddu S, Cernelc J, Savas P, Liu H, Urban D, Thai AA, Cooper C, Fua T, Neeson P, Rischin D, Solomon B | 2019 | Oral Oncology | Oncology, Infectious Disease | Classifier, Highplex FL | HALO |
Human 3D Gastrointestinal Microtissue Barrier Function As a Predictor of Drug-Induced Diarrhea | Peters MF, Landry T, Pin C, Maratea K, Dick C, Wagoner MP, Choy AL, Barthlow H, Snow D, Stevens Z, Armento A, Scott CW, Ayehunie S | 2019 | Toxicological Sciences | Gastroenterology | HALO | |
PTEN loss in Gleason grade 7 prostate tumors exhibits intratumoral heterogeneity and is associated with unfavorable pathological features | Picanço-Albuquerque CG, Vidotto T, Pereira CS, Saggioro FP, Jamaspishvili T, Koti M, Berman DM, Squire JA, Reis RB | 2019 | Applied Cancer Research | Oncology | HALO | |
Extramammary Paget disease shows differential expression of B7 family members B7-H3, B7-H4, PD-L1, PD-L2 and cancer/testis antigens NY-ESO-1 and MAGE-A | Pourmaleki M, Young JH, Socci ND, Chiang S, Edelweiss M, Li Y, Zhang M, Roshal L, Chi DS, Busam KJ, Mellinghoff IK, Hollmann TJ | 2019 | Oncotarget | HALO | ||
Impact of TREM2 risk variants on brain region-specific immune activation and plaque microenvironment in Alzheimer's disease patient brain samples | Prokop S, Miller KR, Labra SR, Pitkin RM, Hoxha K, Narasimhan S, Changolkar L, Rosenbloom A, Lee VM-Y, Trojanowski JQ | 2019 | Acta Neuropathologica | Neuroscience | HALO | |
Delta-like protein 3 expression and therapeutic targeting in neuroendocrine prostate cancer | Puca L, Gavyert K, Sailer V, Conteduca V, Dardenne E, Sigouros M, Isse K, Kearney M, Vosoughi A, Fernandez L, Pan H, Motanagh S, Hess J, Donoghue AJ, Sboner A, Wang Y, Dittamore R, Rickman D, Nanus DM, Tagawa ST, Elemento O, Mosquera JM, Saunders L, Beltran H | 2019 | Science Translational Medicine | Oncology | HALO | |
Mitogenic and progenitor gene programmes in single pilocytic astrocytoma cells | Reitman ZJ, Paolella BR, Bergthold G, Pelton K, Becker S, Jones R, Sinai CE, Malkin H, Huang Y, Grimmet L, Herbert ZT, Sun Y, Weatherbee JL, Alberta JA, Daley JF, Rozenblatt-Rosen O, Condurat AL, Qian K, Khadka P, Segal RA, Haas-Kogan D, Filbin MG, Suva ML, Regev A, Stiles CD, Kieran MW, Goumnerova L, Ligon KL, Shalek AK, Bandopadhayay P, Beroukhim R | 2019 | Nature Communications | Oncology | HALO | |
Pre-exposure prophylaxis differentially alters circulating and mucosal immune cell activation in herpes simplex virus type 2 seropositive women | Richert-Spuhler LE, Pattacini L, Plews M, Irungu E, Muwonge TR, Katabira E, Mugo N, Meyers AFA, Celum C, Baeten JM, Lingappa JR, Lund JM | 2019 | AIDS | Infectious Disease | HALO | |
A MYCGCN2eIF2? negative feedback loop limits protein synthesis to prevent MYC-dependent apoptosis in colorectal cancer | Schmidt S, Gay D, Uthe FW, Denk S, Paauwe M, Matthes N, Diefenbacher ME, Bryson S, Warrander FC, Erhard F, Ade CP, Baluapuri A, Walz S, Jackstadt R, Ford C, Vlachogiannis G, Valeri N, Otto C, Schülein-Völk C, Maurus K, Schmitz W, Knight JRP, Wolf E, Strathdee D, Schulze A, Germer C-T, Rosenwald A, Sansom OJ, Eilers M | 2019 | Nature Cell Biology | Oncology | HALO | |
Mobilization of CD8+ T cells via CXCR4 blockade facilitates PD-1 checkpoint therapy in human pancreatic cancer | Seo YD, Jiang X, Sullivan KM, Jalikis FG, Smythe KS, Abbasi A, Vignali M, Park JO, Daniel SK, Pollack SM, Kim TS, Yeung R, Crispe IN, Pierce RH, Robins H, Pillarisetty VG | 2019 | Clinical Cancer Research | Immuno-oncology | HALO | |
Targeting glutamate metabolism in melanoma | Singh S, Shah R, Chen S, Filipp FV | 2019 | arXiv | HALO | ||
Logic-Gated ROR1 Chimeric Antigen Receptor Expression Rescues T Cell-Mediated Toxicity to Normal Tissues and Enables Selective Tumor Targeting | Srivastava S, Salter A, Liggitt D, Yechan-Gunja S, Sarvothama M, Cooper K, Smythe KS, Dudakov JA, Pierce RH, Rader C, Riddell SR | 2019 | Cancer Cell | Oncology, Immuno-oncology | HALO | |
Citrullination of fibronectin alters integrin clustering and focal adhesion stability promoting stromal cell invasion | Stefanelli VL, Choudhury S, Hu P, Liu Y, Schwenzer A, Yeh C-R, Chambers DM, Pesson K, Li W, Segura T, Midwood KS, Torres M, Barker TH | 2019 | Matrix Biology | Oncology, Fibrosis | HALO | |
A Short Isoform of Coagulation Factor XII mRNA Is Expressed by Neurons in the Human Brainl | Zamolodchikov D, Bai Y, Tang Y, McWhirter JR, Macdonald LE, Alessandri-Haber N | 2019 | Neuroscience | Neuroscience | Figure Maker | HALO |
Automated macrophage counting in DLBCL tissue samples: a ROF filter based approach | Wagner M, Hansel R, Reinke S, Richter J, Altenbuchinger M, Braumann U-D, Spang R, Loffler Mk Klapper W | 2019 | Biological Proectures Online | Oncology | Object Colocalization | HALO |
Impact of pre?therapy glioblastoma multiforme microenvironment on clinical response to autologous CMV?specific T?cell therapy | Walker DG, Shakya R, Morrison B, Neller MA, Matthews KK, Nicholls J, Smith C, Khanna R | 2019 | Clinical & Translational Immunology | Immuno-oncology | Classifier | HALO |
Human pseudoislet system enables detection of differences in G-protein-coupledreceptor signaling pathways between ? and ? cells | Walker JT, Haliyur R, Nelson HA, Ishahak M, Poffenberger G, Aramandla R, Reihsmann C, Luchsinger JR, Saunders DC, Wang P, Garcia-Ocana A, Bottino R, Agarwal A, Powers AC, Brissove M | 2019 | bioRxiv | HALO | ||
Multiplex Immunofluorescence of Bone Marrow Core Biopsies: Visualizing the Bone Marrow Immune Contexture | Walters DK, Jelinek DF | 2019 | Journal of Histochemistry & Cytochemistry | HALO | ||
No Evidence of Neurogenesis in Adult Rat Sympathetic Ganglia Following Guanethidine-Induced Neuronal Loss | Walters KM, Boucher M, Boucher GG, Opsahl AC, Mouton PR, Liu C-N, Ritenour CR, Kawabe TT, Pryski HN, Somps CJ | 2019 | Toxicologic Pathology | Toxicology, Neuroscience | HALO | |
ATDC is required for the initiation of KRAS-induced pancreatic tumorigenesis | Wang L, Yang H, Zamperone A, Diolaiti D, Palmbos PL, Abel EV, Purohit V, Dolgalev I, Rhim AD, Ljungman M, Hadju CH, Halbrook CJ, Bar-Sagi D, di Magliano MP, Crawford HC, Simeone DM | 2019 | Genes & Development | Oncology | HALO | |
Monocytes/Macrophages play a pathogenic role in IL-23 mediated psoriasis-like skin inflammation | Wang Y, Edelmayer R, Wetter J, Salte K, Gauvin D, Leys L, Paulsboe S, Su Z, Weinberg I, Namovic M, Gauld SB, Honore P, Scott VE, McGaraughty S | 2019 | Scientific Reports | Immunology, Dermatology | HALO | |
Myeloid Cell-Derived HB-EGF Drives Tissue Recovery After Pancreatitis | Wen H-J, Gao S, Wang Y, Ray M, Magnuson MA, Wright CVE, Di Magliano MP, Frankel TL, Crawford HC | 2019 | Cellular and Molecular Gastroenterology and Hepatology | Immunology | HALO | |
Nrf2 represses the onset of type 1 diabetes in non-obese diabetic mice | Yagishita Y, Uruno A, Chartoumpekis DV, Kensler TW, Yamamoto M | 2019 | The Journal of Endocrinology | Metabolism | HALO | |
Systemic mRNA Therapy for the Treatment of Fabry Disease: Preclinical Studies in Wild-Type Mice, Fabry Mouse Model, and Wild-Type Non-human Primates | Zhu S, Li S, Escuin-Ordinas H, Dimatteo R, Xia W, Ribas A, Segura T | 2019 | The American Journal of Human Genetics | Metabolism | HALO | |
Selective modulation of the androgen receptor AF2 domain rescues degeneration in spinal bulbar muscular atrophy | Badders NM, Korff A, Miranda HC, Vuppala PK, Smith RB, Winborn BJ, Quemin ER, Sopher BL, Dearman J, Messing J, Kim NC, Moore J, Freibaum BD, Kanagaraj AP, Fan B, Tillman H, Chen P-C, Wang Y, Freeman BB, Li Y, Kim HJ, La Spada AR, Taylor JP | 2018 | Nature Medicine | Myology | Area Quantification | HALO |
Anti-NKG2A mAb Is a Checkpoint Inhibitor that Promotes Anti-tumor Immunity by Unleashing Both T and NK Cells | Andre ?P, Denis C, Soulas C, Bourbon-Caillet C, Lopez J, Arnoux T, Ble?ry M, Bonnafous C, Gauthier L, Morel A, Rossi B, Remark R, Breso V, Bonnet E, Habif G, Guia S, Lalanne AI, Hoffmann C, Lantz O, Fayette J, Boyer-Chammard A, Zerbib R, Dodion P, Ghadially H, Jure-Kunkel M, Morel Y, Herbst R, Narni-Mancinelli E, Cohen RB, Vivier E | 2018 | Cell | Oncology, Immuno-oncology | Area Quantification, Cytonuclear | HALO |
Tuning of delta-protocadherin adhesion through combinatorial | Bisogni AJ, Ghazanfar S, Williams EO, Marsh HM, Yang JYH, Lin DM | 2018 | eLife | Neuroscience | Area Quantification | HALO |
RAD51 foci as a functional biomarker of homologous recombination repair and PARP inhibitor resistance in germline BRCA mutated breast cancer | Cruz C, Castroviejo-Bermejo M, Gutiérrez-Enríquez S, Llop-Guevara A, Ibrahim YH, Gris-Oliver A, Bonache S, Morancho B, Bruna A, Rueda OM, Lai Z, Polanska UM, Jones GN,Kristel P, de Bustos L, Guzman M, Rodriguez O, Grueso J, Montalban G, Caratú G, Mancuso F, Fasani R, Jiménez J, Howat WJ, Dougherty B, Vivancos A, Nuciforo P, Serres-Créixams X, Rubio IT, Oaknin A, Cadogan O, Barrett JC, Caldas C, Baselga J, Saura C, Cortés J, Arribas J, Jonkers J, Díez O, OConnor MJ, Balmaña J, SerraV | 2018 | Annals of Oncology | Oncology | Classifier, Cytonuclear | HALO |
The brain-penetrant clinical ATM inhibitor AZD1390 radiosensitizes and improves survival of preclinical brain tumor models | Durant ST, Zheng L, Wang Y, Chen K, Zhang L, Zhang T, Yang Z, Riches L, Trinidad AG, Fok JHL, Hunt T, Pike KG, Wilson J, Smith A, Colclough N, Reddy VP, Sykes A, Janefeldt A, Johnström P, Varnäs K, Takano A, Ling S, Orme J, Stott J, Roberts C, Barrett I, Jones G, Roudier M, Pierce A, Allen J, Kahn J, Sule A, Karlin J, Cronin A, Chapman M, Valerie K, Illingworth R, Pass M | 2018 | Science Advances | Oncology, Neuroscience | Classifier, Cytonuclear | HALO |
High response rate to PD-1 blockade in desmoplastic melanomas | Eroglu Z, Zaretsky JM, Hu-Lieskovan H, Kim DW, Algazi A, Johnson DB, Liniker E, Kong B, Munhoz R, Rapisuwon S, Gherardini PF, Chmielowski B, Wang X, Shintaku IP, Wei C, Sosman JA, Joseph RW, Postow MA, Carlino MS, Hwu W-J, Scolyer RA, Messina J, Cochran AJ, Long GV, Ribas A | 2018 | Nature | Oncology, Immuno-oncology | Cytonuclear | HALO |
Early Stage HER2-Positive Breast Cancers Not Achieving a pCR From Neoadjuvant Trastuzumab- or Pertuzumab-Based Regimens Have an Immunosuppressive Phenotype | Force J, Howie LJ, Abbot SE, Bentley R, Marcom PK, Kimmick G, Westbrook K, Sammons SL, Parks M, Topping DL, Emerson R, Broadwater G, Hyslop T, Blackwell KL, Nair SK | 2018 | Clinical Breast Cancer | Oncology, Immuno-oncology | Cytonuclear | HALO |
Bortezomib prevents cytarabine resistance in MCL, which is characterized by down-regulation of dCK and up-regulation of SPIB resulting in high NF-?B activity | Freiburghaus C, Emruli VK, Johansson A, Eskelund CW, Grønbæk K, Olsson R, Ek F, Jerkeman M, Ek S | 2018 | BMC Cancer | Oncology | Classifier, Cytonuclear | HALO |
The novel ATM inhbitior (AZ31) enhances antitumor activity in patient derived xenografts that are resistant to irinotecan montherapy | Greene J, Nguyen A, Bagby SM, Jones GN, Tai WM, Quackenbush KS, Schreiber A, Messersmith WA, Devaraj KM, Blatchford P, Eckhardt SG, Cadogan EB, Hughes GD, Smith A, Pitts TM, Arcaroli JJ | 2018 | Oncotarget | Oncology | Classifier, Area Quantification, Cytonuclear | HALO |
Cystic fibrosisrelated diabetes is caused by islet loss and inflammation | Hart NJ, Aramandla R, Poffenberger G, Fayolle C, Thames AH, Bautista A, Spigelman AF, Babon JAB, DeNicola ME, Dadi PK, Bush WS, Balamurugan AN, Brissova M, Dai C, Prasad N, Bottino R, Jacobson DA, Drumm ML, Kent SC, MacDonald PE, Powers AC | 2018 | JHI Insights | Immunology, Metabolism, Fibrosis | Cytonuclear | HALO |
Attenuation of diet-induced hypotalamic inflammation following bariatric surgery in female mice | Herrick MK, Favela KM, Simerly RB, Abumrad NN, Bingham NC | 2018 | Molecular Medicine | Immunology, Neuroscience | Cytonuclear | HALO |
pRAD50: a novel and clinically applicable pharmacodynamic biomarker of both ATM and ATR inhibition identified using mass spectrometry and immunohistochemistry | Jones GN, Rooney C, Griffin N, Roudier M, Young LA, Garcia-Trinidad A, Hughes GD, Whiteaker JR, Wilson Z, Odedra R, Zhao L, Ivey RG, Howat WJ, Harrington EA, Carrett JC, Ramos-Montoya A, Lau A, Paulovich AG, Cadogan EB, Pierce AJ | 2018 | British Journal of Cancer | Oncology | Classifier, Cytonuclear | HALO |
Mice harboring the human SLC30A8 R138X loss-of-function mutation have increased insulin secretory capacity | Kleinera S, Gomeza D, Megraa B, Naa E, Bhavsara R, Cavinoa K, Xina Y, Rojasa J, Dominguez-Gutierreza G, Zambrowicza B, Carratb G, Chabosseaub P, Hub M, Murphya AJ, Yancopoulosa GD, Rutterb GA, Gromadaa J | 2018 | Proceedings of the National Academy of Sciences | Metabolism | Cytonuclear | HALO |
TGF? inhibition restores a regenerative response in acute liver injury by suppressing paracrine senescence | Bird TG, Müller M, Boulter L, Vincent DF, Ridgway RA, Elena Lopez-Guadamillas E, Lu W-Y, Jamieson T, Govaere O, Campbell AD, Ferreira-Gonzalez S, Cole AM, Hay T, Simpson KJ, Clark W, Hedley A, Clarke M, Gentaz P, Nixon C, Bryce S, Kiourtis C, Sprangers J, Nibbs RJB, Van Rooijen N, Bartholin L, McGreal SR, Apte U, Barry ST, Iredale JP, Clarke AR, Serrano M, Roskams TA, Sansom OJ, Forbes SJ | 2018 | Science Translational Medicine | Metabolism | ISH/FISH | HALO |
Food Perception Primes Hepatic ER Homeostasis via Melanocortin-Dependent Control of mTOR Activation | Brandt C, Nolte H, Henschke S, Ruud LE, Awazawa M, Morgan DA, Gabel P, Sprenger H-G, Hess ME, Günther S, Langer T, Rahmouni K, Fenselau H, Krüger M, Brüning JC | 2018 | Cell | Neuroscience, Metabolism | ISH/FISH | HALO |
Gene Signature of Proliferating Human Pancreatic ?-Cells | Dominguez Gutierrez G, Xin Y, Okamoto H, Kim J, Lee A-H, Ni M, Adler C, Yancopoulos GD, Murphy AJ, Gromada J | 2018 | Endocrionology | Metabolism | ISH/FISH | HALO |
A phase II study of the dual mTOR inhibitor MLN0128 in patients with metastatic castration resistant prostate cancer | Graham L, Banda K, Torres A, Carver BS, Chen Y, Pisano K, Shelkey G, Curley T, Scher HI, Lotan TL, Hsieh AC, Rathkopf DE | 2018 | Investigational New Drugs | Oncology | ISH/FISH | HALO |
Ultrasensitive automated RNA in situ hybridization for kappa and lambda light chain mRNA detects B-cell clonality in tissue biopsies with performance comparable or superior to flow cytometry | Guo L, Wang Z, Anderson CA, Doolittle E, Kernag S, Cotta CV, Ondrejka SL, Ma X-J, Cook JR | 2018 | Modern Pathology | Other | Classifier, ISH/FISH | HALO |
CD163+ macrophages promote angiogenesis and vascular permeability accompanied by inflammation in atherosclerosis | Guo L, Akahori H, Harari E, Smith SL, Polavarapu R, Karmali V, Otsuka F, Gannon RL, Braumann RE, Dickinson MH, Gupta A, Jenkins AL, Lipinski MJ, Kim J, Chhour P, de Vries PS, Jinnouchi H, Kutys R, Mori H, Kutyna MD, Torii S, Sakamoto A, Choi CU, Cheng Q, Grove M, Mariem A. Sawan MA, Zhang Y, Cao Y, Kolodgie FD, Cormode DP, Arking DE, Boerwinkle E, Morrison AC, Erdmann J, Sotoodehnia N, Virmani R, and Finn AV | 2018 | The Journal of Clinical Investigation | Immunology | Layer Thickness | HALO |
Glucagon contibutes to liver zonation | Cheng X, Kim SK, Okamoto H, Xin Y, Yancopoulos GD, Murphy AJ, Gromada J | 2018 | Proceedings of the National Academy of Sciences | Metabolism | Area Quantification | HALO |
Evaluation of PD-L1 expression on vortex-isolated circulating tumor cells in metastatic lung cancer | Dhar M, Wong J, Che J, Matsumoto M, Grogan T, Elashof D, Garon EB, Goldman JW, Christen ES, Carlo DD, Kulkarni RP | 2018 | Scientific Reports | Oncology, Immuno-oncology | Area Quantification | HALO |
Digital image analysis of Ki67 proliferation index in breast cancer using virtual dual staining on whole tissue sections: clinical validation and inter?platform agreement | Koopman T, Buikema HJ, Hollema H, de Bock GH, van der Vegt B | 2018 | Breast Cancer Research and Treatment | Oncology | Classifier, Cytonuclear | HALO |
The neurotrophic tyrosine kinase receptor TrkA and its ligand NGF are increased in squamous cell carcinomas of the lung | Gao F, Griffin N, Faulkner S, Rowe CW, Williams L, Roselli S, Thorne RF, Ferdoush A, Jobling P, Walker MM, Hondermarck H | 2018 | Scientific Reports | Oncology | Area Quantification | HALO |
Ovarian Tumor Microenvironment Signaling: Convergence on the Rac1 GTPase | Hudson LG, Gillette JM, Kang H, Rivera MR, Wandinger-Ness A | 2018 | Cancers | Review | Classifier, Cytonuclear, Figure Maker | HALO |
A murine glaucoma model induced by rapid in vivo photopolymerization of hyaluronic acid glycidyl methacrylate | Guo C, Qu X, Rangaswamy N, Leehy B, Xiang C, Rice D, Prasanna G | 2018 | PLOS One | Biomaterials | Area Quantification | HALO |
Systemic messenger RNA as an etiological treatment for acute intermittent porphyria | Jiang L, Berraondo P, Jericó D, Guey LT, Sampedro A, Frassetto A, Benenato KE, Burke K, Santamaría E, Alegre M, Pejenaute A, Kalariya M, Butcher W, Park JS, Zhu X, Sabnis S, Kumarasinghe ES, Salerno T, Kenney M, Lukacs CM, Ávila MA, Martini PGV, Fontanellas A | 2018 | Nature Medicine | Metabolism | Area Quantification | HALO |
Tumor Microenvironment in Functional Adrenocortical Adenomas: Immune Cell Infiltration in Cortisol-producing Adrenocortical Adenoma | Kitawaki Y, Nakamura Y, Kubota-Nakayama F, YamazakiY, Miki Y, Hata S, Ise K, Kikuchie K, MorimotoR, Satoh F, Sasano H | 2018 | Human Pathology | Oncology, Immuno-oncology | Area Quantification | HALO |
Up-Regulation of Iba-1 and GFAP in the Acidic Saline Model of Chronic Widespread Musculoskeletal Pain: A Pilot Study Examining the Relationship Between Gliosis and Hyperalgesia | Lambert DM, Kumar U, Hafell UO | 2018 | Journal of Neuroscience and Neuropharmacology | Neuroscience | Area Quantification, Partitions (tiles, margins) | HALO |
Tough Composite Hydrogels with High Loading and Local Release of Biological Drugs | Li J, Weber E, Guth?Gundel S, Schuleit M, Kuttler A, Halleux C, Accart N, Doelemeyer A, Basler A, Tigani B, Wuersch K, Fornaro M, Kneissel M, Stafford A, Freedman BR, Mooney DJ | 2018 | Advanced Healthcare Materials | Biomaterials | Area Quantification | HALO |
Blocking HIF signaling via novel inhibitors of CA9 and APE1/Ref-1 dramatically affects pancreatic cancer cell survival | Logsdon DP, Fenil S, Fabrizio C, Supuran CT, Kamocka M, Jacobsen MH, Sandusky GE, Kelley MR, Fishel ML | 2018 | Scientific Reports | Oncology | Classifier, Cytonuclear | HALO |
Diet-Induced Growth Is Regulated via Acquired Leptin Resistance and Engages a PomcSomatostatin-Growth Hormone Circuit | Lohr H, Hess S, Pereira MMA, Reino P, Leibold S, Schenkel C, Wunderlich CM, Kloppenburg P, Bruning JC, Hammerschmidt M | 2018 | Cell Reports | Neuroscience, Metabolism | Cytonuclear | HALO |
Chronic Intermittent Hypoxia Induces Robust Astrogliosis in an Alzheimer's Disease-Relevant Mouse Model | Macheda T, Roberts K, Lyons DN, Higgins E, Ritter KJ, Lin A-L, Alilain WJ, Bachstetter AD | 2018 | Neuroscience | Neuroscience | Area Quantification | HALO |
Cellular milieu imparts distinct pathological ?-synuclein strains in ?-synucleinopathies | Peng C, Gathagan RJ, Covell DJ, Medellin C, Stieber A, Robinson JL, Zhang B, Pitkin RM, Olufemi MF, Luk KC, Trojanowski JQ, Lee VM-Y | 2018 | Nature | Neuroscience | Area Quantification | HALO |
Differential ?-synuclein expression contributes to selective vulnerability of hippocampal neuron subpopulations to fibril-induced toxicity | Luna E, Decker SC, Riddle DM, Caputo A, Zhang B, Cole T, Caswell C, Xie SX, Lee VMY, Luk KC | 2018 | Acta Neuopathologica | Neuroscience | Area Quantification, Cytonuclear | HALO |
Digital image analysis improves precision of PD?L1 scoring in cutaneous melanoma | Koelzer VH, Gisler A, Hanhart JC, Griss J, Wagner SN, Willi N, Cathomas G, Sachs M, Kempf W, Thommen DS, Mertz KD | 2018 | Histopathology | Oncology, Immuno-oncology | Classifier, Multiplex IHC | HALO |
Lenvatinib inhibits angiogenesis and tumor fibroblast growth factor signaling pathways in human hepatocellular carcinoma models | Matsuki M, Hoshi T, Yamamoto Y, Ikemori-Kawada M, Minoshima Y, Funahashi Y, Matsui J | 2018 | Cancer Medicine | Oncology | Cytonuclear | HALO |
Hot Spot and Whole-Tumor Enumeration of CD8(+) Tumor-Infiltrating Lymphocytes Utilizing Digital Image Analysis Is Prognostic in Triple-Negative Breast Cancer | McIntire PJ, Irshaid L, Liu Y, Chen Z, Menken F, Nowak E, Shin SJ, Ginter PS | 2018 | Clinical Breast Cancer | Oncology, Immuno-oncology | Cytonuclear, Figure Maker | HALO |
Altered dopaminergic regulation of the dorsal striatum is able to induce tic-like movements in juvenile rats | Nespoli E, Rizzo F, Boeckers T, Schulze U, Hengerer B | 2018 | PLOS One | Neuroscience | Cytonuclear | HALO |
Induction of hemangiosarcoma in mice after chronic treatment with S1P-modulator siponimod and its lack of relevance to rat and human | Pognan F, Mahl JA, Papoutsi M, David Ledieu D, Raccuglia M, Theil D, Voytek SB, Devine PJ, Kubek?Luck K, Claudio N, Cordier A, Heier A, Kolly C, Hartmann A, Chibout S-D, Bouchard P, Trendelenburg C | 2018 | Archives of Toxicology | Toxicology | Classifier, Cytonuclear | HALO |
Intermittent Hypoxia Exacerbates Increased Blood Pressure in Rats with Chronic Kidney Disease | Riggs J, Pace C, Ward HH, Gonzalez Bosc L, Rios L, Barrera A, Kanagy NL | 2018 | American Jornal of Physiology-Renal Physiology | Metabolism | Classifier, Cytonuclear | HALO |
Mild Impairment of Mitochondrial OXPHOS Promotes Fatty Acid Utilization in POMC Neurons and Improves Glucose Homeostasis in Obesity | Timper K, Paeger L, Sánchez-Lasheras C, Varela L, Jais A, Nolte H, Vogt MC, Hausen AC, Heilinger C, Evers N, Pospisilik JA, Penninger JM, Taylor EB, Horvath TL, Kloppenburg P, Brüning JC | 2018 | Cell Repots | Neuroscience, Metabolism | Cytonuclear | HALO |
Biomarker Evaluation and Toxic Effects of an Acute Oral and Systemic Fumonisin Exposure of Pigs with a Special Focus on Dietary Fumonisin Esterase Supplementation | Schertz H, Danicke S, Frahm J, Schatzmayr D, Dohnal I, Bichl G, Schwartz-Zimmerman HE, Colicchia S, Breves G, Teifke JP, Kluess J | 2018 | Toxins | Toxicology | Classifier | HALO |
Mutant myocilin impacts sarcomere ultrastructure in mouse gastrocnemius muscle | Lynch JM, Dolman AJ, Guo C, Dolan K, Xiang C, Reda S, Li B, Prasanna G | 2018 | PLOS One | Gastroenterology, Myology | ISH/FISH | HALO |
Breast and pancreatic cancer interrupt IRF8-dependent dendritic cell development to overcome immune surveillance | Meyer MA, Baer JM, Knolhoff BL, Nywening TM, Panni RZ, Su X, Weilbaecher KN, Hawkins WG, Ma C, Fields RC, Linehan DC, Challen GA, Faccio R, Aft RL, DeNardo DG | 2018 | Nature Communications | Oncology, Immuno-oncology | ISH/FISH | HALO |
What is the added value of digital image analysis of HER2 immunohistochemistry in breast cancer in clinical practice? A study with multiple platforms | Koopman T, Buikema HJ, Hollema H, de Bock GH, van der Vegt B | 2018 | Histopathology | Oncology | Membrane | HALO |
Tumor Cell Subtypes Based on the Intracellular Hormonal Activity in KCNJ5-Mutated Aldosterone-Producing Adenoma | Yamazaki Y, Omata K, Tezuka Y, Ono Y, Morimoto R, Adachi Y, Ise K, Nakamura Y, Gomez-Sanchez CE, Shibahara Y, Kitamoto T, Nishikawa T, Ito S, Satoh F, Sasano H | 2018 | Hypertension | Oncology | Area Quantification, Cytonuclear | HALO |
Disease Progression and Pharmacological Intervention in a Nutrient-Deficient Rat Model of Nonalcoholic Steatohepatitis | Tølbøl KS, Stierstorfer B, Rippmann JF, Veidal SS, Rigbolt KTG, Schönberger T, Gillum MP, Hansen HH, Vrang N, Jelsing J, Feigh M, Broermann A | 2018 | Digestive Diseases and Sciences | Metabolism | Area Quantification | HALO |
FOXM1 contributes to treatment failure in acute myeloid leukemia | Khan I, Halasi M, Patel A, Schultz R, Kalakota N, Chen Y-H, Aardsma N, Liu L, Crispino JD, Mahmud N, Frankfurt O, Gartel AL | 2018 | JCI Insight | Oncology | Multiplex IHC | HALO |
A transcriptionally and functionally distinct PD-1+ CD8+ T cell pool with predictive potential in non-small-cell lung cancer treated with PD-1 blockade | Thommen DS, Koelzer VH, Herzig P, Roller A, Trefny M, Dimeloe S, Kiialainen A, Hanhart J, Schil C, Hess C, Prince SS, Wiese M, Lardinois D, Ho P-C, Klein C, Karanikas V, Mertz KD, Schumacher TN, Zippelius A | 2018 | Nature Medicine | Oncology, Immuno-oncology | Multiplex IHC | HALO |
Relationship between mismatch repair immunophenotype and long-term survival in patients with resected periampullary adenocarcinoma | Heby M, Lundgren S, Nodin B, Elebro J, Eberhard J, Jirström K | 2018 | Journal of Translational Medicine | Oncology, Immuno-oncology | Object Colocalization | HALO |
Luminally-polarized mural and vascular remodeling in ileal strictures of Crohn's Disease | Zhang X, Ko HM, Torres J, Panchal HJ, Cai Z, WagneR M, Sands BE, Colombel J-F, Cho J, Taouli B, Harpaz N | 2018 | Human Pathology | Immunology | Layer Thickness | HALO |
Age-related pathology after adenoviral overexpression of the leucine-rich repeat kinase 2 in the mouse striatum | Kritzingerab A, Ferger B, Gillardon F, Stierstorfer B, Birk G, Kochanek S, Ciossek T | 2018 | Neurobiology of Aging | Neuroscience | Area Quantification, Object Colocalization, Microglia | HALO |
Pharmacogenetic neuronal stimulation increases human tau pathology and trans-synaptic spread of tau to distal brain regions in mice | Schultz MK, Gentzel R, Usenovic M, Gretzul C, Ware C, Parmentier-Batteur S, Schachter JB, Zariwala HA | 2018 | Neurobiology of Disease | Neuroscience | Object Colocalization | HALO |
Comparison of Biologic Effect and Particulate Embolization after Femoral Artery Treatment with Three Drug-Coated Balloons in Healthy Swine Model | Torii S, Jinnouchi H, Sakamoto A, Romero ME, Kolodgie FD, Virmani R, Finn AV | 2018 | Journal of Vascular and Interventional Radiology | Other | Object Colocalization | HALO |
Multidimensional, quantitative assessment of PD-1/PD-L1 expression in patients with Merkel cell carcinoma and association with response to pembrolizumab | Giraldo NA, Nguyen P, Engle EL, Kaunitz GJ, Cottrell TR, Berry S, Green B, Soni A, Cuda JD, Stein JE, Sunshine JC, Succaria F, Xu H, Ogurtsova A, Danilova L, Church CD, Miller NJ, Fling S, Lundgren L, Ramchurren N, Yearley JH, Lipson EJ, Cheever M, Anders RA, Nghiem PT, Topalian SL, Taube JM | 2018 | Journal for ImmunoTherapy of Cancer | Oncology, Immuno-oncology | Spatial Analysis, Serial Section | HALO |
A CD3-bispecific molecule targeting P-cadherin demonstrates T cell-mediated regression of established solid tumors in mice | TS Fisher, AT Hooper, J Lucas, TH Clark, AK Rohner, B Peano, MW Elliott, K Tsaparikos, H Wang, J Golas, M Gavriil, N Haddish-Berhane, L Tchistiakova, H-P Gerber, AR Root, C May | 2018 | Cancer Immunology, Immunotherapy | Oncology, Immuno-oncology | Area Quantification | HALO |
Innate Sex Bias of Staphylococcus aureus Skin Infection Is Driven by a-Hemolysin | Castleman MJ, Pokhrel S, Triplett KD, Kusewitt DF, Elmore BO, Joyner JA, Femling JK, Sharma G, Hathaway HJ, Prossnitz ER, Hall PR | 2018 | The Journal of Immunology | Infectious Disease | HALO | |
Subclonal evolution of pulmonary adenocarcinomas delineated by spatially distributed somatic mitochondrial mutations | Kazdal D, Harms A, Endris V, Penzel R, Kriegsmann M, Eichhorn F, Muley T, Stenzinger A, Pfarr N, Weichert W, and Warth A | 2018 | Lung Cancer | HALO | ||
Molecular and immunologic analysis of laryngeal squamous cell carcinoma in smokers and non-smokers | Malm I-J, rooper LM, Bishop JA, Ozgursoy SK, Hillel AT, Akst LM, Best SR | 2018 | American Journal of Otolaryngology | Oncology, Immuno-oncology | HALO | |
Class 4 Semaphorins and Plexin-B receptors regulate GABAergic and glutamatergic synapse development in the mammalian hippocampus | McDermott JE, Goldblatt D, Paradis S | 2018 | Molecular and Cellular Neuroscience | Neuroscience | HALO | |
Acquired cancer resistance to combination immunotherapy from transcriptional loss of class I HLA | Paulson KG, Voillet V, McAfee MS, Hunter DS, Wagener FD, Perdicchio, Valente WJ, Koelle SJ, Church CD, Vandeven N, Thomas H, Colunga AG, Iyer JG, Yee C, Kulikauskas R, Koelle DM, Pierce RH, Bielas JH, Greenberg PD, Bhatia S, Gottardo R, Nghiem P, Chapuis AG | 2018 | Nature Communications | Immuno-oncology | Partitions (tiles, margins), Figure Maker | HALO |
Digital image analysis supports a nuclear-to-cytoplasmic ratio cutoff value below 0.7 for positive for high-grade urothelial carcinoma and suspicious for high-grade urothelial carcinoma in urine cytology specimens | McIntire PJ, Snow JT, Elsoukkary SS, Soong L, Sweeney J, Robinson BD, Siddiqui MT | 2018 | Cancer Cytopathology | Oncology | HALO | |
Ossabaw Pigs With a PCSK9 Gain?of?Function Mutation Develop Accelerated Coronary Atherosclerotic Lesions: A Novel Model for Preclinical Studies | Yuan F, Guo L, Park K-H, Woollard JR, Taek?Geun K, Jiang K, Melkamu T, Zang B, Smith SL, Fahrenkrug SC, Kolodgie FD, Lerman A, Virmani R, Lerman LO, Carlson DF | 2018 | Journal of the American Heart Association | Myology | Area Quantification | HALO |
Accelerated wound healing by injectable star poly(ethylene)-b-poly(propylene sulfide) scaffolds loaded with poorly water-soluble drugs | Zhu X, Yin L, Theisen M, Zhuo J, Siddiqui S, Levy B, Presnyak V, Frassetto A, Milton J, Salerno T, Benenato KE, Milano J, Lynn A, Sabnis S, Burke K, Besin G, Lukacs CM, Guey LT, Finn PF, Martini PGV | 2018 | Journal of Controlled Release | Biomaterials, Wound Healing | Cytonuclear | HALO |
The use of automated Ki67 analysis to predict Oncotype DX risk-of-recurrence categories in early-stage breast cancer | Thakur SS, Li H, Chan AMY, Tudor R, Bigras G, Morris D, Enwere EK | 2018 | PLOS ONE | Oncology | Cytonuclear, Figure Maker, Partitions (tiles, margins) | HALO |
Inhibiting Interleukin 36 Receptor Signaling Reduces Fibrosis in Mice with Chronic Intestinal Inflammation | Scheibe K, Kersten C, Schmied A, Vieth M, Primbs T, Carlé B, Knieling F, Claussen J, Klimowicz AC, Zheng J, Baum P, Meyer S, Schürmann S, Friedrich O, Waldner MJ, Rath T, Wirtz S, Kollias G, Ekici AB, Atreya R, Raymond EL, Mbow ML, Neurath MF, Neufert C | 2018 | Gastroenterology | Immunology, Fibrosis | HALO | |
Low and variable tumor reactivity of the intratumoral TCR repertoire in human cancers | Scheper W, Kelderman S, Fanchi LF, Linnemann C, Bendle G, de Rooij MAJ, Hirt C, Mezzadra R, Slagter M, Dijkstra K, Kluin RJC, Snaebjornsson P, Milne K, Nelson BH, Zijlmans H, Kenter G, Voest EE, Haanen JBAG, Schumacher TN | 2018 | Nature Medicine | Oncology, Immuno-oncology | Cytonuclear | HALO |
A suboptimal maternal diet combined with accelerated postnatal growth results in an altered aging profile in the thymus of male rats | Tarry-Adkins JL, Aiken CE, Ashmore TJ, Fernandez-Twinn DS, Chen J-H, Ozanne SE | 2018 | The FASEB Journal | Neuroscience, Metabolism | Classifier, Vacuole | HALO |
A brain-penetrant triazolopyrimidine enhances microtubule-stability, reduces axonal dysfunction and decreases tau pathology in a mouse tauopathy model. | Zhang B, Yao Y, Cornec A-S, Oukoloff K, James MJ, Koivula P, Trojanowski JQ, Smith AB III, Lee VM-Y, Ballatore C, Brunden KR | 2018 | Molecular Neurodegeneration | Neuroscience | Area Quantification | HALO |
GABA promotes ?-cell proliferation, but does not overcome impaired glucose homeostasis associated with diet-induced obesity | Untereiner A, Abdo S, Bhattacharjee A, Gohil H, Pourasgari F, Ibeh N, Lai M, Batchuluun B, Wong A, Khuu N, Liu Y, Rijjal DA, Winegarden N, Virtanen C, Orser BA, Cabrera O, Varga G, Rocheleau J, Dai FF, Wheeler MB | 2018 | The FASEB Journal | Metabolism | Cytonuclear | HALO |
Ki67 reproducibility using digital image analysis: an inter-platform and inter-operator study | Acs B, Pelekanou V, Bai Y, Martinez-Morilla S, Toki M, Leung SCY, Nielsen TO, Rimm DL | 2017 | Laboratory Invesigations | Oncology | Classifier, Cytonuclear | HALO |
Efficacy of injectable praziquantel for elimination of trematode metacercariae in bluegills (Lepomis macrochirus) and quantification of parasite death by propidium iodide staining | Bader C, Chelladurai JJ, Starling DE, Jones DE, Brewer MT | 2017 | Parasitology Research | Infectious Disease | Area Quantification | HALO |
Both brown adipose tissue and skeletal muscle thermogenesis processes are activated during mild to severe cold adaptation in mice | Bal NC, Singh S, Reis FCG, Maurya SK, Pani S, Rowland LA, Periasamy M | 2017 | Journal of Biological Chemistry | Myology | Area Quantification | HALO |
Sex- and Dose-Specific Effects of Maternal Bisphenol A Exposure on Pancreatic Islets of First- and Second-Generation Adult Mice Offspring | Bansal A, Rashid C, Xin F, Li C, Polyak E, Duemler A, van der Meer T, Stefaniak M, Wajid S, Doliba N, Bartolomei MS, Simmons RA | 2017 | Environmental Health Perspectives | Metabolism | Area Quantification | HALO |
The R-enantiomer of ketorolac delays mammary tumor development in mouse mammary tumor virus-polyoma middle T antigen (MMTV-PyMT) mice | AS Peretti, D Dominguez, MM Grimes, HJ Hathaway, ER Prossnitz, MR Rivera, A Wandinger-Ness, D Kusewitt, LG Hudson | 2017 | The American Journal of Pathology | Oncology | Classifier, Area Quantification, Cytonuclear | HALO |
The clinical impact of tumour-infiltrating lymphocytes in colorectal cancer differs by anatomical subsite: A cohort study | Berntsson J, Svensson MC, Leandersson K, Nodin B, Micke P, Larsson AH, Eberhard J, Jirstrom K | 2017 | International Journal of Cancer | Oncology, Immuno-oncology | Cytonuclear | HALO |
Acetate Recapturing by Nuclear Acetyl-CoA Synthetase 2 Prevents Loss of Histone Acetylation during Oxygen and Serum Limitation | Bulusu V, Tumanov S, Michalopoulou E, van den Broek NJ, MacKay G, Nixon C, Dhayade S, Schug ZT, Voorde JV, Blyth K, Gottlieb E, Vazquez A, Kamphorst JJ | 2017 | Cell Reports | Oncology, Metabolism | Cytonuclear | HALO |
Loss of the imprinted, non-coding Snord116 gene cluster in the interval deleted in the Prader Willi syndrome results in murine neuronal and endocrine pancreatic developmental phenotypes | Burnett LC, Hubner G, LeDuc C, Morabito MV, Carli JFM, Leibel RL | 2017 | Human Moledular Genetics | Metabolism | Cytonuclear | HALO |
Identification of the SUMO E3 ligase PIAS1 as a potential survival biomarker in breast cancer | Chanda A, Chan A, Deng L, Kornaga EN, Enwere EK, Morris DG, Bonni S | 2017 | PLOS One | Oncology | Classifier, Cytonuclear | HALO |
Spatial distribution of EGFR and KRAS mutation frequencies correlates with histological growth patterns of lung adenocarcinomas | Dietz S, Harms A, Endris V, Eichhorn, Kriegsmann M, Longuespée R, Stenzinger A, Sültmann H, Warth A, and Kazdal D | 2017 | International Journal of Cancer | Oncology | Cytonuclear | HALO |
Aging African green monkeys manifest transcriptional, pathological, and cognitive hallmarks of human Alzheimer's disease | Cramer PE, Gentzel RC, Tanis KQ, Vardigan J, Wang Y, Connolly B, Manfre P, Lodge K, Renger JJ, Zerbinatti C, Uslaner JM | 2017 | Neurobiology of Aging | Neuroscience | Object Colocalization | HALO |
Retinoic-acid-orphan-receptor-C inhibition suppresses Th17 cells and induces thymic aberrations | Guntermann C, Piaia A, Hamel M-L, Theil D, Rubic-Schneider T, del Rio-Espinola A, Dong L, Billich A, Kaupmann K, Dawson J, Hoegenauer K, Orain D, Hintermann S, Stringer R, Pate DD, Doelemeyer A, Deurinck M, and Schümann J | 2017 | JCI Insight | Oncology, Immuno-oncology | Area Quantification, Cytonuclear | HALO |
Digital image analysis agrees with visual estimates of bone marrow trephine biopsy cellularity | Hagiya AS, Etman A, Siddiqi IN, Cen S, Matcuk Jr GR, Brynes RK, Salama ME | 2017 | International Journal of Laboratory Hematology | Oncology | Cytonuclear | HALO |
Selective imaging of internalized proteopathic ?-synuclein seeds in primary neurons reveals mechanistic insight into transmission of synucleinopathies | Karpowicz RJ, Haney CM, Mihaila TS, Sandler RM, Petersson EJ, and Lee VM-Y | 2017 | Journal of Biological Chemistry | Neuroscience | Area Quantification, Cytonuclear | HALO |
Prevalence of somatic mitochondrial mutations and spatial distribution of mitochondria in non-small cell lung cancer | Kazdal D, Harms A, Endris V, Penzel R, Oliveira C, Kriegsmann M, Longuespee R, Winter H, Schneider MA, Muley T, Pfarr N, Weichert W, Stenzinger A,Warth A | 2017 | British Journal of Cancer | Oncology | Cytonuclear | HALO |
Amino Acid Transporter Slc38a5 Controls Glucagon Receptor Inhibition-Induced Pancreatic ? Cell Hyperplasia in Mice | Kim J, Okamoto H, Huang ZJ, Anguiano G, Chen S, Liu Q, Cavino K, Xin Y, Na E, Hamid R, Lee J, Zambrowicz B, Unger R, Murphy AJ, Xu Y, Yancopoulos GD, Li W, Gromada J | 2017 | Cell Metabolism | Metabolism | Cytonuclear | HALO |
APNG as a prognostic marker in patients with glioblastoma | Fosmark S, Hellwege S, Dahlrot RH, Jensen KL, Derand H, Lohse J, Sørensen MD, Hansen S, Kristensen BW | 2017 | PLOS One | Oncology | ISH/FISH | HALO |
TGF? pathway limits dedifferentiation following WNT and MAPK pathway activation to suppress intestinal tumourigenesis | Cammareri P, Vincent DF, Hodder MC, Ridgway RA, Murgia C, Nobis M, Campbell AD, Varga J, Huels DJ, Subramani C, Prescott KLH, Nixon C, Hedley A, Barry ST, Greten FR, Inman GJ, and Sansom OJ | 2017 | Cell Death and Differentiation | Oncology | Layer Thickness | HALO |
Digital analysis and epigenetic regulation of the signature of rejection in colorectal cancer | Koelzer VH, Sokol L, Zahnd S, Christe L, Dawson H, Berger MD, Inderbitzin D, Zlobec I, Lugli A | 2017 | OncoImmunology | Oncology | Cytonuclear | HALO |
Asymmetry of post-mortem neuropathology in behavioural-variant frontotemporal dementia | DJ Irwin, CT McMillan, SX Xie, K Rascovsky, VM Van Deerlin, HB Coslett, R Hamilton, G Aguirre, EB Lee, VMY Lee, JQ Trojanowski, M Grossman | 2017 | Brain | Neuroscience | Area Quantification, Partitions (tiles, margins) | HALO |
Co-clinical Analysis of a Genetically Engineered Mouse Model and Human Prostate Cancer Reveals Significance of NKX3.1 Expression for Response to 5?-reductase Inhibition | Dutta A, Panja S, Virk RK, Kim JY, Zott R, Cremers S, Golombos DM, Liu D, Mosquera JM, Mostaghel EA, Barbieri CE, Mitrofanova A, Abate-Shen C | 2017 | European Urology | Oncology | Area Quantification | HALO |
Amyloid-? plaques enhance Alzheimer's brain tau-seeded pathologies by facilitating neuritic plaque tau aggregation | He Z, Guo JL, McBride JD, Narasimhan S, Kim H, Changolkar L, Zhang B, Gathagan RJ, Yue C, Dengler C, Stieber A, Nitla M, Coulter DA, Abel T, Brunden KR, Trojanowski JQ, Lee V M-Y | 2017 | Nature Medicine | Neuroscience | Area Quantification | HALO |
An ancestral retroviral protein identified as a therapeutic target in type-1 diabetes | Levet S, Medina J, Joanou J, Demolder A, Queruel N, Réant K, Normand M, Seffals M, Dimier J, Germi R, Piofczyk T, Portoukalian J, Touraine J-L, Perron H | 2017 | JCI Insight | Immunology, Metabolism | Classifier, Cytonuclear | HALO |
Receptor tyrosine kinase expression and phosphorylation in canine nasal carcinoma | Hocker SA, Higginbotham ML, Schermerhorn T, Henningson J | 2017 | Research in Veterinary Science | Oncology | Area Quantification, Multiplex IHC | HALO |
Differential roles of RET isoforms in medullary and papillary thyroid carcinomas | Lian EY, Maritan SM, Cockburn JG, Kasaian K, Crupi MJF, Hurlbut D, Jones SJM, Wiseman SM, Mulligan LM | 2017 | Endocrine-Related Cancer | Oncology | Cytonuclear | HALO |
Ante mortem CSF tau levels correlate with post mortem tau pathology in FTLD | Irwin DJ, Lleó A, Xie SX, McMillan CT, Wolk D, Lee EB, Van Deerlin VM, Shaw LM, Trojanowski JQ, Grossman M | 2017 | Annals of Neurology | Neuroscience | Area Quantification | HALO |
Neutorphils dominate the immune cell composition in non-small cell lung cancer | Kargl J, Busch SE, Yang GHY, Kim K-H, Hanke ML, Metz HE, Hubbard JJ, Lee SM, Madtes DK, McIntosh MW, Houghton AM | 2017 | Nature Communications | Oncology | Area Quantification | HALO |
DPP9 enzyme activity controls survival of mouse migratory tongue muscle progenitors and its absence leads to neonatal lethality due to suckling defect | Kim M, Minoux M, Piaia A, Kueng B, Gapp B, Weber D, Haller C, Barbieri S, Namoto K, Lorenz T, Wirsching J, Bassilana F, Dietrich W, Rijli FM, Ksiazek I | 2017 | Developmental Biology | Myology | Classifier, Area Quantification | HALO |
Connexin-43 and aquaporin-4 are markers of ageing-related tau astrogliopathy (ARTAG)-related astroglial response | Kovacs GG, Yousef A, Kaindl S, Lee VM, Trojanowski JQ | 2017 | Neuropathology and Applied Neurobiology | Neuroscience | Area Quantification | HALO |
Angptl4 does not control hyperglucagonemia or ?-cell hyperplasia following glucagon receptor inhibition | Okamoto H, Cavino K, Na E, Krumm E, Kim SY, Stevis PE, Harp J, Murphy AJ, Yancopoulos GD, Gromada J | 2017 | Proceedings of the National Academy of Sciences | Metabolism | Area Quantification | HALO |
Glucagon receptor inhibition normalizes blood glucose in severe insulin-resistant mice | Okamoto H, Kim J, Aglione JP, Lee J, Cavino K, Na E, Rafique A, Kim JH, Harp J, Valenzuela DM, Yancopoulos GD, Murphy AJ, Gromada J | 2017 | Proceedings of the National Academy of Sciences | Metabolism | Area Quantification | HALO |
Cysteinyl leukotriene receptor 1 facilitates tumorigenesis in a mouse model of colitis-associated colon cancer | Osman J, Savari S, Chandrashekar NK, Bellamkonda K, Souglas D, Sjolander A | 2017 | Oncotarget | Oncology, Immunology | Classifier, Area Quantification | HALO |
Plant-based vaccines for oral delivery of type 1 diabetes-related autoantigens: Evaluating oral tolerance mechanisms and disease prevention in NOD mice | Posgai AL, Wasserfall CH, Kwon K-C, Daniell H, Schatz DA, Atkinson MA | 2017 | Scientific Reports | Metabolism | Area Quantification | HALO |
cFOS-SOX9 Axis Reprograms Bone Marrow-Derived Mesenchymal Stem Cells into Chondroblastic Osteosarcoma | He Y, Zhu W, Shin MH, Gary J, Liu C, Dubois W, Hoover SB, Jiang S, Marrogi E, Mock B, Simpson RM, and Huang J | 2017 | Stem Cell Reports | Oncology | Classifier | HALO |
Modulating the therapeutic response of tumours to dietary serine and glycine starvation | Maddocks ODK, Athineos D, Cheung EC, Lee P, Zhang T, van den Broek NJF, Mackay GM, Labuschagne CF, Gay D, Kruiswijk F, Blagih J, Vincent DF, Campbell KJ, Ceteci F, Sansom OJ, Blyth K, Vousden KH | 2017 | Nature | Oncology | Cytonuclear | HALO |
Expression of protein disulfide isomerase family members correlates with tumor progression and patient survival in ovarian cancer | Samanta S, Tamura S, Dubeau L, Mhawech-Fauceglia P, Miyagi Y, Kato H, Lieberman R, Buckanovich RJ, Lin YG, Neamati N | 2017 | Oncotarget | Oncology | Area Quantification | HALO |
Targeting autophagy inhibits melanoma growth by enhancing NK cells infiltration in a CCL5-dependent manner | Mgrditchiana T, Arakeliana T, Paggettia J, Nomana MZ, Virya E, Moussaya E, Van Moera K, Kreisb S, Guerinc C, Buartd S, Roberte C, Borgf C, Vielhg P, Chouaibd S, Berchema G, Janji B | 2017 | Proceedings of the National Academy of Sciences | Oncology, Immuno-oncology | Cytonuclear | HALO |
Weight Pertubation Alters Leptin Signal Transduction in a Region-Specific Manner throughout the Brain | Morabito MV, Ravussin Y, Mueller BR, Skowronski AA, Watanabe K, Foo KS, Lee SX, Lehmann A, Hjorth S, ZeltserLM, LeDuc CA, Leibel RL | 2017 | PLOS One | Metabolism | Cytonuclear | HALO |
A single dose of peripherally infused EGFRvIII-directed CAR T cells mediates antigen loss and induces adaptive resistance in patients with recurrent glioblastoma | ORourke DM, Nasrallah MP, Desai A, Melenhorst JJ, Mansfield K, MorrissetteJJD, Martinez-Lage M, Brem S, Maloney E, Shen A, Isaacs R, Mohan S, Plesa G, Lacey SF, Navenot J-M, Zheng Z, Levine BL, Okada H, June CH, Brogdon JL, Maus MV | 2017 | Science Translational Medicine | Oncology, Immuno-oncology | Cytonuclear, Multiplex IHC | HALO |
The action of ?-hydroxybutyrate on the growth, metabolism and global histone H3 acetylation of spontaneous mouse mammary tumours: evidence of a ?-hydroxybutyrate paradox | Rodrigues LM, Uribe-Lewis S, Madhu B, Honess DJ, Stubbs M, Griffiths JR | 2017 | Cancer & Metabolism | Oncology, Metabolism | Area Quantification, Cytonuclear | HALO |
High levels of tumor-associated neutrophils are associated with improved overall survival in patients with stage II colorectal cancer | RS Berry, M-J Xiong, A Greenbaum, P Mortaji, RA Nofchissey, F Schultz, C Martinez, L Luo, KT Morris, JA Hanson | 2017 | PLOS One | Oncology, Immuno-oncology | Cytonuclear | HALO |
Pathological tau strains from human brains recapitulate the diversity of tauopathies in non-transgenic mouse brain | S Narasimhan, JL Guo, L Changolkar, A Stieber, JD McBride, LV Silva, Z He, B Zhang, RJ Gathagan, JQ Trojanowski, VMY Lee | 2017 | Journal of Neuroscience | Neuroscience | Cytonuclear | HALO |
T-cell Localization, Activation, and Clonal Expansion in Human Pancreatic Ductal Adenocarcinoma | Stromnes IM, Hulbert A, Pierce RH, Greenberg PD, Hingorani SR | 2017 | Cancer Immunology Research | Oncology, Immuno-oncology | Highplex FL | HALO |
Transcriptional mechanisms of resistance to anti-PD-1 therapy | Ascierto ML, Makohon-Moore A, Lipson EJ, Taube JM, McMiller TL, Berger AE, Fan J, Kaunitz GJ, Cottrell TR, Kohutek ZA, Favorov A, Makarov V, Riaz N, Chan TA, Cope L, Hruban RH, Pardoll DM, Taylor BS, Solit DB, Iacobuzio-Donahue CA, Topalian SL | 2017 | Clinical Cancer Research | Oncology, Immuno-oncology | Immune | HALO |
Comparison of branch and distally focused main renal artery denervation using two different radio-frequency systems in a porcine model | Mahfoud F, Pipenhagen CA, Moon LB, Ewen S, Kulenthiran S, Fish JM, Jensen JA, Virmani R, Joner M, Yahagi K, Tsioufis C, Böhm M | 2017 | International Journal of Cardiology | Myology | Layer Thickness | HALO |
Treatment with the WNT5A-mimicking peptide Foxy-5 effictively reduces the metastatic spread of WNT5A-low prostate cancer cells in an orthotopic mouse model | Canesin G, Evans-Axelsson S, Hellsten R, Krzyzanowska A, Prasad CP, Bjartell A, Andersson T | 2017 | PLOS One | Oncology | Membrane | HALO |
Expression of PD-L1 and presence of CD8-positive T cells in pre-treatment specimens of locally advanced cervical cancer | Enwere EK, Kornaga EN, Dean M, Koulis TA, Phan T, Kalantarian M, Köbel M, Ghatage P, Magliocco AM, Lees-Miller DP, Doll CM | 2017 | Modern Pathology | Oncology, Immuno-oncology | Membrane | HALO |
Association of HIV Status With Local Immune Response to Anal Squamous Cell Carcinoma: Implications for Immunotherapy | Yanik EL, Kaunitz GJ, Cottrell TR, Succaria F, McMiller TL, Ascierto ML, Esandrio J, Xu H, Ogurtsova A, Cornish T, Lipson EJ, Topalian SL, Engels EA, Taube JM | 2017 | JAMA Oncology | Oncology, Immuno-oncology | Cytonuclear | HALO |
Chronic Verubecestat Treatment Suppresses Amyloid Accumulation in Advanced Aged Tg2576-A?PPswe Mice Without Inducing Microhemorrhage | Villarreal S, Zhao F, Hyde LA, Holder D, Forest T, Sondey M, Chen X, Sur C, Parker EM, Kennedy ME | 2017 | Journal of Alzheime's Disease | Neuroscience | Object Colocalization | HALO |
In vivo characterization of a new type of biodegradable starch microsphere for transarterial embolization | Sommer CM, Do TD, Schlett CL, Flechsig P, Gockner TL, Kuthning A, Vollherbst DF, Pereira PL, Kauczor HU, Macher-Göppinger S | 2017 | Journal of Biomaterials Applications | Oncology | Classifier | HALO |
A randomized, open-label study of the efficacy and safety of AZD4547 monotherapy versus paclitaxel for the treatment of advanced gastric adenocarcinoma with FGFR2 polysomy or gene amplification | Van Cutsem E, Bang Y-J, Mansoor W, Petty RD, Chao Y, Cunningham D, Ferry DR, N. R. Smith NR, Frewer P, Ratnayake J, Stockman PK, Kilgour E, and Landers D | 2017 | Annals of Oncology | Oncology | Classifier, ISH/FISH | HALO |
Persistence of Pancreatic Insulin mRNA Expression and Proinsulin Protein in Type 1 Diabetes Pancreata | Wasserfall C, Nick HS, Campbell-Thompson M, Beachy D, Haataja L, Kusmartseva I, Posgai A, Beery M, Rhodes C, Bonifacio E, Arvan P, Atkinson M | 2017 | Cell Metabolism | Metabolism | Area Quantification | HALO |
Neuron loss and degeneration in the progression of TDP-43 in frontotemporal lobar degeneration | Yousef A, Robinson JL, Irwin DJ, Byrne MD, Kwong LK, Lee EB, Xu Y, Xie SX, Rennert L, Suh ER, Van Deerlin VM, Grossman M, Lee VM-Y, Trojanowski JQ | 2017 | Acta Neuropathologica Communications | Area Quantification, Cytonuclear | HALO | |
Qualitative Comparison Between Carrier-based and Classical Tissue Microarrays | Lisenko K, Leichsenring J, Zgorzelski C, Longuespee R, Casadonte R, Harms A, Kazdal D, Stenzinger A, Warth A, Kriegsmann M | 2017 | Applied Immunohistochemistry & Molecular Morpholgy | HALO | ||
In situ macrophage phenotypic transition is affected by altered cellular composition prior to acute sterile muscle injury | Patsalos A, Pap A, Varga T, Trencsenyi G, Contreras GA, Garai I, Papp Z, Dezso B, Pintye E, Nagy L | 2017 | The Journal of Physiology | Myology | HALO | |
Obstruction of BRAFV600E transcription by complementary PNA oligomers as a means to inhibit BRAF-mutant melanoma growth | Rothman JH, Surriga O, de Stanchina E, Vasudeva SD, Schwartz GK | 2017 | Cancer Gene Therapy | Oncology | HALO | |
The integrative clinical impact of tumor-infiltrating T lymphocytes and NK cells in relation to B lymphocyte and plasma cell density in esophageal and gastric adenocarcinoma | Svensson MC, Warfvinge CF, Fristedt R, Hedner C, Borg D, Eberhard J, Micke P, Nodin B, Leandersson K, Jirstrom K | 2017 | Oncotarget | Immuno-oncology | Object Colocalization | HALO |
Control of mitochondrial function and cell growth by the atypical cadherin Fat1 | Cao LL, Riascos-Bernal DF, Chinnasamy P, Dunaway CM, Hou R, Pujato MA, O'Rourke BP, Miskolci V, Guo L, Hodgson L, Fiser A, Sibinga NES | 2016 | Nature | Metabolism | Cytonuclear | HALO |
Phosphorylation of calcium/calmodulin-stimulated protein kinase II at T286 enhances invasion and migration of human breast cancer cells | Chi M, Evans, Gilchrist J, Mayhew J, Hoffman A, Pearsall EA, Jankowski H, Brzozowski JS, Skelding KA | 2016 | Scientific Reports | Oncology | Cytonuclear | HALO |
Evidence of ?-Cell Dedifferentiation in Human Type 2 Diabetes | Cinti F, Bouchi R, Kim-Muller JY, Ohmura Y, Sandoval PR, Masini M, Marselli L, Suleiman M, Ratner LE, Marchetti P, Accili D | 2016 | The Journal of Clinical Endocrinology & Metabolism | Metabolism | Cytonuclear | HALO |
Cutaneous wound healing through paradoxical MAPK activation by BRAF inhibitors | Escuin-Ordinas H, Li S, Xie MW, Sun L, Hugo W, Huang RR, Jiao J, Meira de-Faria F, Realegeno S, Krystofinski P, Azhdam A, Komenan SMD, Atefi M, Comin-Anduix B, Pellegrini M, Cochran AJ, Modlin RL, HerschmanHR, Lo RS, McBride WH, Segura T, Ribas A | 2016 | Nature Communications | Wound Healing | Cytonuclear | HALO |
A Phase II Trial of Dovitinib in BCD-Unresponsive Urothelial Carcinoma with FGFR3 Mutations or Over-Expression: Hoosier Cancer Research Network Trial HCRN 12-157 | Hahn NH, Bivalacqua TJ, Ross AE, Netto GJ, Baras AS, Park JC, Chapman C, Masterson TA, Koch MO, Bihrle R, Foster RS, Gardner TA, Cheng L, Jones DR, Kyle McElyea K, Sandusky GE, Breen T, Liu Z, Albany C, Moore ML, Loman RA, Reed A, Turner SA, de Abreu FB, Gallagher TL, Tsongalis GJ, Plimack ER, Greenberg RE, Geynisman DM | 2016 | Clinical Cancer Research | Oncology | Classifier, Cytonuclear | HALO |
Mitogen-activated Protein Kinase Kinase Activity Maintains Acinar-to-Ductal Metaplasia and Is Required for Organ Regeneration in Pancreatitis | Halbrook CJ, Wen H-J, Ruggeri JM, Takuchi KK, Zhang Y, di Magliano MP, Crawford HC | 2016 | Cellular and Molecular Gastroenterology and Hepatology | Immunology, Gastroenterology | Cytonuclear | HALO |
Fully automated RNAscope in situ hybridization assays for formalin?fixed paraffin?embedded cells and tissues | Anderson CM, Zhang B, Miller M, Butko E, Wu X, Laver T, Kernag C, Kim J, Luo Y, Lamparski H | 2016 | Journal of Cellular Biochemistry | Oncology, Gastroenterology, Infectious Disease | ISH/FISH | HALO |
A Depot Medroxyprogesterone Acetate Dose That Modes Human Use and Its Effect on Vaginal SHIV Acquisition Risk | Butler K, Ritter JM, Ellis S, Morris MR, Hanson DL, McNicholl JM, Kersh EN | 2016 | J Acquir Immune Defic Syndr | Infectious Disease | Layer Thickness | HALO |
Epigenetic regulation of the thioredoxin-interacting protein (TXNIP) gene by hyperglycemia in kidney | De Marinis Y, Cai M, Bompada P, Atac D, Kotova O, Johansson ME, Garcia-Vaz E, Gomez MF, Laakso M, Groop L | 2016 | Kidney International | Metabolism | Area Quantification | HALO |
ProNGF is a potential diagnostic biomarker for thyroid cancer | Faulkner S, Roselli S, Demont Y, Pundavela J, Choquet G, Leissner P, Oldmeadow C, Attia J, Walker MM, Hondermarck H | 2016 | Oncotarget | Oncology | Area Quantification | HALO |
The Dynamics and Turnover of Tau Aggregates in Cultured Cells: Insights into Therapies for Tauopathies | Guo JL, Buist A, Soares A, Callaerts K, Calafate S, Stevenaert F, Daniels JP, Zoll BE, Crowe A, Brunden KR, Moechars D, Lee VMY | 2016 | The Journal of Biological Chemistry | Neuroscience | Area Quantification | HALO |
Unique pathological tau conformers from Alzheimer's brains transmit tau pathology in nontransgenic mice | Guo JL, Narasimhan S, Changolkar L, He Z, Stieber Z, Zhang B, Gathagan RJ, Iba M, McBride JD, Trojanowski JQ, Lee VMY | 2016 | Journal of Experimental Medicine | Neuroscience | Area Quantification | HALO |
Bimodality of intratumor Ki67 expression is an independent prognostic factor of overall survival in patients with invasive breast carcinoma | Laurinavicius A, Plancoulaine B, Rasmusson A, Besusparis J, Augulis R, Meskauskas R, Herlin P, Laurinaviciene A, Muftah AAA, Miligy I, Aleskandarany M, Rakha EA, Green AR, Ellis IO | 2016 | Virchows Archiv | Oncology | Classifier, Cytonuclear | HALO |
Resistance to Anti-VEGF Therapy Mediated by Autocrine IL6/STAT3 Signaling and Overcome by IL6 Blockade | Eichten A, Su J, Adler AP, Zhang L, Ioffe E, Parveen AA, Yancopoulos GD, Rudge J, Lowy I, Lin HC, MacDonald D, Daly C, Duan X, Thurston G | 2016 | Cancer Research | Oncology, Immuno-oncology | Cytonuclear, Object Colocalization | HALO |
Cerebral Protection During MitraClip Implantation: Initial Experience at 2 Centers | Frerker C, Schlüter M, Sanchez OD, Reith S, Romero ME, Ladich E, Schröder J, Schmidt T, Kreidel F, Joner M | 2016 | JACC: Cardiovascular Interventions | Myology | Object Colocalization | HALO |
Upregulation of Glucose-Regulated Protein 78 in Metastatic Cancer Cells Is Necessary for Lung Metastasis Progression | Lizardo MM, Morrow JJ, Miller TE, Hong ES, Ren L, Mendoza A, Halsey CH, Scacheri PC, Helman LJ, Khanna C | 2016 | Neoplasia | Oncology | Cytonuclear | HALO |
Evaluation of the brain-penetrant microtubule-stabilizing agent, dictyostatin, in the PS19 tau transgenic mouse model of tauopathy | Makani V, Zhang B, Han H, Yao Y, Lassalas P, Lou K, Paterson I, Lee VMY, Trojanowski JQ, Ballatore C, Smith AB, Brunden KR | 2016 | Acta Neuropatholgica Communications | Neuroscience | Area Quantification | HALO |
CNS-accessible inhibitor of glucosylceramide synthase for substrate reduction therapy of neuronopathic Gaucher disease | Marshall J, Sun Y, Bangari DS, Budman E, Park H, Nietupski JB, Allaire A, Cromwell MA, Wang B, Grabowski GA, Leonard JP, Cheng SH | 2016 | Molecular Therapy | Neuroscience | Area Quantification | HALO |
Leptin, BMI, and a Metabolic Gene Expression Signature Associated with Clinical Outcome to VEGF Inhibition in Colorectal Cancer | Pommier AJC, Farren M, Patel B, Wappett M, Michopoulos F, Smith NR, Kendrew J, Frith J, Huby R, Eberlein C, Campbell H, Womack C, Smith PD, Robertson J, Morgan S, Critchlow SE, Barry ST | 2016 | Cell Metabolism | Oncology, Metabolism, Gastroenterology | Area Quantification | HALO |
Intrathecal Administration of AAV/GALC Vectors in 10- 11-Day-Old Twitcher Mice Improves Survival and Is Enhanced by Bone Marrow Transplant | Karmuthil-Melethil S, Marshall MS, Heindel C, Jakubauskas B, Bongarzone ER, Gray SJ | 2016 | Journal of Neuroscience Research | Neuroscience | Axon | HALO |
Tasquinimod modulates tumor-infiltrating myeloid cells and improves the antitumor immune response to PD-L1 blockade in bladder cancer | Nakhlé J, Pierron V, Bauchet A-L, Plas P, Thiongane A, Meyer-Losic F, Schmidlin F | 2016 | OncoImmunology | Oncology, Immuno-oncology | Cytonuclear | HALO |
Primary resistance to PD-1 blockade mediated by JAK1/2 mutations | Shin DS, Zaretsky JM, Escuin-Ordinas H, Garcia-Diaz A, Hu-Lieskovan S, Kalbasi A, Grasso CS, Hugo W, Sandoval S, Torrejon DY, Palaskas N, Rodriguez GA, Parisi G, Azhdam A, Chmielowski B, Cherry G, Seja E, Berent-Maoz B, Shintaku IP, Le DT, Pardol DM, Diaz LA, Tumeh PC, Graeber TG, Lo RS, Comin-Anduix B, Ribas A | 2016 | Cancer Discovery | Oncology, Immuno-oncology | Cytonuclear | HALO |
KS-Detect-Validation of Solar Thermal PCR for the Diagnosis of Kaposi's Sarcoma Using Pseudo-Biopsy Samples | Snodgrass R, Gardner A, Jiang L, Fu C, Cesarman E, Erickson D | 2016 | PLOS ONE | Oncology | Cytonuclear | HALO |
Development of antibody-siRNA conjugate targeted to cardiac and skeletal muscles | Sugo T, Terada M, Oikawa T, Miyata K, Nishimura S, Kenjo E, Ogasawara-Shimizu M, Makita Y, Imaichi S, Murata S, Kentaro Otaka, Kikuchi K, Teratani M, Masuda Y, Kamei T, Takagahara S, Ikeda S, Ohtaki T, Matsumoto H | 2016 | The Journal of Controlled Release | Myology | Cytonuclear, Muscle Fiber | HALO |
Use of the Fluidigm C1 platform for RNA sequencing of single mouse pancreatic islet cells | Xin Y, Kim J, Ni M, Wei Y, Okamoto H, Lee J, Adler C, Cavino K, Murphy AJ, Yancopoulos GD, Lin HC, Gromada J | 2016 | Proceedings of the National Academy of Sciences | Metabolism | Cytonuclear | HALO |
Comparison of the methods for measuring the Ki-67 labeling index in adrenocortical carcinoma: manual versus digital image analysis | Yamazaki Y, Nakamura Y, Shibahara Y, Konosu-Fukaya S, Sato N, Kubota-Nakayama F, Oki Y, Baba S, Midorikawa S, Morimoto R, Satoh F, Sasano | 2016 | Human Pathology | Oncology | Cytonuclear | HALO |
Variability in Platelet-Derived Growth Factor Receptor Alpha Antibody Specificity May Impact Clinical Utility of Immunohistochemistry Assays | Holzer TR, Reising LO, Credille KM, Schade AE, Oakley | 2016 | Journal of Histochemistry & Cytochemistry | Oncology | Cytonuclear, ISH/FISH | HALO |
Differential Cytokine Gene Expression in Granulomas from Lungs and Lymph Nodes of Cattle Experimentally Infected with Aerosolized Mycobacterium bovis | Palmer MV, Thacker TC, Waters WR | 2016 | PLOS One | Infectious Disease | ISH/FISH | HALO |
RNA Sequencing of Single Human Islet Cells Reveals Type 2 Diabetes Genes | Xin Y, Kim J, Okamoto H, Ni M, Wei Y, Adler C, Murphy AJ, Yancopoulos GD, Lin C, Gromada J | 2016 | Endocrinology | Metabolism | Islet | HALO |
The Prognostic Impact of NK/NKT Cell Density in Periampullary Adenocarcinoma Differs by Morphological Type and Adjuvant Treatment | Lundgren S, Warfvinge CF, Elebro J, Heby M, Nodin B, Krzyzanowska A, Bjartell A, Leandersson K, Eberhard J, Jirstrom K | 2016 | PLOS ONE | Oncology, Immuno-oncology | Object Colocalization | HALO |
Solid-state NMR structure of a pathogenic fibril of full-length human [alpha]-synuclein | Tuttle MD, Comellas G, Nieuwkoop AJ, Covell DJ, Berthold DA, Kloepper KD, Courtney JM, Kim JK, Barclay AM, Kendall A, Wan W, Stubbs G, Schwieters CD, Lee VMY, George JM, Rienstra CM | 2016 | Structural & Molecular Biology | Neuroscience | Area Quantification | HALO |
RNA Sequencing of Single Human Islet Cells Reveals Type 2 Diabetes Genes | Xin Y, Kim J, Okamoto H, Ni M, Wei Y, Adler C, Murphy AJ, Yancopoulos GD, Lin C, Gromada J | 2016 | Cell Metabolism | Metabolism | ISH/FISH | HALO |
Synergistic targeted inhibition of MEK and dual PI3K/mTOR diminishes viability and inhibits tumor growth of canine melanoma underscoring its utility as a preclinical model for human mucosal melanoma | Wei B-R, Michael HT, Hasley CHC, Peer CJ, Adhikari A, Dwyer JE, Hoover SB, El Meskini R, Kozlov S, Ohler ZW, Figg WD, Merlino G, Simpson RM | 2016 | Pigment Cell & Melanoma Research | Oncology | Area Quantification | HALO |
Mutations Associated with Acquired Resistance to PD-1 Blockade in Melanoma | Zaretsky JM, Garcia-Diaz A, Shin DS, Escuin-Ordinas H, Hugo W, Hu-Lieskovan S, Torrejon DY, Abril-Rodriguez G, Sandoval S, Barthly L, Saco J, Homet Moreno BH, Mezzadra R, Chmielowski B, Ruchalski K, Shintaku IP, Sanchez PJ, Puig-Saus C, Cherry G, Seja E, Kong X, Pang J, Berent-Maoz B, Comin-Anduix B, Graeber TG, Tumeh PC, Schumacher TNM, Lo RS, Ribas A | 2016 | The New England Journal of Medicine | Oncology, Immuno-oncology | Cytonuclear | HALO |
The PDE10A inhibitor MP-10 and haloperidol produce distinct gene expression profiles in the striatum and influence cataleptic behavior in rodents | Gentzel RC, Toolan D, Roberts R, Koser AJ, Kandebo M, Hershey J, Renger JJ, Uslaner J, Smith SM | 2015 | Neuropharmacology | Neuroscience | Cytonuclear | HALO |
Phenotyping of tumor-associated macrophages in colorectal cancer: impact on single cell invasion (tumor budding) and clinicopathological outcome | Koelzer VH, Canonica K, Dawson H, Sokol L, Karamitopoulou-Diamantis E, Lugli A, Zlobec I | 2015 | OncoImmunology | Oncology, Immuno-oncology, Gastroenterology | Cytonuclear | HALO |
G-protein-independent coupling of MC4R to Kir7. 1 in hypothalamic neurons | Ghamari-Langroudi M, Digby GJ, Sebag JA, Millhauser GL, Palomino R, Matthews R, Gillyard T, Panaro BL, Tough IR, Cox HM, Denton JS, Cone RD | 2015 | Nature | Metabolism | ISH/FISH | HALO |
Analysis of putative mucosal SHIV susceptibility factors during repeated DMPA treatments in pigtail macaques | Butler K, Ritter J, Ellis S, Henning TR, Montague J, Zaki S, Garber, McNicholl JM, Kersh EN | 2015 | Journal of medical primatology | Infectious Disease | Layer Thickness | HALO |
Semi-Automated Digital Image Analysis of Pick's Disease and TDP-3 Proteinopathy | Irwin DJ, Byrne MD, McMillan CT, Cooper F, Arnold SE, Lee EB, Van Deerlin VM, Xie SX, Lee VM, Grossman M, Trojanowski JQ | 2015 | Journal of Histochemistry & Cytochemistry | Neuroscience | Object Colocalization, Layer Thickness | HALO |
Myostatin blockade with a fully human monoclonal antibody induces muscle hypertrophy and reverses muscle atrophy in young and aged mice | Latres E, Pangilinan J, Miloscio L, Bauerlein R, Na E, Potocky TB, Huang Y, Eckersdorff M, Rafique A, Mastaitis J, Lin C, Murphy AJ, Yancopoulos GD, Gromada J, Stitt T | 2015 | Skeletal Muscle | Myology | Muscle Fiber | HALO |
Relationship of Estimated SHIV Acquisition Time Points During the Menstrual Cycle and Thinning of Vaginal Epithelial Layers in Pigtail Macaques | Kersh EN, Ritter J, Butler K, Ostergaard SD, Hanson D, Ellis S, Zaki S, McNicholl JM | 2015 | Sexually Transmitted Diseases | Infectious Disease | Layer Thickness | HALO |
Glucagon Receptor Blockade With a Human Antibody Normalizes Blood Glucose in Diabetic Mice and Monkeys | Okamoto H, Cavino K, Na E, Krumm E, Kim SY, Cheng X, Murphy AJ, Yancopoulos GD, Gromada J | 2015 | Endocrinology | Metabolism | Area Quantification | HALO |
Nerve fibers infiltrate the tumor microenvironment and are associated with nerve growth factor production and lymph node invasion in breast cancer | Pundavela J, Roselli S, Faulkner S, Attia J, Scott RJ, Thorne RF, Forbes JF, Bradshaw RA, Walker MM, Jobling P, Hondermarck H | 2015 | Molecular Oncology | Oncology, Neuroscience | Area Quantification | HALO |
Tasquinimod triggers an early change in the polarization of tumor associated macrophages in the tumor microenvironment | Olsson A, Nakhle J, Sundstedt A, Plas P, Bauchet AL, Pierron V, Bruetschy L, Deronic A, Tomgren M, Liberg D, Schmidlin F, Leanderson T | 2015 | Journal for ImmunoTherapy of Cancer | Oncology, Immuno-oncology | Cytonuclear | HALO |
Exacerbated experimental colitis in TNFAIP8-deficient mice | Sun H, Lou Y, Porturas T, Morrissey S, Luo G, Qi J, Ruan Q, Shi S, Chen YH | 2015 | The Journal of Immunology | Gastroenterology | Cytonuclear | HALO |
Combination therapy reverses hyperglycemia in NOD mice with established type 1 diabetes | Xue S, Posgai A, Wasserfall C, Myhr C, Campbell-Thompson M, Mathews CE, Brusko T, Rabinovitch A, Savinov A, Battaglia M, Schatz D, Haller M, Atkinson MA | 2015 | Diabetes | Metabolism | Cytonuclear | HALO |
A combined oral contraceptive affects mucosal SHIV susceptibility factors in a pigtail macaque (Macaca nemestrina) model | Ostergaard DS, Butler K, Ritter JM, Johnson R, Sanders J, Powell N, Lathrop G, Zaki SR, McNicholl JM, Kersh EN | 2015 | Journal of medical primatology | Infectious Disease | Layer Thickness | HALO |
Applicability of digital analysis and imaging technology in neuropathology assessment | Dunn WD, Gearing M, Park Y, Zhang L, Hanfelt J, Glass JD, Gutman DA | 2015 | Neuropathology | HALO | ||
Islet-1 is essential for pancreatic ?-cell function | Ediger BN, Du A, Liu J, Hunter CS, Walp ER, Schug J, Kaestner KH, Stein R, Stoffers DA, May CL | 2014 | Diabetes | Metabolism | Cytonuclear | HALO |
Characterization of the exocrine pancreas in the male Zucker diabetic fatty rat model of type 2 diabetes mellitus following 3 months of treatment with sitagliptin | Forest T, Holder D, Smith A, Cunningham C, Yao X, Dey M, Frederick C, Prahalada S | 2014 | Endocrinology | Metabolism | Cytonuclear | HALO |
Peripheral androgen receptor gene suppression rescues disease in mouse models of spinal and bulbar muscular atrophy | Lieberman AP, Yu Z, Murray S, Peralta R, Low A, Guo S, Yu XX, Cortes CJ, Bennett CF, Monia BP, La Spada AR, Hung G | 2014 | Cell Reports | Myology | Muscle Fiber | HALO |
ANGPTL8/betatrophin does not control pancreatic beta cell expansion | Gusarova V, Alexa CA, Na E, Stevis PE, Xin Y, Bonner-Weir S, Cohen JC, Hobbs HH, Murphy AJ, Yancopoulos GD, Gromada J | 2014 | Cell | Metabolism | Area Quantification | HALO |
PD-1 blockade induces responses by inhibiting adaptive immune resistance | Tumeh PC, Harview CL, Yearley JH, Shintaku IP, Taylor EJM, Robert L, Chmielowski B, Spasic M, Henry G, Ciobanu V, West AN, Carmona M, Kivork C, Seja E, Cherry G, Gutierrez A, Grogan TR, Mateus C, Tomasic G, Glaspy JA, Emerson RO, Robins H, Pierce RH, Elas | 2014 | Nature | Oncology, Immuno-oncology | Cytonuclear | HALO |
Marked expansion of exocrine and endocrine pancreas with incretin therapy in humans with increased exocrine pancreas dysplasia and potential for glucagon-producing neuroendocrine tumors | Butler AE, Campbell-Thompson M, Gurlo T, Dawson DW, Atkinson M, Butler PC | 2013 | Diabetes | Oncology, Metabolism | Cytonuclear | HALO |
CRISPR-Cas9 gene editing of hepatitis B virusin chronically infected humanized mice | Stone D, Long KR, Loprieno MA, De Silva Feelixge HS, Kenkel EJ, Liley, RM, Rapp S, Roychoudhury P, Nguyen T, Stensland L, Cólon-Thillet R, Klouser LM, Weber ND, Le C, Wagoner J, Goecker EA, Li AZ, Eichholz K, Corey L, Tyrrell DL, Greninger AL, Huang ML, Polyak SJ, Aubert M, Sagartz JE, Jerome KR | 2021 | Molecular Therapy Methods & Clinical Development | Infectious Disease | HALO Link | |
Digital Immunophenotyping Predicts Disease Free and Overall Survival in Early Stage Melanoma Patients | De Logu F, Galli F, Nassini R, Ugolini F, Simi S, Cossa M, Miracco C, Gianatti A, De Giorgi V, Rulli E, Cossu A, Massi D, Mandalà M | 2021 | Cells | Oncology, Immuno-oncology | Multiplex IHC | HALO, HALO Link |
Monomeric/dimeric forms of Fgf15/FGF19 show differential activity in hepatocyte proliferation and metabolic function | Williams CM, Calderon JH, Hock E, Jimenez Y, Barringer K, Carbonaro M, Molina-Portela MP, Thurston G, Li Z, Daly C | 2021 | The FASEB Journal | Metabolism | Cytonuclear | HALO, HALO Link |
CD38 in Advanced Prostate Cancers | Guo C, Crespo M, Gurel B, Dolling D, Rekowski J, Sharp A, Petremolo A, Sumanasuriya S, Rodrigues DN, Ferreira A, Pereira R, Figueiredo I, Mehra N, Lambros MBK, Neeb A, Gil V, Seed G, Terstappen L, Alimonti A, Drake CG, Yuan W, de Bono JS | 2021 | European Urology | Oncology | Classifier, Highplex FL | HALO |
Exploring transcriptional regulators Ref-1 and STAT3 as therapeutic targets in malignant peripheral nerve sheath tumours | Gampala S, Shah F, Zhang C, Rhodes SD, Babb O, Grimard M, Wireman RS, Rad E, Calver B, Bai R-Y, Staedtke V, Hulsey EL, Saadatzadeh MR, Pollok KE, Tong Y, Smith AE, Clapp DW, Tee AR, Kelley MR, Fishel ML | 2021 | British Journal of Cancer | Oncology | Area Quantification, Cytonuclear | HALO |
First in class dual MDM2/MDMX inhibitor ALRN-6924 enhances antitumor efficacy of chemotherapy in TP53 wild-type hormone receptor-positive breast cancer models | Pairawan S, Zhao M, Yuca E, Annis A, Evans K, Sutton D, Carvajal L, Ren J-G, Santiago S, Guerlavais, Akcakanat A, Tapia C, Yang F, Bose PSC, Zheng X, Dumbrava EI, Aivado M, Meric-Bernstam F | 2021 | Breast Cancer Research | Oncology | Cytonuclear | HALO |
Influence of tumor-infiltrating immune cells on local control rate, distant metastasis, and survival in patients with soft tissue sarcoma | Smolle MA, Herbsthofer L, Goda M, Granegger B, Brcic I, Bergovec M, Scheipl S, Prietl B, El-Heliebi A, Pichler M, Gerger A, Posch F, Tomberger M, López-García P, Feichtinger J, Baumgartner C, Leithner A, Liegl-Atzwanger B, Szkandera J | 2021 | OncoImmunology | Immuno-oncology | Highplex FL | HALO |
Phenotypic characterization of Adig null mice suggests roles for adipogenin in the regulation of fat mass accrual and leptin secretion | Alvarez-Guaita A, Patel S, Lim K, Haider A, Dong L, Conway OJ, Ma MKL, Chiarugi D, Saudek V, O'Rahilly S, Savage DB | 2021 | Cell Reports | Metabolism | Vacuole | HALO |
Prognostic Impact of CXCR7 and CXCL12 Expression in Patients with Esophageal Adenocarcinoma | Goto M, Shibahara Y, Baciu C, Allison F, Yeung JC, Darling GE, Liu M | 2021 | Thoracic Oncology | Oncology | HALO | |
An extended release GLP-1 analogue increases ?-synuclein accumulation in a mouse model of prodromal Parkinson's disease | Bergkvist L, Johnson ME, Mercado G, Steiner JA, Meyerdick L, Schulz E, Madaj Z, Ma J, Becker K, Li Y, Brudin P | 2021 | Experimental Neurology | Neuroscience | Area Quantification | HALO |
Activation of the renal GLP?1R leads to expression of Ren1 in the renal vascular tree | Bjørnholm KD, Ougaard ME, Skovsted GF, Knudsen LB, Pyke C | 2021 | Endocrinology, Diabetes, & Metabolism | Metabolism | ISH/FISH | HALO |
A Method to Pre-Screen Rat Mammary Gland Whole-Mounts Prior To RNAscope | Duderstadt EL, Sanders MA, Samuelson DJ | 2021 | Journal of Mammary Gland Biology and Neoplasia | ISH/FISH | HALO | |
Activated Regulatory T-Cells, Dysfunctional and SenescentT-Cells Hinder the Immunity in Pancreatic Cancer | Sivakumar S, Abu-Shah E, Ahern DJ, Arbe-Barnes EH, Jainarayanan AK, Mangal N, Reddy S, Rendek A, Easton A, Kurz E, Silva M, Soonawalla Z, Heij LR, Bashford-Rogers R, Middleton MR, DUstin ML | 2021 | cancers | Classifier, Multiplex IHC, Spatial Analysis, Highplex FL | HALO | |
Age-associated expression of p21and p53 during human wound healing | Chia CW, Sherman-Baust CA, Larson SA, Pandey R, Withers R, Karikkineth AC, Zukley LM, Campisi J, Egan JM, Sen R, Ferrucci L | 2021 | Aging Cell | Dermatology | Area Quantification, ISH/FISH, Multiplex IHC | HALO |
Breast adipocyte size associates with ipsilateral invasive breast cancer risk after ductal carcinoma in situ | Almekinders MMM, Schaapveld M, Thijssen B, Visser LL, Bismeijer T, Sanders J, Isnaldi E, Hofland I, Mertz M, Wessels LFA, Broeks A, Hooijberg E, Zwart W, Lips EH, Grand Challenge PRECISION Consortium, Desmedt C, Wesseling J | 2021 | npj Breast Cancer | Oncology | Vacuole | HALO |
COM902, a novel therapeutic antibody targeting TIGIT augments anti-tumor T cell function in combination with PVRIG or PD-1 pathway blockade | Kyle Hansen K, Sandeep Kumar, Kathryn Logronio, Sarah Whelan, Samir Qurashi, Hsin-Yuan Cheng, Andrew Drake, Margaret Tang, Patrick Wall, David Bernados, Ling Leung, Eran Ophir, Zoya Alteber Z, Gady Cojocaru G, Moran Galperin M, Masha Frenkel M, Mark White M, John Hunter J, Spencer C. Liang & Maya F. Kotturi | 2021 | Cancer Immunology, Immunotherapy | Immuno-oncology | HALO | |
Conventional and semi-automatic histopathological analysis of tumor cell content for multigene sequencing of lung adenocarcinoma | Kazdal D, Rempel E, Oliveira C, Allgäuer M, Harms A, Singer K, Kohlwes E, Ormanns S, Fink L, Kriegsmann J, Leichsenring M, Kriegsmann K, Stögbauer F, Tavernar L, Leichsenring J, Volckmar A-L, Longuespée R, Winter H, Eichhorn M, Heußel CP, Herth F, Christopoulos P, Reck M, Muley T, Weichert W, Budczies J, Thomas M, Peters S, Warth A, Schirmacher P, Stenzinger A, Kriegsmann M | 2021 | Translational Lung Cancer Research | Oncology | Classifier, Cytonuclear | HALO |
Crotonaldehyde exposure induces liver dysfunction and mitochondrial energy metabolism disorder in rats | Zhang S, Zhang B, Zhang Q, Zhang Z | 2021 | Toxicology Mechanisms and Methods | Metabolism | HALO | |
Cytotoxic lymphocytes target characteristic biophysical vulnerabilities in cancer | Bhanot U, MOrris L, Boire A, Hsu KC, Massague J, Huse M, Er EE | 2021 | Immunity | Immuno-oncology | HALO | |
Empagliflozin Disrupts a Tnfrsf12a-Mediated Feed Forward Loop That Promotes Left Ventricular Hypertrophy | Yerra VG, Batchu SN, Kabir G, Advani SL, Liu Y, Siddiqi FS, Connelly KA, Advani A | 2021 | Cardiovascular Drugs and Therapy | Myology | HALO | |
Genetic Inactivation of Peroxiredoxin-I Impairs the Growth of Human Pancreatic Cancer Cells | Dahou H, Minati M-A, Jacquemin P, Assi M | 2021 | antioxidants | Oncology | Cytonuclear | HALO |
Immune-regulated IDO1-dependent tryptophan metabolism is source of one-carbon units for pancreatic cancer and stellate cells | Newman AC, Falcone M, Uribe AH, Zhang T, Athineos D, Pietzke M, Vazquez A, Blyth K, Maddocks ODK | 2021 | Molecular Cell | Immuno-oncology | Classifier, ISH/FISH | HALO |
Inhibition of STAT3 augments antitumor efficacy of anti-CTLA-4 treatment against prostate cancer | Witt K, Evans-Axelsson S, Lundqvist A, Johansson M, Bjartell A, Hellsten R | 2021 | Cancer Immunology, Immunotherapy | Immuno-oncology | Area Quantification, Multiplex IHC | HALO |
The immune suppressive microenvironment affects efficacy of radio-immunotherapy in brain metastasis | Niesel K, Schulz M, Anthes J, Alekseeva T, Macas J, Salamero-Boix A, Mockl A, Oberwahrenbrock T, Lolies M, Stein S, Plate KH, Reiss Y, Rodel F, Sevenich L | 2021 | EMBO Molecular Medicine | Immuno-oncology | Spatial Analysis, Highplex FL | HALO |
Tracing Lung Cancer Risk Factors Through Mutational Signatures in Never-Smokers | Landi MT, Synnott NC, Rosenbaum J, Zhang T, Zhu B, Shi J, Zhao W, Kebede M, Sang J, Choi J, Mendoza L, Pacheco M, Hicks B, Caporaso NE, Abubakar M, Gordenin DA, Wedge, Alexandrov LB, Rothman N, Lan Q, Garcia-Closas M, Chanock SJ | 2021 | American Journal of Epidemiology | Oncology | HALO | |
Tumor cell PD-L1 expression is a strong predictor of unfavorable prognosis in immune checkpoint therapy-naive clear cell renal cell cancer | Möller K, Fraune C, Blessin NC, Lennartz M, Kluth M, Hube-Magg C, Lindhorst L, Dahlem R, Fisch M, Eichenauer T, Riechardt S, Simon R, Sauter G, Büscheck F, Höppner W, Matthies C, Doh O, Krech T, Marx AH, Zecha H, Rink M, Steurer S, Clauditz TS | 2021 | International Urology and Nephrology | Immuno-oncology | Multiplex IHC, TMA | HALO |
Validation of multiplex immunofluorescence and digital image analysis for programmed death-ligand 1 expression and immune cell assessment in non-small cell lung cancer: comparison with conventional immunohistochemistry | Wu J, Mao L, Sun W, Yang X, Wang H, Liu X, Chi K, Xiaozheng H, Lin D | 2021 | Journal of Clinical Pathology | Immuno-oncology | HALO | |
VGLUT2 is a determinant of dopamine neuron resilience in a rotenone model of dopamine neurodegeneration | Buck SA, De Miranda BR, Logan RW, Fish KN, Greenamyre JT, Freyberg Z | 2021 | The Journal of Neuroscience | Neuroscience | ISH/FISH | HALO |
Ki-67 Proliferation Index Assessment in Gastroenteropancreatic Neuroendocrine Tumors by Digital Image Analysis With Stringent Case and Hotspot Level Concordance Requirements | Boukhar SA, Gosse MD, Bellizzi AM, Rajan A | 2021 | American Journal of Clinical Pathology | Oncology | HALO | |
Global Neurotoxicity: Quantitative Analysis of Rat Brain Toxicity Following Exposure to Trimethyltin | Srivastava A, Liachenko S, Sarkar S, Paule M, Sadovova N, Hanig JP | 2021 | International Journal of Toxicology | Toxicology | HALO | |
High estrogen receptor alpha activation confers resistance to estrogen deprivation and is required for therapeutic response to estrogen in breast cancer | Traphagen NA, Hosford SR, Jiang A, Marotti JD, Brauer BL, Demidenko E, Miller TW | 2021 | Oncogene | Oncology | HALO | |
In vivo endothelialization and neointimal hyperplasia assessment after rabbit carotid endarterectomy with bovine pericardium | Chen Y, Feng Y, Wang T, Zhang X, Zhang M, Bai X, Li L, Yang K, Ma Y, Zhang Z, Jiao L | 2021 | Annals of Translational Medicine | Myology | Cytonuclear | HALO |
Prognostic role of proliferating CD8+ cytotoxic Tcells in human cancers | Blessin NC, Li W, Mandelkow T, Jansen HL, Yang C, Raedler JB, Simon R, Büscheck F, Dum D, Luebke AM, Hinsch A, Möller K, Menz A, Bernreuther C, Lebok P, Clauditz T, Sauter G, Marx A, Uhlig R, Wilczak W, Minner S, Krech T, Fraune C, Höflmayer D, Burandt E, Steurer S | 2021 | Cellular Oncology | Immuno-oncology | Highplex FL, TMA | HALO |
TNFα secreted by glioma associated macrophages promotes endothelial activation and resistance against anti-angiogenic therapy | Wei Z, Singh O, Ekinci C, Gill J, Li M, Mamatjan Y, Karimi S, Bunda S, Mansouri S, Aldape K, Zadeh G | 2021 | Acta Neuropathologica Communications | Immunology, Neuroscience | Classifier, Multiplex IHC | HALO |
Tumor morphology and location associate with immune cell composition in pleomorphic sarcoma | Wustrack RL, Shao E, Sheridan J, Zimel M, Cho S-J, Horvai AE, Luong D, Kwek SS, Fong L, Okimoto RA | 2021 | Cancer Immunology, Immunotherapy | Immuno-oncology | Cytonuclear | HALO |
Engineered red blood cells as an off-the-shelf allogeneic anti-tumor therapeutic | Zhang X, Lou M, Dastagir SR, Nixon M, Khamhoung A, Schmidt A, Lee A, Subbiah N, McLaughlin DC, Moore CL, Gribble M, Bayhi N, Amin V, Pepi R, Pawar S, Lyford TJ, Soman V, Mellen J, Carpenter CL, Turka LA, Wickham Tj, Chen TF | 2021 | Nature Communications | Oncology | Object Colocalization, Highplex FL | HALO |
Mastocytosis-derived extracellular vesicles deliver miR-23a and miR-30a into pre-osteoblasts and prevent osteoblastogenesis and bone formation | Kim D-K, Bandara G, Cho Y-E, Komarow HD, Donahue DR, Karim B, Baek M-C, Kim HM, Metcalfe DD, Olivera A | 2021 | Nature Communications | Classifier | HALO | |
Mitigation of endemic GI-tract pathogen-mediated inflammation through development of multimodal treatment regimen and its impact on SIV acquisition in rhesus macaques | Bochart RM, Busman-Sahay K, Bondoc S, Morrow DW, Ortiz AM, Fennessey CM, Fischer MB, Shiel O, Swanson T, Shriver-Munsch CM, Crang HB, Armantrout KM, Barber-Axthelm AM, Langner C, Moats CR, Labriola CS, MacAllister R, Axthelm MK, Brenchley JM, Keele BF, Estes JD, Hansen SG, Smedley JV | 2021 | PLOS Pathogens | Infectious Disease | ISH/FISH, Multiplex IHC | HALO |
Mucosal IFNγ production and potential role in protection in Escherichia coli O157:H7 vaccinated and challenged cattle | Schaut RG, Palmer MV, Boggiatto PM, Kudva IT, Loving CL, Sharma VK | 2021 | Scientific Reports | Immunology | ISH/FISH | HALO |
Next-Generation Digital Histopathology of the Tumor Microenvironment | Mungenast F, Fernando A, Nica R, Boghiu B, Lungu B, Batra J, Ecker RC | 2021 | genes | Review | HALO | |
RIPK1 activation mediates neuroinflammation and disease progression in multiple sclerosis | Zelic M, Pontarelli F, Woodworth L, Zhu C, Mahan A, Ren Y, LaMorte M, Gruber R, Keane A, Loring P, Guo L, Xia T, Zhang B, Orning P, Lien E, Degterev A, Hammond T, Ofengeim D | 2021 | Cell Reports | Immunology | HALO | |
Single-cell dissection of cellular components and interactions shaping the tumor immune phenotypes in ovarian cancer | Hornburg M, Desbois M, Lu S, Guan Y, Lo AA, Kaufman S, Elrod A, Lotstein A, DesRochers TM, Munoz-Rodriguez JL, Wang X, Giltnane J, Mayba O, Turley SJ, Bourgon R, Daemen A, Wang Y | 2021 | Cancer Cell | Immuno-oncology | HALO | |
Acute inflammatory profiles differ with sex and age after spinal cord injury | Stewart AN, Lowe JL, Glaser EP, Mott CA, Shahidehpour RK, McFarlane KE, Bailey WM, Zhang B, Gensel JC | 2021 | Journal of Neuroinflammation | Immunology, Neuroscience | HALO | |
Analysis of genomic and non-genomic signaling of estrogen receptor in PDX models of breast cancer treated with a combination of the PI3K inhibitor alpelisib (BYL719) and fulvestrant | Jacquemetton J, Kassem L, Poulard C, Dahmani A, De Plater L, Montaudon E, Sourd L, Morisset L, El Botty R, Chateau-Joubert S, Vacher S, Bièche I, Treilleux I, Trédan O, Marangoni E, Le Romancer M | 2021 | Breast Cancer Research | Oncology | Multiplex IHC | HALO |
AP-3-dependent targeting of flippase ATP8A1 to lamellar bodies suppresses activation of YAP in alveolar epithelial type 2 cells | Kook S, Wang P, Meng S, Jetter CS, Sucre JMS, Benjamin JT, Gokey JJ, Hanby HA, Jaume A, Goetzl L, Marks MS, Guttentag SH | 2021 | Proceedings of the National Academy of Sciences | Fibrosis | HALO | |
Cellular Senescence in Human Aldosterone-Producing Adrenocortical Cells and Related Disorders | Pieroni J, Yamazaki Y, Gao X, Tezuka Y, Ogata H, Omata K, Ono Y, Morimoto R, Nakamura Y, Satoh F, Sasano H | 2021 | Biomedicines | Metabolism | Cytonuclear | HALO |
Functionally distinct POMC-expressing neuron subpopulations in hypothalamus revealed by intersectional targeting | Biglari N, Gaziano I, Schumacher J, Radermacher J, Paeger L, Klemm P, Chen W, Corneliussen S, Wunderlich CM, Sue M, Vollmar S, Klöckener T, Sotelo-Hitschfeld T, Abbasloo A, Edenhofer F, Reimann F, Gribble FM, Fenselau H, Kloppenburg P, Wunderlich FT, Brüning JC | 2021 | Nature Neuroscience | Neuroscience | ISH/FISH | HALO |
SeqStain is an efficient method for multiplexed, spatialomic profiling of human and murine tissues | Rajagopalan A, Venkatesh I, Aslam R, Kirchenbuechler D, Khanna S, Cimbaluk D, Kordower JH, Gupta V | 2021 | Cell Reports Methods | HALO | ||
Novel insulin sensitizer MSDC-0602K improves insulinemia and fatty liver disease in mice, alone and in combination with liraglutide | Kamm DR, Pyles KD, Sharpe MC, Healy LN, Colca JR, McCommis KS | 2021 | Journal of Biological Chemistry | Metabolism | HALO | |
Pathways of immune exclusion in metastatic osteosarcoma are associated with inferior patient outcomes | Ligon JA, Choi W, Cojocaru G, Fu W, Hsiue EH-C, Oke TF, Siegel N, Fong MH, Ladle B, Pratilas CA, Morris CD, Levin A, Rhee DS, Meyer CF, Tam AJ, Blosser R, Thompson ED, Suru A, McConkey D, Housseau F, Anders R, Pardoll DM, Llosa N | 2021 | Journal for ImmunoTherapy of Cancer | Immuno-oncology | Multiplex IHC | HALO |
Predicting nodal metastases in papillary thyroid carcinoma using artificial intelligence | Esce AR, Redemann JP, Sanchez AC, Olson GT, Hanson JA, Argwal S, Boyd NH, Martin DR | 2021 | The American Journal of Surgery | Oncology | HALO | |
Toluidine blue staining of murine mast cells and quantitation by a novel, automated image analysis method using whole slide skin images | Raja N, Naikodi S, Govindarajan A, Palanisamy K | 2021 | Journal of Histotechnology | Immunology | Cytonuclear | HALO |
Pancreatic ? cellselective zinc transporter 8 insufficiency accelerates diabetes associated with islet amyloidosis | Xu J, Wijesekara N, Regeenes R, Al Rijjal D, Piro AL, Song Y, Anne Wu A, Bhattacharjee A, Liu Y, Marzban L, Rocheleau JV, Fraser PE, Dai FF, Hu C, Wheeler MB | 2021 | JCI Insight | Metabolism | HALO | |
Human Type II Taste Cells Express ACE2 and are Infected by SARS-CoV-2 | Doyle M, Ashley Appleton A, Q Liu, Yao Q, Mazucanti C, Egan J | 2021 | American Journal of Pathology | Cytonuclear | HALO | |
Oncogenic BRAF, unrestrained by TGF?-receptor signalling, drives right-sided colonic tumorigenesis | Leach J, Vlahov N, Tsantoulis P, et al | 2021 | Nature Communications | Oncology | ISH/FISH, Highplex FL | HALO |
Attenuating CD3 affinity in a PSMAxCD3 bispecific antibody enables killing of prostate tumor cells with reduced cytokine release | Dang K, Castello G, Clarke S, et al. | 2021 | Journal for Immunotherapy of Cancer | Immuno-oncology | Multiplex IHC | HALO |
Heterogeneity in tertiary lymphoid structure B-cells correlates with patient survival in metastatic melanom | Lynch K, Young S, Menaveau M, et al. | 2021 | Journal for Immunotherapy of Cancer | Immuno-oncology | Highplex FL | HALO |
mRNA translation is a therapeutic vulnerability necessary for bladder epithelial transformation | Jana S, Deo R, Hough R, et al. | 2021 | JCI Insight | Oncology | Multiplex IHC, Highplex FL | HALO |
Approaches for Handling Immunopathological and Clinical Data Using Deep Learning Methodology: Multiplex IHC/IF Data as a Paradigm | Goh S, Chua Y, Lee J, Yeong J, Cai Y | 2021 | Histopathology and Liquid Biopsy | Review | HALO | |
Tumor necroptosis is correlated with a favorable immune cell signature and programmed death-ligand 1 expression in cholangiocarcinoma | Lomphithak T, Akara-amornthum P, Murakami K, et al. | 2021 | Scientific Reports | Immuno-oncology | Highplex FL | HALO |
Multiparametric Analyses of Hepatocellular Carcinoma Somatic Mouse Models and Their Associated Tumor Microenvironment | Taranto D, Ramirez C, Vegna S, et al. | 2021 | Current Protocols | Oncology | Multiplex IHC | HALO |
Quantification of Human Epidermal Growth Factor Receptor 2 by Immunopeptide Enrichment and Targeted Mass Spectrometry in Formalin-Fixed Paraffin-Embedded and Frozen Breast Cancer Tissues | Kennedy J, Whiteaker J, Kennedy L, Bosch D, Lerch M, Schoenherr R, Zhao L, Lin C, Chowdhury S, Kilgore M, Allison K, Wang P, Hoofnagle A, Baird G, Paulovich A | 2021 | Clinical Chemistry | Oncology | Classifier | HALO |
Pathological Change and Whole Transcriptome Alternation Caused by ePTFE Implantation in Myocardium | Shan Y, Zhang W, Chen G, Shi Q, Mi Y, Zhang H, Jia B | 2021 | BioMed Research International | Fibrosis | Area Quantification | HALO |
Detection of Lung Cancer from Whole-Slide Histopathologic Images Using Deep Learning Approach | Mishra N, Behera P, Nanda R, Sahoo M | 2019 | International Journal of Research in Engineering and Sciences | Oncology | Classifier | HALO AI |
Q134R: Small chemical compound with NFAT inhibitory properties improves behavioral performance and synapse function in mouse models of amyloid pathology | Sompol P, Gollihue J, Kraner S, Artiushin I, Cloyd R, Chishti E, Koren S, Nation G, Abisambra J, Huzian O, Nagy L, Santha M, Hackler L, Puskas L, Norris C | 2021 | Aging Cell | Neuroscience | Area Quantification | HALO |
Methods to Determine and Analyze the Cellular Spatial Distribution Extracted From Multiplex Immunofluorescence Data to Understand the Tumor Microenvironment | Parra E | 2021 | Frontiers in Molecular Biosciences | Review | HALO | |
Mismatch repair-deficient prostate cancer with parenchymal brain metastases treated with immune checkpoint blockade | Sena L, Salles D, Engle E, Zhu Q, Tukachinsky H, Lotan T, Antonarakis E | 2021 | Molecular Case Studies | Immuno-oncology | Highplex FL | HALO |
Lawsonia intracellularis infected enterocytes lack sucrase-isomaltase which contributes to reduced pig digestive capacity | Helm E, Burrough E, Leite, F, Gabler, N | 2021 | Veterinary Research | Other | ISH/FISH | HALO |
Mechanism of Nucleic Acid Sensing in Retinal Pigment Epithelium (RPE): RIG-I Mediates Type I Interferon Response in Human RPE | Schustak J, Twarog M, Wu X, Huang Q, Bao Y | 2021 | Journal of Immunology Research | Area Quantification, ISH/FISH | HALO | |
Rejection of benign melanocytic nevi by nevus-resident CD4+ T cells | Schiferle E, Cheon S, Ham S, Son H, Messerschmidt J, Lawrence D, Cohen J, Flaherty K, Moon J, Lian C, Sullivan R, Demehri S | 2021 | Science Advances | Oncology | Multiplex IHC | HALO |
Wound healing with topical BRAF inhibitor therapy in a diabetic model suggests tissue regenerative effects | Escuin-Ordinas H, Liu Y, Hufo W, Dimatteo R, Huang R, Krystofinski P, Azhdam A, Lee J, Comin-Anduix B, Cochran A, Lo R, Segura T, Scumpia P, Ribas A | 2021 | PLOS ONE | Dermatology | Object Colocalization, Multiplex IHC | HALO |
The Goto Kakizaki rat: Impact of age upon changes in cardiac and renal structure, function | Meagher P, Civitarese R, Lee X, Gordon M, Bugyei-Twum A, Desjardins J, Kabir G, Zhang Y, Kosanam H, Visram A, Leong-Poi H, Advani A, Connelly K | 2022 | PLOS ONE | Myology | Muscle Fiber | HALO |
Extensive Three-Dimensional Intratumor Proteomic Heterogeneity Revealed by Multiregion Sampling in High-Grade Serous Ovarian Tumor Specimens | Hunt A, Bateman N, Barakat W, Makohon-Moore S, Hood B, Conrads K, Zhou M, Calvert V, Pierobon M, Loffredo J, Litzi T, Oliver J, Mitchell D, Gist G, Rojas C, Blanton B, Robinson E, Odunsi K, Sood A, Casablanca Y, Darcy K, Schriver C, Petricoin E, Rao U, Maxwell G, Conrads T | 2021 | iScience | Multiplex IHC | HALO | |
Dissecting spatial heterogeneity and the immuneevasion mechanism of CTCs by single-cell RNA-seq in hepatocellular carcinoma | Sun Y, Wu L, Liu S, Jiang M, Hu B, Zhou K, Guo W, Xu Y, Zhong Y, Zhou X, Zhang Z, Liu G, Liu S, Shi Y, Ji Y, Du M, Li N, Li G, Zhao Z, Huang X, Xu L, Yu Q, Peng D, Qiu S, Sun H, Dean M, Wang X, Chung W, Dennison A, Zhou J, Hou Y, Fan J, Yang X | 2021 | Nature Communications | Oncology, Immuno-oncology | Highplex FL | HALO |
TMEM229A suppresses non?small cell lung cancer progression via inactivating the ERK pathway | Zhang X, He Y, Jiang Y, Bao Y, Chen Q, Xie D, Yu H, Wang X | 2021 | Oncology Reports | Multiplex IHC | HALO | |
Glucocorticoid receptor antagonism promotes apoptosis in solid tumor cells | Greenstein A, Hunt H | 2021 | Oncotarget | Multiplex IHC | HALO | |
Anti-tumor effects of RTX-240: an engineered red blood cell expressing 4-1BB ligand and interleukin-15 | McArdel S, Dugast A, Hoover M, Bollampalli A, Hong E, Castano Z Leonard S, Pawar S, Mellen J, Muriuki K, McLaughlin D, Bayhi N, Carpenter C, Turka L, Wickham T, Elloul S | 2021 | Cancer Immunology, Immunotherapy | Immuno-oncology | Highplex FL | HALO |
Immune checkpoint blockade in triple negative breast cancer influenced by B cells through myeloid-derived suppressor cells | Vito A, Salem O, El-Sayes N, MacFawn I, Portillo A, Milne K, Harrington D, Ashkar A, Wan Y, Workenhe S, Nelson B, Bruno T, Mossman K | 2021 | Communications Biology | Immuno-oncology | Cytonuclear | HALO |
Computational pathology reveals unique spatial patterns of immune response in H&E images from COVID-19 autopsies: preliminary findings | Corredor G, Toro P, Bera K, Rasmussen D, Viswanathan V, Buzzy C, Fu P, Barton L, Stroberg E, Duval E, Gilmore H, Mukhopadhyay, Madabhushi A | 2021 | Journal of Medical Imaging | Infectious Disease | HALO Link | |
Spatial mapping of protein composition and tissue organization: a primer for multiplexed antibody-based imaging | Hickey J, Neumann E, Radtke A, Camarillo J, Beuschel R, Albanese A, McDonough E, Hatler J, Wiblin A, Fisher J, Croteau J, Small E, Sood A, Caprioli R, Angelo R Nolan G, Chung K, Hewitt S, Germain R, Spraggins J, Lundberg E, Snyder M, Kelleher N, Saka S | 2021 | arxiv | Review | HALO | |
Chemokine-Capturing Wound Contact Layer Rescues Dermal Healing | Schirmer L, Atallah P, Freudenberg U, Werner C | 2021 | Advanced Science | Dermatology | Highplex FL, Layer Thickness | HALO |
Tertiary lymphoid structures critical for prognosis in endometrial cancer patients - a TransPORTEC study | Horeweg N, Workel, H, Loiero D, Church D, Vermij L, Léon-Castillo A, Krog R, de Boer S, Nout R, Powel M, Mileshkin L, MacKay H, Leary A, Singh N, Jürgenliemk-Schulz I, Creutzberg C, Koelzer V, Nijman H, Bosse T, Bruyn M | 2021 | Research Square | Multiplex IHC, TMA | HALO AI | |
White adipose tissue autophagy and adipose-liver crosstalk exacerbate nonalcoholic fatty liver disease in mice | Sakane S, Hikita H, Shirai K, Myojin Y, Sasaki Y, Kudo S, Fukumoto K, Mizutani N, Tahata Y, Makino Y, Yamada R, Kodama T, Sakamori R, Tatsumi T, Takehara T | 2021 | Cellular and Molecular Gasteroenterology and Hepatology | Metabolism | HALO | |
Neoadjuvant cabozantinib and nivolumab convert locally advanced hepatocellular carcinoma into resectable disease with enhanced antitumor immunity | Ho W, Zhu Q, Durham J, Popovic A, Xavier S, Leatherman J, Mohan A, Mo G, Zhang S, Gross N, Charmsaz S, Lin D, Quong D, Wilt B, Kamel I, Weiss M, Philosophe B, Burkhart R, Burns W, Schubert C, Ejaz A, He J, Deshpande A, Danilova L, Stein-O'Brien G, Sugar E, Laheru D, Anders R, Fertig E, Jaffee, E, Yarchoan M | 2021 | Nature Cancer | Oncology | HALO | |
SMAD4 represses FOSL1 expression and pancreatic cancer metastatic colonization | Dai C, Rennhack J, Arnoff T, Thaker M, Younger S, Doench J, Huang A, Yang A, Aguirre A, Wang B, Mun E, O'Connel J, Huang Y, Labella K, Talamas J, Li J, Ilic N, Hwang J, Hong A, Giacomelli A, Gjoerup O, Root D, Hahn W | 2021 | Cell Reports | Oncology | Area Quantification | HALO |
A single-dose mRNA vaccine provides a long-term protection for hACE2 transgenic mice from SARS CoV-2 | Huang Q, Ji K, Tian S, Wang F, Huang B, Tong Z, Tan S, Hao J, Wang Q, Tan W, Gao G, Yan J | 2021 | Nature Communications | Infectious Disease | Multiplex IHC | HALO |
Endothelial cell infection and dysfunction, immune activation in severe COVID-19 | Qin Z, Liu F, Blair R, Wang C, Yang H, Mudd J, Currey J, Iwanaga N, He J, Mi R, Han K, Midkiff C, Alam M, Aktas B, Heide R, Veazey R, Piedimonte G, Maness N, Ergün S, Mauvais-Jarvis F, Rappaport J, Kolls J, Qin X | 2021 | Theranostics | Immunology, Infectious Disease | Multiplex IHC, Spatial Analysis | HALO |
Histological Studies of the VentricularSubventricular Zone as Neural Stem Cell and Glioma Stem Cell Niche | Brockman A, Mobley B, Rebecca I | 2021 | Journal of Histochemistry & Cytochemistry | Review | HALO | |
The deletion of yeaJ gene facilitates Escherichia coli escape from immune recognition | Wang X, Lin X, Wan Z, Wang S, Zuo J, Wang Z, Xu Y, Han X, Miao J | 2021 | Journal of Bacteriology | HALO | ||
Naproxen chemoprevention promotes immune activation in Lynch syndrome colorectal mucosa | Reyes-Uribe L, Wu Wenhui, Gelincik O, Bommi P, Francisco-Cruz A, Solis L, Lynch P, Lim R, Stoffel E, Kanth P, Samadder N, Mork M, Taggart M, Milne G, Marnett L, Vornik L, Liu D, Revuelta M, Chang K, You Y, Kipelovich L, Wistuba I, Lee J, Sei S, Shoemaker R, Szabo E, Richmond E, Umar A, Perloff M, Brown P, Lipkin S, Vilar E | 2020 | The BMJ | Oncology, Gastroenterology | Classifier, Cytonuclear | HALO |
Repeated porphyrin lipoprotein-based photodynamic therapy controls distant disease in mouse mesothelioma via the abscopal effect | Lou J, Aragaki M, Bernards N, Kinoshita T, Mo J Motooka Y, Ishiwata T, Gregor A, Chee T, Chen Z, Chen J, Kaga K, Wakasa S, Zheng G, Yasufuku K | 2021 | Nanophotonics | Oncology | Cytonuclear | HALO |
Digital pathology in academia: Implementation and impact | Jones-Hall Y | 2021 | Lab Animal | Review | HALO | |
GOT1 inhibition promotes pancreatic cancer cell death by ferroptosis | Kremer D, Nelson B, Lin L, Yarosz E Halbrook C, Kerk S, Sajjakulnukit P, Myers A, Thurston G, Hou S, Carpenter E, Andren A, Nwosu Z, Cusmano N, Wisner S, Mbah N, Shan M, Das N, Magnuson B, Little A, Savani M, Ramos J, Gao T, Sastra S, Palermo C, Badgley M, Zhang L, Asara J, McBrayer S, Pasca di Magliano M, Crawford H, Shah Y, Olive K, Lyssiotis C | 2021 | Nature Communications | Oncology | HALO | |
A preclinical trial and molecularly-annotated patient cohort identify predictive biomarkers in homologous recombination deficient pancreatic cancer | Wang Y, Park J, Pacis A, Denroche R, Jang G, Zhang A, Cuggia A, Domecq C, Monlong J, Raitses-Gurevich M, Grant R, Borgida A, Holter S, Stossel C, Bu S, Masoomian M, Lungu I, Bartlett J, Wilson J, Gao Z, Riazalhosseini Y, Asselah J, Bouganim N, Cabrera T, Boucher L, Valenti D, Biagi J, Greenwood C, Polak P, Foulkes W, Golan T, O'Kane G, Fischer S, Knox J, Gallinger S, Zogopoulos G | 2020 | Clinical Cancer Research | Oncology | Classifier, Cytonuclear, Multiplex IHC | HALO |
Epigenetic modifications precede molecular alterations and drive human hepatocarcinogenesis | Czauderna C, Poplawski A, O'Roourke C, Castven D, Pérez-Aguilar B, Becker D, Heilmann-Heimbach S, Odenthal M, Amer W, Schmiel M, Drebber U, Binder H, Ridder D, Schindeldecker M, Straub B, Galle P, Andersen J, Thorgeirsson S, Park Y, Marquardt J | 2021 | JCI Insight | Oncology | Cytonuclear, TMA | HALO |
Allostatic hypermetabolic response in PGC1?/? heterozygote mouse despite mitochondrial defects | Rodriguez-Cuenca S, Lelliot C, Campbell M, Peddinti G, Martinuez-Uña M, Ingvorsen C, Dias A, Relat J, Mora S, Hyötyläinen T, Zorzano A, Orei? M, Bjursell M, Bohlooly-Y M, Lindén D, Vidal-Puid A | 2021 | The FASEB Journal | Metabolism | Vacuole | HALO |
Distinct immune signatures in peripheral blood predict chemosensitivity in intrahepatic cholangiocarcinoma patients | Wu T, Yang Y, Zheng B, Shi X, Li W, Ma W, Wang S, Li Z, Zhu Y, Wu J, Wang K, Zhao Y, Wu R, Sui C, Shen S, Wu X, Chen L, Yuan Z, Wang H | 2021 | Engineering | Oncology, Immunology | Highplex FL | HALO |
Constrictive and Hypertrophic Strictures in Ileal Crohns Disease | Liu Q, Zhang X, Ko H, Stocker D, Ellman J, Chen J, Hao Y, Bhardwaj S, Liang Y, Cho J, Colombel J, Taouli B, Harpaz N | 2021 | Clinical Gastroenterology and Hepatology | Gastroenterology | HALO | |
The amino acid transporter SLC7A5 is required for efficient growth of KRAS-mutant colorectal cancer | Najumudeen AK, Ceteci F, Fey SK, Hamm G, Steven RT, Hall H, Nikula CJ, Dexter A, Murta T, Race AM, Sumpton D, Vlahov N, Gay DM, Knight JRP, Jackstadt R, Leach JDG, Ridgway RA, Johnson ER, Nixon C, Hedley A, Gilroy K, Clark W, Malla SB, Dunne PD, Rodriguez-Blanco G, Critchlow SE, Mrowinska A, Malviya G, Solovyev D, Brown G, Lewis DY, Mackay GM, Strathdee D, Tardito S, Gottlieb E, CRUK Rosetta Grand Challenge Consortium, Takats Z, Barry ST, Goodwin RJA, Bunch J, Bushell M, Campbell AD, Sansom OJ | 2021 | Nature Genetics | Oncology | ISH/FISH | HALO |
HIF-independent synthetic lethality between CDK4/6 inhibition and VHL loss across species | Nicholson HE, Tariq Z, Housden BE, Jennings RB, Stransky LA, Perrimon N, Signoretti S, Kaelin WG | 2019 | Cancer Therapy | Oncology | HALO | |
Impact of TREM2 risk variants on brain region-specific immune activation and plaque microenvironment in Alzheimer's disease patient brain samples | Prokop S, Miller KR, Labra SR, Pitkin RM, Hoxha K, Narasimhan S, Changolkar L, Rosenbloom A, Lee VM-Y, Trojanowski JQ | 2019 | Acta Neuropathologica | Neuroscience | Classifier, Area Quantification | HALO |
ACT1 is required for murine IL-23-induced psoriasiform inflammation potentially independent of E3 ligase activity | Lipovsky A, Slivka PF, Su Z, Wang Y, Paulsboe S, Wetter J, Namovic MT, Gauvin D, Perron D, Gauld S, McGaragughty S, Goedken ER | 2021 | Journal of Investigative Dermatology | Immunology | Multiplex IHC | HALO |
Robust and persistent reactivation of SIV and HIV by N-803 and depletion of CD8+ cells | McBrien JB, Mavigner M, Li LF, Smith SA, White E, Tharp GK, Walum H, Busman-Suhay K, Aguilera-Sandoval CR, Thayer WO, Spagnuolo RA, Kovarova M, Wahl A, Cervasi B, Margolis DM, Vanderford TH, Carnathan DG, Paiardini M, Lifson JD, Lee JH, Safrit JT, Bosinger SE, Estes JD, Derdeyn CA, Garcia JV, Kulpa DA, Chahroudi A, Silvestri G | 2020 | Nature | Other | ISH/FISH | HALO |
Acute brain inflammation, white matter oxidative stress, and myelin deficiency in a model of neonatal intraventricular hemorrhage | Goulding DS, Vogel RC, Gensel JC, Morganti JM, Stromberg AJ, Miller BA | 2020 | Journal of Neuroscience | Immunology, Neuroscience | Area Quantification, Object Colocalization | HALO |
Pharmacologic modulation of RNA splicing enhances anti-tumor immunity | Lu S, De Neef E, Thomas J, Sabio E, Rousseau B, Gigoux M, Knorr D, Greenbaum B, Elhanti Y, Hogg S, Chow A, Ghosh A, Xie A, Zamarin D, Cui D, Erickson C, Singer M, Cho H, Wang E, Lu B, Durham B, Shah H, Chowell D, Gabel A, Shen Y, Liu J, Jin J, Rhodes M, Taylor R, Molina H, Wolchok J, Merghoub T, Diaz Jr. L, Abdel-Wahab O, Bradley B | 2021 | Cell | Oncology | Multiplex IHC | HALO |
CTLA-4 and PD-1 dual blockade induces SIV reactivation without control of rebound after antiretroviral therapy interruption | Harper J, Gordon S, Chan CN, Wang H, Lindemuth E, Galardi C, Falcinelli SD, Raines SLM, Read JL, Nguyen K, McGary CS, Nekorchuk M, Busman-Sahay K, Schawalder J, King C, Pino M, Micci L, Cervasi B, Jean S, Sanderson A, Johns B, Koblansky AA, Amrine-Madsen H, Lifson J, Margolis DM, Silvestri G, Bar KJ, Favre D, Estes JD, Paiardini | 2020 | Nature Medicine | Immunology, Infectious Disease | Cytonuclear, ISH/FISH | HALO |
Spatially organized multicellular immune hubs in human colorectal cancer | Pelka K, Hofree M, Chen J, Sarkizova S, Pirl J, Jorgji V, Bejnood A, Dionne D, Ge W, Xu K, Chao S, Zollinger D, Lieb D, Reeves J, Fuhrman C, Hoang M, Delorey T, Nguyen L, Waldman J, Klapholz M, Wakiro I, Cohen O, Albers, J, Smillie C, Cuoco M, Wu J, Su M, Yeung J, Vijaykumar B, Magnuson A, Asinovski N, Moll T, Goder-Reise M, Applebaum A, Brais L, DelloStritto L, Denning S, Phillips S, Hill E, Meehan J, Frederick D, Sharova T, Kanodia A, Todres E, Jane-Valbuena J, Biton M, Izar B, Lambden C, Clancy T, Bleday R, Melnitchouk N, Irani J, Kunitake H, Berger D, Srivastava A, Hornick J, Ogino S, Rotem A, Vigneau S, Johnson B, Corcoran R, Sharpe A, Kuchroo V, Ng K, Giannakis M, Nieman L, Boland G, Arguirre A, Anderson A, Rosenblatt-Rosen O, Regev A, Hachohen N | 2021 | Cell | Oncology | Spatial Analysis, Highplex FL | HALO |
Hepatic stellate cells suppress NK cell-sustained breast cancer dormancy | Correia A Guimaraes J, Auf der Maur P, et al. | 2021 | Nature | Immuno-oncology | Classifier | HALO |
Analysis of multispectral imaging with the AstroPath platform informs efficacy of PD-1 blockade | Berry S, Giraldo N, Green B, et al | 2021 | Science | Immuno-oncology | HALO | |
Cabozantinib for neurofibromatosis type 1related plexiform neurofibromas: a phase 2 trial | Fisher MJ, Shih C-S, Rhodes SD, Armstrong AE, Wolters PL, Dombi E, Zhang C, Angus SP, Johnson GL, Packer RJ, Allen JC, Ullrich NJ, Goldman S, Gutmann DH, Plotkin SR, Rosser T, Robertson KA, Widemann BC, Smith AE, Bessler WK, He Y, Park S-J, Mund JA, Jiang L, Bijangi-Vishehsaraei K, Robinson CT, Cutter GR, Korf BR, Neurofibromatosis Clinical Trials Consortium, Blakeley JO, Clapp DW | 2021 | Nature Medicine | Oncology | Area Quantification | HALO |
Olaparib and durvalumab in patients with germline BRCA-mutated metastatic breast cancer (MEDIOLA): an open-label, multicentre, phase 1/2, basket study | Domchek SM, Postel-Vinay S, Im S-A, Park YH, Delord J-P, Italiano A, Alexandre J, You B, Bastian S, Krebs MG, Wang D, Waqar SN, Lanasa M, Rhee J, Gao H, Rocher-Ros V, Jones EV, Gulati S, Coenen-Stass A, Kozarewa I, Lai Z, Angell HK, Opincar L, Herbolsheimer P, Kaufman B | 2020 | The Lancet Oncology | Oncology | Multiplex IHC | HALO |
Artificial Intelligence-Based Quantification of Epithelial Proliferation in Mammary Glands of Rats and Oviducts of Göttingen Minipigs | Hvid H, Skydsgaard M, Jensen NK, Vluff BM, Jensen HE, Oleksiewicz MB, Kvist PH | 2020 | Toxicologic Pathology | Toxicology | Area Quantification | HALO AI |
Interplay of somatic alterations and immune infiltration modulates response to PD-1 blockade in advanced clear cell renal cell carcinoma | Braun DA, Hou Y, Bakouny Z, Ficial M, Sant' Angelo M, Forman J, Ross-Macdonald P, Berger AC, Jegede OA, Elagina L, Steinharter J, Sun M, Wind=Rotolo M, Pignon J-C, Cherniack AD, Lichtenstein L, Neuberg D, Catalano P, Freeman GJ, Sharpe AH, McDermott DF, Van Allen EM, Signoretti S, Wu CJ, Shukla SA, Choueiri TK | 2020 | Nature Medicine | Immuno-oncology | Highplex FL, Partitions (tiles, margins) | HALO |
ARID1A influences HDAC1/BRD4 activity, intrinsic proliferative capacity and breast cancer treatment response | Nagarajan S, Rao SV, Sutton J, Cheeseman D, Dunn S, Papachristou EK, Prada J-EG, Couturier D-L, Kumar S, Kishore K, Chilamakuri CSR, Glont E, Goode EA, Brodie C, Guppy N, Natrajan R, Bruna A, Caldas C, Russel A, Siersbaek R, Yusa K, Chernukhin I, Carroll JS | 2020 | Nature Genetics | Oncology | Multiplex IHC | HALO |
Preoperative ipilimumab plus nivolumab in locoregionally advanced urothelial cancer: the NABUCCO trial | van Dijk N, Gil-Jimenez A, Silina K, Hendricksen K, Smit LA, de Feijter JM, van Montfoort ML, van Rooijen C, Peters D, Broeks A, van der Poel HG, Bruining A, Lubeck Y, Sikorska K, Boellaard TN, Kvistborg P, Vis DJ, Hooijberg E, Schumacher TN, van den Broek M, Wessels LFA, Blank CU, van Rhijn BW, van der Heijden MS | 2020 | Nature Medicine | Immuno-oncology | Classifier, Highplex FL | HALO |
Immunogenic Chemotherapy Enhances Recruitment of CAR-T Cells to Lung Tumors and Improves Antitumor Efficacy when Combined with Checkpoint Blockade | Srivastava S, Furlan SN, Jaeger-Ruckstuhl CA, Sarvothama M, Berger C, Smythe KS, Garrison SM, Specht JM, Lee SM, Amezquita RA, Voillet V, Muhunthan V, Yechan-Gunja S, Pillai SPS, Rader C, Houghton AM, Pierce RH, Gottardo R, Maloney DG, Riddell SR | 2020 | Cancer Cell | Immuno-oncology | Multiplex IHC, Highplex FL | HALO |
HIV-1-induced cytokines deplete homeostatic innate lymphoid cells and expand TCF7-dependent memory NK cells | Wang Y, Lifschitz L, Gellatly K, Vinton CL, Busman-Sahay K, McCauley S, Vangala P, Kim K, Derr, Jaiswall S, Kucukural A, McDonel P, Hunt PW, Greenough T, Houghton J, Somsouk M, Estes JD, Brenchley JM, Garber M, Deeks SG, Luban J | 2020 | Nature Immunology | Immunology, Infectious Disease | Area Quantification, Cytonuclear, ISH/FISH | HALO |
IL6/STAT3 Signaling Hijacks Estrogen Receptor ? Enhancers to Drive Breast Cancer Metastasis | Siersbæk R, Scabia V, Nagarajan S, Chernukhin I, Papachristou EK, Broome R, Johnston SJ, Joosten SEP, Green AR, Kumar S, Jones J, Omarjee S, Alvarez-Fernandez R, Glont S, Aitken SJ, Kishore K, Cheeseman D, Rakha EA, D'Santos C, Zwart W, Ruseel A, Brisken C, Carroll JS | 2020 | Cancer Cell | Oncology | Area Quantification, Multiplex IHC | HALO |
Multimodal treatment combining cold atmospheric plasma and acidic fibroblast growth factor for multi?tissue regeneration | Tan F, Rui X, Xiang X, Yu Z, Al-Rubeai M | 2021 | The FASEB Journal | Other | Multiplex IHC | HALO |
Promyelocytic leukemia protein promotes the phenotypic switch of smooth muscle cells in atherosclerotic plaques of human coronary arteries | Karle W, Becker S, Stenzel P, Knosalla C, Siegel G, Baum O, Zakrzewicz A, Berkholz J | 2021 | Clinical Science | Myology | Area Quantification, Object Colocalization | HALO |
The Unfolded Protein Response Mediator PERK Governs Myeloid Cell-Driven Immunosuppression in Tumors through Inhibition of STING Signaling | Mohamed E, Sierra RA, Trillo-Tinoco J, Cao Y, Innamarato P, Payne KK, Pulido M, Mandula J, Zhang S, Thevenot P, Biswas S, Abdalla SK, Costich TL, Hanggi K, Anadon CM, Flores ER, Haura EB, Mehrotra, Pilon-Thomas S, Ruffel B, Munn DH, Cubillos-Ruiz JR, Conejo-Garcia JR, Rodriguez PC | 2020 | Immunity | Immuno-oncology | Highplex FL | HALO |
Genomic analysis of Vascular Invasion in Hepatocellular Carcinoma (HCC) Reveals Molecular Drivers and Predictive Biomarkers | Krishnan MS, Rajan KD A, Park J, Arjunan V, Marques FJG, Bermudez A, Girvan OA, Hoang NS, Yin J, Nguyen MH, Kothary N, Pitteri S, Felsher DW, Dhanasekaran R | 2020 | Hepatology | Oncology | Multiplex IHC, TMA | HALO |
Dynamic Hydrogels for Prevention of Post?Operative Peritoneal Adhesions | Stapleton LM, Lucian HJ, Grosskopf AK, Smith AAA, Totherow KP, Woo YJ, Appel EA | 2021 | Advanced Therapeutics | Biomaterials | Area Quantification | HALO |
Efficacy and safety of a 3?in?1 antiaging night facial serum containing melatonin, bakuchiol, and ascorbyl tetraisopalmitate through clinical and histological analysis | Goldberg DJ, Mraz-Robinson D, Granger C | 2020 | Journal of Cosmetic Dermatology | Dermatology | Area Quantification, Layer Thickness | HALO |
ILC2-driven innate immune checkpoint mechanism antagonizes NK cell antimetastatic function in the lung | Schuijs MJ, Png S, Richard AC, Tsyben A, Hamm G, Stockis J, Garcia C, Panaud S, Nicholls A, Ros XR, Su J, Eldridge MD, Riedel A, Serrao EM, Rodewald H-R, Mack M, Shields JD, Cohen ES, McKenzie ANJ, Goodwin RJA, Brindle KM, Marioni JC, Halim TYF | 2020 | Nature Immunology | Immuno-oncology | Multiplex IHC | HALO |
Engineering functional microvessels in synthetic polyurethane random-pore scaffolds by harnessing perfusion flow | Wright MEE, Yu JK, Jain D, Maeda A, Yeh S-CA, DaCosta RS, Lin CP, Santerre JP | 2020 | Biomaterials | Biomaterials | Area Quantification | HALO |
Blockade of the co-inhibitory molecule PD-1 unleashes ILC2-dependent antitumor immunity in melanoma | Jacquelot N, Seillet C, Wang M et al. | 2021 | Nature Immunology | Immuno-oncology | Classifier, Highplex FL | HALO |
Expansion of Immature, Nucleated Red Blood Cells by Transient Low?Dose Methotrexate Immune Tolerance Induction in Mice | Tran JQ, Grover D, Zhang M, Stapels M, Brennan R, Bangari DS, Piepenhagen PA, Roberts E, Olivia P, Zubair F, Vela JL, Richards SM, Joseph AM | 2020 | Clinical & Experimental Immunology | Immunology | Area quantification | HALO |
The InSituPlex® Staining Method for Multiplexed Immunofluorescence Cell Phenotyping and Spatial Profiling of Tumor FFPE Samples | Manesse M, Patel KK, Bobrow M, Downing SR | 2020 | Biomarkers for Immunotherapy of Cancer | Oncology, Immuno-oncology | Highplex FL | HALO |
Highly efficient genome editing in primary human bronchial epithelial cells differentiated at air-liquid interface | Rapiteanu R, Karagyozova T, Zimmerman N, Singh K, Wayne G, Martufi M, Belyaev NN, Hessel EM, Michalovich D, Macarron R, Rowan WC, Cairns WJ, Roger J, Betts J, Beinke S, Maratou K | 2020 | European Respiratory Journal | Other | Highplex FL | HALO |
IBI112, a selective anti-IL23p19 monoclonal antibody, displays high efficacy in IL-23-induced psoriasiform dermatitis | Li L, Wu Z, Qiu X, Wu Y, Kuang Z, Wang L, Sun T, Liu Y, Yi S, Jing H, Zhou S, Chen B, Wu, D, Wu W, Liu J | 2020 | International Immunopharmacology | Immunology, Dermatology | Classifier, Layer Thickness | HALO |
A four-chemokine signature is associated with a T cell-inflamed phenotype in primary and metastatic pancreatic cancer | Romero JM, Grünwald BT, Jang G-H, Bavi PP, Jhaveri A, Masoomian M, Fischer SE, Zhang A, Denroche RE, Lungu IM, De Luca A, Bartlett JMS, Xu J, Li N, Dhaliwal S, Liang S-B, Chadwick D, Vyas F, Bronsert P, Khokha R, McGaha TL, Notta F, Ohashi PS, Done SJ, O'Kane GM, Wilson JM, Knox JJ, Connor A, Wang Y, Zogopoulos G, Gallinger S | 2020 | Clinical Cancer Research | Oncology | Immune | HALO |
A Dedicated Evolutionarily Conserved Molecular Network Licenses Differentiated Cells to Return to the Cell Cycle | Miao Z-F, Lewis MA, Cho CJ, Adkins-Threats M, Park D, Brown JW, Sun J-X, Burclaff JR, Kennedy S, Lu J, Mahar M, Vietor I, Huber LA, Davidson NO, Cavalli V, Rubin DC, Wang Z-N, Mills JC | 2020 | Developmental Cell | Oncology | Highplex FL | HALO |
Immune evasion before tumour invasion in early lung squamous carcinogenesis | Mascaux C, Angelova M, Vasaturo A, Beane J, Hijazi K, Anthoine G, Rothe F, Willard-Gallo K, Haller A, Ninane V, Burny A, Sculier J-P, Spira A, Galon J | 2019 | Nature | Oncology, Immuno-oncology | Multiplex-IHC | HALO |
Mobilization of CD8+ T cells via CXCR4 blockade facilitates PD-1 checkpoint therapy in human pancreatic cancer | Seo YD, Jiang X, Sullivan KM, Jalikis FG, Smythe KS, Abbasi A, Vignali M, Park JO, Daniel SK, Pollack SM, Kim TS, Yeung R, Crispe IN, Pierce RH, Robins H, Pillarisetty VG | 2019 | Clinical Cancer Research | Immuno-oncology | Cytonuclear | HALO |
STAT3 antisense oligonucleotide remodels the suppressive tumor microenvironment to enhance immune activation in combination with anti-PD-L1 | Proia T, Singh M, Woessner R, Carnevalli LS, Bommakanti G, Magiera L, Srinivasan SS, Grosskurth SE, Collins M, Womack C, Griffin M, Ye M, Cantin S, Russell DL, Xie M, Hughes AM, Deng N, Mele DA, Fawell SE, Barry ST, Reimer C, Barrett JC, McCoon P | 2020 | Clinical Cancer Research | Immuno-oncology | Multiplex IHC, Highplex FL | HALO |
Imaging Tumor-Infiltrating Lymphocytes in Brain Tumors with [64Cu]Cu-NOTA-anti-CD8-Positron Emission Tomography | Nagle V, Henry K, Hertz C, et al. | 2021 | Clinical Cancer Research | Immuno-oncology | Multiplex IHC | HALO |
Cooperative targeting of immunotherapy-resistant melanoma and lung cancer by an AXL-targeting antibody-drug conjugate and immune checkpoint blockade | Boshuizen J, Pencheva N, Krijgsman O, Altimari DD, Castro PG, de Bruijn B, Ligtenberg MA, den Heuvel EG, Vredevoogd DW, Song J-Y, Visser N, Apriamashvili G, Janmaat ML, Plantinga TS, Franken P, Houtkamp M, Lingnau A, Jure-Kunkel M, Peeper DS | 2021 | Cancer Research | Immuno-oncology | Multiplex-IHC | HALO |
Over-expression of Th2-related molecules in the skin of patients with eosinophilic dermatosis of hematologic malignancy | Maglie R, Ugolini F, De Logu F, Nassini R, Simi S, Nardiello P, Pasqualaini E, Baroini G, Del Bianco E, Massi D, Antiga E | 2021 | Journal of the American Academy of Dermatology | Oncology, Immuno-oncology | Area Quantification, Multiplex IHC | HALO Link |
Temporal Analysis of Amylase Expression in Control, Autoantibody Positive, and Type 1 Diabetes Pancreatic Tissues | Kusmartseva I, Beery M, Hiller H, Padilla M, Selman S, Posgai A, Nick HS, Campbell-Thompson M, Schatz DA, Haller MJ, Wasserfall CH, Atkinson MA | 2019 | Diabetes | Metabolism | Cytonuclear | HALO |
Kras and Lkb1 mutations synergistically induce intraductal papillary mucinous neoplasm derived from pancreatic duct cells | Collet L, Ghurburrun E, Meyers N, Assi M, Pirlot B, Leclercq IA, Couvelard A, Komuta M, Cros J, Demetter P, Lemaigre FP, Borbath I, Jacquemin P | 2019 | Gut | Oncology | Area Quantification | HALO |
Prognostic features of the tumour microenvironment in oesophageal adenocarcinoma | McShane R, Arya S, Stewart A, Caie P, Bates M | 2021 | Biochimica et Biophysica Acta (BBA) - Reviews on Cancer | Immuno-oncology, Review | Cytonuclear | HALO |
Mammalian Retinal Cell Quantification | Muthuswamy A, Chen H, Hu Y, Turner OC, Aina OH | 2020 | Toxicologic Pathology | Other | Cytonuclear | HALO |
Cx43 phosphorylation sites regulate pancreatic cancer metastasis | Solan JL, Hingorani SR, Lampe PD | 2021 | Oncogene | Oncology | Classifier, Area Quantification | HALO |
MAOA-mediated reprogramming of stromal fibroblasts promotes prostate tumorigenesis and cancer stemness | Li J, Pu T, Yin L, Li Q, Liao C-P, Wu BJ | 2020 | Oncogene | Oncology | Multiplex IHC | HALO |
Multimodal In Vivo and Post-mortem Assessments of Tau in Lewy Body Disorders | Coughlin DG, Phillips JS, Roll E, Peterson C, Lobrovich R, Rascovsky K, Ungrady M, Wolk DA, Das S, Weintraub D, Lee EB, Trojanowski JQ, Shaw LM, Vaishnavi S, Siderowf A, Nasrallah IM, Irwin DJ, McMillan CT | 2020 | Neurobiology of Aging | Neuroscience | Area Quantification | HALO |
B7-H3 immune checkpoint expression is a poor prognostic factor in colorectal carcinoma | Lu Z, Zhao Z-X, Cheng P, Huang F, Guan X, Zhang M-G, Chen H-P, Liu Z, Jiang Z, Zheng Z-X, Zou S-M, Wang X-S | 2020 | Modern Pathology | Immuno-oncology | Multiplex-IHC, TMA | HALO |
Chemoradiotherapy efficacy is predicted by intra-tumour CD8+/FoxP3+ double positive T cell density in locally advanced N2 nonsmall-cell lung carcinoma | Boulle G, Velut Y, Mansuet-Lupo A, Gibault L, Blons H, Fournel L, Boni A, Cremer I, Wislez M, Duchatelle V, Tredaniel J, Hammond SA, Herbst R, Alifano M, Giraud P, Damotte D | 2020 | European Journal of Cancer | Oncology | Highplex FL | HALO |
Neonatal hydrocephalus leads to white matter neuroinflammation and injury in the corpus callosum of Ccdc39 hydrocephalic mice | Goulding DS, Vogel RC, Pandya CD, Shula C, Gensel JC, Mangano FT, Goto J, Miller BA | 2020 | Journal of Neurosurgery | Immunology, Neuroscience | Multiplex IHC, Highplex FL | HALO |
The RAC1 target NCKAP1 plays a crucial role in progression of BRAF/PTEN -driven melanoma in mice | Swaminathan K, Campbell A, Papalazarou V, Jaber-Hijazi F, Nixon C, McGhee E, Strathdee D, Sansom OJ, Machesky LM | 2020 | Journal of Investigative Dermatology | Oncology, Dermatology | Area Quantification, Multiplex IHC | HALO |
Intraductal pancreatic cancer is less responsive than cancer in the stroma to neoadjuvant chemotherapy | Fujikura K, Hutchings D, Braxton AM, Zhu Q, Laheru DA, Hruban RH, Thompson ED, Wood LD | 2020 | Modern Pathology | Oncology | Multiplex IHC | HALO |
Phosphorylation of connexin 43 at MAPK, PKC or CK1 sites each distinctly alter the kinetics of epidermal wound repair | Lastwika JK, Dunn CA, Solan JL, Lampe PD | 2019 | Journal of Cell Science | Dermatology | Cytonuclear | HALO |
T-regulatory cells predict clinical outcome in soft tissue sarcoma patients: a clinico-pathological study | Smolle M, Herbsthofer L, Granegger B, Goda M, Brcic I, Bergovec M, Scheipl S, Prietl B, Pichler M, Gerger A, Rossmann C, Riedl J, Tomberger M, López-García P, El-Heliebi A, Leithner A, Liegl-Atzwanger B, Szkandera J | 2021 | British Journal of Cancer | Oncology | Highplex FL, TMA | HALO |
Quantitative digital image analysis of tumor-infiltrating lymphocytes in HER2-positive breast cancer | Abe N, Matsumoto H, Takamatsu R, Tamaki K, Takigami N, Uehara K, Kamada Y, Tamaki N, Motonari T, Unesoko M, Nakada N, Zaha N, Zaha H, Yoshimi N | 2019 | Vichows Archiv | Oncology | Classifier, Cytonuclear | HALO |
RNA isoform screens uncover the essentiality and tumor-suppressor activity of ultraconserved poison exons | Thomas JD, Polaski JT, Feng Q, De Neef EJ, Hoppe ER, McSharry MV, Pangallo J, Gabel AM, Belleville AE, Watson J, Nkinsi NT, Berger AH, Bradley RK | 2020 | Nature Genetics | Other | Highplex FL | HALO |
Glucagon Receptor Inhibition Reduces Hyperammonemia and Lethality in Male Mice with Urea Cycle Disorder | Cavino K, Sung B, Su Q, Na E, Kim J, Cheng X, Gromada J, Okamoto H | 2020 | Endocrinology | Metabolism | ISH/FISH, Multiplex IHC | HALO |
Characterization of the tumor immune microenvironment in human papillomavirus-positive and -negative head and neck squamous cell carcinomas | Succaria F, Kvistborg P, Stein JE, Engle EL, McMiller TL, Rooper LM, Thompson E, Berger AE, van den Brekel M, Zuur CL, Haanen J, Topalian SL, Taube JM | 2020 | Cancer Immunology, Immunotherapy | Immuno-oncology | Immune | HALO |
Temporospatial Development of Neuropathologic Findings in a Canine Model of Mucopolysaccharidosis IIIB | Harm TA, Hostetter SJ, Nenninger AS, Valentine BN, Ellinwood NM, Smith JD | 2020 | Veterinary Pathology | Immunology, Neruoscience | Area Quantification, Cytonuclear | HALO |
Development of a clinically relevant ovarian cancer model incorporating surgical cytoreduction to evaluate treatment of micro-metastatic disease | Morse CB, Voillet V, Bates BM, Chiu EY, Garcia NM, Gottardo R, Greenberg PD, Anderson KG | 2020 | Gynecologic Oncology | Oncology | Multiplex IHC | HALO |
PIK3CA mutation and CNV status and post-chemoradiotherapy survival in patients with cervical cancer | Martell K, McIntyre JB, Kornaga EN, Chan AMY, Phan T, Kobel M, Enwere EK, Dean ML, Ghatage P, Lees-Miller SP, Doll CM | 2020 | Gynecologic Oncology | Oncology | Classifier, Highplex FL, TMA | HAO |
Tumor Platinum Concentrations and Pathological Responses Following Cisplatin-Containing Chemotherapy in Gastric Cancer Patients | Cao Y, Chang Q, Cabanero M, Zhang W, Hafezi-Bakhtiari S, Hedley D, Darling G, Quereshy F, Jang R, Elimova E, Knox J, Ornatsky O, Serra S, Chen E | 2019 | Journal of Gastrointestinal Cancer | Oncology | Area Quantification, Cytonuclear | HALO |
PLX3397 treatment inhibits constitutive CSF1R-induced oncogenic ERK signaling, reduces tumor growth, and metastatic burden in osteosarcoma | Smeester BA, Slipek NJ, Pomeroy EJ, Laoharawee K, Osum SH, Larsson AT, Williams KB, Stratton N, Yamamoto K, Peterson JJ, Rathe SK, Mills LJ, Hudson WA, Crosby MR, Wang M, Rahramann EP, Moriarity SB, Largaespada DA | 2020 | Bone | Oncology | Cytonuclear, TMA | HALO |
IFN-III is selectively produced by cDC1 and predicts good clinical outcome in breast cancer | Hubert M, Gobbini E, Couillault C, Manh T-PV, Doffin A-C, Berthet J, Rodriguez C, Ollion V, Kielbassa J, Sajous C, Treilleux I, Tredan O, Dubois B, Dalod M, Bendriss-Vermare N, Caux C, Valladeau-Guilemond J | 2020 | Immunology | Oncology | Highplex FL, Partitions (tiles, margins) | HALO |
Using immuno-PET imaging to monitor kinetics of T cell-mediated inflammation and treatment efficiency in a humanized mouse model for GvHD | Pektor S, Schlöder J, Klasen B, Bausbacher N, Wagner D-C, Schreckenberger W, Grabbe S, Jonuleit H, Miederer M | 2019 | European Journal of Nuclear Medicine and Molecular Imaging | Immunology | Cytonuclear | HALO |
Association between CD8 and PD?L1 expression and outcomes after radical prostatectomy for localized prostate cancer | Vicier C, Ravi P, Kwak L, Werner L, Huang Y, Evan C, Loda M, Hamid AA, Sweeney CJ | 2020 | The Prostate | Immuno-oncology | Classifier, Highplex FL | HALO |
?-Synuclein modulates tau spreading in mouse brains | Bassil F, Meymand ES, Brown HJ, Xu H, Cox TO, Pattabhiraman S, Maghames CM, Wu Q, Zhang B, Trojanowski JQ, Lee VM-Y | 2020 | Journal of Experimental Medicine | Neuroscience | Area Quantification | HALO |
A locus coeruleus to dentate gyrus noradrenergic circuit modulates aversive contextual processing | Seo D, Zhang E, Piantadosi S, et al | 2021 | Neuron | Neuroscience | Area Quantification, Highplex FL | HALO |
Clinicopathological significance of nerves in esophageal cancer | Griffin N, Rowe CW, Gao F, Jobling P, Wills V, Walker MM, Faulkner S, Hondermarck H | 2020 | The American Journal of Pathology | Oncology | Area Quantification | HALO |
AST-120 Treatment Alters the Gut Microbiota Composition and Suppresses Hepatic Triglyceride Levels in Obese Mice | Hiraga Y, Kubota T, Katoh, M, et al. | 2021 | Endocrine Research | Metabolism | Vacuole | HALO |
High CD8+ tumour infiltrating lymphocyte density associates with unfavourable prognosis in oesophageal adenocarcinoma following poor response to neo?adjuvant chemoradiotherapy | Koemans WJ, van Dieren JM, van den Berg J, Meijer G, Snaebjornsson P, Chalabi M, Lecot F, Riedl R, Krijgsman O, Hofland I, Broeks A, Voncken FEM, Peppelenbosch MP, Sosef MN, van Sandick JW, Kodach LL | 2021 | Histopathology | Immuno-oncology | Cytonuclear | HALO |
High density of cytotoxic T-lymphocytes is linked to tumoral PD-L1 expression regardless of the mismatch repair status in colorectal cancer | Möller K, Blessin N, Höflmayer D, et al. | 2021 | Acta Oncologica | Immuno-oncology | Highplex FL | HALO |
Discoidin Domain Receptor 1 (DDR1) is Necessary for Tissue Homeostasis in Pancreatic Injury and Pathogenesis of Pancreatic Ductal Adenocarcinoma | Ruggeri JM, Franco-Barraza J, Sohail A, Zhang Y, Long D, di Magliano MP, Cukierman E, Fridman R, Crawford HC | 2020 | The American Journal of Pathology | Oncology, Immunology | Cytonuclear, Multiplex IHC, Highplex FL | HALO |
Chronic stress differentially alters mRNA expression of opioid peptides and receptors in the dorsal hippocampus of female and male rats | Johnson MA, Contoreggi NH, Kogan JF, Bryson M, Rubin BR, Gray JD, Kreek MJ, McEwen BS, Milner TA | 2021 | The Journal of Comparative Neurology | Neruoscience | ISH/FISH | HALO |
Monocyte and macrophage derived myofibroblasts: Is it fate? A review of the current evidence | Vierhout M, Ayoub A, Naiel S, Yazdanshenas P, Revill S, Reihani A, Dvorkin-Gheva A, Shi W, Ask K | 2021 | Wound Repair and Regeneration | Review | ISH/FISH | HALO |
Necroptosis in biliary atresia of the liver | Hashimoto M, Fujishima F, Lomphithak T, Jitkaew S, Nio M, Sasano H | 2021 | Medical Molecular Morphology | Metabolism | Multiplex IHC | HALO |
Intracranial administration of alpha-synuclein fibrils in A30P-synuclein transgenic mice causes robust synucleinopathy and microglial induction | Gentzel R, Toolan D, Jinn S, Schachter J, Ma L, Kahle P, Smith S, Marcus J | 2021 | Neurobiology of Aging | Neuroscience | Area Quantification | HALO |
A comparative study of cirrhosis sub-staging using the Laennec system, Beijing classification, and morphometry | Zhang X, Schiano T, Doyle E, Branch A, Florman S, Fiel M. | 2021 | Modern Pathology | Metabolism | Classifier, Area Quantification | HALO |
Alteration of Colonic Mucin Composition and Cytokine Expression in Acute Swine Dysentery | Lin S J-H, Arruda B, Burrough E | 2021 | Veterinary Pathology | Immunology | Area Quantification, ISH/FISH | HALO |
Selective loss of resident macrophage-derived insulin-like growth factor-1 abolishes adaptive cardiac growth to stress | Zaman R, Hamidzada H, Kantores C, Wong A, Dick S, Wang Y, Momen A, Aronoff L, Lin J, Razani B, Mital S, Billia F, Lavine K, Nejat S, Epelman S | 2021 | Immunity | Immunology | Highplex FL | HALO |
Ki-67 Proliferation Index Assessment in Gastroenteropancreatic Neuroendocrine Tumors by Digital Image Analysis With Stringent Case and Hotspot Level Concordance Requirements | Boukhar SA, Gosse MD, Bellizzi AM, Rajan A | 2021 | American Journal of Clinical Pathology | Oncology | Cytonuclear | HALO |
Establishing standardized immune phenotyping of metastatic melanoma by digital pathology | Sobottka B, Nowak M, Frei A, Haberecker M, Merki S, Tumor Profiler consortium, Levesque M, Dummer R, Moch H, Koelzer V | 2021 | Laboratory Investigation | Immuno-oncology | Multiplex IHC, Spatial Analysis | HALO AI |
Orexin receptors 1 and 2 in serotonergic neurons differentially regulate peripheral glucose metabolism in obesity | Xiao X Yeghiazaryan G, Hess S, Klemm P, Sieben A, Kleinridders A, Morgan D, Wunderlich F. Rahmouni K. Kong D, Scammell T, Lowell B, Kloppenburg P, Brüning J, Hausen A. | 2021 | Nature Communications | Metabolism | ISH/FISH | HALO |
Multiplex Immunohistochemical Phenotyping of T Cells in Primary Prostate Cancer | Ozbek B, Ertunc O, Erickson A, Vidal I, Alexandre C, Guner G, Hicks J, Jones T, Taube J, Sfanos K, Yegnasubramanian S, DeMarzo A | 2021 | medRxiv | Immuno-oncology | Classifier, Cytonuclear, Highplex FL, Serial Section, Registration | HALO |
Simultaneous targeting of TGF-b/PD-L1 synergizes with radiotherapy by reprogramming the tumor microenvironment to overcome immune evasion | Lan Y, Moustaga M, Knoll M, Xu C, Furkel J, Lazorchak A, Yeung T, Hasheminasab S, Jenkins M, Meister S, Yu H, Schlegel J, Marelli B, Tang Z, Qin G, Klein C, Qi J, Zhou C, Locke G, Krunic D, Derner M, Schwager C, Fontana R, Kriegsmann K, Jiang F, Rein K, Kriegsmann M, Debus J, Lo K, Abdollahi A | 2021 | Cancer Cell | Oncology | Cytonuclear | HALO |
SLFN11 captures cancer-immunity interactions associated with platinum sensitivity in high-grade serous ovarian cancer | Winkler C, King M, Berthe J, Ferraioli D, Garuti A, Grillo F, Rodriguez-Canales J, Ferrando L, Chopin N, Ray-Coquard I, Delpuech O, Bedognetti D, Ballestrero A, Leo E, Zoppoli G | 2021 | JCI Insight | Oncology | Classifier, Cytonuclear | HALO |
Three subtypes of lung cancer fibroblasts definedistinct therapeutic paradigms | Hu H, Peotrowska Z, Hare P, Chen H, Mulvey H, Mayfield A, Noeen S, Kattermann K, Greenberg M, Williams A, Riley A, Wilson J, Mao Y, Huang R, Banwait M, Ho J, Crowther G, Hariri L, Sequist L, Benes C, Niederst M, Engelman J | 2021 | Cancer Cell | Oncology | Cytonuclear, ISH/FISH | HALO |
NR4A1 regulates expression of immediate early genes, suppressing replication stress in cancer | Guo H, Golczer G, Wittner B, Langenbucher A, Zachariah M, Dubash T, Hong X, Comaills V, Burr R, Ebright R, Horwitz E, Vuille J, Hajizadeh S, Wiley D, Reeves B, Zhang J, Niederhoffer K, Lu C, Wesley B, Ho U, Nieman L, Toner M, Vasudevan S, Zou L, Mostoslavsky R, Maheswaran S, Lawrence M, Haber D | 2021 | Molecular Cell | Oncology | Highplex FL | HALO |
AG-205 Upregulates Enzymes Involved in Cholesterol Biosynthesis and Steroidogenesis in Human Endometrial Cells Independently of PGRMC1 and Related MAPR Proteins | Thieffry C, Van Wynendaele M, Aynaci A, Maja M, Dupuis C, Loriot A, Marbaix E, Henriet P | 2021 | Biomolecules | Other | Cytonuclear, Highplex FL | HALO |
p53-mediated redox control promotes liver regeneration and maintains liver function in response to CCl4 | Humpton T, Hall H, Kiourtis C, Nixon C, Clark W, Hedley A, Shaw R, Bird T, Blyth K, Vousden K | 2021 | Cell Death & Differentiation | Metabolism | Cytonuclear, Multiplex IHC | HALO |
Single-cell RNA transcriptome landscape of hepatocytes and non-parenchymal cells in healthy and NAFLD mouse liver | Su Q, Kim S, Adewale F, Zhou Y, Alder C, Ni M, Wei Y, Burcznski M, Atwal G, Sleeman M, Murphy A, Xin Y, Cheng X | 2021 | iScience | Metabolism | Area Quantification | HALO |
Functional heterogeneity of POMC neurons relies on mTORC1 signaling | Saucisse N, Mazier W, Simon V, Binder E, Catania C, Bellocchio L, Romanov R, Leon S, Matias I, Zizzari P, Quarta C, Cannich A, Meece K, Gonzales D, Clark S, Becker J, Yeo G, Fioramonti X, Merkle F, Wardlaw S, Harkany T, Massa F, Marsicano G, Cota D | 2021 | Cell Reports | Neuroscience | ISH/FISH | HALO |
Atypical chemokine receptor 3 (ACKR3) induces the perturbation of rRNA biogenesis in colonic cells: a novel mechanism of colorectal tumorigenesis | Yang J, Li Y, Pan T, Miao R, Zhang Y, Wu S, Qu X, Cui S | 2021 | Research Square | Oncology | Area Quantification | HALO |
IL-1-driven stromalneutrophil interactions define a subset of patients with inflammatory bowel disease that does not respond to therapies | Friedrich M, Pohin M, Jackson M, Korsunsky I, Bullers S, Rue-Albrecht K, Christoforidou Z, Sathananthan D, Thomas T, Ravindran R, Tandon R, Peres R, Sharpe H, Wei K, Watts G, Mann E, Geremia A, Attar M, Oxford IBD Cohort Investigators, Roche Fibroblast Network Consortium, McCuaig S, Thomas L, Collantes E, Uhlig H, Sansom S, Easton A, Raychaudhuri S, Travis S, Powrie F | 2021 | Nature Medicine | Gastroenterology | Cytonuclear | HALO |
Increased IL-6 expression precedes reliable viral detection in the rhesus macaque brain during acute SIV infection | Gopalakrishnan R, Aid M, Mercado N, Davis C, Malik S, Geiger E, Varner V, Jones R, Bosinger S, Piedra-Mora C, Martinot A, Barouch D, Reeves R, Tan C | 2021 | JCI Insight | Infectious Disease | Area Quantification | HALO |
Combined CTLA-4 and PD-L1 blockade in patients with chemotherapy-naïve metastatic castration-resistant prostate cancer is associated with increased myeloid and neutrophil immune subsets in the bone microenvironment | Subudhi S, Siddiqui B, Aparicio A, Yadav S, Basu S, Chen H, Jindal S, Tidwell R, Varma A, Logothetis C, Allison J, Corn P, Sharma P | 2021 | Journal for ImmunoTherapy of Cancer | Immuno-oncology | Cytonuclear, Multiplex IHC | HALO |
Expression of SARS-CoV-2 Entry Factors in the Pancreas of Normal Organ Donors and Individuals with COVID-19 | Kusmartseva I, Wu W, Syed F, Van Der Heide V, Jorgensen M, Joseph P, Tang X, Candelario-Jalil E, Yang C, Nick H, Harbert J, Posgai A, Paulsen J, Lloyd R, Cechin S, Pugliese A, Campbell-Thomson M, Vander Heide R, Evans-Molina C, Homann D, Atkinson M | 2020 | Cell Metabolism | Infectious Disease | Area Quantification | HALO |
Baricitinib Treatment Resolves Lower-Airway Macrophage Inflammation and Neutrophil Recruitment in Sars-Cov-2-Infected Rhesus Macaques | Hoang T, Pino M, Boddapati A, Viox E, Starke C, Upadhyay A, Gumber S, Nekorchuk M, Busman-Sahay K, Strongin Z, Harper J, Tharp G, Pellegrini K, Kirejczyk S, Zandi K, Tao S, Horton T, Beagle E, Mahar E, Lee M, Cohen J, Jean S, Wood J, Connor-Stroud F, Stammen R, Delmas O, Wang S, Cooney K, Sayegh M, Wang L, Filev P, Weiskopf D, Silvestri G, Waggoner J, Piantadosi A, Kasturi S, Al-Shakhshir H, Ribeiro S, Sekaly R, Levit R, Estes J, Vanderfold T, Schinazi R, Bosinger S, Paiardine M | 2021 | Cell | Infectious Disease | Multiplex IHC | HALO |
Diagnostic and prognostic implications of a three-antibody molecular subtyping algorithm for non-muscle invasive bladder cancer | Jackson C, Chen L, Hardy C, Ren K, Visram K, Bratti V, Johnstone J, Sjödahl G, Siemens D, Gooding R, Berman D | 2021 | The Journal of Pathology: Clinical Research | Oncology | Cytonuclear, TMA | HALO |
Transcriptomic Analysis of Healthy and Atopic Dermatitis Samples Reveals the Role of IL-37 in Human Skin | Zhou J, Gemperline D, Turner M, Oldach J, Molignano J, Sims J, Stayrook K | 2021 | ImmunoHorizons | Dermatology | Area Quantification, Cytonuclear | HALO |
Interleukin-33 activates group 2 innate lymphoid cell expansion and modulates endometriosis | Miller J, Lingegowda H, Symons L, Bougie O, Young S, Lessey B, Koti M, Tayade C | 2021 | JCI Insight | Other | Area Quantification, Cytonuclear | HALO |
Development of a novel humanized mouse model for improved evaluation of in vivo anti-cancer effects of anti-PD-1 antibody | Katano I, Hanazawa A, Otsuka I, Yamaguchi T, Mochizuki M, Kawai K, Ito R, Goto M, Kagawa T, Takahashi T | 2021 | Scientific Reports | Oncology | Cytonuclear, Multiplex IHC | HALO |
A comparability study of natural and deglycosylated PD-L1 levels in lung cancer: evidence from immunohistochemical analysis | Mei J, Xu J, Yang X, Gu D, Zhou W, Wang H, Liu C | 2021 | Molecular Cancer | Oncology | Cytonuclear, Multiplex IHC | HALO |
Automated Detection and Classification of Desmoplastic Reaction at the Colorectal Tumour Front Using Deep Learning | Nearchou I, Ueno H, Kajiwara Y, Lillard K, Mochizuki S, Takeuchi K, Harrison D, Caie P | 2021 | Cancers | Oncology | HALO AI | |
Mitochondria exert age-divergent effects on recovery from spinal cord injury | Stewart A, McFarlane K, Vekaria H, Bailey W, Slone S, Tranthem L, Zhang B, Patel S, Sullivan P, Gensel J | 2021 | Experimental Neurology | Neuroscience | Object Colocalization | HALO |
Large-Section Histopathology Can Better Indicate the Immune Microenvironment and Predict the Prognosis of Pancreatic Ductal Adenocarcinoma Than Small-Section Histopathology | Ding G, Guo M, Yang Y, Sun C, Wu S, Liu X, Wang J, Jiang H, Liu Y, Zheng J | 2021 | Frontiers in Oncology | Oncology | Multiplex IHC | HALO |
Androgen Receptor Signalling in Macrophages Promotes TREM-1-mediated Cancer Cell Line Migration and Invasion | Cioni B, Zaalberg A, van Beihnum J, Melis M, van Brugsteden J, Muraro M, Hooijberg E, Peters D, Hofland I, Lubeck Y, de Jong J, Sanders J, Vivie J, van der Poel J, Griffioen A, Zwart W, Bergman A | 2021 | Nature Communications | Oncology | Highplex FL, Partitions (tiles, margins) | HALO |
Dysregulation of Innate Lymphoid Cells in Patients with Active Rheumatoid Arthritis and Mice with Collagen-Induced Arthritis | Yang F, Luo X, Zhu W, Li J, Zheng Z, Zhu P | 2021 | Mediators of Inflammation | Spatial Analysis, Highplex FL | HALO | |
CD147 antibody specifically and effectively inhibits infection and cytokine storm of SARS-CoV-2 and its variants delta, alpha, beta, and gamma | Geng J, Chen L, Yuan Y, Wang K, Wang Y, Qin C, Wu G, Chen R, Zhang Z, Wei D, Du P, Zhang J, Lin P, Zhang K, Deng Y, Xu K, Liu J, Sun X, Guo T, Yang X, Wu J, Jiang J, Li L, Zhang K, Wang Z, Zhang J, Yan Q, Zhu H, Zheng Z, Miao J, Fu X, Yang F, Chen X, Tang H, Zhang Y, Shi Y, Zhu Y, Pei Z, Huo F, Liang X, Wang Y, Wang Q, Xie W, Li Y, Shi M, Bian H, Zhu P, Chen Z | 2021 | Signal Transduction and Targeted Therapy | Infectious Disease | Cytonuclear, Multiplex IHC, Highplex FL | HALO |
Suppression of insulin-induced gene 1 (INSIG1) function promotes hepatic lipid remodelling and restrains NASH progression | Azzu V, Vacca M, Kamzolas I, Hall Z, Leslie J, Carobbio S, Virtue S, Davies S, Lukasik A, Dale M, Bohlooly-Y M, Acharjee A, Linden D, Bidault G, Petsalaki E, Griffin J, Oakley F, Allison M, Vidal-Puig | 2021 | Molecular Metabolism | Metabolism | Area Quantification, Cytonuclear, Multiplex IHC | HALO |
An endogenous opioid circuit determines state-dependent appetitive behavior | Castro D, Oswell C, Zhang E, Pedersen C, Piantadosi S, Rossi M, Hunker A, Guglin A, Moron J, Zweifel L, Stuber G, Bruchas M | 2021 | bioRxiv | Neuroscience | Cytonuclear, Highplex FL | HALO |
A faithful in vivo model of human macrophages in metastatic melanoma | Voillet V, Berger T, McKenna K, Paulson K, Smythe K, Hunter D, Valente W, Weaver S, Campbell J, Kim T, Byrd D, Bielas J, Pierce R, Chapuis A, Gottardo R, Rongvaux | 2021 | bioRxiv | Cytonuclear, Multiplex IHC | HALO | |
Maternal platelets pass interstices of trophoblast columns and are not activated by HLA-G in early human pregnancy | Guettler J, Forstner D, Cvirn G, Maninger S, Brugger B Nonn O, Kupper N, Pritz E, Wernitznig S, Dohr G, Hutter H, Juch H, Isermann B, Kohli S, Gauster M | 2021 | Journal of Reproductive Immunology | Other | Cytonuclear, Highplex FL | HALO |
Absolute copy number fitting from shallow whole genome sequencing data | Sauer C, Eldridge M, Vias M, Hall J, Boyle S, Macintyre G, Bradley T, Markowetz F, Brenton J | 2021 | bioRxiv | Oncology | Classifier | HALO |
E3 ligase-inactivation rewires CBL interactome to elicit oncogenesis by hijacking RTKCBLCIN85 axis | Ahmed S, Buetow L, Gabrielsen M, Lilla S, Sibbet G, Sumpton D, Zanivan S, Hedley A, Clark W, Huang D | 2021 | Oncogene | Oncology | Cytonuclear, Multiplex IHC | HALO |
Detection of EpsteinBarr Virus in Periodontitis: A Review of Methodological Approaches | Tonoyan L, Chevalier M, Vincent-Bungnas S, Marsault R, Doglio A | 2021 | Mircroorganisms | Review | ISH/FISH, ISH-IHC/FISH-IF | HALO |
CYRI-A limits invasive migration through macropinosome formation and integrin uptake regulation | Le A, Yelland T, Paul N, Fort L, Nikolaou S, Ismail S, Machesky L | 2021 | Journal of Cell Biology | Other | Cytonuclear, Multiplex IHC | HALO |
Structure of the helicase core of Werner helicase, a key target in microsatellite instability cancers | Newman J, Gavard A, Lieb S, Ravichandran M, Hauer K, Werni P, Geist L, Bottcher J, Engen J, Rumpel K, Samwer M, Petronczki, Gileadi O | 2021 | Life Science Alliance | Oncology | Cytonuclear, Highplex FL | HALO |
In vitro amplification of pathogenic tau conserves disease-specific bioactive characteristics | Xu H, O'Reilly M, Gibbons G, Changolkar L, McBride J, Riddle D, Zhang B, Stieber A, Nirschl J, Kim S, Hoxha K, Brunden K, Schellenberg G, Trojanowski J, Lee V | 2021 | Acta Neuropathologica | Neruoscience | Cytonuclear, Multiplex IHC | HALO |
Cross-linking of T cell to B cell lymphoma by the T cell bispecific antibody CD20-TCB induces IFN?/CXCL10-dependent peripheral T cell recruitment in humanized murine model | Cremasco F, Menietti E, Speziale D, Sam J, Sammicheli S, Richard M, Varol A, Klein C, Umana P, Bacac M, Colombetti S, Perro M | 2021 | PLOS ONE | Oncology | Cytonuclear, Multiplex IHC, Highplex FL | HALO |
Tissue-resident FOLR2+ macrophages associate with tumor-infiltrating CD8+ T cells and with increased survival of breast cancer patients | Ramos, R, Missolo-Koussou Y, Gerber-Ferder Y, Bromley C, Bugatti M, Nunez N, Tosello J, Richer W, Denizeau J, Sedlik C, Caudana P, Kotsias F, Niborski L, Viel S, Bohec M, Lameiras S, Baulande S, Lesage L, Nicolas A, Mesure D, Vincent-Salomon A, Reyal F, Dutertre C, Ginhoux F, Vimeux L, Donnadieu E, Buttard B, Galon J, Zelenay S, Vermi W, Guermonprez P, Piaggio E, Helft J | 2021 | bioRxiv | Immuno-oncology | Cytonuclear, Highplex FL, TMA | HALO |
CCNE1 amplification is synthetic-lethal with PKMYT1 kinase inhibition | Gallo D, Young J, Fourtounis J, Martino G, Alvarez-Quilon A, Bernier C, Duffy N, Papp R, Roulston A, Stocco R, Szychowski J, Veloso A, Alam H, Baruah P, Fortin A, Bowlan J, Chaudhary N, Desjardins J, Dietrich E, Fournier S, Fugere-Desjardins C, de Rugy T, Leclaire M, Liu B, Melo H, Nicolas O, Singhania A, Szilard R, Tkac J, Yin S, Morris S, Zinda M, Marshall C, Duocher D | 2021 | bioRxiv | Other | Cytonuclear, Multiplex IHC | HALO |
MNK inhibition sensitizes KRAS-mutant colorectal cancer to mTORC1 inhibition by reducing eIF4E phosphorylation and c-MYC expression | Knight J, Alexandrou C, Skalka G, Vlahov N, Pennel K, Officer L, Teodosio A, Kanellos G, Gay D, May-Wilson S, Smith E, Najumudeen A, Gilroy K, Ridgway R, Flanagan D, Smith R, McDonald L, MacKay C, Cheasty A, McArthur K, Stanway E, Leach J, Jackstadt R, Waldron J, Campbell A, Vlachogiannis G, Valeri N, Haigis K, Sonenberg N, Proud C, Jones N, Swarbrick M, McKinnon H, Faller W, LeQuense J, Edwards J, Willis A, Bushell M, Sansom O | 2021 | Cancer Discovery | Oncology | Cytonuclear, Highplex FL | HALO |
Computational modeling of tau pathology spread reveals patterns of regional vulnerability and the impact of a genetic risk factor | Cornblath E, Li H, Changolkar C, Zhang B, Brown H, Gathagan R, Olufemi M, Trojanowski J, Bassett D, Lee V, Henderson M | 2021 | Science Advances | Neuroscience | Area Quantification | HALO |
Tau-tubulin kinase 1 phosphorylates TDP-43 at disease-relevant sites and exacerbates TDP-43 pathology | Tian Y, Wang Y, Jablonski A, Hu Y, Sugam J, Koglin M, Stachel S, Zhou H, Uslaner J, Parmentier-Batteur S | 2021 | Neurobiology of Disease | Neuroscience | Area Quantification | HALO |
Pilot study of Tremelimumab with and without cryoablation in patients with metastatic renal cell carcinoma | Campbell M, Matin S, Tam A, Sheth R, Ahrar K, Tidwell R, Rao P, Karam J, Wood C, Tannir N, Jonasch E, Gao J, Zurita A, Shah A, Jindal S, Duan F, Basu S, Chen H, Espejo A, Allison J, Yadav S, Sharma P | 2021 | Nature Communications | Oncology | Cytonuclear | HALO |
Cancer immune therapy with PD-1-dependent CD137 co-stimulation provides localized tumour killing without systemic toxicity | Qiao Y, Qiu Y, Ding J, Luo N, Wang H, Ling X, Sun J, Wu Z, Wang Y, Liu Y, Guo F, Sun T, Shen W, Zhang M, Wu D, Chen B, Xu W, Wang X | 2021 | Nature Communications | Immuno-oncology | Cytonuclear, Multiplex IHC | HALO |
Small molecule inhibitors of ?-synuclein oligomers identified by targeting early dopamine-mediated motor impairment in C. elegans | Chen K, Menezes K, Rodgers J, )'Hara D, Tran N, Fujisawa K, Ishikura S, Khodaei S, Chau H, Cranston A, Kapadia M, Pawar G, Ping S, Krizus A, Lacoste A, Spangler S, Visanji N, Marras C, Majbour N, El-Agnaf O, Lozano A, Culotti, Suo S, Ryu W, Kalia S, Kalia L | 2021 | Molecular Neurodegeneration | Neuroscience | Cytonuclear | HALO |
Intratumoral Heterogeneity and Immune Response Indicators to Predict Overall Survival in a Retrospective Study of HER2-Borderline (IHC 2+) Breast Cancer Patients | Radziuviene G, Rasmusson A, Augulis R, Grineviciute R, Zilenaite D, Laurinaviciene A, Ostapenko V, Laurinavicius A | 2021 | Frontiers in Oncology | Immuno-oncology | Membrane, Multiplex IHC | HALO AI |
The TRPA1 Channel Amplifies the Oxidative Stress Signal in Melanoma | De Logu F, Monteiro de Araujo D, Ugolini F, Iannone L, Vannucchi M, Portelli F, Landini L, Titiz M, De Giorgi V, Geppetti P, Massi D, Nassini R | 2021 | Cells | Area Quantification, Multiplex IHC | HALO, HALO Link, HALO AI | |
CD98-induced CD147 signaling stabilizes the Foxp3 protein to maintain tissue homeostasis | Geng J, Chen R, Yang F, Lin P, Zhu Y, Fu X, Wang K, Feng Z, Wu J, Zhang H, Li Q, Chen Z, Zhu P | 2021 | Cellular and Molecular Immunology | Immuno-oncology | Cytonuclear, Highplex FL | HALO |
Immune Response in Myocardial Injury: In Situ Hybridization and Immunohistochemistry Techniques for SARS-CoV-2 Detection in COVID-19 Autopsies | Chong P, Iqbal J, Yeong J, Aw T, Chan K, Chui P | 2021 | Frontiers in Molecular Biosciences | Infectious Disease | HALO | |
STING regulates peripheral nerve regeneration and colony stimulating factor 1 receptor (CSF1R) processing in microglia | Morozzi G, Rothen J, Toussaint G, De Lange K, Westritschnig K, Doelemeyer A, Ueberschlag V, Kahle P, Lambert C, Obrecht M, Beckmann N, Ritter V, Panesar M, Stauffer D, Garnier I, Mueller M, Guerini D, Keller C, Knehr J, Roma G, Bidinosti M, Brachat S, Morvan F, Forano M | 2021 | iScience | Neuroscience | Cytonuclear | HALO AI |
Deleting DNMT3A in CAR T cells prevents exhaustion and enhances antitumor activity | Prinzing B, Zebley C, Petersen C, Fan Y, Anido A, Yi Z, Nguyen P, Houke H, Bell M, Haydar D, Brown C, Boi S, Alli S, Crawford J, Riberdy J, Park J, Zhou S, Velasquez M, DeRenzo C, Lazzarotto C, Tsai S, Vogel P, Pruett-Miller S, Langfitt D, Gottschalk S, Youngblood B, Krenciute G | 2021 | Science Translational Medicine | Immuno-oncology | Cytonuclear | HALO |
Isoform specific anti-TGF? therapy enhances antitumor efficacy in mouse models of cancer | Gupta A, Budhu S, Fitzgerald K, Giese R, Michel A, Holland A, Campesato L, vanSnick J, Uyttenhove C, Ritter G, Wolchok J, Merghoub T | 2021 | Communications Biology | Oncology | Area Quantification | HALO |
Inhibitory effects and mechanisms of the anti-covid-19 traditional Chinese prescription, Keguan-1, on acute lung injury | Bai, Z, Li P, Wen J, Han Y, Cui Y, Zhou Y, Shi Z, Chen S, Li Q, Zhao X, Wang Z, Li R, Guo Y, Zhan X, Xu G, Ding K, Wang J, Xiao X | 2021 | Journal of Ethnopharmacology | Infectious Disease | Highplex FL | HALO |
Soluble guanylate cyclase signalling mediates etoposide resistance in progressing small cell lung cancer | Schenk M, Humprey S, Hossain A, Revill M, Pearsall S, Lallo A, Brown S, Bratt S, Galvin M, Descamps T, Zhou C, Pearce S, Priest L, Greenhalgh M, Chaturvedi A, Kerr A, Blackhall F, Dive C, Frese K | 2021 | Nature Communications | Oncology | Classifier, Area Quantification | HALO |
Spatial mapping of protein composition and tissue organization: a primer for multiplexed antibody-based imaging | Hickey J, Neumann E, Radtke A, Camarillo J, Beuschel R, Albanese A McDonough E, Hatler J, Wiblin A, Fisher J, Croteau J, Small E, Sood A, Caprioli R, Angelo R. Nolan G, Chung K, Hewitt S, Germain R, Spraggins J, Lundberg E, Snyder M, Kelleher N, Saka S | 2021 | Nature Methods | Review | HALO | |
Alpha-synuclein from patient Lewy bodies exhibits distinct pathological activity that can be propagated in vitro | Marotta N, Ara J, Uemura N, Lougee M, Meymand E, Zhang B, Petersson E, Trojanowski J, Lee V | 2021 | Acta Neuropathologica Communications | Neuroscience | HALO | |
Advances in mass cytometry and its applicability to digital pathology in clinical-translational cancer research | Cereceda K, Jorquera R, Villarroel-Espindola, F | 2021 | Advances in Laboratory Medicine | Review | HALO | |
Immuno-transcriptomic profiling of extracranial pediatric solid malignancies | Brohl A, Sindiri S, Wei J, Milewski D, Chou H, Song Y, Wen X, Kumar J, Reardon H, Mudunuri U, Collins J, Nagaraj S, Gangalapudi V, Tyagi M, Zhu Y, Masih K, Yohe M, Shern J, Qi Y, Turpin B, Leino D, Iwata S, Andrulis I, Wunder J, Toledo S, Meltzer P, Lau C, Teicher B, Magnan H, Ladanyi M, Khan J | 2021 | Cell Reports | Oncology | HALO | |
*Immune cell topography predicts response to PD-1 blockade in cutaneous T cell lymphoma | Phillips D, Matusiak M, Gutierrez BR, Bhate SS, Barlow GL, Jiang S, Demeter J, Smythe KS, Pierce RH, Fling SP, Ramchurren N, Cheever MA, Goltsev Y, West RB, Khodadoust MS, Kim YH, Schürch CM, Nolan GP | 2021 | Nature Communications | Immuno-oncology | HALO | |
A single cell atlas reveals distinct immune landscapes in transplant and primary tumors that determine response or resistance to immunotherapy | Wisdom AJ, Mowery YM, Hong CS, Qin X, Zhang D, Himes JE, Chen L, Fradin H, Muise ES, Xu ES, Carpenter DJ, Kent CL, Smythe KS, Williams N, Luo L, Ma Y, Owzar K, Bradley T, Kirsch DG | 2020 | Nature Communications | Oncology, Immuno-oncology | Cytonuclear | HALO |
Spatial Clustering of CD68+ Tumor Associated Macrophages with Tumor Cells is Associated with Worse Overall Survival in Metastatic Clear Cell Renal Cell Carcinoma | Chakiryan NH, Kimmel GJ, Kim Y, Hajiran A, Aydin AM, Zemp L, Katende E, Nguyen J, Lopez-Blanco N, Chahoud J, Spiess PE, Fournier M, Dhillon J, Wang L, Moran-Segura C, El-Kenawi A, Mulé J, Altrock PM, Manley BJ | 2021 | PLOS ONE | Immuno-oncology | Highplex FL | HALO |
A Deep Learning Approach for Tissue Spatial Quantification and Genomic Correlations of Histopathological Images | Lu Z, Zhan X, Wu Y, Chng J, Shao W, Ni D, Han Z, Zhang J, Feng Q, Huang K | 2020 | Genomics, Proteomics & Bioinformatics | Review | HALO | |
CD117/c-kit Defines a Prostate CSC-Like Subpopulation Driving Progression and TKI Resistance | Koran S. Harris, Shi L, Foster BM, Mobley ME, Elliott PL, Song CJ, Watabe K, Langefeld CD, Kerr BA | 2020 | Scientific Reports | Oncology | HALO | |
Localization of KRAS downstream target ARL4C to invasive pseudopods accelerates pancreatic cancer cell invasion | Harada A, Matsumoto S, Yasumizu Y, Akama T, Eguchi H, Kikuchi A | 2021 | bioRxiv | Oncology | Area Quantification | HALO |
ABCF1 regulates dsDNA-induced immune responses in human airway epithelial cells | Cao QT, Aguiar JA, Tremblay BJ-M, Abbas N, Tiessen N, Revill S, Makhdami N, Ayoub A, Cox G, Ask K, Doxey AC, Hirota JA | 2020 | Frontiers in Cellular and Infection Microbiology | Immunology | HALO | |
Accelerated phosphatidylcholine turnover in macrophages promotes adipose tissue inflammation in obesity | Petkevicius K, Virtue S, Bidault G, Jenkins B, Cubuk C, Morgantini C, Aouadi M, Dopazo J, Serlie M, Koulman A, Vidal-Puig A | 2019 | Elife | Classifier, Vacuole | HALO | |
Bone Morphogenetic Protein Pathway Antagonism by Grem1 Regulates Epithelial Cell Fate in Intestinal Regeneration | Koppens MAJ, Davis H, Valbuena GN, Mulholland EJ, Nasreddin N, Colombe M, Antanaviciute A, Biswas S, Friedrich M, Lee L, Oxford IBD cohort investigators, Wang LM, Koelzer VH, East JE, Simmons A, Winton DJ, Leedham SJ | 2021 | Gastroenterology | Gastroenterology | Area Quantification | HALO |
Two distinct immunopathological profiles in autopsy lungs of COVID-19 | Nienhold R, Ciani Y, Koelzer V, Tzankov A, Haslbauer J, Menter T, Schwab N, Henkel M, Frank A, Zsikla V, Willi N, Kempf W, Hoyler T, Barbareschi M, Moch H, Tolnay M, Cathomas G, Dernichelis F, Junt T, Mertz K | 2021 | Nature Communications | Infectious Disease | Multiplex IHC | HALO AI |
Effects of advanced age upon astrocyte-specific responses to acute traumatic brain injury in mice | Early AN, Gorman AA, Van Eldik LJ, Bachstetter AD, Morganti JM | 2019 | Journal of Neuroinflammation | Neuroscience | Area Quantification | HALO |
FK506-binding protein 13 expression is upregulated in interstitial lung disease and correlated with clinical severity: a potentially protective role | Tat V, Ayaub EA, Ayoub A, Vierhout M, Naiel S, Padwal MK, Abed S, Mekhael O, Tandon K, Revill SD, Yousof T, Bellaye PS, Kolb PS, Dvorkin-Gheva A, Naqvi A, Cutz JC , Hambly N, Kato J, Vaughan M, Moss J, Kolb MRJ, Ask K | 2019 | American Journal of Respiratory Cell and Molecular Biology | Immunology, Fibrosis | Area Quantification, Cytonuclear | HALO |
Integrated human pseudoislet system and microfluidic platform demonstrate differences in GPCR signaling in islet cells | Walker JT, Haliyur R, Nelson HA, Ishahak M, Poffenberger G, Aramandla R, Reihsmann C, Luchsinger JR, Saunders DC, Wang P, Garcia-Ocana A, Bottino R, Agarwal A, Powers AC, Brissove M | 2019 | bioRxiv | Gastroenterology | Cytonuclear | HALO |
Detection of engineered T cells in FFPE tissue by multiplex in situ hybridization and immunohistochemistry | Wright JH, Huang L-Y, Weaver S, Archila LD, McAfee MS, Hirayama AV, Chapuis AG, Bleakley M, Rongvaux A, Turtle CJ, Chanthaphavong S, Campbell JS, Pierce RH | 2020 | Journal of Immunological Methods | Immunology | ISH/FISH, ISH-IHC/FISH-IF | HALO |
Mesenchyme-derived IGF2 is a major paracrine regulator of pancreatic growth and function | Hammerle CM, Sandovici I, Brierley GV, Smith NM, Zimmer WE, Zvetkova I, Prosser HM, Sekita Y, Lam BYH, Ma M, Cooper WN, Vidal-Puig A, Ozanne SE, Medina-Gomez G, Constancia M | 2020 | PLOS Genetics | Toxicology | Area Quantification | HALO AI |
Microbial regulation of enteric eosinophils and its impact on tissue remodeling and Th2 immunity | Jimenez-Saiz R, Anipindi VC, Galipeau H, Ellenbogen Y, Chaudhary R, Koenig JF, Gordon ME, Walker TD, Mandur TS, Abed S, Humbles A, Chu DK, Ask K, Verdu EF, Jordana M | 2019 | Frontiers in Immunology | Immunology, Infectious Disease | Area Quantification | HALO |
Distinct fibroblast functional states drive clinical outcomes in ovarian cancer and are regulated by TCF21 | Hussain A, Voisin V, Poon S, Dmytryshyn J ,Richman C, Meens J, Ho VW, Tang KH, Paterson J, Clarke B, Bernardini M, Bader G, Neel B, Ailles L | 2019 | Journal of Experimental Medicine | Oncology | Classifier, Area Quantification | HALO |
Transcriptomic analysis links diverse hypothalamic cell types to fibroblast growth factor 1-induced sustained diabetes remission | Bentsen MA, Rausch DM, Mirzadeh Z, Muta K, Scarlett JM, Brown JM, Herranz-Perez V, Baquero AF, Thompson J, Alonge KM, Faber CL, Kaiyala KJ, Bennett C, Pyke C, Ratner C, Egerod KL, Holst B, Meek TH, Kutlu B, Zhang Y, Sparso T, Grove KL, Morton GJ, Kornum BR, Garcia-Verdugo J-M, Secher A, Jorgensen R, Schwartz MW, Pers TH | 2020 | Nature Communications | Metabolism | ISH/FISH | HALO |
PPAR-gamma induced AKT3 expression increases levels of mitochondrial biogenesis driving prostate cancer | Galbraith L, Mui E, Nixon C, Hedley A, Strachan D, MacKay G, Sumpton D, Sansom O, Leung H, Ahmad I | 2021 | Oncogene | Oncology | ISH/FISH | HALO |
Pixelwise H-score: a novel digital image analysis-based metric to quantify membrane biomarker expression from immunohistochemistry images | Ram S, Vizcarra P, Whalen P, Deng S, Painter C, Jackson-Fisher A, Pirie-Shepherd S, Xia X, Powell E | 2021 | PLOS One | Other | Cytonuclear, Multiplex IHC | HALO |
EHF is essential for epidermal and colonic epithelial homeostasis and suppresses Apc-initiated colonic tumorigenesis | Reehorst C, Nightingale R, Luk I, Jenkins L, Koentgen F, Williams D, Darido C, Tan F, Anderton H, Chopin M, Schoffer K, Eissmann M, Buchert M, Mouradov D, Sieber O, Ernst M, Dhillon A, Maridason J | 2021 | Development | Oncology | Cytonuclear, Highplex FL | HALO |
LRPPRC regulates redox homeostasis via the circANKHD1/FOXM1 axis to enhance bladder urothelial carcinoma tumorigenesis | Wei W, Wang N, Deng M, Dong P, Liu J, Xiang Z, Li X, Li Z, Liu Z, Peng Y, Li Z, Jiang L, Yao K, Ye Y, Lu W, Zhang Z, Zhou F, Liu Z, Xie D, Yu C | 2021 | Redox Biology | Metabolism | Cytonuclear, Multiplex IHC | HALO |
A growth factorexpressing macrophage subpopulation orchestrates regenerative inflammation via GDF-15 | Patsalos A, Halasz L, Medina-Serpas M, Berger W, Daniel B, Tzerpos P, Kiss M, Nagy G, Fischer C, Simandi Z, Varga T, Nagy L | 2021 | Journal of Experimental Medicine | Muscle Fiber | HALO | |
Antiretroviral therapy timing impacts latent tuberculosis infection reactivation in a tuberculosis/simian immunodeficiency virus coinfection model | Sharan R, Ganatra S, Bucsan A, Cole J, Singh D, Alvarez X, Gough M, Alvarez C, Blakley A, Ferdin J, Thippeshappa R, Singh B, Escobedo R, Shivanna V, Dick E, Hall-Ursone S, Khader S, Mehra S, Rengarajan J, Kaushal D | 2021 | The Journal of Clinical Investigation | Infectious Disease | Cytonuclear, Highplex FL | HALO |
Effects of Dietary Pork Fat Cooked Using Different Methods on Glucose and Lipid Metabolism, Liver Inflammation and Gut Microbiota in Rats | Zhu W, Xu Y, Liu J, Chen D, Zhang H, Yang Z, Zhou X | 2021 | Foods | Metabolism | Area Quantification | HALO |
Low immunogenicity of LNP allows repeated administrations of CRISPR-Cas9 mRNA into skeletal muscle in mice | Kenjo E, Hozumi H, Makita Y, Iwabuchi K, Fujimoto N, Matsumoto S, Kimura M, Amano Y, Ifuku M, Naoe Y, Inukai N, Hotta A | 2021 | Nature Communications | Other | Muscle Fiber | HALO |
Comprehensive clinicopathologic study of alpha fetoprotein-expression in a large cohort of patients with hepatocellular carcinoma | Ridder D, Weinmann A, Schindeldecker M, Urbansky L, Berndt K, Gerber T, Lang H, Lotz J, Lackner K, Roth W, Straub B | 2021 | International Journal of Cancer | Oncology | Cytonuclear, TMA | HALO |
Nuclear pore protein NUP210 depletion suppresses metastasis through heterochromatin-mediated disruption of tumor cell mechanical response | Amin R, Shukla A, Zhu J, Kim S, Wang P, Tian S, Tran A, Paul D, Cappell S, Burkett S, Liu H, Lee M, Kruhlak M, Dwyer J, Simpson R, Hager G, Ruan Y, Hunter K | 2021 | Nature Communications | Oncology | Area Quantification | HALO AI |
Inter-organ transmission of hepatocellular senescence induces multi-organ dysfunction through the TGF? signalling pathway | Kiourtis C, Terradas-Terradas M, Gee L, Hsieh Y, Nixon C, Clark W, Shaw R, Hanson P, Sumpton D, Mackay G, May S, Muller M, Najumudeen A, Campbell A, Barry S, Morris C, LeBeau F, Sansom O, Kirschner K, Oakley F, Bird T | 2021 | Research Square | Other | Area Quantification, Cytonuclear, Multiplex IHC | HALO |
Hedgehog-signalling in papillary fibroblasts is essential for hair follicle regeneration during wound healing | Frech S, Forsthuber A, Korosec A, Lipp K, Kozumov V, Lichtenberger B | 2021 | Journal of Investigative Dermatology | Dermatology | Cytonuclear, Multiplex IHC | HALO |
Heterocellular OSM-OSMR signalling reprograms fibroblasts to promote pancreatic cancer growth and metastasis | Lee B, Hogg E, Below C, Kononov A, Blanco-Gomez A, Heider F, Xu J, Hutton C, Zhang X, Scheidt T, Beattie K, Lamarca A, McNamara M, Valle J, Jorgensen C | 2021 | Nature Communications | Oncology | Classifier, Area Quantification | HALO |
Evaluation of Early Markers of Ischemia-reperfusion Injury and Preservation Solutions in a Modified Hindlimb Model of Vascularized Composite Allotransplantation | Rostami S, Xu M, Datta S, Haykal S | 2022 | Transplantation Direct | Cytonuclear, Multiplex IHC | HALO | |
B7-1 and programmed cell death-ligand 1 in primary and lymph node metastasis lesions of non-small cell lung carcinoma | Yamada T, Miki Y, Suzuki M, Kondoh O, Saito-Koyama R, Ono K, Okada Y, Sasano H | 2021 | Cancer Medicine | Oncology | Cytonuclear, Multiplex IHC | HALO |
A minimal standardized human bone marrow microphysiological system to assess resident cell behavior during normal and pathological processes | Voeltzel T, Fossard G, Degaud M, Geistlich K, Gadot N, Jeanpierre S, Mikaelian I, Brevet M, Anginot A, Le Bousse-Kerdiles M, Trichet V, Lefort S, Maguer-Satta V | 2021 | Biomaterials Science | Biomaterials | Area Quantification, Cytonuclear | HALO |
Effect of Electroacupuncture at Siguan Acupoints on Expression of BDNF and TrkB Proteins in the Hippocampus of Post-Stroke Depression Rats | Kang Z, Ye H, Chen T, et al. | 2021 | Journal of Molecular Neuroscience | Neuroscience | HALO | |
An ex vivo tumor fragment platform to dissect response to PD-1 blockade in cancer | Voabil P, de Bruijn M, Roelofsen L, Hendriks S, Brokamp S, van den Braber M, Broeks A, Sanders J, Herzig P, Zippelius A, Blank C, Hartemink K, Monkhorst K, Haanen J, Schumacher T, Thommen D | 2021 | Nature Medicine | Immuno-oncology | Classifier, Multiplex IHC, | HALO |
Computational pathology reveals unique spatial patterns of immune response in H&E images from COVID-19 autopsies: preliminary findings | Corredor G, Toro P, Bera K, Rasmussen D, Viswanathan V, Buzzy C, Fu P, Barton L, Stroberg E, Duval E, Gilmore H, Mukhopadhyay, Madabhushi A | 2021 | Journal of Medical Imaging | Infectious Disease | HALO Link | |
Anti-CD47 antibody administration via cisterna magna in proper dosage can reduce perihematomal cell death following intracerebral hemorrhage in rats | Song Y, Wang H, Li F, Huang Q, Zhang Z | 2021 | Brain Research Bulletin | Other | Highplex FL | HALO |
Investigation of Breast Cancer Microstructure and Microvasculature from Time-Dependent DWI and CEST in Correlation with Histological Biomarkers | Someya Y, Iima M, Imai H, Yoshizawa A, Kataoka M, Isoda H, Le Bihan D, Nakamoto Y | 2021 | Research Square | Classifier, Multiplex IHC | HALO | |
Secretory pathway Ca-ATPase2 (SPCA2) gene knockout results in mouse mammary gland changes and a secretory defect | Reinhardt T, Lippolis J, Palmer M | 2021 | Research Square | Other | HALO | |
Specificity and off-target effects of AAV8-TBG viral vectors for the manipulation of hepatocellular gene expression in mice | Kiourtis C, Wilczynska A, Nixon C, Clark W, May S, Bird T | 2021 | Biology Open | Other | Multiplex IHC | HALO |
Cross-Platform Comparison of Computer-assisted Image Analysis Quantification of In Situ mRNA Hybridization in Investigative Pathology | Holzer TR, Hanson JC, Wray EM, Bailey JA, Kennedy KR, Finnegan PR, Nasir A, Credille KM | 2019 | Applied Immunohistochemistry & Molecular Morpholgy | Other | ISH/FISH | HALO |
The SGLT2i Dapagliflozin Reduces RV Hypertrophy Independent of Changes in RV Pressure Induced by Pulmonary Artery Banding | Connelly K, Wu E, Visram A, Friedberg M, Batchu S, Yeera V, Thai K, Nghiem L, Zhang Y, Kabir G, Desjardins J, Advani A, Gilbert R | 2021 | Research Square | Other | Area Quantification | HALO |
spatialTIME and iTIME: R package and Shiny application for visualization and analysis of immunofluorescence data | Creed J, Wilson C, Soupir A, Colin-Leitzinger C, Kimmel G, Ospina O, Chakiryan N, Markowitz J, Peres L, Coghill A, Fridley B | 2021 | Bioinformatics | Other | Classifier, Cytonuclear, Highplex FL | HALO |
Local radiotherapy and E7 RNA-LPX vaccination show enhanced therapeutic efficacy in preclinical models of HPV16+ cancer | Salomon N, Selmi A, Grunwitz C, Kong A, Stanganello E, Neumaier J, Petschenka J, Diken M, Kreiter S, Tureci O, Sahin U, Vascotto F | 2021 | Cancer Immunology, Immunotherapy | Oncology, Infectious Disease | Highplex FL | HALO |
Clinically relevant mitochondrial-targeted therapy improves chronic outcomes after traumatic brain injury | Hubbard W, Spry M, Gooch J, Cloud A, Vekaria H, Burden S, Powell D, Berkowitz B, Geldenhuys W, Harris N, Sullivan P | 2021 | Brain | Neuroscience | Area Quantification | HALO |
Anti-CAIX BB? CAR4/8 T Cells Exhibit Superior Efficacy in a Clear Cell Renal Cell Carcinoma (ccRCC) Mouse Model | Wang Y, Buck A, Grimaud M, Culhane A, Kodangattil S, Razimbaud C, Bonal D, Nguyen Q, Zhu Z, Wei K, O'Donnell M, Huang Y, Signoretti S, Choueiri T, Freeman G, Zhu Q, Marasco | 2021 | Molecular Therapy: Oncolytics | Oncology | Cytonuclear, Multiplex IHC | HALO |
The microglial P2Y6 receptor mediates neuronal loss and memory deficits in neurodegeneration | Puigdellivol M, Milde S, Vilalta A, Cockram T, Allendorf D, Lee J, Dundee J, Pampuscenko K, Borutaite V, Nuthall H, Brelstaff J, Spillantini G, Brown G | 2021 | Cell Reports | Neuroscience | Area Quantification, Cytonuclear, Multiplex IHC | HALO |
Cannabinoid control of gingival immune activation in chronically SIV-infected rhesus macaques involves modulation of the indoleamine-2,3-dioxygenase-1 pathway and salivary microbiome | McDew-White M, Lee E, Alvarez X, Sestak K, Ling B, Byrareddy S, Okeoma C, Mohan M | 2022 | EBioMedicine | Infectious Disease | Area Quantification, Cytonuclear, Highplex FL | HALO |
Neoadjuvant immunotherapy with nivolumab and ipilimumab induces major pathological responses in patients with head and neck squamous cell carcinoma | Vos J, Elbers J, Krijgsman O, Traets J, Qiao X, van der Leun A, Lubeck Y, Seignette I, Smit L, Willems S, van den Brekel M, Dirven R, Karakullukcu B, Karssemakers L, Klop W, Lohuis P, Schreuder W, Smeele L, van der Velden L, Tan I, Onderwater S, Jasperse B, Vogel W, Al-Mamgani A, Keijser A, van der Noort V, Broeks A, Hooijberg E, Peeper D, Schumacher T, Blank C, de Boer J, Haanen J, Zuur C | 2021 | Nature Communications | Oncology | Classifier, Highplex FL | HALO |
ACE2-IgG1 fusions with improved in vitro and in vivo activity against SARS-CoV-2 | Iwanaga N, Cooper L, Rong L, Maness N, Beddingfield B, Qin Z, Crabtree J, Tripp R, Yang H, Blair R, Jangra S, Garcia-Sastre A, Schotsaert M, Chandra S, Robinson J, Srivastava A, Rabito F, Qin X, Kolls J | 2022 | iScience | Infectious Disease | Highplex FL | HALO AI |
Tumor MHC Class I Expression Associates with Intralesional Interleukin-2 Response in Melanoma | Pourmaleki M, Jones C, Ariyan C, Zeng Z, Pirun M, Navarrete D, Li Y, Zhang M, Nandakumar S, Campos C, Nadeem S, Klimstra D, Temple-Oberle C, Brenn T, Kipson E, Schenk K, Stein J, Taube J, White M, Traweek R, Wargo J, Kirkwood J, Gasmi B, Goff S, Corwin A, McDonough E, Ginty F, Callahan M, Schietinger A, Socci N, Mellinghoff I, Hollmann T | 2022 | Cancer Research Immunology | Immuno-oncology | Highplex FL | HALO |
Progranulin mediates immune evasion of pancreatic ductal adenocarcinoma through regulation of MHCI expression | Cheung P, Yang J, Fang R, Borgers A, Krengel K, Stoffel A, Althoff K, Yip C, Siu E, Ng L, Lang K, Cham L, Engel D, Soun C, Cima I, Scheffler B, Striefler J, Sinn M, Bahra M, Pelzer U, Oettle H, Markus P, Smeets E, Aarntzen E, Savvatakis K, Liffers S, Lueong S, Neander C, Bazarna A, Zhang X, Paschen A, Crawford H, Chan A, Cheung S, Siveke J | 2022 | Nature Communications | Oncology | Cytonuclear, Spatial Analysis, Highplex FL | HALO |
Tumor cell-derived exosomes deliver TIE2 protein to macrophages to promote angiogenesis in cervical cancer | Du S, Qian J, Tan S, Li W, Liu P, Zhao J, Zeng Y, Xu L, Wang Z, Cai J | 2022 | Cancer Letters | Oncology | Area Quantification, Cytonuclear, Spatial Analysis, Highplex FL | HALO |
Understanding the impact of chemotherapy on the immune landscape of high-grade serous ovarian cancer | Vanguri R, Benhamida J, Young J, Li Y, Zivanovic O, Chi D, Snyder A, Hollmann T, Mager K | 2022 | Gynecologic Oncology Reports | Oncology | Classifier, Cytonuclear, Highplex FL | HALO |
Landscape of cancer-associated fibroblasts identifies the secreted biglycan as a protumor and immunosuppressive factor in triple-negative breast cancer | Zheng S, Zou Y, Tang Y, Yang A, Liang J, Wu L, Tian W, Xiao W, Xie X, Yang L, Xie J, Wei W, Xie X | 2022 | OncoImmunology | Immuno-oncology | Cytonuclear, Multiplex IHC | HALO |
The Tumor Immune Landscape and Architecture of Tertiary Lymphoid Structures in Urothelial Cancer | van Dijk N, Gil-Himenez A, Silina K, van Montfoort M, Einerhand S, Jonkman L, Voskuilen C, Peters D, Sanders J, Lubeck Y, Broeks A, Hooijberg E, Vis D, van den Broek M, Wessels L, van Rhijn B, van der Heijden M | 2021 | Frontiers in Immunology | Immuno-oncology | Cytonuclear, Spatial Analysis, Highplex FL | HALO AI |
Postmortem high-dimensional immune profiling of severe COVID-19 patients reveals distinct patterns of immunosuppression and immunoactivation | Wu H, He P, Ren Y, Xiao S, Wang W, Liu Z, Li H, Wang Z, Zhang D, Cai J, Zhou X, Jiang D, Fei X, Zhao L, Zhang H, Liu Z, Chen R, Li W, Wang C, Zhang S, Qin J, Nasan B, Sun C | 2022 | Nature Communications | Infectious Disease | Multiplex IHC | HALO |
EBV+ tumors exploit tumor cell-intrinsic and -extrinsic mechanisms to produce regulatory T cell-recruiting chemokines CCL17 and CCL22 | Jorapur A, Marshall L, Jacobson S, Xu M, Marubayashi S, Zibinsky M, Hu D, Robles O, Jackson J, Baloche V, Busson P, Wustrow D, Brockstedt D, Talay O, Kassner P, Cutler G | 2022 | PLOS Pathogens | Oncology | ISH/FISH | HALO |
AAV9/MFSD8 gene therapy is effective in preclinical models of neuronal ceroid lipofuscinosis type 7 disease | Chen X, Dong T, Hu Y, Shaffo F, Belur N, Mazzulli J, Gray S | 2022 | The Journal of Clinical Investigation | Neuroscience | Area Quantification, ISH/FISH | HALO |
Transcription factor Mesenchyme Homeobox Protein 2 (MEOX2) modulates nociceptor function | Kokotovic T, Lenartowicz E, Langeslag M, Ciotu C, Fell C, Scaramuzza A, Fischer M, Kress M, Penninger J, Nagy V | 2022 | The FEBS Journal | Neruoscience | Multiplex IHC | HALO |
Collaborative workflow between pathologists and deep learning for evaluation of tumor cellularity in lung adenocarcinoma | Sakamoto T, Furukawa T, Pham H, Kuroda K, Tabata K, Kshima Y, Okoshi E, Morimoti S, Bychkov A, Fukuoka J | 2022 | bioRxiv | Oncology | Cytonuclear, Multiplex IHC | HALO AI |
Switching to Regular Diet Partially Resolves Liver Fibrosis Induced by High-Fat, High-Cholesterol Diet in Mice | Farooq M, Hameed H, Dimanchi-Boitrel M, Piquet-Pellorce C, Samson M, Le Seyec J | 2022 | Nutrients | Metabolism | Area Quantification | HALO |
T cell-mediated anti-tumor immunity cooperatively induced by TGF?R1 antagonism and gemcitabine counteracts reformation of the stromal barrier in pancreatic cancer | Li D, Schaub N, Guerin T, Bapiro T, Richards F, Chen V, Talsania K, Kumar P, Gilbert D, Scholmer J, Kim S, Sorber R, Teper Y, Bautista W, Palena C, Ock C, Jodrell D, Pate N, Mehta M, Zhao Y, Kozlov S, Rudloff U | 2021 | Molecular Cancer Therapeutics | Immuno-oncology | Highplex FL | HALO |
Genome Sequence and Experimental Infection of Calves with Bovine Gammaherpesvirus 4 (BoHV-4) | Bauermann F, Falkenberg S, Martins M, Dassanayake R, Neill J, Ridpath J, Silveira S, Palmer M, Buysse A, Mohr A, Flores E, Diel D | 2022 | Research Square | Infectious Disease, Other | ISH/FISH | HALO |
New Fully Automated Preparation of High Apparent Molar Activity 68Ga-FAPI-46 on a Trasis AiO Platform | Da Pieve C, Braga M, Turton D, Valla F, Cakmak P, Plate K, Kramer-Marek G | 2022 | Molecules | Other | Cytonuclear, Highplex FL | HALO |
Retrospective analysis of the efficacy of adjuvant cytokine-induced killer cell immunotherapy combined with chemotherapy in colorectal cancer patients after surgery | Li X, Zhou H, Huang W, Wang X, Meng M, Hou Z, Liao L, Tang W, Xie Y, Wang R, Yu H, Wang L, Zhu H, Wang W, Tan J, Li R | 2022 | Clinical & Translational Immunology | Oncology | Cytonuclear, Highplex FL | HALO |
Fasting improves therapeutic response in hepatocellular carcinoma through p53-dependent metabolic synergism | Krstic J, Reinisch I, Schindlmaier K, Galhuber M, Riahi Z, Berger N, Kupper N, Moyschewitz E, Auer M, Michenthaler H, Nossing C, Repaoli M, Ramadani-Muja J, Usluer S, Stryeck S, Pichler M, Rinner B, Deutsch A, Reinisch A, Madl T, Chiozzi R, Heck A, Huch M, Malli R, Prokesch | 2022 | Science Advances | Oncology | Classifier | HALO |
GPNMB expression identifies TSC1/2/mTOR-associated and MiT family translocation-driven renal neoplasms | Salles D, Asrani K, Woo J, Vidotto T, Liu H, Vidal I, Matoso A, Netto G, Argani P, Lotan T | 2022 | The Journal of Pathology | Oncology | Membrane | HALO |
High-dose rifampin improves bactericidal activity without increased intracerebral inflammation in animal models of tuberculous meningitis | Ruiz-Bedoya C, Mota F, Tucker E, Mahmud F, Reyes-Mantilla M, Erice C, Bahr M, Flavahan K, De Jesus P, Kim J, Foss C, Peloquin C, Hammound D, Ordonez A, Pardo C, Jain S | 2022 | The Journal of Clinical Investigation | Infectious Disease | Area Quanitification | HALO |
Evaluation of a PEGylated Fibroblast Growth Factor 21 Variant Using Novel Preclinical Magnetic Resonance Imaging and Magnetic Resonance Elastography in a Mouse Model of Nonalcoholic Steatohepatitis | Tang H, Li J, Zinker B, Boehm S, Mauer A, Rex-Rabe S, Glaser K, Fronheiser M, Bradstreet T, Nakao Y, Petrone T, Pena A, Villano M, Chow P, Malhi H, Charles E, Hayes W, Ehman R, Du S, Yin M | 2022 | Journal of Magnetic Resonance Imaging | Metabolism | Vacuole | HALO |
Therapeutic treatment with the anti-inflammatory drug candidate MW151 may partially reduce memory impairment and normalizes hippocampal metabolic markers in a mouse model of comorbid amyloid and vascular pathology | Braun D, Powell D, McLouth C, Roy S, Watterson D, Van Eldik | 2022 | PLOS One | Neruoscience | Classifier, Area Quantification | HALO |
African-Ancestry Associated Gene Expression Signatures and Pathways in Triple Negative Breast Cancer, a Comparison across Women of African Descent | Martini R, Delpe P, Chu T, Arora K, Lord B, Verma A, Chen Y, Gebregzabher, Oppong J, Adjei E, Jibril A, Awuah B, Bekele M, Abebe E, Kyei I, Aitpillah F, Adinku M, Ankomah K, Osei-Bonsu E, Chitale D, Bensenhaver J, Nathanson S, Jackson L, Jiagge E, Petersen L, Proctor E, Gyan K, Gibbs L, Monojlovic Z, Kittles R, White J, Yates C, Manne U, Gardner K, Mongan N, Cheng E, Ginter P, Hoda S, Elemento O, Robine N, Sboner A, Carpten J, Newman L, Davis M | 2022 | medRxiv | Oncology | Mulitplex IHC, Serial Section | HALO |
A selective and orally bioavailable VHL-recruiting PROTAC achieves SMARCA2 degradation in vivo | Kofink C, Trainor N, Mair B, Wrhrle S, Wurm M, Mischerikow N, Bader G, Rumpel K, Gerstberger T, Cui Y, Greb P, Garavel G, Scharnweber M, Fuchs J, Gremel G, Chette P, Hopf S, Budano N, Rinnenthal J, Gmaschitz G, Diers E, McLennan R, Roy M, Whitworth C, Vetma V, Mayer M, Koegl M, Ciulli A, Weinstabl H, Farnaby W | 2022 | Biological and Medicinal Chemistry | Classifier, Cytonuclear, Multiplex IHC | HALO | |
Obesity due to Steroid Receptor Coactivator-1 deficiency is associated with endocrine and metabolic abnormalities | Cacciottolo T, Henning E, Keogh J, Lassen P, Lawler K, Bounds R, Ahmed R, Perdikari A, Mendes de Oliverira E, Smith M, Godfrey E, Johnson E, Hodson L, Clement K, van der Klaauw A, Farooqi I | 2022 | The Journal of Clinical Endocrinology & Metabolism | Metabolism | Vacuole | HALO |
Intratumoural spatial distribution of S100B?+?folliculostellate cells is associated with proliferation and expression of FSH and ER? in gonadotroph tumours | Ilie M, Vasiljevic A, Chanal M, Gadot N, Chinezu L, Jouanneau E, Hennino A, Raverot G, Bertolino P | 2022 | Acta Neuropathologica Communications | Oncology | Cytonuclear, Spatial Analysis | HALO |
High-Field Asymmetric Waveform Ion Mobility Spectrometry and Parallel Reaction Monitoring Increases Sensitivity for Clinical Biomarker Quantitation from FormalinFixed, Paraffin-Embedded Tumor Biopsies | Sweet S, Chain D, Yu W, Martin P, Rebelatto M, Chambers A, Cecchi F, Kim Y | 2022 | bioRxiv | Other | HALO AI | |
Glioblastoma exosomes influence glial cell hyaluronic acid deposition to promote invasiveness< | Koessinger D, Novo D, Koessinger A, Zerbst D, Moore M, Mitchell L, Neilson M, Stevenson K, Chalmers A, Birch J, Norman J | 2022 | bioRxiv | Cytonuclear | HALO | |
The oral drug nitazoxanide restricts SARS-CoV-2 infection and attenuates disease pathogenesis in Syrian hamsters | Miorin L, Mire C, Ranjbar S, Hume A, Huang J, Crossland N, White K, Laporte M, Kehrer T, Haridas V, Moreno E, Nambu A, Jangra S, Cupic A, Dejosez M, Abo K, Tseng A, Werder R, Rathnasinghe R, Mutetwa T, Ramos I, Sainz de Aja J, Garcia de Alba Rivas C, Schotsaert M, Corley R, Falvo J, Fernandez-Sesma A, Kim C, Rossingnol J, Wilson A, Zwaka T, Kotton D, Muhlberger E, Garcia-Sastre A, Goldfeld A | 2022 | bioRxiv | Infectious Disease | Area Quantification | HALO |
Pathogenesis of follicular thymic hyperplasia associated with rheumatoid arthritis | Ohe R, Yang S, Yamashita D, Ichikawa C, Saito A, Kabasawa T, Utsunomiya A, Aung N, Urano Y, Kitaoka T, Suzuki K, Takahara D, Sasaki A, Takakubo Y, Takagi M, Yamakawa M, Futakuchi M | 2022 | Pathology International | Other | Cytonuclear, Multiplex IHC | HALO |
Pancreas resident macrophage-induced fibrosis has divergent roles in pancreas inflammatory injury and PDAC | Baer J, Zuo C, Kang L, Alarcon de la Lastra A, Bocherding N, Knolhoff B, Bogner S, Zhu Y, Lewis M, Zhang N, Kim K, Fields R, Mills J, Ding L, Randolph G, DeNardo D | 2022 | bioRxiv | Fibrosis | Classifier, Area Quantification, Cytonuclear, Multiplex IHC, Highplex FL, Figure Maker | HALO |
Nuclear expression of pSTAT3Tyr705 and pSTAT3Ser727 in the stromal compartment of localized hormone-naïve prostate cancer | Marginean F, Hellsten R, Krzyanowska A, Bjartell A | 2022 | Pathology - Research and Practice | Oncology | Cytonuclear, Multiplex IHC, TMA | HALO |
Extracellular vesicles released after cranial radiation: An insight into an early mechanism of brain injury | Sukati S, Ho J, Chaiswing L, Sompol P, Pandit H, Wei W, Izumi T, Chen Q, Weiss H, Noel T, Bondada S, Butterfield D, St. Cair D | 2022 | Brain Research | Neuroscience | Area Quantification | HALO |
An Fc-inert PD-L1×4-1BB bispecific antibody mediates potent anti-tumor immunity in mice by combining checkpoint inhibition and conditional 4-1BB co-stimulation | Muik A, Altintas I, Gieseke F, Schoedel K, Burm S, Toker A, Salcedo T, Verzijl, Eisel D, Grunwitz C, Kranz L, Vormehr M, Satijn D, Diken M, Kreiter S, Sasser K, Ahmadi T, Tureci O, Breij E, Jure-Kunkel M, Sahin U | 2022 | OncoImmunology | Immuno-oncology | Area Quantification, Immune, Multiplex IHC | HALO |
Eradicating tumor in a recurrent cervical cancer patient with autologous tumorinfiltrating lymphocytes and a modified lymphodepleting regimen | Guo J, Luo N, Ai G, Yang W, Zhu J, Li C, Chen R, Zhang C, Liu S, Jin H, Cheng Z | 2022 | Journal for ImmunoTherapy of Cancer | Immuno-oncology | ||
e The Association of Cholesterol Uptake and Synthesis with Histology and Genotype in Cortisol-Producing Adenoma (CPA) | Motomura N, Yamazaki Y, Koga D, Harashima S, Gao X, Tezuka Y, Omata K, Ono Y, Morimoto R, Satoh F, Nakamura Y, Kwon G, Choi M, Ito A, Sasano H | 2022 | International Journal of Molecular Sciences | Area Quantification, Cytonuclear, Membrane | HALO | |
IgA-dominated humoral immune responses govern patients' outcome in endometrial cancer | Mandal G, Biswas S, Anadon C, Yu X, Gatenbee C, Prabhakaran S, Payne K, Chaurio R, Martin A, Innamarato P, Moran C, Powers J, Harro C, Mine J, Sprenger K, Rigolizzo K, Wang X, Curiel T, Rodriguez P, Anderson A, Saglam O, Conejo-Garcia J | 2021 | Cancer Research | Immuno-oncology | Classifier, Cytonuclear, Highplex FL | HALO |
Tertiary lymphoid structures critical for prognosis in endometrial cancer patients - a TransPORTEC study | Horeweg N, Workel, H, Loiero D, Church D, Vermij L, Léon-Castillo A, Krog R, de Boer S, Nout R, Powel M, Mileshkin L, MacKay H, Leary A, Singh N, Jürgenliemk-Schulz I, Creutzberg C, Koelzer V, Nijman H, Bosse T, Bruyn M | 2022 | Nature Communications | Oncology | Cytonuclear, Multiplex IHC, TMA | HALO, HALO AI |
Genomic and single-cell landscape reveals novel drivers and therapeutic vulnerabilities of transformed cutaneous T-cell lymphoma | Song X, Chang S, Seminario-Vidal L, de Mingo Pulido A, Tordesillas L, Song X, Reed R, Harkins A, Whiddon S, Nguyen J, Segura C, Zhang C, Yoder S, Sayegh Z, Zhao Y, Messina J, Harro C, Zhang X, Conejo-Garcia J, Berglund A, Sokol L, Zhang J, Rodriguez P, Mule J, Futreal A, Tsai K, Chen P | 2022 | Cancer Discovery | Oncology | Cytonuclear, Highplex FL, TMA | HALO |
Collagen-VI expression is negatively mechanosensitive in pancreatic cancer cells and supports the metastatic niche | Papalazarou V, Drew J, Juin A, Spence H, Nixon C, Salmeron-Sanchez M, Machesky L | 2022 | bioRxiv | Oncology | Area Quantification, Figure Maker | HALO |
An immunoPET probe to SARS-CoV-2 reveals early infection of the male genital tract in rhesus macaques | Madden P, Thomas Y, Blair R, Samer S, Doyle M, Midkiff C, Becker M, Arif M, McRaven M, Simons L, Carias A, Martinelli E, Lorenzo-Redondo R, Hultquist J, Villinger F, Veazey R, Hope T | 2022 | bioRxiv | Infectious Disease | HALO | |
Transcriptional and DNA Methylation Signatures of Subcutaneous Adipose Tissue and Adipose-Derived Stem Cells in PCOS Women | Divoux A, Erdos E, Whytock K, Osborne T, Smith S | 2022 | Cells | Area Quantification | HALO | |
Tumor immune cell clustering and its association with survival in African American women with ovarian cancer | Wilson C, Soupir A, Thapa R, Creed J, Nguyen J, Segura C, Gerke T, Schildkraut J, Peres L, Fridley B | 2022 | PLOS Computational Biology | Cytonuclear, Highplex FL | HALO | |
Inhibition of CK2 mitigates Alzheimers tau pathology by preventing NR2B synaptic mislocalization | Marshall C, McBride J, Changolkar L, Riddle D, Trojanowski J, Lee V M-Y | 2022 | Acta Neuropathologica Communications | Area Quantification, | HALO | |
Immunologic Gene Signature Analysis Correlates Myeloid Cells and M2 Macrophages with Time to Trabectedin Failure in Sarcoma Patients | Schroder B, Zhang Y, Smythe K, Desai P, Thomas A, Viveiros P, Alexiev B, Obeidin F, Chen E, Cranmer L, Wagner M, Jones R, Campbell J, Pierce R, He Q, Pollack S | 2022 | Cancers | Oncology | Cytonuclear, Highplex FL | HALO |
Fatal Neurodissemination and SARS-CoV-2 Tropism in K18-hACE2 Mice Is Only Partially Dependent on hACE2 Expression | Carossino M, Kenney D, O'Connell A, Montarnaro P, Tseng A, Gertje H, Grosz K, Ericsson M, Huber B, Kurnick S, Subramaniam S, Kirkland T, Walker J, Francis K, Klose A, Paragas N, Bosmann M, Saeed M, Balasuriya U, Douam F, Crossland N | 2022 | Viruses | Infectious Disease | Classifier, Area Quantification, Highplex FL | HALO |
Multi-modal molecular imaging maps the correlation between tumor microenvironments and nanomedicine distribution | Strittmatter N, Moss J, Race A, Sutton D, Canales J, Ling S, Wong E, Wilson J, Smith A, Howes C, Bunch J, Barry S, Goodwin R, Ashford M | 2022 | Theranostics | Immuno-oncology | Highplex FL | HALO, HALO AI |
An anti-PD-1GITR-L bispecific agonist induces GITR clustering-mediated T cell activation for cancer immunotherapy | Chan S, Belmar N, Ho S, Rogers B, Stickler M, Graham M, Lee E, Tran N, Zhang D, Gupta P, Sho M, MacDonough T, Woolley A, Kim H, Zhang H, Liu W, Zheng P, Dezso Z, Halliwill K, Ceccarelli M, Rhodes S, Thakur A, Forsyth C, Xiong M, Tan S, Iyer R, Lake M, Digiammarino E, Zhou L, Bigelow L, Longenecker K, Judge R, Liu C, Trumble M, Remis J, Fox M, Cairns B, Akamatsu Y, Hollenbaugh D, Farding F, Alvarez H | 2022 | Nature Cancer | Immuno-oncology | Area Quantification, Cytonuclear, Highplex FL | HALO |
ZEB1 transcription factor promotes immune escape in melanoma | Plaschka M, Benboubker V, Grimont M, Berthet J, Tonon L, Lopez J, Le-Bouar M, Balme B, Tondeau G, de la Fouchardiere A, Larue L, Puisieux A, Grinberg-Bleyer Y, Bendriss-Vermare N, Dubois B, Caux C, Dalle S, Caramel J | 2022 | Journal for ImmunoTherapy of Cancer | Immuno-oncology | Cytonuclear, Multiplex IHC, Highplex FL | HALO |
Malfunction of airway basal stem cells plays a crucial role in pathophysiology of tracheobronchopathia osteoplastica | Hong Y, Shan S, Gu Y, Huang H, Zhang Q, Han Y, Dong Y, Liu Z, Huang M, Ren T | 2022 | Nature Communications | Other | Cytonuclear, Multiplex IHC | HALO |
Deep-Learning-Aided Detection of Mycobacteria in Pathology Specimens Increases the Sensitivity in Early Diagnosis of Pulmonary Tuberculosis Compared with Bacteriology Tests | Zaizen Y, Kanhori Y, Ishijima S, Kitamura Y, Yoon H, Ozasa M, Mukae H, Bychkov A, Hoshino T, Fukuoka J | 2022 | Diagnostics | Infectious Disease | HALO, HALO AI | |
Acetyl-CoA-carboxylase 1 (ACC1) plays a critical role in glucagon secretion | Veprik A, Denwood G, Liu D, Bakar R, Morfin V, McHugh K, Tebeka N, Vetterli L, Yonova-Doing E, Gribble F, Reimann F, Hoehn K, Hemsley P, Ahnfelt-Ronne J, Rorsman P, Zhang Q, Wet H, Cantley J | 2022 | Communications Biology | Metabolism | Cytonuclear, Highplex FL | HALO |
Sulforaphane exhibits antiviral activity against pandemic SARS-CoV-2 and seasonal HCoV-OC43 coronaviruses in vitro and in mice | Ordonez A, Bullen C, Villabona-Rueda A, Thompson E, Turner M, Merino V, Yan Y, Kim J, Davis S, Komm O, Powell J, D'Alessio F, Yolken R, Jain S, Jones-Brando L | 2022 | Communications Biology | Infectious Disease | Area Quantification, Multiplex IHC | HALO |
Construction of immune related prognostic model for pancreatic ductal adenocarcinoma based on single cell RNA-seq analysis | Chen K, Wang Q, Liu X, Wang F, Ma Y, Zhang S, Shao Z, Yang Y, Tian X | 2022 | Research Square | Oncology | Cytonuclear, Highplex FL | HALO |
Extracellular matrix proteins regulate NK cell function in peripheral tissues | Bunting M, Vyas M, Requesens M, Langenbucher A, Schiferle E, Manguso R, Lawrence M, Demehri S | 2022 | Science Advances | Dermatology | Cytonuclear, Highplex FL | HALO |
Multiplex Immunohistochemical Phenotyping of T Cells in Primary Prostate Cancer | Ozbek B, Ertunc O, Erickson A, Vidal I, Gomes-Alexandre C, Guner G, Hicks J, Jones T, Taube J, Sfanos K, Yegnasubramanian S, DeMarzo A | 2022 | The Prostate | Immuno-oncology | Classifier, Cytonuclear, Highplex FL, Serial Section, Registration, Figure Maker, TMA | HALO |
Interspatial Distribution of Tumor and Immune Cells in Correlation with PD-L1 in Molecular Subtypes of Gastric Cancers | Dislich B, Mertz K, Gloor B, Langer R | 2022 | Cancers | Immuno-oncology | Multiplex IHC, Spatial Analysis, Figure Maker | HALO |
Adrenal tropism of SARS-CoV-2 and adrenal findings in a post-mortem case series of patients with severe fatal COVID-19 | Paul T, Ledderose S, Bartsch H, Sun N, Soliman S, Markl B, Ruf V, Herms J, Stern M, Keppler O, Delbridge C, Muller S, Piontek G, Kimoto Y, Schreiber F, Williams T, Neumann J, Knosel T, Schulz H, Spallek R, Graw M, Kirchner T, Walch A, Rudelius M | 2022 | Nature Communications | Infectious Disease | Cytonuclear, Highplex FL | HALO |
Soluble TREM2 induces microglia dysfunction and brain damage while cleavage-reduced TREM2 shows sustained microglia activation with enhanced remyelination in the cuprizone model | Beckmann N, Neuhaus A, Zurbruegg S, Joller S, Feuerbach D, Doelemeyer A, Schweizer T, Rudin S, Nuemann U, Berth R, Frieauff W, Gasparani F, Shimshek D | 2022 | Research Square | Neuroscience | HALO | |
Genome-wide mapping of oncogenic pathways and genetic modifiers of chemotherapy using a high-risk hepatoblastoma genetic model | Fang J, Singh S, Natarajan S, Tillman H, Abuzaid A, Durbin A, Lee H, Wu Q, Steele J, Connelly J, Cheng C, Jin H, Chen W, Fan Y, Pruett-Miller S, Rehg J, Emmons J, Cairo S, Wang R, Glazer E, Murphy A, Chen T, Davidoff A, Easton J, Chen X, Yang J | 2022 | Research Square | Oncology | Classifier | HALO |
Spatially mapping the immune landscape of melanoma using imaging mass cytometry | Moldoveanu D, Ramsay L, Lajoie M, Anderson-Trocme L, Lingrand M, Berry D, Perus L, Wei Y, Moraes C, Alkallas R, Rajkumar S, Zuo D, Dankner M, Xu E, Bertos N, Najafabadi H, Gravel S, Costantino S, Richer M, Lund A, Del Rincon S, Spatz A, Miller W, Jamal R, Lapointe R, Mes-Masson A, Turcotte S, Petrecca K, Dumitra S, Meguerditchian A, Richardson K, Tremblay F, Wang B, Chergui M, Guiot M, Watters K, Stagg J, Quail D, Mihalcioiu C, Meterissian S, Watson I | 2022 | Science Immunology | Oncology | Highplex FL | HALO |
Improved cognitive impairments by silencing DMP1 via enhancing the proliferation of neural progenitor cell in Alzheimer-like mice | Zhao H, Wei J, Du Y, Chen P, Liu X, Liu H | 2022 | Aging Cell | Neuroscience | Cytonuclear, Highplex FL | HALO |
A tumor suppressor role for EZH2 in diffuse midline glioma pathogenesis | Dhar S, Gadd S, Patel P, Vaynshteyn Jm Raju G, Hashizume R, Brat D, Becher O | 2022 | Acta Neuropathologica Communications | Neuroscience | HALO | |
Loss of ubiquitin-specific peptidase 18 destabilizes 14-3-3? protein and represses lung cancer metastasis | Chen Z, Zheng L, Chen Y, Liu X, Kawakami M, Mustachi L, Roszik J, Ferry-Galow K, Parchment R, Liu X, Andresson T, Duncan G, Kurie J, Rodriguez-Canales J, Liu X, Dmitrovsky E | 2022 | Cancer Biology & Therapy | Oncology | Classifier, Cytonuclear | HALO |
Ad26.COV2.S prevents upregulation of SARS-CoV-2 induced pathways of inflammation and thrombosis in hamsters and rhesus macaques | Aid M, Vidal S, Piedra-Mora C, Ducat S, Chan C, Bondoc S, Colarusso A, Starke C, Nekorchuk M, Busman-Sahay K, Estes J, Martinot A, Barouch D | 2022 | PLOS Pathogens | Infectious Disease | Area Quantification, Multiplex IHC | HALO, HALO AI |
Clinical tissue biomarker digital image analysis: A review of current applications | Li Z, Bui M, Pantanowitz L | 2022 | Human Pathology Reports | Review | HALO | |
Peritumoral TIGIT+CD20+ B cell infiltration indicates poor prognosis but favorable adjuvant chemotherapeutic response in gastric cancer | Liu H, Wu J, Xu X, Wang H, Zhang C, Yin S, He Y | 2022 | International Immunopharmacology | Oncology | Cytonuclear, Spatial Analysis, Highplex FL | HALO |
Subpopulations of cancer-associated fibroblasts link the prognosis and metabolic features of pancreatic ductal adenocarcinoma | Hu B, Wu C, Mao H, Gu H, Dong H, Yan J, Qi Z, Yuan L, Dong Q, Long J | 2022 | Annals of Translational Medicine | Oncology | Cytonuclear, Highplex FL | HALO |
Vertical transmission of attaching and invasive E. coli from the dam to neonatal mice predisposes to more severe colitis following exposure to a colitic insult later in life | Brand M, Proctor A, Hostetter J, Zhou N, Friedberg I, Jergens A, Phillips G, Wannemuehler M | 2022 | PLOS ONE | Other | ISH/FISH | HALO |
Advanced Age and Neurotrauma Diminish Glutathione and Impair Antioxidant Defense after Spinal Cord Injury | Stewart A, Glaser E, Mott C, Bailey W, Sullivan P, Patel S, Gensel J | 2022 | Journal of Neurotrauma | Neuroscience | Axon | HALO |
Humanized mice reveal a macrophage-enriched gene signature defining human lung tissue protection during SARS-CoV-2 infection | Kenney D, O'Connell A, Turcinovic J, Montanaro P, Hekman R, Tamura T, Berneshawi A, Cafiero T, Abdullatif S, Blum B, Goldstein S, Heller B, Gertje H, Bullitt E, Trachtenberg A, Chavez E, Nono E, Morrison C, Tseng A, Sheikh A, Kurnick S, Grosz K, Bosmann M, Ericsson M, Huber B, Saeed M, Balazs A, Francis K, Klose A, Paragas N, Campbell J, Connor J, Emili A, Crossland N, Ploss A, Douam F | 2022 | Cell Reports | Infectious Disease | Area Quantification, Highplex FL | HALO |
A Deep Learning Convolutional Neural Network Can Differentiate Between Helicobacter Pylori Gastritis and Autoimmune Gastritis With Results Comparable to Gastrointestinal Pathologists | Franklin M, Schultz F, Tafoya M, Kerwin A, Broehm C, Fischer E, Gullapalli R, Clark D, Hanson J, Martin D | 2022 | Archives of Pathology & Laboratory Medicine | Oncology, Gastroenterology | HALO, HALO AI | |
Interface astrogliosis in contact sport head impacts and military blast exposure | Babcock K, Abdolmohammadi B, Kiernan P, Mahar I, Cherry J, Alvarez V, Goldstein L, Stein T, McKee, Huber B | 2022 | Acta Neuropathologica Communications | Neruoscience | Area Quantification | HALO |
The GBA1 D409V mutation exacerbates synuclein pathology to differing extents in two alpha-synuclein models | Polinski N, Martinez T, Ramboz S, Sasner M, Herberth M, Switzer R, Ahmad S, Pelligrino L, Clark S, Marcus J, Smith S, Dave K, Frasier M | 2022 | Disease Models & Mechanisms | Neuroscience | Object Colocalization | HALO |
Organelle resolved proteomics reveals new chordoma cell surface markers required for proliferation and association with outcome | Khan S, Zuccato J, Ignatchenko V, Singh O, Govindarajan M, Waas M, Gao A, Zadeh G, Kislinger T | 2022 | Research Square | Oncology | Cytonuclear, Multiplex IHC | HALO |
Intraoperative abobotulinumtoxinA alleviates pain after surgery and improves general wellness in a translational animal model | Cornet S, Carre D, Limana L, Castel D, Meilin S, Horn R, Pons L, Evans S, Lezmi S, Kalinichev M | 2022 | Research Square | Other | Area Quantification, Object Colocalization | HALO |
Immune cell subsets in interface cutaneous immune-related adverse events (cirAEs) associated with anti-PD-1 therapy resemble accute graft vs host disease more than licen planus | Cruz G, Kaunitz G, Stein J, Sander I, Hollmann T, Cottrell T, Taube J, Sunshine J | 2022 | Journal of Cutaneous Pathology | Immunology | Cytonuclear, Multiplex IHC | HALO |
Therapeutic impact of BET inhibitor BI 894999 treatment: backtranslation from the clinic | Tontsch-Grunt U, Traexler P, Baum A, Musa H, Marzin K, Wang S, Trapani F, Engelhardt H, Solca F | 2022 | British Journal of Cancer | Oncology | Classifier, Cytonuclear, Multiplex IHC | HALO |
Immune and epithelial determinants of age-related risk and alveolar injury in fatal COVID-19 | Chait M, Yilmaz M, Shakil S, Ku A, Dogra P, Connors T, Szabo P, Gray J, Wells S, Kubota M, Matsumoto R, Poon M, Snyder M, Baldwin M, Sims P, Saqi A, Farber D, Weisberg S | 2022 | JCI Insight | Infectious Disease | Multiplex IHC | HALO |
Neuropathology and virus in brain of SARS-CoV-2 infected non-human primates | Rutkai I, Mayer M, Hellmers L, Ning B, Huang Z, Monjure C, Coyne C, Silvestri R, Golden N, Hensley K, Chandler K, Lehmicke G, Bix G, Maness N, Russell-Lodrigue K, Hu T, Roy C, Blair R, Bohm R, Doyle-Meyers L, Rappaport J, Fisher T | 2022 | Nature Communications | Infectious Disease | Area Quantification | HALO |
Increased apoptotic sensitivity of glioblastoma enables therapeutic targeting by BH3-mimetics | Koessinger A, Cloix C, Koessinger D, Heiland D, Bock F, Strathdee K, Kinch K, Martinez-Escardo L, Paul N, Nixon C, Malviya G, Jackson M, Campbell K, Stevenson K, Davis S, Elmasry Y, Ahmed A, O'Prey J, Ichim G, Schnell O, Stewart W, Blyth K, Ryan K, Chalmers A, Norman J, Tait S | 2022 | Cell Death & Differentiation | Oncology | HALO | |
SPOP promotes cervical cancer progress by inducing PD-1 move away from PD-L1 in spatial localization | Wu J, Wu Y, Guo Q, Chen S, Wang S, Zhu J, Wu X, Ju X | 2022 | Research Square | Oncology | Cytonuclear, Spatial Analysis, Highplex FL, TMA | HALO |
Hyperpolarized 13C-Pyruvate Metabolism as a Surrogate for Tumor Grade and Poor Outcome in Renal Cell CarcinomaA Proof of Principle Study | Ursprung S, Woitek R, McLean M, Priest A, Crispin-Ortuzar M, Brodie C, Gill A, Gehrung M, Beer L, Riddick A, Field-Rayner J, Grist J, Deen S, Riemer F, Kaggie J, Zaccagna F, Duarte J, Locke M, Frary A, Aho T, Armitage J, Casey R, Mendichovszky I, Welsh S, Barrett T, Graves M, Eisen T, Mitchell T, Warren A, Brindle K, Sala E, Stewart G, Gallagher F | 2022 | Cancers | Oncology | Area Quantification, Cytonuclear, Multiplex IHC | HALO |
Title (click the + for more info) | Authors | Year | Journal | Application | HALO Modules | Product |
---|---|---|---|---|---|---|
Stem cellderived CAR T cells traffic to HIV reservoirs in macaques | Barber-Axthelm IM, Barber-Axthelm V, Sze KY, Zhen A, Suryawanshi GW, Chen ISY, Zack JA, Kitchen SG, Kiem H-P, Peterson CW | 2021 | JCI Insight | Immunology, Infectious Disease | Area Quantification | HALO |
IL-1-driven stromal-neutrophil interaction in deep ulcers defines a pathotype of therapy non-responsive inflammatory bowel disease | Friedrich M, Pohin M, Jackson MA, Korsunsky I, Bullers S, Rue-Albrecht K, Christoforidou Z, Sathananthan D, Ravindran R, Peres RS, Sharpe H, Wei K, Watts GFM, Mann EH, Geremia A, Thomas T, Attar M, Oxford IBD Cohort Investigators, Roche Fibroblast Network Consortium, McCuaig S, Thomas L, Collantes E, Uhlig HH, Sansom S, Easton A, Raychaudhuri S, Travis SP, Powrie FM | 2021 | bioRxiv | Immunology | Cytonuclear | HALO |
Highly Fermentable Fiber Alters Fecal Microbiota and Mitigates Swine Dysentery Induced by Brachyspira hyodysenteriae | Helm ET, Gabler NK, Burrough ER | 2021 | Animals | Infectious Disease | Cytonuclear | HALO |
Vascular endothelial ERp72 is involved in the inflammatory response in a rat model of skeletal muscle injury | Khalaf NB, Al-Mehatab D, Fathallah DM | 2021 | Medicine Reports | Immunology | Cytonuclear | HALO |
Lipid Source and Peroxidation Status Alter Immune Cell Recruitment in Broiler Chicken Ileum | Fries-Craft KA, Meyer MM, Lindblom SC, Kerr BJ, Bobeck EA | 2021 | The Journal of Nutrition | Immunology | ISH/FISH | HALO |
Frontotemporal lobar degeneration proteinopathies have disparate microscopic patterns of white and grey matter pathology | Giannini LAA, Peterson C, Ohm D, Xie SX, McMillan CT, Raskovsky K, Massimo L, Suh E, Van Deerlin VM, Wolk DA, Trojanowski JQ, Lee EB, Grossman M, Irwin DJ | 2021 | Acta Neuropathologica Communications | Neuroscience | Area Quantification | HALO |
Fasting reverses drug-resistance in hepatocellular carcinoma through p53-dependent metabolic synergism | Krstic J, Reinisch I, Schindlmaier K, Galhuber M, Berger N, Kupper N, Moyschewitz E, Auer M, Michenthaler H, Nössing C, Depaoli MR, Ramadani-Muja J, Stryeck S, Pichler M, Rinner B, Deutsch AJA, Reinisch A, Madl T, Chiozzi RZ, Heck AJR, Huch M, Malli R, Prokesch A | 2021 | bioRxiv | Oncology | Classifier, Cytonuclear | HALO |
Recruitment of KRAS downstream target ARL4C to membrane protrusions accelerates pancreatic cancer cell invasion | Harada A, Matsumoto S, Yasumizu Y, Akama T, Eguchi H, Kikuchi A | 2021 | bioRxiv | Oncology | Area Quantification | HALO |
Potential role of M2 TAMs around lymphatic vessels during lymphatic invasion in papillary thyroid carcinoma | Kabasawa T, Ohe R, Aung NY, Urano Y, Kitaoka T, Tamazawa N, Utsunomiya A, Yamakawa M | 2021 | Scientific Reports | Oncology | Area Quantification | HALO |
Amylin deposition activates HIF1? and 6-phosphofructo-2-kinase/fructose-2, 6-biphosphatase 3 (PFKFB3) signaling in failing hearts of non-human primates | Liu M, Li N, Qu C, Gao Y, Wu L, Hu LG | 2021 | Communications Biology | Metabolism | Area Quantification, Cytonuclear | HALO |
BMP pathway antagonism by Grem1 regulates epithelial cell fate in intestinal regeneration | Koppens MAJ, Davis H, Valbuena GN, Mulholland EJ, Nasreddin N, Colombe M, Antanaviciute A, Biswas S, Friedrich M, Lee L, Oxford IBD cohort investigators, Wang LM, Koelzer VH, East JE, Simmons A, Winton DJ, Leedham SJ | 2021 | bioRxiv | Gastroenterology | Area Quantification | HALO |
A distinct repertoire of cancer-associated fibroblasts is enriched in cribriform prostate cancer | Hesterberg AB, Rios BL, Wolf EM, Tubbs C, Wong HY, Schaffer KR, Lotan TL, Giannico GA, Gordetsky JB, Hurley PJ | 2021 | Journal of Pathology:Clinical Research | Oncology | Classifier, ISH/FISH | HALO |
Dystrophic microglia are associated with neurodegenerative disease and not healthy aging in the human brain | Shahidehpour RK, Higdon RE, Crawford NG, Neltner JH, Ighodaro ET, Patel E, Price D, Nelson PT, Bachstetter AD | 2021 | Neurobiology of Aging | Neuroscience | Area Quantification | HALO |
Inhibition of Hedgehog signaling alters fibroblast composition in pancreatic cancer | Steele NG, Biffi G, Kemp SB, Zhang Y, Drouillard D, Syu L-J, Hao Y, Oni TE, Brosnan E, Elyada E, Doshi A, Hansma C, Espinoza C, Abbas A, The S, Irizarry-Negron VM, Halbrook CJ, Franks N, Hoffman M, Brown KL, Carpenter ES, Nwosu ZC, Johnson C, Lima F, Anderson MA, Park Y, Crawford HC, Lyssiotis CA, Frankel TF, Rao A, Bednar F, Dlugosz AA, Preall J, Tuveson DA, Allen B, di Magliano MP | 2021 | Clinical Cancer Research | Oncology | Area Quantification | HALO |
Locally confined IFN? production by CD4+ T cells provides niches for murine cytomegalovirus 4 replication in the salivary gland | Oderbolz J, Zangger N, Zimmerman L, Sandu I, Starruß J, Graw F, Oxenius A | 2021 | bioRxiv | Classifier, Spatial Analysis, Highplex FL | HALO | |
Kaiso (ZBTB33) subcellular partitioning functionally links LC3A/B, the tumor microenvironment, and breast cancer survival | Singhal SK, Byun JS, Park S, Yan T, Yancey R, Caban A, Hernandez SG, Hewitt SM, Boisvert H, Hennek S, Bobrow M, Ahmed SU, White J, Yates C, Aukerman A, Vanguri R, Bareja R, Lenci R, Farré PL, De Siervi A, Nápoles AM, Vohra N, Gardner K | 2021 | Communications Biology | Oncology | Cytonuclear, TMA | HALO |
Deep Learning-Based Annotation Transfer between Molecular Imaging Modalities: An Automated Workflow for Multimodal Data Integration | Race AM, Sutton D, Hamm G, Maglennon G, Morton JP, Strittmatter N, Campbell A, Sansom OJ, Wang Y, Barry ST, Takáts Z, Goodwin RJA, Bunch J | 2021 | Analytical Chemistry | Oncology | HALO AI | |
Integrative molecular characterization of sarcomatoid and rhabdoid renal cell carcinoma | Bakouny Z, Braun DA, Shukla SA, Pan W, Gao X, Hou Y, Flaifel A, Tang S, Bosma-Moody A, He MX, Vokes N, Nyman J, Xie W, Nassar AH, Alaiwi SA, Flippot R, Bouchard G, Steinharter JA, Nuzzo PV, Ficial M, SantAngelo M, Forman J, Berchuck JE, Dudani S, Bi K, Park J, Camp S, Sticco-Ivins M, Hirsch L, Baca SC, Wind-Rotolo M, Ross-Macdonald P, Sun M, Mary Lee G-SM, Chang SL, Wei XX, McGregor BA, Harshman LC, Genovese G, Ellis L, Pomerantz M, Hirsch MS, Freedman ML, Atkins MB, Wu CJ, Ho TH, Linehan WM, McDermott DF, Heng DYC, Viswanathan SR, Signoretti S, Van Allen EM, Choueiri TK | 2021 | Nature Communications | Oncology | Highplex FL | HALO |
IgA transcytosis and antigen recognition govern ovarian cancer immunity | Biswas S, Mandal G, Payne KK, Anadon CM, Gatenbee CD, Chaurio RA, Costich TL, Moran C, Harro CM, Rigolizzo KE, Mine JA, Trillo-Tinoco J, Sasamoto N, Terry KL, Marchion D, Buras A, Wenham RM, Yu X, Townsend MK, Tworoger SS, Rodriguez CR, Anderson AR, Conejo-Garcia JR | 2021 | Nature | Immuno-oncology | Highplex FL | HALO |
Characterization of Macrophages and Osteoclasts in the Osteosarcoma Tumor Microenvironment at Diagnosis: New Perspective for Osteosarcoma Treatment? | Gomez-Brouchet A, Gilhodes J, Van Acker N, Brion R, Bouvier C, Assemat P, Gaspar N, Aubert S, Guinebretiere J-M, Marie B, Larousserie F, Entz-Werlé N, de Pinieux G, Mascard E, Gouin F, Brousset P, Tabone M-D, Jimenez M, Le Deley M-C, Blay J-Y, Brugieres L , Piperno-Neumann S, Rédini F | 2021 | Cancers | Immuno-oncology | Highplex FL | HALO |
CD30+OX40+ Treg is associated with improved overall survival in colorectal cancer | Lam JH, Hong M, Koo S-L, Chua CWL, Lim KL, Wee F, Wan WK, Leow WQ, Yeo JG, Tan IBH, Yeong J, Lim TKH, Lim TS | 2021 | Cancer Immunology, Immunotherapy | Immuno-oncology | Highplex FL | HALO |
Sustained Helicobacter pylori infection accelerates gastric dysplasia in a mouse model | OBrien VP, Koehne AL, Dubrulle J, Rodriguez AE, Leverich CK, Kong VP, Campbell JS, Pierce RH, Goldenring JR, Choi E, Salama NR | 2021 | Life Science Alliance | Immuno-oncology | Highplex FL | HALO |
A feasibility study of combined epigenetic and vaccine therapy in advanced colorectal cancer with pharmacodynamic endpoint | Bever KM, Thomas DL, Zhang J, Rivera EAD, Rosner GL, Zhu Q, Nauroth JM, Christmas B, Thompson ED, Anders RA, Judkins C, Liu M, Jaffee EM, Ahuja N, Zheng L, Azad NS | 2021 | Clinical Epigenetics | Oncology | Immune, Membrane | HALO |
CD8+ T cells fail to limit SIV reactivation following ART withdrawal until after viral amplification | Okoye AA, Duell DD, Fukazawa Y, Varco-Merth B, Marenco A, Behrens H, Chaunzwa TM, Selseth AN, Gilbride RM, Shao J, Edlefsen PT, Geleziunas R, Pinkevych M, Davenport MP, Busman-Sahay K, Nekorchuk MD, Park H, Smedley JV, Axthelm MK, Estes JD, Hansen SG, Keele BF, Lifson JD, Picker LJ | 2021 | The Journal of Clinical Investigation | Immunology, Infectious Disease | ISH/FISH | HALO |
The effect of cyfluthrin on testis inhibin B in rats and the intervention of Lycium barbarum polysaccharide | Guo X, Xie Y-X, Guo C, Wei J-L, Yang H-F | 2021 | Molecular & Cellular Toxicology | Toxicology | Multiplex IHC | HALO |
Cooperative targeting of immunotherapy-resistant melanoma and lung cancer by an AXL-targeting antibody-drug conjugate and immune checkpoint blockade | Boshuizen J, Pencheva N, Krijgsman O, Altimari DD, Castro PG, de Bruijn B, Ligtenberg MA, den Heuvel EG, Vredevoogd DW, Song J-Y, Visser N, Apriamashvili G, Janmaat ML, Plantinga TS, Franken P, Houtkamp M, Lingnau A, Jure-Kunkel M, Peeper DS | 2021 | Cancer Research | Immuno-oncology | HALO | |
ATP-binding cassette transporters restrict drug delivery and efficacy against brain tumors even when blood-brain barrier integrity is lost | de Gooijer MC, Kemper EM, Buil LCM, Citirikkaya CH, Buckle T, Beijnen JH, van Tellingen O | 2021 | Cell Reports Medicine | Oncology | HALO | |
The amino acid transporter SLC7A5 is required for efficient growth of KRAS-mutant colorectal cancer | Najumudeen AK, Ceteci F, Fey SK, Hamm G, Steven RT, Hall H, Nikula CJ, Dexter A, Murta T, Race AM, Sumpton D, Vlahov N, Gay DM, Knight JRP, Jackstadt R, Leach JDG, Ridgway RA, Johnson ER, Nixon C, Hedley A, Gilroy K, Clark W, Malla SB, Dunne PD, Rodriguez-Blanco G, Critchlow SE, Mrowinska A, Malviya G, Solovyev D, Brown G, Lewis DY, Mackay GM, Strathdee D, Tardito S, Gottlieb E, CRUK Rosetta Grand Challenge Consortium, Takats Z, Barry ST, Goodwin RJA, Bunch J, Bushell M, Campbell AD, Sansom OJ | 2021 | Nature Genetics | Oncology | HALO | |
Single-cell analysis shows that adipose tissue of persons with both HIV and diabetes is enriched for clonal, cytotoxic, and CMV-specific CD4+ T cells | Wanjalla CN, McDonnell WY, Ram R, Chopra A, Gangula R, Leary S, Mashayekhi M, Simmons JD, Warren CM, Bailin S, Gabriel CL, Cuo L, Furch BD, Lima MC, Woodward BO, Hannah L, Pilkinton MA, Fuller DT, Kawai K, Virmani R, Finn AV, Hasty AH, Mallal SA, Kalams SA, Koethe JR | 2021 | Cell Reports Medicine | Immunology, Metabolism | HALO | |
Acute Respiratory Distress in Aged, SARS-CoV-2 Infected African Green Monkeys but not Rhesus Macaques | Blair RV, Vaccari M, Doyle-Meyers LA, Roy CJ, Russell-Lodrigue K, Fahlberg M, Monjure CJ, Beddingfield B, Plante KS, Plante JA, Weaver SC, Qin X, Midkiff CC, Lehmicke G, Golden N, Threeton B, Penney T, Allers C, Barnes MB, Pattison M, Datta PK, Maness NJ, Birnbaum A, Fischer T, Bohm RP, Rappaport J | 2020 | The American Journal of Pathology | Infectious Disease | Classifier | HALO |
Association of COVID-19 inflammation with activation of the C5aC5aR1 axis | Carvelli J, Demaria O, Vely F, Batista L, Benmansour NC, Fares J, Carpentier S, Thibult M-L, Morel A, Andre P, Represa A, Piperoglou C, Cordier PY, Le Dault E, Guervilly C, Simone P, Gainnier M, Morel Y, Ebbo M, Schleinitz N, Vivier E | 2020 | Nature | Immunology | Cytonuclear | HALO |
Impact of Preanalytical Factors During Histology Processing on Section Suitability for Digital Image Analysis | Chlipala EA, Butters M, Brous M, Fortin JS, Archuletta R, Copeland K, Bolon B | 2020 | Toxicologic Pathology | Toxicology | Area Quantification, Cytonuclear | HALO |
Tumor vessel normalization, immuno-stimulatory reprogramming, and improved survival in glioblastoma with combined inhibition of PD-1, angiopoietin-2, and VEGF | Di Tacchio M, Macas J, Weissenberger J, Sommer K, Bähr O, Steinbach JP, Senft C, Seifert V, Glas M, Herrlinger U, Krex D, Meinhardt M, Weyerbrock A, Timmer M, Goldbrunner R, Deckert M, Scheel AH, Büttner R, Grauer OM, Schittenhelm J, Tabatabai G, Harter PN, Guenther S, Devraj K, Plate KH, Reiss Y | 2020 | Cancer Immunology Research | Oncology, Immuno-oncology | Classifier, Cytonuclear | HALO |
Immune cell landscaping reveals a protective role for regulatory T cells during kidney injury and fibrosis | do Valle Duraes F, Lafont A, Biebel M, Martin K, Darribat K, Cuttat R, Waldt A, Naumann U, Wieczorek G, Gaulis S, Pfister S, Mertz KD, Li J, Roma G, Warncke M | 2020 | JCI Insight | Immunology | Area Quantification, Cytonuclear | HALO |
The prevalence and prognostic significance of estrogen receptor beta expression in non-small cell lung cancer | Enwere EK, Dean ML, Li H, D'Silva A, Bebb DG | 2020 | Translational Lung Cancer Research | Oncology | Cytonuclear, TMA | HALO |
Dendritic Cell Paucity Leads to Dysfunctional Immune Surveillance in Pancreatic Cancer | Hedge S, Krisnawan VE, Herzog BH, Zuo C, Breden MA, Knolhoff BL, Hogg GD, Tang JP, Baer JM, Mpoy C, Lee KB, Alexander KA, Rogers BE, Murphy KM, Hawkins WG, Fields RC, DeSelm CJ, Schwarz JK, DeNardo DG | 2020 | Cancer Cell | Oncology, Immuno-oncology | Area Quantification, Cytonuclear, Immune | HALO |
Periconceptional exposure to lopinavir, but not darunavir, impairs decidualization: a potential mechanism leading to poor birth outcomes in HIV-positive pregnancies | Kala S, Dunk C, Acosta S, Serghides L | 2020 | Human Reproduction | Infectious Disease | Cytonuclear | HALO |
Three-dimensional culture models mimic colon cancer heterogeneity induced by different microenvironments | Kawai S, Yamazaki M, Shibuya K, Yamazaki M, Fujji E, Nakano K, Suzuki M | 2020 | Scientific Reports | Oncology | Cytonuclear | HALO |
Epithelial-mesenchymal transition of absorptive enterocytes and depletion of Peyer's patch M cells after PEDV infection | Chen Y-M, Helm ET, Groeltz-Thrush, Gabler NK, Burrough ER | 2020 | Virology | Immunology | Area Quantification | HALO |
Imaging breast cancer using hyperpolarized carbon-13 MRI | Gallagher FA, Woitek R, McLean MA, Gill AB, Garcia RM, Provenzano E, Riemer F, Kaggie J, Chhabra A, Ursprung S, Grist JT, Daniels CJ, Zaccagna F, Laurent M-C, Locke M, Hilborne S, Frary A, Torheim T, Boursnell C, Schiller A, Patterson I, Slough R, Carmo B, Kane J, Biggs H, Harrison E, Deen SS, Patterson A, Lanz T, Kingsbury Z, Ross M, Basu B, Baird R, Lomas DJ, Sala E, Wason J, Rueda OM, Chin S-F, Wilkinson IB, Graves MJ, Abraham JE, Gilbert FJ, Caldas C, Brindle KM | 2020 | Proceedings of the National Academy of Sciences | Oncology | Area Quantification | HALO |
Conformation-selective tau monoclonal antibodies inhibit tau pathology in primary neurons and a mouse model of Alzheimers disease | Gibbons GS, Kim S-J, Wu Q, Riddle DM, Leight SN, Changolkar L, Xu H, Meymand ES, O'Reilly M, Zhang B, Brunden KR, Trojanowski JQ, Lee VMY | 2020 | Molecular Neurodegeneration | Neuroscience | Area Quantification | HALO |
TGF?-blockade uncovers stromal plasticity in tumors by revealing the existence of a subset of interferon-licensed fibroblasts | Grauel AL, Nguyen B, Ruddy D, Laszewski T, Schwartz S, Chang J, Chen J, Piquet M, Pelletier M, Yan Z, Kirkpatrick ND, Wu J, deWeck A, Riester M, Hims M, Geyer FC, Wagner J, MacIsaac K, Deeds J, Diwanji R, Jayaraman P, Yu Y, Simmons Q, Weng S, Raza A, Minie B, Dostalek M, Chikkegowda P, Ruda V, Iartchouk O, Chen N, Thierry R, Zhou J, Pruteanu-Malinici I, Fabre C, Engelman JA, Dranoff G, Cremasco V | 2020 | Nature Communications | Oncology | Area Quantification | HALO |
Ex-vivo delivery of monoclonal antibody (Rituximab) to treat human donor lungs prior to transplantation | Ku TJY, Ribeiero RVP, Ferreira VH, Galasso M, Keshavjee S, Kumar D, Cypel M, Humar A | 2020 | EBioMedicine | Other | Classifier, Cytonuclear | HALO |
Transmission of tauopathy strains is independent of their isoform composition | He Z, McBride JD, Zu, Changolkar L, Kim S, Zhang B, Narasimhan S, Gibbons GS, Kozak M, Schellenberg GD, Trrojanowski JQ, Lee VM-Y | 2020 | Nature Communications | Neuroscience | Area Quantification | HALO |
Human cardiac fibroblasts expressing VCAM1 improve heart function in postinfarct heart failure rat models by stimulating lymphangiogenesis | Iwamiya T, Segnard B-D, Matsuoka Y, Imamura T | 2020 | PLOS One | Myology | Area Quantification | HALO |
Environmental contaminant ammonia triggers epithelial-to-mesenchymal transition-mediated jejunal fibrosis with the disassembly of epithelial cell-cell contacts in chicken | Jing H, Wang S, Wang Y, Shen N, Gao X-J | 2020 | ScienceTotalEnvrt | Toxicology | Area Quantification | HALO |
Cholinergic receptors on intestine cells of Ascaris suum and activation of nAChRs by levamisole | McHugh M, Williams P, Verma S, Powell-Coffman JA, Robertson AP, Martin RJ | 2020 | International Journal for Parasitology: Drugs and Drug Resistance | Gastroenterology, Infectious Disease | Area Quantification | HALO |
Adult onset pan-neuronal human tau tubulin kinase 1 expression causes severe cerebellar neurodegeneration in mice | McMillan P, Wheeler J, Gatlin RE, Taylor L, Strovas T, Baum M, Bird TD, Latimer C, Keene CD, Kraemer BC, Liachko NF | 2020 | Acta Neuropathologica Communications | Neuroscience | Area Quantification | HALO |
Spatial immune profiling of the colorectal tumor microenvironment predicts good outcome in stage II patients | Nearchou IP, Gwyther BM, Georgiakakis ECT, Gavriel CG, Kajiwara Y, Ueno H, Harrison DJ, Caie PD | 2020 | Digital Medicine | Immuno-oncology | Classifier, Area Quantification, Spatial Analysis | HALO |
11? hydroxysteroid dehydrogenase 1: a new marker for predicting response to immune-checkpoint blockade therapy in non-small-cell lung carcinoma | Saito R, Miki Y, Abe T, Miyauchi E, Abe J, Nanamiya R, Inoue C, Sato I, Sasano H | 2020 | British Journal of Cancer | Immuno-oncology | Area Quantification | HALO |
Clinicopathological significance of endoplasmic reticulum stress proteins in ovarian carcinoma | Samanta S, Tamura S, Dubeau L, Mhawech-Fauceglia P, Miyagi Y, Kato H, Lieberman R, Buckanovich RJ, Lin YG, Neamati N | 2020 | Scientific Reports | Oncology | Area Quantification | HALO |
Prognostic value of tumor-inltrating immune cells in primary colorectal cancer and metastases | Martin SZ, Tagscherer KE, Deckert S, Horst D, Moehler M, Lang H, Roth W | 2020 | *Pre-Print | Immuno-oncology | Classifier, Cytonuclear | HALO |
Implementation of PD-L1 22C3 IHC pharmDxTM in Cell Block Preparations of Lung Cancer: Concordance with Surgical Resections and Technical Validation of CytoLyt® Prefixation | Lou SK, Ko HM, Kinoshita T, MacDonald S, Weiss J, Czarnecka-Kujawa K, Boerner SL, Yasufuku K, Tsao M-S, Schwock J | 2020 | Acta Cytologica | Oncology | Classifier, Membrane | HALO |
Immuno-Interface Score to Predict Outcome in Colorectal Cancer Independent of Microsatellite Instability Status | Nestarenkaite A, Fadhil W, Ramusson A, Susanti S, Hadjimichael E, Laurinaviciene A, Ilyas M, Laurinavicius A | 2020 | Cancers | Immuno-oncology | Classifier, Multiplex IHC | HALO |
Assessment of associations between clinical and immune microenvironmental factors and tumor mutation burden in resected nonsmall cell lung cancer by applying machine learning to whole-slide images | Ono A, Terada Y, Kawata T, Serizawa M, Isaka M, Kawabata T, Imai T, Mori K, Muramatsu K, Hayashi I, Kenmotsu H, Oshima K, Urakami K, Nagashima T, Kusuhara M, Akiyama Y, Sugino T, Ohde Y, Yamaguchi K, Takahashi T T | 2020 | Cancer Medicine | Classifier, Multiplex IHC, Serial Section | HALO | |
Prevalence of CD8+ cytotoxic lymphocytes in human neoplasms | Blessin NC, Spriestersbach P, Li W, Mandelkow T, Dum D, Simon R, Hube-Magg C, Lutz F, Viehweger F, Lennartz M, Fraune C, Nickelsen V, Fehrle W, Göbel C, Weidemann S, Clauditz T, Lebok P, Möller K, Steurer S, Izbicki JR, Sauter G, Minner S, Jacobsen F, Luebke AM, Büscheck F, Höflmayer D, Wilczak W, Burandt E, Hinsch A | 2020 | Cellular Oncology | Oncology, Immuno-oncology | Membrane, TMA | HALO |
Persistence of adoptively transferred T cells with a kinetically engineered IL-2 receptor agonist | Parisi G, Saco JD, Salazar FB, Tsoi J, Krystofinski P, Puig-Saus C, Zhang R, Zhou J, Cheung-Lau GC, Garcia AJ, Grasso CS, Tavaré R, Hu-Lieskovan S, Mackay S, Zalevsky J, Bernatchez C, Diab A, Wu AM , Comin-Anduix B, Charych D, Ribas A | 2020 | Nature Communications | Oncology, Immuno-oncology | Cytonuclear | HALO |
Mechanical regulation of glycolysis via cytoskeleton architecture | Park JS, Burckhardt CJ, Lazcano R, Solis LM, Isogai T, Li L, Chen CS, Gao B, Minna JD, Bachoo R, DeBerardinis RJ, Danuser G | 2020 | Nature | Oncology | Classifier, Cytonuclear, TMA | HALO |
Naproxen chemoprevention promotes immune activation in Lynch syndrome colorectal mucosa | Reyes-Uribe L, Wu W, Gelincik O, Bommi PV, Francisco-Cruz A, Solis LM, Lynch PM, Lim R, Stoffel EM, Kanth P, Samadder NJ, Mork ME, Taggart MW, Milne GL, Marnett LJ, Vornik L, Liu DD, Revuelta M, Chang K, You YN, Kopelovich L, Wistuba II, Lee JJ, Sei S, Shoemaker RH, Szabo E, Richmond E, Umar A, Perloff M, Brown PH, Lipkin SM, Vilar E | 2020 | Gut | Oncology | Classifier, Cytonuclear | HALO |
p53 is associated with high-risk and pinpoints TP53 missense mutations in mantle cell lymphoma | Rodrigues JM, Hassan M, Freiburghaus C, Eskelund CW, Geisler C, Raty R, Kolstad A, Sundstrom C, Glimelius I, Gronbaek K, Kwiecinska A, Porwit A, Jerkeman M, Ek S | 2020 | British Journal of Haematology | Oncology | Classifier, Cytonuclear | HALO |
RUNX1 is a driver of renal cell carcinoma correlating with clinical outcome | Rooney N, Mason SM, McDonald L, Däbritz HM, Campbell KJ, Hedley A, Howard S, Athineos D, Nixon C, Clark W, Leach JDG, Samsom OJ, Edwards J, Cameron ER, Blyth K | 2020 | Cancer Research | Oncology | Cytonuclear | HALO |
Analytical Performance of an Immunoprofiling Assay Based on RNA Models | Schillebeeckx I, Armstrong JR, Forys JT, Hiken J, Earls J, Flanagan KC, Cui T, Glasscock JI, Messina DN, Duncavage EJ | 2020 | The Journal of Molecular Diagnostics | Immunology | Cytonuclear | HALO |
Prognostic significance of mesothelin expression in colorectal cancer disclosed by area-specific four-point tissue microarrays | Shiraishi T, Shinto E, Nearchou IP, Tsuda H, Kajiwara Y, Einama T, Caie PD, Kishi Y, Ueno H | 2020 | Vichows Archiv | Oncology | Cytonuclear, TMA | HALO AI |
Prognostic and Predictive Value of Tumor-infiltrating Leukocytes and of Immune Checkpoint Molecules PD1 and PDL1 in Clear Cell Renal Cell Carcinoma | Stenzel PJ, Schindeldecker M, Teagscherer KE, Foersch S, Herpel E, Hohenfellner M, Hatiboglu G, Alt J, Thomas C, Haferkamp A, Roth W, Macher-Goeppinger S | 2020 | Translational Oncology | Oncology, Immuno-oncology | Classifier, Cytonuclear, TMA | HALO |
Linking epigenetic signature and metabolic phenotype in IDH mutant and IDH wildtype diffuse glioma | Buran Y, Filipski K, Bernatz S, Baumgarten P, Roller B, Zinke J, Zeiner PS, Ilina E, Senft C, Ronellenfitsch MW, Plate KH, Bähr O, Hattingen E, Steinbach JP, Mittelbron M, Harter PN | 2020 | Neuropathology and Applied Neurobiology | Neuroscience | Multiplex IHC, TMA | HALO |
O 6-Methylguanine DNA Methyltransferase and Glucose Transporter 2 in Foregut and Hindgut Gastrointestinal Neuroendocrine Neoplasms | Watanbe H, Yamazaki Y, Fujishima F, Izxumi K, Imamura M, Hijioka S, Toriyama K, Yatabe Y, Kudo A, Motoi F, Unno M, Sasano H | 2020 | BMC Cancer | Oncology | Cytonuclear | HALO |
SLFN11 informs on standard of care and novel treatments in a wide range of cancer models | Winkler C, Armenia J, Jones GN, Tobalina L, Sale MJ, Petreus T, Baird T, Serra V, Wang AT, Lau A, Garnett MJ, Jaaks P, Coker EA, Pierce AJ, O'Connor MJ, Leo E | 2020 | British Journal of Cancer | Oncology | Classifier, Cytonuclear | HALO |
Lung Expression of Human ACE2 Sensitizes the Mouse to SARS-CoV-2 Infection | Han K, Blair RV, Iwanaga N, Liu F, Russell-Lodrigue KE, Qin Z, Midkiff CC, Golden NA, Doyle-Meyers LA, Kabir ME, Chandler KE, Cutrera KL, Ren M, Monjure CJ, Lehmicke G, Fischer T, Beddingfield B, Wanek AG, Birnbaum A, Maness NJ, Roy CJ, Datta PK, Rappaport J, Kolls JK, Qin X | 2020 | American Journal of Respiratory Cell and Molecular Biology | Infectious Disease | HALO AI | |
Human ileal organoid model recapitulates clinical incidence of diarrhea associated with small molecule drugs | Belair DG, Visconti RJ, Hong M, Marella M, Peters MF, Scott CW, Kolaja KL | 2020 | Toxicology in Vitro | Toxicology | Highplex FL | HALO |
Multiomic analysis and immunoprofiling reveal distinct subtypes of human angiosarcoma | Chan JY, Lim JQ, Yeong J, Ravi V, Guan P, Boot A, Tay TKY, Selvarajan S, Nasir NDM, Loh JH, Ong CK, Huang D, Tan J, Li Z, Ng CC-Y, Tan TT, Masuzawa M, Sung KW-K, Farid M, Quek RHH, Tan NC, Teo MCC, Rozen SG, Tan P, Fotreal A, The BT, Soo KC | 2020 | The Journal of Clinical Investigation | Immuno-oncology | Highplex FL | HALO |
Tumoral PD-1hiCD8+ 1 T cells are partially exhausted and 2 predict favorable outcome in triple-negative breast cancer | Guo L, Cao C, Goswami S, Huang X, Ma L, Guo Y, Yang B, Li T, Chi Y, Zhang X, Wu J | 2020 | Clinical Science | Immuno-oncology | Highplex FL | HALO |
CXCR4+ cells are increased in lung tissue of patients with idiopathic pulmonary fibrosis | Jaffar J, Griffiths K, Oveissi S, Duan M, Foley M, Glaspole I, Symons K, Organ L, Westfall G | 2020 | Respiratory Research | Fibrosis | Highplex FL | HALO |
Rova-T enhances the anti-tumor activity of anti-PD1 in a murine model of small cell lung cancer with endogenous Dll3 expression | Vitorino P, Chuang C-H, Iannello Z, Zhao X, Anderson W, Ferrando R, Zhang Z, Madhavan S, Karsunky H, Saunders LR | 2020 | Translational Oncology | Immuno-oncology | Highplex FL | HALO |
Safety, immunogenicity, and clinical efficacy of durvalumab in combination with folate receptor alpha vaccine TPIV200 in patients with advanced ovarian cancer: a phase II trial | Zamarin D, Walderich S, Holland A, Zhou Q, Iasonos AE, Torrisi JM, Merghoub T, Chesebrough LF, Mcdonnell AS, Gallagher JM, Li Y, Hollmann TJ, Grisham RN, Erskine CL, Block MS, Knutson KL, O'Cearbhaill RE, Aghajanian C, Konner JA | 2020 | Journal for ImmunoTherapy of Cancer | Immuno-oncology | Highplex FL | HALO |
Trajectory and Functional Analysis of PD-1high CD4+CD8+ T Cells in Hepatocellular Carcinoma by Single-Cell Cytometry and Transcriptome Sequencing | Zheng B, Wang D, Qiu X, Luo G, Wu T, Yang S, Li Z, Zhu Y, Wang S, Wu R, Sui C, Gu Z, Shen S, Jeong S, Wu Z, Gu J, Wang H, Chen L | 2020 | Advanced Science | Immuno-oncology | Highplex FL | HALO |
Pulmonary Mycobacterium tuberculosis control associates with CXCR3- and CCR6-expressing antigen-specific Th1 and Th17 cell recruitment | Shanmugasundaram U, Bucsan AN, Ganatra SR, Ibegbu C, Quezada M, Blair RV, Alvarez X, Velu V, Kaushal D, Rengarajan J | 2020 | JCI Insight | Infectious Disease | Highplex FL | HALO AI |
A first-in-human, phase 1, dose-escalation study of ABBV-176, an antibody-drug conjugate targeting the prolactin receptor, in patients with advanced solid tumors | Lemech C, Woodward N, Chan N, Mortimer J, Naumovski L, Nuthalapati S, Tong B, Jiang F, Ansell P, Ratajczak CK, Sachdev J | 2020 | Investigational New Drugs | Oncology | ISH/FISH | HALO |
Gene expression of prostaglandin EP4 receptor in three canine carcinomas | Musser ML, Viall AK, Phillips RL, Hostetter JM, Johannes CM | 2020 | BMC Veterinary Research | Oncology | ISH/FISH | HALO |
Cholecystokinin-1 receptor agonist induced pathological findings in the exocrine pancreas of non-human primates | Nyborg NCB, Kirk RK, de Boer AS, Andersen DW, Bugge A, Wulff BS, Thorup I, Clausen TR | 2020 | Toxicology & Applied Pharmacology | Metabolism | ISH/FISH | HALO |
NPY mediates the rapid feeding and glucose metabolism regulatory functions of AgRP neurons | Ruud LE, Pereira MMA, de Solis AJ, Fenselau H, Bruning JC | 2020 | Nature Communications | Metabolism | ISH/FISH | HALO |
Age-determined expression of priming protease TMPRSS2 and localization of SARS-CoV-2 infection in the lung epithelium | Schuler BA, Habermann AC, Plosa EJ, Taylor CJ, Jetter C, Kapp ME, Benjamin JT, Gullerman P, Nichols DS, Braunstein LZ, Hackett A, Koval M, Guttentag SH, Blackwell TS, Webber SA, Banovich NE, Kropski JA, Sucre JMS | 2020 | The Journal of Clincial Invesitgation | Infectious Disease | ISH/FISH | HALO |
STAT3 inhibition with galiellalactone efectively targets the prostate cancer stem?like cell population | Canesin G, Maggio V, Palominos M, Stiehm A, Contreras HR, Castellon EA, Morote J, Paciucci R, Maitland NJ, Bjartell A, Hellsten R | 2020 | Scientific Reports | Oncology | Membrane | HALO |
Genetic alterations and expression characteristics of ARID1A impact tumor immune contexture and survival in early-onset gastric cancer | Zou J, Qin W, Wang L, Wang Y, Shen J, Xiong W, Yu S, Song S, Ajani JA, Lin S-Y, Mills GB, Yuan X, Chen J, Peng G | 2020 | American Journal of Cancer Research | Immuno-oncology | Spatial Analysis, Highplex FL | HALO |
Computational image analysis of T-cell infiltrates in resectable gastric cancer: association with survival and molecular subtypes | Challoner BR, von Loga K, Woolston A, Griffiths B, Sivamanoharan N, Semiannikova M, Newey A, Barber LJ, Mansfield D, Hewitt LC, Saito Y, Davarzani N, Starling N, Melcher A, Grabsch HI, Gerlinger M | 2020 | JNCI: Journal of the National Cancer Institute | Immuno-oncology | Multiplex IHC | HALO |
Temporal and Spatial Heterogeneity of Host Response to SARS-CoV-2 Pulmonary Infection | Desai N, Neyaz A, Szabolcs A, Shih AR, Chen JH, Thapar V, Nieman LT, Solovyov A, Mehta A, Lieb DJ, Kulkarni AS, Jaicks C, Pinto CJ, Juric D, Chebib I, Colvin RB, Kim AY, Monroe R, Warren SE, Danaher P, Reeves JW, Gong J, Rueckert EH, Greenbaum BD, Hacohen N, Lagana SM, Rivera MN, Sholl LM, Stone JR, Ting DT, Deshpande V | 2020 | medRxiv | Infectious Disease | Multiplex IHC | HALO |
An Antibody Targeting ICOS Increases Intratumoral Cytotoxic to Regulatory T-cell Ratio and Induces Tumor Regression | Sainson RCA, Thotakura AK, Kosmac M, Borhis G, Parveen N, Kimber R, Carvalho J, Henderson SJ, Pryke KL, Okell T, O'Leary S, Ball S, Van Krinks C, Gamand L, Taggart E, Pring EJ, Ali H, Craig H, Wong VWY, Liang Q, Rowlands RJ, Lecointre M, Campbell J, Kirby I, Melvin D, Germaschewski V, Oelmann E, Quaratino S, McCourt M | 2020 | Cancer Immunology Research | Immuno-oncology | Multiplex IHC | HALO |
Immunogradient Indicators for Antitumor Response Assessment by Automated Tumor-Stroma Interface Zone Detection | Rasmusson A, Zilenaite D, Nestarenkaite A, Augulis R, Laurinaviciene A, Ostapenko V, Poskus T, Laurinavicius A | 2020 | The American Journal of Pathology | Multiplex IHC | HALO AI | |
Neoadjuvant immunotherapy leads to pathological responses in MMR-proficient and MMR-deficient early-stage colon cancers | Chalabi M, Fanchi LF, Dijkstra KK, Van den Berg JG, Aalbers AG, Sikorska K, Lopez-Yurda M, Grootscholten C, Beets GL, Snaebjornsson P, Maas M, Mertz J, Veninga V, Bounova G, Broeks A, Beets-Tan RG, de Wijkerslooth TR, van Lent AU, Marsman HA, Nuijten E, Kok NF, Kuiper M, Verbeek WH, Kok M, Van Leerdam ME, Schumacher TN, Voest EE, Haanen JB | 2020 | Nature Medicine | Immuno-oncology | Multiplex IHC, Serial Section | HALO |
MCL1 inhibition is effective against a subset of small-cell lung cancer with high MCL1 and low BCL-XL expression | Yasuda Y, Ozasa H, Kim YH, Yamazoe M, Ajimizu H, Funazo TY, Nomizo T, Tsuji T, Yoshida H, Sakamori Y, Najajima N, Menju T, Yoshizawa A, Date H, Hirai T | 2020 | Cell Death & Disease | Oncology, Immuno-oncology | Cytonuclear | HALO |
Inhibition of myostatin prevents microgravity-induced loss of skeletal muscle mass and strength | Smith RC, Cramer MS, Mitchell PJ, Lucchesi J, Ortega AM, Livingston EW, Ballard D, Zhang L, Hanson J, Barton K, Berens S, Credille KM, Bateman TA, Ferguson VL, Ma YL, Stodieck LS | 2020 | PLOS One | Myology | Muscle Fiber | HALO |
Photoacoustic imaging biomarkers for monitoring biophysical changes during nanobubble-mediated radiation treatment | Hysi E, Fadhel MN, Wang Y, Sebastian JA, Giles A, Czarnota GJ, Exner AA, Kolios MC | 2020 | Photoacoustics | Other | Classifier, Area Quantification, Object Colocalization | HALO |
Single-cell analysis of germinal-center B cells informs on lymphoma cell of origin and outcome | Holmes AB, Corinaldesi C, Shen Q, Kumar R, Compagno N, Wang Z, Nitzan M, Grunstein E, Pasqualucci L, Dalla-Favera R, Basso K | 2020 | Journal of Experimental Medicine | Oncology | Registration | HALO |
Artificial intelligence as the next step towards precision pathology | Acs B, Rantalainen M, Hartman J | 2020 | Journal of Internal Medicine | Review | HALO | |
Ngly1?/? rats develop neurodegenerative phenotypes and pathological abnormalities in their peripheral and central nervous systems | Asahina M, Fujinawa R, Nakamura S, Yokoyama K, Tozawa R, Suzuki T | 2020 | Human Molecular Genetics | HALO | ||
Consumptive coagulopathy of severe yellow fever occurs independently of hepatocellular tropism and massive hepatic injury | Baileya AL, Kanga L-I, Zanellab LGFdABD, Silveirab CGT, Hod Y-H, Foquete L, Biale G, McCunef BT, Duarte-Netog AN, Thomash A, Rauéh H-P, Byrnesa K, Kallasd EG, Slifkah MK, Diamond MS | 2020 | Proceedings of the National Academy of Sciences | Infectious Disease | HALO | |
?-Synuclein modulates tau spreading in mouse brains | Bassil F, Meymand ES, Brown HJ, Xu H, Cox TO, Pattabhiraman S, Maghames CM, Wu Q, Zhang B, Trojanowski JQ, Lee VM-Y | 2020 | Journal of Experimental Medicine | Neuroscience | HALO | |
Ad26 vaccine protects against SARS-CoV-2 severe clinical disease in hamsters | Tostanoski LH, Wegmann F, Martinot AJ, Loos C, McMahan K, Mercado NB, Yu J, Chan CN, Bondoc S, Starke CE, Nekorchuk M, Busman-Sahay K, Piedra-Mora C, Wrijil LM, Ducat S, Custers J, Atyeo C, Fischinger S, Burke JS, Feldman J, Hauser BM, Caradonna TM, Bondzie EA, Dagotto G, Gebre MS, Jacob-Dolan C, Lin Z, Mahrokhian SH, Nampanya F, Nityanandam R, Pessaint L, Porto M, ALi V, Benetiene D, Tevi K, Andersen H, Lewis MG, Schmidt AG, Lauffenburger DA, Alter G, Estes JD, Schuitemaker H, Zahn R, Barouch DH | 2020 | Nature Medicine | Infectious Disease | Area Quantification, Multiplex IHC | HALO |
Prognostic relevance of programmed cell death protein 1/programmed death-ligand 1 pathway in thymic malignancies with combined immunohistochemical and biomolecular approach | Berardi R, Goteri G, Brunelli A, Pagliaretta S, Paolucci V, Caramanti M, Rinaldi S, Refai M, Pompili C, Morgese F, Torniai, Marcantognini, Ricci G, Mazzanti P, Onofri A, Bianchi F, Sabbatini A, Cascinu S | 2020 | Expert Opinion on Therapeutic Targets | Oncology | HALO | |
Liraglutide treatment improves endothelial function in the Ldlr?/? mouse model of atherosclerosis and affects genes involved in vascular remodelling and inflammation | Bjørnholm KD, Skovsted GF, Mitgaard-Thomsen A, Rakipovski G, Tveden-Nyborg P, Lykkesfeldt J, Povlsen GK | 2020 | Basic & Clinical Pharmacology & Toxicology | Immunology, Toxicology | HALO | |
Microglial-associated responses to comorbid amyloid pathology and hyperhomocysteinemia in an aged knock-in mouse model of Alzheimerís disease | Braun DJ, Dimayuga E, Morganti JM, Van Eldik LJ | 2020 | Journal of Neuroinflammation | Neuroscience | HALO | |
Glucagon Receptor Inhibition Reduces Hyperammonemia and Lethality in Male Mice with Urea Cycle Disorder | Cavino K, Sung B, Su Q, Na E, Kim J, Cheng X, Gromada J, Okamoto H | 2020 | Endocrinology | Metabolism | HALO | |
Immune parameters associated with survival in metaplastic breast cancer | Chao X, Liu L, Sun P, Yang X, Li M, Luo R, Huang Y, He J, Yun J | 2020 | Breast Cancer Research | Immuno-oncology | HALO | |
Alterations in Intestinal Innate Mucosal Immunity of Weaned Pigs During Porcine Epidemic Diarrhea Virus Infection | Chen Y-M, Helm ET, Gabler N, Hostetter JM, Burrough ER | 2020 | Veterinary Pathology | Infectious Disease | HALO | |
Expression of the Autoantigen Topoisomerase-1 is Enriched in the Lung Tissues of Patients With Autoimmune Interstitial Lung Disease: A Case Control Study | Cottrell TR, Askin F, Halushka MK, Casciola-Rosen L, McMahan ZH | 2020 | ACR Open Reumatology | Immunology | HALO | |
Growth Factor Receptor Expression in Oropharyngeal Squamous Cell Cancer: Her14 and c-Met in Conjunction with the Clinical Features and Human Papillomavirus (p16) Status | Deuss E, Gößwein D, Gül D, Zimmer S, Foersch S, Eger CS, Limburg I, Stauber RH, Künzel J | 2020 | Cancers | Oncology | HALO | |
Formoterol, a ?2-adrenoreceptor agonist, induces mitochondrial biogenesis and promotes cognitive recovery after traumatic brain injury | Vekaria HJ, Hubbard WB, Scholpa NE, Spry ML, Gooch JL, Prince SJ, Schnellmann Sullivan PG | 2020 | Neurobiology of Disease | Neuroscience | Area Quantification | HALO |
Deep Brain Stimulation of the Medial Septal Nucleus Induces Expression of a Virally Delivered Reporter Gene in Dentate Gyrus | Fomenko A, Lee DJ, McKinnon C, Lee EJ, de Snoo ML, Gondard E, Neudorfer C, Hamani C, Lozano AM, Kalia LV, Kalia SK | 2020 | Frontiers of Neuroscience | Neuroscience | HALO | |
The membrane protein sortilin can be targeted to inhibit pancreatic cancer cell invasion | Gao F, Griffin N, Faulkner S, Li X, King SJ, Jobling P, Denham JW, Jiang CC, Hondermarck H | 2020 | The American Journal of Pathology | Oncology | HALO | |
Neoadjuvant PD-L1 plus CTLA-4 blockade in patients with cisplatin-ineligible operable high-risk urothelial carcinoma | Gao J, Navai N, Alhalabi O, Siefker-Radtke A, Campbell MT, Tidwell RS, Guo CC, Kamat AM, Matin SF, Araujo CJ, Shah AY, Msaouel P, Corn P, Wang J, Papadopoulos JN, Yadav SS, Blando JM, Duan F, Basu S, Liu W, Shen Y, Macaluso MD, Wang Y, Chen J, Zhang J, Futreal A, Dinney C, Allison JP, Goswami S, Sharma P | 2020 | Nature Medicine | Toxicology | HALO | |
Intratumoral heterogeneity of the tumor cells based on in situ cortisol excess in cortisol-producing adenomas; An association among morphometry, genotype and cellular senescence | Gao X, Yamazaki Y, Tezuka Y, Pieroni J, Ishii K, Atsumi N, Ono Y, Omata K, Morimoto R, Nakamura Y, Satoh F, Sasano H | 2020 | The Journal of Steroid Biochemistry and Molecular Biology | Oncology | HALO | |
Nicotinic Receptor Subunit Distribution in Auditory Cortex: Impact of Aging on Receptor Number and Function | Ghimire M, Cai R, Ling L, Hackett TA, Caspary DM | 2020 | Journal of Neuroscience | Neuroscience | HALO | |
Acute brain inflammation, white matter oxidative stress, and myelin deficiency in a model of neonatal intraventricular hemorrhage | Goulding DS, Vogel RC, Gensel JC, Morganti JM, Stromberg AJ, Miller BA | 2020 | Journal of Neuroscience | Immunology, Neuroscience | HALO | |
Neonatal hydrocephalus leads to white matter neuroinflammation and injury in the corpus callosum of Ccdc39 hydrocephalic mice | Goulding DS, Vogel RC, Pandya CD, Shula C, Gensel JC, Mangano FT, Goto J, Miller BA | 2020 | Journal of Neurosurgery | Immunology, Neuroscience | HALO | |
Quantification of Viral and Host Biomarkers in the Liver of Rhesus Macaques: a Longitudinal Study of Zaire Ebolavirus strain Kikwit (EBOV/Kik) | Greenberg AR, Huber BR, Liu DX, Logue JP, Hischak AMW, Hart RJ, Abbott M, Isic N, Hisada YM, Mackman N, Bennet RS, Hensley LE, Connor JH, Crossland NA | 2020 | The American Journal of Pathology | HALO | ||
Clinicopathological significance of nerves in esophageal cancer | Griffin N, Rowe CW, Gao F, Jobling P, Wills V, Walker MM, Faulkner S, Hondermarck H | 2020 | The American Journal of Pathology | Oncology | HALO | |
The human IL-15 superagonist N-803 promotes migration of virus-specific CD8+ T and NK cells to B cell follicles but does not reverse latency in ART-suppressed, SHIV-infected macaques | Webb GM, Molden J, Bushman-Sahay K, Abdulhaqq S, Wu HL, Weber WC, Bateman KB, Reed JS, Northrup M, Maier N,Tanaka S, Gao L, Davey B, Carpenter BL, Axthelm MK, Stanton JJ, Smedley J, Greene JM, Safrit JT, Estes JD, Skinner PJ, Sacha JB | 2020 | PLOS Pathogens | Infectious Disease | Cytonuclear, ISH/FISH | HALO |
Neonatal therapy with PF543, a sphingosine kinase 1 inhibitor, ameliorates hyperoxia-indused airway remodeling in a murine model of bronchopulmonary dysplasia | Ha AW, Sudhadevi T, Ebenezeer DL, Fu P, Berdyshev EV, Ackerman SJ, Natarajan V, Harijith A | 2020 | American Journal of Physiology | Other | HALO | |
Investigating Radiotherapy Response in a Novel Syngeneic Model of Prostate Cancer | Haughey CM, Mukherjee D, Steele RE, Popple A, Dura-Perez L, Pickard A, Patel M, Jain S, Mullan PB, Williams R, Oliveira P, Buckley NE, Honeychurch J, McDade SS, Illidge T, Mills IG, Eddie SL | 2020 | Cancers | Oncology | HALO | |
Intratumoral interleukin-12 mRNA therapy promotes TH1 transformation of the tumor microenvironment | Hewitt SL, Bailey D, Zielinski J, Apte A, Musenge F, Karp R, Burke S, Garcon F, Mishra A, Gurumurthy S, Watkins A, Arnold K, Moynihan J, Clancy-Thompson E, Mulgrew K, Adjei G, Deschler K, Potz D, Moody G, Leinster DA, Novick S, Sulikowski M, Bagnall CJ, Martin P, Lapointe J-M, Si H, Morehouse CA, Sedic M, Wilkinson RW, Herbst R, Frederick JP, Luheshi N | 2020 | Clinical Cancer Research | Immuno-oncology | HALO | |
IFN-III is selectively produced by cDC1 and predicts good clinical outcome in breast cancer | Hubert M, Gobbini E, Couillault C, Manh T-PV, Doffin A-C, Berthet J, Rodriguez C, Ollion V, Kielbassa J, Sajous C, Treilleux I, Tredan O, Dubois B, Dalod M, Bendriss-Vermare N, Caux C, Valladeau-Guilemond J | 2020 | Immunology | HALO | ||
PNOCARC Neurons Promote Hyperphagia and Obesity upon High-Fat-Diet Feeding | Jais A, Paeger L, Sotelo-Hitschfeld T, Bremser S, Prinzensteiner M, Klemm P, Mykytiuk V, Widdershooven PJM, Vesting AJ, Grzelka K, Minere M, Cremer AL, Xu J, Korotkova T, Lowell BB, Zeilhofer HU, Backes H, Fenselau H, Wunderlich FT, Kloppenburg P, Bruning JC | 2020 | Neuron | Neuroscience | HALO | |
Tutorial: guidance for quantitative confocal miscroscopy | Jonkman J, Brown CM, Wright GD, Anderesion KI, North AJ | 2020 | Nature Protocols | HALO | ||
Omental macrophages secrete chemokine ligands that promote ovarian cancer colonization of the omentum via CCR1 | Krishnan V, Tallapragada S, Schaar B, Kamat K, Chanana AM, Zhang Y, Patel S, Parkash V, Rinker-Schaeffer C, Folkins AK, Rankin EB, Dorigo O | 2020 | Communications Biology | Oncology | HALO | |
A drug-induced hypotensive challenge to verify catheter-based radiofrequency renal denervation in an obese hypertensive swine model | Lauder L, Moon LB, Pipenhagen CA, Ewen S, Fish JM, Virmani R, Jensen JA, Böhm M, Mahfoud F | 2020 | Clinical Research in Cardiology | Myology | HALO | |
The identification and functional analysis of CD8+PD-1+CD161+ T cells in hepatocellular carcinoma | Li Z, Zheng B, Qiu X, Wu R, Wu T, Yang S, Zhu Y, Wu X, Wang S, Gu Z, Shen S, Wu M, Wang H, Chen L | 2020 | Percision Oncology | Immuno-oncology | HALO | |
The diagnostic and prognostic value of UBE2T in intrahepatic cholangiocarcinoma | Yu H, Wang H, Dong W, Cao Z-Y, Li R, Yang C, Cong W-M, Dong H, Jin G-Z | 2020 | Peer J | Oncology | Cytonuclear | HALO |
Degradation of the Tumor Suppressor PDCD4 Is Impaired by the Suppression of p62/SQSTM1 and Autophagy | Manirujjaman M, Ozaki I, Murata Y, Guo J, Xia J, Nishioka K, Perveen R, Takashashi H, Anzai K, Matsuhashi S | 2020 | Cells | Oncology | HALO | |
Robust and persistent reactivation of SIV and HIV by N-803 and depletion of CD8+ cells | McBrien JB, Mavigner M, Li LF, Smith SA, White E, Tharp GK, Walum H, Busman-Suhay K, Aguilera-Sandoval CR, Thayer WO, Spagnuolo RA, Kovarova M, Wahl A, Cervasi B, Margolis DM, Vanderford TH, Carnathan DG, Paiardini M, Lifson JD, Lee JH, Safrit JT, Bosinger SE, Estes JD, Derdeyn CA, Garcia JV, Kulpa DA, Chahroudi A, Silvestri G | 2020 | Nature | HALO | ||
Early-onset impairment of the ubiquitin-proteasome system in dopaminergic neurons caused by ?-synucleinn | McKinnon C, De Snoo ML, Gondard E, Neudorfer C, Chau H, Ngana SG, O'Hara DM, Brotchie JM , Koprich JB, Lozano AM, Kalia LV, Kalia SK | 2020 | Acta Neuropathologica Communications | Neuroscience | HALO | |
A Dedicated Evolutionarily Conserved Molecular Network Licenses Differentiated Cells to Return to the Cell Cycle | Miao Z-F, Lewis MA, Cho CJ, Adkins-Threats M, Park D, Brown JW, Sun J-X, Burclaff JR, Kennedy S, Lu J, Mahar M, Vietor I, Huber LA, Davidson NO, Cavalli V, Rubin DC, Wang Z-N, Mills JC | 2020 | Developmental Cell | HALO | ||
The Unfolded Protein Response Mediator PERK Governs Myeloid Cell-Driven Immunosuppression in Tumors through Inhibition of STING Signaling | Mohamed E, Sierra RA, Trillo-Tinoco J, Cao Y, Innamarato P, Payne KK, Pulido M, Mandula J, Zhang S, Thevenot P, Biswas S, Abdalla SK, Costich TL, Hanggi K, Anadon CM, Flores ER, Haura EB, Mehrotra, Pilon-Thomas S, Ruffel B, Munn DH, Cubillos-Ruiz JR, Conejo-Garcia JR, Rodriguez PC | 2020 | Immunity | Immuno-oncology | HALO | |
CD137 agonist-based combination immunotherapy enhances activated, effector memory T cells and prolongs survival in pancreatic adenocarcinoma | Muth ST, Saung MT, Blair AB, Henderson MG, Thomass DL II, Xheng L | 2020 | Cancer Letters | Immuno-oncology | HALO | |
Immunohistochemical scoring of CD38 in the tumor microenvironment predicts responsiveness to anti-PD-1/PD-L1 immunotherapy in hepatocellular carcinoma | Ng HHM, Lee RY, Goh S, Tay ISY, Lim X, Lee B, Chew V, Li H, Tan B, Lim S, Lim JCT, Au B, Loh JJH, Saraf S, Connolly JE, Loh T, Leow WQ, Lee JJX, Toh HC, Malavasi F, Lee SY, Chow P, Newell EW, Choo SP, Tai D, Yeong J, Lim TKH | 2020 | Journal for ImmunoTherapy of Cancer | Immuno-oncology | HALO | |
Features of increased malignancy in eosinophilic clear cell renal cell carcinoma | Nilsson H, Lindgren D, Axelson H, Brueffer C, Saal LH, Lundgren J, Johansson ME | 2020 | Journal of Pathology | Immuno-oncology | HALO | |
Antitumor Activity of Eribulin After Fulvestrant Plus CDK4/6 Inhibitor in Breast Cancer Patient-derived Xenograft Models | Niwa Y, Asano M, Nakagawa T, France D, Semba T, Funahashi Y | 2020 | Anticancer Research | Oncology | HALO | |
A Fas-4-1BB fusion protein converts a death to a pro-survival signal and enhances T cell therapy | Oda SK, Andereson KG, Ravikumar P, Bonson P, Garcia NM, Jenkins CM, Zhuang S, Daman A, Chiu EY, Bates BM, Greenberg PD | 2020 | Journal of Experimental Medicine | Immuno-oncology | HALO | |
The Arp2/3 complex is crucial for colonisation of the mouse skin by melanoblasts | Papalazarou V, Swaminathan K, Jaber-Hijaz Fi, Spence H, Lahmann I, Nixon C, Salmeron-Sanchez M, Arnold H-H, Rottner K, Machesky LM | 2020 | Development | Review | HALO | |
Incomplete Freunds adjuvant reduces arginase and enhances Th1 dominance, TLR signaling and CD40 ligand expression in the vaccine site microenvironment | Pollack KE, Meneveau MO, Melssen MM, Lynch KT, Koeppel AF, Young SJ, Turner S, Kumar P, Sol-Church K, Mauldin IS, Slingfluff CL | 2020 | Journal for ImmunoTherapy of Cancer | Immuno-oncology | HALO | |
Senescence, Necrosis, and Apoptosis Govern Circulating Cell-free DNA Release Kinetics | Rostami A, Lambie M, Yu CW, Stambolic V, Waldron JN, Bratman SV | 2020 | Cell Reports | Toxicology | HALO | |
Discoidin Domain Receptor 1 (DDR1) is Necessary for Tissue Homeostasis in Pancreatic Injury and Pathogenesis of Pancreatic Ductal Adenocarcinoman | Ruggeri JM, Franco-Barraza J, Sohail A, Zhang Y, Long D, di Magliano MP, Cukierman E, Fridman R, Crawford HC | 2020 | The American Journal of Pathology | Oncology, Immunology | HALO | |
Natural killer cells in the human lung tumor microenvironment display immune inhibitory functions | Russick J, Joubert P-E, Gillard-Bocquet M, Torset C, Meylan M, Petitprez F, Dragon-Durey M-A, Marmier S, Varthaman A, Josseaume N, Germain C, Jérémy Goc J, Dieu-Nosjean M-C, Validire P, Fournel L, Zitvogel L, Bindea G, Lupo A, Damotte D, Alifano M, Cremer I | 2020 | Journal for ImmunoTherapy of Cancer | Immuno-oncology | HALO | |
A potent peptide-steroid conjugate accumulates in cartilage and reverses arthritis without evidence of systemic corticosteroid exposure | Sanger MLC, Girard EJ, Hopping G, Yin C, Pakiam F, Brusniak M-Y, Nguyen E, Ruff R, Gewe MM, Byrnes-Blake K, Nairn NW, Miller DM, Mehlin C, Strand AD, Mhyre AJ, Correnti CE, Strong RK, Simon JA, Olson JM | 2020 | Science Translational Medicine | Immunology | HALO | |
Intratumoral Combinatorial Administration of CD1c (BDCA-1) + Myeloid Dendritic Cells Plus Ipilimumab and Avelumab in Combination with Intravenous Low-Dose Nivolumab in Patients with Advanced Solid Tumors: A Phase IB Clinical Trial | Schwarze JK, Awada G, Cras L, Tijtgat J, Forsyth R, Dufait I, Tuyaerts S, Riet VI, Neyns B | 2020 | Vaccines | Immuno-oncology | HALO | |
IL6/STAT3 Signaling Hijacks Estrogen Receptor ? Enhancers to Drive Breast Cancer Metastasis | Siersbæk R, Scabia V, Nagarajan S, Chernukhin I, Papachristou EK, Broome R, Johnston SJ, Joosten SEP, Green AR, Kumar S, Jones J, Omarjee S, Alvarez-Fernandez R, Glont S, Aitken SJ, Kishore K, Cheeseman D, Rakha EA, D'Santos C, Zwart W, Ruseel A, Brisken C, Carroll JS | 2020 | Cancer Cell | Oncology | HALO | |
GSTO1?1 is an upstream suppressor of M2 macrophage skewing and HIF?1??induced eosinophilic airway inflammation/a> | Sokulsky LA, Goggins B, Sherwin S, Eyeers F, Kaiko GE, Board PG, Keely S, Yang M, Foster PS | 2020 | Clinical & Experimental Allergy | Immunology | HALO | |
Neoantigen responses, immune correlates, and favorable outcomes after ipilimumab treatment of patients with prostate cancer | Subudhi SK, Vence L, Zhao H, Blando J, Yadav SS, Xiong Q, Reuben A, Aparicio A, Corn PG, Chapin BF, Pisters LL, Troncoso P, Tidwell RS, Thall P, Wu C-J, Zhang J, Logothetis CL, Futreal A, Allison JP, Sharma P | 2020 | Cancer | HALO | ||
Overview of multiplex immunohistochemistry/immunofluorescence techniques in the era of cancer immunotherapy | Tan WCCT, Nerurkar SN, Cai HY, Ng HHM, Wu D, Wee YTF, Lim JCT, Yeong J, Lim TKH | 2020 | Cancer Communications | Review | HALO | |
Association between CD8 and PD?L1 expression and outcomes after radical prostatectomy for localized prostate cancer | Vicier C, Ravi P, Kwak L, Werner L, Huang Y, Evan C, Loda M, Hamid AA, Sweeney CJ | 2020 | The Prostate | Immuno-oncology | HALO | |
Insoluble Tau From Human FTDP-17 Cases Exhibit Unique Transmission Properties In Vivo | Weitzman SA, Narasimhan S, He Z, Changolkar L, McBride JD, Zhang B, Schellenberg GD, Trojanowski JQ, Lee VMY | 2020 | Journal of Neuropathology & Experimental Neurology | Neuroscience | HALO | |
Engineering functional microvessels in synthetic polyurethane random-pore scaffolds by harnessing perfusion flow | Wright MEE, Yu JK, Jain D, Maeda A, Yeh S-CA, DaCosta RS, Lin CP, Santerre JP | 2020 | Biomaterials | HALO | ||
Neuronal activity modulates alpha-synuclein aggregation and spreading in organotypic brain slice cultures and in vivo | Wu Q, Shaikh MA, Meymand ES, Zhang B, Luk KC, Trojanowski JO, Lee VM-Y | 2020 | Acta Neuropathologica | Neuroscience | HALO | |
*A living biobank of matched pairs of patient-derived xenografts and organoids for cancer pharmacology | Xu X, Wang S, Zhou J, Chen J, Huang Y, Kumari R, Mao B, Zheng M, Wang J, Tu X, An X, Chen X, Zhang L, Tian X, Wang H, Dong X, Bao Z, Guo S, Ouyang X, Shan L, Wang F, Yan X, Li Z, Zhang R, Zhang H, Meiler S, Vries R, Clevers H | 2020 | *Pre-Print | Oncology | HALO | |
Safety and clinical activity of PD-L1 blockade in patients with aggressive recurrent respiratory papillomatosis | Allen CT, Lee S, Norberg SM, Kovalovsky D, Ye H, Clavijo PE, Hu-Lieskovan S, Schlegel R, Schlom J, Strauss J, Gulley JL, Trepel J, Hinrichs CS | 2019 | Journal for ImmunoTherapy of Cancer | Oncology, Immuno-oncology | Cytonuclear | HALO |
Cutaneous pharmacologic cAMP induction induces melanization of the skin and improves recovery from ultraviolet injury in melanocortin 1 receptor?intact or heterozygous skin | Bautista R-M, Carter KM, Jarrett SG, Napier D, Wakamatsu K, Ito S, D'Orazio JA | 2019 | Pigment Cell & Melanoma Research | Dermatology | Area Quantification | HALO |
Islet amyloidosis in a child with type 1 diabetes | Beery ML, Jacobsen LM, Atkinson MA, Butler AE, Campbell-Thompson M | 2019 | Islets | Metabolism | Classifier | HALO |
Predicting breast cancer response to neoadjuvant chemotherapy based on tumor vascular features in needle biopsies | Brocato TA, Brown-Glaberman U, Wang Z, Selwyn RG, Wilson CM, Wyckoff EF, Lomo LC, Saline JL, Hooda-Nehra A, Pasqualini R, Arap W, Brinker CJ, Cristini V | 2019 | JCI Insight | Oncology | Classifier | HALO |
Magnetic Resonance Imaging as a Biomarker in Rodent Peripheral Nerve Injury Models Reveals an Age-Related Impairment of Nerve Regeneration | Giorgetti E, Obrecht M, Ronco M, Panesar M, Lambert C, Accart N, Doelemeyer A, Nash M, Bidinosti M, Beckmann N | 2019 | Scientific Reports | Neuroscience | Classifier | HALO |
Unmasking of oestrogen?dependent changes in left ventricular structure and function in aged female rats: a potential model for pre?heart failure with preserved ejection fraction | Bustamante M, Garate?Carrillo A, Ito BR, Garcia R, Carson N, Ceballos G, Ramirez?Sanchez I, Omens J, Villarreal F | 2019 | The Journal of Physiology | Myology | Area Quantification, Layer Thickness | HALO |
MEDI3039, a novel highly potent tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) receptor 2 agonist, causes regression of orthotopic tumors and inhibits outgrowth of metastatic triple-negative breast cancer | Greer YE, Gilbert SF, Gril B, Narwal R, Brooks DLP, Tice DA, Steeg PS, Lipkowitz | 2019 | Breast Cancer Research | Oncology | Classifier | HALO |
Glucose-Dependent Insulinotropic Polypeptide Receptor-Expressing Cells in the Hypothalamus Regulate Food Intake | Adriaenssens AE, Biggs EK, Darwish T, Tadross J, Sukthankar T, Girish M, Polex-Wolf J, Lam BY, Zvetkova I, Pan W, Chiarugi D, Yeo GSH, Blouet C, Gribble FM, Reimann F | 2019 | Cell Metabolism | Metabolism | ISH/FISH | HALO |
Intravital imaging reveals systemic ezrin inhibition impedes cancer cell migration and lymph node metastasis in breast cancer | Ghaffari A, Hoskin V, Turashvili G, Varma S, Mewburn J, Mullins G, Greer PA, Kiefer F, Day AG, Madarnas Y, SenGupta S, Elliott BE | 2019 | Breast Cancer Research | Oncology | Classifier, Cytonuclear | HALO |
Modulation of Microglia by Voluntary Exercise or CSF1R Inhibition Prevents Age-Related Loss of Functional Motor Units | Giorgetti E, Panesar M, Zhang Y, Joller S, Ronco M, Obrecht M, Lambert C, Accart N, Beckmann N, Doelemeyer A, Perrot L, Fruh I, Mueller M, Pierrel E, Summermatter S, Bidinosti M, Shimshek DR, Brachat S, Nash M | 2019 | Cell Reports | Neuroscience | Classifier, Cytonuclear | HALO |
LLRRK2 inhibition does not impart protection from ?-synuclein pathology and neuron death in non-transgenic mice | Henderson MX, Sengupta M, McGeary I, Zhang B, Olufemi MF, Brown H, Trojanowski JQ, Lee VMY | 2019 | Acta Neuropathologica Communications | Neuroscience | Area Quantification, Cytonuclear | HALO |
Tumor Characteristics Associated with Benefit from Pembrolizumab in Advanced Non-Small Cell Lung Cancer | Hu-Lieskovan S, Lisberg A, Zaretsky JM, Grogan TR, Rizvi H, Wells DK, Carroll J, Cummings A, Madrigal J, Jones B, Gukasyan J, Shintaku IP, Slamon D, Dubinett S, Goldman JW, Elashoff D, Hellmann MD, Ribas A, Garon EB | 2019 | Clinical Cancer Research | Immuno-oncology | Cytonuclear | HALO |
Empiric Methods to Account for Pre-analytical Variability in Digital Histopathology in Frontotemporal Lobar Degeneration | Giannini LAA, Xie SX, Peterson C, Zhou C, Lee EB, Wolk DA, Grossman M, Trojanowski JQ, McMillan CT, Irwin DJ | 2019 | Frontiers in Neuroscience | Neuroscience | Area Quantification, Registration, Figure Maker | HALO |
Alterations of the MEK/ERK, BMP, and Wnt/?-catenin pathways detected in the blood of individuals with lymphatic malformations | Kim T, Tafoya E, Chelliah MP, Lekwuttikarn R, Li J, Sarin KY, Teng J | 2019 | PLOS One | Other | Cytonuclear | HALO |
Detection and quantification of Parascaris P-glycoprotein drug transporter expression with a novel mRNA hybridization technique | Chelladurai JJ, Brewer MT | 2019 | Veterinary Parasitology | Infectious Disease | ISH/FISH | HALO |
IL-7-dependent compositional changes within the ?? T cell pool in lymph nodes during ageing lead to an unbalanced anti-tumour response | Chen H-C, Eling N, Martinez-Jimenez CP, O'Brien LM, Carbonaro V, Marioni JC, Odom DT, de la Roche M | 2019 | EMBO Reports | Oncology, Immuno-oncology | ISH/FISH | HALO |
Assessment of PD-L1 mRNA and protein expression in non-small cell lung cancer, head and neck squamous cell carcinoma and urothelial carcinoma tissue specimens using RNAScope and immunohistochemistry | Duncan DJ, Scott M, Scorer P, Barker C | 2019 | PLOS One | Oncology, Immuno-oncology | ISH/FISH | HALO |
Expression of cholecystokinin by neurons in mouse spinal dorsal horn | Guitierrez-Mecinas M, Bell AM, Shepherd F, Polgar E, Watanabe M, Furuta T, Todd AJ | 2019 | The Journal of Comparitive Neurology | Neuroscience | ISH/FISH | HALO |
Methacrylic Acid Copolymer Coating Enhances Constructive Remodeling of Polypropylene Mesh by Increasing the Vascular Response | Coindre VF, Carleton MM, Sefton MV | 2019 | Advanced Healthcare Materials | Biomaterials | Area Quantification | HALO |
Cognitive and Pathological Influences of Tau Pathology in Lewy Body Disorders | Coughlin DG, Xie SX, Liang M, Williams A, Peterson C, Weintraub D, McMillan CT, Wolk DA, Akhtar RS, Hurtig H, Coslett HB, Hamilton R, Siderowf A, Duda JE, Rascovsky K, Lee EB, Lee VM-Y, Grossman M, Trojanowski JQ, Irwin DJ | 2019 | Annals of Neurology | Neuroscience | Classifier, Area Quantification | HALO |
CCN3/Nephroblastoma Overexpressed Is a Functional Mediator of Prostate Cancer Bone Metastasis That Is Associated with Poor Patient Prognosis | Dankner M, Ouellet V, Communal L, Schmitt E, Perkins D, Annis MG, Barrès V, Caron C, Mes-Masson A-M, Saad F, Siegel PM | 2019 | The American Journal of Pathology | Oncology | Area Quantification | HALO |
Divergent patterns of TDP?43 and tau pathologies in primary progressive aphasia | Giannini LAA, Xie SX, McMillan CT, Liang M, Williams A, Jester C, Rascovsky K, Wolk DA, Ash S, Lee EB, Trojanowski JQ, Grossman M, Irwin DJ | 2019 | Annals of Neurology | Neuroscience | Area Quantification | HALO |
Characterization of novel conformation-selective ?-synuclein antibodies as potential immunotherapeutic agents for Parkinson's disease | Henderson MX, Covell DJ, Chung C-HY, Pitkin RM, Sandler RM, Decker SC, Riddle DM, Zhang B, Gathagan RJ, James MJ, Trojanowski JQ, Brunden KR, Lee VMY, Luk KC | 2019 | Neurobiology of Disease | Neuroscience | Area Quantification | HALO |
Alzheimerís disease tau is a prominent pathology in LRRK2 Parkinsonís disease | Henderson MX, Sengupta M, Trojanowski JQ, Lee VMY | 2019 | Acta Neuropathologica Communications | Neuroscience | Area Quantification | HALO |
Lenvatinib induces death of human hepatocellular carcinoma cellsharboring an activated FGF signaling pathway through inhibition ofFGFReMAPK cascades | Hoshi T, Miyano SW, Watanabe H, Sonobe RMK, Seki Y, Ohta E, Nomoto K, Matsui J, Funahashi Y | 2019 | Biochemical and Biophysical Research Communications | Oncology | Area Quantification | HALO |
Molecular and functional heterogeneity of cancer associated fibroblasts in high-grade serous ovarian cancer | Hussain A, Voisin V, Poon S, Dmytryshyn J ,Richman C, Meens J, Ho VW, Tang KH, Paterson J, Clarke B, Bernardini M, Bader G, Neel B, Ailles L | 2019 | bioRxiv | Oncology | Classifier, Area Quantification | HALO |
Alzheimer Disease Pathology-Associated Polymorphism in a Complex Variable Number of Tandem Repeat Region Within the MUC6 Gene, Near the AP2A2 Gene | Katsumata Y, Fardo DW, Bachstetter AD, Artiushin SC, Wang W-X, Wei A, Brzezinski LJ, Nelson BG, Huang Q, Abner EL, Anderson S, Patel I, Shaw BC, Price DA, Niedowicz DM, Wilcock DW, Jicha GA, Neltner JH, Van Eldik LJ, Estus S, Nelson PT | 2019 | Journal of Neuropathology & Experimental Neurology | Neuroscience | Area Quantification, Cytonuclear | HALO |
IRAK4 mediates colitis-induced tumorigenesis and chemoresistance in colorectal cancer | Li Q, Chen Y, Zhang D, Grossman J, Li L, Khurana N, Jiang H, Grierson PM, Herndon J, DeNardo DG, Challen GA, Liu J, Ruzinova MB, Fields RC, Lim K-H | 2019 | JCI Insight | Oncology, Immuno-oncology | Area Quantification | HALO |
Dysregulated expression but redundant function of the long non-coding RNA HOTAIR in diabetic kidney disease | Majumder S, Hadden MJ, Thieme K, Batchu SN, Niveditha D, Chowdhury S, Yerra VG, Advani SL, Bowskill BB, Liu Y, Vakili H, Alghamdi TA, White KE, Geldenhuys L, Siddiqi FS, Advani A | 2019 | Diabetologia | Metabolism | Area Quantification | HALO |
Targeted drug delivery via caveolae-associated protein PV1 improves lung fibrosis | Marchetti GM, Burwell TJ, Peterson NC, Cann JA, Hanna RN, Li Q, Ongstad EL, Boyd JT, Kennedy MA, Zhao W, Rickert KW, Grimsby JS, DallAcqua WF, Wu H, Tsui P, Borrok MJ, Gupta R | 2019 | Communications Biology | Fibrosis | Area Quantification | HALO |
Persistence of inflammatory phenotype in residual psoriatic plaques in patients on effective biologic therapy: Residual Psoriatic Plaques After Treatment | Mashiko S, Edelmayer RM, Bi Y, Olson LM, Wetter JB, Wang J, Maari C, Proulx ES-C, Kaimal V, Li X, Salte K, Garcet S, Kannan AK, Huang SM, Cao X, Liu Z, Krueger JG, Sarfati M, Bissonnette R, Smith KM | 2019 | Journal of Investigative Dermatology | Immunology, Dermatology | Area Quantification | HALO |
In Situ Temporospatial Characterization of the Glial Response to Prion Infection | Michael AV, Greenlee JJ, Harm TA, Moore SJ, Zhang M, Lind MS, Greenlee MHW, Smith JD | 2019 | Veterinary Pathology | Immunology, Neuroscience, Infectious Disease | Area Quantification | HALO |
Exposure to maternal obesity programs sex differences in pancreatic islets of the offspring in mice | Nicholas LM, Nagao M, Kusinski LC, Fernandez-Twinn DS, Eliasson L, Ozanne SE | 2019 | Diabetologia | Metabolism | Area Quantification | HALO |
Histological characterization of aldosterone-producing adrenocortical adenomas with different somatic mutations | Ono Y, Yamazaki Y, Omata K, Else T, Tomlins SA, Rhayem Y, Williams TA, Reincke M, Carling T, Monticone S, Mulatero P, Beuschlein F, Ito S, Satoh F, Rainey WE, Sasano H | 2019 | The Journal of Clinical Endocrinology & Metabolism | Oncology | Classifier, Area Quantification | HALO |
Epithelial to mesenchymal plasticity and differential response to therapies in pancreatic ductal adenocarcinoma | Porter RL, Magnus NKC, Thapar V, Morris R, Szabolcs A, Neyaz A, Kulkarni AS, Tai E, Chougule A, Hillis A, Golczer G, Guo H, Yamada T, Kurokawa T, Yashaswini C, Ligorio M, Vo KD, Nieman L, Liss AS, Deshpande V, Lawrence MS, Maheswaran S, Fernandez-Del Castillo C, Hong TS, Ryan DP, ODwyer PJ, Drebin JA, Ferrone CR, Haber DA, Ting DT | 2019 | Proceedings of the National Academy of Sciences | Oncology | Area Quantification | HALO |
Multiplexed Immunohistochemistry for Molecular and Immune Profiling in Lung CancerÄîJust About Ready for Prime-Time? | Hofman P, Badoual C, Henderson F, Berland L, Hamila M, Long-Mira E, Lassalle S, Roussel H, Hofman V, Tartour E, Ilié M | 2019 | Cancers | Oncology, Immuno-oncology, Review | Classifier, Multiplex IHC | HALO |
Quantification of histopathological findings using a novel image analysis platform | Horai Y, Mizukawa M, Nishina H, Nishikawa S, Ono Y, Takemoto K, Baba N | 2019 | Journal of Toxicologic Pathology | Toxicology | Classifier | HALO |
Ex vivo tissue slice culture system to measure drug-response rates of hepatic metastatic colorectal cancer | Martin SZ, Wagner DC, Hörner N, Horst D, Lang H, Tagscherer KE, Roth W | 2019 | BMC Cancer | Oncology | Classifier, Cytonuclear | HALO |
Neutrophil content predicts lymphocyte depletion and anti-PD1 treatment failure in NSCLC | Kargl J, Zhu X, Zhang H, Yang GHY, Friesen TJ, Shipley M, Maeda DY, Zebala JA, McKay-Fleisch J, Meredith G, Mashadi-Hossein A, Baik C, Pierce RH, Redman MW, Thompson JC, Albelda SM, Bolouri H, Houghton AM | 2019 | JCI Insight | Immuno-oncology | Classifier, Highplex FL | HALO |
Precision immunoprofiling by image analysis and artificial intelligence | Koelzer VH, Sirinukunwattana K, Rittscher J, Mertz KD | 2019 | Vichows Archiv | Review | Classifier, Multiplex IHC, Spatial Analysis | HALO |
Machine learning approaches for pathologic diagnosis | Komura D, Ishikawa S | 2019 | Vichows Archiv | Review | Classifier | HALO AI |
MYB-NFIB gene fusions identified in archival adenoid cystic carcinoma tissue employing NanoString analysis: an exploratory study | McIntyre JB, Ko JJ, Siever J, Chan AMY, Simpson RHW, Hao D, Lau HY | 2019 | Diagnostic Pathology | Oncology | Classifier, Highplex FL | HALO |
A Dual Blocker of Endothelin A/B Receptors Mitigates Hypertension but not Renal Dysfunction in a Rat Model of Chronic Kidney Disease and Sleep Apnea | Morales-Loredo H, Jones DT, Barrera A, Mendiola P, Garcia J, Pace CE, Murphy M, Kanagy NL, Gonzalez Bosc LV | 2019 | Renal Pathology | Metabolism | Classifier, Cytonuclear, Figure Maker | HALO |
Detection of Lung Cancer Lymph Node Metastases from Whole-Slide Histopathologic Images Using a Two-Step Deep Learning Approach | Pham HHN, Futakuchi M, Bychkov A, Furukawa T, Kuroda K, Fukuoka J | 2019 | The American Journal of Pathology | Oncology | Classifier | HALO AI |
Imaging Mass Spectrometry and Proteome Analysis of Marek's Disease Virus-Induced Tumors | Pauker VI, Bertzbach LD, Hohmann A, Kheimar A, Teifke JP, Mettenleiter TC, Karger A, Kaufe BB | 2019 | mSpere | Oncology | Cytonuclear | HALO |
TNF-? Contributes to Lymphoid Tissue Disorganization and Germinal Center B Cell Suppression during Intracellular Bacterial Infection | Popescu M, Cabrera-Martinez B, Winslow GM | 2019 | The Journal of Immunology | Immunology | Cytonuclear | HALO |
Characterization of psoriasiform dermatitis induced by systemic injection of interleukin?23 minicircles in mice | Leys L, Wang Y, Paulsboe S, Edelmayer R, Salte K, Wetter J, Namovic M, Phillips L, Dunstan R, Gauvin D, Donnelly-Roberts D, Su Z, Honore P, McGaraughty S | 2019 | The Journal of Dermatology | Dermatology | Area Quantification, Layer Thickness | HALO |
Automated Computational Detection, Quantitation, and Mapping of Mitosis in WholeÄëSlide Images for Clinically Actionable Surgical Pathology Decision Support | Puri M, Hoover S, Hewitt S, Wei B-R, Adissu H, Halsey C, Beck J, Bradley C, Cramer S, Durham A, Esplin D, Frank C, Lyle L, McGill L, Sanchez M, Schaffer P, Traslavina R, Buza E, Yang H, Lee M, Dwyer J, Simpson R | 2019 | Journal of Pathology Informatics | Oncology | Cytonuclear | HALO |
Lamin?B1 is a senescence?associated biomarker in clear?cell renal cell carcinoma | Radspieler M, Schindeldecker M, Stenzel P, Försc S, Tagscherer K, Herpel E, Hohenfellner M, Hatiboglu G, Roth W, Macher?Goeppinger S | 2019 | Oncology Letters | Oncology | Cytonuclear | HALO |
Upper tract urothelial carcinoma has a luminal-papillary T-cell depleted contexture and activated FGFR3 signaling | Robinson BD, Vlachostergios PJ, Bhinder B, Liu W, Li K, Moss TJ, Bareja R, Park K, Tavassoli P, Cyrta J, Tagawa ST, Nanus DM, Beltran H, Molina AM, Khani F, Miguel Mosquera J, Xylinas E, Shariat SF, Scherr DS, Rubin MA, Lerner SP, Matin SF, Elemento O, Faltas BM | 2019 | Nature Communications | Oncology, Immuno-oncology | Cytonuclear | HALO |
IL?36 receptor antagonistic antibodies inhibit inflammatory responses in preclinical models of psoriasiform dermatitis | Su Z, Paulsboe S, Wetter J, Salte K, Kannan A, Mathew S, Horowitz A, Gerstein C, Namovic M, Todorovi? V, Seagal J, Edelmayer RM, Viner M, Rinaldi L, Zhou L, Leys L, Huang S, Wang L, Sadhukhan R, Honore P, McGaraughty S, Scott VE | 2019 | Experimental Dermatology | Dermatology | Area Quantification, Cytonuclear | HALO |
Neurexin 3 transmembrane and soluble isoform expression and splicing haplotype are associated with neuron inflammasome and Alzheimer's disease | Hishimoto A, Pletnikova O, Lang DL, Troncoso JC, Egan JM, Liu Q-R | 2019 | Alzheimer's Research & Therapy | Neuroscience | ISH/FISH | HALO |
IL?1? cleavage by inflammatory caspases of the noncanonical inflammasome controls the senescence?associated secretory phenotype | Wiggins KA, Parry AJ, Cassidy LD, Humphry M, Webster SJ, Goodall JC, Narita M, Clarke MCH | 2019 | Aging Cell | Immunology | Cytonuclear | HALO |
The role of WNT10B in normal prostate gland development and prostate cancer | Madueke I, Hu W-Y, Hu D, Swanson SM, Griend DV, Abern M, Prins GS | 2019 | The Prostate | Oncology | Multiplex IHC, TMA | HALO |
Role of IL-15 Signaling in the Pathogenesis of Simian Immunodeficiency Virus Infection in Rhesus Macaques | Okoye AA, DeGottardi MQ, FukazawaY, Vaidya M, Abana CO, Konfe AL, Fachko DN, Duell DM, He Li H, Lum R, Gao L, Park BS, Skalsky RL, Lewis AD, Axthelm MK, Lifson JD, Wong SW, Picker LJ | 2019 | The Journal of Immunology | Infectious Disease | Cytonuclear, Figure Maker | HALO |
A Deep Learning Convolutional Neural Network Can Recognize Common Patterns of Injury in Gastric Pathology | Martin DR, Hanson JA, Gullapalli RR, Schultz FA, Sethi A, Clark DP | 2019 | Archives of Pathology and Laboratory Medicine | Gastroenterology | HALO AI | |
Advanced Prostate Cancer with ATM Loss: PARP and ATR Inhibitors | Neeb A, Herranz N, Arce-Gallego S, Miranda S, Lorenzo Buroni L, Wei Yuan W, Alejandro Athie A, Teresa Casals T, Juliet Carmichael J, Daniel Nava Rodrigues DN, Bora Gurel B, Pasquale Rescigno P, Jan Rekowski J, Jon Welti J, Ruth Riisnaes R, Veronica Gil V, Jian Ning J, Verena Wagner, Irene Casanova-Salas I, Cordoba S, Natalia Castro N, Maria Dolores Fenor de la Maza, George Seed, Khobe Chandran, Ana Ferreira A, Ines Figueiredo I, Claudia Bertan, Diletta Bianchini, Caterina Aversa, Alec Paschalis A, Macarena Gonzalez N, Rafael Morales-Barrera, Cristina Suarez C, Joan Carles J, Amanda Swain A, Adam Sharp A, Jesus Gil, Violeta Serra, Christopher Lord, Suzanne Carreira S, Joaquin Mateo, Johann S. de Bono JS | 2019 | European Urology | Oncology | HALO AI | |
Reduction of Global H3K27me3 Enhances HER2/ErbB2 Targeted Therapy | Hirukawa A, Singh S, Wang J, Rennhack JP, Swiatnicki M, Sanguin-Gendreau V, Zuo D, Daldoul K, Lavoie C, Park M, Andrechek ER, Westbrook TF, Harris LN, Varadan V, Smith HW, Muller WJ | 2019 | Cell Reports | Oncology | Highplex FL | HALO |
Macrophage-Derived CXCL9 and CXCL10 Are Required for Antitumor Immune Responses Following Immune Checkpoint Blockade | House IG, Savas P, Lai J, Chen AXY, Oliver AJ, Teo ZL, Todd KL, Henderson MA, Giuffrida L, Petley EV, Sek K, Mardiana S, Gide TN, Quek C, Scolyer RA, Long GV, Wilmott JS, Loi S, Darcy PK, Beavis PA | 2019 | Clinical Cancer Research | Immuno-oncology | Highplex FL | HALO |
A single dose of neoadjuvant PD-1 blockade predicts clinical outcomes in resectable melanoma | Huang AC, Orlowski RJ, Xu X, Mick R, George SM, Yan PK, Manne S, Kraya AA, Wubbenhorst B, Dorfman L, DAndrea K, Wenz BM, Liu S, Chilukuri L, Kozlov A, Carberry M, Giles L, Kier MW, Quagliarello F, McGettigan S, Kreider K, Annamalai L, Zhao Q, Mogg R, Xu W, Blumenschein WM, Yearley JH, Linette GP, Amaravadi RK, Schuchter LM, Herati RS, Bengsch B, Nathanson KL, Farwell MD, Karakousis GC, Wherry EJ, Mitchell TC | 2019 | Nature Medicine | Oncology, Immuno-oncology | Highplex FL | HALO |
CXCR3 enables recruitment and site-specific bystander activation of memory CD8+ T cells | Maurice NJ, McElrath MJ, Andersen-Nissen E, Frahm N, Prlic M | 2019 | Nature Communications | Immunology | Highplex FL | HALO |
Development of resistance to FAK inhibition in pancreatic cancer is linked to stromal depletion | Jiang H, Liu X, Knolhoff BL, Hegde S, Lee KB, Jiang H, Fields RC, Pachter JA, Lim K-H, DeNardo DG | 2019 | Gut | Oncology | Cytonuclear, ISH/FISH | HALO |
Single-Cell Quantification of mRNA Expression in The Human Brain | Jolly S, Lang V, Koelzer VH, Frigerio CS, Magno L, Salinas PC, Whiting P, Palomer E | 2019 | Scientific Reports | Neuroscience | ISH/FISH | HALO |
The Fat Mass and Obesity-Associated Protein (FTO) Regulates Locomotor Responses to Novelty via D2R Medium Spiny Neurons | Ruud J, Alber J, Tokarska A, Engström Ruu L, Nolte H, Biglari N, Lippert R, Lautenschlager Ä, Cie?lak PE, Szumiec ?, Hess ME, Brönneke HS, Krüger M, Nissbrandt H, Korotkova T, Silberberg G, Rodriguez Parkitna J, Brüning J | 2019 | Cell Reports | Neuroscience, Metabolism | ISH/FISH | HALO |
Quantitative digital pathology reveals association of cell-specific PNPLA3 transcription with NAFLD disease activity | Sandhu B, Perez Matos MC, Tran S, Zhong A, Csizmadia E, Kim M, Herman MA, Nasser I, Lai M, Jiang ZG | 2019 | JHEP Reports | Fibrosis | ISH/FISH | HALO |
Alpha-synuclein is a DNA binding protein that modulates DNA repair with implications for Lewy body disorders | Schaser AJ, Osterberg VR, Dent SE, Stackhouse TL, Wakeham CM, Boutros SW, Weston LJ, Owen N, Weissman TA, Luna E, Raber J, Luk KC, McCullough AK, Woltjer RL, Unni VK | 2019 | Scientific Reports | Neuroscience | ISH/FISH | HALO |
Small Molecule IL-36? Antagonist as a Novel Therapeutic Approach for Plaque Psoriasis | Todorovi? V, Su Z, Putman CB, Kakavas SJ, Salte KM, McDonald HA, Wetter JB, Paulsboe SE, Sun Q, Gerstein CE, Medina L, Sielaff B, Sadhukhan R, Stockmann H, Richardson PL, Qiu W, Argiriadi MA, Henry RF, Herold JM, Shotwell JB, McGaraughty SP, Honore P, Gopalakrishnan SM, Sun CC, Scott VE | 2019 | Scientific Reports | Immunology, Dermatology | ISH/FISH | HALO |
Changes in epidermal morphology associated with dandruff | Pople JE, Bhogal RK, Moore AE, Jenkins G | 2019 | International Journal of Cosmetic Science | Dermatology | Cytonuclear, Layer Thickness | HALO |
PD-L1 Expression and Clinical Outcomes to Cabozantinib, Everolimus, and Sunitinib in Patients with Metastatic Renal Cell Carcinoma: Analysis of the Randomized Clinical Trials METEOR and CABOSUN | Flaifel A, Xie W, Braun DA, Ficial M, Bakouny Z, Nassar AH, Jennings RB, Escudier B, George DJ, Motzer RJ, Morris MJ, Powles, Wang E, Huang Y, Freeman GJ, Choueiri TK, Signoretti S | 2019 | Clinical Cancer Research | Immuno-oncology | Multiplex IHC | HALO |
The KDM5A/RBP2 histone demethylase represses NOTCH signaling to sustain neuroendocrine differentiation and promote small cell lung cancer tumorigenesis | Oser MG, Sabet AH, Gao W, Chakraborty AA, Schinzel AC, Jennings RB, Fonseca R, Bonal DM, Booker MA, Flaifel A, Novak JS, Christensen VL, Zhang H, Herbert ZT, Tolstorukov MY, Buss EJ, Wong K-K, Bronson RT, Nguyen Q-D, Signoretti S, Kaelin Jr WG | 2019 | Genes & Development | Oncology | Multiplex IHC | HALO |
Physiologic serum 1,25 dihydroxyvitamin D is inversely associated with prostatic Ki67 staining in a diverse sample of radical prostatectomy patients | Rosenberg A, NetteY OS, Gogana P, Sheikh U, Virgilia M, Macias V, Kajdacsy-Balla A, R Sharifi R, Kittles RA, Murphy AB | 2019 | Cancer Causes & Control | Oncology | Multiplex IHC | HALO |
Nuclear Glycogenolysis Modulates Histone Acetylation in Human Non-Small Cell Lung Cancers | Sun RC, Dukhande VV, Zhou Z, Young LEA, Emanuelle S, Brainson CF, Gentry MS | 2019 | Cell Metabolism | Oncology | Multiplex IHC | HALO |
Inducing and exploiting vulnerabilities for the treatment of liver cancer | Wang C, Vegna S, Jin H, Benedict B, Lieftink C, Ramirez C, de Oliveira RL, Morris B, Gadiot J, Wang W, du Chatinier A, Wang L, Gao D, Evers B, Jin G, Xue Z, Schepers A, Jochems F, Sanchez AM, Mainardi S, te Riele H, Beijersbergen RL, Qin W, Akkari L, Bernards R | 2019 | Nature | Oncology | Multiplex IHC | HALO |
Neoadjuvant anti-PD-1 immunotherapy promotes a survival benefit with intratumoral and systemic immune responses in recurrent glioblastoma | Cloughesy TF, Mochizuki AY, Orpilla JR, Hugo W, Lee AH, Davidson TB, Wang AC, Ellingson BM, Rytlewski JA, Sanders CM, Kawaguchi ES, Du L, Li G, Yong WH, Gaffey SC, Cohen AL, Mellinghoff IK, Lee EQ, Reardon DA, OBrien BJ, Butowski NA, Nghiemphu PL, Clarke JL, Arrillaga-Romany IC, Colman H, Kaley TJ, de Groot JF, Liau LM, Wen PY, Prins RM | 2019 | Nature Medicine | Oncology, Immuno-oncology | Spatial Analysis, Highplex FL | HALO |
PAK4 inhibition improves PD-1 blockade immunotherapy | Abril-Rodriguez G, Torrejon DY, Liu W, Zaretsky JM, Nowick TS, Tsoi J, Puig-Saus C, Baselga-Carretero I, Medina E, Quist MJ, Garcia AJ, Senapedis W, Baloglu E, Kalbasi A, Cheung-Lau G, Berent-Maoz B, Comin-Anduix B, Hu-Lieskovan S, Wang C-Y, Grasso CS, Ribas A | 2019 | Nature Cancer | Immuno-oncology | HALO | |
Histological characterization of aldosterone-producing adrenocortical adenomas with different somatic mutations | Acosta-Ruiz A, Gutzeit VA, Skelly MJ, Meadows S, Lee J, Parekh P, Orr AG, Liston C, Pleil KE, Broichhagan J, Levitz J | 2019 | Neuron | Neuroscience | HALO | |
Amyloid-Beta (A?) Plaques Promote Seeding and Spreading of Alpha-Synuclein and Tau in a Mouse Model of Lewy Body Disorders with A? Pathology | Bassil F, Brown HJ, Pattabhiraman S, Iwasyk JE, Maghames CM, Meymand ES, Cox TO, Riddle FM, BinZhang N, Trojanowski JQ, Lee VM-Y | 2019 | Neuron | Neuroscience | HALO | |
Rabbit monoclonal E?cadherin antibody: A cost?effective alternative to mouse monoclonal antibody in distinguishing ductal carcinoma in situ from lobular carcinoma in situ | Baum JE, Croyle JA, Brodsky VB, Liu Y, Shin SJ | 2019 | The Breast Journal | Oncology | Cytonuclear | HALO |
MAPKAPK2 (MK2) inhibition mediates radiation-induced inflammatory cytokine production and tumor growth in head and neck squamous cell carcinoma | Berggren KL, Cruz SR, Hixon MD, Cowan AT, Keysar SB, Craig S, James J, Barry M, Ozbun MA, Jimeno A, McCance DJ, Beswick EJ, Gan GN | 2019 | Oncogene | Oncology | Cytonuclear, Figure Maker | HALO |
Pre-diagnostic anthropometry, sex, and risk of colorectal cancer according to tumor immune cell composition | Berntsson J, Eberhard J, Nodin B, Leandersson K, Larsson AH, Eberhard J, Jirstrom K | 2019 | OncoImmunology | Immuno-oncology | HALO | |
Single cell transcriptomic profiling of large intestinal enteroendocrine cells in mice - Identification of selective stimuli for insulin-like peptide-5 and glucagon-like peptide-1 co-expressing cells | Billing LJ, Larraufie P, Lewis J, Leiter A, Li J, Lam B, Yeo GSH, Goldspink DA, Kay RG, Gribble FM, Reimann F | 2019 | Molecular Metabolism | Metabolism | HALO | |
Genetic mutations underlying phenotypic plasticity in basosquamous carcinoma | Chiang A, Tan CZ, Kuonen F, Hodgkinson LM, Chiang F, Cho RJ, South AP, Tang Jean Y, Chang ALS, Rieger KE, Oro AE, Sarin KY | 2019 | Journal of Investigative Dermatology | Oncology | Cytonuclear | HALO |
Kras and Lkb1 mutations synergistically induce intraductal papillary mucinous neoplasm derived from pancreatic duct cells | Collet L, Ghurburrun E, Meyers N, Assi M, Pirlot B, Leclercq IA, Couvelard A, Komuta M, Cros J, Demetter P, Lemaigre FP, Borbath I, Jacquemin P | 2019 | Gut | Oncology | HALO | |
Next-generation computational tools for interrogating cancer immunity | Finotello F, Rieder D, Hackl H, Trajanoski Z | 2019 | Nature Reviews Genetics | Review | HALO | |
The crosstalk between aldosterone and calcium metabolism in primary aldosteronism: A possible calcium metabolism-associated aberrant neoplastic steroidogenesis in adrenals | Gao X, Yamazaki Y, Tezuka Y, Onodera Y, Ogata H, Omata K, Morimoto R, Nakamura Y, Satoh F, Sasano H | 2019 | The Journal of Steroid Biochemistry and Molecular Biology | Oncology, Metabolism | Cytonuclear | HALO |
Farnesoid X Receptor Agonism, AcetylCoenzyme A Carboxylase Inhibition, and Back Translation of Clinically Observed Endpoints of De Novo Lipogenesis in a Murine NASH Model | Gapp B, Jourdain M, Bringer P, Kueng B, Weber D, Osmont A, Zurbruegg S, Knehr J, Falchetto R, Roma G, Dietrich W, Valdez R, Beckmann N, Nigsch F, Sanyal AJ, Ksiazek I | 2019 | Hepatology Communications | Metabolism | Cytonuclear | HALO |
Open radial artery harvesting better preserves endothelial function compared to the endoscopic approach | Gaudino MF, Lorusso R, Ohmes LB, Narula N, McIntire PJ, Gargiulo A, Bucci MR, Leonard J, Rahouma M, Di Franco A, He GW, Girardi LN, Tranbaugh RF, Di Lorenzo A | 2019 | Interactive CardioVascular and Thoracic Surgery | HALO | ||
Dynamic changes to lipid mediators support transitions among macrophage subtypes during muscle regeneration | Giannakis N, Sansbury BE, Patsalos A, Hays TT, Riley CO, Han X, Spite M, Nagy L | 2019 | Nature Immunology | Immunology, Myology | Muscle Fiber | HALO |
Evaluation of Peritumoral Fibrosis in Metastatic Colorectal Adenocarcinoma to the Liver Using Digital Image Analysis | Waters KM, Cottrell TR, Besharati S, Zhu Q, Anders RA | 2019 | American Journal of Clinical Pathology | Oncology | Area Quantification, Partitions (tiles, margins) | HALO |
Cross-Platform Comparison of Computer-assisted Image Analysis Quantification of In Situ mRNA Hybridization in Investigative Pathology. | Holzer TR, Hanson JC, Wray EM, Bailey JA, Kennedy KR, Finnegan PR, Nasir A, Credille KM | 2019 | Applied Immunohistochemistry & Molecular Morpholgy | HALO | ||
Oral tenofovir disoproxil fumarate/emtricitabine for HIV pre-exposure prophylaxis increases expression of type I/III interferon-stimulated factors in the gastrointestinal tract but not in the blood | Hughes SM, Levy CN, Calienes F, Stekler JD, Pandey U, Vojtech L, Berard AR, Birse K, Noel-Romas L, Richardson B, Golden J, Cartwright M, Collier AC, Stevens CE, Curlin ME, Holtz TH, Mugo N, Irungu E, Katabira E, Muwonge T, Lama JR, Baeten JM, Burgener A, Lingappa JR, McElrath MJ, Mackelprang R, McGowan I, Cranston RD, Cameron MJ, Hladik F | 2019 | bioRxiv | Infectious Disease | Cytonuclear | HALO |
Intraintestinal and Parenteral Administration of an Insulin Analogue Leads to Comparable Activation of Signaling Downstream of the Insulin Receptor in the Small Intestine | Hvid H, Kildegaard J, Kristensen K, Porsgaard T, Jørgensen MS, Ballarín-González B, Ahnfelt-Rønne J, Hansen Bo F, Nishimura E | 2019 | Journal of Diabetes Science and Technology | Metabolism | HALO | |
Epithelial NOTCH Signaling Rewires the Tumor Microenvironment of Colorectal Cancer to Drive Poor-Prognosis Subtypes and Metastasis | Jackstadt R, van Hooff ST, Leach JD, Cortes-Lavaud X, Lohuis JO, Ridgway RA, Wouters VM, JatinRoper J, Kendall TJ, Roxburgh CS, Horgan PG, Nixon C, Nourse C, Gunzer M, Clark W, Hedley A, Yilmaz OH, Rashid M, Bailey P, Biankin AV, Campbell AD, Adams DJ, Barry ST, Steele CW, Medema JP, Sansom OJ | 2019 | Cancer Cell | Oncology | HALO | |
Expression of avian ?-defensin mRNA in the chicken yolk sac | Zhang H, Wong EA | 2019 | Developmental & Comparative Immunology | Immunology | ISH/FISH | HALO |
Lenvatinib plus anti-PD-1 antibody combination treatment activates CD8+ T cells through reduction of tumor-associated macrophage and activation of the interferon pathway | Kato Y, Tabata K, Kimura T, Yachie-Kinoshita A, Ozawa Y, Yamada K, Ito J, Tachino S, Hori Y, Matsuki M, Matsuoka Y, Ghosh S, Kitano H, Nomoto K, Matsui J, Funahashi Y | 2019 | PLOS One | Immuno-oncology | HALO | |
Calpain 9 as a therapeutic target in TGF?-induced mesenchymal transition and fibrosis | Kim DH, Beckett JD, Nagpal V, Seman-Senderos MA, Gould Russell A, Creamer TJ, MacFarlane EG, Chen Y, Bedja D, Butcher JT, Mitzner W, Rouf R, Hata S, Warren DS, Dietz HC | 2019 | Science Translational Medicine | Fibrosis | HALO | |
Delayed Azithromycin Treatment Improves Recovery After Mouse Spinal Cord Injury | Kopper TJ, McFarlane KE, Bailey WM, Orr MB, Zhang B, Gensel JC | 2019 | Frontiers in Ceullar Neuroscience | Neuroscience | HALO | |
Long-Term Persistence of Anti-HIV Broadly Neutralizing Antibody-Secreting Hematopoietic Cells in Humanized Mice | Kuhlmann A-S, Haworth KG, Barber-Axthelm IM, Ironside C, Giese MA, Peterson CW, Kiem H-P | 2019 | Molecular Therapy | Infectious Disease | HALO | |
Temporal Analysis of Amylase Expression in Control, Autoantibody Positive, and Type 1 Diabetes Pancreatic Tissues | Kusmartseva I, Beery M, Hiller H, Padilla M, Selman S, Posgai A, Nick HS, Campbell-Thompson M, Schatz DA, Haller MJ, Wasserfall CH, Atkinson MA | 2019 | Diabetes | Metabolism | HALO | |
Phosphorylation of connexin 43 at MAPK, PKC or CK1 sites each distinctly alter the kinetics of epidermal wound repair | Lastwika JK, Dunn CA, Solan JL, Lampe PD | 2019 | Journal of Cell Science | HALO | ||
Active Cushing's Disease is Characterized by Increased Adipose Tissue Macrophage Presence | Lee IT, Atuahene A, Egritag HE, Buettner C, Wang L, Geer EB, Donovan M | 2019 | The Journal of Clinical Endocrinology & Metabolism | Metabolism | HALO | |
Impact of a Pre-Operative Exercise Intervention on Breast Cancer Proliferation and Gene Expression: Results from the Pre-Operative Health and Body (PreHAB) Study | Ligibel JA, Dillon D, Giobbie-Hurder A, McTiernan A, Frank E, Cornwell M, Pun M, Campbell N, Dowling RJO, Chang MC, Tolaney S, Chagpar AB, Yung RL, Freedman RA, Dominici LS, Golshan M, Rhei E, Taneja K, Huang Y, Brown M, Winer EP, Jeselsohn R, Irwin ML | 2019 | Clinical Cancer Research | HALO | ||
A phase 2 study of GVAX colon vaccine with cyclophosphamide and pembrolizumab in patients with mismatch repair proficient advanced colorectal cancer | Yarchoan M, Huang C-Y, Zhu Q, Ferguson AK, Durham JN, Anders RA, Thompson ED, Rozich NS, Thomas DL, Nauroth JM, Rodriguez C, Osipov A, De Jesus-Acosta A, Le DT, Murphy AG, Laheru D, Donehower RC, Jaffee EM, Zheng L, Azad NS | 2019 | Cancer Medicine | Immuno-oncology | Area Quantification, Partitions (tiles, margins) | HALO |
Hotspot enumeration of CD8+ tumor infiltrating lymphocyte using digital image analysis in triple negative breast Cancer yields consistent results | McIntire PJ, Zhong E, Patel A, Khani F, D'Alfonso T, Chen Z, Shin SJ, Ginter PS | 2019 | Human Pathology | Oncology | Cytonuclear | HALO |
Female-biased embryonic death from inflammation induced by genomic instability | McNairn AJ, Chuang C-H, Bloom JC, Wallace MD, Schimenti JC | 2019 | Nature | Immunology | Cytonuclear | HALO |
Imaging CAR T cell therapy with PSMA-targeted positron emission tomography | Minn I, Huss DJ, Ahn H-H, Chinn TM, Park A, Jones J, Brummet M, Rowe SP, Sysa-Shah P, Du Y, Levitsky HI, Pomper MG | 2019 | Science Advances | Oncology | Cytonuclear | HALO |
Reliable identification of prostate cancer using mass spectrometry metabolomic imaging in needle core biopsies | Morse N, Jamaspishvili T, Simon D, Patel PG, Ren KYM, Wang J, Oleschuk R, Kaufmann M, Gooding RJ, Berman DM | 2019 | Laboratory Invesigations | Oncology | HALO | |
Efficacy of ruthenium coordination complex-based Rutherrin in a preclinical rat glioblastoma model | Munegowda MA, Fisher C, Molehuis D, Foltz W, Roufaiel M, Bassan J, Nitz M, Mandel A, Lilge L | 2019 | Neuro-Oncology Advances | HALO | ||
HIF-independent synthetic lethality between CDK4/6 inhibition and VHL loss across species | Nicholson HE, Tariq Z, Housden BE, Jennings RB, Stransky LA, Perrimon N, Signoretti S, Kaelin WG | 2019 | Cancer Therapy | HALO | ||
Prohibitin is a prognostic marker of relapse and therapeutic target to block chemotherapy resistance in Wilms tumor | Ortiz MV, Ahmed S, Burns M, Henssen AG, Hollmann TJ, MacArthur I, Gunasekera S, Gaewsky L, Bradwin G, Ryan J, Letai A, He Y, Naranjo A, Chi Y-Y, LaQuaglia M, Heaton T, Cifani P, Dome JS, Gadd S, Perlman E, Mullen E, Steen H, Kentsis A | 2019 | JCI Insight | Oncology | Cytonuclear | HALO |
Validation and characterisation of prognostically significant PD-L1+ immune cells in HPV+ oropharyngeal squamous cell carcinoma | Young RJ, Bressel M, Porceddu S, Cernelc J, Savas P, Liu H, Urban D, Thai AA, Cooper C, Fua T, Neeson P, Rischin D, Solomon B | 2019 | Oral Oncology | Oncology, Infectious Disease | Classifier, Highplex FL | HALO |
Human 3D Gastrointestinal Microtissue Barrier Function As a Predictor of Drug-Induced Diarrhea | Peters MF, Landry T, Pin C, Maratea K, Dick C, Wagoner MP, Choy AL, Barthlow H, Snow D, Stevens Z, Armento A, Scott CW, Ayehunie S | 2019 | Toxicological Sciences | Gastroenterology | HALO | |
PTEN loss in Gleason grade 7 prostate tumors exhibits intratumoral heterogeneity and is associated with unfavorable pathological features | Picanço-Albuquerque CG, Vidotto T, Pereira CS, Saggioro FP, Jamaspishvili T, Koti M, Berman DM, Squire JA, Reis RB | 2019 | Applied Cancer Research | Oncology | HALO | |
Extramammary Paget disease shows differential expression of B7 family members B7-H3, B7-H4, PD-L1, PD-L2 and cancer/testis antigens NY-ESO-1 and MAGE-A | Pourmaleki M, Young JH, Socci ND, Chiang S, Edelweiss M, Li Y, Zhang M, Roshal L, Chi DS, Busam KJ, Mellinghoff IK, Hollmann TJ | 2019 | Oncotarget | HALO | ||
Impact of TREM2 risk variants on brain region-specific immune activation and plaque microenvironment in Alzheimer's disease patient brain samples | Prokop S, Miller KR, Labra SR, Pitkin RM, Hoxha K, Narasimhan S, Changolkar L, Rosenbloom A, Lee VM-Y, Trojanowski JQ | 2019 | Acta Neuropathologica | Neuroscience | HALO | |
Delta-like protein 3 expression and therapeutic targeting in neuroendocrine prostate cancer | Puca L, Gavyert K, Sailer V, Conteduca V, Dardenne E, Sigouros M, Isse K, Kearney M, Vosoughi A, Fernandez L, Pan H, Motanagh S, Hess J, Donoghue AJ, Sboner A, Wang Y, Dittamore R, Rickman D, Nanus DM, Tagawa ST, Elemento O, Mosquera JM, Saunders L, Beltran H | 2019 | Science Translational Medicine | Oncology | HALO | |
Mitogenic and progenitor gene programmes in single pilocytic astrocytoma cells | Reitman ZJ, Paolella BR, Bergthold G, Pelton K, Becker S, Jones R, Sinai CE, Malkin H, Huang Y, Grimmet L, Herbert ZT, Sun Y, Weatherbee JL, Alberta JA, Daley JF, Rozenblatt-Rosen O, Condurat AL, Qian K, Khadka P, Segal RA, Haas-Kogan D, Filbin MG, Suva ML, Regev A, Stiles CD, Kieran MW, Goumnerova L, Ligon KL, Shalek AK, Bandopadhayay P, Beroukhim R | 2019 | Nature Communications | Oncology | HALO | |
Pre-exposure prophylaxis differentially alters circulating and mucosal immune cell activation in herpes simplex virus type 2 seropositive women | Richert-Spuhler LE, Pattacini L, Plews M, Irungu E, Muwonge TR, Katabira E, Mugo N, Meyers AFA, Celum C, Baeten JM, Lingappa JR, Lund JM | 2019 | AIDS | Infectious Disease | HALO | |
A MYCGCN2eIF2? negative feedback loop limits protein synthesis to prevent MYC-dependent apoptosis in colorectal cancer | Schmidt S, Gay D, Uthe FW, Denk S, Paauwe M, Matthes N, Diefenbacher ME, Bryson S, Warrander FC, Erhard F, Ade CP, Baluapuri A, Walz S, Jackstadt R, Ford C, Vlachogiannis G, Valeri N, Otto C, Schülein-Völk C, Maurus K, Schmitz W, Knight JRP, Wolf E, Strathdee D, Schulze A, Germer C-T, Rosenwald A, Sansom OJ, Eilers M | 2019 | Nature Cell Biology | Oncology | HALO | |
Mobilization of CD8+ T cells via CXCR4 blockade facilitates PD-1 checkpoint therapy in human pancreatic cancer | Seo YD, Jiang X, Sullivan KM, Jalikis FG, Smythe KS, Abbasi A, Vignali M, Park JO, Daniel SK, Pollack SM, Kim TS, Yeung R, Crispe IN, Pierce RH, Robins H, Pillarisetty VG | 2019 | Clinical Cancer Research | Immuno-oncology | HALO | |
Targeting glutamate metabolism in melanoma | Singh S, Shah R, Chen S, Filipp FV | 2019 | arXiv | HALO | ||
Logic-Gated ROR1 Chimeric Antigen Receptor Expression Rescues T Cell-Mediated Toxicity to Normal Tissues and Enables Selective Tumor Targeting | Srivastava S, Salter A, Liggitt D, Yechan-Gunja S, Sarvothama M, Cooper K, Smythe KS, Dudakov JA, Pierce RH, Rader C, Riddell SR | 2019 | Cancer Cell | Oncology, Immuno-oncology | HALO | |
Citrullination of fibronectin alters integrin clustering and focal adhesion stability promoting stromal cell invasion | Stefanelli VL, Choudhury S, Hu P, Liu Y, Schwenzer A, Yeh C-R, Chambers DM, Pesson K, Li W, Segura T, Midwood KS, Torres M, Barker TH | 2019 | Matrix Biology | Oncology, Fibrosis | HALO | |
A Short Isoform of Coagulation Factor XII mRNA Is Expressed by Neurons in the Human Brainl | Zamolodchikov D, Bai Y, Tang Y, McWhirter JR, Macdonald LE, Alessandri-Haber N | 2019 | Neuroscience | Neuroscience | Figure Maker | HALO |
Automated macrophage counting in DLBCL tissue samples: a ROF filter based approach | Wagner M, Hansel R, Reinke S, Richter J, Altenbuchinger M, Braumann U-D, Spang R, Loffler Mk Klapper W | 2019 | Biological Proectures Online | Oncology | Object Colocalization | HALO |
Impact of pre?therapy glioblastoma multiforme microenvironment on clinical response to autologous CMV?specific T?cell therapy | Walker DG, Shakya R, Morrison B, Neller MA, Matthews KK, Nicholls J, Smith C, Khanna R | 2019 | Clinical & Translational Immunology | Immuno-oncology | Classifier | HALO |
Human pseudoislet system enables detection of differences in G-protein-coupledreceptor signaling pathways between ? and ? cells | Walker JT, Haliyur R, Nelson HA, Ishahak M, Poffenberger G, Aramandla R, Reihsmann C, Luchsinger JR, Saunders DC, Wang P, Garcia-Ocana A, Bottino R, Agarwal A, Powers AC, Brissove M | 2019 | bioRxiv | HALO | ||
Multiplex Immunofluorescence of Bone Marrow Core Biopsies: Visualizing the Bone Marrow Immune Contexture | Walters DK, Jelinek DF | 2019 | Journal of Histochemistry & Cytochemistry | HALO | ||
No Evidence of Neurogenesis in Adult Rat Sympathetic Ganglia Following Guanethidine-Induced Neuronal Loss | Walters KM, Boucher M, Boucher GG, Opsahl AC, Mouton PR, Liu C-N, Ritenour CR, Kawabe TT, Pryski HN, Somps CJ | 2019 | Toxicologic Pathology | Toxicology, Neuroscience | HALO | |
ATDC is required for the initiation of KRAS-induced pancreatic tumorigenesis | Wang L, Yang H, Zamperone A, Diolaiti D, Palmbos PL, Abel EV, Purohit V, Dolgalev I, Rhim AD, Ljungman M, Hadju CH, Halbrook CJ, Bar-Sagi D, di Magliano MP, Crawford HC, Simeone DM | 2019 | Genes & Development | Oncology | HALO | |
Monocytes/Macrophages play a pathogenic role in IL-23 mediated psoriasis-like skin inflammation | Wang Y, Edelmayer R, Wetter J, Salte K, Gauvin D, Leys L, Paulsboe S, Su Z, Weinberg I, Namovic M, Gauld SB, Honore P, Scott VE, McGaraughty S | 2019 | Scientific Reports | Immunology, Dermatology | HALO | |
Myeloid Cell-Derived HB-EGF Drives Tissue Recovery After Pancreatitis | Wen H-J, Gao S, Wang Y, Ray M, Magnuson MA, Wright CVE, Di Magliano MP, Frankel TL, Crawford HC | 2019 | Cellular and Molecular Gastroenterology and Hepatology | Immunology | HALO | |
Nrf2 represses the onset of type 1 diabetes in non-obese diabetic mice | Yagishita Y, Uruno A, Chartoumpekis DV, Kensler TW, Yamamoto M | 2019 | The Journal of Endocrinology | Metabolism | HALO | |
Systemic mRNA Therapy for the Treatment of Fabry Disease: Preclinical Studies in Wild-Type Mice, Fabry Mouse Model, and Wild-Type Non-human Primates | Zhu S, Li S, Escuin-Ordinas H, Dimatteo R, Xia W, Ribas A, Segura T | 2019 | The American Journal of Human Genetics | Metabolism | HALO | |
Selective modulation of the androgen receptor AF2 domain rescues degeneration in spinal bulbar muscular atrophy | Badders NM, Korff A, Miranda HC, Vuppala PK, Smith RB, Winborn BJ, Quemin ER, Sopher BL, Dearman J, Messing J, Kim NC, Moore J, Freibaum BD, Kanagaraj AP, Fan B, Tillman H, Chen P-C, Wang Y, Freeman BB, Li Y, Kim HJ, La Spada AR, Taylor JP | 2018 | Nature Medicine | Myology | Area Quantification | HALO |
Anti-NKG2A mAb Is a Checkpoint Inhibitor that Promotes Anti-tumor Immunity by Unleashing Both T and NK Cells | Andre ?P, Denis C, Soulas C, Bourbon-Caillet C, Lopez J, Arnoux T, Ble?ry M, Bonnafous C, Gauthier L, Morel A, Rossi B, Remark R, Breso V, Bonnet E, Habif G, Guia S, Lalanne AI, Hoffmann C, Lantz O, Fayette J, Boyer-Chammard A, Zerbib R, Dodion P, Ghadially H, Jure-Kunkel M, Morel Y, Herbst R, Narni-Mancinelli E, Cohen RB, Vivier E | 2018 | Cell | Oncology, Immuno-oncology | Area Quantification, Cytonuclear | HALO |
Tuning of delta-protocadherin adhesion through combinatorial | Bisogni AJ, Ghazanfar S, Williams EO, Marsh HM, Yang JYH, Lin DM | 2018 | eLife | Neuroscience | Area Quantification | HALO |
RAD51 foci as a functional biomarker of homologous recombination repair and PARP inhibitor resistance in germline BRCA mutated breast cancer | Cruz C, Castroviejo-Bermejo M, Gutiérrez-Enríquez S, Llop-Guevara A, Ibrahim YH, Gris-Oliver A, Bonache S, Morancho B, Bruna A, Rueda OM, Lai Z, Polanska UM, Jones GN,Kristel P, de Bustos L, Guzman M, Rodriguez O, Grueso J, Montalban G, Caratú G, Mancuso F, Fasani R, Jiménez J, Howat WJ, Dougherty B, Vivancos A, Nuciforo P, Serres-Créixams X, Rubio IT, Oaknin A, Cadogan O, Barrett JC, Caldas C, Baselga J, Saura C, Cortés J, Arribas J, Jonkers J, Díez O, OConnor MJ, Balmaña J, SerraV | 2018 | Annals of Oncology | Oncology | Classifier, Cytonuclear | HALO |
The brain-penetrant clinical ATM inhibitor AZD1390 radiosensitizes and improves survival of preclinical brain tumor models | Durant ST, Zheng L, Wang Y, Chen K, Zhang L, Zhang T, Yang Z, Riches L, Trinidad AG, Fok JHL, Hunt T, Pike KG, Wilson J, Smith A, Colclough N, Reddy VP, Sykes A, Janefeldt A, Johnström P, Varnäs K, Takano A, Ling S, Orme J, Stott J, Roberts C, Barrett I, Jones G, Roudier M, Pierce A, Allen J, Kahn J, Sule A, Karlin J, Cronin A, Chapman M, Valerie K, Illingworth R, Pass M | 2018 | Science Advances | Oncology, Neuroscience | Classifier, Cytonuclear | HALO |
High response rate to PD-1 blockade in desmoplastic melanomas | Eroglu Z, Zaretsky JM, Hu-Lieskovan H, Kim DW, Algazi A, Johnson DB, Liniker E, Kong B, Munhoz R, Rapisuwon S, Gherardini PF, Chmielowski B, Wang X, Shintaku IP, Wei C, Sosman JA, Joseph RW, Postow MA, Carlino MS, Hwu W-J, Scolyer RA, Messina J, Cochran AJ, Long GV, Ribas A | 2018 | Nature | Oncology, Immuno-oncology | Cytonuclear | HALO |
Early Stage HER2-Positive Breast Cancers Not Achieving a pCR From Neoadjuvant Trastuzumab- or Pertuzumab-Based Regimens Have an Immunosuppressive Phenotype | Force J, Howie LJ, Abbot SE, Bentley R, Marcom PK, Kimmick G, Westbrook K, Sammons SL, Parks M, Topping DL, Emerson R, Broadwater G, Hyslop T, Blackwell KL, Nair SK | 2018 | Clinical Breast Cancer | Oncology, Immuno-oncology | Cytonuclear | HALO |
Bortezomib prevents cytarabine resistance in MCL, which is characterized by down-regulation of dCK and up-regulation of SPIB resulting in high NF-?B activity | Freiburghaus C, Emruli VK, Johansson A, Eskelund CW, Grønbæk K, Olsson R, Ek F, Jerkeman M, Ek S | 2018 | BMC Cancer | Oncology | Classifier, Cytonuclear | HALO |
The novel ATM inhbitior (AZ31) enhances antitumor activity in patient derived xenografts that are resistant to irinotecan montherapy | Greene J, Nguyen A, Bagby SM, Jones GN, Tai WM, Quackenbush KS, Schreiber A, Messersmith WA, Devaraj KM, Blatchford P, Eckhardt SG, Cadogan EB, Hughes GD, Smith A, Pitts TM, Arcaroli JJ | 2018 | Oncotarget | Oncology | Classifier, Area Quantification, Cytonuclear | HALO |
Cystic fibrosisrelated diabetes is caused by islet loss and inflammation | Hart NJ, Aramandla R, Poffenberger G, Fayolle C, Thames AH, Bautista A, Spigelman AF, Babon JAB, DeNicola ME, Dadi PK, Bush WS, Balamurugan AN, Brissova M, Dai C, Prasad N, Bottino R, Jacobson DA, Drumm ML, Kent SC, MacDonald PE, Powers AC | 2018 | JHI Insights | Immunology, Metabolism, Fibrosis | Cytonuclear | HALO |
Attenuation of diet-induced hypotalamic inflammation following bariatric surgery in female mice | Herrick MK, Favela KM, Simerly RB, Abumrad NN, Bingham NC | 2018 | Molecular Medicine | Immunology, Neuroscience | Cytonuclear | HALO |
pRAD50: a novel and clinically applicable pharmacodynamic biomarker of both ATM and ATR inhibition identified using mass spectrometry and immunohistochemistry | Jones GN, Rooney C, Griffin N, Roudier M, Young LA, Garcia-Trinidad A, Hughes GD, Whiteaker JR, Wilson Z, Odedra R, Zhao L, Ivey RG, Howat WJ, Harrington EA, Carrett JC, Ramos-Montoya A, Lau A, Paulovich AG, Cadogan EB, Pierce AJ | 2018 | British Journal of Cancer | Oncology | Classifier, Cytonuclear | HALO |
Mice harboring the human SLC30A8 R138X loss-of-function mutation have increased insulin secretory capacity | Kleinera S, Gomeza D, Megraa B, Naa E, Bhavsara R, Cavinoa K, Xina Y, Rojasa J, Dominguez-Gutierreza G, Zambrowicza B, Carratb G, Chabosseaub P, Hub M, Murphya AJ, Yancopoulosa GD, Rutterb GA, Gromadaa J | 2018 | Proceedings of the National Academy of Sciences | Metabolism | Cytonuclear | HALO |
TGF? inhibition restores a regenerative response in acute liver injury by suppressing paracrine senescence | Bird TG, Müller M, Boulter L, Vincent DF, Ridgway RA, Elena Lopez-Guadamillas E, Lu W-Y, Jamieson T, Govaere O, Campbell AD, Ferreira-Gonzalez S, Cole AM, Hay T, Simpson KJ, Clark W, Hedley A, Clarke M, Gentaz P, Nixon C, Bryce S, Kiourtis C, Sprangers J, Nibbs RJB, Van Rooijen N, Bartholin L, McGreal SR, Apte U, Barry ST, Iredale JP, Clarke AR, Serrano M, Roskams TA, Sansom OJ, Forbes SJ | 2018 | Science Translational Medicine | Metabolism | ISH/FISH | HALO |
Food Perception Primes Hepatic ER Homeostasis via Melanocortin-Dependent Control of mTOR Activation | Brandt C, Nolte H, Henschke S, Ruud LE, Awazawa M, Morgan DA, Gabel P, Sprenger H-G, Hess ME, Günther S, Langer T, Rahmouni K, Fenselau H, Krüger M, Brüning JC | 2018 | Cell | Neuroscience, Metabolism | ISH/FISH | HALO |
Gene Signature of Proliferating Human Pancreatic ?-Cells | Dominguez Gutierrez G, Xin Y, Okamoto H, Kim J, Lee A-H, Ni M, Adler C, Yancopoulos GD, Murphy AJ, Gromada J | 2018 | Endocrionology | Metabolism | ISH/FISH | HALO |
A phase II study of the dual mTOR inhibitor MLN0128 in patients with metastatic castration resistant prostate cancer | Graham L, Banda K, Torres A, Carver BS, Chen Y, Pisano K, Shelkey G, Curley T, Scher HI, Lotan TL, Hsieh AC, Rathkopf DE | 2018 | Investigational New Drugs | Oncology | ISH/FISH | HALO |
Ultrasensitive automated RNA in situ hybridization for kappa and lambda light chain mRNA detects B-cell clonality in tissue biopsies with performance comparable or superior to flow cytometry | Guo L, Wang Z, Anderson CA, Doolittle E, Kernag S, Cotta CV, Ondrejka SL, Ma X-J, Cook JR | 2018 | Modern Pathology | Other | Classifier, ISH/FISH | HALO |
CD163+ macrophages promote angiogenesis and vascular permeability accompanied by inflammation in atherosclerosis | Guo L, Akahori H, Harari E, Smith SL, Polavarapu R, Karmali V, Otsuka F, Gannon RL, Braumann RE, Dickinson MH, Gupta A, Jenkins AL, Lipinski MJ, Kim J, Chhour P, de Vries PS, Jinnouchi H, Kutys R, Mori H, Kutyna MD, Torii S, Sakamoto A, Choi CU, Cheng Q, Grove M, Mariem A. Sawan MA, Zhang Y, Cao Y, Kolodgie FD, Cormode DP, Arking DE, Boerwinkle E, Morrison AC, Erdmann J, Sotoodehnia N, Virmani R, and Finn AV | 2018 | The Journal of Clinical Investigation | Immunology | Layer Thickness | HALO |
Glucagon contibutes to liver zonation | Cheng X, Kim SK, Okamoto H, Xin Y, Yancopoulos GD, Murphy AJ, Gromada J | 2018 | Proceedings of the National Academy of Sciences | Metabolism | Area Quantification | HALO |
Evaluation of PD-L1 expression on vortex-isolated circulating tumor cells in metastatic lung cancer | Dhar M, Wong J, Che J, Matsumoto M, Grogan T, Elashof D, Garon EB, Goldman JW, Christen ES, Carlo DD, Kulkarni RP | 2018 | Scientific Reports | Oncology, Immuno-oncology | Area Quantification | HALO |
Digital image analysis of Ki67 proliferation index in breast cancer using virtual dual staining on whole tissue sections: clinical validation and inter?platform agreement | Koopman T, Buikema HJ, Hollema H, de Bock GH, van der Vegt B | 2018 | Breast Cancer Research and Treatment | Oncology | Classifier, Cytonuclear | HALO |
The neurotrophic tyrosine kinase receptor TrkA and its ligand NGF are increased in squamous cell carcinomas of the lung | Gao F, Griffin N, Faulkner S, Rowe CW, Williams L, Roselli S, Thorne RF, Ferdoush A, Jobling P, Walker MM, Hondermarck H | 2018 | Scientific Reports | Oncology | Area Quantification | HALO |
Ovarian Tumor Microenvironment Signaling: Convergence on the Rac1 GTPase | Hudson LG, Gillette JM, Kang H, Rivera MR, Wandinger-Ness A | 2018 | Cancers | Review | Classifier, Cytonuclear, Figure Maker | HALO |
A murine glaucoma model induced by rapid in vivo photopolymerization of hyaluronic acid glycidyl methacrylate | Guo C, Qu X, Rangaswamy N, Leehy B, Xiang C, Rice D, Prasanna G | 2018 | PLOS One | Biomaterials | Area Quantification | HALO |
Systemic messenger RNA as an etiological treatment for acute intermittent porphyria | Jiang L, Berraondo P, Jericó D, Guey LT, Sampedro A, Frassetto A, Benenato KE, Burke K, Santamaría E, Alegre M, Pejenaute A, Kalariya M, Butcher W, Park JS, Zhu X, Sabnis S, Kumarasinghe ES, Salerno T, Kenney M, Lukacs CM, Ávila MA, Martini PGV, Fontanellas A | 2018 | Nature Medicine | Metabolism | Area Quantification | HALO |
Tumor Microenvironment in Functional Adrenocortical Adenomas: Immune Cell Infiltration in Cortisol-producing Adrenocortical Adenoma | Kitawaki Y, Nakamura Y, Kubota-Nakayama F, YamazakiY, Miki Y, Hata S, Ise K, Kikuchie K, MorimotoR, Satoh F, Sasano H | 2018 | Human Pathology | Oncology, Immuno-oncology | Area Quantification | HALO |
Up-Regulation of Iba-1 and GFAP in the Acidic Saline Model of Chronic Widespread Musculoskeletal Pain: A Pilot Study Examining the Relationship Between Gliosis and Hyperalgesia | Lambert DM, Kumar U, Hafell UO | 2018 | Journal of Neuroscience and Neuropharmacology | Neuroscience | Area Quantification, Partitions (tiles, margins) | HALO |
Tough Composite Hydrogels with High Loading and Local Release of Biological Drugs | Li J, Weber E, Guth?Gundel S, Schuleit M, Kuttler A, Halleux C, Accart N, Doelemeyer A, Basler A, Tigani B, Wuersch K, Fornaro M, Kneissel M, Stafford A, Freedman BR, Mooney DJ | 2018 | Advanced Healthcare Materials | Biomaterials | Area Quantification | HALO |
Blocking HIF signaling via novel inhibitors of CA9 and APE1/Ref-1 dramatically affects pancreatic cancer cell survival | Logsdon DP, Fenil S, Fabrizio C, Supuran CT, Kamocka M, Jacobsen MH, Sandusky GE, Kelley MR, Fishel ML | 2018 | Scientific Reports | Oncology | Classifier, Cytonuclear | HALO |
Diet-Induced Growth Is Regulated via Acquired Leptin Resistance and Engages a PomcSomatostatin-Growth Hormone Circuit | Lohr H, Hess S, Pereira MMA, Reino P, Leibold S, Schenkel C, Wunderlich CM, Kloppenburg P, Bruning JC, Hammerschmidt M | 2018 | Cell Reports | Neuroscience, Metabolism | Cytonuclear | HALO |
Chronic Intermittent Hypoxia Induces Robust Astrogliosis in an Alzheimer's Disease-Relevant Mouse Model | Macheda T, Roberts K, Lyons DN, Higgins E, Ritter KJ, Lin A-L, Alilain WJ, Bachstetter AD | 2018 | Neuroscience | Neuroscience | Area Quantification | HALO |
Cellular milieu imparts distinct pathological ?-synuclein strains in ?-synucleinopathies | Peng C, Gathagan RJ, Covell DJ, Medellin C, Stieber A, Robinson JL, Zhang B, Pitkin RM, Olufemi MF, Luk KC, Trojanowski JQ, Lee VM-Y | 2018 | Nature | Neuroscience | Area Quantification | HALO |
Differential ?-synuclein expression contributes to selective vulnerability of hippocampal neuron subpopulations to fibril-induced toxicity | Luna E, Decker SC, Riddle DM, Caputo A, Zhang B, Cole T, Caswell C, Xie SX, Lee VMY, Luk KC | 2018 | Acta Neuopathologica | Neuroscience | Area Quantification, Cytonuclear | HALO |
Digital image analysis improves precision of PD?L1 scoring in cutaneous melanoma | Koelzer VH, Gisler A, Hanhart JC, Griss J, Wagner SN, Willi N, Cathomas G, Sachs M, Kempf W, Thommen DS, Mertz KD | 2018 | Histopathology | Oncology, Immuno-oncology | Classifier, Multiplex IHC | HALO |
Lenvatinib inhibits angiogenesis and tumor fibroblast growth factor signaling pathways in human hepatocellular carcinoma models | Matsuki M, Hoshi T, Yamamoto Y, Ikemori-Kawada M, Minoshima Y, Funahashi Y, Matsui J | 2018 | Cancer Medicine | Oncology | Cytonuclear | HALO |
Hot Spot and Whole-Tumor Enumeration of CD8(+) Tumor-Infiltrating Lymphocytes Utilizing Digital Image Analysis Is Prognostic in Triple-Negative Breast Cancer | McIntire PJ, Irshaid L, Liu Y, Chen Z, Menken F, Nowak E, Shin SJ, Ginter PS | 2018 | Clinical Breast Cancer | Oncology, Immuno-oncology | Cytonuclear, Figure Maker | HALO |
Altered dopaminergic regulation of the dorsal striatum is able to induce tic-like movements in juvenile rats | Nespoli E, Rizzo F, Boeckers T, Schulze U, Hengerer B | 2018 | PLOS One | Neuroscience | Cytonuclear | HALO |
Induction of hemangiosarcoma in mice after chronic treatment with S1P-modulator siponimod and its lack of relevance to rat and human | Pognan F, Mahl JA, Papoutsi M, David Ledieu D, Raccuglia M, Theil D, Voytek SB, Devine PJ, Kubek?Luck K, Claudio N, Cordier A, Heier A, Kolly C, Hartmann A, Chibout S-D, Bouchard P, Trendelenburg C | 2018 | Archives of Toxicology | Toxicology | Classifier, Cytonuclear | HALO |
Intermittent Hypoxia Exacerbates Increased Blood Pressure in Rats with Chronic Kidney Disease | Riggs J, Pace C, Ward HH, Gonzalez Bosc L, Rios L, Barrera A, Kanagy NL | 2018 | American Jornal of Physiology-Renal Physiology | Metabolism | Classifier, Cytonuclear | HALO |
Mild Impairment of Mitochondrial OXPHOS Promotes Fatty Acid Utilization in POMC Neurons and Improves Glucose Homeostasis in Obesity | Timper K, Paeger L, Sánchez-Lasheras C, Varela L, Jais A, Nolte H, Vogt MC, Hausen AC, Heilinger C, Evers N, Pospisilik JA, Penninger JM, Taylor EB, Horvath TL, Kloppenburg P, Brüning JC | 2018 | Cell Repots | Neuroscience, Metabolism | Cytonuclear | HALO |
Biomarker Evaluation and Toxic Effects of an Acute Oral and Systemic Fumonisin Exposure of Pigs with a Special Focus on Dietary Fumonisin Esterase Supplementation | Schertz H, Danicke S, Frahm J, Schatzmayr D, Dohnal I, Bichl G, Schwartz-Zimmerman HE, Colicchia S, Breves G, Teifke JP, Kluess J | 2018 | Toxins | Toxicology | Classifier | HALO |
Mutant myocilin impacts sarcomere ultrastructure in mouse gastrocnemius muscle | Lynch JM, Dolman AJ, Guo C, Dolan K, Xiang C, Reda S, Li B, Prasanna G | 2018 | PLOS One | Gastroenterology, Myology | ISH/FISH | HALO |
Breast and pancreatic cancer interrupt IRF8-dependent dendritic cell development to overcome immune surveillance | Meyer MA, Baer JM, Knolhoff BL, Nywening TM, Panni RZ, Su X, Weilbaecher KN, Hawkins WG, Ma C, Fields RC, Linehan DC, Challen GA, Faccio R, Aft RL, DeNardo DG | 2018 | Nature Communications | Oncology, Immuno-oncology | ISH/FISH | HALO |
What is the added value of digital image analysis of HER2 immunohistochemistry in breast cancer in clinical practice? A study with multiple platforms | Koopman T, Buikema HJ, Hollema H, de Bock GH, van der Vegt B | 2018 | Histopathology | Oncology | Membrane | HALO |
Tumor Cell Subtypes Based on the Intracellular Hormonal Activity in KCNJ5-Mutated Aldosterone-Producing Adenoma | Yamazaki Y, Omata K, Tezuka Y, Ono Y, Morimoto R, Adachi Y, Ise K, Nakamura Y, Gomez-Sanchez CE, Shibahara Y, Kitamoto T, Nishikawa T, Ito S, Satoh F, Sasano H | 2018 | Hypertension | Oncology | Area Quantification, Cytonuclear | HALO |
Disease Progression and Pharmacological Intervention in a Nutrient-Deficient Rat Model of Nonalcoholic Steatohepatitis | Tølbøl KS, Stierstorfer B, Rippmann JF, Veidal SS, Rigbolt KTG, Schönberger T, Gillum MP, Hansen HH, Vrang N, Jelsing J, Feigh M, Broermann A | 2018 | Digestive Diseases and Sciences | Metabolism | Area Quantification | HALO |
FOXM1 contributes to treatment failure in acute myeloid leukemia | Khan I, Halasi M, Patel A, Schultz R, Kalakota N, Chen Y-H, Aardsma N, Liu L, Crispino JD, Mahmud N, Frankfurt O, Gartel AL | 2018 | JCI Insight | Oncology | Multiplex IHC | HALO |
A transcriptionally and functionally distinct PD-1+ CD8+ T cell pool with predictive potential in non-small-cell lung cancer treated with PD-1 blockade | Thommen DS, Koelzer VH, Herzig P, Roller A, Trefny M, Dimeloe S, Kiialainen A, Hanhart J, Schil C, Hess C, Prince SS, Wiese M, Lardinois D, Ho P-C, Klein C, Karanikas V, Mertz KD, Schumacher TN, Zippelius A | 2018 | Nature Medicine | Oncology, Immuno-oncology | Multiplex IHC | HALO |
Relationship between mismatch repair immunophenotype and long-term survival in patients with resected periampullary adenocarcinoma | Heby M, Lundgren S, Nodin B, Elebro J, Eberhard J, Jirström K | 2018 | Journal of Translational Medicine | Oncology, Immuno-oncology | Object Colocalization | HALO |
Luminally-polarized mural and vascular remodeling in ileal strictures of Crohn's Disease | Zhang X, Ko HM, Torres J, Panchal HJ, Cai Z, WagneR M, Sands BE, Colombel J-F, Cho J, Taouli B, Harpaz N | 2018 | Human Pathology | Immunology | Layer Thickness | HALO |
Age-related pathology after adenoviral overexpression of the leucine-rich repeat kinase 2 in the mouse striatum | Kritzingerab A, Ferger B, Gillardon F, Stierstorfer B, Birk G, Kochanek S, Ciossek T | 2018 | Neurobiology of Aging | Neuroscience | Area Quantification, Object Colocalization, Microglia | HALO |
Pharmacogenetic neuronal stimulation increases human tau pathology and trans-synaptic spread of tau to distal brain regions in mice | Schultz MK, Gentzel R, Usenovic M, Gretzul C, Ware C, Parmentier-Batteur S, Schachter JB, Zariwala HA | 2018 | Neurobiology of Disease | Neuroscience | Object Colocalization | HALO |
Comparison of Biologic Effect and Particulate Embolization after Femoral Artery Treatment with Three Drug-Coated Balloons in Healthy Swine Model | Torii S, Jinnouchi H, Sakamoto A, Romero ME, Kolodgie FD, Virmani R, Finn AV | 2018 | Journal of Vascular and Interventional Radiology | Other | Object Colocalization | HALO |
Multidimensional, quantitative assessment of PD-1/PD-L1 expression in patients with Merkel cell carcinoma and association with response to pembrolizumab | Giraldo NA, Nguyen P, Engle EL, Kaunitz GJ, Cottrell TR, Berry S, Green B, Soni A, Cuda JD, Stein JE, Sunshine JC, Succaria F, Xu H, Ogurtsova A, Danilova L, Church CD, Miller NJ, Fling S, Lundgren L, Ramchurren N, Yearley JH, Lipson EJ, Cheever M, Anders RA, Nghiem PT, Topalian SL, Taube JM | 2018 | Journal for ImmunoTherapy of Cancer | Oncology, Immuno-oncology | Spatial Analysis, Serial Section | HALO |
A CD3-bispecific molecule targeting P-cadherin demonstrates T cell-mediated regression of established solid tumors in mice | TS Fisher, AT Hooper, J Lucas, TH Clark, AK Rohner, B Peano, MW Elliott, K Tsaparikos, H Wang, J Golas, M Gavriil, N Haddish-Berhane, L Tchistiakova, H-P Gerber, AR Root, C May | 2018 | Cancer Immunology, Immunotherapy | Oncology, Immuno-oncology | Area Quantification | HALO |
Innate Sex Bias of Staphylococcus aureus Skin Infection Is Driven by a-Hemolysin | Castleman MJ, Pokhrel S, Triplett KD, Kusewitt DF, Elmore BO, Joyner JA, Femling JK, Sharma G, Hathaway HJ, Prossnitz ER, Hall PR | 2018 | The Journal of Immunology | Infectious Disease | HALO | |
Subclonal evolution of pulmonary adenocarcinomas delineated by spatially distributed somatic mitochondrial mutations | Kazdal D, Harms A, Endris V, Penzel R, Kriegsmann M, Eichhorn F, Muley T, Stenzinger A, Pfarr N, Weichert W, and Warth A | 2018 | Lung Cancer | HALO | ||
Molecular and immunologic analysis of laryngeal squamous cell carcinoma in smokers and non-smokers | Malm I-J, rooper LM, Bishop JA, Ozgursoy SK, Hillel AT, Akst LM, Best SR | 2018 | American Journal of Otolaryngology | Oncology, Immuno-oncology | HALO | |
Class 4 Semaphorins and Plexin-B receptors regulate GABAergic and glutamatergic synapse development in the mammalian hippocampus | McDermott JE, Goldblatt D, Paradis S | 2018 | Molecular and Cellular Neuroscience | Neuroscience | HALO | |
Acquired cancer resistance to combination immunotherapy from transcriptional loss of class I HLA | Paulson KG, Voillet V, McAfee MS, Hunter DS, Wagener FD, Perdicchio, Valente WJ, Koelle SJ, Church CD, Vandeven N, Thomas H, Colunga AG, Iyer JG, Yee C, Kulikauskas R, Koelle DM, Pierce RH, Bielas JH, Greenberg PD, Bhatia S, Gottardo R, Nghiem P, Chapuis AG | 2018 | Nature Communications | Immuno-oncology | Partitions (tiles, margins), Figure Maker | HALO |
Digital image analysis supports a nuclear-to-cytoplasmic ratio cutoff value below 0.7 for positive for high-grade urothelial carcinoma and suspicious for high-grade urothelial carcinoma in urine cytology specimens | McIntire PJ, Snow JT, Elsoukkary SS, Soong L, Sweeney J, Robinson BD, Siddiqui MT | 2018 | Cancer Cytopathology | Oncology | HALO | |
Ossabaw Pigs With a PCSK9 Gain?of?Function Mutation Develop Accelerated Coronary Atherosclerotic Lesions: A Novel Model for Preclinical Studies | Yuan F, Guo L, Park K-H, Woollard JR, Taek?Geun K, Jiang K, Melkamu T, Zang B, Smith SL, Fahrenkrug SC, Kolodgie FD, Lerman A, Virmani R, Lerman LO, Carlson DF | 2018 | Journal of the American Heart Association | Myology | Area Quantification | HALO |
Accelerated wound healing by injectable star poly(ethylene)-b-poly(propylene sulfide) scaffolds loaded with poorly water-soluble drugs | Zhu X, Yin L, Theisen M, Zhuo J, Siddiqui S, Levy B, Presnyak V, Frassetto A, Milton J, Salerno T, Benenato KE, Milano J, Lynn A, Sabnis S, Burke K, Besin G, Lukacs CM, Guey LT, Finn PF, Martini PGV | 2018 | Journal of Controlled Release | Biomaterials, Wound Healing | Cytonuclear | HALO |
The use of automated Ki67 analysis to predict Oncotype DX risk-of-recurrence categories in early-stage breast cancer | Thakur SS, Li H, Chan AMY, Tudor R, Bigras G, Morris D, Enwere EK | 2018 | PLOS ONE | Oncology | Cytonuclear, Figure Maker, Partitions (tiles, margins) | HALO |
Inhibiting Interleukin 36 Receptor Signaling Reduces Fibrosis in Mice with Chronic Intestinal Inflammation | Scheibe K, Kersten C, Schmied A, Vieth M, Primbs T, Carlé B, Knieling F, Claussen J, Klimowicz AC, Zheng J, Baum P, Meyer S, Schürmann S, Friedrich O, Waldner MJ, Rath T, Wirtz S, Kollias G, Ekici AB, Atreya R, Raymond EL, Mbow ML, Neurath MF, Neufert C | 2018 | Gastroenterology | Immunology, Fibrosis | HALO | |
Low and variable tumor reactivity of the intratumoral TCR repertoire in human cancers | Scheper W, Kelderman S, Fanchi LF, Linnemann C, Bendle G, de Rooij MAJ, Hirt C, Mezzadra R, Slagter M, Dijkstra K, Kluin RJC, Snaebjornsson P, Milne K, Nelson BH, Zijlmans H, Kenter G, Voest EE, Haanen JBAG, Schumacher TN | 2018 | Nature Medicine | Oncology, Immuno-oncology | Cytonuclear | HALO |
A suboptimal maternal diet combined with accelerated postnatal growth results in an altered aging profile in the thymus of male rats | Tarry-Adkins JL, Aiken CE, Ashmore TJ, Fernandez-Twinn DS, Chen J-H, Ozanne SE | 2018 | The FASEB Journal | Neuroscience, Metabolism | Classifier, Vacuole | HALO |
A brain-penetrant triazolopyrimidine enhances microtubule-stability, reduces axonal dysfunction and decreases tau pathology in a mouse tauopathy model. | Zhang B, Yao Y, Cornec A-S, Oukoloff K, James MJ, Koivula P, Trojanowski JQ, Smith AB III, Lee VM-Y, Ballatore C, Brunden KR | 2018 | Molecular Neurodegeneration | Neuroscience | Area Quantification | HALO |
GABA promotes ?-cell proliferation, but does not overcome impaired glucose homeostasis associated with diet-induced obesity | Untereiner A, Abdo S, Bhattacharjee A, Gohil H, Pourasgari F, Ibeh N, Lai M, Batchuluun B, Wong A, Khuu N, Liu Y, Rijjal DA, Winegarden N, Virtanen C, Orser BA, Cabrera O, Varga G, Rocheleau J, Dai FF, Wheeler MB | 2018 | The FASEB Journal | Metabolism | Cytonuclear | HALO |
Ki67 reproducibility using digital image analysis: an inter-platform and inter-operator study | Acs B, Pelekanou V, Bai Y, Martinez-Morilla S, Toki M, Leung SCY, Nielsen TO, Rimm DL | 2017 | Laboratory Invesigations | Oncology | Classifier, Cytonuclear | HALO |
Efficacy of injectable praziquantel for elimination of trematode metacercariae in bluegills (Lepomis macrochirus) and quantification of parasite death by propidium iodide staining | Bader C, Chelladurai JJ, Starling DE, Jones DE, Brewer MT | 2017 | Parasitology Research | Infectious Disease | Area Quantification | HALO |
Both brown adipose tissue and skeletal muscle thermogenesis processes are activated during mild to severe cold adaptation in mice | Bal NC, Singh S, Reis FCG, Maurya SK, Pani S, Rowland LA, Periasamy M | 2017 | Journal of Biological Chemistry | Myology | Area Quantification | HALO |
Sex- and Dose-Specific Effects of Maternal Bisphenol A Exposure on Pancreatic Islets of First- and Second-Generation Adult Mice Offspring | Bansal A, Rashid C, Xin F, Li C, Polyak E, Duemler A, van der Meer T, Stefaniak M, Wajid S, Doliba N, Bartolomei MS, Simmons RA | 2017 | Environmental Health Perspectives | Metabolism | Area Quantification | HALO |
The R-enantiomer of ketorolac delays mammary tumor development in mouse mammary tumor virus-polyoma middle T antigen (MMTV-PyMT) mice | AS Peretti, D Dominguez, MM Grimes, HJ Hathaway, ER Prossnitz, MR Rivera, A Wandinger-Ness, D Kusewitt, LG Hudson | 2017 | The American Journal of Pathology | Oncology | Classifier, Area Quantification, Cytonuclear | HALO |
The clinical impact of tumour-infiltrating lymphocytes in colorectal cancer differs by anatomical subsite: A cohort study | Berntsson J, Svensson MC, Leandersson K, Nodin B, Micke P, Larsson AH, Eberhard J, Jirstrom K | 2017 | International Journal of Cancer | Oncology, Immuno-oncology | Cytonuclear | HALO |
Acetate Recapturing by Nuclear Acetyl-CoA Synthetase 2 Prevents Loss of Histone Acetylation during Oxygen and Serum Limitation | Bulusu V, Tumanov S, Michalopoulou E, van den Broek NJ, MacKay G, Nixon C, Dhayade S, Schug ZT, Voorde JV, Blyth K, Gottlieb E, Vazquez A, Kamphorst JJ | 2017 | Cell Reports | Oncology, Metabolism | Cytonuclear | HALO |
Loss of the imprinted, non-coding Snord116 gene cluster in the interval deleted in the Prader Willi syndrome results in murine neuronal and endocrine pancreatic developmental phenotypes | Burnett LC, Hubner G, LeDuc C, Morabito MV, Carli JFM, Leibel RL | 2017 | Human Moledular Genetics | Metabolism | Cytonuclear | HALO |
Identification of the SUMO E3 ligase PIAS1 as a potential survival biomarker in breast cancer | Chanda A, Chan A, Deng L, Kornaga EN, Enwere EK, Morris DG, Bonni S | 2017 | PLOS One | Oncology | Classifier, Cytonuclear | HALO |
Spatial distribution of EGFR and KRAS mutation frequencies correlates with histological growth patterns of lung adenocarcinomas | Dietz S, Harms A, Endris V, Eichhorn, Kriegsmann M, Longuespée R, Stenzinger A, Sültmann H, Warth A, and Kazdal D | 2017 | International Journal of Cancer | Oncology | Cytonuclear | HALO |
Aging African green monkeys manifest transcriptional, pathological, and cognitive hallmarks of human Alzheimer's disease | Cramer PE, Gentzel RC, Tanis KQ, Vardigan J, Wang Y, Connolly B, Manfre P, Lodge K, Renger JJ, Zerbinatti C, Uslaner JM | 2017 | Neurobiology of Aging | Neuroscience | Object Colocalization | HALO |
Retinoic-acid-orphan-receptor-C inhibition suppresses Th17 cells and induces thymic aberrations | Guntermann C, Piaia A, Hamel M-L, Theil D, Rubic-Schneider T, del Rio-Espinola A, Dong L, Billich A, Kaupmann K, Dawson J, Hoegenauer K, Orain D, Hintermann S, Stringer R, Pate DD, Doelemeyer A, Deurinck M, and Schümann J | 2017 | JCI Insight | Oncology, Immuno-oncology | Area Quantification, Cytonuclear | HALO |
Digital image analysis agrees with visual estimates of bone marrow trephine biopsy cellularity | Hagiya AS, Etman A, Siddiqi IN, Cen S, Matcuk Jr GR, Brynes RK, Salama ME | 2017 | International Journal of Laboratory Hematology | Oncology | Cytonuclear | HALO |
Selective imaging of internalized proteopathic ?-synuclein seeds in primary neurons reveals mechanistic insight into transmission of synucleinopathies | Karpowicz RJ, Haney CM, Mihaila TS, Sandler RM, Petersson EJ, and Lee VM-Y | 2017 | Journal of Biological Chemistry | Neuroscience | Area Quantification, Cytonuclear | HALO |
Prevalence of somatic mitochondrial mutations and spatial distribution of mitochondria in non-small cell lung cancer | Kazdal D, Harms A, Endris V, Penzel R, Oliveira C, Kriegsmann M, Longuespee R, Winter H, Schneider MA, Muley T, Pfarr N, Weichert W, Stenzinger A,Warth A | 2017 | British Journal of Cancer | Oncology | Cytonuclear | HALO |
Amino Acid Transporter Slc38a5 Controls Glucagon Receptor Inhibition-Induced Pancreatic ? Cell Hyperplasia in Mice | Kim J, Okamoto H, Huang ZJ, Anguiano G, Chen S, Liu Q, Cavino K, Xin Y, Na E, Hamid R, Lee J, Zambrowicz B, Unger R, Murphy AJ, Xu Y, Yancopoulos GD, Li W, Gromada J | 2017 | Cell Metabolism | Metabolism | Cytonuclear | HALO |
APNG as a prognostic marker in patients with glioblastoma | Fosmark S, Hellwege S, Dahlrot RH, Jensen KL, Derand H, Lohse J, Sørensen MD, Hansen S, Kristensen BW | 2017 | PLOS One | Oncology | ISH/FISH | HALO |
TGF? pathway limits dedifferentiation following WNT and MAPK pathway activation to suppress intestinal tumourigenesis | Cammareri P, Vincent DF, Hodder MC, Ridgway RA, Murgia C, Nobis M, Campbell AD, Varga J, Huels DJ, Subramani C, Prescott KLH, Nixon C, Hedley A, Barry ST, Greten FR, Inman GJ, and Sansom OJ | 2017 | Cell Death and Differentiation | Oncology | Layer Thickness | HALO |
Digital analysis and epigenetic regulation of the signature of rejection in colorectal cancer | Koelzer VH, Sokol L, Zahnd S, Christe L, Dawson H, Berger MD, Inderbitzin D, Zlobec I, Lugli A | 2017 | OncoImmunology | Oncology | Cytonuclear | HALO |
Asymmetry of post-mortem neuropathology in behavioural-variant frontotemporal dementia | DJ Irwin, CT McMillan, SX Xie, K Rascovsky, VM Van Deerlin, HB Coslett, R Hamilton, G Aguirre, EB Lee, VMY Lee, JQ Trojanowski, M Grossman | 2017 | Brain | Neuroscience | Area Quantification, Partitions (tiles, margins) | HALO |
Co-clinical Analysis of a Genetically Engineered Mouse Model and Human Prostate Cancer Reveals Significance of NKX3.1 Expression for Response to 5?-reductase Inhibition | Dutta A, Panja S, Virk RK, Kim JY, Zott R, Cremers S, Golombos DM, Liu D, Mosquera JM, Mostaghel EA, Barbieri CE, Mitrofanova A, Abate-Shen C | 2017 | European Urology | Oncology | Area Quantification | HALO |
Amyloid-? plaques enhance Alzheimer's brain tau-seeded pathologies by facilitating neuritic plaque tau aggregation | He Z, Guo JL, McBride JD, Narasimhan S, Kim H, Changolkar L, Zhang B, Gathagan RJ, Yue C, Dengler C, Stieber A, Nitla M, Coulter DA, Abel T, Brunden KR, Trojanowski JQ, Lee V M-Y | 2017 | Nature Medicine | Neuroscience | Area Quantification | HALO |
An ancestral retroviral protein identified as a therapeutic target in type-1 diabetes | Levet S, Medina J, Joanou J, Demolder A, Queruel N, Réant K, Normand M, Seffals M, Dimier J, Germi R, Piofczyk T, Portoukalian J, Touraine J-L, Perron H | 2017 | JCI Insight | Immunology, Metabolism | Classifier, Cytonuclear | HALO |
Receptor tyrosine kinase expression and phosphorylation in canine nasal carcinoma | Hocker SA, Higginbotham ML, Schermerhorn T, Henningson J | 2017 | Research in Veterinary Science | Oncology | Area Quantification, Multiplex IHC | HALO |
Differential roles of RET isoforms in medullary and papillary thyroid carcinomas | Lian EY, Maritan SM, Cockburn JG, Kasaian K, Crupi MJF, Hurlbut D, Jones SJM, Wiseman SM, Mulligan LM | 2017 | Endocrine-Related Cancer | Oncology | Cytonuclear | HALO |
Ante mortem CSF tau levels correlate with post mortem tau pathology in FTLD | Irwin DJ, Lleó A, Xie SX, McMillan CT, Wolk D, Lee EB, Van Deerlin VM, Shaw LM, Trojanowski JQ, Grossman M | 2017 | Annals of Neurology | Neuroscience | Area Quantification | HALO |
Neutorphils dominate the immune cell composition in non-small cell lung cancer | Kargl J, Busch SE, Yang GHY, Kim K-H, Hanke ML, Metz HE, Hubbard JJ, Lee SM, Madtes DK, McIntosh MW, Houghton AM | 2017 | Nature Communications | Oncology | Area Quantification | HALO |
DPP9 enzyme activity controls survival of mouse migratory tongue muscle progenitors and its absence leads to neonatal lethality due to suckling defect | Kim M, Minoux M, Piaia A, Kueng B, Gapp B, Weber D, Haller C, Barbieri S, Namoto K, Lorenz T, Wirsching J, Bassilana F, Dietrich W, Rijli FM, Ksiazek I | 2017 | Developmental Biology | Myology | Classifier, Area Quantification | HALO |
Connexin-43 and aquaporin-4 are markers of ageing-related tau astrogliopathy (ARTAG)-related astroglial response | Kovacs GG, Yousef A, Kaindl S, Lee VM, Trojanowski JQ | 2017 | Neuropathology and Applied Neurobiology | Neuroscience | Area Quantification | HALO |
Angptl4 does not control hyperglucagonemia or ?-cell hyperplasia following glucagon receptor inhibition | Okamoto H, Cavino K, Na E, Krumm E, Kim SY, Stevis PE, Harp J, Murphy AJ, Yancopoulos GD, Gromada J | 2017 | Proceedings of the National Academy of Sciences | Metabolism | Area Quantification | HALO |
Glucagon receptor inhibition normalizes blood glucose in severe insulin-resistant mice | Okamoto H, Kim J, Aglione JP, Lee J, Cavino K, Na E, Rafique A, Kim JH, Harp J, Valenzuela DM, Yancopoulos GD, Murphy AJ, Gromada J | 2017 | Proceedings of the National Academy of Sciences | Metabolism | Area Quantification | HALO |
Cysteinyl leukotriene receptor 1 facilitates tumorigenesis in a mouse model of colitis-associated colon cancer | Osman J, Savari S, Chandrashekar NK, Bellamkonda K, Souglas D, Sjolander A | 2017 | Oncotarget | Oncology, Immunology | Classifier, Area Quantification | HALO |
Plant-based vaccines for oral delivery of type 1 diabetes-related autoantigens: Evaluating oral tolerance mechanisms and disease prevention in NOD mice | Posgai AL, Wasserfall CH, Kwon K-C, Daniell H, Schatz DA, Atkinson MA | 2017 | Scientific Reports | Metabolism | Area Quantification | HALO |
cFOS-SOX9 Axis Reprograms Bone Marrow-Derived Mesenchymal Stem Cells into Chondroblastic Osteosarcoma | He Y, Zhu W, Shin MH, Gary J, Liu C, Dubois W, Hoover SB, Jiang S, Marrogi E, Mock B, Simpson RM, and Huang J | 2017 | Stem Cell Reports | Oncology | Classifier | HALO |
Modulating the therapeutic response of tumours to dietary serine and glycine starvation | Maddocks ODK, Athineos D, Cheung EC, Lee P, Zhang T, van den Broek NJF, Mackay GM, Labuschagne CF, Gay D, Kruiswijk F, Blagih J, Vincent DF, Campbell KJ, Ceteci F, Sansom OJ, Blyth K, Vousden KH | 2017 | Nature | Oncology | Cytonuclear | HALO |
Expression of protein disulfide isomerase family members correlates with tumor progression and patient survival in ovarian cancer | Samanta S, Tamura S, Dubeau L, Mhawech-Fauceglia P, Miyagi Y, Kato H, Lieberman R, Buckanovich RJ, Lin YG, Neamati N | 2017 | Oncotarget | Oncology | Area Quantification | HALO |
Targeting autophagy inhibits melanoma growth by enhancing NK cells infiltration in a CCL5-dependent manner | Mgrditchiana T, Arakeliana T, Paggettia J, Nomana MZ, Virya E, Moussaya E, Van Moera K, Kreisb S, Guerinc C, Buartd S, Roberte C, Borgf C, Vielhg P, Chouaibd S, Berchema G, Janji B | 2017 | Proceedings of the National Academy of Sciences | Oncology, Immuno-oncology | Cytonuclear | HALO |
Weight Pertubation Alters Leptin Signal Transduction in a Region-Specific Manner throughout the Brain | Morabito MV, Ravussin Y, Mueller BR, Skowronski AA, Watanabe K, Foo KS, Lee SX, Lehmann A, Hjorth S, ZeltserLM, LeDuc CA, Leibel RL | 2017 | PLOS One | Metabolism | Cytonuclear | HALO |
A single dose of peripherally infused EGFRvIII-directed CAR T cells mediates antigen loss and induces adaptive resistance in patients with recurrent glioblastoma | ORourke DM, Nasrallah MP, Desai A, Melenhorst JJ, Mansfield K, MorrissetteJJD, Martinez-Lage M, Brem S, Maloney E, Shen A, Isaacs R, Mohan S, Plesa G, Lacey SF, Navenot J-M, Zheng Z, Levine BL, Okada H, June CH, Brogdon JL, Maus MV | 2017 | Science Translational Medicine | Oncology, Immuno-oncology | Cytonuclear, Multiplex IHC | HALO |
The action of ?-hydroxybutyrate on the growth, metabolism and global histone H3 acetylation of spontaneous mouse mammary tumours: evidence of a ?-hydroxybutyrate paradox | Rodrigues LM, Uribe-Lewis S, Madhu B, Honess DJ, Stubbs M, Griffiths JR | 2017 | Cancer & Metabolism | Oncology, Metabolism | Area Quantification, Cytonuclear | HALO |
High levels of tumor-associated neutrophils are associated with improved overall survival in patients with stage II colorectal cancer | RS Berry, M-J Xiong, A Greenbaum, P Mortaji, RA Nofchissey, F Schultz, C Martinez, L Luo, KT Morris, JA Hanson | 2017 | PLOS One | Oncology, Immuno-oncology | Cytonuclear | HALO |
Pathological tau strains from human brains recapitulate the diversity of tauopathies in non-transgenic mouse brain | S Narasimhan, JL Guo, L Changolkar, A Stieber, JD McBride, LV Silva, Z He, B Zhang, RJ Gathagan, JQ Trojanowski, VMY Lee | 2017 | Journal of Neuroscience | Neuroscience | Cytonuclear | HALO |
T-cell Localization, Activation, and Clonal Expansion in Human Pancreatic Ductal Adenocarcinoma | Stromnes IM, Hulbert A, Pierce RH, Greenberg PD, Hingorani SR | 2017 | Cancer Immunology Research | Oncology, Immuno-oncology | Highplex FL | HALO |
Transcriptional mechanisms of resistance to anti-PD-1 therapy | Ascierto ML, Makohon-Moore A, Lipson EJ, Taube JM, McMiller TL, Berger AE, Fan J, Kaunitz GJ, Cottrell TR, Kohutek ZA, Favorov A, Makarov V, Riaz N, Chan TA, Cope L, Hruban RH, Pardoll DM, Taylor BS, Solit DB, Iacobuzio-Donahue CA, Topalian SL | 2017 | Clinical Cancer Research | Oncology, Immuno-oncology | Immune | HALO |
Comparison of branch and distally focused main renal artery denervation using two different radio-frequency systems in a porcine model | Mahfoud F, Pipenhagen CA, Moon LB, Ewen S, Kulenthiran S, Fish JM, Jensen JA, Virmani R, Joner M, Yahagi K, Tsioufis C, Böhm M | 2017 | International Journal of Cardiology | Myology | Layer Thickness | HALO |
Treatment with the WNT5A-mimicking peptide Foxy-5 effictively reduces the metastatic spread of WNT5A-low prostate cancer cells in an orthotopic mouse model | Canesin G, Evans-Axelsson S, Hellsten R, Krzyzanowska A, Prasad CP, Bjartell A, Andersson T | 2017 | PLOS One | Oncology | Membrane | HALO |
Expression of PD-L1 and presence of CD8-positive T cells in pre-treatment specimens of locally advanced cervical cancer | Enwere EK, Kornaga EN, Dean M, Koulis TA, Phan T, Kalantarian M, Köbel M, Ghatage P, Magliocco AM, Lees-Miller DP, Doll CM | 2017 | Modern Pathology | Oncology, Immuno-oncology | Membrane | HALO |
Association of HIV Status With Local Immune Response to Anal Squamous Cell Carcinoma: Implications for Immunotherapy | Yanik EL, Kaunitz GJ, Cottrell TR, Succaria F, McMiller TL, Ascierto ML, Esandrio J, Xu H, Ogurtsova A, Cornish T, Lipson EJ, Topalian SL, Engels EA, Taube JM | 2017 | JAMA Oncology | Oncology, Immuno-oncology | Cytonuclear | HALO |
Chronic Verubecestat Treatment Suppresses Amyloid Accumulation in Advanced Aged Tg2576-A?PPswe Mice Without Inducing Microhemorrhage | Villarreal S, Zhao F, Hyde LA, Holder D, Forest T, Sondey M, Chen X, Sur C, Parker EM, Kennedy ME | 2017 | Journal of Alzheime's Disease | Neuroscience | Object Colocalization | HALO |
In vivo characterization of a new type of biodegradable starch microsphere for transarterial embolization | Sommer CM, Do TD, Schlett CL, Flechsig P, Gockner TL, Kuthning A, Vollherbst DF, Pereira PL, Kauczor HU, Macher-Göppinger S | 2017 | Journal of Biomaterials Applications | Oncology | Classifier | HALO |
A randomized, open-label study of the efficacy and safety of AZD4547 monotherapy versus paclitaxel for the treatment of advanced gastric adenocarcinoma with FGFR2 polysomy or gene amplification | Van Cutsem E, Bang Y-J, Mansoor W, Petty RD, Chao Y, Cunningham D, Ferry DR, N. R. Smith NR, Frewer P, Ratnayake J, Stockman PK, Kilgour E, and Landers D | 2017 | Annals of Oncology | Oncology | Classifier, ISH/FISH | HALO |
Persistence of Pancreatic Insulin mRNA Expression and Proinsulin Protein in Type 1 Diabetes Pancreata | Wasserfall C, Nick HS, Campbell-Thompson M, Beachy D, Haataja L, Kusmartseva I, Posgai A, Beery M, Rhodes C, Bonifacio E, Arvan P, Atkinson M | 2017 | Cell Metabolism | Metabolism | Area Quantification | HALO |
Neuron loss and degeneration in the progression of TDP-43 in frontotemporal lobar degeneration | Yousef A, Robinson JL, Irwin DJ, Byrne MD, Kwong LK, Lee EB, Xu Y, Xie SX, Rennert L, Suh ER, Van Deerlin VM, Grossman M, Lee VM-Y, Trojanowski JQ | 2017 | Acta Neuropathologica Communications | Area Quantification, Cytonuclear | HALO | |
Qualitative Comparison Between Carrier-based and Classical Tissue Microarrays | Lisenko K, Leichsenring J, Zgorzelski C, Longuespee R, Casadonte R, Harms A, Kazdal D, Stenzinger A, Warth A, Kriegsmann M | 2017 | Applied Immunohistochemistry & Molecular Morpholgy | HALO | ||
In situ macrophage phenotypic transition is affected by altered cellular composition prior to acute sterile muscle injury | Patsalos A, Pap A, Varga T, Trencsenyi G, Contreras GA, Garai I, Papp Z, Dezso B, Pintye E, Nagy L | 2017 | The Journal of Physiology | Myology | HALO | |
Obstruction of BRAFV600E transcription by complementary PNA oligomers as a means to inhibit BRAF-mutant melanoma growth | Rothman JH, Surriga O, de Stanchina E, Vasudeva SD, Schwartz GK | 2017 | Cancer Gene Therapy | Oncology | HALO | |
The integrative clinical impact of tumor-infiltrating T lymphocytes and NK cells in relation to B lymphocyte and plasma cell density in esophageal and gastric adenocarcinoma | Svensson MC, Warfvinge CF, Fristedt R, Hedner C, Borg D, Eberhard J, Micke P, Nodin B, Leandersson K, Jirstrom K | 2017 | Oncotarget | Immuno-oncology | Object Colocalization | HALO |
Control of mitochondrial function and cell growth by the atypical cadherin Fat1 | Cao LL, Riascos-Bernal DF, Chinnasamy P, Dunaway CM, Hou R, Pujato MA, O'Rourke BP, Miskolci V, Guo L, Hodgson L, Fiser A, Sibinga NES | 2016 | Nature | Metabolism | Cytonuclear | HALO |
Phosphorylation of calcium/calmodulin-stimulated protein kinase II at T286 enhances invasion and migration of human breast cancer cells | Chi M, Evans, Gilchrist J, Mayhew J, Hoffman A, Pearsall EA, Jankowski H, Brzozowski JS, Skelding KA | 2016 | Scientific Reports | Oncology | Cytonuclear | HALO |
Evidence of ?-Cell Dedifferentiation in Human Type 2 Diabetes | Cinti F, Bouchi R, Kim-Muller JY, Ohmura Y, Sandoval PR, Masini M, Marselli L, Suleiman M, Ratner LE, Marchetti P, Accili D | 2016 | The Journal of Clinical Endocrinology & Metabolism | Metabolism | Cytonuclear | HALO |
Cutaneous wound healing through paradoxical MAPK activation by BRAF inhibitors | Escuin-Ordinas H, Li S, Xie MW, Sun L, Hugo W, Huang RR, Jiao J, Meira de-Faria F, Realegeno S, Krystofinski P, Azhdam A, Komenan SMD, Atefi M, Comin-Anduix B, Pellegrini M, Cochran AJ, Modlin RL, HerschmanHR, Lo RS, McBride WH, Segura T, Ribas A | 2016 | Nature Communications | Wound Healing | Cytonuclear | HALO |
A Phase II Trial of Dovitinib in BCD-Unresponsive Urothelial Carcinoma with FGFR3 Mutations or Over-Expression: Hoosier Cancer Research Network Trial HCRN 12-157 | Hahn NH, Bivalacqua TJ, Ross AE, Netto GJ, Baras AS, Park JC, Chapman C, Masterson TA, Koch MO, Bihrle R, Foster RS, Gardner TA, Cheng L, Jones DR, Kyle McElyea K, Sandusky GE, Breen T, Liu Z, Albany C, Moore ML, Loman RA, Reed A, Turner SA, de Abreu FB, Gallagher TL, Tsongalis GJ, Plimack ER, Greenberg RE, Geynisman DM | 2016 | Clinical Cancer Research | Oncology | Classifier, Cytonuclear | HALO |
Mitogen-activated Protein Kinase Kinase Activity Maintains Acinar-to-Ductal Metaplasia and Is Required for Organ Regeneration in Pancreatitis | Halbrook CJ, Wen H-J, Ruggeri JM, Takuchi KK, Zhang Y, di Magliano MP, Crawford HC | 2016 | Cellular and Molecular Gastroenterology and Hepatology | Immunology, Gastroenterology | Cytonuclear | HALO |
Fully automated RNAscope in situ hybridization assays for formalin?fixed paraffin?embedded cells and tissues | Anderson CM, Zhang B, Miller M, Butko E, Wu X, Laver T, Kernag C, Kim J, Luo Y, Lamparski H | 2016 | Journal of Cellular Biochemistry | Oncology, Gastroenterology, Infectious Disease | ISH/FISH | HALO |
A Depot Medroxyprogesterone Acetate Dose That Modes Human Use and Its Effect on Vaginal SHIV Acquisition Risk | Butler K, Ritter JM, Ellis S, Morris MR, Hanson DL, McNicholl JM, Kersh EN | 2016 | J Acquir Immune Defic Syndr | Infectious Disease | Layer Thickness | HALO |
Epigenetic regulation of the thioredoxin-interacting protein (TXNIP) gene by hyperglycemia in kidney | De Marinis Y, Cai M, Bompada P, Atac D, Kotova O, Johansson ME, Garcia-Vaz E, Gomez MF, Laakso M, Groop L | 2016 | Kidney International | Metabolism | Area Quantification | HALO |
ProNGF is a potential diagnostic biomarker for thyroid cancer | Faulkner S, Roselli S, Demont Y, Pundavela J, Choquet G, Leissner P, Oldmeadow C, Attia J, Walker MM, Hondermarck H | 2016 | Oncotarget | Oncology | Area Quantification | HALO |
The Dynamics and Turnover of Tau Aggregates in Cultured Cells: Insights into Therapies for Tauopathies | Guo JL, Buist A, Soares A, Callaerts K, Calafate S, Stevenaert F, Daniels JP, Zoll BE, Crowe A, Brunden KR, Moechars D, Lee VMY | 2016 | The Journal of Biological Chemistry | Neuroscience | Area Quantification | HALO |
Unique pathological tau conformers from Alzheimer's brains transmit tau pathology in nontransgenic mice | Guo JL, Narasimhan S, Changolkar L, He Z, Stieber Z, Zhang B, Gathagan RJ, Iba M, McBride JD, Trojanowski JQ, Lee VMY | 2016 | Journal of Experimental Medicine | Neuroscience | Area Quantification | HALO |
Bimodality of intratumor Ki67 expression is an independent prognostic factor of overall survival in patients with invasive breast carcinoma | Laurinavicius A, Plancoulaine B, Rasmusson A, Besusparis J, Augulis R, Meskauskas R, Herlin P, Laurinaviciene A, Muftah AAA, Miligy I, Aleskandarany M, Rakha EA, Green AR, Ellis IO | 2016 | Virchows Archiv | Oncology | Classifier, Cytonuclear | HALO |
Resistance to Anti-VEGF Therapy Mediated by Autocrine IL6/STAT3 Signaling and Overcome by IL6 Blockade | Eichten A, Su J, Adler AP, Zhang L, Ioffe E, Parveen AA, Yancopoulos GD, Rudge J, Lowy I, Lin HC, MacDonald D, Daly C, Duan X, Thurston G | 2016 | Cancer Research | Oncology, Immuno-oncology | Cytonuclear, Object Colocalization | HALO |
Cerebral Protection During MitraClip Implantation: Initial Experience at 2 Centers | Frerker C, Schlüter M, Sanchez OD, Reith S, Romero ME, Ladich E, Schröder J, Schmidt T, Kreidel F, Joner M | 2016 | JACC: Cardiovascular Interventions | Myology | Object Colocalization | HALO |
Upregulation of Glucose-Regulated Protein 78 in Metastatic Cancer Cells Is Necessary for Lung Metastasis Progression | Lizardo MM, Morrow JJ, Miller TE, Hong ES, Ren L, Mendoza A, Halsey CH, Scacheri PC, Helman LJ, Khanna C | 2016 | Neoplasia | Oncology | Cytonuclear | HALO |
Evaluation of the brain-penetrant microtubule-stabilizing agent, dictyostatin, in the PS19 tau transgenic mouse model of tauopathy | Makani V, Zhang B, Han H, Yao Y, Lassalas P, Lou K, Paterson I, Lee VMY, Trojanowski JQ, Ballatore C, Smith AB, Brunden KR | 2016 | Acta Neuropatholgica Communications | Neuroscience | Area Quantification | HALO |
CNS-accessible inhibitor of glucosylceramide synthase for substrate reduction therapy of neuronopathic Gaucher disease | Marshall J, Sun Y, Bangari DS, Budman E, Park H, Nietupski JB, Allaire A, Cromwell MA, Wang B, Grabowski GA, Leonard JP, Cheng SH | 2016 | Molecular Therapy | Neuroscience | Area Quantification | HALO |
Leptin, BMI, and a Metabolic Gene Expression Signature Associated with Clinical Outcome to VEGF Inhibition in Colorectal Cancer | Pommier AJC, Farren M, Patel B, Wappett M, Michopoulos F, Smith NR, Kendrew J, Frith J, Huby R, Eberlein C, Campbell H, Womack C, Smith PD, Robertson J, Morgan S, Critchlow SE, Barry ST | 2016 | Cell Metabolism | Oncology, Metabolism, Gastroenterology | Area Quantification | HALO |
Intrathecal Administration of AAV/GALC Vectors in 10- 11-Day-Old Twitcher Mice Improves Survival and Is Enhanced by Bone Marrow Transplant | Karmuthil-Melethil S, Marshall MS, Heindel C, Jakubauskas B, Bongarzone ER, Gray SJ | 2016 | Journal of Neuroscience Research | Neuroscience | Axon | HALO |
Tasquinimod modulates tumor-infiltrating myeloid cells and improves the antitumor immune response to PD-L1 blockade in bladder cancer | Nakhlé J, Pierron V, Bauchet A-L, Plas P, Thiongane A, Meyer-Losic F, Schmidlin F | 2016 | OncoImmunology | Oncology, Immuno-oncology | Cytonuclear | HALO |
Primary resistance to PD-1 blockade mediated by JAK1/2 mutations | Shin DS, Zaretsky JM, Escuin-Ordinas H, Garcia-Diaz A, Hu-Lieskovan S, Kalbasi A, Grasso CS, Hugo W, Sandoval S, Torrejon DY, Palaskas N, Rodriguez GA, Parisi G, Azhdam A, Chmielowski B, Cherry G, Seja E, Berent-Maoz B, Shintaku IP, Le DT, Pardol DM, Diaz LA, Tumeh PC, Graeber TG, Lo RS, Comin-Anduix B, Ribas A | 2016 | Cancer Discovery | Oncology, Immuno-oncology | Cytonuclear | HALO |
KS-Detect-Validation of Solar Thermal PCR for the Diagnosis of Kaposi's Sarcoma Using Pseudo-Biopsy Samples | Snodgrass R, Gardner A, Jiang L, Fu C, Cesarman E, Erickson D | 2016 | PLOS ONE | Oncology | Cytonuclear | HALO |
Development of antibody-siRNA conjugate targeted to cardiac and skeletal muscles | Sugo T, Terada M, Oikawa T, Miyata K, Nishimura S, Kenjo E, Ogasawara-Shimizu M, Makita Y, Imaichi S, Murata S, Kentaro Otaka, Kikuchi K, Teratani M, Masuda Y, Kamei T, Takagahara S, Ikeda S, Ohtaki T, Matsumoto H | 2016 | The Journal of Controlled Release | Myology | Cytonuclear, Muscle Fiber | HALO |
Use of the Fluidigm C1 platform for RNA sequencing of single mouse pancreatic islet cells | Xin Y, Kim J, Ni M, Wei Y, Okamoto H, Lee J, Adler C, Cavino K, Murphy AJ, Yancopoulos GD, Lin HC, Gromada J | 2016 | Proceedings of the National Academy of Sciences | Metabolism | Cytonuclear | HALO |
Comparison of the methods for measuring the Ki-67 labeling index in adrenocortical carcinoma: manual versus digital image analysis | Yamazaki Y, Nakamura Y, Shibahara Y, Konosu-Fukaya S, Sato N, Kubota-Nakayama F, Oki Y, Baba S, Midorikawa S, Morimoto R, Satoh F, Sasano | 2016 | Human Pathology | Oncology | Cytonuclear | HALO |
Variability in Platelet-Derived Growth Factor Receptor Alpha Antibody Specificity May Impact Clinical Utility of Immunohistochemistry Assays | Holzer TR, Reising LO, Credille KM, Schade AE, Oakley | 2016 | Journal of Histochemistry & Cytochemistry | Oncology | Cytonuclear, ISH/FISH | HALO |
Differential Cytokine Gene Expression in Granulomas from Lungs and Lymph Nodes of Cattle Experimentally Infected with Aerosolized Mycobacterium bovis | Palmer MV, Thacker TC, Waters WR | 2016 | PLOS One | Infectious Disease | ISH/FISH | HALO |
RNA Sequencing of Single Human Islet Cells Reveals Type 2 Diabetes Genes | Xin Y, Kim J, Okamoto H, Ni M, Wei Y, Adler C, Murphy AJ, Yancopoulos GD, Lin C, Gromada J | 2016 | Endocrinology | Metabolism | Islet | HALO |
The Prognostic Impact of NK/NKT Cell Density in Periampullary Adenocarcinoma Differs by Morphological Type and Adjuvant Treatment | Lundgren S, Warfvinge CF, Elebro J, Heby M, Nodin B, Krzyzanowska A, Bjartell A, Leandersson K, Eberhard J, Jirstrom K | 2016 | PLOS ONE | Oncology, Immuno-oncology | Object Colocalization | HALO |
Solid-state NMR structure of a pathogenic fibril of full-length human [alpha]-synuclein | Tuttle MD, Comellas G, Nieuwkoop AJ, Covell DJ, Berthold DA, Kloepper KD, Courtney JM, Kim JK, Barclay AM, Kendall A, Wan W, Stubbs G, Schwieters CD, Lee VMY, George JM, Rienstra CM | 2016 | Structural & Molecular Biology | Neuroscience | Area Quantification | HALO |
RNA Sequencing of Single Human Islet Cells Reveals Type 2 Diabetes Genes | Xin Y, Kim J, Okamoto H, Ni M, Wei Y, Adler C, Murphy AJ, Yancopoulos GD, Lin C, Gromada J | 2016 | Cell Metabolism | Metabolism | ISH/FISH | HALO |
Synergistic targeted inhibition of MEK and dual PI3K/mTOR diminishes viability and inhibits tumor growth of canine melanoma underscoring its utility as a preclinical model for human mucosal melanoma | Wei B-R, Michael HT, Hasley CHC, Peer CJ, Adhikari A, Dwyer JE, Hoover SB, El Meskini R, Kozlov S, Ohler ZW, Figg WD, Merlino G, Simpson RM | 2016 | Pigment Cell & Melanoma Research | Oncology | Area Quantification | HALO |
Mutations Associated with Acquired Resistance to PD-1 Blockade in Melanoma | Zaretsky JM, Garcia-Diaz A, Shin DS, Escuin-Ordinas H, Hugo W, Hu-Lieskovan S, Torrejon DY, Abril-Rodriguez G, Sandoval S, Barthly L, Saco J, Homet Moreno BH, Mezzadra R, Chmielowski B, Ruchalski K, Shintaku IP, Sanchez PJ, Puig-Saus C, Cherry G, Seja E, Kong X, Pang J, Berent-Maoz B, Comin-Anduix B, Graeber TG, Tumeh PC, Schumacher TNM, Lo RS, Ribas A | 2016 | The New England Journal of Medicine | Oncology, Immuno-oncology | Cytonuclear | HALO |
The PDE10A inhibitor MP-10 and haloperidol produce distinct gene expression profiles in the striatum and influence cataleptic behavior in rodents | Gentzel RC, Toolan D, Roberts R, Koser AJ, Kandebo M, Hershey J, Renger JJ, Uslaner J, Smith SM | 2015 | Neuropharmacology | Neuroscience | Cytonuclear | HALO |
Phenotyping of tumor-associated macrophages in colorectal cancer: impact on single cell invasion (tumor budding) and clinicopathological outcome | Koelzer VH, Canonica K, Dawson H, Sokol L, Karamitopoulou-Diamantis E, Lugli A, Zlobec I | 2015 | OncoImmunology | Oncology, Immuno-oncology, Gastroenterology | Cytonuclear | HALO |
G-protein-independent coupling of MC4R to Kir7. 1 in hypothalamic neurons | Ghamari-Langroudi M, Digby GJ, Sebag JA, Millhauser GL, Palomino R, Matthews R, Gillyard T, Panaro BL, Tough IR, Cox HM, Denton JS, Cone RD | 2015 | Nature | Metabolism | ISH/FISH | HALO |
Analysis of putative mucosal SHIV susceptibility factors during repeated DMPA treatments in pigtail macaques | Butler K, Ritter J, Ellis S, Henning TR, Montague J, Zaki S, Garber, McNicholl JM, Kersh EN | 2015 | Journal of medical primatology | Infectious Disease | Layer Thickness | HALO |
Semi-Automated Digital Image Analysis of Pick's Disease and TDP-3 Proteinopathy | Irwin DJ, Byrne MD, McMillan CT, Cooper F, Arnold SE, Lee EB, Van Deerlin VM, Xie SX, Lee VM, Grossman M, Trojanowski JQ | 2015 | Journal of Histochemistry & Cytochemistry | Neuroscience | Object Colocalization, Layer Thickness | HALO |
Myostatin blockade with a fully human monoclonal antibody induces muscle hypertrophy and reverses muscle atrophy in young and aged mice | Latres E, Pangilinan J, Miloscio L, Bauerlein R, Na E, Potocky TB, Huang Y, Eckersdorff M, Rafique A, Mastaitis J, Lin C, Murphy AJ, Yancopoulos GD, Gromada J, Stitt T | 2015 | Skeletal Muscle | Myology | Muscle Fiber | HALO |
Relationship of Estimated SHIV Acquisition Time Points During the Menstrual Cycle and Thinning of Vaginal Epithelial Layers in Pigtail Macaques | Kersh EN, Ritter J, Butler K, Ostergaard SD, Hanson D, Ellis S, Zaki S, McNicholl JM | 2015 | Sexually Transmitted Diseases | Infectious Disease | Layer Thickness | HALO |
Glucagon Receptor Blockade With a Human Antibody Normalizes Blood Glucose in Diabetic Mice and Monkeys | Okamoto H, Cavino K, Na E, Krumm E, Kim SY, Cheng X, Murphy AJ, Yancopoulos GD, Gromada J | 2015 | Endocrinology | Metabolism | Area Quantification | HALO |
Nerve fibers infiltrate the tumor microenvironment and are associated with nerve growth factor production and lymph node invasion in breast cancer | Pundavela J, Roselli S, Faulkner S, Attia J, Scott RJ, Thorne RF, Forbes JF, Bradshaw RA, Walker MM, Jobling P, Hondermarck H | 2015 | Molecular Oncology | Oncology, Neuroscience | Area Quantification | HALO |
Tasquinimod triggers an early change in the polarization of tumor associated macrophages in the tumor microenvironment | Olsson A, Nakhle J, Sundstedt A, Plas P, Bauchet AL, Pierron V, Bruetschy L, Deronic A, Tomgren M, Liberg D, Schmidlin F, Leanderson T | 2015 | Journal for ImmunoTherapy of Cancer | Oncology, Immuno-oncology | Cytonuclear | HALO |
Exacerbated experimental colitis in TNFAIP8-deficient mice | Sun H, Lou Y, Porturas T, Morrissey S, Luo G, Qi J, Ruan Q, Shi S, Chen YH | 2015 | The Journal of Immunology | Gastroenterology | Cytonuclear | HALO |
Combination therapy reverses hyperglycemia in NOD mice with established type 1 diabetes | Xue S, Posgai A, Wasserfall C, Myhr C, Campbell-Thompson M, Mathews CE, Brusko T, Rabinovitch A, Savinov A, Battaglia M, Schatz D, Haller M, Atkinson MA | 2015 | Diabetes | Metabolism | Cytonuclear | HALO |
A combined oral contraceptive affects mucosal SHIV susceptibility factors in a pigtail macaque (Macaca nemestrina) model | Ostergaard DS, Butler K, Ritter JM, Johnson R, Sanders J, Powell N, Lathrop G, Zaki SR, McNicholl JM, Kersh EN | 2015 | Journal of medical primatology | Infectious Disease | Layer Thickness | HALO |
Applicability of digital analysis and imaging technology in neuropathology assessment | Dunn WD, Gearing M, Park Y, Zhang L, Hanfelt J, Glass JD, Gutman DA | 2015 | Neuropathology | HALO | ||
Islet-1 is essential for pancreatic ?-cell function | Ediger BN, Du A, Liu J, Hunter CS, Walp ER, Schug J, Kaestner KH, Stein R, Stoffers DA, May CL | 2014 | Diabetes | Metabolism | Cytonuclear | HALO |
Characterization of the exocrine pancreas in the male Zucker diabetic fatty rat model of type 2 diabetes mellitus following 3 months of treatment with sitagliptin | Forest T, Holder D, Smith A, Cunningham C, Yao X, Dey M, Frederick C, Prahalada S | 2014 | Endocrinology | Metabolism | Cytonuclear | HALO |
Peripheral androgen receptor gene suppression rescues disease in mouse models of spinal and bulbar muscular atrophy | Lieberman AP, Yu Z, Murray S, Peralta R, Low A, Guo S, Yu XX, Cortes CJ, Bennett CF, Monia BP, La Spada AR, Hung G | 2014 | Cell Reports | Myology | Muscle Fiber | HALO |
ANGPTL8/betatrophin does not control pancreatic beta cell expansion | Gusarova V, Alexa CA, Na E, Stevis PE, Xin Y, Bonner-Weir S, Cohen JC, Hobbs HH, Murphy AJ, Yancopoulos GD, Gromada J | 2014 | Cell | Metabolism | Area Quantification | HALO |
PD-1 blockade induces responses by inhibiting adaptive immune resistance | Tumeh PC, Harview CL, Yearley JH, Shintaku IP, Taylor EJM, Robert L, Chmielowski B, Spasic M, Henry G, Ciobanu V, West AN, Carmona M, Kivork C, Seja E, Cherry G, Gutierrez A, Grogan TR, Mateus C, Tomasic G, Glaspy JA, Emerson RO, Robins H, Pierce RH, Elas | 2014 | Nature | Oncology, Immuno-oncology | Cytonuclear | HALO |
Marked expansion of exocrine and endocrine pancreas with incretin therapy in humans with increased exocrine pancreas dysplasia and potential for glucagon-producing neuroendocrine tumors | Butler AE, Campbell-Thompson M, Gurlo T, Dawson DW, Atkinson M, Butler PC | 2013 | Diabetes | Oncology, Metabolism | Cytonuclear | HALO |
CRISPR-Cas9 gene editing of hepatitis B virusin chronically infected humanized mice | Stone D, Long KR, Loprieno MA, De Silva Feelixge HS, Kenkel EJ, Liley, RM, Rapp S, Roychoudhury P, Nguyen T, Stensland L, Cólon-Thillet R, Klouser LM, Weber ND, Le C, Wagoner J, Goecker EA, Li AZ, Eichholz K, Corey L, Tyrrell DL, Greninger AL, Huang ML, Polyak SJ, Aubert M, Sagartz JE, Jerome KR | 2021 | Molecular Therapy Methods & Clinical Development | Infectious Disease | HALO Link | |
Digital Immunophenotyping Predicts Disease Free and Overall Survival in Early Stage Melanoma Patients | De Logu F, Galli F, Nassini R, Ugolini F, Simi S, Cossa M, Miracco C, Gianatti A, De Giorgi V, Rulli E, Cossu A, Massi D, Mandalà M | 2021 | Cells | Oncology, Immuno-oncology | Multiplex IHC | HALO, HALO Link |
Monomeric/dimeric forms of Fgf15/FGF19 show differential activity in hepatocyte proliferation and metabolic function | Williams CM, Calderon JH, Hock E, Jimenez Y, Barringer K, Carbonaro M, Molina-Portela MP, Thurston G, Li Z, Daly C | 2021 | The FASEB Journal | Metabolism | Cytonuclear | HALO, HALO Link |
CD38 in Advanced Prostate Cancers | Guo C, Crespo M, Gurel B, Dolling D, Rekowski J, Sharp A, Petremolo A, Sumanasuriya S, Rodrigues DN, Ferreira A, Pereira R, Figueiredo I, Mehra N, Lambros MBK, Neeb A, Gil V, Seed G, Terstappen L, Alimonti A, Drake CG, Yuan W, de Bono JS | 2021 | European Urology | Oncology | Classifier, Highplex FL | HALO |
Exploring transcriptional regulators Ref-1 and STAT3 as therapeutic targets in malignant peripheral nerve sheath tumours | Gampala S, Shah F, Zhang C, Rhodes SD, Babb O, Grimard M, Wireman RS, Rad E, Calver B, Bai R-Y, Staedtke V, Hulsey EL, Saadatzadeh MR, Pollok KE, Tong Y, Smith AE, Clapp DW, Tee AR, Kelley MR, Fishel ML | 2021 | British Journal of Cancer | Oncology | Area Quantification, Cytonuclear | HALO |
First in class dual MDM2/MDMX inhibitor ALRN-6924 enhances antitumor efficacy of chemotherapy in TP53 wild-type hormone receptor-positive breast cancer models | Pairawan S, Zhao M, Yuca E, Annis A, Evans K, Sutton D, Carvajal L, Ren J-G, Santiago S, Guerlavais, Akcakanat A, Tapia C, Yang F, Bose PSC, Zheng X, Dumbrava EI, Aivado M, Meric-Bernstam F | 2021 | Breast Cancer Research | Oncology | Cytonuclear | HALO |
Influence of tumor-infiltrating immune cells on local control rate, distant metastasis, and survival in patients with soft tissue sarcoma | Smolle MA, Herbsthofer L, Goda M, Granegger B, Brcic I, Bergovec M, Scheipl S, Prietl B, El-Heliebi A, Pichler M, Gerger A, Posch F, Tomberger M, López-García P, Feichtinger J, Baumgartner C, Leithner A, Liegl-Atzwanger B, Szkandera J | 2021 | OncoImmunology | Immuno-oncology | Highplex FL | HALO |
Phenotypic characterization of Adig null mice suggests roles for adipogenin in the regulation of fat mass accrual and leptin secretion | Alvarez-Guaita A, Patel S, Lim K, Haider A, Dong L, Conway OJ, Ma MKL, Chiarugi D, Saudek V, O'Rahilly S, Savage DB | 2021 | Cell Reports | Metabolism | Vacuole | HALO |
Prognostic Impact of CXCR7 and CXCL12 Expression in Patients with Esophageal Adenocarcinoma | Goto M, Shibahara Y, Baciu C, Allison F, Yeung JC, Darling GE, Liu M | 2021 | Thoracic Oncology | Oncology | HALO | |
An extended release GLP-1 analogue increases ?-synuclein accumulation in a mouse model of prodromal Parkinson's disease | Bergkvist L, Johnson ME, Mercado G, Steiner JA, Meyerdick L, Schulz E, Madaj Z, Ma J, Becker K, Li Y, Brudin P | 2021 | Experimental Neurology | Neuroscience | Area Quantification | HALO |
Activation of the renal GLP?1R leads to expression of Ren1 in the renal vascular tree | Bjørnholm KD, Ougaard ME, Skovsted GF, Knudsen LB, Pyke C | 2021 | Endocrinology, Diabetes, & Metabolism | Metabolism | ISH/FISH | HALO |
A Method to Pre-Screen Rat Mammary Gland Whole-Mounts Prior To RNAscope | Duderstadt EL, Sanders MA, Samuelson DJ | 2021 | Journal of Mammary Gland Biology and Neoplasia | ISH/FISH | HALO | |
Activated Regulatory T-Cells, Dysfunctional and SenescentT-Cells Hinder the Immunity in Pancreatic Cancer | Sivakumar S, Abu-Shah E, Ahern DJ, Arbe-Barnes EH, Jainarayanan AK, Mangal N, Reddy S, Rendek A, Easton A, Kurz E, Silva M, Soonawalla Z, Heij LR, Bashford-Rogers R, Middleton MR, DUstin ML | 2021 | cancers | Classifier, Multiplex IHC, Spatial Analysis, Highplex FL | HALO | |
Age-associated expression of p21and p53 during human wound healing | Chia CW, Sherman-Baust CA, Larson SA, Pandey R, Withers R, Karikkineth AC, Zukley LM, Campisi J, Egan JM, Sen R, Ferrucci L | 2021 | Aging Cell | Dermatology | Area Quantification, ISH/FISH, Multiplex IHC | HALO |
Breast adipocyte size associates with ipsilateral invasive breast cancer risk after ductal carcinoma in situ | Almekinders MMM, Schaapveld M, Thijssen B, Visser LL, Bismeijer T, Sanders J, Isnaldi E, Hofland I, Mertz M, Wessels LFA, Broeks A, Hooijberg E, Zwart W, Lips EH, Grand Challenge PRECISION Consortium, Desmedt C, Wesseling J | 2021 | npj Breast Cancer | Oncology | Vacuole | HALO |
COM902, a novel therapeutic antibody targeting TIGIT augments anti-tumor T cell function in combination with PVRIG or PD-1 pathway blockade | Kyle Hansen K, Sandeep Kumar, Kathryn Logronio, Sarah Whelan, Samir Qurashi, Hsin-Yuan Cheng, Andrew Drake, Margaret Tang, Patrick Wall, David Bernados, Ling Leung, Eran Ophir, Zoya Alteber Z, Gady Cojocaru G, Moran Galperin M, Masha Frenkel M, Mark White M, John Hunter J, Spencer C. Liang & Maya F. Kotturi | 2021 | Cancer Immunology, Immunotherapy | Immuno-oncology | HALO | |
Conventional and semi-automatic histopathological analysis of tumor cell content for multigene sequencing of lung adenocarcinoma | Kazdal D, Rempel E, Oliveira C, Allgäuer M, Harms A, Singer K, Kohlwes E, Ormanns S, Fink L, Kriegsmann J, Leichsenring M, Kriegsmann K, Stögbauer F, Tavernar L, Leichsenring J, Volckmar A-L, Longuespée R, Winter H, Eichhorn M, Heußel CP, Herth F, Christopoulos P, Reck M, Muley T, Weichert W, Budczies J, Thomas M, Peters S, Warth A, Schirmacher P, Stenzinger A, Kriegsmann M | 2021 | Translational Lung Cancer Research | Oncology | Classifier, Cytonuclear | HALO |
Crotonaldehyde exposure induces liver dysfunction and mitochondrial energy metabolism disorder in rats | Zhang S, Zhang B, Zhang Q, Zhang Z | 2021 | Toxicology Mechanisms and Methods | Metabolism | HALO | |
Cytotoxic lymphocytes target characteristic biophysical vulnerabilities in cancer | Bhanot U, MOrris L, Boire A, Hsu KC, Massague J, Huse M, Er EE | 2021 | Immunity | Immuno-oncology | HALO | |
Empagliflozin Disrupts a Tnfrsf12a-Mediated Feed Forward Loop That Promotes Left Ventricular Hypertrophy | Yerra VG, Batchu SN, Kabir G, Advani SL, Liu Y, Siddiqi FS, Connelly KA, Advani A | 2021 | Cardiovascular Drugs and Therapy | Myology | HALO | |
Genetic Inactivation of Peroxiredoxin-I Impairs the Growth of Human Pancreatic Cancer Cells | Dahou H, Minati M-A, Jacquemin P, Assi M | 2021 | antioxidants | Oncology | Cytonuclear | HALO |
Immune-regulated IDO1-dependent tryptophan metabolism is source of one-carbon units for pancreatic cancer and stellate cells | Newman AC, Falcone M, Uribe AH, Zhang T, Athineos D, Pietzke M, Vazquez A, Blyth K, Maddocks ODK | 2021 | Molecular Cell | Immuno-oncology | Classifier, ISH/FISH | HALO |
Inhibition of STAT3 augments antitumor efficacy of anti-CTLA-4 treatment against prostate cancer | Witt K, Evans-Axelsson S, Lundqvist A, Johansson M, Bjartell A, Hellsten R | 2021 | Cancer Immunology, Immunotherapy | Immuno-oncology | Area Quantification, Multiplex IHC | HALO |
The immune suppressive microenvironment affects efficacy of radio-immunotherapy in brain metastasis | Niesel K, Schulz M, Anthes J, Alekseeva T, Macas J, Salamero-Boix A, Mockl A, Oberwahrenbrock T, Lolies M, Stein S, Plate KH, Reiss Y, Rodel F, Sevenich L | 2021 | EMBO Molecular Medicine | Immuno-oncology | Spatial Analysis, Highplex FL | HALO |
Tracing Lung Cancer Risk Factors Through Mutational Signatures in Never-Smokers | Landi MT, Synnott NC, Rosenbaum J, Zhang T, Zhu B, Shi J, Zhao W, Kebede M, Sang J, Choi J, Mendoza L, Pacheco M, Hicks B, Caporaso NE, Abubakar M, Gordenin DA, Wedge, Alexandrov LB, Rothman N, Lan Q, Garcia-Closas M, Chanock SJ | 2021 | American Journal of Epidemiology | Oncology | HALO | |
Tumor cell PD-L1 expression is a strong predictor of unfavorable prognosis in immune checkpoint therapy-naive clear cell renal cell cancer | Möller K, Fraune C, Blessin NC, Lennartz M, Kluth M, Hube-Magg C, Lindhorst L, Dahlem R, Fisch M, Eichenauer T, Riechardt S, Simon R, Sauter G, Büscheck F, Höppner W, Matthies C, Doh O, Krech T, Marx AH, Zecha H, Rink M, Steurer S, Clauditz TS | 2021 | International Urology and Nephrology | Immuno-oncology | Multiplex IHC, TMA | HALO |
Validation of multiplex immunofluorescence and digital image analysis for programmed death-ligand 1 expression and immune cell assessment in non-small cell lung cancer: comparison with conventional immunohistochemistry | Wu J, Mao L, Sun W, Yang X, Wang H, Liu X, Chi K, Xiaozheng H, Lin D | 2021 | Journal of Clinical Pathology | Immuno-oncology | HALO | |
VGLUT2 is a determinant of dopamine neuron resilience in a rotenone model of dopamine neurodegeneration | Buck SA, De Miranda BR, Logan RW, Fish KN, Greenamyre JT, Freyberg Z | 2021 | The Journal of Neuroscience | Neuroscience | ISH/FISH | HALO |
Ki-67 Proliferation Index Assessment in Gastroenteropancreatic Neuroendocrine Tumors by Digital Image Analysis With Stringent Case and Hotspot Level Concordance Requirements | Boukhar SA, Gosse MD, Bellizzi AM, Rajan A | 2021 | American Journal of Clinical Pathology | Oncology | HALO | |
Global Neurotoxicity: Quantitative Analysis of Rat Brain Toxicity Following Exposure to Trimethyltin | Srivastava A, Liachenko S, Sarkar S, Paule M, Sadovova N, Hanig JP | 2021 | International Journal of Toxicology | Toxicology | HALO | |
High estrogen receptor alpha activation confers resistance to estrogen deprivation and is required for therapeutic response to estrogen in breast cancer | Traphagen NA, Hosford SR, Jiang A, Marotti JD, Brauer BL, Demidenko E, Miller TW | 2021 | Oncogene | Oncology | HALO | |
In vivo endothelialization and neointimal hyperplasia assessment after rabbit carotid endarterectomy with bovine pericardium | Chen Y, Feng Y, Wang T, Zhang X, Zhang M, Bai X, Li L, Yang K, Ma Y, Zhang Z, Jiao L | 2021 | Annals of Translational Medicine | Myology | Cytonuclear | HALO |
Prognostic role of proliferating CD8+ cytotoxic Tcells in human cancers | Blessin NC, Li W, Mandelkow T, Jansen HL, Yang C, Raedler JB, Simon R, Büscheck F, Dum D, Luebke AM, Hinsch A, Möller K, Menz A, Bernreuther C, Lebok P, Clauditz T, Sauter G, Marx A, Uhlig R, Wilczak W, Minner S, Krech T, Fraune C, Höflmayer D, Burandt E, Steurer S | 2021 | Cellular Oncology | Immuno-oncology | Highplex FL, TMA | HALO |
TNFα secreted by glioma associated macrophages promotes endothelial activation and resistance against anti-angiogenic therapy | Wei Z, Singh O, Ekinci C, Gill J, Li M, Mamatjan Y, Karimi S, Bunda S, Mansouri S, Aldape K, Zadeh G | 2021 | Acta Neuropathologica Communications | Immunology, Neuroscience | Classifier, Multiplex IHC | HALO |
Tumor morphology and location associate with immune cell composition in pleomorphic sarcoma | Wustrack RL, Shao E, Sheridan J, Zimel M, Cho S-J, Horvai AE, Luong D, Kwek SS, Fong L, Okimoto RA | 2021 | Cancer Immunology, Immunotherapy | Immuno-oncology | Cytonuclear | HALO |
Engineered red blood cells as an off-the-shelf allogeneic anti-tumor therapeutic | Zhang X, Lou M, Dastagir SR, Nixon M, Khamhoung A, Schmidt A, Lee A, Subbiah N, McLaughlin DC, Moore CL, Gribble M, Bayhi N, Amin V, Pepi R, Pawar S, Lyford TJ, Soman V, Mellen J, Carpenter CL, Turka LA, Wickham Tj, Chen TF | 2021 | Nature Communications | Oncology | Object Colocalization, Highplex FL | HALO |
Mastocytosis-derived extracellular vesicles deliver miR-23a and miR-30a into pre-osteoblasts and prevent osteoblastogenesis and bone formation | Kim D-K, Bandara G, Cho Y-E, Komarow HD, Donahue DR, Karim B, Baek M-C, Kim HM, Metcalfe DD, Olivera A | 2021 | Nature Communications | Classifier | HALO | |
Mitigation of endemic GI-tract pathogen-mediated inflammation through development of multimodal treatment regimen and its impact on SIV acquisition in rhesus macaques | Bochart RM, Busman-Sahay K, Bondoc S, Morrow DW, Ortiz AM, Fennessey CM, Fischer MB, Shiel O, Swanson T, Shriver-Munsch CM, Crang HB, Armantrout KM, Barber-Axthelm AM, Langner C, Moats CR, Labriola CS, MacAllister R, Axthelm MK, Brenchley JM, Keele BF, Estes JD, Hansen SG, Smedley JV | 2021 | PLOS Pathogens | Infectious Disease | ISH/FISH, Multiplex IHC | HALO |
Mucosal IFNγ production and potential role in protection in Escherichia coli O157:H7 vaccinated and challenged cattle | Schaut RG, Palmer MV, Boggiatto PM, Kudva IT, Loving CL, Sharma VK | 2021 | Scientific Reports | Immunology | ISH/FISH | HALO |
Next-Generation Digital Histopathology of the Tumor Microenvironment | Mungenast F, Fernando A, Nica R, Boghiu B, Lungu B, Batra J, Ecker RC | 2021 | genes | Review | HALO | |
RIPK1 activation mediates neuroinflammation and disease progression in multiple sclerosis | Zelic M, Pontarelli F, Woodworth L, Zhu C, Mahan A, Ren Y, LaMorte M, Gruber R, Keane A, Loring P, Guo L, Xia T, Zhang B, Orning P, Lien E, Degterev A, Hammond T, Ofengeim D | 2021 | Cell Reports | Immunology | HALO | |
Single-cell dissection of cellular components and interactions shaping the tumor immune phenotypes in ovarian cancer | Hornburg M, Desbois M, Lu S, Guan Y, Lo AA, Kaufman S, Elrod A, Lotstein A, DesRochers TM, Munoz-Rodriguez JL, Wang X, Giltnane J, Mayba O, Turley SJ, Bourgon R, Daemen A, Wang Y | 2021 | Cancer Cell | Immuno-oncology | HALO | |
Acute inflammatory profiles differ with sex and age after spinal cord injury | Stewart AN, Lowe JL, Glaser EP, Mott CA, Shahidehpour RK, McFarlane KE, Bailey WM, Zhang B, Gensel JC | 2021 | Journal of Neuroinflammation | Immunology, Neuroscience | HALO | |
Analysis of genomic and non-genomic signaling of estrogen receptor in PDX models of breast cancer treated with a combination of the PI3K inhibitor alpelisib (BYL719) and fulvestrant | Jacquemetton J, Kassem L, Poulard C, Dahmani A, De Plater L, Montaudon E, Sourd L, Morisset L, El Botty R, Chateau-Joubert S, Vacher S, Bièche I, Treilleux I, Trédan O, Marangoni E, Le Romancer M | 2021 | Breast Cancer Research | Oncology | Multiplex IHC | HALO |
AP-3-dependent targeting of flippase ATP8A1 to lamellar bodies suppresses activation of YAP in alveolar epithelial type 2 cells | Kook S, Wang P, Meng S, Jetter CS, Sucre JMS, Benjamin JT, Gokey JJ, Hanby HA, Jaume A, Goetzl L, Marks MS, Guttentag SH | 2021 | Proceedings of the National Academy of Sciences | Fibrosis | HALO | |
Cellular Senescence in Human Aldosterone-Producing Adrenocortical Cells and Related Disorders | Pieroni J, Yamazaki Y, Gao X, Tezuka Y, Ogata H, Omata K, Ono Y, Morimoto R, Nakamura Y, Satoh F, Sasano H | 2021 | Biomedicines | Metabolism | Cytonuclear | HALO |
Functionally distinct POMC-expressing neuron subpopulations in hypothalamus revealed by intersectional targeting | Biglari N, Gaziano I, Schumacher J, Radermacher J, Paeger L, Klemm P, Chen W, Corneliussen S, Wunderlich CM, Sue M, Vollmar S, Klöckener T, Sotelo-Hitschfeld T, Abbasloo A, Edenhofer F, Reimann F, Gribble FM, Fenselau H, Kloppenburg P, Wunderlich FT, Brüning JC | 2021 | Nature Neuroscience | Neuroscience | ISH/FISH | HALO |
SeqStain is an efficient method for multiplexed, spatialomic profiling of human and murine tissues | Rajagopalan A, Venkatesh I, Aslam R, Kirchenbuechler D, Khanna S, Cimbaluk D, Kordower JH, Gupta V | 2021 | Cell Reports Methods | HALO | ||
Novel insulin sensitizer MSDC-0602K improves insulinemia and fatty liver disease in mice, alone and in combination with liraglutide | Kamm DR, Pyles KD, Sharpe MC, Healy LN, Colca JR, McCommis KS | 2021 | Journal of Biological Chemistry | Metabolism | HALO | |
Pathways of immune exclusion in metastatic osteosarcoma are associated with inferior patient outcomes | Ligon JA, Choi W, Cojocaru G, Fu W, Hsiue EH-C, Oke TF, Siegel N, Fong MH, Ladle B, Pratilas CA, Morris CD, Levin A, Rhee DS, Meyer CF, Tam AJ, Blosser R, Thompson ED, Suru A, McConkey D, Housseau F, Anders R, Pardoll DM, Llosa N | 2021 | Journal for ImmunoTherapy of Cancer | Immuno-oncology | Multiplex IHC | HALO |
Predicting nodal metastases in papillary thyroid carcinoma using artificial intelligence | Esce AR, Redemann JP, Sanchez AC, Olson GT, Hanson JA, Argwal S, Boyd NH, Martin DR | 2021 | The American Journal of Surgery | Oncology | HALO | |
Toluidine blue staining of murine mast cells and quantitation by a novel, automated image analysis method using whole slide skin images | Raja N, Naikodi S, Govindarajan A, Palanisamy K | 2021 | Journal of Histotechnology | Immunology | Cytonuclear | HALO |
Pancreatic ? cellselective zinc transporter 8 insufficiency accelerates diabetes associated with islet amyloidosis | Xu J, Wijesekara N, Regeenes R, Al Rijjal D, Piro AL, Song Y, Anne Wu A, Bhattacharjee A, Liu Y, Marzban L, Rocheleau JV, Fraser PE, Dai FF, Hu C, Wheeler MB | 2021 | JCI Insight | Metabolism | HALO | |
Human Type II Taste Cells Express ACE2 and are Infected by SARS-CoV-2 | Doyle M, Ashley Appleton A, Q Liu, Yao Q, Mazucanti C, Egan J | 2021 | American Journal of Pathology | Cytonuclear | HALO | |
Oncogenic BRAF, unrestrained by TGF?-receptor signalling, drives right-sided colonic tumorigenesis | Leach J, Vlahov N, Tsantoulis P, et al | 2021 | Nature Communications | Oncology | ISH/FISH, Highplex FL | HALO |
Attenuating CD3 affinity in a PSMAxCD3 bispecific antibody enables killing of prostate tumor cells with reduced cytokine release | Dang K, Castello G, Clarke S, et al. | 2021 | Journal for Immunotherapy of Cancer | Immuno-oncology | Multiplex IHC | HALO |
Heterogeneity in tertiary lymphoid structure B-cells correlates with patient survival in metastatic melanom | Lynch K, Young S, Menaveau M, et al. | 2021 | Journal for Immunotherapy of Cancer | Immuno-oncology | Highplex FL | HALO |
mRNA translation is a therapeutic vulnerability necessary for bladder epithelial transformation | Jana S, Deo R, Hough R, et al. | 2021 | JCI Insight | Oncology | Multiplex IHC, Highplex FL | HALO |
Approaches for Handling Immunopathological and Clinical Data Using Deep Learning Methodology: Multiplex IHC/IF Data as a Paradigm | Goh S, Chua Y, Lee J, Yeong J, Cai Y | 2021 | Histopathology and Liquid Biopsy | Review | HALO | |
Tumor necroptosis is correlated with a favorable immune cell signature and programmed death-ligand 1 expression in cholangiocarcinoma | Lomphithak T, Akara-amornthum P, Murakami K, et al. | 2021 | Scientific Reports | Immuno-oncology | Highplex FL | HALO |
Multiparametric Analyses of Hepatocellular Carcinoma Somatic Mouse Models and Their Associated Tumor Microenvironment | Taranto D, Ramirez C, Vegna S, et al. | 2021 | Current Protocols | Oncology | Multiplex IHC | HALO |
Quantification of Human Epidermal Growth Factor Receptor 2 by Immunopeptide Enrichment and Targeted Mass Spectrometry in Formalin-Fixed Paraffin-Embedded and Frozen Breast Cancer Tissues | Kennedy J, Whiteaker J, Kennedy L, Bosch D, Lerch M, Schoenherr R, Zhao L, Lin C, Chowdhury S, Kilgore M, Allison K, Wang P, Hoofnagle A, Baird G, Paulovich A | 2021 | Clinical Chemistry | Oncology | Classifier | HALO |
Pathological Change and Whole Transcriptome Alternation Caused by ePTFE Implantation in Myocardium | Shan Y, Zhang W, Chen G, Shi Q, Mi Y, Zhang H, Jia B | 2021 | BioMed Research International | Fibrosis | Area Quantification | HALO |
Detection of Lung Cancer from Whole-Slide Histopathologic Images Using Deep Learning Approach | Mishra N, Behera P, Nanda R, Sahoo M | 2019 | International Journal of Research in Engineering and Sciences | Oncology | Classifier | HALO AI |
Q134R: Small chemical compound with NFAT inhibitory properties improves behavioral performance and synapse function in mouse models of amyloid pathology | Sompol P, Gollihue J, Kraner S, Artiushin I, Cloyd R, Chishti E, Koren S, Nation G, Abisambra J, Huzian O, Nagy L, Santha M, Hackler L, Puskas L, Norris C | 2021 | Aging Cell | Neuroscience | Area Quantification | HALO |
Methods to Determine and Analyze the Cellular Spatial Distribution Extracted From Multiplex Immunofluorescence Data to Understand the Tumor Microenvironment | Parra E | 2021 | Frontiers in Molecular Biosciences | Review | HALO | |
Mismatch repair-deficient prostate cancer with parenchymal brain metastases treated with immune checkpoint blockade | Sena L, Salles D, Engle E, Zhu Q, Tukachinsky H, Lotan T, Antonarakis E | 2021 | Molecular Case Studies | Immuno-oncology | Highplex FL | HALO |
Lawsonia intracellularis infected enterocytes lack sucrase-isomaltase which contributes to reduced pig digestive capacity | Helm E, Burrough E, Leite, F, Gabler, N | 2021 | Veterinary Research | Other | ISH/FISH | HALO |
Mechanism of Nucleic Acid Sensing in Retinal Pigment Epithelium (RPE): RIG-I Mediates Type I Interferon Response in Human RPE | Schustak J, Twarog M, Wu X, Huang Q, Bao Y | 2021 | Journal of Immunology Research | Area Quantification, ISH/FISH | HALO | |
Rejection of benign melanocytic nevi by nevus-resident CD4+ T cells | Schiferle E, Cheon S, Ham S, Son H, Messerschmidt J, Lawrence D, Cohen J, Flaherty K, Moon J, Lian C, Sullivan R, Demehri S | 2021 | Science Advances | Oncology | Multiplex IHC | HALO |
Wound healing with topical BRAF inhibitor therapy in a diabetic model suggests tissue regenerative effects | Escuin-Ordinas H, Liu Y, Hufo W, Dimatteo R, Huang R, Krystofinski P, Azhdam A, Lee J, Comin-Anduix B, Cochran A, Lo R, Segura T, Scumpia P, Ribas A | 2021 | PLOS ONE | Dermatology | Object Colocalization, Multiplex IHC | HALO |
The Goto Kakizaki rat: Impact of age upon changes in cardiac and renal structure, function | Meagher P, Civitarese R, Lee X, Gordon M, Bugyei-Twum A, Desjardins J, Kabir G, Zhang Y, Kosanam H, Visram A, Leong-Poi H, Advani A, Connelly K | 2022 | PLOS ONE | Myology | Muscle Fiber | HALO |
Extensive Three-Dimensional Intratumor Proteomic Heterogeneity Revealed by Multiregion Sampling in High-Grade Serous Ovarian Tumor Specimens | Hunt A, Bateman N, Barakat W, Makohon-Moore S, Hood B, Conrads K, Zhou M, Calvert V, Pierobon M, Loffredo J, Litzi T, Oliver J, Mitchell D, Gist G, Rojas C, Blanton B, Robinson E, Odunsi K, Sood A, Casablanca Y, Darcy K, Schriver C, Petricoin E, Rao U, Maxwell G, Conrads T | 2021 | iScience | Multiplex IHC | HALO | |
Dissecting spatial heterogeneity and the immuneevasion mechanism of CTCs by single-cell RNA-seq in hepatocellular carcinoma | Sun Y, Wu L, Liu S, Jiang M, Hu B, Zhou K, Guo W, Xu Y, Zhong Y, Zhou X, Zhang Z, Liu G, Liu S, Shi Y, Ji Y, Du M, Li N, Li G, Zhao Z, Huang X, Xu L, Yu Q, Peng D, Qiu S, Sun H, Dean M, Wang X, Chung W, Dennison A, Zhou J, Hou Y, Fan J, Yang X | 2021 | Nature Communications | Oncology, Immuno-oncology | Highplex FL | HALO |
TMEM229A suppresses non?small cell lung cancer progression via inactivating the ERK pathway | Zhang X, He Y, Jiang Y, Bao Y, Chen Q, Xie D, Yu H, Wang X | 2021 | Oncology Reports | Multiplex IHC | HALO | |
Glucocorticoid receptor antagonism promotes apoptosis in solid tumor cells | Greenstein A, Hunt H | 2021 | Oncotarget | Multiplex IHC | HALO | |
Anti-tumor effects of RTX-240: an engineered red blood cell expressing 4-1BB ligand and interleukin-15 | McArdel S, Dugast A, Hoover M, Bollampalli A, Hong E, Castano Z Leonard S, Pawar S, Mellen J, Muriuki K, McLaughlin D, Bayhi N, Carpenter C, Turka L, Wickham T, Elloul S | 2021 | Cancer Immunology, Immunotherapy | Immuno-oncology | Highplex FL | HALO |
Immune checkpoint blockade in triple negative breast cancer influenced by B cells through myeloid-derived suppressor cells | Vito A, Salem O, El-Sayes N, MacFawn I, Portillo A, Milne K, Harrington D, Ashkar A, Wan Y, Workenhe S, Nelson B, Bruno T, Mossman K | 2021 | Communications Biology | Immuno-oncology | Cytonuclear | HALO |
Computational pathology reveals unique spatial patterns of immune response in H&E images from COVID-19 autopsies: preliminary findings | Corredor G, Toro P, Bera K, Rasmussen D, Viswanathan V, Buzzy C, Fu P, Barton L, Stroberg E, Duval E, Gilmore H, Mukhopadhyay, Madabhushi A | 2021 | Journal of Medical Imaging | Infectious Disease | HALO Link | |
Spatial mapping of protein composition and tissue organization: a primer for multiplexed antibody-based imaging | Hickey J, Neumann E, Radtke A, Camarillo J, Beuschel R, Albanese A, McDonough E, Hatler J, Wiblin A, Fisher J, Croteau J, Small E, Sood A, Caprioli R, Angelo R Nolan G, Chung K, Hewitt S, Germain R, Spraggins J, Lundberg E, Snyder M, Kelleher N, Saka S | 2021 | arxiv | Review | HALO | |
Chemokine-Capturing Wound Contact Layer Rescues Dermal Healing | Schirmer L, Atallah P, Freudenberg U, Werner C | 2021 | Advanced Science | Dermatology | Highplex FL, Layer Thickness | HALO |
Tertiary lymphoid structures critical for prognosis in endometrial cancer patients - a TransPORTEC study | Horeweg N, Workel, H, Loiero D, Church D, Vermij L, Léon-Castillo A, Krog R, de Boer S, Nout R, Powel M, Mileshkin L, MacKay H, Leary A, Singh N, Jürgenliemk-Schulz I, Creutzberg C, Koelzer V, Nijman H, Bosse T, Bruyn M | 2021 | Research Square | Multiplex IHC, TMA | HALO AI | |
White adipose tissue autophagy and adipose-liver crosstalk exacerbate nonalcoholic fatty liver disease in mice | Sakane S, Hikita H, Shirai K, Myojin Y, Sasaki Y, Kudo S, Fukumoto K, Mizutani N, Tahata Y, Makino Y, Yamada R, Kodama T, Sakamori R, Tatsumi T, Takehara T | 2021 | Cellular and Molecular Gasteroenterology and Hepatology | Metabolism | HALO | |
Neoadjuvant cabozantinib and nivolumab convert locally advanced hepatocellular carcinoma into resectable disease with enhanced antitumor immunity | Ho W, Zhu Q, Durham J, Popovic A, Xavier S, Leatherman J, Mohan A, Mo G, Zhang S, Gross N, Charmsaz S, Lin D, Quong D, Wilt B, Kamel I, Weiss M, Philosophe B, Burkhart R, Burns W, Schubert C, Ejaz A, He J, Deshpande A, Danilova L, Stein-O'Brien G, Sugar E, Laheru D, Anders R, Fertig E, Jaffee, E, Yarchoan M | 2021 | Nature Cancer | Oncology | HALO | |
SMAD4 represses FOSL1 expression and pancreatic cancer metastatic colonization | Dai C, Rennhack J, Arnoff T, Thaker M, Younger S, Doench J, Huang A, Yang A, Aguirre A, Wang B, Mun E, O'Connel J, Huang Y, Labella K, Talamas J, Li J, Ilic N, Hwang J, Hong A, Giacomelli A, Gjoerup O, Root D, Hahn W | 2021 | Cell Reports | Oncology | Area Quantification | HALO |
A single-dose mRNA vaccine provides a long-term protection for hACE2 transgenic mice from SARS CoV-2 | Huang Q, Ji K, Tian S, Wang F, Huang B, Tong Z, Tan S, Hao J, Wang Q, Tan W, Gao G, Yan J | 2021 | Nature Communications | Infectious Disease | Multiplex IHC | HALO |
Endothelial cell infection and dysfunction, immune activation in severe COVID-19 | Qin Z, Liu F, Blair R, Wang C, Yang H, Mudd J, Currey J, Iwanaga N, He J, Mi R, Han K, Midkiff C, Alam M, Aktas B, Heide R, Veazey R, Piedimonte G, Maness N, Ergün S, Mauvais-Jarvis F, Rappaport J, Kolls J, Qin X | 2021 | Theranostics | Immunology, Infectious Disease | Multiplex IHC, Spatial Analysis | HALO |
Histological Studies of the VentricularSubventricular Zone as Neural Stem Cell and Glioma Stem Cell Niche | Brockman A, Mobley B, Rebecca I | 2021 | Journal of Histochemistry & Cytochemistry | Review | HALO | |
The deletion of yeaJ gene facilitates Escherichia coli escape from immune recognition | Wang X, Lin X, Wan Z, Wang S, Zuo J, Wang Z, Xu Y, Han X, Miao J | 2021 | Journal of Bacteriology | HALO | ||
Naproxen chemoprevention promotes immune activation in Lynch syndrome colorectal mucosa | Reyes-Uribe L, Wu Wenhui, Gelincik O, Bommi P, Francisco-Cruz A, Solis L, Lynch P, Lim R, Stoffel E, Kanth P, Samadder N, Mork M, Taggart M, Milne G, Marnett L, Vornik L, Liu D, Revuelta M, Chang K, You Y, Kipelovich L, Wistuba I, Lee J, Sei S, Shoemaker R, Szabo E, Richmond E, Umar A, Perloff M, Brown P, Lipkin S, Vilar E | 2020 | The BMJ | Oncology, Gastroenterology | Classifier, Cytonuclear | HALO |
Repeated porphyrin lipoprotein-based photodynamic therapy controls distant disease in mouse mesothelioma via the abscopal effect | Lou J, Aragaki M, Bernards N, Kinoshita T, Mo J Motooka Y, Ishiwata T, Gregor A, Chee T, Chen Z, Chen J, Kaga K, Wakasa S, Zheng G, Yasufuku K | 2021 | Nanophotonics | Oncology | Cytonuclear | HALO |
Digital pathology in academia: Implementation and impact | Jones-Hall Y | 2021 | Lab Animal | Review | HALO | |
GOT1 inhibition promotes pancreatic cancer cell death by ferroptosis | Kremer D, Nelson B, Lin L, Yarosz E Halbrook C, Kerk S, Sajjakulnukit P, Myers A, Thurston G, Hou S, Carpenter E, Andren A, Nwosu Z, Cusmano N, Wisner S, Mbah N, Shan M, Das N, Magnuson B, Little A, Savani M, Ramos J, Gao T, Sastra S, Palermo C, Badgley M, Zhang L, Asara J, McBrayer S, Pasca di Magliano M, Crawford H, Shah Y, Olive K, Lyssiotis C | 2021 | Nature Communications | Oncology | HALO | |
A preclinical trial and molecularly-annotated patient cohort identify predictive biomarkers in homologous recombination deficient pancreatic cancer | Wang Y, Park J, Pacis A, Denroche R, Jang G, Zhang A, Cuggia A, Domecq C, Monlong J, Raitses-Gurevich M, Grant R, Borgida A, Holter S, Stossel C, Bu S, Masoomian M, Lungu I, Bartlett J, Wilson J, Gao Z, Riazalhosseini Y, Asselah J, Bouganim N, Cabrera T, Boucher L, Valenti D, Biagi J, Greenwood C, Polak P, Foulkes W, Golan T, O'Kane G, Fischer S, Knox J, Gallinger S, Zogopoulos G | 2020 | Clinical Cancer Research | Oncology | Classifier, Cytonuclear, Multiplex IHC | HALO |
Epigenetic modifications precede molecular alterations and drive human hepatocarcinogenesis | Czauderna C, Poplawski A, O'Roourke C, Castven D, Pérez-Aguilar B, Becker D, Heilmann-Heimbach S, Odenthal M, Amer W, Schmiel M, Drebber U, Binder H, Ridder D, Schindeldecker M, Straub B, Galle P, Andersen J, Thorgeirsson S, Park Y, Marquardt J | 2021 | JCI Insight | Oncology | Cytonuclear, TMA | HALO |
Allostatic hypermetabolic response in PGC1?/? heterozygote mouse despite mitochondrial defects | Rodriguez-Cuenca S, Lelliot C, Campbell M, Peddinti G, Martinuez-Uña M, Ingvorsen C, Dias A, Relat J, Mora S, Hyötyläinen T, Zorzano A, Orei? M, Bjursell M, Bohlooly-Y M, Lindén D, Vidal-Puid A | 2021 | The FASEB Journal | Metabolism | Vacuole | HALO |
Distinct immune signatures in peripheral blood predict chemosensitivity in intrahepatic cholangiocarcinoma patients | Wu T, Yang Y, Zheng B, Shi X, Li W, Ma W, Wang S, Li Z, Zhu Y, Wu J, Wang K, Zhao Y, Wu R, Sui C, Shen S, Wu X, Chen L, Yuan Z, Wang H | 2021 | Engineering | Oncology, Immunology | Highplex FL | HALO |
Constrictive and Hypertrophic Strictures in Ileal Crohns Disease | Liu Q, Zhang X, Ko H, Stocker D, Ellman J, Chen J, Hao Y, Bhardwaj S, Liang Y, Cho J, Colombel J, Taouli B, Harpaz N | 2021 | Clinical Gastroenterology and Hepatology | Gastroenterology | HALO | |
The amino acid transporter SLC7A5 is required for efficient growth of KRAS-mutant colorectal cancer | Najumudeen AK, Ceteci F, Fey SK, Hamm G, Steven RT, Hall H, Nikula CJ, Dexter A, Murta T, Race AM, Sumpton D, Vlahov N, Gay DM, Knight JRP, Jackstadt R, Leach JDG, Ridgway RA, Johnson ER, Nixon C, Hedley A, Gilroy K, Clark W, Malla SB, Dunne PD, Rodriguez-Blanco G, Critchlow SE, Mrowinska A, Malviya G, Solovyev D, Brown G, Lewis DY, Mackay GM, Strathdee D, Tardito S, Gottlieb E, CRUK Rosetta Grand Challenge Consortium, Takats Z, Barry ST, Goodwin RJA, Bunch J, Bushell M, Campbell AD, Sansom OJ | 2021 | Nature Genetics | Oncology | ISH/FISH | HALO |
HIF-independent synthetic lethality between CDK4/6 inhibition and VHL loss across species | Nicholson HE, Tariq Z, Housden BE, Jennings RB, Stransky LA, Perrimon N, Signoretti S, Kaelin WG | 2019 | Cancer Therapy | Oncology | HALO | |
Impact of TREM2 risk variants on brain region-specific immune activation and plaque microenvironment in Alzheimer's disease patient brain samples | Prokop S, Miller KR, Labra SR, Pitkin RM, Hoxha K, Narasimhan S, Changolkar L, Rosenbloom A, Lee VM-Y, Trojanowski JQ | 2019 | Acta Neuropathologica | Neuroscience | Classifier, Area Quantification | HALO |
ACT1 is required for murine IL-23-induced psoriasiform inflammation potentially independent of E3 ligase activity | Lipovsky A, Slivka PF, Su Z, Wang Y, Paulsboe S, Wetter J, Namovic MT, Gauvin D, Perron D, Gauld S, McGaragughty S, Goedken ER | 2021 | Journal of Investigative Dermatology | Immunology | Multiplex IHC | HALO |
Robust and persistent reactivation of SIV and HIV by N-803 and depletion of CD8+ cells | McBrien JB, Mavigner M, Li LF, Smith SA, White E, Tharp GK, Walum H, Busman-Suhay K, Aguilera-Sandoval CR, Thayer WO, Spagnuolo RA, Kovarova M, Wahl A, Cervasi B, Margolis DM, Vanderford TH, Carnathan DG, Paiardini M, Lifson JD, Lee JH, Safrit JT, Bosinger SE, Estes JD, Derdeyn CA, Garcia JV, Kulpa DA, Chahroudi A, Silvestri G | 2020 | Nature | Other | ISH/FISH | HALO |
Acute brain inflammation, white matter oxidative stress, and myelin deficiency in a model of neonatal intraventricular hemorrhage | Goulding DS, Vogel RC, Gensel JC, Morganti JM, Stromberg AJ, Miller BA | 2020 | Journal of Neuroscience | Immunology, Neuroscience | Area Quantification, Object Colocalization | HALO |
Pharmacologic modulation of RNA splicing enhances anti-tumor immunity | Lu S, De Neef E, Thomas J, Sabio E, Rousseau B, Gigoux M, Knorr D, Greenbaum B, Elhanti Y, Hogg S, Chow A, Ghosh A, Xie A, Zamarin D, Cui D, Erickson C, Singer M, Cho H, Wang E, Lu B, Durham B, Shah H, Chowell D, Gabel A, Shen Y, Liu J, Jin J, Rhodes M, Taylor R, Molina H, Wolchok J, Merghoub T, Diaz Jr. L, Abdel-Wahab O, Bradley B | 2021 | Cell | Oncology | Multiplex IHC | HALO |
CTLA-4 and PD-1 dual blockade induces SIV reactivation without control of rebound after antiretroviral therapy interruption | Harper J, Gordon S, Chan CN, Wang H, Lindemuth E, Galardi C, Falcinelli SD, Raines SLM, Read JL, Nguyen K, McGary CS, Nekorchuk M, Busman-Sahay K, Schawalder J, King C, Pino M, Micci L, Cervasi B, Jean S, Sanderson A, Johns B, Koblansky AA, Amrine-Madsen H, Lifson J, Margolis DM, Silvestri G, Bar KJ, Favre D, Estes JD, Paiardini | 2020 | Nature Medicine | Immunology, Infectious Disease | Cytonuclear, ISH/FISH | HALO |
Spatially organized multicellular immune hubs in human colorectal cancer | Pelka K, Hofree M, Chen J, Sarkizova S, Pirl J, Jorgji V, Bejnood A, Dionne D, Ge W, Xu K, Chao S, Zollinger D, Lieb D, Reeves J, Fuhrman C, Hoang M, Delorey T, Nguyen L, Waldman J, Klapholz M, Wakiro I, Cohen O, Albers, J, Smillie C, Cuoco M, Wu J, Su M, Yeung J, Vijaykumar B, Magnuson A, Asinovski N, Moll T, Goder-Reise M, Applebaum A, Brais L, DelloStritto L, Denning S, Phillips S, Hill E, Meehan J, Frederick D, Sharova T, Kanodia A, Todres E, Jane-Valbuena J, Biton M, Izar B, Lambden C, Clancy T, Bleday R, Melnitchouk N, Irani J, Kunitake H, Berger D, Srivastava A, Hornick J, Ogino S, Rotem A, Vigneau S, Johnson B, Corcoran R, Sharpe A, Kuchroo V, Ng K, Giannakis M, Nieman L, Boland G, Arguirre A, Anderson A, Rosenblatt-Rosen O, Regev A, Hachohen N | 2021 | Cell | Oncology | Spatial Analysis, Highplex FL | HALO |
Hepatic stellate cells suppress NK cell-sustained breast cancer dormancy | Correia A Guimaraes J, Auf der Maur P, et al. | 2021 | Nature | Immuno-oncology | Classifier | HALO |
Analysis of multispectral imaging with the AstroPath platform informs efficacy of PD-1 blockade | Berry S, Giraldo N, Green B, et al | 2021 | Science | Immuno-oncology | HALO | |
Cabozantinib for neurofibromatosis type 1related plexiform neurofibromas: a phase 2 trial | Fisher MJ, Shih C-S, Rhodes SD, Armstrong AE, Wolters PL, Dombi E, Zhang C, Angus SP, Johnson GL, Packer RJ, Allen JC, Ullrich NJ, Goldman S, Gutmann DH, Plotkin SR, Rosser T, Robertson KA, Widemann BC, Smith AE, Bessler WK, He Y, Park S-J, Mund JA, Jiang L, Bijangi-Vishehsaraei K, Robinson CT, Cutter GR, Korf BR, Neurofibromatosis Clinical Trials Consortium, Blakeley JO, Clapp DW | 2021 | Nature Medicine | Oncology | Area Quantification | HALO |
Olaparib and durvalumab in patients with germline BRCA-mutated metastatic breast cancer (MEDIOLA): an open-label, multicentre, phase 1/2, basket study | Domchek SM, Postel-Vinay S, Im S-A, Park YH, Delord J-P, Italiano A, Alexandre J, You B, Bastian S, Krebs MG, Wang D, Waqar SN, Lanasa M, Rhee J, Gao H, Rocher-Ros V, Jones EV, Gulati S, Coenen-Stass A, Kozarewa I, Lai Z, Angell HK, Opincar L, Herbolsheimer P, Kaufman B | 2020 | The Lancet Oncology | Oncology | Multiplex IHC | HALO |
Artificial Intelligence-Based Quantification of Epithelial Proliferation in Mammary Glands of Rats and Oviducts of Göttingen Minipigs | Hvid H, Skydsgaard M, Jensen NK, Vluff BM, Jensen HE, Oleksiewicz MB, Kvist PH | 2020 | Toxicologic Pathology | Toxicology | Area Quantification | HALO AI |
Interplay of somatic alterations and immune infiltration modulates response to PD-1 blockade in advanced clear cell renal cell carcinoma | Braun DA, Hou Y, Bakouny Z, Ficial M, Sant' Angelo M, Forman J, Ross-Macdonald P, Berger AC, Jegede OA, Elagina L, Steinharter J, Sun M, Wind=Rotolo M, Pignon J-C, Cherniack AD, Lichtenstein L, Neuberg D, Catalano P, Freeman GJ, Sharpe AH, McDermott DF, Van Allen EM, Signoretti S, Wu CJ, Shukla SA, Choueiri TK | 2020 | Nature Medicine | Immuno-oncology | Highplex FL, Partitions (tiles, margins) | HALO |
ARID1A influences HDAC1/BRD4 activity, intrinsic proliferative capacity and breast cancer treatment response | Nagarajan S, Rao SV, Sutton J, Cheeseman D, Dunn S, Papachristou EK, Prada J-EG, Couturier D-L, Kumar S, Kishore K, Chilamakuri CSR, Glont E, Goode EA, Brodie C, Guppy N, Natrajan R, Bruna A, Caldas C, Russel A, Siersbaek R, Yusa K, Chernukhin I, Carroll JS | 2020 | Nature Genetics | Oncology | Multiplex IHC | HALO |
Preoperative ipilimumab plus nivolumab in locoregionally advanced urothelial cancer: the NABUCCO trial | van Dijk N, Gil-Jimenez A, Silina K, Hendricksen K, Smit LA, de Feijter JM, van Montfoort ML, van Rooijen C, Peters D, Broeks A, van der Poel HG, Bruining A, Lubeck Y, Sikorska K, Boellaard TN, Kvistborg P, Vis DJ, Hooijberg E, Schumacher TN, van den Broek M, Wessels LFA, Blank CU, van Rhijn BW, van der Heijden MS | 2020 | Nature Medicine | Immuno-oncology | Classifier, Highplex FL | HALO |
Immunogenic Chemotherapy Enhances Recruitment of CAR-T Cells to Lung Tumors and Improves Antitumor Efficacy when Combined with Checkpoint Blockade | Srivastava S, Furlan SN, Jaeger-Ruckstuhl CA, Sarvothama M, Berger C, Smythe KS, Garrison SM, Specht JM, Lee SM, Amezquita RA, Voillet V, Muhunthan V, Yechan-Gunja S, Pillai SPS, Rader C, Houghton AM, Pierce RH, Gottardo R, Maloney DG, Riddell SR | 2020 | Cancer Cell | Immuno-oncology | Multiplex IHC, Highplex FL | HALO |
HIV-1-induced cytokines deplete homeostatic innate lymphoid cells and expand TCF7-dependent memory NK cells | Wang Y, Lifschitz L, Gellatly K, Vinton CL, Busman-Sahay K, McCauley S, Vangala P, Kim K, Derr, Jaiswall S, Kucukural A, McDonel P, Hunt PW, Greenough T, Houghton J, Somsouk M, Estes JD, Brenchley JM, Garber M, Deeks SG, Luban J | 2020 | Nature Immunology | Immunology, Infectious Disease | Area Quantification, Cytonuclear, ISH/FISH | HALO |
IL6/STAT3 Signaling Hijacks Estrogen Receptor ? Enhancers to Drive Breast Cancer Metastasis | Siersbæk R, Scabia V, Nagarajan S, Chernukhin I, Papachristou EK, Broome R, Johnston SJ, Joosten SEP, Green AR, Kumar S, Jones J, Omarjee S, Alvarez-Fernandez R, Glont S, Aitken SJ, Kishore K, Cheeseman D, Rakha EA, D'Santos C, Zwart W, Ruseel A, Brisken C, Carroll JS | 2020 | Cancer Cell | Oncology | Area Quantification, Multiplex IHC | HALO |
Multimodal treatment combining cold atmospheric plasma and acidic fibroblast growth factor for multi?tissue regeneration | Tan F, Rui X, Xiang X, Yu Z, Al-Rubeai M | 2021 | The FASEB Journal | Other | Multiplex IHC | HALO |
Promyelocytic leukemia protein promotes the phenotypic switch of smooth muscle cells in atherosclerotic plaques of human coronary arteries | Karle W, Becker S, Stenzel P, Knosalla C, Siegel G, Baum O, Zakrzewicz A, Berkholz J | 2021 | Clinical Science | Myology | Area Quantification, Object Colocalization | HALO |
The Unfolded Protein Response Mediator PERK Governs Myeloid Cell-Driven Immunosuppression in Tumors through Inhibition of STING Signaling | Mohamed E, Sierra RA, Trillo-Tinoco J, Cao Y, Innamarato P, Payne KK, Pulido M, Mandula J, Zhang S, Thevenot P, Biswas S, Abdalla SK, Costich TL, Hanggi K, Anadon CM, Flores ER, Haura EB, Mehrotra, Pilon-Thomas S, Ruffel B, Munn DH, Cubillos-Ruiz JR, Conejo-Garcia JR, Rodriguez PC | 2020 | Immunity | Immuno-oncology | Highplex FL | HALO |
Genomic analysis of Vascular Invasion in Hepatocellular Carcinoma (HCC) Reveals Molecular Drivers and Predictive Biomarkers | Krishnan MS, Rajan KD A, Park J, Arjunan V, Marques FJG, Bermudez A, Girvan OA, Hoang NS, Yin J, Nguyen MH, Kothary N, Pitteri S, Felsher DW, Dhanasekaran R | 2020 | Hepatology | Oncology | Multiplex IHC, TMA | HALO |
Dynamic Hydrogels for Prevention of Post?Operative Peritoneal Adhesions | Stapleton LM, Lucian HJ, Grosskopf AK, Smith AAA, Totherow KP, Woo YJ, Appel EA | 2021 | Advanced Therapeutics | Biomaterials | Area Quantification | HALO |
Efficacy and safety of a 3?in?1 antiaging night facial serum containing melatonin, bakuchiol, and ascorbyl tetraisopalmitate through clinical and histological analysis | Goldberg DJ, Mraz-Robinson D, Granger C | 2020 | Journal of Cosmetic Dermatology | Dermatology | Area Quantification, Layer Thickness | HALO |
ILC2-driven innate immune checkpoint mechanism antagonizes NK cell antimetastatic function in the lung | Schuijs MJ, Png S, Richard AC, Tsyben A, Hamm G, Stockis J, Garcia C, Panaud S, Nicholls A, Ros XR, Su J, Eldridge MD, Riedel A, Serrao EM, Rodewald H-R, Mack M, Shields JD, Cohen ES, McKenzie ANJ, Goodwin RJA, Brindle KM, Marioni JC, Halim TYF | 2020 | Nature Immunology | Immuno-oncology | Multiplex IHC | HALO |
Engineering functional microvessels in synthetic polyurethane random-pore scaffolds by harnessing perfusion flow | Wright MEE, Yu JK, Jain D, Maeda A, Yeh S-CA, DaCosta RS, Lin CP, Santerre JP | 2020 | Biomaterials | Biomaterials | Area Quantification | HALO |
Blockade of the co-inhibitory molecule PD-1 unleashes ILC2-dependent antitumor immunity in melanoma | Jacquelot N, Seillet C, Wang M et al. | 2021 | Nature Immunology | Immuno-oncology | Classifier, Highplex FL | HALO |
Expansion of Immature, Nucleated Red Blood Cells by Transient Low?Dose Methotrexate Immune Tolerance Induction in Mice | Tran JQ, Grover D, Zhang M, Stapels M, Brennan R, Bangari DS, Piepenhagen PA, Roberts E, Olivia P, Zubair F, Vela JL, Richards SM, Joseph AM | 2020 | Clinical & Experimental Immunology | Immunology | Area quantification | HALO |
The InSituPlex® Staining Method for Multiplexed Immunofluorescence Cell Phenotyping and Spatial Profiling of Tumor FFPE Samples | Manesse M, Patel KK, Bobrow M, Downing SR | 2020 | Biomarkers for Immunotherapy of Cancer | Oncology, Immuno-oncology | Highplex FL | HALO |
Highly efficient genome editing in primary human bronchial epithelial cells differentiated at air-liquid interface | Rapiteanu R, Karagyozova T, Zimmerman N, Singh K, Wayne G, Martufi M, Belyaev NN, Hessel EM, Michalovich D, Macarron R, Rowan WC, Cairns WJ, Roger J, Betts J, Beinke S, Maratou K | 2020 | European Respiratory Journal | Other | Highplex FL | HALO |
IBI112, a selective anti-IL23p19 monoclonal antibody, displays high efficacy in IL-23-induced psoriasiform dermatitis | Li L, Wu Z, Qiu X, Wu Y, Kuang Z, Wang L, Sun T, Liu Y, Yi S, Jing H, Zhou S, Chen B, Wu, D, Wu W, Liu J | 2020 | International Immunopharmacology | Immunology, Dermatology | Classifier, Layer Thickness | HALO |
A four-chemokine signature is associated with a T cell-inflamed phenotype in primary and metastatic pancreatic cancer | Romero JM, Grünwald BT, Jang G-H, Bavi PP, Jhaveri A, Masoomian M, Fischer SE, Zhang A, Denroche RE, Lungu IM, De Luca A, Bartlett JMS, Xu J, Li N, Dhaliwal S, Liang S-B, Chadwick D, Vyas F, Bronsert P, Khokha R, McGaha TL, Notta F, Ohashi PS, Done SJ, O'Kane GM, Wilson JM, Knox JJ, Connor A, Wang Y, Zogopoulos G, Gallinger S | 2020 | Clinical Cancer Research | Oncology | Immune | HALO |
A Dedicated Evolutionarily Conserved Molecular Network Licenses Differentiated Cells to Return to the Cell Cycle | Miao Z-F, Lewis MA, Cho CJ, Adkins-Threats M, Park D, Brown JW, Sun J-X, Burclaff JR, Kennedy S, Lu J, Mahar M, Vietor I, Huber LA, Davidson NO, Cavalli V, Rubin DC, Wang Z-N, Mills JC | 2020 | Developmental Cell | Oncology | Highplex FL | HALO |
Immune evasion before tumour invasion in early lung squamous carcinogenesis | Mascaux C, Angelova M, Vasaturo A, Beane J, Hijazi K, Anthoine G, Rothe F, Willard-Gallo K, Haller A, Ninane V, Burny A, Sculier J-P, Spira A, Galon J | 2019 | Nature | Oncology, Immuno-oncology | Multiplex-IHC | HALO |
Mobilization of CD8+ T cells via CXCR4 blockade facilitates PD-1 checkpoint therapy in human pancreatic cancer | Seo YD, Jiang X, Sullivan KM, Jalikis FG, Smythe KS, Abbasi A, Vignali M, Park JO, Daniel SK, Pollack SM, Kim TS, Yeung R, Crispe IN, Pierce RH, Robins H, Pillarisetty VG | 2019 | Clinical Cancer Research | Immuno-oncology | Cytonuclear | HALO |
STAT3 antisense oligonucleotide remodels the suppressive tumor microenvironment to enhance immune activation in combination with anti-PD-L1 | Proia T, Singh M, Woessner R, Carnevalli LS, Bommakanti G, Magiera L, Srinivasan SS, Grosskurth SE, Collins M, Womack C, Griffin M, Ye M, Cantin S, Russell DL, Xie M, Hughes AM, Deng N, Mele DA, Fawell SE, Barry ST, Reimer C, Barrett JC, McCoon P | 2020 | Clinical Cancer Research | Immuno-oncology | Multiplex IHC, Highplex FL | HALO |
Imaging Tumor-Infiltrating Lymphocytes in Brain Tumors with [64Cu]Cu-NOTA-anti-CD8-Positron Emission Tomography | Nagle V, Henry K, Hertz C, et al. | 2021 | Clinical Cancer Research | Immuno-oncology | Multiplex IHC | HALO |
Cooperative targeting of immunotherapy-resistant melanoma and lung cancer by an AXL-targeting antibody-drug conjugate and immune checkpoint blockade | Boshuizen J, Pencheva N, Krijgsman O, Altimari DD, Castro PG, de Bruijn B, Ligtenberg MA, den Heuvel EG, Vredevoogd DW, Song J-Y, Visser N, Apriamashvili G, Janmaat ML, Plantinga TS, Franken P, Houtkamp M, Lingnau A, Jure-Kunkel M, Peeper DS | 2021 | Cancer Research | Immuno-oncology | Multiplex-IHC | HALO |
Over-expression of Th2-related molecules in the skin of patients with eosinophilic dermatosis of hematologic malignancy | Maglie R, Ugolini F, De Logu F, Nassini R, Simi S, Nardiello P, Pasqualaini E, Baroini G, Del Bianco E, Massi D, Antiga E | 2021 | Journal of the American Academy of Dermatology | Oncology, Immuno-oncology | Area Quantification, Multiplex IHC | HALO Link |
Temporal Analysis of Amylase Expression in Control, Autoantibody Positive, and Type 1 Diabetes Pancreatic Tissues | Kusmartseva I, Beery M, Hiller H, Padilla M, Selman S, Posgai A, Nick HS, Campbell-Thompson M, Schatz DA, Haller MJ, Wasserfall CH, Atkinson MA | 2019 | Diabetes | Metabolism | Cytonuclear | HALO |
Kras and Lkb1 mutations synergistically induce intraductal papillary mucinous neoplasm derived from pancreatic duct cells | Collet L, Ghurburrun E, Meyers N, Assi M, Pirlot B, Leclercq IA, Couvelard A, Komuta M, Cros J, Demetter P, Lemaigre FP, Borbath I, Jacquemin P | 2019 | Gut | Oncology | Area Quantification | HALO |
Prognostic features of the tumour microenvironment in oesophageal adenocarcinoma | McShane R, Arya S, Stewart A, Caie P, Bates M | 2021 | Biochimica et Biophysica Acta (BBA) - Reviews on Cancer | Immuno-oncology, Review | Cytonuclear | HALO |
Mammalian Retinal Cell Quantification | Muthuswamy A, Chen H, Hu Y, Turner OC, Aina OH | 2020 | Toxicologic Pathology | Other | Cytonuclear | HALO |
Cx43 phosphorylation sites regulate pancreatic cancer metastasis | Solan JL, Hingorani SR, Lampe PD | 2021 | Oncogene | Oncology | Classifier, Area Quantification | HALO |
MAOA-mediated reprogramming of stromal fibroblasts promotes prostate tumorigenesis and cancer stemness | Li J, Pu T, Yin L, Li Q, Liao C-P, Wu BJ | 2020 | Oncogene | Oncology | Multiplex IHC | HALO |
Multimodal In Vivo and Post-mortem Assessments of Tau in Lewy Body Disorders | Coughlin DG, Phillips JS, Roll E, Peterson C, Lobrovich R, Rascovsky K, Ungrady M, Wolk DA, Das S, Weintraub D, Lee EB, Trojanowski JQ, Shaw LM, Vaishnavi S, Siderowf A, Nasrallah IM, Irwin DJ, McMillan CT | 2020 | Neurobiology of Aging | Neuroscience | Area Quantification | HALO |
B7-H3 immune checkpoint expression is a poor prognostic factor in colorectal carcinoma | Lu Z, Zhao Z-X, Cheng P, Huang F, Guan X, Zhang M-G, Chen H-P, Liu Z, Jiang Z, Zheng Z-X, Zou S-M, Wang X-S | 2020 | Modern Pathology | Immuno-oncology | Multiplex-IHC, TMA | HALO |
Chemoradiotherapy efficacy is predicted by intra-tumour CD8+/FoxP3+ double positive T cell density in locally advanced N2 nonsmall-cell lung carcinoma | Boulle G, Velut Y, Mansuet-Lupo A, Gibault L, Blons H, Fournel L, Boni A, Cremer I, Wislez M, Duchatelle V, Tredaniel J, Hammond SA, Herbst R, Alifano M, Giraud P, Damotte D | 2020 | European Journal of Cancer | Oncology | Highplex FL | HALO |
Neonatal hydrocephalus leads to white matter neuroinflammation and injury in the corpus callosum of Ccdc39 hydrocephalic mice | Goulding DS, Vogel RC, Pandya CD, Shula C, Gensel JC, Mangano FT, Goto J, Miller BA | 2020 | Journal of Neurosurgery | Immunology, Neuroscience | Multiplex IHC, Highplex FL | HALO |
The RAC1 target NCKAP1 plays a crucial role in progression of BRAF/PTEN -driven melanoma in mice | Swaminathan K, Campbell A, Papalazarou V, Jaber-Hijazi F, Nixon C, McGhee E, Strathdee D, Sansom OJ, Machesky LM | 2020 | Journal of Investigative Dermatology | Oncology, Dermatology | Area Quantification, Multiplex IHC | HALO |
Intraductal pancreatic cancer is less responsive than cancer in the stroma to neoadjuvant chemotherapy | Fujikura K, Hutchings D, Braxton AM, Zhu Q, Laheru DA, Hruban RH, Thompson ED, Wood LD | 2020 | Modern Pathology | Oncology | Multiplex IHC | HALO |
Phosphorylation of connexin 43 at MAPK, PKC or CK1 sites each distinctly alter the kinetics of epidermal wound repair | Lastwika JK, Dunn CA, Solan JL, Lampe PD | 2019 | Journal of Cell Science | Dermatology | Cytonuclear | HALO |
T-regulatory cells predict clinical outcome in soft tissue sarcoma patients: a clinico-pathological study | Smolle M, Herbsthofer L, Granegger B, Goda M, Brcic I, Bergovec M, Scheipl S, Prietl B, Pichler M, Gerger A, Rossmann C, Riedl J, Tomberger M, López-García P, El-Heliebi A, Leithner A, Liegl-Atzwanger B, Szkandera J | 2021 | British Journal of Cancer | Oncology | Highplex FL, TMA | HALO |
Quantitative digital image analysis of tumor-infiltrating lymphocytes in HER2-positive breast cancer | Abe N, Matsumoto H, Takamatsu R, Tamaki K, Takigami N, Uehara K, Kamada Y, Tamaki N, Motonari T, Unesoko M, Nakada N, Zaha N, Zaha H, Yoshimi N | 2019 | Vichows Archiv | Oncology | Classifier, Cytonuclear | HALO |
RNA isoform screens uncover the essentiality and tumor-suppressor activity of ultraconserved poison exons | Thomas JD, Polaski JT, Feng Q, De Neef EJ, Hoppe ER, McSharry MV, Pangallo J, Gabel AM, Belleville AE, Watson J, Nkinsi NT, Berger AH, Bradley RK | 2020 | Nature Genetics | Other | Highplex FL | HALO |
Glucagon Receptor Inhibition Reduces Hyperammonemia and Lethality in Male Mice with Urea Cycle Disorder | Cavino K, Sung B, Su Q, Na E, Kim J, Cheng X, Gromada J, Okamoto H | 2020 | Endocrinology | Metabolism | ISH/FISH, Multiplex IHC | HALO |
Characterization of the tumor immune microenvironment in human papillomavirus-positive and -negative head and neck squamous cell carcinomas | Succaria F, Kvistborg P, Stein JE, Engle EL, McMiller TL, Rooper LM, Thompson E, Berger AE, van den Brekel M, Zuur CL, Haanen J, Topalian SL, Taube JM | 2020 | Cancer Immunology, Immunotherapy | Immuno-oncology | Immune | HALO |
Temporospatial Development of Neuropathologic Findings in a Canine Model of Mucopolysaccharidosis IIIB | Harm TA, Hostetter SJ, Nenninger AS, Valentine BN, Ellinwood NM, Smith JD | 2020 | Veterinary Pathology | Immunology, Neruoscience | Area Quantification, Cytonuclear | HALO |
Development of a clinically relevant ovarian cancer model incorporating surgical cytoreduction to evaluate treatment of micro-metastatic disease | Morse CB, Voillet V, Bates BM, Chiu EY, Garcia NM, Gottardo R, Greenberg PD, Anderson KG | 2020 | Gynecologic Oncology | Oncology | Multiplex IHC | HALO |
PIK3CA mutation and CNV status and post-chemoradiotherapy survival in patients with cervical cancer | Martell K, McIntyre JB, Kornaga EN, Chan AMY, Phan T, Kobel M, Enwere EK, Dean ML, Ghatage P, Lees-Miller SP, Doll CM | 2020 | Gynecologic Oncology | Oncology | Classifier, Highplex FL, TMA | HAO |
Tumor Platinum Concentrations and Pathological Responses Following Cisplatin-Containing Chemotherapy in Gastric Cancer Patients | Cao Y, Chang Q, Cabanero M, Zhang W, Hafezi-Bakhtiari S, Hedley D, Darling G, Quereshy F, Jang R, Elimova E, Knox J, Ornatsky O, Serra S, Chen E | 2019 | Journal of Gastrointestinal Cancer | Oncology | Area Quantification, Cytonuclear | HALO |
PLX3397 treatment inhibits constitutive CSF1R-induced oncogenic ERK signaling, reduces tumor growth, and metastatic burden in osteosarcoma | Smeester BA, Slipek NJ, Pomeroy EJ, Laoharawee K, Osum SH, Larsson AT, Williams KB, Stratton N, Yamamoto K, Peterson JJ, Rathe SK, Mills LJ, Hudson WA, Crosby MR, Wang M, Rahramann EP, Moriarity SB, Largaespada DA | 2020 | Bone | Oncology | Cytonuclear, TMA | HALO |
IFN-III is selectively produced by cDC1 and predicts good clinical outcome in breast cancer | Hubert M, Gobbini E, Couillault C, Manh T-PV, Doffin A-C, Berthet J, Rodriguez C, Ollion V, Kielbassa J, Sajous C, Treilleux I, Tredan O, Dubois B, Dalod M, Bendriss-Vermare N, Caux C, Valladeau-Guilemond J | 2020 | Immunology | Oncology | Highplex FL, Partitions (tiles, margins) | HALO |
Using immuno-PET imaging to monitor kinetics of T cell-mediated inflammation and treatment efficiency in a humanized mouse model for GvHD | Pektor S, Schlöder J, Klasen B, Bausbacher N, Wagner D-C, Schreckenberger W, Grabbe S, Jonuleit H, Miederer M | 2019 | European Journal of Nuclear Medicine and Molecular Imaging | Immunology | Cytonuclear | HALO |
Association between CD8 and PD?L1 expression and outcomes after radical prostatectomy for localized prostate cancer | Vicier C, Ravi P, Kwak L, Werner L, Huang Y, Evan C, Loda M, Hamid AA, Sweeney CJ | 2020 | The Prostate | Immuno-oncology | Classifier, Highplex FL | HALO |
?-Synuclein modulates tau spreading in mouse brains | Bassil F, Meymand ES, Brown HJ, Xu H, Cox TO, Pattabhiraman S, Maghames CM, Wu Q, Zhang B, Trojanowski JQ, Lee VM-Y | 2020 | Journal of Experimental Medicine | Neuroscience | Area Quantification | HALO |
A locus coeruleus to dentate gyrus noradrenergic circuit modulates aversive contextual processing | Seo D, Zhang E, Piantadosi S, et al | 2021 | Neuron | Neuroscience | Area Quantification, Highplex FL | HALO |
Clinicopathological significance of nerves in esophageal cancer | Griffin N, Rowe CW, Gao F, Jobling P, Wills V, Walker MM, Faulkner S, Hondermarck H | 2020 | The American Journal of Pathology | Oncology | Area Quantification | HALO |
AST-120 Treatment Alters the Gut Microbiota Composition and Suppresses Hepatic Triglyceride Levels in Obese Mice | Hiraga Y, Kubota T, Katoh, M, et al. | 2021 | Endocrine Research | Metabolism | Vacuole | HALO |
High CD8+ tumour infiltrating lymphocyte density associates with unfavourable prognosis in oesophageal adenocarcinoma following poor response to neo?adjuvant chemoradiotherapy | Koemans WJ, van Dieren JM, van den Berg J, Meijer G, Snaebjornsson P, Chalabi M, Lecot F, Riedl R, Krijgsman O, Hofland I, Broeks A, Voncken FEM, Peppelenbosch MP, Sosef MN, van Sandick JW, Kodach LL | 2021 | Histopathology | Immuno-oncology | Cytonuclear | HALO |
High density of cytotoxic T-lymphocytes is linked to tumoral PD-L1 expression regardless of the mismatch repair status in colorectal cancer | Möller K, Blessin N, Höflmayer D, et al. | 2021 | Acta Oncologica | Immuno-oncology | Highplex FL | HALO |
Discoidin Domain Receptor 1 (DDR1) is Necessary for Tissue Homeostasis in Pancreatic Injury and Pathogenesis of Pancreatic Ductal Adenocarcinoma | Ruggeri JM, Franco-Barraza J, Sohail A, Zhang Y, Long D, di Magliano MP, Cukierman E, Fridman R, Crawford HC | 2020 | The American Journal of Pathology | Oncology, Immunology | Cytonuclear, Multiplex IHC, Highplex FL | HALO |
Chronic stress differentially alters mRNA expression of opioid peptides and receptors in the dorsal hippocampus of female and male rats | Johnson MA, Contoreggi NH, Kogan JF, Bryson M, Rubin BR, Gray JD, Kreek MJ, McEwen BS, Milner TA | 2021 | The Journal of Comparative Neurology | Neruoscience | ISH/FISH | HALO |
Monocyte and macrophage derived myofibroblasts: Is it fate? A review of the current evidence | Vierhout M, Ayoub A, Naiel S, Yazdanshenas P, Revill S, Reihani A, Dvorkin-Gheva A, Shi W, Ask K | 2021 | Wound Repair and Regeneration | Review | ISH/FISH | HALO |
Necroptosis in biliary atresia of the liver | Hashimoto M, Fujishima F, Lomphithak T, Jitkaew S, Nio M, Sasano H | 2021 | Medical Molecular Morphology | Metabolism | Multiplex IHC | HALO |
Intracranial administration of alpha-synuclein fibrils in A30P-synuclein transgenic mice causes robust synucleinopathy and microglial induction | Gentzel R, Toolan D, Jinn S, Schachter J, Ma L, Kahle P, Smith S, Marcus J | 2021 | Neurobiology of Aging | Neuroscience | Area Quantification | HALO |
A comparative study of cirrhosis sub-staging using the Laennec system, Beijing classification, and morphometry | Zhang X, Schiano T, Doyle E, Branch A, Florman S, Fiel M. | 2021 | Modern Pathology | Metabolism | Classifier, Area Quantification | HALO |
Alteration of Colonic Mucin Composition and Cytokine Expression in Acute Swine Dysentery | Lin S J-H, Arruda B, Burrough E | 2021 | Veterinary Pathology | Immunology | Area Quantification, ISH/FISH | HALO |
Selective loss of resident macrophage-derived insulin-like growth factor-1 abolishes adaptive cardiac growth to stress | Zaman R, Hamidzada H, Kantores C, Wong A, Dick S, Wang Y, Momen A, Aronoff L, Lin J, Razani B, Mital S, Billia F, Lavine K, Nejat S, Epelman S | 2021 | Immunity | Immunology | Highplex FL | HALO |
Ki-67 Proliferation Index Assessment in Gastroenteropancreatic Neuroendocrine Tumors by Digital Image Analysis With Stringent Case and Hotspot Level Concordance Requirements | Boukhar SA, Gosse MD, Bellizzi AM, Rajan A | 2021 | American Journal of Clinical Pathology | Oncology | Cytonuclear | HALO |
Establishing standardized immune phenotyping of metastatic melanoma by digital pathology | Sobottka B, Nowak M, Frei A, Haberecker M, Merki S, Tumor Profiler consortium, Levesque M, Dummer R, Moch H, Koelzer V | 2021 | Laboratory Investigation | Immuno-oncology | Multiplex IHC, Spatial Analysis | HALO AI |
Orexin receptors 1 and 2 in serotonergic neurons differentially regulate peripheral glucose metabolism in obesity | Xiao X Yeghiazaryan G, Hess S, Klemm P, Sieben A, Kleinridders A, Morgan D, Wunderlich F. Rahmouni K. Kong D, Scammell T, Lowell B, Kloppenburg P, Brüning J, Hausen A. | 2021 | Nature Communications | Metabolism | ISH/FISH | HALO |
Multiplex Immunohistochemical Phenotyping of T Cells in Primary Prostate Cancer | Ozbek B, Ertunc O, Erickson A, Vidal I, Alexandre C, Guner G, Hicks J, Jones T, Taube J, Sfanos K, Yegnasubramanian S, DeMarzo A | 2021 | medRxiv | Immuno-oncology | Classifier, Cytonuclear, Highplex FL, Serial Section, Registration | HALO |
Simultaneous targeting of TGF-b/PD-L1 synergizes with radiotherapy by reprogramming the tumor microenvironment to overcome immune evasion | Lan Y, Moustaga M, Knoll M, Xu C, Furkel J, Lazorchak A, Yeung T, Hasheminasab S, Jenkins M, Meister S, Yu H, Schlegel J, Marelli B, Tang Z, Qin G, Klein C, Qi J, Zhou C, Locke G, Krunic D, Derner M, Schwager C, Fontana R, Kriegsmann K, Jiang F, Rein K, Kriegsmann M, Debus J, Lo K, Abdollahi A | 2021 | Cancer Cell | Oncology | Cytonuclear | HALO |
SLFN11 captures cancer-immunity interactions associated with platinum sensitivity in high-grade serous ovarian cancer | Winkler C, King M, Berthe J, Ferraioli D, Garuti A, Grillo F, Rodriguez-Canales J, Ferrando L, Chopin N, Ray-Coquard I, Delpuech O, Bedognetti D, Ballestrero A, Leo E, Zoppoli G | 2021 | JCI Insight | Oncology | Classifier, Cytonuclear | HALO |
Three subtypes of lung cancer fibroblasts definedistinct therapeutic paradigms | Hu H, Peotrowska Z, Hare P, Chen H, Mulvey H, Mayfield A, Noeen S, Kattermann K, Greenberg M, Williams A, Riley A, Wilson J, Mao Y, Huang R, Banwait M, Ho J, Crowther G, Hariri L, Sequist L, Benes C, Niederst M, Engelman J | 2021 | Cancer Cell | Oncology | Cytonuclear, ISH/FISH | HALO |
NR4A1 regulates expression of immediate early genes, suppressing replication stress in cancer | Guo H, Golczer G, Wittner B, Langenbucher A, Zachariah M, Dubash T, Hong X, Comaills V, Burr R, Ebright R, Horwitz E, Vuille J, Hajizadeh S, Wiley D, Reeves B, Zhang J, Niederhoffer K, Lu C, Wesley B, Ho U, Nieman L, Toner M, Vasudevan S, Zou L, Mostoslavsky R, Maheswaran S, Lawrence M, Haber D | 2021 | Molecular Cell | Oncology | Highplex FL | HALO |
AG-205 Upregulates Enzymes Involved in Cholesterol Biosynthesis and Steroidogenesis in Human Endometrial Cells Independently of PGRMC1 and Related MAPR Proteins | Thieffry C, Van Wynendaele M, Aynaci A, Maja M, Dupuis C, Loriot A, Marbaix E, Henriet P | 2021 | Biomolecules | Other | Cytonuclear, Highplex FL | HALO |
p53-mediated redox control promotes liver regeneration and maintains liver function in response to CCl4 | Humpton T, Hall H, Kiourtis C, Nixon C, Clark W, Hedley A, Shaw R, Bird T, Blyth K, Vousden K | 2021 | Cell Death & Differentiation | Metabolism | Cytonuclear, Multiplex IHC | HALO |
Single-cell RNA transcriptome landscape of hepatocytes and non-parenchymal cells in healthy and NAFLD mouse liver | Su Q, Kim S, Adewale F, Zhou Y, Alder C, Ni M, Wei Y, Burcznski M, Atwal G, Sleeman M, Murphy A, Xin Y, Cheng X | 2021 | iScience | Metabolism | Area Quantification | HALO |
Functional heterogeneity of POMC neurons relies on mTORC1 signaling | Saucisse N, Mazier W, Simon V, Binder E, Catania C, Bellocchio L, Romanov R, Leon S, Matias I, Zizzari P, Quarta C, Cannich A, Meece K, Gonzales D, Clark S, Becker J, Yeo G, Fioramonti X, Merkle F, Wardlaw S, Harkany T, Massa F, Marsicano G, Cota D | 2021 | Cell Reports | Neuroscience | ISH/FISH | HALO |
Atypical chemokine receptor 3 (ACKR3) induces the perturbation of rRNA biogenesis in colonic cells: a novel mechanism of colorectal tumorigenesis | Yang J, Li Y, Pan T, Miao R, Zhang Y, Wu S, Qu X, Cui S | 2021 | Research Square | Oncology | Area Quantification | HALO |
IL-1-driven stromalneutrophil interactions define a subset of patients with inflammatory bowel disease that does not respond to therapies | Friedrich M, Pohin M, Jackson M, Korsunsky I, Bullers S, Rue-Albrecht K, Christoforidou Z, Sathananthan D, Thomas T, Ravindran R, Tandon R, Peres R, Sharpe H, Wei K, Watts G, Mann E, Geremia A, Attar M, Oxford IBD Cohort Investigators, Roche Fibroblast Network Consortium, McCuaig S, Thomas L, Collantes E, Uhlig H, Sansom S, Easton A, Raychaudhuri S, Travis S, Powrie F | 2021 | Nature Medicine | Gastroenterology | Cytonuclear | HALO |
Increased IL-6 expression precedes reliable viral detection in the rhesus macaque brain during acute SIV infection | Gopalakrishnan R, Aid M, Mercado N, Davis C, Malik S, Geiger E, Varner V, Jones R, Bosinger S, Piedra-Mora C, Martinot A, Barouch D, Reeves R, Tan C | 2021 | JCI Insight | Infectious Disease | Area Quantification | HALO |
Combined CTLA-4 and PD-L1 blockade in patients with chemotherapy-naïve metastatic castration-resistant prostate cancer is associated with increased myeloid and neutrophil immune subsets in the bone microenvironment | Subudhi S, Siddiqui B, Aparicio A, Yadav S, Basu S, Chen H, Jindal S, Tidwell R, Varma A, Logothetis C, Allison J, Corn P, Sharma P | 2021 | Journal for ImmunoTherapy of Cancer | Immuno-oncology | Cytonuclear, Multiplex IHC | HALO |
Expression of SARS-CoV-2 Entry Factors in the Pancreas of Normal Organ Donors and Individuals with COVID-19 | Kusmartseva I, Wu W, Syed F, Van Der Heide V, Jorgensen M, Joseph P, Tang X, Candelario-Jalil E, Yang C, Nick H, Harbert J, Posgai A, Paulsen J, Lloyd R, Cechin S, Pugliese A, Campbell-Thomson M, Vander Heide R, Evans-Molina C, Homann D, Atkinson M | 2020 | Cell Metabolism | Infectious Disease | Area Quantification | HALO |
Baricitinib Treatment Resolves Lower-Airway Macrophage Inflammation and Neutrophil Recruitment in Sars-Cov-2-Infected Rhesus Macaques | Hoang T, Pino M, Boddapati A, Viox E, Starke C, Upadhyay A, Gumber S, Nekorchuk M, Busman-Sahay K, Strongin Z, Harper J, Tharp G, Pellegrini K, Kirejczyk S, Zandi K, Tao S, Horton T, Beagle E, Mahar E, Lee M, Cohen J, Jean S, Wood J, Connor-Stroud F, Stammen R, Delmas O, Wang S, Cooney K, Sayegh M, Wang L, Filev P, Weiskopf D, Silvestri G, Waggoner J, Piantadosi A, Kasturi S, Al-Shakhshir H, Ribeiro S, Sekaly R, Levit R, Estes J, Vanderfold T, Schinazi R, Bosinger S, Paiardine M | 2021 | Cell | Infectious Disease | Multiplex IHC | HALO |
Diagnostic and prognostic implications of a three-antibody molecular subtyping algorithm for non-muscle invasive bladder cancer | Jackson C, Chen L, Hardy C, Ren K, Visram K, Bratti V, Johnstone J, Sjödahl G, Siemens D, Gooding R, Berman D | 2021 | The Journal of Pathology: Clinical Research | Oncology | Cytonuclear, TMA | HALO |
Transcriptomic Analysis of Healthy and Atopic Dermatitis Samples Reveals the Role of IL-37 in Human Skin | Zhou J, Gemperline D, Turner M, Oldach J, Molignano J, Sims J, Stayrook K | 2021 | ImmunoHorizons | Dermatology | Area Quantification, Cytonuclear | HALO |
Interleukin-33 activates group 2 innate lymphoid cell expansion and modulates endometriosis | Miller J, Lingegowda H, Symons L, Bougie O, Young S, Lessey B, Koti M, Tayade C | 2021 | JCI Insight | Other | Area Quantification, Cytonuclear | HALO |
Development of a novel humanized mouse model for improved evaluation of in vivo anti-cancer effects of anti-PD-1 antibody | Katano I, Hanazawa A, Otsuka I, Yamaguchi T, Mochizuki M, Kawai K, Ito R, Goto M, Kagawa T, Takahashi T | 2021 | Scientific Reports | Oncology | Cytonuclear, Multiplex IHC | HALO |
A comparability study of natural and deglycosylated PD-L1 levels in lung cancer: evidence from immunohistochemical analysis | Mei J, Xu J, Yang X, Gu D, Zhou W, Wang H, Liu C | 2021 | Molecular Cancer | Oncology | Cytonuclear, Multiplex IHC | HALO |
Automated Detection and Classification of Desmoplastic Reaction at the Colorectal Tumour Front Using Deep Learning | Nearchou I, Ueno H, Kajiwara Y, Lillard K, Mochizuki S, Takeuchi K, Harrison D, Caie P | 2021 | Cancers | Oncology | HALO AI | |
Mitochondria exert age-divergent effects on recovery from spinal cord injury | Stewart A, McFarlane K, Vekaria H, Bailey W, Slone S, Tranthem L, Zhang B, Patel S, Sullivan P, Gensel J | 2021 | Experimental Neurology | Neuroscience | Object Colocalization | HALO |
Large-Section Histopathology Can Better Indicate the Immune Microenvironment and Predict the Prognosis of Pancreatic Ductal Adenocarcinoma Than Small-Section Histopathology | Ding G, Guo M, Yang Y, Sun C, Wu S, Liu X, Wang J, Jiang H, Liu Y, Zheng J | 2021 | Frontiers in Oncology | Oncology | Multiplex IHC | HALO |
Androgen Receptor Signalling in Macrophages Promotes TREM-1-mediated Cancer Cell Line Migration and Invasion | Cioni B, Zaalberg A, van Beihnum J, Melis M, van Brugsteden J, Muraro M, Hooijberg E, Peters D, Hofland I, Lubeck Y, de Jong J, Sanders J, Vivie J, van der Poel J, Griffioen A, Zwart W, Bergman A | 2021 | Nature Communications | Oncology | Highplex FL, Partitions (tiles, margins) | HALO |
Dysregulation of Innate Lymphoid Cells in Patients with Active Rheumatoid Arthritis and Mice with Collagen-Induced Arthritis | Yang F, Luo X, Zhu W, Li J, Zheng Z, Zhu P | 2021 | Mediators of Inflammation | Spatial Analysis, Highplex FL | HALO | |
CD147 antibody specifically and effectively inhibits infection and cytokine storm of SARS-CoV-2 and its variants delta, alpha, beta, and gamma | Geng J, Chen L, Yuan Y, Wang K, Wang Y, Qin C, Wu G, Chen R, Zhang Z, Wei D, Du P, Zhang J, Lin P, Zhang K, Deng Y, Xu K, Liu J, Sun X, Guo T, Yang X, Wu J, Jiang J, Li L, Zhang K, Wang Z, Zhang J, Yan Q, Zhu H, Zheng Z, Miao J, Fu X, Yang F, Chen X, Tang H, Zhang Y, Shi Y, Zhu Y, Pei Z, Huo F, Liang X, Wang Y, Wang Q, Xie W, Li Y, Shi M, Bian H, Zhu P, Chen Z | 2021 | Signal Transduction and Targeted Therapy | Infectious Disease | Cytonuclear, Multiplex IHC, Highplex FL | HALO |
Suppression of insulin-induced gene 1 (INSIG1) function promotes hepatic lipid remodelling and restrains NASH progression | Azzu V, Vacca M, Kamzolas I, Hall Z, Leslie J, Carobbio S, Virtue S, Davies S, Lukasik A, Dale M, Bohlooly-Y M, Acharjee A, Linden D, Bidault G, Petsalaki E, Griffin J, Oakley F, Allison M, Vidal-Puig | 2021 | Molecular Metabolism | Metabolism | Area Quantification, Cytonuclear, Multiplex IHC | HALO |
An endogenous opioid circuit determines state-dependent appetitive behavior | Castro D, Oswell C, Zhang E, Pedersen C, Piantadosi S, Rossi M, Hunker A, Guglin A, Moron J, Zweifel L, Stuber G, Bruchas M | 2021 | bioRxiv | Neuroscience | Cytonuclear, Highplex FL | HALO |
A faithful in vivo model of human macrophages in metastatic melanoma | Voillet V, Berger T, McKenna K, Paulson K, Smythe K, Hunter D, Valente W, Weaver S, Campbell J, Kim T, Byrd D, Bielas J, Pierce R, Chapuis A, Gottardo R, Rongvaux | 2021 | bioRxiv | Cytonuclear, Multiplex IHC | HALO | |
Maternal platelets pass interstices of trophoblast columns and are not activated by HLA-G in early human pregnancy | Guettler J, Forstner D, Cvirn G, Maninger S, Brugger B Nonn O, Kupper N, Pritz E, Wernitznig S, Dohr G, Hutter H, Juch H, Isermann B, Kohli S, Gauster M | 2021 | Journal of Reproductive Immunology | Other | Cytonuclear, Highplex FL | HALO |
Absolute copy number fitting from shallow whole genome sequencing data | Sauer C, Eldridge M, Vias M, Hall J, Boyle S, Macintyre G, Bradley T, Markowetz F, Brenton J | 2021 | bioRxiv | Oncology | Classifier | HALO |
E3 ligase-inactivation rewires CBL interactome to elicit oncogenesis by hijacking RTKCBLCIN85 axis | Ahmed S, Buetow L, Gabrielsen M, Lilla S, Sibbet G, Sumpton D, Zanivan S, Hedley A, Clark W, Huang D | 2021 | Oncogene | Oncology | Cytonuclear, Multiplex IHC | HALO |
Detection of EpsteinBarr Virus in Periodontitis: A Review of Methodological Approaches | Tonoyan L, Chevalier M, Vincent-Bungnas S, Marsault R, Doglio A | 2021 | Mircroorganisms | Review | ISH/FISH, ISH-IHC/FISH-IF | HALO |
CYRI-A limits invasive migration through macropinosome formation and integrin uptake regulation | Le A, Yelland T, Paul N, Fort L, Nikolaou S, Ismail S, Machesky L | 2021 | Journal of Cell Biology | Other | Cytonuclear, Multiplex IHC | HALO |
Structure of the helicase core of Werner helicase, a key target in microsatellite instability cancers | Newman J, Gavard A, Lieb S, Ravichandran M, Hauer K, Werni P, Geist L, Bottcher J, Engen J, Rumpel K, Samwer M, Petronczki, Gileadi O | 2021 | Life Science Alliance | Oncology | Cytonuclear, Highplex FL | HALO |
In vitro amplification of pathogenic tau conserves disease-specific bioactive characteristics | Xu H, O'Reilly M, Gibbons G, Changolkar L, McBride J, Riddle D, Zhang B, Stieber A, Nirschl J, Kim S, Hoxha K, Brunden K, Schellenberg G, Trojanowski J, Lee V | 2021 | Acta Neuropathologica | Neruoscience | Cytonuclear, Multiplex IHC | HALO |
Cross-linking of T cell to B cell lymphoma by the T cell bispecific antibody CD20-TCB induces IFN?/CXCL10-dependent peripheral T cell recruitment in humanized murine model | Cremasco F, Menietti E, Speziale D, Sam J, Sammicheli S, Richard M, Varol A, Klein C, Umana P, Bacac M, Colombetti S, Perro M | 2021 | PLOS ONE | Oncology | Cytonuclear, Multiplex IHC, Highplex FL | HALO |
Tissue-resident FOLR2+ macrophages associate with tumor-infiltrating CD8+ T cells and with increased survival of breast cancer patients | Ramos, R, Missolo-Koussou Y, Gerber-Ferder Y, Bromley C, Bugatti M, Nunez N, Tosello J, Richer W, Denizeau J, Sedlik C, Caudana P, Kotsias F, Niborski L, Viel S, Bohec M, Lameiras S, Baulande S, Lesage L, Nicolas A, Mesure D, Vincent-Salomon A, Reyal F, Dutertre C, Ginhoux F, Vimeux L, Donnadieu E, Buttard B, Galon J, Zelenay S, Vermi W, Guermonprez P, Piaggio E, Helft J | 2021 | bioRxiv | Immuno-oncology | Cytonuclear, Highplex FL, TMA | HALO |
CCNE1 amplification is synthetic-lethal with PKMYT1 kinase inhibition | Gallo D, Young J, Fourtounis J, Martino G, Alvarez-Quilon A, Bernier C, Duffy N, Papp R, Roulston A, Stocco R, Szychowski J, Veloso A, Alam H, Baruah P, Fortin A, Bowlan J, Chaudhary N, Desjardins J, Dietrich E, Fournier S, Fugere-Desjardins C, de Rugy T, Leclaire M, Liu B, Melo H, Nicolas O, Singhania A, Szilard R, Tkac J, Yin S, Morris S, Zinda M, Marshall C, Duocher D | 2021 | bioRxiv | Other | Cytonuclear, Multiplex IHC | HALO |
MNK inhibition sensitizes KRAS-mutant colorectal cancer to mTORC1 inhibition by reducing eIF4E phosphorylation and c-MYC expression | Knight J, Alexandrou C, Skalka G, Vlahov N, Pennel K, Officer L, Teodosio A, Kanellos G, Gay D, May-Wilson S, Smith E, Najumudeen A, Gilroy K, Ridgway R, Flanagan D, Smith R, McDonald L, MacKay C, Cheasty A, McArthur K, Stanway E, Leach J, Jackstadt R, Waldron J, Campbell A, Vlachogiannis G, Valeri N, Haigis K, Sonenberg N, Proud C, Jones N, Swarbrick M, McKinnon H, Faller W, LeQuense J, Edwards J, Willis A, Bushell M, Sansom O | 2021 | Cancer Discovery | Oncology | Cytonuclear, Highplex FL | HALO |
Computational modeling of tau pathology spread reveals patterns of regional vulnerability and the impact of a genetic risk factor | Cornblath E, Li H, Changolkar C, Zhang B, Brown H, Gathagan R, Olufemi M, Trojanowski J, Bassett D, Lee V, Henderson M | 2021 | Science Advances | Neuroscience | Area Quantification | HALO |
Tau-tubulin kinase 1 phosphorylates TDP-43 at disease-relevant sites and exacerbates TDP-43 pathology | Tian Y, Wang Y, Jablonski A, Hu Y, Sugam J, Koglin M, Stachel S, Zhou H, Uslaner J, Parmentier-Batteur S | 2021 | Neurobiology of Disease | Neuroscience | Area Quantification | HALO |
Pilot study of Tremelimumab with and without cryoablation in patients with metastatic renal cell carcinoma | Campbell M, Matin S, Tam A, Sheth R, Ahrar K, Tidwell R, Rao P, Karam J, Wood C, Tannir N, Jonasch E, Gao J, Zurita A, Shah A, Jindal S, Duan F, Basu S, Chen H, Espejo A, Allison J, Yadav S, Sharma P | 2021 | Nature Communications | Oncology | Cytonuclear | HALO |
Cancer immune therapy with PD-1-dependent CD137 co-stimulation provides localized tumour killing without systemic toxicity | Qiao Y, Qiu Y, Ding J, Luo N, Wang H, Ling X, Sun J, Wu Z, Wang Y, Liu Y, Guo F, Sun T, Shen W, Zhang M, Wu D, Chen B, Xu W, Wang X | 2021 | Nature Communications | Immuno-oncology | Cytonuclear, Multiplex IHC | HALO |
Small molecule inhibitors of ?-synuclein oligomers identified by targeting early dopamine-mediated motor impairment in C. elegans | Chen K, Menezes K, Rodgers J, )'Hara D, Tran N, Fujisawa K, Ishikura S, Khodaei S, Chau H, Cranston A, Kapadia M, Pawar G, Ping S, Krizus A, Lacoste A, Spangler S, Visanji N, Marras C, Majbour N, El-Agnaf O, Lozano A, Culotti, Suo S, Ryu W, Kalia S, Kalia L | 2021 | Molecular Neurodegeneration | Neuroscience | Cytonuclear | HALO |
Intratumoral Heterogeneity and Immune Response Indicators to Predict Overall Survival in a Retrospective Study of HER2-Borderline (IHC 2+) Breast Cancer Patients | Radziuviene G, Rasmusson A, Augulis R, Grinevici |