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Click the tabs below to explore a few of our most popular applications for our suite of HALO products.


Spatial Characterization of the Tumor Microenvironment with Cell DIVE Multiplexed Imaging and HALO Quantitative Image Analysis

Quantitative evaluation of tumor tissues using a combined fluorescence in situ hybridization and immunofluorescence assay

Lung Macrodissect AI: a tumor cell estimation algorithm for use in a pulmonary adenocarcinoma molecular pathology workflow

An Automated Clinical Workflow Integrating an AI-driven PD-L1 22C3 Scoring Algorithm into a Browser-Based Digital Pathology Solution

Development & Validation of an AI-based Workflow for Clinical Scoring of HER2, ER, PR & Ki-67 Immunohistochemistry in Breast Cancer Tissue

Automated PD-L1 Tumor Proportion Scoring Algorithm in Non-Small Cell Lung Cancer for Multiple Companion Diagnostic Assays

An Automated Deep Learning Artifact Detection Tool for Quality Control of Whole-Slide Digital Pathology Images

Development & Validation of an AI based Tumour Cell Estimation Algorithm for Use in a Lung Adenocarcinoma Molecular Pathology Workflow

Novel CE-IVD clinical workflow for analysis of prostate cancer core needle biopsies

Characterizing the cellular architecture of TME using IMC and HALO

Automated tumor budding quantification in T1 colorectal carcinoma HE slides

Collaborative Poster with Lunaphore

Cytometric analysis of immune cell populations in clinical tumor biopsy tissue microarrays for immuno-oncology

Spatial multiplex profiling of immune cell markers in FFPE tumor tissues using the RNAscope™ HiPlex v2 in situ hybridization assay
RareCyte Indica Labs SITC 2021 Poster 56

CUSTOMER PUBLICATIONS

Indica Labs’ customers perform quantitative image analysis on research areas as diverse as immuno-oncology, toxicology, metabolism, and neuroscience. Check out the latest publications from our customers with HALO image analysis software! Click the navigation bar to sort according to Application, Journal, HALO Module, and more.

Title Authors Year Journal Application HALO Modules Product
Stem cellñderived CAR T cells traffic to HIV reservoirs in macaques Barber-Axthelm IM, Barber-Axthelm V, Sze KY, Zhen A, Suryawanshi GW, Chen ISY, Zack JA, Kitchen SG, Kiem H-P, Peterson CW 2021 JCI Insight Immunology, Infectious Disease Area Quantification HALO
IL-1-driven stromal-neutrophil interaction in deep ulcers defines a pathotype of therapy non-responsive inflammatory bowel disease Friedrich M, Pohin M, Jackson MA, Korsunsky I, Bullers S, Rue-Albrecht K, Christoforidou Z, Sathananthan D, Ravindran R, Peres RS, Sharpe H, Wei K, Watts GFM, Mann EH, Geremia A, Thomas T, Attar M, Oxford IBD Cohort Investigators, Roche Fibroblast Network Consortium, McCuaig S, Thomas L, Collantes E, Uhlig HH, Sansom S, Easton A, Raychaudhuri S, Travis SP, Powrie FM 2021 bioRxiv Immunology Cytonuclear HALO
Highly Fermentable Fiber Alters Fecal Microbiota and Mitigates Swine Dysentery Induced by Brachyspira hyodysenteriae Helm ET, Gabler NK, Burrough ER 2021 Animals Infectious Disease Cytonuclear HALO
Vascular endothelial ERp72 is involved in the inflammatory response in a rat model of skeletal muscle injury Khalaf NB, Al-Mehatab D, Fathallah DM 2021 Medicine Reports Immunology Cytonuclear HALO
Lipid Source and Peroxidation Status Alter Immune Cell Recruitment in Broiler Chicken Ileum Fries-Craft KA, Meyer MM, Lindblom SC, Kerr BJ, Bobeck EA 2021 The Journal of Nutrition Immunology ISH/FISH HALO
Frontotemporal lobar degeneration proteinopathies have disparate microscopic patterns of white and grey matter pathology Giannini LAA, Peterson C, Ohm D, Xie SX, McMillan CT, Raskovsky K, Massimo L, Suh E, Van Deerlin VM, Wolk DA, Trojanowski JQ, Lee EB, Grossman M, Irwin DJ 2021 Acta Neuropathologica Communications Neuroscience Area Quantification HALO
Fasting reverses drug-resistance in hepatocellular carcinoma through p53-dependent metabolic synergism Krstic J, Reinisch I, Schindlmaier K, Galhuber M, Berger N, Kupper N, Moyschewitz E, Auer M, Michenthaler H, NÀÜssing C, Depaoli MR, Ramadani-Muja J, Stryeck S, Pichler M, Rinner B, Deutsch AJA, Reinisch A, Madl T, Chiozzi RZ, Heck AJR, Huch M, Malli R, Prokesch A 2021 bioRxiv Oncology Classifier, Cytonuclear HALO
Recruitment of KRAS downstream target ARL4C to membrane protrusions accelerates pancreatic cancer cell invasion Harada A, Matsumoto S, Yasumizu Y, Akama T, Eguchi H, Kikuchi A 2021 bioRxiv Oncology Area Quantification HALO
Potential role of M2 TAMs around lymphatic vessels during lymphatic invasion in papillary thyroid carcinoma Kabasawa T, Ohe R, Aung NY, Urano Y, Kitaoka T, Tamazawa N, Utsunomiya A, Yamakawa M 2021 Scientific Reports Oncology Area Quantification HALO
Amylin deposition activates HIF1? and 6-phosphofructo-2-kinase/fructose-2, 6-biphosphatase 3 (PFKFB3) signaling in failing hearts of non-human primates Liu M, Li N, Qu C, Gao Y, Wu L, Hu LG 2021 Communications Biology Metabolism Area Quantification, Cytonuclear HALO
BMP pathway antagonism by Grem1 regulates epithelial
cell fate in intestinal regeneration
Koppens MAJ, Davis H, Valbuena GN, Mulholland EJ, Nasreddin N, Colombe M, Antanaviciute A, Biswas S, Friedrich M, Lee L, Oxford IBD cohort investigators, Wang LM, Koelzer VH, East JE, Simmons A, Winton DJ, Leedham SJ 2021 bioRxiv Gastroenterology Area Quantification HALO
A distinct repertoire of cancer-associated fibroblasts is enriched in cribriform prostate cancer Hesterberg AB, Rios BL, Wolf EM, Tubbs C, Wong HY, Schaffer KR, Lotan TL, Giannico GA, Gordetsky JB, Hurley PJ 2021 Journal of Pathology:Clinical Research Oncology Classifier, ISH/FISH HALO
Dystrophic microglia are associated with neurodegenerative disease and not healthy aging in the human brain Shahidehpour RK, Higdon RE, Crawford NG, Neltner JH, Ighodaro ET, Patel E, Price D, Nelson PT, Bachstetter AD 2021 Neurobiology of Aging Neuroscience Area Quantification HALO
Inhibition of Hedgehog signaling alters fibroblast composition in pancreatic cancer Steele NG, Biffi G, Kemp SB, Zhang Y, Drouillard D, Syu L-J, Hao Y, Oni TE, Brosnan E, Elyada E, Doshi A, Hansma C, Espinoza C, Abbas A, The S, Irizarry-Negron VM, Halbrook CJ, Franks N, Hoffman M, Brown KL, Carpenter ES, Nwosu ZC, Johnson C, Lima F, Anderson MA, Park Y, Crawford HC, Lyssiotis CA, Frankel TF, Rao A, Bednar F, Dlugosz AA, Preall J, Tuveson DA, Allen B, di Magliano MP 2021 Clinical Cancer Research Oncology Area Quantification HALO
Locally confined IFN? production by CD4+ T cells provides niches for murine cytomegalovirus
4 replication in the salivary gland
Oderbolz J, Zangger N, Zimmerman L, Sandu I, Starrufl J, Graw F, Oxenius A 2021 bioRxiv Classifier, Spatial Analysis, Highplex FL HALO
Kaiso (ZBTB33) subcellular partitioning functionally links LC3A/B, the tumor microenvironment, and breast cancer survival Singhal SK, Byun JS, Park S, Yan T, Yancey R, Caban A, Hernandez SG, Hewitt SM, Boisvert H, Hennek S, Bobrow M, Ahmed SU, White J, Yates C, Aukerman A, Vanguri R, Bareja R, Lenci R, FarrÈ PL, De Siervi A, N·poles AM, Vohra N, Gardner K 2021 Communications Biology Oncology Cytonuclear, TMA HALO
Deep Learning-Based Annotation Transfer between Molecular Imaging Modalities: An Automated Workflow for Multimodal Data Integration Race AM, Sutton D, Hamm G, Maglennon G, Morton JP, Strittmatter N, Campbell A, Sansom OJ, Wang Y, Barry ST, Tak·ts Z, Goodwin RJA, Bunch J 2021 Analytical Chemistry Oncology HALO AI
Integrative molecular characterization of sarcomatoid and rhabdoid renal cell carcinoma Bakouny Z, Braun DA, Shukla SA, Pan W, Gao X, Hou Y, Flaifel A, Tang S, Bosma-Moody A, He MX, Vokes N, Nyman J, Xie W, Nassar AH, Alaiwi SA, Flippot R, Bouchard G, Steinharter JA, Nuzzo PV, Ficial M, SantíAngelo M, Forman J, Berchuck JE, Dudani S, Bi K, Park J, Camp S, Sticco-Ivins M, Hirsch L, Baca SC, Wind-Rotolo M, Ross-Macdonald P, Sun M, Mary Lee G-SM, Chang SL, Wei XX, McGregor BA, Harshman LC, Genovese G, Ellis L, Pomerantz M, Hirsch MS, Freedman ML, Atkins MB, Wu CJ, Ho TH, Linehan WM, McDermott DF, Heng DYC, Viswanathan SR, Signoretti S, Van Allen EM, Choueiri TK 2021 Nature Communications Oncology Highplex FL HALO
IgA transcytosis and antigen recognition govern ovarian cancer immunity Biswas S, Mandal G, Payne KK, Anadon CM, Gatenbee CD, Chaurio RA, Costich TL, Moran C, Harro CM, Rigolizzo KE, Mine JA, Trillo-Tinoco J, Sasamoto N, Terry KL, Marchion D, Buras A, Wenham RM, Yu X, Townsend MK, Tworoger SS, Rodriguez CR, Anderson AR, Conejo-Garcia JR 2021 Nature Immuno-oncology Highplex FL HALO
Characterization of Macrophages and Osteoclasts in the Osteosarcoma Tumor Microenvironment at Diagnosis: New Perspective for Osteosarcoma Treatment? Gomez-Brouchet A, Gilhodes J, Van Acker N, Brion R, Bouvier C, Assemat P, Gaspar N, Aubert S, Guinebretiere J-M, Marie B, Larousserie F, Entz-WerlÈ N, de Pinieux G, Mascard E, Gouin F, Brousset P, Tabone M-D, Jimenez M, Le Deley M-C, Blay J-Y,
Brugieres L , Piperno-Neumann S, RÈdini F
2021 Cancers Immuno-oncology Highplex FL HALO
CD30+OX40+ Treg is associated with improved overall survival in colorectal cancer Lam JH, Hong M, Koo S-L, Chua CWL, Lim KL, Wee F, Wan WK, Leow WQ, Yeo JG, Tan IBH, Yeong J, Lim TKH, Lim TS 2021 Cancer Immunology, Immunotherapy Immuno-oncology Highplex FL HALO
Sustained Helicobacter pylori infection accelerates gastric dysplasia in a mouse model OíBrien VP, Koehne AL, Dubrulle J, Rodriguez AE, Leverich CK, Kong VP, Campbell JS, Pierce RH, Goldenring JR, Choi E, Salama NR 2021 Life Science Alliance Immuno-oncology Highplex FL HALO
A feasibility study of combined epigenetic and vaccine therapy in advanced colorectal cancer with pharmacodynamic endpoint Bever KM, Thomas DL, Zhang J, Rivera EAD, Rosner GL, Zhu Q, Nauroth JM, Christmas B, Thompson ED, Anders RA, Judkins C, Liu M, Jaffee EM, Ahuja N, Zheng L, Azad NS 2021 Clinical Epigenetics Oncology Immune, Membrane HALO
CD8+ T cells fail to limit SIV reactivation following ART withdrawal until after viral amplification Okoye AA, Duell DD, Fukazawa Y, Varco-Merth B, Marenco A, Behrens H, Chaunzwa TM, Selseth AN, Gilbride RM, Shao J, Edlefsen PT, Geleziunas R, Pinkevych M, Davenport MP, Busman-Sahay K, Nekorchuk MD, Park H, Smedley JV, Axthelm MK, Estes JD, Hansen SG, Keele BF, Lifson JD, Picker LJ 2021 The Journal of Clinical Investigation Immunology, Infectious Disease ISH/FISH HALO, HALO AI
The effect of cyfluthrin on testis inhibin B in rats and the intervention of Lycium barbarum polysaccharide Guo X, Xie Y-X, Guo C, Wei J-L, Yang H-F 2021 Molecular & Cellular Toxicology Toxicology Multiplex IHC HALO
Cooperative targeting of immunotherapy-resistant melanoma and lung cancer by an AXL-targeting antibody-drug conjugate and immune checkpoint blockade Boshuizen J, Pencheva N, Krijgsman O, Altimari DD, Castro PG, de Bruijn B, Ligtenberg MA, den Heuvel EG, Vredevoogd DW, Song J-Y, Visser N, Apriamashvili G, Janmaat ML, Plantinga TS, Franken P, Houtkamp M, Lingnau A, Jure-Kunkel M, Peeper DS 2021 Cancer Research Immuno-oncology HALO
ATP-binding cassette transporters restrict drug delivery and efficacy against brain tumors even when blood-brain barrier integrity is lost de Gooijer MC, Kemper EM, Buil LCM, Citirikkaya CH, Buckle T, Beijnen JH, van Tellingen O 2021 Cell Reports Medicine Oncology HALO
The amino acid transporter SLC7A5 is required for efficient growth of KRAS-mutant colorectal cancer Najumudeen AK, Ceteci F, Fey SK, Hamm G, Steven RT, Hall H, Nikula CJ, Dexter A, Murta T, Race AM, Sumpton D, Vlahov N, Gay DM, Knight JRP, Jackstadt R, Leach JDG, Ridgway RA, Johnson ER, Nixon C, Hedley A, Gilroy K, Clark W, Malla SB, Dunne PD, Rodriguez-Blanco G, Critchlow SE, Mrowinska A, Malviya G, Solovyev D, Brown G, Lewis DY, Mackay GM, Strathdee D, Tardito S, Gottlieb E, CRUK Rosetta Grand Challenge Consortium, Takats Z, Barry ST, Goodwin RJA, Bunch J, Bushell M, Campbell AD, Sansom OJ 2021 Nature Genetics Oncology HALO
Single-cell analysis shows that adipose tissue of persons with both HIV and diabetes is enriched for clonal, cytotoxic, and CMV-specific CD4+ T cells Wanjalla CN, McDonnell WY, Ram R, Chopra A, Gangula R, Leary S, Mashayekhi M, Simmons JD, Warren CM, Bailin S, Gabriel CL, Cuo L, Furch BD, Lima MC, Woodward BO, Hannah L, Pilkinton MA, Fuller DT, Kawai K, Virmani R, Finn AV, Hasty AH, Mallal SA, Kalams SA, Koethe JR 2021 Cell Reports Medicine Immunology, Metabolism HALO
Acute Respiratory Distress in Aged, SARS-CoV-2 Infected African Green Monkeys but not Rhesus Macaques Blair RV, Vaccari M, Doyle-Meyers LA, Roy CJ, Russell-Lodrigue K, Fahlberg M, Monjure CJ, Beddingfield B, Plante KS, Plante JA, Weaver SC, Qin X, Midkiff CC, Lehmicke G, Golden N, Threeton B, Penney T, Allers C, Barnes MB, Pattison M, Datta PK, Maness NJ, Birnbaum A, Fischer T, Bohm RP, Rappaport J 2020 The American Journal of Pathology Infectious Disease Classifier HALO
Association of COVID-19 inflammation with activation of the C5añC5aR1 axis Carvelli J, Demaria O, Vely F, Batista L, Benmansour NC, Fares J, Carpentier S, Thibult M-L, Morel A, Andre P, Represa A, Piperoglou C, Cordier PY, Le Dault E, Guervilly C, Simone P, Gainnier M, Morel Y, Ebbo M, Schleinitz N, Vivier E 2020 Nature Immunology Cytonuclear HALO
Impact of Preanalytical Factors During Histology Processing on Section Suitability for Digital Image Analysis Chlipala EA, Butters M, Brous M, Fortin JS, Archuletta R, Copeland K, Bolon B 2020 Toxicologic Pathology Toxicology Area Quantification, Cytonuclear HALO
Tumor vessel normalization, immuno-stimulatory reprogramming, and improved survival in glioblastoma with combined inhibition of PD-1, angiopoietin-2, and VEGF Di Tacchio M, Macas J, Weissenberger J, Sommer K, B‰hr O, Steinbach JP, Senft C, Seifert V, Glas M, Herrlinger U, Krex D, Meinhardt M, Weyerbrock A, Timmer M, Goldbrunner R, Deckert M, Scheel AH, B¸ttner R, Grauer OM, Schittenhelm J, Tabatabai G, Harter PN, Guenther S, Devraj K, Plate KH, Reiss Y 2020 Cancer Immunology Research Oncology, Immuno-oncology Classifier, Cytonuclear HALO
Immune cell landscaping reveals a protective role for regulatory T cells during kidney injury and fibrosis do Valle Duraes F, Lafont A, Biebel M, Martin K, Darribat K, Cuttat R, Waldt A, Naumann U, Wieczorek G, Gaulis S, Pfister S, Mertz KD, Li J, Roma G, Warncke M 2020 JCI Insight Immunology Area Quantification, Cytonuclear HALO
The prevalence and prognostic significance of estrogen receptor beta expression in non-small cell lung cancer Enwere EK, Dean ML, Li H, D'Silva A, Bebb DG 2020 Translational Lung Cancer Research Oncology Cytonuclear, TMA HALO
Dendritic Cell Paucity Leads to Dysfunctional Immune Surveillance in Pancreatic Cancer Hedge S, Krisnawan VE, Herzog BH, Zuo C, Breden MA, Knolhoff BL, Hogg GD, Tang JP, Baer JM, Mpoy C, Lee KB, Alexander KA, Rogers BE, Murphy KM, Hawkins WG, Fields RC, DeSelm CJ, Schwarz JK, DeNardo DG 2020 Cancer Cell Oncology, Immuno-oncology Area Quantification, Cytonuclear, Immune HALO
Periconceptional exposure to lopinavir, but not darunavir, impairs decidualization: a potential mechanism leading to poor birth outcomes in HIV-positive pregnancies Kala S, Dunk C, Acosta S, Serghides L 2020 Human Reproduction Infectious Disease Cytonuclear HALO
Three-dimensional culture models mimic colon cancer heterogeneity induced by different microenvironments Kawai S, Yamazaki M, Shibuya K, Yamazaki M, Fujji E, Nakano K, Suzuki M 2020 Scientific Reports Oncology Cytonuclear HALO
Epithelial-mesenchymal transition of absorptive enterocytes and depletion of Peyer's patch M cells after PEDV infection Chen Y-M, Helm ET, Groeltz-Thrush, Gabler NK, Burrough ER 2020 Virology Immunology Area Quantification HALO
Imaging breast cancer using hyperpolarized carbon-13 MRI Gallagher FA, Woitek R, McLean MA, Gill AB, Garcia RM, Provenzano E, Riemer F, Kaggie J, Chhabra A, Ursprung S, Grist JT, Daniels CJ, Zaccagna F, Laurent M-C, Locke M, Hilborne S, Frary A, Torheim T, Boursnell C, Schiller A, Patterson I, Slough R, Carmo B, Kane J, Biggs H, Harrison E, Deen SS, Patterson A, Lanz T, Kingsbury Z, Ross M, Basu B, Baird R, Lomas DJ, Sala E, Wason J, Rueda OM, Chin S-F, Wilkinson IB, Graves MJ, Abraham JE, Gilbert FJ, Caldas C, Brindle KM 2020 Proceedings of the National Academy of Sciences Oncology Area Quantification HALO
Conformation-selective tau monoclonal antibodies inhibit tau pathology in primary neurons and a mouse model of Alzheimerís disease Gibbons GS, Kim S-J, Wu Q, Riddle DM, Leight SN, Changolkar L, Xu H, Meymand ES, O'Reilly M, Zhang B, Brunden KR, Trojanowski JQ, Lee VMY 2020 Molecular Neurodegeneration Neuroscience Area Quantification HALO
TGF?-blockade uncovers stromal plasticity in tumors by revealing the existence of a subset of interferon-licensed fibroblasts Grauel AL, Nguyen B, Ruddy D, Laszewski T, Schwartz S, Chang J, Chen J, Piquet M, Pelletier M, Yan Z, Kirkpatrick ND, Wu J, deWeck A, Riester M, Hims M, Geyer FC, Wagner J, MacIsaac K, Deeds J, Diwanji R, Jayaraman P, Yu Y, Simmons Q, Weng S, Raza A, Minie B, Dostalek M, Chikkegowda P, Ruda V, Iartchouk O, Chen N, Thierry R, Zhou J, Pruteanu-Malinici I, Fabre C, Engelman JA, Dranoff G, Cremasco V 2020 Nature Communications Oncology Area Quantification HALO
Ex-vivo delivery of monoclonal antibody (Rituximab) to treat human donor lungs prior to transplantation Ku TJY, Ribeiero RVP, Ferreira VH, Galasso M, Keshavjee S, Kumar D, Cypel M, Humar A 2020 EBioMedicine Other Classifier, Cytonuclear HALO
Transmission of tauopathy strains is independent of their isoform composition He Z, McBride JD, Zu, Changolkar L, Kim S, Zhang B, Narasimhan S, Gibbons GS, Kozak M, Schellenberg GD, Trrojanowski JQ, Lee VM-Y 2020 Nature Communications Neuroscience Area Quantification HALO
Human cardiac fibroblasts expressing VCAM1 improve heart function in postinfarct heart failure rat models by stimulating lymphangiogenesis Iwamiya T, Segnard B-D, Matsuoka Y, Imamura T 2020 PLOS One Myology Area Quantification HALO
Environmental contaminant ammonia triggers epithelial-to-mesenchymal transition-mediated jejunal fibrosis with the disassembly of epithelial cell-cell contacts in chicken Jing H, Wang S, Wang Y, Shen N, Gao X-J 2020 ScienceTotalEnvrt Toxicology Area Quantification HALO
Cholinergic receptors on intestine cells of Ascaris suum and activation of nAChRs by levamisole McHugh M, Williams P, Verma S, Powell-Coffman JA, Robertson AP, Martin RJ 2020 International Journal for Parasitology: Drugs and Drug Resistance Gastroenterology, Infectious Disease Area Quantification HALO
Adult onset pan-neuronal human tau tubulin kinase 1 expression causes severe cerebellar neurodegeneration in mice McMillan P, Wheeler J, Gatlin RE, Taylor L, Strovas T, Baum M, Bird TD, Latimer C, Keene CD, Kraemer BC, Liachko NF 2020 Acta Neuropathologica Communications Neuroscience Area Quantification HALO
Spatial immune profiling of the colorectal tumor microenvironment predicts good outcome in stage II patients Nearchou IP, Gwyther BM, Georgiakakis ECT, Gavriel CG, Kajiwara Y, Ueno H, Harrison DJ, Caie PD 2020 Digital Medicine Immuno-oncology Classifier, Area Quantification, Spatial Analysis HALO
11? hydroxysteroid dehydrogenase 1: a new marker for predicting response to immune-checkpoint blockade therapy in non-small-cell lung carcinoma Saito R, Miki Y, Abe T, Miyauchi E, Abe J, Nanamiya R, Inoue C, Sato I, Sasano H 2020 British Journal of Cancer Immuno-oncology Area Quantification HALO
Clinicopathological significance of endoplasmic reticulum stress proteins in ovarian carcinoma Samanta S, Tamura S, Dubeau L, Mhawech-Fauceglia P, Miyagi Y, Kato H, Lieberman R, Buckanovich RJ, Lin YG, Neamati N 2020 Scientific Reports Oncology Area Quantification HALO
Prognostic value of tumor-inltrating immune cells in primary colorectal cancer and metastases Martin SZ, Tagscherer KE, Deckert S, Horst D, Moehler M, Lang H, Roth W 2020 *Pre-Print Immuno-oncology Classifier, Cytonuclear HALO
Implementation of PD-L1 22C3 IHC pharmDxTM in Cell Block Preparations of Lung Cancer: Concordance with Surgical Resections and Technical Validation of CytoLytÆ Prefixation Lou SK, Ko HM, Kinoshita T, MacDonald S, Weiss J, Czarnecka-Kujawa K, Boerner SL, Yasufuku K, Tsao M-S, Schwock J 2020 Acta Cytologica Oncology Classifier, Membrane HALO
Immuno-Interface Score to Predict Outcome in
Colorectal Cancer Independent of Microsatellite
Instability Status
Nestarenkaite A, Fadhil W, Ramusson A, Susanti S, Hadjimichael E, Laurinaviciene A, Ilyas M, Laurinavicius A 2020 Cancers Immuno-oncology Classifier, Multiplex IHC HALO
Assessment of associations between clinical and immune microenvironmental factors and tumor mutation burden in resected nonsmall cell lung cancer by applying machine learning to whole-slide images Ono A, Terada Y, Kawata T, Serizawa M, Isaka M, Kawabata T, Imai T, Mori K, Muramatsu K, Hayashi I, Kenmotsu H, Oshima K, Urakami K, Nagashima T, Kusuhara M, Akiyama Y, Sugino T, Ohde Y, Yamaguchi K, Takahashi T T 2020 Cancer Medicine Classifier, Multiplex IHC, Serial Section HALO
Prevalence of CD8+ cytotoxic lymphocytes in human neoplasms Blessin NC, Spriestersbach P, Li W, Mandelkow T, Dum D, Simon R, Hube-Magg C, Lutz F, Viehweger F, Lennartz M, Fraune C, Nickelsen V, Fehrle W, Gˆbel C, Weidemann S, Clauditz T, Lebok P, Mˆller K, Steurer S, Izbicki JR, Sauter G, Minner S, Jacobsen F, Luebke AM, B¸scheck F, Hˆflmayer D, Wilczak W, Burandt E, Hinsch A 2020 Cellular Oncology Oncology, Immuno-oncology Membrane, TMA HALO
Persistence of adoptively transferred T cells with a kinetically engineered IL-2 receptor agonist Parisi G, Saco JD, Salazar FB, Tsoi J, Krystofinski P, Puig-Saus C, Zhang R, Zhou J, Cheung-Lau GC, Garcia AJ, Grasso CS, TavarÈ R, Hu-Lieskovan S, Mackay S, Zalevsky J, Bernatchez C, Diab A, Wu AM , Comin-Anduix B, Charych D, Ribas A 2020 Nature Communications Oncology, Immuno-oncology Cytonuclear HALO
Mechanical regulation of glycolysis via cytoskeleton architecture Park JS, Burckhardt CJ, Lazcano R, Solis LM, Isogai T, Li L, Chen CS, Gao B, Minna JD, Bachoo R, DeBerardinis RJ, Danuser G 2020 Nature Oncology Classifier, Cytonuclear, TMA HALO
Naproxen chemoprevention promotes immune activation in Lynch syndrome colorectal mucosa Reyes-Uribe L, Wu W, Gelincik O, Bommi PV, Francisco-Cruz A, Solis LM, Lynch PM, Lim R, Stoffel EM, Kanth P, Samadder NJ, Mork ME, Taggart MW, Milne GL, Marnett LJ, Vornik L, Liu DD, Revuelta M, Chang K, You YN, Kopelovich L, Wistuba II, Lee JJ, Sei S, Shoemaker RH, Szabo E, Richmond E, Umar A, Perloff M, Brown PH, Lipkin SM, Vilar E 2020 Gut Oncology Classifier, Cytonuclear HALO
p53 is associated with high-risk and pinpoints TP53 missense mutations in mantle cell lymphoma Rodrigues JM, Hassan M, Freiburghaus C, Eskelund CW, Geisler C, Raty R, Kolstad A, Sundstrom C, Glimelius I, Gronbaek K, Kwiecinska A, Porwit A, Jerkeman M, Ek S 2020 British Journal of Haematology Oncology Classifier, Cytonuclear HALO
RUNX1 is a driver of renal cell carcinoma correlating with clinical outcome Rooney N, Mason SM, McDonald L, D‰britz HM, Campbell KJ, Hedley A, Howard S, Athineos D, Nixon C, Clark W, Leach JDG, Samsom OJ, Edwards J, Cameron ER, Blyth K 2020 Cancer Research Oncology Cytonuclear HALO
Analytical Performance of an Immunoprofiling Assay Based on RNA Models Schillebeeckx I, Armstrong JR, Forys JT, Hiken J, Earls J, Flanagan KC, Cui T, Glasscock JI, Messina DN, Duncavage EJ 2020 The Journal of Molecular Diagnostics Immunology Cytonuclear HALO
Prognostic significance of mesothelin expression in colorectal cancer disclosed by area-specific four-point tissue microarrays Shiraishi T, Shinto E, Nearchou IP, Tsuda H, Kajiwara Y, Einama T, Caie PD, Kishi Y, Ueno H 2020 Vichows Archiv Oncology Cytonuclear, TMA HALO AI
Prognostic and Predictive Value of Tumor-infiltrating Leukocytes and of Immune Checkpoint Molecules PD1 and PDL1 in Clear Cell Renal Cell Carcinoma Stenzel PJ, Schindeldecker M, Teagscherer KE, Foersch S, Herpel E, Hohenfellner M, Hatiboglu G, Alt J, Thomas C, Haferkamp A, Roth W, Macher-Goeppinger S 2020 Translational Oncology Oncology, Immuno-oncology Classifier, Cytonuclear, TMA HALO
Linking epigenetic signature and metabolic phenotype in IDH mutant and IDH wildtype diffuse glioma Buran Y, Filipski K, Bernatz S, Baumgarten P, Roller B, Zinke J, Zeiner PS, Ilina E, Senft C, Ronellenfitsch MW, Plate KH, B‰hr O, Hattingen E, Steinbach JP, Mittelbron M, Harter PN 2020 Neuropathology and Applied Neurobiology Neuroscience Multiplex IHC, TMA HALO
O 6-Methylguanine DNA Methyltransferase and Glucose Transporter 2 in Foregut and Hindgut Gastrointestinal Neuroendocrine Neoplasms Watanbe H, Yamazaki Y, Fujishima F, Izxumi K, Imamura M, Hijioka S, Toriyama K, Yatabe Y, Kudo A, Motoi F, Unno M, Sasano H 2020 BMC Cancer Oncology Cytonuclear HALO
SLFN11 informs on standard of care and novel treatments in a wide range of cancer models Winkler C, Armenia J, Jones GN, Tobalina L, Sale MJ, Petreus T, Baird T, Serra V, Wang AT, Lau A, Garnett MJ, Jaaks P, Coker EA, Pierce AJ, O'Connor MJ, Leo E 2020 British Journal of Cancer Oncology Classifier, Cytonuclear HALO
Lung Expression of Human ACE2 Sensitizes the Mouse to SARS-CoV-2 Infection Han K, Blair RV, Iwanaga N, Liu F, Russell-Lodrigue KE, Qin Z, Midkiff CC, Golden NA, Doyle-Meyers LA, Kabir ME, Chandler KE, Cutrera KL, Ren M, Monjure CJ, Lehmicke G, Fischer T, Beddingfield B, Wanek AG, Birnbaum A, Maness NJ, Roy CJ, Datta PK, Rappaport J, Kolls JK, Qin X 2020 American Journal of Respiratory Cell and Molecular Biology Infectious Disease HALO AI
Human ileal organoid model recapitulates clinical incidence of diarrhea associated with small molecule drugs Belair DG, Visconti RJ, Hong M, Marella M, Peters MF, Scott CW, Kolaja KL 2020 Toxicology in Vitro Toxicology Highplex FL HALO
Multiomic analysis and immunoprofiling reveal distinct subtypes of human angiosarcoma Chan JY, Lim JQ, Yeong J, Ravi V, Guan P, Boot A, Tay TKY, Selvarajan S, Nasir NDM, Loh JH, Ong CK, Huang D, Tan J, Li Z, Ng CC-Y, Tan TT, Masuzawa M, Sung KW-K, Farid M, Quek RHH, Tan NC, Teo MCC, Rozen SG, Tan P, Fotreal A, The BT, Soo KC 2020 The Journal of Clinical Investigation Immuno-oncology Highplex FL HALO
Tumoral PD-1hiCD8+ 1 T cells are partially exhausted and 2 predict favorable outcome in triple-negative breast cancer Guo L, Cao C, Goswami S, Huang X, Ma L, Guo Y, Yang B, Li T, Chi Y, Zhang X, Wu J 2020 Clinical Science Immuno-oncology Highplex FL HALO
CXCR4+ cells are increased in lung tissue of patients with idiopathic pulmonary fibrosis Jaffar J, Griffiths K, Oveissi S, Duan M, Foley M, Glaspole I, Symons K, Organ L, Westfall G 2020 Respiratory Research Fibrosis Highplex FL HALO
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Insoluble Tau From Human FTDP-17 Cases Exhibit Unique Transmission Properties In Vivo Weitzman SA, Narasimhan S, He Z, Changolkar L, McBride JD, Zhang B, Schellenberg GD, Trojanowski JQ, Lee VMY 2020 Journal of Neuropathology & Experimental Neurology Neuroscience HALO
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Cutaneous pharmacologic cAMP induction induces melanization of the skin and improves recovery from ultraviolet injury in melanocortin 1 receptor?intact or heterozygous skin Bautista R-M, Carter KM, Jarrett SG, Napier D, Wakamatsu K, Ito S, D'Orazio JA 2019 Pigment Cell & Melanoma Research Dermatology Area Quantification HALO
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Magnetic Resonance Imaging as a Biomarker in Rodent Peripheral Nerve Injury Models Reveals an Age-Related Impairment of Nerve Regeneration Giorgetti E, Obrecht M, Ronco M, Panesar M, Lambert C, Accart N, Doelemeyer A, Nash M, Bidinosti M, Beckmann N 2019 Scientific Reports Neuroscience Classifier HALO
Unmasking of oestrogen?dependent changes in left ventricular structure and function in aged female rats: a potential model for pre?heart failure with preserved ejection fraction Bustamante M, Garate?Carrillo A, Ito BR, Garcia R, Carson N, Ceballos G, Ramirez?Sanchez I, Omens J, Villarreal F 2019 The Journal of Physiology Myology Area Quantification, Layer Thickness HALO
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Glucose-Dependent Insulinotropic Polypeptide Receptor-Expressing Cells in the Hypothalamus Regulate Food Intake Adriaenssens AE, Biggs EK, Darwish T, Tadross J, Sukthankar T, Girish M, Polex-Wolf J, Lam BY, Zvetkova I, Pan W, Chiarugi D, Yeo GSH, Blouet C, Gribble FM, Reimann F 2019 Cell Metabolism Metabolism ISH/FISH HALO
Intravital imaging reveals systemic ezrin inhibition impedes cancer cell migration and lymph node metastasis in breast cancer Ghaffari A, Hoskin V, Turashvili G, Varma S, Mewburn J, Mullins G, Greer PA, Kiefer F, Day AG, Madarnas Y, SenGupta S, Elliott BE 2019 Breast Cancer Research Oncology Classifier, Cytonuclear HALO
Modulation of Microglia by Voluntary Exercise or CSF1R Inhibition Prevents Age-Related Loss of Functional Motor Units Giorgetti E, Panesar M, Zhang Y, Joller S, Ronco M, Obrecht M, Lambert C, Accart N, Beckmann N, Doelemeyer A, Perrot L, Fruh I, Mueller M, Pierrel E, Summermatter S, Bidinosti M, Shimshek DR, Brachat S, Nash M 2019 Cell Reports Neuroscience Classifier, Cytonuclear HALO
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Tumor Characteristics Associated with Benefit from Pembrolizumab in Advanced Non-Small Cell Lung Cancer Hu-Lieskovan S, Lisberg A, Zaretsky JM, Grogan TR, Rizvi H, Wells DK, Carroll J, Cummings A, Madrigal J, Jones B, Gukasyan J, Shintaku IP, Slamon D, Dubinett S, Goldman JW, Elashoff D, Hellmann MD, Ribas A, Garon EB 2019 Clinical Cancer Research Immuno-oncology Cytonuclear HALO
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IL-7-dependent compositional changes within the ?? T cell pool in lymph nodes during ageing lead to an unbalanced anti-tumour response Chen H-C, Eling N, Martinez-Jimenez CP, O'Brien LM, Carbonaro V, Marioni JC, Odom DT, de la Roche M 2019 EMBO Reports Oncology, Immuno-oncology ISH/FISH HALO
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Cognitive and Pathological Influences of Tau Pathology in Lewy Body Disorders Coughlin DG, Xie SX, Liang M, Williams A, Peterson C, Weintraub D, McMillan CT, Wolk DA, Akhtar RS, Hurtig H, Coslett HB, Hamilton R, Siderowf A, Duda JE, Rascovsky K, Lee EB, Lee VM-Y, Grossman M, Trojanowski JQ, Irwin DJ 2019 Annals of Neurology Neuroscience Classifier, Area Quantification HALO
CCN3/Nephroblastoma Overexpressed Is a Functional Mediator of Prostate Cancer Bone Metastasis That Is Associated with Poor Patient Prognosis Dankner M, Ouellet V, Communal L, Schmitt E, Perkins D, Annis MG, BarrËs V, Caron C, Mes-Masson A-M, Saad F, Siegel PM 2019 The American Journal of Pathology Oncology Area Quantification HALO
Divergent patterns of TDP?43 and tau pathologies in primary progressive aphasia Giannini LAA, Xie SX, McMillan CT, Liang M, Williams A, Jester C, Rascovsky K, Wolk DA, Ash S, Lee EB, Trojanowski JQ, Grossman M, Irwin DJ 2019 Annals of Neurology Neuroscience Area Quantification HALO
Characterization of novel conformation-selective ?-synuclein antibodies as potential immunotherapeutic agents for Parkinson's disease Henderson MX, Covell DJ, Chung C-HY, Pitkin RM, Sandler RM, Decker SC, Riddle DM, Zhang B, Gathagan RJ, James MJ, Trojanowski JQ, Brunden KR, Lee VMY, Luk KC 2019 Neurobiology of Disease Neuroscience Area Quantification HALO
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IRAK4 mediates colitis-induced tumorigenesis and chemoresistance in colorectal cancer Li Q, Chen Y, Zhang D, Grossman J, Li L, Khurana N, Jiang H, Grierson PM, Herndon J, DeNardo DG, Challen GA, Liu J, Ruzinova MB, Fields RC, Lim K-H 2019 JCI Insight Oncology, Immuno-oncology Area Quantification HALO
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Exposure to maternal obesity programs sex differences in pancreatic islets of the offspring in mice Nicholas LM, Nagao M, Kusinski LC, Fernandez-Twinn DS, Eliasson L, Ozanne SE 2019 Diabetologia Metabolism Area Quantification HALO
Histological characterization of aldosterone-producing adrenocortical adenomas with different somatic mutations Ono Y, Yamazaki Y, Omata K, Else T, Tomlins SA, Rhayem Y, Williams TA, Reincke M, Carling T, Monticone S, Mulatero P, Beuschlein F, Ito S, Satoh F, Rainey WE, Sasano H 2019 The Journal of Clinical Endocrinology & Metabolism Oncology Classifier, Area Quantification HALO
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Multiplexed Immunohistochemistry for Molecular and Immune Profiling in Lung CancerǃÓJust About
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Quantification of histopathological findings using a novel image analysis platform Horai Y, Mizukawa M, Nishina H, Nishikawa S, Ono Y, Takemoto K, Baba N 2019 Journal of Toxicologic Pathology Toxicology Classifier HALO
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Machine learning approaches for pathologic diagnosis Komura D, Ishikawa S 2019 Vichows Archiv Review Classifier HALO AI
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Detection of Lung Cancer Lymph Node Metastases from Whole-Slide Histopathologic Images Using a Two-Step Deep Learning Approach Pham HHN, Futakuchi M, Bychkov A, Furukawa T, Kuroda K, Fukuoka J 2019 The American Journal of Pathology Oncology Classifier HALO AI
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Automated Computational Detection, Quantitation, and Mapping of Mitosis in WholeǃÎSlide Images for Clinically Actionable Surgical Pathology Decision Support Puri M, Hoover S, Hewitt S, Wei B-R, Adissu H, Halsey C, Beck J, Bradley C, Cramer S, Durham A, Esplin D, Frank C, Lyle L, McGill L, Sanchez M, Schaffer P, Traslavina R, Buza E, Yang H, Lee M, Dwyer J, Simpson R 2019 Journal of Pathology Informatics Oncology Cytonuclear HALO
Lamin?B1 is a senescence?associated biomarker in clear?cell renal cell carcinoma Radspieler M, Schindeldecker M, Stenzel P, FÀÜrsc S, Tagscherer K, Herpel E, Hohenfellner M, Hatiboglu G, Roth W, Macher?Goeppinger S 2019 Oncology Letters Oncology Cytonuclear HALO
Upper tract urothelial carcinoma has a luminal-papillary T-cell depleted contexture and activated FGFR3 signaling Robinson BD, Vlachostergios PJ, Bhinder B, Liu W, Li K, Moss TJ, Bareja R, Park K, Tavassoli P, Cyrta J, Tagawa ST, Nanus DM, Beltran H, Molina AM, Khani F, Miguel Mosquera J, Xylinas E, Shariat SF, Scherr DS, Rubin MA, Lerner SP, Matin SF, Elemento O, Faltas BM 2019 Nature Communications Oncology, Immuno-oncology Cytonuclear HALO
IL?36 receptor antagonistic antibodies inhibit inflammatory responses in preclinical models of psoriasiform dermatitis Su Z, Paulsboe S, Wetter J, Salte K, Kannan A, Mathew S, Horowitz A, Gerstein C, Namovic M, Todorovi? V, Seagal J, Edelmayer RM, Viner M, Rinaldi L, Zhou L, Leys L, Huang S, Wang L, Sadhukhan R, Honore P, McGaraughty S, Scott VE 2019 Experimental Dermatology Dermatology Area Quantification, Cytonuclear HALO
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IL?1? cleavage by inflammatory caspases of the noncanonical inflammasome controls the senescence?associated secretory phenotype Wiggins KA, Parry AJ, Cassidy LD, Humphry M, Webster SJ, Goodall JC, Narita M, Clarke MCH 2019 Aging Cell Immunology Cytonuclear HALO
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Reduction of Global H3K27me3 Enhances HER2/ErbB2 Targeted Therapy Hirukawa A, Singh S, Wang J, Rennhack JP, Swiatnicki M, Sanguin-Gendreau V, Zuo D, Daldoul K, Lavoie C, Park M, Andrechek ER, Westbrook TF, Harris LN, Varadan V, Smith HW, Muller WJ 2019 Cell Reports Oncology Highplex FL HALO
Macrophage-Derived CXCL9 and CXCL10 Are Required
for Antitumor Immune Responses Following Immune
Checkpoint Blockade
House IG, Savas P, Lai J, Chen AXY, Oliver AJ, Teo ZL, Todd KL, Henderson MA, Giuffrida L, Petley EV, Sek K, Mardiana S, Gide TN, Quek C, Scolyer RA, Long GV, Wilmott JS, Loi S, Darcy PK, Beavis PA 2019 Clinical Cancer Research Immuno-oncology Highplex FL HALO
A single dose of neoadjuvant PD-1 blockade predicts clinical outcomes in resectable melanoma Huang AC, Orlowski RJ, Xu X, Mick R, George SM, Yan PK, Manne S, Kraya AA, Wubbenhorst B, Dorfman L, DíAndrea K, Wenz BM, Liu S, Chilukuri L, Kozlov A, Carberry M, Giles L, Kier MW, Quagliarello F, McGettigan S, Kreider K, Annamalai L, Zhao Q, Mogg R, Xu W, Blumenschein WM, Yearley JH, Linette GP, Amaravadi RK, Schuchter LM, Herati RS, Bengsch B, Nathanson KL, Farwell MD, Karakousis GC, Wherry EJ, Mitchell TC 2019 Nature Medicine Oncology, Immuno-oncology Highplex FL HALO
CXCR3 enables recruitment and site-specific bystander activation of memory CD8+ T cells Maurice NJ, McElrath MJ, Andersen-Nissen E, Frahm N, Prlic M 2019 Nature Communications Immunology Highplex FL HALO
Development of resistance to FAK inhibition in pancreatic cancer is linked to stromal depletion Jiang H, Liu X, Knolhoff BL, Hegde S, Lee KB, Jiang H, Fields RC, Pachter JA, Lim K-H, DeNardo DG 2019 Gut Oncology Cytonuclear, ISH/FISH HALO
Single-Cell Quantification of mRNA Expression in The Human Brain Jolly S, Lang V, Koelzer VH, Frigerio CS, Magno L, Salinas PC, Whiting P, Palomer E 2019 Scientific Reports Neuroscience ISH/FISH HALO
The Fat Mass and Obesity-Associated Protein (FTO) Regulates Locomotor Responses to Novelty via D2R Medium Spiny Neurons Ruud J, Alber J, Tokarska A, Engstrˆm Ruu L, Nolte H, Biglari N, Lippert R, Lautenschlager ƒ, Cie?lak PE, Szumiec ?, Hess ME, Brˆnneke HS, Kr¸ger M, Nissbrandt H, Korotkova T, Silberberg G, Rodriguez Parkitna J, Br¸ning J 2019 Cell Reports Neuroscience, Metabolism ISH/FISH HALO
Quantitative digital pathology reveals association of cell-specific PNPLA3 transcription with NAFLD disease activity Sandhu B, Perez Matos MC, Tran S, Zhong A, Csizmadia E, Kim M, Herman MA, Nasser I, Lai M, Jiang ZG 2019 JHEP Reports Fibrosis ISH/FISH HALO
Alpha-synuclein is a DNA binding protein that modulates DNA repair with implications for Lewy body disorders Schaser AJ, Osterberg VR, Dent SE, Stackhouse TL, Wakeham CM, Boutros SW, Weston LJ, Owen N, Weissman TA, Luna E, Raber J, Luk KC, McCullough AK, Woltjer RL, Unni VK 2019 Scientific Reports Neuroscience ISH/FISH HALO
Small Molecule IL-36? Antagonist as a Novel Therapeutic Approach for Plaque Psoriasis Todorovi? V, Su Z, Putman CB, Kakavas SJ, Salte KM, McDonald HA, Wetter JB, Paulsboe SE, Sun Q, Gerstein CE, Medina L, Sielaff B, Sadhukhan R, Stockmann H, Richardson PL, Qiu W, Argiriadi MA, Henry RF, Herold JM, Shotwell JB, McGaraughty SP, Honore P, Gopalakrishnan SM, Sun CC, Scott VE 2019 Scientific Reports Immunology, Dermatology ISH/FISH HALO
Changes in epidermal morphology associated with dandruff Pople JE, Bhogal RK, Moore AE, Jenkins G 2019 International Journal of Cosmetic Science Dermatology Cytonuclear, Layer Thickness HALO
PD-L1 Expression and Clinical Outcomes to Cabozantinib, Everolimus, and Sunitinib in Patients with Metastatic Renal Cell Carcinoma: Analysis of the Randomized Clinical Trials METEOR and CABOSUN Flaifel A, Xie W, Braun DA, Ficial M, Bakouny Z, Nassar AH, Jennings RB, Escudier B, George DJ, Motzer RJ, Morris MJ, Powles, Wang E, Huang Y, Freeman GJ, Choueiri TK, Signoretti S 2019 Clinical Cancer Research Immuno-oncology Multiplex IHC HALO
The KDM5A/RBP2 histone demethylase represses NOTCH signaling to sustain neuroendocrine differentiation and promote small cell lung cancer tumorigenesis Oser MG, Sabet AH, Gao W, Chakraborty AA, Schinzel AC, Jennings RB, Fonseca R, Bonal DM, Booker MA, Flaifel A, Novak JS, Christensen VL, Zhang H, Herbert ZT, Tolstorukov MY, Buss EJ, Wong K-K, Bronson RT, Nguyen Q-D, Signoretti S, Kaelin Jr WG 2019 Genes & Development Oncology Multiplex IHC HALO
Physiologic serum 1,25 dihydroxyvitamin D is inversely associated with prostatic Ki67 staining in a diverse sample of radical prostatectomy patients Rosenberg A, NetteY OS, Gogana P, Sheikh U, Virgilia M, Macias V, Kajdacsy-Balla A, R Sharifi R, Kittles RA, Murphy AB 2019 Cancer Causes & Control Oncology Multiplex IHC HALO
Nuclear Glycogenolysis Modulates Histone Acetylation in Human Non-Small Cell Lung Cancers Sun RC, Dukhande VV, Zhou Z, Young LEA, Emanuelle S, Brainson CF, Gentry MS 2019 Cell Metabolism Oncology Multiplex IHC HALO
Inducing and exploiting vulnerabilities for the treatment of liver cancer Wang C, Vegna S, Jin H, Benedict B, Lieftink C, Ramirez C, de Oliveira RL, Morris B, Gadiot J, Wang W, du Chatinier A, Wang L, Gao D, Evers B, Jin G, Xue Z, Schepers A, Jochems F, Sanchez AM, Mainardi S, te Riele H, Beijersbergen RL, Qin W, Akkari L, Bernards R 2019 Nature Oncology Multiplex IHC HALO
Neoadjuvant anti-PD-1 immunotherapy promotes a survival benefit with intratumoral and systemic immune responses in recurrent glioblastoma Cloughesy TF, Mochizuki AY, Orpilla JR, Hugo W, Lee AH, Davidson TB, Wang AC, Ellingson BM, Rytlewski JA, Sanders CM, Kawaguchi ES, Du L, Li G, Yong WH, Gaffey SC, Cohen AL, Mellinghoff IK, Lee EQ, Reardon DA, OíBrien BJ, Butowski NA, Nghiemphu PL, Clarke JL, Arrillaga-Romany IC, Colman H, Kaley TJ, de Groot JF, Liau LM, Wen PY, Prins RM 2019 Nature Medicine Oncology, Immuno-oncology Spatial Analysis, Highplex FL HALO
PAK4 inhibition improves PD-1 blockade immunotherapy Abril-Rodriguez G, Torrejon DY, Liu W, Zaretsky JM, Nowick TS, Tsoi J, Puig-Saus C, Baselga-Carretero I, Medina E, Quist MJ, Garcia AJ, Senapedis W, Baloglu E, Kalbasi A, Cheung-Lau G, Berent-Maoz B, Comin-Anduix B, Hu-Lieskovan S, Wang C-Y, Grasso CS, Ribas A 2019 Nature Cancer Immuno-oncology HALO
Histological characterization of aldosterone-producing adrenocortical adenomas with different somatic mutations Acosta-Ruiz A, Gutzeit VA, Skelly MJ, Meadows S, Lee J, Parekh P, Orr AG, Liston C, Pleil KE, Broichhagan J, Levitz J 2019 Neuron Neuroscience HALO
Amyloid-Beta (A?) Plaques Promote Seeding and Spreading of Alpha-Synuclein and Tau in a Mouse Model of Lewy Body Disorders with A? Pathology Bassil F, Brown HJ, Pattabhiraman S, Iwasyk JE, Maghames CM, Meymand ES, Cox TO, Riddle FM, BinZhang N, Trojanowski JQ, Lee VM-Y 2019 Neuron Neuroscience HALO
Rabbit monoclonal E?cadherin antibody: A cost?effective alternative to mouse monoclonal antibody in distinguishing ductal carcinoma in situ from lobular carcinoma in situ Baum JE, Croyle JA, Brodsky VB, Liu Y, Shin SJ 2019 The Breast Journal Oncology Cytonuclear HALO
MAPKAPK2 (MK2) inhibition mediates radiation-induced inflammatory cytokine production and tumor growth in head and neck squamous cell carcinoma Berggren KL, Cruz SR, Hixon MD, Cowan AT, Keysar SB, Craig S, James J, Barry M, Ozbun MA, Jimeno A, McCance DJ, Beswick EJ, Gan GN 2019 Oncogene Oncology Cytonuclear, Figure Maker HALO
Pre-diagnostic anthropometry, sex, and risk of colorectal cancer according to tumor immune cell composition Berntsson J, Eberhard J, Nodin B, Leandersson K, Larsson AH, Eberhard J, Jirstrom K 2019 OncoImmunology Immuno-oncology HALO
Single cell transcriptomic profiling of large intestinal enteroendocrine cells in mice - Identification of selective stimuli for insulin-like peptide-5 and glucagon-like peptide-1 co-expressing cells Billing LJ, Larraufie P, Lewis J, Leiter A, Li J, Lam B, Yeo GSH, Goldspink DA, Kay RG, Gribble FM, Reimann F 2019 Molecular Metabolism Metabolism HALO
Genetic mutations underlying phenotypic plasticity in basosquamous carcinoma Chiang A, Tan CZ, Kuonen F, Hodgkinson LM, Chiang F, Cho RJ, South AP, Tang Jean Y, Chang ALS, Rieger KE, Oro AE, Sarin KY 2019 Journal of Investigative Dermatology Oncology Cytonuclear HALO
Kras and Lkb1 mutations synergistically induce intraductal papillary mucinous neoplasm derived from pancreatic duct cells Collet L, Ghurburrun E, Meyers N, Assi M, Pirlot B, Leclercq IA, Couvelard A, Komuta M, Cros J, Demetter P, Lemaigre FP, Borbath I, Jacquemin P 2019 Gut Oncology HALO
Next-generation computational tools for interrogating cancer immunity Finotello F, Rieder D, Hackl H, Trajanoski Z 2019 Nature Reviews Genetics Review HALO
The crosstalk between aldosterone and calcium metabolism in primary aldosteronism: A possible calcium metabolism-associated aberrant ìneoplasticî steroidogenesis in adrenals Gao X, Yamazaki Y, Tezuka Y, Onodera Y, Ogata H, Omata K, Morimoto R, Nakamura Y, Satoh F, Sasano H 2019 The Journal of Steroid Biochemistry and Molecular Biology Oncology, Metabolism Cytonuclear HALO
Farnesoid X Receptor Agonism, AcetylCoenzyme A Carboxylase Inhibition, and Back Translation of Clinically Observed Endpoints of De Novo Lipogenesis in a Murine NASH Model Gapp B, Jourdain M, Bringer P, Kueng B, Weber D, Osmont A, Zurbruegg S, Knehr J, Falchetto R, Roma G, Dietrich W, Valdez R, Beckmann N, Nigsch F, Sanyal AJ, Ksiazek I 2019 Hepatology Communications Metabolism Cytonuclear HALO
Open radial artery harvesting better preserves endothelial function compared to the endoscopic approach Gaudino MF, Lorusso R, Ohmes LB, Narula N, McIntire PJ, Gargiulo A, Bucci MR, Leonard J, Rahouma M, Di Franco A, He GW, Girardi LN, Tranbaugh RF, Di Lorenzo A 2019 Interactive CardioVascular and Thoracic Surgery HALO
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Oral tenofovir disoproxil fumarate/emtricitabine for HIV pre-exposure prophylaxis increases expression of type I/III interferon-stimulated factors in the gastrointestinal tract but not in the blood Hughes SM, Levy CN, Calienes F, Stekler JD, Pandey U, Vojtech L, Berard AR, Birse K, Noel-Romas L, Richardson B, Golden J, Cartwright M, Collier AC, Stevens CE, Curlin ME, Holtz TH, Mugo N, Irungu E, Katabira E, Muwonge T, Lama JR, Baeten JM, Burgener A, Lingappa JR, McElrath MJ, Mackelprang R, McGowan I, Cranston RD, Cameron MJ, Hladik F 2019 bioRxiv Infectious Disease Cytonuclear HALO
Intraintestinal and Parenteral Administration of an Insulin Analogue Leads to Comparable Activation of Signaling Downstream of the Insulin Receptor in the Small Intestine Hvid H, Kildegaard J, Kristensen K, Porsgaard T, J¯rgensen MS, BallarÌn-Gonz·lez B, Ahnfelt-R¯nne J, Hansen Bo F, Nishimura E 2019 Journal of Diabetes Science and Technology Metabolism HALO
Epithelial NOTCH Signaling Rewires the Tumor Microenvironment of Colorectal Cancer to Drive Poor-Prognosis Subtypes and Metastasis Jackstadt R, van Hooff ST, Leach JD, Cortes-Lavaud X, Lohuis JO, Ridgway RA, Wouters VM, JatinRoper J, Kendall TJ, Roxburgh CS, Horgan PG, Nixon C, Nourse C, Gunzer M, Clark W, Hedley A, Yilmaz OH, Rashid M, Bailey P, Biankin AV, Campbell AD, Adams DJ, Barry ST, Steele CW, Medema JP, Sansom OJ 2019 Cancer Cell Oncology HALO
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Lenvatinib plus anti-PD-1 antibody combination treatment activates CD8+ T cells through reduction of tumor-associated macrophage and activation of the interferon pathway Kato Y, Tabata K, Kimura T, Yachie-Kinoshita A, Ozawa Y, Yamada K, Ito J, Tachino S, Hori Y, Matsuki M, Matsuoka Y, Ghosh S, Kitano H, Nomoto K, Matsui J, Funahashi Y 2019 PLOS One Immuno-oncology HALO
Calpain 9 as a therapeutic target in TGF?-induced mesenchymal transition and fibrosis Kim DH, Beckett JD, Nagpal V, Seman-Senderos MA, Gould Russell A, Creamer TJ, MacFarlane EG, Chen Y, Bedja D, Butcher JT, Mitzner W, Rouf R, Hata S, Warren DS, Dietz HC 2019 Science Translational Medicine Fibrosis HALO
Delayed Azithromycin Treatment Improves Recovery After Mouse Spinal Cord Injury Kopper TJ, McFarlane KE, Bailey WM, Orr MB, Zhang B, Gensel JC 2019 Frontiers in Ceullar Neuroscience Neuroscience HALO
Long-Term Persistence of Anti-HIV Broadly Neutralizing Antibody-Secreting Hematopoietic Cells in Humanized Mice Kuhlmann A-S, Haworth KG, Barber-Axthelm IM, Ironside C, Giese MA, Peterson CW, Kiem H-P 2019 Molecular Therapy Infectious Disease HALO
Temporal Analysis of Amylase Expression in Control, Autoantibody Positive, and Type 1 Diabetes Pancreatic Tissues Kusmartseva I, Beery M, Hiller H, Padilla M, Selman S, Posgai A, Nick HS, Campbell-Thompson M, Schatz DA, Haller MJ, Wasserfall CH, Atkinson MA 2019 Diabetes Metabolism HALO
Phosphorylation of connexin 43 at MAPK, PKC or CK1 sites each distinctly alter the kinetics of epidermal wound repair Lastwika JK, Dunn CA, Solan JL, Lampe PD 2019 Journal of Cell Science HALO
Active Cushing's Disease is Characterized by Increased Adipose Tissue Macrophage Presence Lee IT, Atuahene A, Egritag HE, Buettner C, Wang L, Geer EB, Donovan M 2019 The Journal of Clinical Endocrinology & Metabolism Metabolism HALO
Impact of a Pre-Operative Exercise Intervention on Breast Cancer Proliferation and Gene Expression: Results from the Pre-Operative Health and Body (PreHAB) Study Ligibel JA, Dillon D, Giobbie-Hurder A, McTiernan A, Frank E, Cornwell M, Pun M, Campbell N, Dowling RJO, Chang MC, Tolaney S, Chagpar AB, Yung RL, Freedman RA, Dominici LS, Golshan M, Rhei E, Taneja K, Huang Y, Brown M, Winer EP, Jeselsohn R, Irwin ML 2019 Clinical Cancer Research HALO
A phase 2 study of GVAX colon vaccine with cyclophosphamide and pembrolizumab in patients with mismatch repair proficient advanced colorectal cancer Yarchoan M, Huang C-Y, Zhu Q, Ferguson AK, Durham JN, Anders RA, Thompson ED, Rozich NS, Thomas DL, Nauroth JM, Rodriguez C, Osipov A, De Jesus-Acosta A, Le DT, Murphy AG, Laheru D, Donehower RC, Jaffee EM, Zheng L, Azad NS 2019 Cancer Medicine Immuno-oncology Area Quantification, Partitions (tiles, margins) HALO
Hotspot enumeration of CD8+ tumor infiltrating lymphocyte using digital image analysis in triple negative breast Cancer yields consistent results McIntire PJ, Zhong E, Patel A, Khani F, D'Alfonso T, Chen Z, Shin SJ, Ginter PS 2019 Human Pathology Oncology Cytonuclear HALO
Female-biased embryonic death from inflammation induced by genomic instability McNairn AJ, Chuang C-H, Bloom JC, Wallace MD, Schimenti JC 2019 Nature Immunology Cytonuclear HALO
Imaging CAR T cell therapy with PSMA-targeted positron emission tomography Minn I, Huss DJ, Ahn H-H, Chinn TM, Park A, Jones J, Brummet M, Rowe SP, Sysa-Shah P, Du Y, Levitsky HI, Pomper MG 2019 Science Advances Oncology Cytonuclear HALO
Reliable identification of prostate cancer using mass spectrometry metabolomic imaging in needle core biopsies Morse N, Jamaspishvili T, Simon D, Patel PG, Ren KYM, Wang J, Oleschuk R, Kaufmann M, Gooding RJ, Berman DM 2019 Laboratory Invesigations Oncology HALO
Efficacy of ruthenium coordination complex-based
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HIF-independent synthetic lethality between CDK4/6 inhibition and VHL loss across species Nicholson HE, Tariq Z, Housden BE, Jennings RB, Stransky LA, Perrimon N, Signoretti S, Kaelin WG 2019 Cancer Therapy HALO
Prohibitin is a prognostic marker of relapse and therapeutic target to block chemotherapy resistance in Wilms tumor Ortiz MV, Ahmed S, Burns M, Henssen AG, Hollmann TJ, MacArthur I, Gunasekera S, Gaewsky L, Bradwin G, Ryan J, Letai A, He Y, Naranjo A, Chi Y-Y, LaQuaglia M, Heaton T, Cifani P, Dome JS, Gadd S, Perlman E, Mullen E, Steen H, Kentsis A 2019 JCI Insight Oncology Cytonuclear HALO
Validation and characterisation of prognostically significant PD-L1+ immune cells in HPV+ oropharyngeal squamous cell carcinoma Young RJ, Bressel M, Porceddu S, Cernelc J, Savas P, Liu H, Urban D, Thai AA, Cooper C, Fua T, Neeson P, Rischin D, Solomon B 2019 Oral Oncology Oncology, Infectious Disease Classifier, Highplex FL HALO
Human 3D Gastrointestinal Microtissue Barrier
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PTEN loss in Gleason grade 7 prostate tumors exhibits intratumoral heterogeneity and is associated with unfavorable pathological features PicanÁo-Albuquerque CG, Vidotto T, Pereira CS, Saggioro FP, Jamaspishvili T, Koti M, Berman DM, Squire JA, Reis RB 2019 Applied Cancer Research Oncology HALO
Extramammary Paget disease shows differential expression of B7 family members B7-H3, B7-H4, PD-L1, PD-L2 and cancer/testis antigens NY-ESO-1 and MAGE-A Pourmaleki M, Young JH, Socci ND, Chiang S, Edelweiss M, Li Y, Zhang M, Roshal L, Chi DS, Busam KJ, Mellinghoff IK, Hollmann TJ 2019 Oncotarget HALO
Impact of TREM2 risk variants on brain region-specific immune activation and plaque microenvironment in Alzheimer's disease patient brain samples Prokop S, Miller KR, Labra SR, Pitkin RM, Hoxha K, Narasimhan S, Changolkar L, Rosenbloom A, Lee VM-Y, Trojanowski JQ 2019 Acta Neuropathologica Neuroscience HALO
Delta-like protein 3 expression and therapeutic targeting in neuroendocrine prostate cancer Puca L, Gavyert K, Sailer V, Conteduca V, Dardenne E, Sigouros M, Isse K, Kearney M, Vosoughi A, Fernandez L, Pan H, Motanagh S, Hess J, Donoghue AJ, Sboner A, Wang Y, Dittamore R, Rickman D, Nanus DM, Tagawa ST, Elemento O, Mosquera JM, Saunders L, Beltran H 2019 Science Translational Medicine Oncology HALO
Mitogenic and progenitor gene programmes in single pilocytic astrocytoma cells Reitman ZJ, Paolella BR, Bergthold G, Pelton K, Becker S, Jones R, Sinai CE, Malkin H, Huang Y, Grimmet L, Herbert ZT, Sun Y, Weatherbee JL, Alberta JA, Daley JF, Rozenblatt-Rosen O, Condurat AL, Qian K, Khadka P, Segal RA, Haas-Kogan D, Filbin MG,
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Pre-exposure prophylaxis differentially alters circulating and mucosal immune cell activation in herpes simplex virus type 2 seropositive women Richert-Spuhler LE, Pattacini L, Plews M, Irungu E, Muwonge TR, Katabira E, Mugo N, Meyers AFA, Celum C, Baeten JM, Lingappa JR, Lund JM 2019 AIDS Infectious Disease HALO
A MYCñGCN2ñeIF2? negative feedback loop limits protein synthesis to prevent MYC-dependent apoptosis in colorectal cancer Schmidt S, Gay D, Uthe FW, Denk S, Paauwe M, Matthes N, Diefenbacher ME, Bryson S, Warrander FC, Erhard F, Ade CP, Baluapuri A, Walz S, Jackstadt R, Ford C, Vlachogiannis G, Valeri N, Otto C, Sch¸lein-Vˆlk C, Maurus K, Schmitz W, Knight JRP, Wolf E, Strathdee D, Schulze A, Germer C-T, Rosenwald A, Sansom OJ, Eilers M 2019 Nature Cell Biology Oncology HALO
Mobilization of CD8+ T cells via CXCR4 blockade facilitates PD-1 checkpoint therapy in human pancreatic cancer Seo YD, Jiang X, Sullivan KM, Jalikis FG, Smythe KS, Abbasi A, Vignali M, Park JO, Daniel SK, Pollack SM, Kim TS, Yeung R, Crispe IN, Pierce RH, Robins H, Pillarisetty VG 2019 Clinical Cancer Research Immuno-oncology HALO
Targeting glutamate metabolism in melanoma Singh S, Shah R, Chen S, Filipp FV 2019 arXiv HALO
Logic-Gated ROR1 Chimeric Antigen Receptor Expression Rescues T Cell-Mediated Toxicity to Normal Tissues and Enables Selective Tumor Targeting Srivastava S, Salter A, Liggitt D, Yechan-Gunja S, Sarvothama M, Cooper K, Smythe KS, Dudakov JA, Pierce RH, Rader C, Riddell SR 2019 Cancer Cell Oncology, Immuno-oncology HALO
Citrullination of fibronectin alters integrin clustering and focal adhesion stability promoting stromal cell invasion Stefanelli VL, Choudhury S, Hu P, Liu Y, Schwenzer A, Yeh C-R, Chambers DM, Pesson K, Li W, Segura T, Midwood KS, Torres M, Barker TH 2019 Matrix Biology Oncology, Fibrosis HALO
A Short Isoform of Coagulation Factor XII mRNA Is Expressed by Neurons in the Human Brainl Zamolodchikov D, Bai Y, Tang Y, McWhirter JR, Macdonald LE, Alessandri-Haber N 2019 Neuroscience Neuroscience Figure Maker HALO
Automated macrophage counting in DLBCL tissue samples: a ROF filter based approach Wagner M, Hansel R, Reinke S, Richter J, Altenbuchinger M, Braumann U-D, Spang R, Loffler Mk Klapper W 2019 Biological Proectures Online Oncology Object Colocalization HALO
Impact of pre?therapy glioblastoma multiforme microenvironment on clinical response to autologous CMV?specific T?cell therapy Walker DG, Shakya R, Morrison B, Neller MA, Matthews KK, Nicholls J, Smith C, Khanna R 2019 Clinical & Translational Immunology Immuno-oncology Classifier HALO
Human pseudoislet system enables detection of differences in G-protein-coupledreceptor signaling pathways between ? and ? cells Walker JT, Haliyur R, Nelson HA, Ishahak M, Poffenberger G, Aramandla R, Reihsmann C, Luchsinger JR, Saunders DC, Wang P, Garcia-Ocana A, Bottino R, Agarwal A, Powers AC, Brissove M 2019 bioRxiv HALO
Multiplex Immunofluorescence of Bone Marrow Core Biopsies: Visualizing the Bone Marrow Immune Contexture Walters DK, Jelinek DF 2019 Journal of Histochemistry & Cytochemistry HALO
No Evidence of Neurogenesis in Adult Rat Sympathetic Ganglia Following Guanethidine-Induced Neuronal Loss Walters KM, Boucher M, Boucher GG, Opsahl AC, Mouton PR, Liu C-N, Ritenour CR, Kawabe TT, Pryski HN, Somps CJ 2019 Toxicologic Pathology Toxicology, Neuroscience HALO
ATDC is required for the initiation of KRAS-induced pancreatic tumorigenesis Wang L, Yang H, Zamperone A, Diolaiti D, Palmbos PL, Abel EV, Purohit V, Dolgalev I, Rhim AD, Ljungman M, Hadju CH, Halbrook CJ, Bar-Sagi D, di Magliano MP, Crawford HC, Simeone DM 2019 Genes & Development Oncology HALO
Monocytes/Macrophages play a pathogenic role in IL-23 mediated psoriasis-like skin inflammation Wang Y, Edelmayer R, Wetter J, Salte K, Gauvin D, Leys L, Paulsboe S, Su Z, Weinberg I, Namovic M, Gauld SB, Honore P, Scott VE, McGaraughty S 2019 Scientific Reports Immunology, Dermatology HALO
Myeloid Cell-Derived HB-EGF Drives Tissue Recovery After Pancreatitis Wen H-J, Gao S, Wang Y, Ray M, Magnuson MA, Wright CVE, Di Magliano MP, Frankel TL, Crawford HC 2019 Cellular and Molecular Gastroenterology and Hepatology Immunology HALO
Nrf2 represses the onset of type 1 diabetes in non-obese diabetic mice Yagishita Y, Uruno A, Chartoumpekis DV, Kensler TW, Yamamoto M 2019 The Journal of Endocrinology Metabolism HALO
Systemic mRNA Therapy for the Treatment of Fabry Disease: Preclinical Studies in Wild-Type Mice, Fabry Mouse Model, and Wild-Type Non-human Primates Zhu S, Li S, Escuin-Ordinas H, Dimatteo R, Xia W, Ribas A, Segura T 2019 The American Journal of Human Genetics Metabolism HALO
Selective modulation of the androgen receptor AF2 domain rescues degeneration in spinal bulbar muscular atrophy Badders NM, Korff A, Miranda HC, Vuppala PK, Smith RB, Winborn BJ, Quemin ER, Sopher BL, Dearman J, Messing J, Kim NC, Moore J, Freibaum BD, Kanagaraj AP, Fan B, Tillman H, Chen P-C, Wang Y, Freeman BB, Li Y, Kim HJ, La Spada AR, Taylor JP 2018 Nature Medicine Myology Area Quantification HALO
Anti-NKG2A mAb Is a Checkpoint Inhibitor that Promotes Anti-tumor Immunity by Unleashing Both T and NK Cells Andre ?P, Denis C, Soulas C, Bourbon-Caillet C, Lopez J, Arnoux T, Ble?ry M, Bonnafous C, Gauthier L, Morel A, Rossi B, Remark R, Breso V, Bonnet E, Habif G, Guia S, Lalanne AI, Hoffmann C, Lantz O, Fayette J, Boyer-Chammard A, Zerbib R, Dodion P, Ghadially H, Jure-Kunkel M, Morel Y, Herbst R, Narni-Mancinelli E, Cohen RB, Vivier E 2018 Cell Oncology, Immuno-oncology Area Quantification, Cytonuclear HALO
Tuning of delta-protocadherin adhesion through combinatorial Bisogni AJ, Ghazanfar S, Williams EO, Marsh HM, Yang JYH, Lin DM 2018 eLife Neuroscience Area Quantification HALO
RAD51 foci as a functional biomarker of homologous recombination repair and PARP inhibitor resistance in germline BRCA mutated breast cancer Cruz C, Castroviejo-Bermejo M, GutiÈrrez-EnrÌquez S, Llop-Guevara A, Ibrahim YH, Gris-Oliver A, Bonache S, Morancho B, Bruna A, Rueda OM, Lai Z, Polanska UM, Jones GN,Kristel P, de Bustos L, Guzman M, Rodriguez O, Grueso J, Montalban G, Carat˙ G, Mancuso F, Fasani R, JimÈnez J, Howat WJ, Dougherty B, Vivancos A, Nuciforo P, Serres-CrÈixams X, Rubio IT, Oaknin A, Cadogan O, Barrett JC, Caldas C, Baselga J, Saura C, CortÈs J, Arribas J, Jonkers J, DÌez O, OíConnor MJ, BalmaÒa J, SerraV 2018 Annals of Oncology Oncology Classifier, Cytonuclear HALO
The brain-penetrant clinical ATM inhibitor AZD1390 radiosensitizes and improves survival of preclinical brain tumor models Durant ST, Zheng L, Wang Y, Chen K, Zhang L, Zhang T, Yang Z, Riches L, Trinidad AG, Fok JHL, Hunt T, Pike KG, Wilson J, Smith A, Colclough N, Reddy VP, Sykes A, Janefeldt A, Johnstrˆm P, Varn‰s K, Takano A, Ling S, Orme J, Stott J, Roberts C, Barrett I, Jones G, Roudier M, Pierce A, Allen J, Kahn J, Sule A, Karlin J, Cronin A, Chapman M, Valerie K, Illingworth R, Pass M 2018 Science Advances Oncology, Neuroscience Classifier, Cytonuclear HALO
High response rate to PD-1 blockade in desmoplastic melanomas Eroglu Z, Zaretsky JM, Hu-Lieskovan H, Kim DW, Algazi A, Johnson DB, Liniker E, Kong B, Munhoz R, Rapisuwon S, Gherardini PF, Chmielowski B, Wang X, Shintaku IP, Wei C, Sosman JA, Joseph RW, Postow MA, Carlino MS, Hwu W-J, Scolyer RA, Messina J, Cochran AJ, Long GV, Ribas A 2018 Nature Oncology, Immuno-oncology Cytonuclear HALO
Early Stage HER2-Positive Breast Cancers Not Achieving a pCR From Neoadjuvant Trastuzumab- or Pertuzumab-Based Regimens Have an Immunosuppressive Phenotype Force J, Howie LJ, Abbot SE, Bentley R, Marcom PK, Kimmick G, Westbrook K, Sammons SL, Parks M, Topping DL, Emerson R, Broadwater G, Hyslop T, Blackwell KL, Nair SK 2018 Clinical Breast Cancer Oncology, Immuno-oncology Cytonuclear HALO
Bortezomib prevents cytarabine resistance in MCL, which is characterized by down-regulation of dCK and up-regulation of SPIB resulting in high NF-?B activity Freiburghaus C, Emruli VK, Johansson A, Eskelund CW, Gr¯nbÊk K, Olsson R, Ek F, Jerkeman M, Ek S 2018 BMC Cancer Oncology Classifier, Cytonuclear HALO
The novel ATM inhbitior (AZ31) enhances antitumor activity in patient derived xenografts that are resistant to irinotecan montherapy Greene J, Nguyen A, Bagby SM, Jones GN, Tai WM, Quackenbush KS, Schreiber A, Messersmith WA, Devaraj KM, Blatchford P, Eckhardt SG, Cadogan EB, Hughes GD, Smith A, Pitts TM, Arcaroli JJ 2018 Oncotarget Oncology Classifier, Area Quantification, Cytonuclear HALO
Cystic fibrosisñrelated diabetes is caused by islet loss and inflammation Hart NJ, Aramandla R, Poffenberger G, Fayolle C, Thames AH, Bautista A, Spigelman AF, Babon JAB, DeNicola ME, Dadi PK, Bush WS, Balamurugan AN, Brissova M, Dai C, Prasad N, Bottino R, Jacobson DA, Drumm ML, Kent SC, MacDonald PE, Powers AC 2018 JHI Insights Immunology, Metabolism, Fibrosis Cytonuclear HALO
Attenuation of diet-induced hypotalamic inflammation following bariatric surgery in female mice Herrick MK, Favela KM, Simerly RB, Abumrad NN, Bingham NC 2018 Molecular Medicine Immunology, Neuroscience Cytonuclear HALO
pRAD50: a novel and clinically applicable pharmacodynamic biomarker of both ATM and ATR inhibition identified using mass spectrometry and immunohistochemistry Jones GN, Rooney C, Griffin N, Roudier M, Young LA, Garcia-Trinidad A, Hughes GD, Whiteaker JR, Wilson Z, Odedra R, Zhao L, Ivey RG, Howat WJ, Harrington EA, Carrett JC, Ramos-Montoya A, Lau A, Paulovich AG, Cadogan EB, Pierce AJ 2018 British Journal of Cancer Oncology Classifier, Cytonuclear HALO
Mice harboring the human SLC30A8 R138X loss-of-function mutation have increased insulin secretory capacity Kleinera S, Gomeza D, Megraa B, Naa E, Bhavsara R, Cavinoa K, Xina Y, Rojasa J, Dominguez-Gutierreza G, Zambrowicza B, Carratb G, Chabosseaub P, Hub M, Murphya AJ, Yancopoulosa GD, Rutterb GA, Gromadaa J 2018 Proceedings of the National Academy of Sciences Metabolism Cytonuclear HALO
TGF? inhibition restores a regenerative response in acute liver injury by suppressing paracrine senescence Bird TG, M¸ller M, Boulter L, Vincent DF, Ridgway RA, Elena Lopez-Guadamillas E, Lu W-Y, Jamieson T, Govaere O, Campbell AD, Ferreira-Gonzalez S, Cole AM, Hay T, Simpson KJ, Clark W, Hedley A, Clarke M, Gentaz P, Nixon C, Bryce S, Kiourtis C, Sprangers J, Nibbs RJB, Van Rooijen N, Bartholin L, McGreal SR, Apte U, Barry ST, Iredale JP, Clarke AR, Serrano M, Roskams TA, Sansom OJ, Forbes SJ 2018 Science Translational Medicine Metabolism ISH/FISH HALO
Food Perception Primes Hepatic ER Homeostasis via Melanocortin-Dependent Control of mTOR Activation Brandt C, Nolte H, Henschke S, Ruud LE, Awazawa M, Morgan DA, Gabel P, Sprenger H-G, Hess ME, G¸nther S, Langer T, Rahmouni K, Fenselau H, Kr¸ger M, Br¸ning JC 2018 Cell Neuroscience, Metabolism ISH/FISH HALO
Gene Signature of Proliferating Human Pancreatic ?-Cells Dominguez Gutierrez G, Xin Y, Okamoto H, Kim J, Lee A-H, Ni M, Adler C, Yancopoulos GD, Murphy AJ, Gromada J 2018 Endocrionology Metabolism ISH/FISH HALO
A phase II study of the dual mTOR inhibitor MLN0128 in patients with metastatic castration resistant prostate cancer Graham L, Banda K, Torres A, Carver BS, Chen Y, Pisano K, Shelkey G, Curley T, Scher HI, Lotan TL, Hsieh AC, Rathkopf DE 2018 Investigational New Drugs Oncology ISH/FISH HALO
Ultrasensitive automated RNA in situ hybridization for kappa and lambda light chain mRNA detects B-cell clonality in tissue biopsies with performance comparable or superior to flow cytometry Guo L, Wang Z, Anderson CA, Doolittle E, Kernag S, Cotta CV, Ondrejka SL, Ma X-J, Cook JR 2018 Modern Pathology Other Classifier, ISH/FISH HALO
CD163+ macrophages promote angiogenesis and vascular permeability accompanied by inflammation in atherosclerosis Guo L, Akahori H, Harari E, Smith SL, Polavarapu R, Karmali V, Otsuka F, Gannon RL, Braumann RE, Dickinson MH, Gupta A, Jenkins AL, Lipinski MJ, Kim J, Chhour P, de Vries PS, Jinnouchi H, Kutys R, Mori H, Kutyna MD, Torii S, Sakamoto A, Choi CU, Cheng Q, Grove M, Mariem A. Sawan MA, Zhang Y, Cao Y, Kolodgie FD, Cormode DP, Arking DE, Boerwinkle E, Morrison AC, Erdmann J, Sotoodehnia N, Virmani R, and Finn AV 2018 The Journal of Clinical Investigation Immunology Layer Thickness HALO
Glucagon contibutes to liver zonation Cheng X, Kim SK, Okamoto H, Xin Y, Yancopoulos GD, Murphy AJ, Gromada J 2018 Proceedings of the National Academy of Sciences Metabolism Area Quantification HALO
Evaluation of PD-L1 expression on vortex-isolated circulating tumor cells in metastatic lung cancer Dhar M, Wong J, Che J, Matsumoto M, Grogan T, Elashof D, Garon EB, Goldman JW, Christen ES, Carlo DD, Kulkarni RP 2018 Scientific Reports Oncology, Immuno-oncology Area Quantification HALO
Digital image analysis of†Ki67 proliferation index in†breast cancer using virtual dual staining on†whole tissue sections: clinical validation and†inter?platform agreement Koopman T, Buikema HJ, Hollema H, de Bock GH, van der Vegt B 2018 Breast Cancer Research and Treatment Oncology Classifier, Cytonuclear HALO
The neurotrophic tyrosine kinase receptor TrkA and its ligand NGF are increased in squamous cell carcinomas of the lung Gao F, Griffin N, Faulkner S, Rowe CW, Williams L, Roselli S, Thorne RF, Ferdoush A, Jobling P, Walker MM, Hondermarck H 2018 Scientific Reports Oncology Area Quantification HALO
Ovarian Tumor Microenvironment Signaling: Convergence on the Rac1 GTPase Hudson LG, Gillette JM, Kang H, Rivera MR, Wandinger-Ness A 2018 Cancers Review Classifier, Cytonuclear, Figure Maker HALO
A murine glaucoma model induced by rapid in vivo photopolymerization of hyaluronic acid glycidyl methacrylate Guo C, Qu X, Rangaswamy N, Leehy B, Xiang C, Rice D, Prasanna G 2018 PLOS One Biomaterials Area Quantification HALO
Systemic messenger RNA as an etiological treatment for acute intermittent porphyria Jiang L, Berraondo P, JericÛ D, Guey LT, Sampedro A, Frassetto A, Benenato KE, Burke K, SantamarÌa E, Alegre M, Pejenaute A, Kalariya M, Butcher W, Park JS, Zhu X, Sabnis S, Kumarasinghe ES, Salerno T, Kenney M, Lukacs CM, ¡vila MA, Martini PGV, Fontanellas A 2018 Nature Medicine Metabolism Area Quantification HALO
Tumor Microenvironment in Functional Adrenocortical Adenomas: Immune Cell Infiltration in Cortisol-producing Adrenocortical Adenoma Kitawaki Y, Nakamura Y, Kubota-Nakayama F, YamazakiY, Miki Y, Hata S, Ise K, Kikuchie K, MorimotoR, Satoh F, Sasano H 2018 Human Pathology Oncology, Immuno-oncology Area Quantification HALO
Up-Regulation of Iba-1 and GFAP in the Acidic Saline Model of Chronic Widespread Musculoskeletal Pain: A Pilot Study Examining the Relationship Between Gliosis and Hyperalgesia Lambert DM, Kumar U, Hafell UO 2018 Journal of Neuroscience and Neuropharmacology Neuroscience Area Quantification, Partitions (tiles, margins) HALO
Tough Composite Hydrogels with High Loading and Local Release of Biological Drugs Li J, Weber E, Guth?Gundel S, Schuleit M, Kuttler A, Halleux C, Accart N, Doelemeyer A, Basler A, Tigani B, Wuersch K, Fornaro M, Kneissel M, Stafford A, Freedman BR, Mooney DJ 2018 Advanced Healthcare Materials Biomaterials Area Quantification HALO
Blocking HIF signaling via novel inhibitors of CA9 and APE1/Ref-1 dramatically affects pancreatic cancer cell survival Logsdon DP, Fenil S, Fabrizio C, Supuran CT, Kamocka M, Jacobsen MH, Sandusky GE, Kelley MR, Fishel ML 2018 Scientific Reports Oncology Classifier, Cytonuclear HALO
Diet-Induced Growth Is Regulated via Acquired Leptin Resistance and Engages a PomcSomatostatin-Growth Hormone Circuit Lohr H, Hess S, Pereira MMA, Reino P, Leibold S, Schenkel C, Wunderlich CM, Kloppenburg P, Bruning JC, Hammerschmidt M 2018 Cell Reports Neuroscience, Metabolism Cytonuclear HALO
Chronic Intermittent Hypoxia Induces Robust Astrogliosis in an Alzheimer's Disease-Relevant Mouse Model Macheda T, Roberts K, Lyons DN, Higgins E, Ritter KJ, Lin A-L, Alilain WJ, Bachstetter AD 2018 Neuroscience Neuroscience Area Quantification HALO
Cellular milieu imparts distinct pathological ?-synuclein strains in ?-synucleinopathies Peng C, Gathagan RJ, Covell DJ, Medellin C, Stieber A, Robinson JL, Zhang B, Pitkin RM, Olufemi MF, Luk KC, Trojanowski JQ, Lee VM-Y 2018 Nature Neuroscience Area Quantification HALO
Differential ?-synuclein expression contributes to selective vulnerability of hippocampal neuron subpopulations to fibril-induced toxicity Luna E, Decker SC, Riddle DM, Caputo A, Zhang B, Cole T, Caswell C, Xie SX, Lee VMY, Luk KC 2018 Acta Neuopathologica Neuroscience Area Quantification, Cytonuclear HALO
Digital image analysis improves precision of PD?L1 scoring in cutaneous melanoma Koelzer VH, Gisler A, Hanhart JC, Griss J, Wagner SN, Willi N, Cathomas G, Sachs M, Kempf W, Thommen DS, Mertz KD 2018 Histopathology Oncology, Immuno-oncology Classifier, Multiplex IHC HALO
Lenvatinib inhibits angiogenesis and tumor fibroblast growth factor signaling pathways in human hepatocellular carcinoma models Matsuki M, Hoshi T, Yamamoto Y, Ikemori-Kawada M, Minoshima Y, Funahashi Y, Matsui J 2018 Cancer Medicine Oncology Cytonuclear HALO
Hot Spot and Whole-Tumor Enumeration of CD8(+) Tumor-Infiltrating Lymphocytes Utilizing Digital Image Analysis Is Prognostic in Triple-Negative Breast Cancer McIntire PJ, Irshaid L, Liu Y, Chen Z, Menken F, Nowak E, Shin SJ, Ginter PS 2018 Clinical Breast Cancer Oncology, Immuno-oncology Cytonuclear, Figure Maker HALO
Altered dopaminergic regulation of the dorsal striatum is able to induce tic-like movements in juvenile rats Nespoli E, Rizzo F, Boeckers T, Schulze U, Hengerer B 2018 PLOS One Neuroscience Cytonuclear HALO
Induction of†hemangiosarcoma in†mice after†chronic treatment with†S1P-modulator siponimod and†its lack of†relevance to†rat and†human Pognan F, Mahl JA, Papoutsi M, David†Ledieu D, Raccuglia M, Theil D, Voytek SB, Devine PJ, Kubek?Luck K, Claudio N, Cordier A, Heier A, Kolly C, Hartmann A, Chibout S-D, Bouchard P,†Trendelenburg C 2018 Archives of Toxicology Toxicology Classifier, Cytonuclear HALO
Intermittent Hypoxia Exacerbates Increased Blood Pressure in Rats with Chronic Kidney Disease Riggs J, Pace C, Ward HH, Gonzalez Bosc L, Rios L, Barrera A, Kanagy NL 2018 American Jornal of Physiology-Renal Physiology Metabolism Classifier, Cytonuclear HALO
Mild Impairment of Mitochondrial OXPHOS Promotes Fatty Acid Utilization in POMC Neurons and Improves Glucose Homeostasis in Obesity Timper K, Paeger L, S·nchez-Lasheras C, Varela L, Jais A, Nolte H, Vogt MC, Hausen AC, Heilinger C, Evers N, Pospisilik JA, Penninger JM, Taylor EB, Horvath TL, Kloppenburg P, Br¸ning JC 2018 Cell Repots Neuroscience, Metabolism Cytonuclear HALO
Biomarker Evaluation and Toxic Effects of an Acute Oral and Systemic Fumonisin Exposure of Pigs with a Special Focus on Dietary Fumonisin Esterase Supplementation Schertz H, Danicke S, Frahm J, Schatzmayr D, Dohnal I, Bichl G, Schwartz-Zimmerman HE, Colicchia S, Breves G, Teifke JP, Kluess J 2018 Toxins Toxicology Classifier HALO
Mutant myocilin impacts sarcomere ultrastructure in mouse gastrocnemius muscle Lynch JM, Dolman AJ, Guo C, Dolan K, Xiang C, Reda S, Li B, Prasanna G 2018 PLOS One Gastroenterology, Myology ISH/FISH HALO
Breast and pancreatic cancer interrupt IRF8-dependent dendritic cell development to overcome immune surveillance Meyer MA, Baer JM, Knolhoff BL, Nywening TM, Panni RZ, Su X, Weilbaecher KN, Hawkins WG, Ma C, Fields RC, Linehan DC, Challen GA, Faccio R, Aft RL, DeNardo DG 2018 Nature Communications Oncology, Immuno-oncology ISH/FISH HALO
What is the added value of digital image analysis of HER2 immunohistochemistry in breast cancer in clinical practice? A study with multiple platforms Koopman T, Buikema HJ, Hollema H, de Bock GH, van der Vegt B 2018 Histopathology Oncology Membrane HALO
Tumor Cell Subtypes Based on the Intracellular Hormonal Activity in KCNJ5-Mutated Aldosterone-Producing Adenoma Yamazaki Y, Omata K, Tezuka Y, Ono Y, Morimoto R, Adachi Y, Ise K, Nakamura Y, Gomez-Sanchez CE, Shibahara Y, Kitamoto T, Nishikawa T, Ito S, Satoh F, Sasano H 2018 Hypertension Oncology Area Quantification, Cytonuclear HALO
Disease Progression and Pharmacological Intervention in a Nutrient-Deficient Rat Model of Nonalcoholic Steatohepatitis T¯lb¯l KS, Stierstorfer B, Rippmann JF, Veidal SS, Rigbolt KTG, Schˆnberger T, Gillum MP, Hansen HH, Vrang N, Jelsing J, Feigh M, Broermann A 2018 Digestive Diseases and Sciences Metabolism Area Quantification HALO
FOXM1 contributes to treatment failure in acute myeloid leukemia Khan I, Halasi M, Patel A, Schultz R, Kalakota N, Chen Y-H, Aardsma N, Liu L, Crispino JD, Mahmud N, Frankfurt O, Gartel AL 2018 JCI Insight Oncology Multiplex IHC HALO
A transcriptionally and functionally distinct PD-1+ CD8+ T cell pool with predictive potential in non-small-cell lung cancer treated with PD-1 blockade Thommen DS, Koelzer VH, Herzig P, Roller A, Trefny M, Dimeloe S, Kiialainen A, Hanhart J, Schil C, Hess C, Prince SS, Wiese M, Lardinois D, Ho P-C, Klein C, Karanikas V, Mertz KD, Schumacher TN, Zippelius A 2018 Nature Medicine Oncology, Immuno-oncology Multiplex IHC HALO
Relationship between mismatch repair immunophenotype and long-term survival in patients with resected periampullary adenocarcinoma Heby M, Lundgren S, Nodin B, Elebro J, Eberhard J, JirstrÀÜm K 2018 Journal of Translational Medicine Oncology, Immuno-oncology Object Colocalization HALO
Luminally-polarized mural and vascular remodeling in ileal strictures of Crohn's Disease Zhang X, Ko HM, Torres J, Panchal HJ, Cai Z, WagneR M, Sands BE, Colombel J-F, Cho J, Taouli B, Harpaz N 2018 Human Pathology Immunology Layer Thickness HALO
Age-related pathology after adenoviral overexpression of the leucine-rich repeat kinase 2 in the mouse striatum Kritzingerab A, Ferger B, Gillardon F, Stierstorfer B, Birk G, Kochanek S, Ciossek T 2018 Neurobiology of Aging Neuroscience Area Quantification, Object Colocalization, Microglia HALO
Pharmacogenetic neuronal stimulation increases human tau pathology and trans-synaptic spread of tau to distal brain regions in mice Schultz MK, Gentzel R, Usenovic M, Gretzul C, Ware C, Parmentier-Batteur S, Schachter JB, Zariwala HA 2018 Neurobiology of Disease Neuroscience Object Colocalization HALO
Comparison of Biologic Effect and Particulate Embolization after Femoral Artery Treatment with Three Drug-Coated Balloons in Healthy Swine Model Torii S, Jinnouchi H, Sakamoto A, Romero ME, Kolodgie FD, Virmani R, Finn AV 2018 Journal of Vascular and Interventional Radiology Other Object Colocalization HALO
Multidimensional, quantitative assessment of PD-1/PD-L1 expression in patients with Merkel cell carcinoma and association with response to pembrolizumab Giraldo NA, Nguyen P, Engle EL, Kaunitz GJ, Cottrell TR, Berry S, Green B, Soni A, Cuda JD, Stein JE, Sunshine JC, Succaria F, Xu H, Ogurtsova A, Danilova L, Church CD, Miller NJ, Fling S, Lundgren L, Ramchurren N, Yearley JH, Lipson EJ, Cheever M, Anders RA, Nghiem PT, Topalian SL, Taube JM 2018 Journal for ImmunoTherapy of Cancer Oncology, Immuno-oncology Spatial Analysis, Serial Section HALO
A CD3-bispecific molecule targeting P-cadherin demonstrates T cell-mediated regression of established solid tumors in mice TS Fisher, AT Hooper, J Lucas, TH Clark, AK Rohner, B Peano, MW Elliott, K Tsaparikos, H Wang, J Golas, M Gavriil, N Haddish-Berhane, L Tchistiakova, H-P Gerber, AR Root, C May 2018 Cancer Immunology, Immunotherapy Oncology, Immuno-oncology Area Quantification HALO
Innate Sex Bias of Staphylococcus aureus Skin Infection Is Driven by a-Hemolysin Castleman MJ, Pokhrel S, Triplett KD, Kusewitt DF, Elmore BO, Joyner JA, Femling JK, Sharma G, Hathaway HJ, Prossnitz ER, Hall PR 2018 The Journal of Immunology Infectious Disease HALO
Subclonal evolution of pulmonary adenocarcinomas delineated by spatially distributed somatic mitochondrial mutations Kazdal D,†Harms A,†Endris V,†Penzel R,†Kriegsmann M,†Eichhorn F,†Muley T,†Stenzinger A,†Pfarr N,†Weichert W,†and†Warth A 2018 Lung Cancer HALO
Molecular and immunologic analysis of laryngeal squamous cell carcinoma in smokers and non-smokers Malm I-J, rooper LM, Bishop JA, Ozgursoy SK, Hillel AT, Akst LM, Best SR 2018 American Journal of Otolaryngology Oncology, Immuno-oncology HALO
Class 4 Semaphorins and Plexin-B receptors regulate GABAergic and glutamatergic synapse development in the mammalian hippocampus McDermott JE, Goldblatt D, Paradis S 2018 Molecular and Cellular Neuroscience Neuroscience HALO
Acquired cancer resistance to combination
immunotherapy from transcriptional loss
of class I HLA
Paulson KG, Voillet V, McAfee MS, Hunter DS, Wagener FD, Perdicchio, Valente WJ, Koelle SJ, Church CD, Vandeven N, Thomas H, Colunga AG, Iyer JG, Yee C, Kulikauskas R, Koelle DM, Pierce RH, Bielas JH, Greenberg PD, Bhatia S, Gottardo R, Nghiem P, Chapuis AG 2018 Nature Communications Immuno-oncology Partitions (tiles, margins), Figure Maker HALO
Digital image analysis supports a nuclear-to-cytoplasmic ratio cutoff value below 0.7 for positive for high-grade urothelial carcinoma and suspicious for high-grade urothelial carcinoma in urine cytology specimens McIntire PJ, Snow JT, Elsoukkary SS, Soong L, Sweeney J, Robinson BD, Siddiqui MT 2018 Cancer Cytopathology Oncology HALO
Ossabaw Pigs With a PCSK9 Gain?of?Function Mutation Develop Accelerated Coronary Atherosclerotic Lesions: A Novel Model for Preclinical Studies Yuan F, Guo L, Park K-H, Woollard JR, Taek?Geun K, Jiang K, Melkamu T, Zang B, Smith SL, Fahrenkrug SC, Kolodgie FD, Lerman A, Virmani R, Lerman LO, Carlson DF 2018 Journal of the American Heart Association Myology Area Quantification HALO
Accelerated wound healing by injectable star poly(ethylene)-b-poly(propylene sulfide) scaffolds loaded with poorly water-soluble drugs Zhu X, Yin L, Theisen M, Zhuo J, Siddiqui S, Levy B, Presnyak V, Frassetto A, Milton J, Salerno T, Benenato KE, Milano J, Lynn A, Sabnis S, Burke K, Besin G, Lukacs CM, Guey LT, Finn PF, Martini PGV 2018 Journal of Controlled Release Biomaterials, Wound Healing Cytonuclear HALO
The use of automated Ki67 analysis to predict Oncotype DX risk-of-recurrence categories in early-stage breast cancer Thakur SS, Li H, Chan AMY, Tudor R, Bigras G, Morris D, Enwere EK 2018 PLOS ONE Oncology Cytonuclear, Figure Maker, Partitions (tiles, margins) HALO
Inhibiting Interleukin 36 Receptor Signaling Reduces Fibrosis in Mice with Chronic Intestinal Inflammation Scheibe K, Kersten C, Schmied A, Vieth M, Primbs T, CarlÈ B, Knieling F, Claussen J, Klimowicz AC, Zheng J, Baum P, Meyer S, Sch¸rmann S, Friedrich O, Waldner MJ, Rath T, Wirtz S, Kollias G, Ekici AB, Atreya R, Raymond EL, Mbow ML, Neurath MF, Neufert C 2018 Gastroenterology Immunology, Fibrosis HALO
Low and variable tumor reactivity of the intratumoral TCR repertoire in human cancers Scheper W, Kelderman S, Fanchi LF, Linnemann C, Bendle G, de Rooij MAJ, Hirt C, Mezzadra R, Slagter M, Dijkstra K, Kluin RJC, Snaebjornsson P, Milne K, Nelson BH, Zijlmans H, Kenter G, Voest EE, Haanen JBAG, Schumacher TN 2018 Nature Medicine Oncology, Immuno-oncology Cytonuclear HALO
A suboptimal maternal diet combined with accelerated postnatal growth results in an altered aging profile in the thymus of male rats Tarry-Adkins JL, Aiken CE, Ashmore TJ, Fernandez-Twinn DS, Chen J-H, Ozanne SE 2018 The FASEB Journal Neuroscience, Metabolism Classifier, Vacuole HALO
A brain-penetrant triazolopyrimidine enhances microtubule-stability, reduces axonal dysfunction and decreases tau pathology in a mouse tauopathy model. Zhang B, Yao Y, Cornec A-S, Oukoloff K, James MJ, Koivula P, Trojanowski JQ, Smith AB III, Lee VM-Y, Ballatore C, Brunden KR 2018 Molecular Neurodegeneration Neuroscience Area Quantification HALO
GABA promotes ?-cell proliferation, but does not overcome impaired glucose homeostasis associated with diet-induced obesity Untereiner A, Abdo S, Bhattacharjee A, Gohil H, Pourasgari F, Ibeh N, Lai M, Batchuluun B, Wong A, Khuu N, Liu Y, Rijjal DA, Winegarden N, Virtanen C, Orser BA, Cabrera O, Varga G, Rocheleau J, Dai FF, Wheeler MB 2018 The FASEB Journal Metabolism Cytonuclear HALO
Ki67 reproducibility using digital image analysis: an inter-platform and inter-operator study Acs B, Pelekanou V, Bai Y, Martinez-Morilla S, Toki M, Leung SCY, Nielsen TO, Rimm DL 2017 Laboratory Invesigations Oncology Classifier, Cytonuclear HALO
Efficacy of injectable praziquantel for elimination of trematode metacercariae in bluegills (Lepomis macrochirus) and quantification of parasite death by propidium iodide staining Bader C, Chelladurai JJ, Starling DE, Jones DE, Brewer MT 2017 Parasitology Research Infectious Disease Area Quantification HALO
Both brown adipose tissue and skeletal muscle thermogenesis processes are activated during mild to severe cold adaptation in mice Bal NC, Singh S, Reis FCG, Maurya SK, Pani S, Rowland LA, Periasamy M 2017 Journal of Biological Chemistry Myology Area Quantification HALO
Sex- and Dose-Specific Effects of Maternal Bisphenol A Exposure on Pancreatic Islets of First- and Second-Generation Adult Mice Offspring Bansal A, Rashid C, Xin F, Li C, Polyak E, Duemler A, van der Meer T, Stefaniak M, Wajid S, Doliba N, Bartolomei MS, Simmons RA 2017 Environmental Health Perspectives Metabolism Area Quantification HALO
The R-enantiomer of ketorolac delays mammary tumor development in mouse mammary tumor virus-polyoma middle T antigen (MMTV-PyMT) mice AS Peretti, D Dominguez, MM Grimes, HJ Hathaway, ER Prossnitz, MR Rivera, A Wandinger-Ness, D Kusewitt, LG Hudson 2017 The American Journal of Pathology Oncology Classifier, Area Quantification, Cytonuclear HALO
The clinical impact of tumour-infiltrating lymphocytes in colorectal cancer differs by anatomical subsite: A cohort study Berntsson J, Svensson MC, Leandersson K, Nodin B, Micke P, Larsson AH, Eberhard J, Jirstrom K 2017 International Journal of Cancer Oncology, Immuno-oncology Cytonuclear HALO
Acetate Recapturing by Nuclear Acetyl-CoA Synthetase 2 Prevents Loss of Histone Acetylation during Oxygen and Serum Limitation Bulusu V, Tumanov S, Michalopoulou E, van den Broek NJ, MacKay G, Nixon C, Dhayade S, Schug ZT, Voorde JV, Blyth K, Gottlieb E, Vazquez A, Kamphorst JJ 2017 Cell Reports Oncology, Metabolism Cytonuclear HALO
Loss of the imprinted, non-coding Snord116 gene cluster in the interval deleted in the Prader Willi syndrome results in murine neuronal and endocrine pancreatic developmental phenotypes Burnett LC, Hubner G, LeDuc C, Morabito MV, Carli JFM, Leibel RL 2017 Human Moledular Genetics Metabolism Cytonuclear HALO
Identification of the SUMO E3 ligase PIAS1 as a potential survival biomarker in breast cancer Chanda A, Chan A, Deng L, Kornaga EN, Enwere EK, Morris DG, Bonni S 2017 PLOS One Oncology Classifier, Cytonuclear HALO
Spatial distribution of†EGFR†and†KRAS†mutation frequencies correlates with histological growth patterns of lung adenocarcinomas Dietz S, Harms A, Endris V, Eichhorn, Kriegsmann M, LonguespÈe R, Stenzinger A, S¸ltmann H, Warth A, and Kazdal D 2017 International Journal of Cancer Oncology Cytonuclear HALO
Aging African green monkeys manifest transcriptional, pathological, and cognitive hallmarks of human Alzheimer's disease Cramer PE, Gentzel RC, Tanis KQ, Vardigan J, Wang Y, Connolly B, Manfre P, Lodge K, Renger JJ, Zerbinatti C, Uslaner JM 2017 Neurobiology of Aging Neuroscience Object Colocalization HALO
Retinoic-acid-orphan-receptor-C inhibition suppresses Th17 cells and induces thymic aberrations Guntermann C, Piaia A, Hamel M-L, Theil D, Rubic-Schneider T, del Rio-Espinola A, Dong L, Billich A, Kaupmann K, Dawson J, Hoegenauer K, Orain D, Hintermann S, Stringer R, Pate DD, Doelemeyer A, Deurinck M, and Sch¸mann J 2017 JCI Insight Oncology, Immuno-oncology Area Quantification, Cytonuclear HALO
Digital image analysis agrees with visual estimates of bone marrow trephine biopsy cellularity Hagiya AS, Etman A, Siddiqi IN, Cen S, Matcuk Jr GR, Brynes RK, Salama ME 2017 International Journal of Laboratory Hematology Oncology Cytonuclear HALO
Selective imaging of internalized proteopathic ?-synuclein seeds in primary neurons reveals mechanistic insight into transmission of synucleinopathies Karpowicz RJ, Haney CM, Mihaila TS, Sandler RM, Petersson EJ, and Lee VM-Y 2017 Journal of Biological Chemistry Neuroscience Area Quantification, Cytonuclear HALO
Prevalence of somatic mitochondrial mutations and spatial distribution of mitochondria in non-small cell lung cancer Kazdal D,†Harms A,†Endris V,†Penzel R,†Oliveira C, Kriegsmann M,†Longuespee R, Winter H, Schneider MA,†Muley T, Pfarr N,†Weichert W,†Stenzinger A,Warth A 2017 British Journal of Cancer Oncology Cytonuclear HALO
Amino Acid Transporter Slc38a5 Controls Glucagon Receptor Inhibition-Induced Pancreatic ? Cell Hyperplasia in Mice Kim J, Okamoto H, Huang ZJ, Anguiano G, Chen S, Liu Q, Cavino K, Xin Y, Na E, Hamid R, Lee J, Zambrowicz B, Unger R, Murphy AJ, Xu Y, Yancopoulos GD, Li W, Gromada J 2017 Cell Metabolism Metabolism Cytonuclear HALO
APNG as a prognostic marker in patients with glioblastoma Fosmark S, Hellwege S, Dahlrot RH, Jensen KL, Derand H, Lohse J, S¯rensen MD, Hansen S, Kristensen BW 2017 PLOS One Oncology ISH/FISH HALO
TGF?†pathway limits dedifferentiation following WNT and MAPK pathway activation to suppress intestinal tumourigenesis Cammareri P, Vincent DF, Hodder MC, Ridgway RA, Murgia C, Nobis M, Campbell AD, Varga J, Huels DJ, Subramani C, Prescott KLH, Nixon C, Hedley A, Barry ST, Greten FR, Inman GJ, and Sansom OJ 2017 Cell Death and Differentiation Oncology Layer Thickness HALO
Digital analysis and epigenetic regulation of the signature of rejection in colorectal cancer Koelzer VH, Sokol L, Zahnd S, Christe L, Dawson H, Berger MD, Inderbitzin D, Zlobec I, Lugli A 2017 OncoImmunology Oncology Cytonuclear HALO
Asymmetry of post-mortem neuropathology in behavioural-variant frontotemporal dementia DJ Irwin, CT McMillan, SX Xie, K Rascovsky, VM Van Deerlin, HB Coslett, R Hamilton, G Aguirre, EB Lee, VMY Lee, JQ Trojanowski, M Grossman 2017 Brain Neuroscience Area Quantification, Partitions (tiles, margins) HALO
Co-clinical Analysis of a Genetically Engineered Mouse Model and Human Prostate Cancer Reveals Significance of†NKX3.1†Expression for Response to 5?-reductase Inhibition Dutta A, Panja S, Virk RK, Kim JY, Zott R, Cremers S, Golombos DM, Liu D, Mosquera JM, Mostaghel EA, Barbieri CE, Mitrofanova A, Abate-Shen C 2017 European Urology Oncology Area Quantification HALO
Amyloid-? plaques enhance Alzheimer's brain tau-seeded pathologies by facilitating neuritic plaque tau aggregation He Z, Guo JL, McBride JD, Narasimhan S, Kim H, Changolkar L, Zhang B, Gathagan RJ, Yue C, Dengler C, Stieber A, Nitla M, Coulter DA, Abel T, Brunden KR, Trojanowski JQ, Lee V M-Y 2017 Nature Medicine Neuroscience Area Quantification HALO
An ancestral retroviral protein identified as a therapeutic target in type-1 diabetes Levet S, Medina J, Joanou J, Demolder A, Queruel N, RÈant K, Normand M, Seffals M, Dimier J, Germi R, Piofczyk T, Portoukalian J, Touraine J-L, Perron H 2017 JCI Insight Immunology, Metabolism Classifier, Cytonuclear HALO
Receptor tyrosine kinase expression and phosphorylation in canine nasal carcinoma Hocker SA, Higginbotham ML, Schermerhorn T, Henningson J 2017 Research in Veterinary Science Oncology Area Quantification, Multiplex IHC HALO
Differential roles of RET isoforms in medullary and papillary thyroid carcinomas Lian EY, Maritan SM, Cockburn JG, Kasaian K, Crupi MJF, Hurlbut D, Jones SJM, Wiseman SM, Mulligan LM 2017 Endocrine-Related Cancer Oncology Cytonuclear HALO
Ante mortem CSF tau levels correlate with post mortem tau pathology in FTLD Irwin DJ, Lle√õ A, Xie SX, McMillan CT, Wolk D, Lee EB, Van Deerlin VM, Shaw LM, Trojanowski JQ, Grossman M 2017 Annals of Neurology Neuroscience Area Quantification HALO
Neutorphils dominate the immune cell composition in non-small cell lung cancer Kargl J, Busch SE, Yang GHY, Kim K-H, Hanke ML, Metz HE, Hubbard JJ, Lee SM, Madtes DK, McIntosh MW, Houghton AM 2017 Nature Communications Oncology Area Quantification HALO
DPP9 enzyme activity controls survival of mouse migratory tongue muscle progenitors and its absence leads to neonatal lethality due to suckling defect Kim M, Minoux M, Piaia A, Kueng B, Gapp B, Weber D, Haller C, Barbieri S, Namoto K, Lorenz T, Wirsching J, Bassilana F, Dietrich W, Rijli FM, Ksiazek I 2017 Developmental Biology Myology Classifier, Area Quantification HALO
Connexin-43 and aquaporin-4 are markers of ageing-related tau astrogliopathy (ARTAG)-related astroglial response Kovacs GG, Yousef A, Kaindl S, Lee VM, Trojanowski JQ 2017 Neuropathology and Applied Neurobiology Neuroscience Area Quantification HALO
Angptl4 does not control hyperglucagonemia or ?-cell hyperplasia following glucagon receptor inhibition Okamoto H, Cavino K, Na E, Krumm E, Kim SY, Stevis PE, Harp J, Murphy AJ, Yancopoulos GD, Gromada J 2017 Proceedings of the National Academy of Sciences Metabolism Area Quantification HALO
Glucagon receptor inhibition normalizes blood glucose in severe insulin-resistant mice Okamoto H, Kim J, Aglione JP, Lee J, Cavino K, Na E, Rafique A, Kim JH, Harp J, Valenzuela DM, Yancopoulos GD, Murphy AJ, Gromada J 2017 Proceedings of the National Academy of Sciences Metabolism Area Quantification HALO
Cysteinyl leukotriene receptor 1 facilitates tumorigenesis in a mouse model of colitis-associated colon cancer Osman J, Savari S, Chandrashekar NK, Bellamkonda K, Souglas D, Sjolander A 2017 Oncotarget Oncology, Immunology Classifier, Area Quantification HALO
Plant-based vaccines for oral delivery of type 1 diabetes-related autoantigens: Evaluating oral tolerance mechanisms and disease prevention in NOD mice Posgai AL, Wasserfall CH, Kwon K-C, Daniell H, Schatz DA, Atkinson MA 2017 Scientific Reports Metabolism Area Quantification HALO
cFOS-SOX9 Axis Reprograms Bone Marrow-Derived Mesenchymal Stem Cells into Chondroblastic Osteosarcoma He Y, Zhu W, Shin MH, Gary J, Liu C, Dubois W, Hoover SB, Jiang S, Marrogi E, Mock B, Simpson RM, and Huang J 2017 Stem Cell Reports Oncology Classifier HALO
Modulating the therapeutic response of tumours to dietary serine and glycine starvation Maddocks ODK, Athineos D, Cheung EC, Lee P, Zhang T, van den Broek NJF, Mackay GM, Labuschagne CF, Gay D, Kruiswijk F, Blagih J, Vincent DF, Campbell KJ, Ceteci F, Sansom OJ, Blyth K, Vousden KH 2017 Nature Oncology Cytonuclear HALO
Expression of protein disulfide isomerase family members correlates with tumor progression and patient survival in ovarian cancer Samanta S, Tamura S, Dubeau L, Mhawech-Fauceglia P, Miyagi Y, Kato H, Lieberman R, Buckanovich RJ, Lin YG, Neamati N 2017 Oncotarget Oncology Area Quantification HALO
Targeting autophagy inhibits melanoma growth by enhancing NK cells infiltration in a CCL5-dependent manner Mgrditchiana T, Arakeliana T, Paggettia J, Nomana MZ, Virya E, Moussaya E, Van Moera K, Kreisb S, Guerinc C, Buartd S, Roberte C, Borgf C, Vielhg P, Chouaibd S, Berchema G, Janji B 2017 Proceedings of the National Academy of Sciences Oncology, Immuno-oncology Cytonuclear HALO
Weight Pertubation Alters Leptin Signal Transduction in a Region-Specific Manner throughout the Brain Morabito MV, Ravussin Y, Mueller BR, Skowronski AA, Watanabe K, Foo KS, Lee SX, Lehmann A, Hjorth S, ZeltserLM, LeDuc CA, Leibel RL 2017 PLOS One Metabolism Cytonuclear HALO
A single dose of peripherally infused EGFRvIII-directed CAR T cells mediates antigen loss and induces adaptive resistance in patients with recurrent glioblastoma OíRourke DM, Nasrallah MP, Desai A, Melenhorst JJ, Mansfield K, MorrissetteJJD, Martinez-Lage M, Brem S, Maloney E, Shen A, Isaacs R, Mohan S, Plesa G, Lacey SF, Navenot J-M, Zheng Z, Levine BL, Okada H, June CH, Brogdon JL, Maus MV 2017 Science Translational Medicine Oncology, Immuno-oncology Cytonuclear, Multiplex IHC HALO
The action of ?-hydroxybutyrate on the growth, metabolism and global histone H3 acetylation of spontaneous mouse mammary tumours: evidence of a ?-hydroxybutyrate paradox Rodrigues LM, Uribe-Lewis S, Madhu B, Honess DJ, Stubbs M, Griffiths JR 2017 Cancer & Metabolism Oncology, Metabolism Area Quantification, Cytonuclear HALO
High levels of tumor-associated neutrophils are associated with improved overall survival in patients with stage II colorectal cancer RS Berry, M-J Xiong, A Greenbaum, P Mortaji, RA Nofchissey, F Schultz, C Martinez, L Luo, KT Morris, JA Hanson 2017 PLOS One Oncology, Immuno-oncology Cytonuclear HALO
Pathological tau strains from human brains recapitulate the diversity of tauopathies in non-transgenic mouse brain S Narasimhan, JL Guo, L Changolkar, A Stieber, JD McBride, LV Silva, Z He, B Zhang, RJ Gathagan, JQ Trojanowski, VMY Lee 2017 Journal of Neuroscience Neuroscience Cytonuclear HALO
T-cell Localization, Activation, and Clonal Expansion in Human Pancreatic Ductal Adenocarcinoma Stromnes IM, Hulbert A, Pierce RH, Greenberg PD, Hingorani SR 2017 Cancer Immunology Research Oncology, Immuno-oncology Highplex FL HALO
Transcriptional mechanisms of resistance to anti-PD-1 therapy Ascierto ML, Makohon-Moore A, Lipson EJ, Taube JM, McMiller TL, Berger AE, Fan J, Kaunitz GJ, Cottrell TR, Kohutek ZA, Favorov A, Makarov V, Riaz N, Chan TA, Cope L, Hruban RH, Pardoll DM, Taylor BS, Solit DB, Iacobuzio-Donahue CA, Topalian SL 2017 Clinical Cancer Research Oncology, Immuno-oncology Immune HALO
Comparison of branch and distally focused main renal artery denervation using two different radio-frequency systems in a porcine model Mahfoud F, Pipenhagen CA, Moon LB, Ewen S, Kulenthiran S, Fish JM, Jensen JA, Virmani R, Joner M, Yahagi K, Tsioufis C, BÀÜhm M 2017 International Journal of Cardiology Myology Layer Thickness HALO
Treatment with the WNT5A-mimicking peptide Foxy-5 effictively reduces the metastatic spread of WNT5A-low prostate cancer cells in an orthotopic mouse model Canesin G, Evans-Axelsson S, Hellsten R, Krzyzanowska A, Prasad CP, Bjartell A, Andersson T 2017 PLOS One Oncology Membrane HALO
Expression of PD-L1 and presence of CD8-positive T cells in pre-treatment specimens of locally advanced cervical cancer Enwere EK, Kornaga EN, Dean M, Koulis TA, Phan T, Kalantarian M, KÀÜbel M, Ghatage P, Magliocco AM, Lees-Miller DP, Doll CM 2017 Modern Pathology Oncology, Immuno-oncology Membrane HALO
Association of HIV Status With Local Immune Response to Anal Squamous Cell Carcinoma: Implications for Immunotherapy Yanik EL, Kaunitz GJ, Cottrell TR, Succaria F, McMiller TL, Ascierto ML, Esandrio J, Xu H, Ogurtsova A, Cornish T, Lipson EJ, Topalian SL, Engels EA, Taube JM 2017 JAMA Oncology Oncology, Immuno-oncology Cytonuclear HALO
Chronic Verubecestat Treatment Suppresses Amyloid Accumulation in Advanced Aged Tg2576-A?PPswe Mice Without Inducing Microhemorrhage Villarreal S, Zhao F, Hyde LA, Holder D, Forest T, Sondey M, Chen X, Sur C, Parker EM, Kennedy ME 2017 Journal of Alzheime's Disease Neuroscience Object Colocalization HALO
In vivo characterization of a new type of biodegradable starch microsphere for transarterial embolization Sommer CM, Do TD, Schlett CL, Flechsig P, Gockner TL, Kuthning A, Vollherbst DF, Pereira PL, Kauczor HU, Macher-GÀÜppinger S 2017 Journal of Biomaterials Applications Oncology Classifier HALO
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Phosphorylation of calcium/calmodulin-stimulated protein kinase II at T286 enhances invasion and migration of human breast cancer cells Chi M, Evans, Gilchrist J, Mayhew J, Hoffman A, Pearsall EA, Jankowski H, Brzozowski JS, Skelding KA 2016 Scientific Reports Oncology Cytonuclear HALO
Evidence of ?-Cell Dedifferentiation in Human Type 2 Diabetes Cinti F, Bouchi R, Kim-Muller JY, Ohmura Y, Sandoval PR, Masini M, Marselli L, Suleiman M, Ratner LE, Marchetti P, Accili D 2016 The Journal of Clinical Endocrinology & Metabolism Metabolism Cytonuclear HALO
Cutaneous wound healing through paradoxical MAPK activation by BRAF inhibitors Escuin-Ordinas H, Li S, Xie MW, Sun L, Hugo W, Huang RR, Jiao J, Meira de-Faria F, Realegeno S, Krystofinski P, Azhdam A, Komenan SMD, Atefi M, Comin-Anduix B, Pellegrini M, Cochran AJ, Modlin RL, HerschmanHR, Lo RS, McBride WH, Segura T, Ribas A 2016 Nature Communications Wound Healing Cytonuclear HALO
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A Depot Medroxyprogesterone Acetate Dose That Modes Human Use and Its Effect on Vaginal SHIV Acquisition Risk Butler K, Ritter JM, Ellis S, Morris MR, Hanson DL, McNicholl JM, Kersh EN 2016 J Acquir Immune Defic Syndr Infectious Disease Layer Thickness HALO
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The Dynamics and Turnover of Tau Aggregates in Cultured Cells: Insights into Therapies for Tauopathies Guo JL, Buist A, Soares A, Callaerts K, Calafate S, Stevenaert F, Daniels JP, Zoll BE, Crowe A, Brunden KR, Moechars D, Lee VMY 2016 The Journal of Biological Chemistry Neuroscience Area Quantification HALO
Unique pathological tau conformers from Alzheimer's brains transmit tau pathology in nontransgenic mice Guo JL, Narasimhan S, Changolkar L, He Z, Stieber Z, Zhang B, Gathagan RJ, Iba M, McBride JD, Trojanowski JQ, Lee VMY 2016 Journal of Experimental Medicine Neuroscience Area Quantification HALO
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Cerebral Protection During MitraClip Implantation: Initial Experience at 2 Centers Frerker C, Schl¸ter M, Sanchez OD, Reith S, Romero ME, Ladich E, Schrˆder J, Schmidt T, Kreidel F, Joner M 2016 JACC: Cardiovascular Interventions Myology Object Colocalization HALO
Upregulation of Glucose-Regulated Protein 78 in Metastatic Cancer Cells Is Necessary for Lung Metastasis Progression Lizardo MM, Morrow JJ, Miller TE, Hong ES, Ren L, Mendoza A, Halsey CH, Scacheri PC, Helman LJ, Khanna C 2016 Neoplasia Oncology Cytonuclear HALO
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Comparison of the methods for measuring the Ki-67 labeling index in adrenocortical carcinoma: manual versus digital image analysis Yamazaki Y, Nakamura Y, Shibahara Y, Konosu-Fukaya S, Sato N, Kubota-Nakayama F, Oki Y, Baba S, Midorikawa S, Morimoto R, Satoh F, Sasano 2016 Human Pathology Oncology Cytonuclear HALO
Variability in Platelet-Derived Growth Factor Receptor Alpha Antibody Specificity May Impact Clinical Utility of Immunohistochemistry Assays Holzer TR, Reising LO, Credille KM, Schade AE, Oakley 2016 Journal of Histochemistry & Cytochemistry Oncology Cytonuclear, ISH/FISH HALO
Differential Cytokine Gene Expression in Granulomas from Lungs and Lymph Nodes of Cattle Experimentally Infected with Aerosolized Mycobacterium bovis Palmer MV, Thacker TC, Waters WR 2016 PLOS One Infectious Disease ISH/FISH HALO
Single-Cell RNAseq Reveals That Pancreatic β-Cells From Very Old Male Mice Have a Young Gene Signature Xin Y, Kim J, Okamoto H, Ni M, Wei Y, Adler C, Murphy AJ, Yancopoulos GD, Lin C, Gromada J 2016 Endocrinology Metabolism Islet HALO
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Solid-state NMR structure of a pathogenic fibril of full-length human [alpha]-synuclein Tuttle MD, Comellas G, Nieuwkoop AJ, Covell DJ, Berthold DA, Kloepper KD, Courtney JM, Kim JK, Barclay AM, Kendall A, Wan W, Stubbs G, Schwieters CD, Lee VMY, George JM, Rienstra CM 2016 Structural & Molecular Biology Neuroscience Area Quantification HALO
RNA Sequencing of Single Human Islet Cells Reveals Type 2 Diabetes Genes Xin Y, Kim J, Okamoto H, Ni M, Wei Y, Adler C, Murphy AJ, Yancopoulos GD, Lin C, Gromada J 2016 Cell Metabolism Metabolism ISH/FISH HALO
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The PDE10A inhibitor MP-10 and haloperidol produce distinct gene expression profiles in the striatum and influence cataleptic behavior in rodents Gentzel RC, Toolan D, Roberts R, Koser AJ, Kandebo M, Hershey J, Renger JJ, Uslaner J, Smith SM 2015 Neuropharmacology Neuroscience Cytonuclear HALO
Phenotyping of tumor-associated macrophages in colorectal cancer: impact on single cell invasion (tumor budding) and clinicopathological outcome Koelzer VH, Canonica K, Dawson H, Sokol L, Karamitopoulou-Diamantis E, Lugli A, Zlobec I 2015 OncoImmunology Oncology, Immuno-oncology, Gastroenterology Cytonuclear HALO
G-protein-independent coupling of MC4R to Kir7. 1 in hypothalamic neurons Ghamari-Langroudi M, Digby GJ, Sebag JA, Millhauser GL, Palomino R, Matthews R, Gillyard T, Panaro BL, Tough IR, Cox HM, Denton JS, Cone RD 2015 Nature Metabolism ISH/FISH HALO
Analysis of putative mucosal SHIV susceptibility factors during repeated DMPA treatments in pigtail macaques Butler K, Ritter J, Ellis S, Henning TR, Montague J, Zaki S, Garber, McNicholl JM, Kersh EN 2015 Journal of medical primatology Infectious Disease Layer Thickness HALO
Semi-Automated Digital Image Analysis of Pick's Disease and TDP-43 Proteinopathy Irwin DJ, Byrne MD, McMillan CT, Cooper F, Arnold SE, Lee EB, Van Deerlin VM, Xie SX, Lee VM, Grossman M, Trojanowski JQ 2015 Journal of Histochemistry & Cytochemistry Neuroscience Object Colocalization, Layer Thickness HALO
Myostatin blockade with a fully human monoclonal antibody induces muscle hypertrophy and reverses muscle atrophy in young and aged mice Latres E, Pangilinan J, Miloscio L, Bauerlein R, Na E, Potocky TB, Huang Y, Eckersdorff M, Rafique A, Mastaitis J, Lin C, Murphy AJ, Yancopoulos GD, Gromada J, Stitt T 2015 Skeletal Muscle Myology Muscle Fiber HALO
Relationship of Estimated SHIV Acquisition Time Points During the Menstrual Cycle and Thinning of Vaginal Epithelial Layers in Pigtail Macaques Kersh EN, Ritter J, Butler K, Ostergaard SD, Hanson D, Ellis S, Zaki S, McNicholl JM 2015 Sexually Transmitted Diseases Infectious Disease Layer Thickness HALO
Glucagon Receptor Blockade With a Human Antibody Normalizes Blood Glucose in Diabetic Mice and Monkeys Okamoto H, Cavino K, Na E, Krumm E, Kim SY, Cheng X, Murphy AJ, Yancopoulos GD, Gromada J 2015 Endocrinology Metabolism Area Quantification HALO
Nerve fibers infiltrate the tumor microenvironment and are associated with nerve growth factor production and lymph node invasion in breast cancer Pundavela J, Roselli S, Faulkner S, Attia J, Scott RJ, Thorne RF, Forbes JF, Bradshaw RA, Walker MM, Jobling P, Hondermarck H 2015 Molecular Oncology Oncology, Neuroscience Area Quantification HALO
Tasquinimod triggers an early change in the polarization of tumor associated macrophages in the tumor microenvironment Olsson A, Nakhle J, Sundstedt A, Plas P, Bauchet AL, Pierron V, Bruetschy L, Deronic A, Tomgren M, Liberg D, Schmidlin F, Leanderson T 2015 Journal for ImmunoTherapy of Cancer Oncology, Immuno-oncology Cytonuclear HALO
Exacerbated experimental colitis in TNFAIP8-deficient mice Sun H, Lou Y, Porturas T, Morrissey S, Luo G, Qi J, Ruan Q, Shi S, Chen YH 2015 The Journal of Immunology Gastroenterology Cytonuclear HALO
Combination therapy reverses hyperglycemia in NOD mice with established type 1 diabetes Xue S, Posgai A, Wasserfall C, Myhr C, Campbell-Thompson M, Mathews CE, Brusko T, Rabinovitch A, Savinov A, Battaglia M, Schatz D, Haller M, Atkinson MA 2015 Diabetes Metabolism Cytonuclear HALO
A combined oral contraceptive affects mucosal SHIV susceptibility factors in a pigtail macaque (Macaca nemestrina) model Ostergaard DS, Butler K, Ritter JM, Johnson R, Sanders J, Powell N, Lathrop G, Zaki SR, McNicholl JM, Kersh EN 2015 Journal of medical primatology Infectious Disease Layer Thickness HALO
Applicability of digital analysis and imaging technology in neuropathology assessment Dunn WD, Gearing M, Park Y, Zhang L, Hanfelt J, Glass JD, Gutman DA 2015 Neuropathology HALO
Islet-1 is essential for pancreatic ?-cell function Ediger BN, Du A, Liu J, Hunter CS, Walp ER, Schug J, Kaestner KH, Stein R, Stoffers DA, May CL 2014 Diabetes Metabolism Cytonuclear HALO
Characterization of the exocrine pancreas in the male Zucker diabetic fatty rat model of type 2 diabetes mellitus following 3 months of treatment with sitagliptin Forest T, Holder D, Smith A, Cunningham C, Yao X, Dey M, Frederick C, Prahalada S 2014 Endocrinology Metabolism Cytonuclear HALO
Peripheral androgen receptor gene suppression rescues disease in mouse models of spinal and bulbar muscular atrophy Lieberman AP, Yu Z, Murray S, Peralta R, Low A, Guo S, Yu XX, Cortes CJ, Bennett CF, Monia BP, La Spada AR, Hung G 2014 Cell Reports Myology Muscle Fiber HALO
ANGPTL8/betatrophin does not control pancreatic beta cell expansion Gusarova V, Alexa CA, Na E, Stevis PE, Xin Y, Bonner-Weir S, Cohen JC, Hobbs HH, Murphy AJ, Yancopoulos GD, Gromada J 2014 Cell Metabolism Area Quantification HALO
PD-1 blockade induces responses by inhibiting adaptive immune resistance Tumeh PC, Harview CL, Yearley JH, Shintaku IP, Taylor EJM, Robert L, Chmielowski B, Spasic M, Henry G, Ciobanu V, West AN, Carmona M, Kivork C, Seja E, Cherry G, Gutierrez A, Grogan TR, Mateus C, Tomasic G, Glaspy JA, Emerson RO, Robins H, Pierce RH, Elas 2014 Nature Oncology, Immuno-oncology Cytonuclear HALO
Marked expansion of exocrine and endocrine pancreas with incretin therapy in humans with increased exocrine pancreas dysplasia and potential for glucagon-producing neuroendocrine tumors Butler AE, Campbell-Thompson M, Gurlo T, Dawson DW, Atkinson M, Butler PC 2013 Diabetes Oncology, Metabolism Cytonuclear HALO
CRISPR-Cas9 gene editing of hepatitis B virusin chronically infected humanized mice Stone D, Long KR, Loprieno MA, De Silva Feelixge HS, Kenkel EJ, Liley, RM, Rapp S, Roychoudhury P, Nguyen T, Stensland L, C√õlon-Thillet R, Klouser LM, Weber ND, Le C, Wagoner J, Goecker EA, Li AZ, Eichholz K, Corey L, Tyrrell DL, Greninger AL, Huang ML, Polyak SJ, Aubert M, Sagartz JE, Jerome KR 2021 Molecular Therapy Methods & Clinical Development Infectious Disease HALO Link
Digital Immunophenotyping Predicts Disease Free and Overall Survival in Early Stage Melanoma Patients De Logu F, Galli F, Nassini R, Ugolini F, Simi S, Cossa M, Miracco C, Gianatti A, De Giorgi V, Rulli E, Cossu A, Massi D, Mandal‡ M 2021 Cells Oncology, Immuno-oncology Multiplex IHC HALO, HALO Link
Monomeric/dimeric forms of Fgf15/FGF19 show differential activity in hepatocyte proliferation and metabolic function Williams CM, Calderon JH, Hock E, Jimenez Y, Barringer K, Carbonaro M, Molina-Portela MP, Thurston G, Li Z, Daly C 2021 The FASEB Journal Metabolism Cytonuclear HALO, HALO Link
CD38 in Advanced Prostate Cancers Guo C, Crespo M, Gurel B, Dolling D, Rekowski J, Sharp A, Petremolo A, Sumanasuriya S, Rodrigues DN, Ferreira A, Pereira R, Figueiredo I, Mehra N, Lambros MBK, Neeb A, Gil V, Seed G, Terstappen L, Alimonti A, Drake CG, Yuan W, de Bono JS 2021 European Urology Oncology Classifier, Highplex FL HALO
Exploring transcriptional regulators Ref-1 and STAT3 as therapeutic targets in malignant peripheral nerve sheath tumours Gampala S, Shah F, Zhang C, Rhodes SD, Babb O, Grimard M, Wireman RS, Rad E, Calver B, Bai R-Y, Staedtke V, Hulsey EL, Saadatzadeh MR, Pollok KE, Tong Y, Smith AE, Clapp DW, Tee AR, Kelley MR, Fishel ML 2021 British Journal of Cancer Oncology Area Quantification, Cytonuclear HALO
First in class dual MDM2/MDMX inhibitor ALRN-6924 enhances antitumor efficacy of chemotherapy in TP53 wild-type hormone receptor-positive breast cancer models Pairawan S, Zhao M, Yuca E, Annis A, Evans K, Sutton D, Carvajal L, Ren J-G, Santiago S, Guerlavais, Akcakanat A, Tapia C, Yang F, Bose PSC, Zheng X, Dumbrava EI, Aivado M, Meric-Bernstam F 2021 Breast Cancer Research Oncology Cytonuclear HALO
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Phenotypic characterization of Adig null mice suggests roles for adipogenin in the regulation of fat mass accrual and leptin secretion Alvarez-Guaita A, Patel S, Lim K, Haider A, Dong L, Conway OJ, Ma MKL, Chiarugi D, Saudek V, O'Rahilly S, Savage DB 2021 Cell Reports Metabolism Vacuole HALO
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An extended release GLP-1 analogue increases ?-synuclein accumulation in a mouse model of prodromal Parkinson's disease Bergkvist L, Johnson ME, Mercado G, Steiner JA, Meyerdick L, Schulz E, Madaj Z, Ma J, Becker K, Li Y, Brudin P 2021 Experimental Neurology Neuroscience Area Quantification HALO
Activation of the renal GLP?1R leads to expression of Ren1 in the renal vascular tree Bj¯rnholm KD, Ougaard ME, Skovsted GF, Knudsen LB, Pyke C 2021 Endocrinology, Diabetes, & Metabolism Metabolism ISH/FISH HALO
A Method to Pre-Screen Rat Mammary Gland Whole-Mounts Prior To RNAscope Duderstadt EL, Sanders MA, Samuelson DJ 2021 Journal of Mammary Gland Biology and Neoplasia ISH/FISH HALO
Activated Regulatory T-Cells, Dysfunctional and SenescentT-Cells Hinder the Immunity in Pancreatic Cancer Sivakumar S, Abu-Shah E, Ahern DJ, Arbe-Barnes EH, Jainarayanan AK, Mangal N, Reddy S, Rendek A, Easton A, Kurz E, Silva M, Soonawalla Z, Heij LR, Bashford-Rogers R, Middleton MR, DUstin ML 2021 cancers Classifier, Multiplex IHC, Spatial Analysis, Highplex FL HALO
Age-associated expression of p21and p53 during human wound healing Chia CW, Sherman-Baust CA, Larson SA, Pandey R, Withers R, Karikkineth AC, Zukley LM, Campisi J, Egan JM, Sen R, Ferrucci L 2021 Aging Cell Dermatology Area Quantification, ISH/FISH, Multiplex IHC HALO
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COM902, a novel therapeutic antibody targeting TIGIT augments anti-tumor T cell function in combination with PVRIG or PD-1 pathway blockade Kyle Hansen K, Sandeep Kumar, Kathryn Logronio, Sarah Whelan, Samir Qurashi, Hsin-Yuan Cheng, Andrew Drake, Margaret Tang, Patrick Wall, David Bernados, Ling Leung, Eran Ophir, Zoya Alteber Z, Gady Cojocaru G, Moran Galperin M, Masha Frenkel M, Mark White M, John Hunter J, Spencer C. Liang & Maya F. Kotturi 2021 Cancer Immunology, Immunotherapy Immuno-oncology HALO
Conventional and semi-automatic histopathological analysis of tumor cell content for multigene sequencing of lung adenocarcinoma Kazdal D, Rempel E, Oliveira C, Allg‰uer M, Harms A, Singer K, Kohlwes E, Ormanns S, Fink L, Kriegsmann J, Leichsenring M, Kriegsmann K, Stˆgbauer F, Tavernar L, Leichsenring J, Volckmar A-L, LonguespÈe R, Winter H, Eichhorn M, Heuflel CP, Herth F, Christopoulos P, Reck M, Muley T, Weichert W, Budczies J, Thomas M, Peters S, Warth A, Schirmacher P, Stenzinger A, Kriegsmann M 2021 Translational Lung Cancer Research Oncology Classifier, Cytonuclear HALO
Crotonaldehyde exposure induces liver dysfunction and mitochondrial energy metabolism disorder in rats Zhang S, Zhang B, Zhang Q, Zhang Z 2021 Toxicology Mechanisms and Methods Metabolism HALO
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Immune-regulated IDO1-dependent tryptophan metabolism is source of one-carbon units for pancreatic cancer and stellate cells Newman AC, Falcone M, Uribe AH, Zhang T, Athineos D, Pietzke M, Vazquez A, Blyth K, Maddocks ODK 2021 Molecular Cell Immuno-oncology Classifier, ISH/FISH HALO
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Tracing Lung Cancer Risk Factors Through Mutational Signatures in Never-Smokers Landi MT, Synnott NC, Rosenbaum J, Zhang T, Zhu B, Shi J, Zhao W, Kebede M, Sang J, Choi J, Mendoza L, Pacheco M, Hicks B, Caporaso NE, Abubakar M, Gordenin DA, Wedge, Alexandrov LB, Rothman N, Lan Q, Garcia-Closas M, Chanock SJ 2021 American Journal of Epidemiology Oncology HALO
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VGLUT2 is a determinant of dopamine neuron resilience in a rotenone model of dopamine neurodegeneration Buck SA, De Miranda BR, Logan RW, Fish KN, Greenamyre JT, Freyberg Z 2021 The Journal of Neuroscience Neuroscience ISH/FISH HALO
Ki-67 Proliferation Index Assessment in Gastroenteropancreatic Neuroendocrine Tumors by Digital Image Analysis With Stringent Case and Hotspot Level Concordance Requirements Boukhar SA, Gosse MD, Bellizzi AM, Rajan A 2021 American Journal of Clinical Pathology Oncology HALO
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Mastocytosis-derived extracellular vesicles deliver miR-23a and miR-30a into pre-osteoblasts and prevent osteoblastogenesis and bone formation Kim D-K, Bandara G, Cho Y-E, Komarow HD, Donahue DR, Karim B, Baek M-C, Kim HM, Metcalfe DD, Olivera A 2021 Nature Communications Classifier HALO
Mitigation of endemic GI-tract pathogen-mediated inflammation through development of multimodal treatment regimen and its impact on SIV acquisition in rhesus macaques Bochart RM, Busman-Sahay K, Bondoc S, Morrow DW, Ortiz AM, Fennessey CM, Fischer MB, Shiel O, Swanson T, Shriver-Munsch CM, Crang HB, Armantrout KM, Barber-Axthelm AM, Langner C, Moats CR, Labriola CS, MacAllister R, Axthelm MK, Brenchley JM, Keele BF, Estes JD, Hansen SG, Smedley JV 2021 PLOS Pathogens Infectious Disease ISH/FISH, Multiplex IHC HALO
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Analysis of genomic and non-genomic signaling of estrogen receptor in PDX models of breast cancer treated with a combination of the PI3K inhibitor alpelisib (BYL719) and fulvestrant Jacquemetton J, Kassem L, Poulard C, Dahmani A, De Plater L, Montaudon E, Sourd L, Morisset L, El Botty R, Chateau-Joubert S, Vacher S, BiËche I, Treilleux I, TrÈdan O, Marangoni E, Le Romancer M 2021 Breast Cancer Research Oncology Multiplex IHC HALO
AP-3-dependent targeting of flippase ATP8A1 to lamellar bodies suppresses activation of YAP in alveolar epithelial type 2 cells Kook S, Wang P, Meng S, Jetter CS, Sucre JMS, Benjamin JT, Gokey JJ, Hanby HA, Jaume A, Goetzl L, Marks MS, Guttentag SH 2021 Proceedings of the National Academy of Sciences Fibrosis HALO
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Pancreatic ?†cellñselective zinc transporter 8 insufficiency accelerates diabetes associated with islet amyloidosis Xu J, Wijesekara N, Regeenes R, Al Rijjal D, Piro AL, Song Y, Anne Wu A, Bhattacharjee A, Liu Y, Marzban L, Rocheleau JV, Fraser PE, Dai FF, Hu C, Wheeler MB 2021 JCI Insight Metabolism HALO
Human Type II Taste Cells Express ACE2 and are Infected by SARS-CoV-2 Doyle M, Ashley Appleton A, Q Liu, Yao Q, Mazucanti C, Egan J 2021 American Journal of Pathology Cytonuclear HALO
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Attenuating CD3 affinity in a PSMAxCD3 bispecific antibody enables killing of prostate tumor cells with reduced cytokine release Dang K, Castello G, Clarke S, et al. 2021 Journal for Immunotherapy of Cancer Immuno-oncology Multiplex IHC HALO
Heterogeneity in tertiary lymphoid structure B-cells correlates with patient survival in metastatic melanom Lynch K, Young S, Menaveau M, et al. 2021 Journal for Immunotherapy of Cancer Immuno-oncology Highplex FL HALO
mRNA translation is a therapeutic vulnerability necessary for bladder epithelial transformation Jana S, Deo R, Hough R, et al. 2021 JCI Insight Oncology Multiplex IHC, Highplex FL HALO
Approaches for Handling Immunopathological and Clinical Data Using Deep Learning Methodology: Multiplex IHC/IF Data as a Paradigm Goh S, Chua Y, Lee J, Yeong J, Cai Y 2021 Histopathology and Liquid Biopsy Review HALO
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Quantification of Human Epidermal Growth Factor Receptor 2 by Immunopeptide Enrichment and Targeted Mass Spectrometry in Formalin-Fixed Paraffin-Embedded and Frozen Breast Cancer Tissues Kennedy J, Whiteaker J, Kennedy L, Bosch D, Lerch M, Schoenherr R, Zhao L, Lin C, Chowdhury S, Kilgore M, Allison K, Wang P, Hoofnagle A, Baird G, Paulovich A 2021 Clinical Chemistry Oncology Classifier HALO
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Lawsonia intracellularis infected enterocytes lack sucrase-isomaltase which contributes to†reduced pig digestive capacity Helm E, Burrough E, Leite, F, Gabler, N 2021 Veterinary Research Other ISH/FISH HALO
Mechanism of Nucleic Acid Sensing in Retinal Pigment Epithelium (RPE): RIG-I Mediates Type I Interferon Response in Human RPE Schustak J, Twarog M, Wu X, Huang Q, Bao Y 2021 Journal of Immunology Research Area Quantification, ISH/FISH HALO
Rejection of benign melanocytic nevi by nevus-resident CD4+†T cells Schiferle E, Cheon S, Ham S, Son H, Messerschmidt J, Lawrence D, Cohen J, Flaherty K, Moon J, Lian C, Sullivan R, Demehri S 2021 Science Advances Oncology Multiplex IHC HALO
Wound healing with topical BRAF inhibitor therapy in a diabetic model suggests tissue regenerative effects Escuin-Ordinas H, Liu Y, Hufo W, Dimatteo R, Huang R, Krystofinski P, Azhdam A, Lee J, Comin-Anduix B, Cochran A, Lo R, Segura T, Scumpia P, Ribas A 2021 PLOS ONE Dermatology Object Colocalization, Multiplex IHC HALO
The Goto Kakizaki rat: Impact of age upon changes in cardiac and renal structure, function Meagher P, Civitarese R, Lee X, Gordon M, Bugyei-Twum A, Desjardins J, Kabir G, Zhang Y, Kosanam H, Visram A, Leong-Poi H, Advani A, Connelly K 2022 PLOS ONE Myology Muscle Fiber HALO
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Dissecting spatial heterogeneity and the immuneevasion mechanism of CTCs by single-cell RNA-seq in hepatocellular carcinoma Sun Y, Wu L, Liu S, Jiang M, Hu B, Zhou K, Guo W, Xu Y, Zhong Y, Zhou X, Zhang Z, Liu G, Liu S, Shi Y, Ji Y, Du M, Li N, Li G, Zhao Z, Huang X, Xu L, Yu Q, Peng D, Qiu S, Sun H, Dean M, Wang X, Chung W, Dennison A, Zhou J, Hou Y, Fan J, Yang X 2021 Nature Communications Oncology, Immuno-oncology Highplex FL HALO
TMEM229A suppresses non?small cell lung cancer progression via inactivating the ERK pathway Zhang X, He Y, Jiang Y, Bao Y, Chen Q, Xie D, Yu H, Wang X 2021 Oncology Reports Multiplex IHC HALO
Glucocorticoid receptor antagonism promotes apoptosis in solid tumor cells Greenstein A, Hunt H 2021 Oncotarget Multiplex IHC HALO
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White adipose tissue autophagy and adipose-liver crosstalk exacerbate nonalcoholic fatty liver disease in mice Sakane S, Hikita H, Shirai K, Myojin Y, Sasaki Y, Kudo S, Fukumoto K, Mizutani N, Tahata Y, Makino Y, Yamada R, Kodama T, Sakamori R, Tatsumi T, Takehara T 2021 Cellular and Molecular Gasteroenterology and Hepatology Metabolism HALO
Neoadjuvant cabozantinib and nivolumab convert locally advanced hepatocellular carcinoma into resectable disease with enhanced antitumor immunity Ho W, Zhu Q, Durham J, Popovic A, Xavier S, Leatherman J, Mohan A, Mo G, Zhang S, Gross N, Charmsaz S, Lin D, Quong D, Wilt B, Kamel I, Weiss M, Philosophe B, Burkhart R, Burns W, Schubert C, Ejaz A, He J, Deshpande A, Danilova L, Stein-O'Brien G, Sugar E, Laheru D, Anders R, Fertig E, Jaffee, E, Yarchoan M 2021 Nature Cancer Oncology HALO
SMAD4 represses FOSL1 expression and pancreatic cancer metastatic colonization Dai C, Rennhack J, Arnoff T, Thaker M, Younger S, Doench J, Huang A, Yang A, Aguirre A, Wang B, Mun E, O'Connel J, Huang Y, Labella K, Talamas J, Li J, Ilic N, Hwang J, Hong A, Giacomelli A, Gjoerup O, Root D, Hahn W 2021 Cell Reports Oncology Area Quantification HALO
A single-dose mRNA vaccine provides a long-term protection for hACE2 transgenic mice from SARS CoV-2 Huang Q, Ji K, Tian S, Wang F, Huang B, Tong Z, Tan S, Hao J, Wang Q, Tan W, Gao G, Yan J 2021 Nature Communications Infectious Disease Multiplex IHC HALO
Endothelial cell infection and dysfunction, immune activation in severe COVID-19 Qin Z, Liu F, Blair R, Wang C, Yang H, Mudd J, Currey J, Iwanaga N, He J, Mi R, Han K, Midkiff C, Alam M, Aktas B, Heide R, Veazey R, Piedimonte G, Maness N, Erg¸n S, Mauvais-Jarvis F, Rappaport J, Kolls J, Qin X 2021 Theranostics Immunology, Infectious Disease Multiplex IHC, Spatial Analysis HALO
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Repeated porphyrin lipoprotein-based photodynamic therapy controls distant disease in mouse mesothelioma via the abscopal effect Lou J, Aragaki M, Bernards N, Kinoshita T, Mo J Motooka Y, Ishiwata T, Gregor A, Chee T, Chen Z, Chen J, Kaga K, Wakasa S, Zheng G, Yasufuku K 2021 Nanophotonics Oncology Cytonuclear HALO
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A preclinical trial and molecularly-annotated patient cohort identify predictive biomarkers in homologous recombination deficient pancreatic cancer Wang Y, Park J, Pacis A, Denroche R, Jang G, Zhang A, Cuggia A, Domecq C, Monlong J, Raitses-Gurevich M, Grant R, Borgida A, Holter S, Stossel C, Bu S, Masoomian M, Lungu I, Bartlett J, Wilson J, Gao Z, Riazalhosseini Y, Asselah J, Bouganim N, Cabrera T, Boucher L, Valenti D, Biagi J, Greenwood C, Polak P, Foulkes W, Golan T, O'Kane G, Fischer S, Knox J, Gallinger S, Zogopoulos G 2020 Clinical Cancer Research Oncology Classifier, Cytonuclear, Multiplex IHC HALO
Epigenetic modifications precede molecular alterations and drive human hepatocarcinogenesis Czauderna C, Poplawski A, O'Roourke C, Castven D, PÈrez-Aguilar B, Becker D, Heilmann-Heimbach S, Odenthal M, Amer W, Schmiel M, Drebber U, Binder H, Ridder D, Schindeldecker M, Straub B, Galle P, Andersen J, Thorgeirsson S, Park Y, Marquardt J 2021 JCI Insight Oncology Cytonuclear, TMA HALO
Allostatic hypermetabolic response in PGC1?/? heterozygote mouse despite mitochondrial defects Rodriguez-Cuenca S, Lelliot C, Campbell M, Peddinti G, Martinuez-UÒa M, Ingvorsen C, Dias A, Relat J, Mora S, Hyˆtyl‰inen T, Zorzano A, Oreöi? M, Bjursell M, Bohlooly-Y M, LindÈn D, Vidal-Puid A 2021 The FASEB Journal Metabolism Vacuole HALO
Distinct immune signatures in peripheral blood predict chemosensitivity in intrahepatic cholangiocarcinoma patients Wu T, Yang Y, Zheng B, Shi X, Li W, Ma W, Wang S, Li Z, Zhu Y, Wu J, Wang K, Zhao Y, Wu R, Sui C, Shen S, Wu X, Chen L, Yuan Z, Wang H 2021 Engineering Oncology, Immunology Highplex FL HALO
Constrictive and Hypertrophic Strictures in Ileal Crohnís Disease Liu Q, Zhang X, Ko H, Stocker D, Ellman J, Chen J, Hao Y, Bhardwaj S, Liang Y, Cho J, Colombel J, Taouli B, Harpaz N 2021 Clinical Gastroenterology and Hepatology Gastroenterology HALO
The amino acid transporter SLC7A5 is required for efficient growth of KRAS-mutant colorectal cancer Najumudeen AK, Ceteci F, Fey SK, Hamm G, Steven RT, Hall H, Nikula CJ, Dexter A, Murta T, Race AM, Sumpton D, Vlahov N, Gay DM, Knight JRP, Jackstadt R, Leach JDG, Ridgway RA, Johnson ER, Nixon C, Hedley A, Gilroy K, Clark W, Malla SB, Dunne PD, Rodriguez-Blanco G, Critchlow SE, Mrowinska A, Malviya G, Solovyev D, Brown G, Lewis DY, Mackay GM, Strathdee D, Tardito S, Gottlieb E, CRUK Rosetta Grand Challenge Consortium, Takats Z, Barry ST, Goodwin RJA, Bunch J, Bushell M, Campbell AD, Sansom OJ 2021 Nature Genetics Oncology ISH/FISH HALO
HIF-independent synthetic lethality between CDK4/6 inhibition and VHL loss across species Nicholson HE, Tariq Z, Housden BE, Jennings RB, Stransky LA, Perrimon N, Signoretti S, Kaelin WG 2019 Cancer Therapy Oncology HALO
Impact of TREM2 risk variants on brain region-specific immune activation and plaque microenvironment in Alzheimer's disease patient brain samples Prokop S, Miller KR, Labra SR, Pitkin RM, Hoxha K, Narasimhan S, Changolkar L, Rosenbloom A, Lee VM-Y, Trojanowski JQ 2019 Acta Neuropathologica Neuroscience Classifier, Area Quantification HALO
ACT1 is required for murine IL-23-induced psoriasiform inflammation potentially independent of E3 ligase activity Lipovsky A, Slivka PF, Su Z, Wang Y, Paulsboe S, Wetter J, Namovic MT, Gauvin D, Perron D, Gauld S, McGaragughty S, Goedken ER 2021 Journal of Investigative Dermatology Immunology Multiplex IHC HALO
Robust and persistent reactivation of SIV and HIV by N-803 and depletion of CD8+ cells McBrien JB, Mavigner M, Li LF, Smith SA, White E, Tharp GK, Walum H, Busman-Suhay K, Aguilera-Sandoval CR, Thayer WO, Spagnuolo RA, Kovarova M, Wahl A, Cervasi B, Margolis DM, Vanderford TH, Carnathan DG, Paiardini M, Lifson JD, Lee JH, Safrit JT, Bosinger SE, Estes JD, Derdeyn CA, Garcia JV, Kulpa DA, Chahroudi A, Silvestri G 2020 Nature Other ISH/FISH HALO
Acute brain inflammation, white matter oxidative stress, and myelin deficiency in a model of neonatal intraventricular hemorrhage Goulding DS, Vogel RC, Gensel JC, Morganti JM, Stromberg AJ, Miller BA 2020 Journal of Neuroscience Immunology, Neuroscience Area Quantification, Object Colocalization HALO
Pharmacologic modulation of RNA splicing enhances anti-tumor immunity Lu S, De Neef E, Thomas J, Sabio E, Rousseau B, Gigoux M, Knorr D, Greenbaum B, Elhanti Y, Hogg S, Chow A, Ghosh A, Xie A, Zamarin D, Cui D, Erickson C, Singer M, Cho H, Wang E, Lu B, Durham B, Shah H, Chowell D, Gabel A, Shen Y, Liu J, Jin J, Rhodes M, Taylor R, Molina H, Wolchok J, Merghoub T, Diaz Jr. L, Abdel-Wahab O, Bradley B 2021 Cell Oncology Multiplex IHC HALO
CTLA-4 and PD-1 dual blockade induces SIV reactivation without control of rebound after antiretroviral therapy interruption Harper J, Gordon S, Chan CN, Wang H, Lindemuth E, Galardi C, Falcinelli SD, Raines SLM, Read JL, Nguyen K, McGary CS, Nekorchuk M, Busman-Sahay K, Schawalder J, King C, Pino M, Micci L, Cervasi B, Jean S, Sanderson A, Johns B, Koblansky AA, Amrine-Madsen H, Lifson J, Margolis DM, Silvestri G, Bar KJ, Favre D, Estes JD, Paiardini 2020 Nature Medicine Immunology, Infectious Disease Cytonuclear, ISH/FISH HALO
Spatially organized multicellular immune hubs in human colorectal cancer Pelka K, Hofree M, Chen J, Sarkizova S, Pirl J, Jorgji V, Bejnood A, Dionne D, Ge W, Xu K, Chao S, Zollinger D, Lieb D, Reeves J, Fuhrman C, Hoang M, Delorey T, Nguyen L, Waldman J, Klapholz M, Wakiro I, Cohen O, Albers, J, Smillie C, Cuoco M, Wu J, Su M, Yeung J, Vijaykumar B, Magnuson A, Asinovski N, Moll T, Goder-Reise M, Applebaum A, Brais L, DelloStritto L, Denning S, Phillips S, Hill E, Meehan J, Frederick D, Sharova T, Kanodia A, Todres E, Jane-Valbuena J, Biton M, Izar B, Lambden C, Clancy T, Bleday R, Melnitchouk N, Irani J, Kunitake H, Berger D, Srivastava A, Hornick J, Ogino S, Rotem A, Vigneau S, Johnson B, Corcoran R, Sharpe A, Kuchroo V, Ng K, Giannakis M, Nieman L, Boland G, Arguirre A, Anderson A, Rosenblatt-Rosen O, Regev A, Hachohen N 2021 Cell Oncology Spatial Analysis, Highplex FL HALO
Hepatic stellate cells suppress NK cell-sustained breast cancer dormancy Correia A Guimaraes J, Auf der Maur P, et al. 2021 Nature Immuno-oncology Classifier HALO
Analysis of multispectral imaging with the AstroPath platform informs efficacy of PD-1 blockade Berry S, Giraldo N, Green B, et al 2021 Science Immuno-oncology HALO
Cabozantinib for neurofibromatosis type 1ñrelated plexiform neurofibromas: a phase 2 trial Fisher MJ, Shih C-S, Rhodes SD, Armstrong AE, Wolters PL, Dombi E, Zhang C, Angus SP, Johnson GL, Packer RJ, Allen JC, Ullrich NJ, Goldman S, Gutmann DH, Plotkin SR, Rosser T, Robertson KA, Widemann BC, Smith AE, Bessler WK, He Y, Park S-J, Mund JA, Jiang L, Bijangi-Vishehsaraei K, Robinson CT, Cutter GR, Korf BR, Neurofibromatosis Clinical Trials Consortium, Blakeley JO, Clapp DW 2021 Nature Medicine Oncology Area Quantification HALO
Olaparib and durvalumab in patients with germline BRCA-mutated metastatic breast cancer (MEDIOLA): an open-label, multicentre, phase 1/2, basket study Domchek SM, Postel-Vinay S, Im S-A, Park YH, Delord J-P, Italiano A, Alexandre J, You B, Bastian S, Krebs MG, Wang D, Waqar SN, Lanasa M, Rhee J, Gao H, Rocher-Ros V, Jones EV, Gulati S, Coenen-Stass A, Kozarewa I, Lai Z, Angell HK, Opincar L, Herbolsheimer P, Kaufman B 2020 The Lancet Oncology Oncology Multiplex IHC HALO
Artificial Intelligence-Based Quantification of Epithelial Proliferation in Mammary Glands of Rats and Oviducts of GÀÜttingen Minipigs Hvid H, Skydsgaard M, Jensen NK, Vluff BM, Jensen HE, Oleksiewicz MB, Kvist PH 2020 Toxicologic Pathology Toxicology Area Quantification HALO AI
Interplay of somatic alterations and immune infiltration modulates response to PD-1 blockade in advanced clear cell renal cell carcinoma Braun DA, Hou Y, Bakouny Z, Ficial M, Sant' Angelo M, Forman J, Ross-Macdonald P, Berger AC, Jegede OA, Elagina L, Steinharter J, Sun M, Wind=Rotolo M, Pignon J-C, Cherniack AD, Lichtenstein L, Neuberg D, Catalano P, Freeman GJ, Sharpe AH, McDermott DF, Van Allen EM, Signoretti S, Wu CJ, Shukla SA, Choueiri TK 2020 Nature Medicine Immuno-oncology Highplex FL, Partitions (tiles, margins) HALO
ARID1A influences HDAC1/BRD4 activity, intrinsic proliferative capacity and breast cancer treatment response Nagarajan S, Rao SV, Sutton J, Cheeseman D, Dunn S, Papachristou EK, Prada J-EG, Couturier D-L, Kumar S, Kishore K, Chilamakuri CSR, Glont E, Goode EA, Brodie C, Guppy N, Natrajan R, Bruna A, Caldas C, Russel A, Siersbaek R, Yusa K, Chernukhin I, Carroll JS 2020 Nature Genetics Oncology Multiplex IHC HALO
Preoperative ipilimumab plus nivolumab in locoregionally advanced urothelial cancer: the NABUCCO trial van Dijk N, Gil-Jimenez A, Silina K, Hendricksen K, Smit LA, de Feijter JM, van Montfoort ML, van Rooijen C, Peters D, Broeks A, van der Poel HG, Bruining A, Lubeck Y, Sikorska K, Boellaard TN, Kvistborg P, Vis DJ, Hooijberg E, Schumacher TN, van den Broek M, Wessels LFA, Blank CU, van Rhijn BW, van der Heijden MS 2020 Nature Medicine Immuno-oncology Classifier, Highplex FL HALO
Immunogenic Chemotherapy Enhances Recruitment of CAR-T Cells to Lung Tumors and Improves Antitumor Efficacy when Combined with Checkpoint Blockade Srivastava S, Furlan SN, Jaeger-Ruckstuhl CA, Sarvothama M, Berger C, Smythe KS, Garrison SM, Specht JM, Lee SM, Amezquita RA, Voillet V, Muhunthan V, Yechan-Gunja S, Pillai SPS, Rader C, Houghton AM, Pierce RH, Gottardo R, Maloney DG, Riddell SR 2020 Cancer Cell Immuno-oncology Multiplex IHC, Highplex FL HALO
HIV-1-induced cytokines deplete homeostatic innate lymphoid cells and expand TCF7-dependent memory NK cells Wang Y, Lifschitz L, Gellatly K, Vinton CL, Busman-Sahay K, McCauley S, Vangala P, Kim K, Derr, Jaiswall S, Kucukural A, McDonel P, Hunt PW, Greenough T, Houghton J, Somsouk M, Estes JD, Brenchley JM, Garber M, Deeks SG, Luban J 2020 Nature Immunology Immunology, Infectious Disease Area Quantification, Cytonuclear, ISH/FISH HALO
IL6/STAT3 Signaling Hijacks Estrogen Receptor ? Enhancers to Drive Breast Cancer Metastasis SiersbÊk R, Scabia V, Nagarajan S, Chernukhin I, Papachristou EK, Broome R, Johnston SJ, Joosten SEP, Green AR, Kumar S, Jones J, Omarjee S, Alvarez-Fernandez R, Glont S, Aitken SJ, Kishore K, Cheeseman D, Rakha EA, D'Santos C, Zwart W, Ruseel A, Brisken C, Carroll JS 2020 Cancer Cell Oncology Area Quantification, Multiplex IHC HALO
Multimodal treatment combining cold atmospheric plasma and acidic fibroblast growth factor for multi?tissue regeneration Tan F, Rui X, Xiang X, Yu Z, Al-Rubeai M 2021 The FASEB Journal Other Multiplex IHC HALO
Promyelocytic leukemia protein promotes the phenotypic switch of smooth muscle cells in atherosclerotic plaques of human coronary arteries Karle W, Becker S, Stenzel P, Knosalla C, Siegel G, Baum O, Zakrzewicz A, Berkholz J 2021 Clinical Science Myology Area Quantification, Object Colocalization HALO
The Unfolded Protein Response Mediator PERK Governs Myeloid Cell-Driven Immunosuppression in Tumors through Inhibition of STING Signaling Mohamed E, Sierra RA, Trillo-Tinoco J, Cao Y, Innamarato P, Payne KK, Pulido M, Mandula J, Zhang S, Thevenot P, Biswas S, Abdalla SK, Costich TL, Hanggi K, Anadon CM, Flores ER, Haura EB, Mehrotra, Pilon-Thomas S, Ruffel B, Munn DH, Cubillos-Ruiz JR, Conejo-Garcia JR, Rodriguez PC 2020 Immunity Immuno-oncology Highplex FL HALO
Genomic analysis of Vascular Invasion in Hepatocellular Carcinoma (HCC) Reveals Molecular Drivers and Predictive Biomarkers Krishnan MS, Rajan KD A, Park J, Arjunan V, Marques FJG, Bermudez A, Girvan OA, Hoang NS, Yin J, Nguyen MH, Kothary N, Pitteri S, Felsher DW, Dhanasekaran R 2020 Hepatology Oncology Multiplex IHC, TMA HALO
Dynamic Hydrogels for Prevention of Post?Operative Peritoneal Adhesions Stapleton LM, Lucian HJ, Grosskopf AK, Smith AAA, Totherow KP, Woo YJ, Appel EA 2021 Advanced Therapeutics Biomaterials Area Quantification HALO
Efficacy and safety of a 3?in?1 antiaging night facial serum containing melatonin, bakuchiol, and ascorbyl tetraisopalmitate through clinical and histological analysis Goldberg DJ, Mraz-Robinson D, Granger C 2020 Journal of Cosmetic Dermatology Dermatology Area Quantification, Layer Thickness HALO
ILC2-driven innate immune checkpoint mechanism antagonizes NK cell antimetastatic function in the lung Schuijs MJ, Png S, Richard AC, Tsyben A, Hamm G, Stockis J, Garcia C, Panaud S, Nicholls A, Ros XR, Su J, Eldridge MD, Riedel A, Serrao EM, Rodewald H-R, Mack M, Shields JD, Cohen ES, McKenzie ANJ, Goodwin RJA, Brindle KM, Marioni JC, Halim TYF 2020 Nature Immunology Immuno-oncology Multiplex IHC HALO
Engineering functional microvessels in synthetic polyurethane random-pore scaffolds by harnessing perfusion flow Wright MEE, Yu JK, Jain D, Maeda A, Yeh S-CA, DaCosta RS, Lin CP, Santerre JP 2020 Biomaterials Biomaterials Area Quantification HALO
Blockade of the co-inhibitory molecule PD-1 unleashes ILC2-dependent antitumor immunity in melanoma Jacquelot N, Seillet C, Wang M et al. 2021 Nature Immunology Immuno-oncology Classifier, Highplex FL HALO
Expansion of Immature, Nucleated Red Blood Cells by Transient Low?Dose Methotrexate Immune Tolerance Induction in Mice Tran JQ, Grover D, Zhang M, Stapels M, Brennan R, Bangari DS, Piepenhagen PA, Roberts E, Olivia P, Zubair F, Vela JL, Richards SM, Joseph AM 2020 Clinical & Experimental Immunology Immunology Area quantification HALO
The InSituPlexÆ Staining Method for Multiplexed Immunofluorescence Cell Phenotyping and Spatial Profiling of Tumor FFPE Samples Manesse M, Patel KK, Bobrow M, Downing SR 2020 Biomarkers for Immunotherapy of Cancer Oncology, Immuno-oncology Highplex FL HALO
Highly efficient genome editing in primary human bronchial epithelial cells differentiated at air-liquid interface Rapiteanu R, Karagyozova T, Zimmerman N, Singh K, Wayne G, Martufi M, Belyaev NN, Hessel EM, Michalovich D, Macarron R, Rowan WC, Cairns WJ, Roger J, Betts J, Beinke S, Maratou K 2020 European Respiratory Journal Other Highplex FL HALO
IBI112, a selective anti-IL23p19 monoclonal antibody, displays high efficacy in IL-23-induced psoriasiform dermatitis Li L, Wu Z, Qiu X, Wu Y, Kuang Z, Wang L, Sun T, Liu Y, Yi S, Jing H, Zhou S, Chen B, Wu, D, Wu W, Liu J 2020 International Immunopharmacology Immunology, Dermatology Classifier, Layer Thickness HALO
A four-chemokine signature is associated with a T cell-inflamed phenotype in primary and metastatic pancreatic cancer Romero JM, Gr¸nwald BT, Jang G-H, Bavi PP, Jhaveri A, Masoomian M, Fischer SE, Zhang A, Denroche RE, Lungu IM, De Luca A, Bartlett JMS, Xu J, Li N, Dhaliwal S, Liang S-B, Chadwick D, Vyas F, Bronsert P, Khokha R, McGaha TL, Notta F, Ohashi PS, Done SJ, O'Kane GM, Wilson JM, Knox JJ, Connor A, Wang Y, Zogopoulos G, Gallinger S 2020 Clinical Cancer Research Oncology Immune HALO
A Dedicated Evolutionarily Conserved Molecular Network Licenses Differentiated Cells to Return to the Cell Cycle Miao Z-F, Lewis MA, Cho CJ, Adkins-Threats M, Park D, Brown JW, Sun J-X, Burclaff JR, Kennedy S, Lu J, Mahar M, Vietor I, Huber LA, Davidson NO, Cavalli V, Rubin DC, Wang Z-N, Mills JC 2020 Developmental Cell Oncology Highplex FL HALO
Mobilization of CD8+ T cells via CXCR4 blockade facilitates PD-1 checkpoint therapy in human pancreatic cancer Seo YD, Jiang X, Sullivan KM, Jalikis FG, Smythe KS, Abbasi A, Vignali M, Park JO, Daniel SK, Pollack SM, Kim TS, Yeung R, Crispe IN, Pierce RH, Robins H, Pillarisetty VG 2019 Clinical Cancer Research Immuno-oncology Cytonuclear HALO
STAT3 antisense oligonucleotide remodels the suppressive tumor microenvironment to enhance immune activation in combination with anti-PD-L1 Proia T, Singh M, Woessner R, Carnevalli LS, Bommakanti G, Magiera L, Srinivasan SS, Grosskurth SE, Collins M, Womack C, Griffin M, Ye M, Cantin S, Russell DL, Xie M, Hughes AM, Deng N, Mele DA, Fawell SE, Barry ST, Reimer C, Barrett JC, McCoon P 2020 Clinical Cancer Research Immuno-oncology Multiplex IHC, Highplex FL HALO
Imaging Tumor-Infiltrating Lymphocytes in Brain Tumors with [64Cu]Cu-NOTA-anti-CD8-Positron Emission Tomography Nagle V, Henry K, Hertz C, et al. 2021 Clinical Cancer Research Immuno-oncology Multiplex IHC HALO
Cooperative targeting of immunotherapy-resistant melanoma and lung cancer by an AXL-targeting antibody-drug conjugate and immune checkpoint blockade Boshuizen J, Pencheva N, Krijgsman O, Altimari DD, Castro PG, de Bruijn B, Ligtenberg MA, den Heuvel EG, Vredevoogd DW, Song J-Y, Visser N, Apriamashvili G, Janmaat ML, Plantinga TS, Franken P, Houtkamp M, Lingnau A, Jure-Kunkel M, Peeper DS 2021 Cancer Research Immuno-oncology Multiplex-IHC HALO
Over-expression of Th2-related molecules in the skin of patients with eosinophilic dermatosis of hematologic malignancy Maglie R, Ugolini F, De Logu F, Nassini R, Simi S, Nardiello P, Pasqualaini E, Baroini G, Del Bianco E, Massi D, Antiga E 2021 Journal of the American Academy of Dermatology Oncology, Immuno-oncology Area Quantification, Multiplex IHC HALO Link
Temporal Analysis of Amylase Expression in Control, Autoantibody Positive, and Type 1 Diabetes Pancreatic Tissues Kusmartseva I, Beery M, Hiller H, Padilla M, Selman S, Posgai A, Nick HS, Campbell-Thompson M, Schatz DA, Haller MJ, Wasserfall CH, Atkinson MA 2019 Diabetes Metabolism Cytonuclear HALO
Kras and Lkb1 mutations synergistically induce intraductal papillary mucinous neoplasm derived from pancreatic duct cells Collet L, Ghurburrun E, Meyers N, Assi M, Pirlot B, Leclercq IA, Couvelard A, Komuta M, Cros J, Demetter P, Lemaigre FP, Borbath I, Jacquemin P 2019 Gut Oncology Area Quantification HALO
Prognostic features of the tumour microenvironment in oesophageal adenocarcinoma McShane R, Arya S, Stewart A, Caie P, Bates M 2021 Biochimica et Biophysica Acta (BBA) - Reviews on Cancer Immuno-oncology, Review Cytonuclear HALO
Mammalian Retinal Cell Quantification Muthuswamy A, Chen H, Hu Y, Turner OC, Aina OH 2020 Toxicologic Pathology Other Cytonuclear HALO
Cx43 phosphorylation sites regulate pancreatic cancer metastasis Solan JL, Hingorani SR, Lampe PD 2021 Oncogene Oncology Classifier, Area Quantification HALO
MAOA-mediated reprogramming of stromal fibroblasts promotes prostate tumorigenesis and cancer stemness Li J, Pu T, Yin L, Li Q, Liao C-P, Wu BJ 2020 Oncogene Oncology Multiplex IHC HALO
Multimodal In Vivo and Post-mortem Assessments of Tau in Lewy Body Disorders Coughlin DG, Phillips JS, Roll E, Peterson C, Lobrovich R, Rascovsky K, Ungrady M, Wolk DA, Das S, Weintraub D, Lee EB, Trojanowski JQ, Shaw LM, Vaishnavi S, Siderowf A, Nasrallah IM, Irwin DJ, McMillan CT 2020 Neurobiology of Aging Neuroscience Area Quantification HALO
B7-H3 immune checkpoint expression is a poor prognostic factor in colorectal carcinoma Lu Z, Zhao Z-X, Cheng P, Huang F, Guan X, Zhang M-G, Chen H-P, Liu Z, Jiang Z, Zheng Z-X, Zou S-M, Wang X-S 2020 Modern Pathology Immuno-oncology Multiplex-IHC, TMA HALO
Chemoradiotherapy efficacy is predicted by intra-tumour CD8+/FoxP3+ double positive T cell density in locally advanced N2 nonñsmall-cell lung carcinoma Boulle G, Velut Y, Mansuet-Lupo A, Gibault L, Blons H, Fournel L, Boni A, Cremer I, Wislez M, Duchatelle V, Tredaniel J, Hammond SA, Herbst R, Alifano M, Giraud P, Damotte D 2020 European Journal of Cancer Oncology Highplex FL HALO
Neonatal hydrocephalus leads to white matter neuroinflammation and injury in the corpus callosum of Ccdc39 hydrocephalic mice Goulding DS, Vogel RC, Pandya CD, Shula C, Gensel JC, Mangano FT, Goto J, Miller BA 2020 Journal of Neurosurgery Immunology, Neuroscience Multiplex IHC, Highplex FL HALO
The RAC1 target NCKAP1 plays a crucial role in progression of BRAF/PTEN -driven melanoma in mice Swaminathan K, Campbell A, Papalazarou V, Jaber-Hijazi F, Nixon C, McGhee E, Strathdee D, Sansom OJ, Machesky LM 2020 Journal of Investigative Dermatology Oncology, Dermatology Area Quantification, Multiplex IHC HALO
Intraductal pancreatic cancer is less responsive than cancer in the stroma to neoadjuvant chemotherapy Fujikura K, Hutchings D, Braxton AM, Zhu Q, Laheru DA, Hruban RH, Thompson ED, Wood LD 2020 Modern Pathology Oncology Multiplex IHC HALO
Phosphorylation of connexin 43 at MAPK, PKC or CK1 sites each distinctly alter the kinetics of epidermal wound repair Lastwika JK, Dunn CA, Solan JL, Lampe PD 2019 Journal of Cell Science Dermatology Cytonuclear HALO
T-regulatory cells predict clinical outcome in soft tissue sarcoma patients: a clinico-pathological study Smolle M, Herbsthofer L, Granegger B, Goda M, Brcic I, Bergovec M, Scheipl S, Prietl B, Pichler M, Gerger A, Rossmann C, Riedl J, Tomberger M, LÛpez-GarcÌa P, El-Heliebi A, Leithner A, Liegl-Atzwanger B, Szkandera J 2021 British Journal of Cancer Oncology Highplex FL, TMA HALO
Quantitative digital image analysis of tumor-infiltrating lymphocytes in HER2-positive breast cancer Abe N, Matsumoto H, Takamatsu R, Tamaki K, Takigami N, Uehara K, Kamada Y, Tamaki N, Motonari T, Unesoko M, Nakada N, Zaha N, Zaha H, Yoshimi N 2019 Vichows Archiv Oncology Classifier, Cytonuclear HALO
RNA isoform screens uncover the essentiality and tumor-suppressor activity of ultraconserved poison exons Thomas JD, Polaski JT, Feng Q, De Neef EJ, Hoppe ER, McSharry MV, Pangallo J, Gabel AM, Belleville AE, Watson J, Nkinsi NT, Berger AH, Bradley RK 2020 Nature Genetics Other Highplex FL HALO
Glucagon Receptor Inhibition Reduces Hyperammonemia and Lethality in Male Mice with Urea Cycle Disorder Cavino K, Sung B, Su Q, Na E, Kim J, Cheng X, Gromada J, Okamoto H 2020 Endocrinology Metabolism ISH/FISH, Multiplex IHC HALO
Characterization of the tumor immune microenvironment in human papillomavirus-positive and -negative head and neck squamous cell carcinomas Succaria F, Kvistborg P, Stein JE, Engle EL, McMiller TL, Rooper LM, Thompson E, Berger AE, van den Brekel M, Zuur CL, Haanen J, Topalian SL, Taube JM 2020 Cancer Immunology, Immunotherapy Immuno-oncology Immune HALO
Temporospatial Development of Neuropathologic Findings in a Canine Model of Mucopolysaccharidosis IIIB Harm TA, Hostetter SJ, Nenninger AS, Valentine BN, Ellinwood NM, Smith JD 2020 Veterinary Pathology Immunology, Neruoscience Area Quantification, Cytonuclear HALO
Development of a clinically relevant ovarian cancer model incorporating surgical cytoreduction to evaluate treatment of micro-metastatic disease Morse CB, Voillet V, Bates BM, Chiu EY, Garcia NM, Gottardo R, Greenberg PD, Anderson KG 2020 Gynecologic Oncology Oncology Multiplex IHC HALO
PIK3CA mutation and CNV status and post-chemoradiotherapy survival in patients with cervical cancer Martell K, McIntyre JB, Kornaga EN, Chan AMY, Phan T, Kobel M, Enwere EK, Dean ML, Ghatage P, Lees-Miller SP, Doll CM 2020 Gynecologic Oncology Oncology Classifier, Highplex FL, TMA HAO
Tumor Platinum Concentrations and Pathological Responses Following Cisplatin-Containing Chemotherapy in Gastric Cancer Patients Cao Y, Chang Q, Cabanero M, Zhang W, Hafezi-Bakhtiari S, Hedley D, Darling G, Quereshy F, Jang R, Elimova E, Knox J, Ornatsky O, Serra S, Chen E 2019 Journal of Gastrointestinal Cancer Oncology Area Quantification, Cytonuclear HALO
PLX3397 treatment inhibits constitutive CSF1R-induced oncogenic ERK signaling, reduces tumor growth, and metastatic burden in osteosarcoma Smeester BA, Slipek NJ, Pomeroy EJ, Laoharawee K, Osum SH, Larsson AT, Williams KB, Stratton N, Yamamoto K, Peterson JJ, Rathe SK, Mills LJ, Hudson WA, Crosby MR, Wang M, Rahramann EP, Moriarity SB, Largaespada DA 2020 Bone Oncology Cytonuclear, TMA HALO
IFN-III is selectively produced by cDC1 and predicts good clinical outcome in breast cancer Hubert M, Gobbini E, Couillault C, Manh T-PV, Doffin A-C, Berthet J, Rodriguez C, Ollion V, Kielbassa J, Sajous C, Treilleux I, Tredan O, Dubois B, Dalod M, Bendriss-Vermare N, Caux C, Valladeau-Guilemond J 2020 Immunology Oncology Highplex FL, Partitions (tiles, margins) HALO
Using immuno-PET imaging to monitor kinetics of T cell-mediated inflammation and treatment efficiency in a humanized mouse model for GvHD Pektor S, SchlÀÜder J, Klasen B, Bausbacher N, Wagner D-C, Schreckenberger W, Grabbe S, Jonuleit H, Miederer M 2019 European Journal of Nuclear Medicine and Molecular Imaging Immunology Cytonuclear HALO
Association between CD8 and PD?L1 expression and outcomes after radical prostatectomy for localized prostate cancer Vicier C, Ravi P, Kwak L, Werner L, Huang Y, Evan C, Loda M, Hamid AA, Sweeney CJ 2020 The Prostate Immuno-oncology Classifier, Highplex FL HALO
?-Synuclein modulates tau spreading in mouse brains Bassil F, Meymand ES, Brown HJ, Xu H, Cox TO, Pattabhiraman S, Maghames CM, Wu Q, Zhang B, Trojanowski JQ, Lee VM-Y 2020 Journal of Experimental Medicine Neuroscience Area Quantification HALO
A locus coeruleus to dentate gyrus noradrenergic circuit modulates aversive contextual processing Seo D, Zhang E, Piantadosi S, et al 2021 Neuron Neuroscience Area Quantification, Highplex FL HALO
Clinicopathological significance of nerves in esophageal cancer Griffin N, Rowe CW, Gao F, Jobling P, Wills V, Walker MM, Faulkner S, Hondermarck H 2020 The American Journal of Pathology Oncology Area Quantification HALO
AST-120 Treatment Alters the Gut Microbiota Composition and Suppresses Hepatic Triglyceride Levels in Obese Mice Hiraga Y, Kubota T, Katoh, M, et al. 2021 Endocrine Research Metabolism Vacuole HALO
High CD8+ tumour infiltrating lymphocyte density associates with unfavourable prognosis in oesophageal adenocarcinoma following poor response to neo?adjuvant chemoradiotherapy Koemans WJ, van Dieren JM, van den Berg J, Meijer G, Snaebjornsson P, Chalabi M, Lecot F, Riedl R, Krijgsman O, Hofland I, Broeks A, Voncken FEM, Peppelenbosch MP, Sosef MN, van Sandick JW, Kodach LL 2021 Histopathology Immuno-oncology Cytonuclear HALO
High density of cytotoxic T-lymphocytes is linked to tumoral PD-L1 expression regardless of the mismatch repair status in colorectal cancer MÀÜller K, Blessin N, HÀÜflmayer D, et al. 2021 Acta Oncologica Immuno-oncology Highplex FL HALO
Discoidin Domain Receptor 1 (DDR1) is Necessary for Tissue Homeostasis in Pancreatic Injury and Pathogenesis of Pancreatic Ductal Adenocarcinoma Ruggeri JM, Franco-Barraza J, Sohail A, Zhang Y, Long D, di Magliano MP, Cukierman E, Fridman R, Crawford HC 2020 The American Journal of Pathology Oncology, Immunology Cytonuclear, Multiplex IHC, Highplex FL HALO
Chronic stress differentially alters mRNA expression of opioid peptides and receptors in the dorsal hippocampus of female and male rats Johnson MA, Contoreggi NH, Kogan JF, Bryson M, Rubin BR, Gray JD, Kreek MJ, McEwen BS, Milner TA 2021 The Journal of Comparative Neurology Neruoscience ISH/FISH HALO
Monocyte and macrophage derived myofibroblasts: Is it fate? A review of the current evidence Vierhout M, Ayoub A, Naiel S, Yazdanshenas P, Revill S, Reihani A, Dvorkin-Gheva A, Shi W, Ask K 2021 Wound Repair and Regeneration Review ISH/FISH HALO
Necroptosis in biliary atresia of the liver Hashimoto M, Fujishima F, Lomphithak T, Jitkaew S, Nio M, Sasano H 2021 Medical Molecular Morphology Metabolism Multiplex IHC HALO
Intracranial administration of alpha-synuclein fibrils in A30P-synuclein transgenic mice causes robust synucleinopathy and microglial induction Gentzel R, Toolan D, Jinn S, Schachter J, Ma L, Kahle P, Smith S, Marcus J 2021 Neurobiology of Aging Neuroscience Area Quantification HALO
A comparative study of cirrhosis sub-staging using the Laennec system, Beijing classification, and morphometry Zhang X, Schiano T, Doyle E, Branch A, Florman S, Fiel M. 2021 Modern Pathology Metabolism Classifier, Area Quantification HALO
Alteration of Colonic Mucin Composition and Cytokine Expression in Acute Swine Dysentery Lin S J-H, Arruda B, Burrough E 2021 Veterinary Pathology Immunology Area Quantification, ISH/FISH HALO
Selective loss of resident macrophage-derived insulin-like growth factor-1 abolishes adaptive cardiac growth to stress Zaman R, Hamidzada H, Kantores C, Wong A, Dick S, Wang Y, Momen A, Aronoff L, Lin J, Razani B, Mital S, Billia F, Lavine K, Nejat S, Epelman S 2021 Immunity Immunology Highplex FL HALO
Ki-67 Proliferation Index Assessment in Gastroenteropancreatic Neuroendocrine Tumors by Digital Image Analysis With Stringent Case and Hotspot Level Concordance Requirements Boukhar SA, Gosse MD, Bellizzi AM, Rajan A 2021 American Journal of Clinical Pathology Oncology Cytonuclear HALO
Establishing standardized immune phenotyping of metastatic melanoma by digital pathology Sobottka B, Nowak M, Frei A, Haberecker M, Merki S, Tumor Profiler consortium, Levesque M, Dummer R, Moch H, Koelzer V 2021 Laboratory Investigation Immuno-oncology Multiplex IHC, Spatial Analysis HALO AI
Orexin receptors 1 and 2 in serotonergic neurons differentially regulate peripheral glucose metabolism in obesity Xiao X Yeghiazaryan G, Hess S, Klemm P, Sieben A, Kleinridders A, Morgan D, Wunderlich F. Rahmouni K. Kong D, Scammell T, Lowell B, Kloppenburg P, Br¸ning J, Hausen A. 2021 Nature Communications Metabolism ISH/FISH HALO
Simultaneous targeting of TGF-b/PD-L1 synergizes with radiotherapy by reprogramming the tumor microenvironment to overcome immune evasion Lan Y, Moustaga M, Knoll M, Xu C, Furkel J, Lazorchak A, Yeung T, Hasheminasab S, Jenkins M, Meister S, Yu H, Schlegel J, Marelli B, Tang Z, Qin G, Klein C, Qi J, Zhou C, Locke G, Krunic D, Derner M, Schwager C, Fontana R, Kriegsmann K, Jiang F, Rein K, Kriegsmann M, Debus J, Lo K, Abdollahi A 2021 Cancer Cell Oncology Cytonuclear HALO
SLFN11 captures cancer-immunity interactions associated with platinum sensitivity in high-grade serous ovarian cancer Winkler C, King M, Berthe J, Ferraioli D, Garuti A, Grillo F, Rodriguez-Canales J, Ferrando L, Chopin N, Ray-Coquard I, Delpuech O, Bedognetti D, Ballestrero A, Leo E, Zoppoli G 2021 JCI Insight Oncology Classifier, Cytonuclear HALO
Three subtypes of lung cancer fibroblasts definedistinct therapeutic paradigms Hu H, Peotrowska Z, Hare P, Chen H, Mulvey H, Mayfield A, Noeen S, Kattermann K, Greenberg M, Williams A, Riley A, Wilson J, Mao Y, Huang R, Banwait M, Ho J, Crowther G, Hariri L, Sequist L, Benes C, Niederst M, Engelman J 2021 Cancer Cell Oncology Cytonuclear, ISH/FISH HALO
NR4A1†regulates expression of immediate early genes, suppressing replication stress in cancer Guo H, Golczer G, Wittner B, Langenbucher A, Zachariah M, Dubash T, Hong X, Comaills V, Burr R, Ebright R, Horwitz E, Vuille J, Hajizadeh S, Wiley D, Reeves B, Zhang J, Niederhoffer K, Lu C, Wesley B, Ho U, Nieman L, Toner M, Vasudevan S, Zou L, Mostoslavsky R, Maheswaran S, Lawrence M, Haber D 2021 Molecular Cell Oncology Highplex FL HALO
AG-205 Upregulates Enzymes Involved in Cholesterol Biosynthesis and Steroidogenesis in Human Endometrial Cells Independently of PGRMC1 and Related MAPR Proteins Thieffry C, Van Wynendaele M, Aynaci A, Maja M, Dupuis C, Loriot A, Marbaix E, Henriet P 2021 Biomolecules Other Cytonuclear, Highplex FL HALO
p53-mediated redox control promotes liver regeneration and maintains liver function in response to CCl4 Humpton T, Hall H, Kiourtis C, Nixon C, Clark W, Hedley A, Shaw R, Bird T, Blyth K, Vousden K 2021 Cell Death & Differentiation Metabolism Cytonuclear, Multiplex IHC HALO
Single-cell RNA transcriptome landscape of hepatocytes and non-parenchymal cells in healthy and NAFLD mouse liver Su Q, Kim S, Adewale F, Zhou Y, Alder C, Ni M, Wei Y, Burcznski M, Atwal G, Sleeman M, Murphy A, Xin Y, Cheng X 2021 iScience Metabolism Area Quantification HALO
Functional heterogeneity of POMC neurons relies on mTORC1 signaling Saucisse N, Mazier W, Simon V, Binder E, Catania C, Bellocchio L, Romanov R, Leon S, Matias I, Zizzari P, Quarta C, Cannich A, Meece K, Gonzales D, Clark S, Becker J, Yeo G, Fioramonti X, Merkle F, Wardlaw S, Harkany T, Massa F, Marsicano G, Cota D 2021 Cell Reports Neuroscience ISH/FISH HALO
Atypical chemokine receptor 3 (ACKR3) induces the perturbation of rRNA biogenesis in colonic cells: a novel mechanism of colorectal tumorigenesis Yang J, Li Y, Pan T, Miao R, Zhang Y, Wu S, Qu X, Cui S 2021 Research Square Oncology Area Quantification HALO
IL-1-driven stromalñneutrophil interactions define a subset of patients with inflammatory bowel disease that does not respond to therapies Friedrich M, Pohin M, Jackson M, Korsunsky I, Bullers S, Rue-Albrecht K, Christoforidou Z, Sathananthan D, Thomas T, Ravindran R, Tandon R, Peres R, Sharpe H, Wei K, Watts G, Mann E, Geremia A, Attar M, Oxford IBD Cohort Investigators, Roche Fibroblast Network Consortium, McCuaig S, Thomas L, Collantes E, Uhlig H, Sansom S, Easton A, Raychaudhuri S, Travis S, Powrie F 2021 Nature Medicine Gastroenterology Cytonuclear HALO
Increased IL-6 expression precedes reliable viral detection in the rhesus macaque brain during acute SIV infection Gopalakrishnan R, Aid M, Mercado N, Davis C, Malik S, Geiger E, Varner V, Jones R, Bosinger S, Piedra-Mora C, Martinot A, Barouch D, Reeves R, Tan C 2021 JCI Insight Infectious Disease Area Quantification HALO
Combined CTLA-4 and PD-L1 blockade in patients with chemotherapy-naÔve metastatic castration-resistant prostate cancer is associated with increased myeloid and neutrophil immune subsets in the bone microenvironment Subudhi S, Siddiqui B, Aparicio A, Yadav S, Basu S, Chen H, Jindal S, Tidwell R, Varma A, Logothetis C, Allison J, Corn P, Sharma P 2021 Journal for ImmunoTherapy of Cancer Immuno-oncology Cytonuclear, Multiplex IHC HALO
Expression of SARS-CoV-2 Entry Factors in the Pancreas of Normal Organ Donors and Individuals with COVID-19 Kusmartseva I, Wu W, Syed F, Van Der Heide V, Jorgensen M, Joseph P, Tang X, Candelario-Jalil E, Yang C, Nick H, Harbert J, Posgai A, Paulsen J, Lloyd R, Cechin S, Pugliese A, Campbell-Thomson M, Vander Heide R, Evans-Molina C, Homann D, Atkinson M 2020 Cell Metabolism Infectious Disease Area Quantification HALO
Baricitinib Treatment Resolves Lower-Airway Macrophage Inflammation and Neutrophil Recruitment in Sars-Cov-2-Infected Rhesus Macaques Hoang T, Pino M, Boddapati A, Viox E, Starke C, Upadhyay A, Gumber S, Nekorchuk M, Busman-Sahay K, Strongin Z, Harper J, Tharp G, Pellegrini K, Kirejczyk S, Zandi K, Tao S, Horton T, Beagle E, Mahar E, Lee M, Cohen J, Jean S, Wood J, Connor-Stroud F, Stammen R, Delmas O, Wang S, Cooney K, Sayegh M, Wang L, Filev P, Weiskopf D, Silvestri G, Waggoner J, Piantadosi A, Kasturi S, Al-Shakhshir H, Ribeiro S, Sekaly R, Levit R, Estes J, Vanderfold T, Schinazi R, Bosinger S, Paiardine M 2021 Cell Infectious Disease Multiplex IHC HALO
Diagnostic and prognostic implications of a three-antibody molecular subtyping algorithm for non-muscle invasive bladder cancer Jackson C, Chen L, Hardy C, Ren K, Visram K, Bratti V, Johnstone J, SjÀÜdahl G, Siemens D, Gooding R, Berman D 2021 The Journal of Pathology: Clinical Research Oncology Cytonuclear, TMA HALO
Transcriptomic Analysis of Healthy and Atopic Dermatitis Samples Reveals the Role of IL-37 in Human Skin Zhou J, Gemperline D, Turner M, Oldach J, Molignano J, Sims J, Stayrook K 2021 ImmunoHorizons Dermatology Area Quantification, Cytonuclear HALO
Interleukin-33 activates group 2 innate lymphoid cell expansion and modulates endometriosis Miller J, Lingegowda H, Symons L, Bougie O, Young S, Lessey B, Koti M, Tayade C 2021 JCI Insight Other Area Quantification, Cytonuclear HALO
Development of a novel humanized mouse model for improved evaluation of in vivo anti-cancer effects of anti-PD-1 antibody Katano I, Hanazawa A, Otsuka I, Yamaguchi T, Mochizuki M, Kawai K, Ito R, Goto M, Kagawa T, Takahashi T 2021 Scientific Reports Oncology Cytonuclear, Multiplex IHC HALO
A comparability study of natural and deglycosylated PD-L1 levels in lung cancer: evidence from immunohistochemical analysis Mei J, Xu J, Yang X, Gu D, Zhou W, Wang H, Liu C 2021 Molecular Cancer Oncology Cytonuclear, Multiplex IHC HALO
Automated Detection and Classification of Desmoplastic Reaction at the Colorectal Tumour Front Using Deep Learning Nearchou I, Ueno H, Kajiwara Y, Lillard K, Mochizuki S, Takeuchi K, Harrison D, Caie P 2021 Cancers Oncology HALO AI
Mitochondria exert age-divergent effects on recovery from spinal cord injury Stewart A, McFarlane K, Vekaria H, Bailey W, Slone S, Tranthem L, Zhang B, Patel S, Sullivan P, Gensel J 2021 Experimental Neurology Neuroscience Object Colocalization HALO
Large-Section Histopathology Can Better Indicate the Immune Microenvironment and Predict the Prognosis of Pancreatic Ductal Adenocarcinoma Than Small-Section Histopathology Ding G, Guo M, Yang Y, Sun C, Wu S, Liu X, Wang J, Jiang H, Liu Y, Zheng J 2021 Frontiers in Oncology Oncology Multiplex IHC HALO
Androgen Receptor Signalling in Macrophages Promotes TREM-1-mediated Cancer Cell Line Migration and Invasion Cioni B, Zaalberg A, van Beihnum J, Melis M, van Brugsteden J, Muraro M, Hooijberg E, Peters D, Hofland I, Lubeck Y, de Jong J, Sanders J, Vivie J, van der Poel J, Griffioen A, Zwart W, Bergman A 2021 Nature Communications Oncology Highplex FL, Partitions (tiles, margins) HALO
Dysregulation of Innate Lymphoid Cells in Patients with Active Rheumatoid Arthritis and Mice with Collagen-Induced Arthritis Yang F, Luo X, Zhu W, Li J, Zheng Z, Zhu P 2021 Mediators of Inflammation Spatial Analysis, Highplex FL HALO
CD147 antibody specifically and effectively inhibits infection and cytokine storm of SARS-CoV-2 and its variants delta, alpha, beta, and gamma Geng J, Chen L, Yuan Y, Wang K, Wang Y, Qin C, Wu G, Chen R, Zhang Z, Wei D, Du P, Zhang J, Lin P, Zhang K, Deng Y, Xu K, Liu J, Sun X, Guo T, Yang X, Wu J, Jiang J, Li L, Zhang K, Wang Z, Zhang J, Yan Q, Zhu H, Zheng Z, Miao J, Fu X, Yang F, Chen X, Tang H, Zhang Y, Shi Y, Zhu Y, Pei Z, Huo F, Liang X, Wang Y, Wang Q, Xie W, Li Y, Shi M, Bian H, Zhu P, Chen Z 2021 Signal Transduction and Targeted Therapy Infectious Disease Cytonuclear, Multiplex IHC, Highplex FL HALO
Suppression of insulin-induced gene 1 (INSIG1) function promotes hepatic lipid remodelling and restrains NASH progression Azzu V, Vacca M, Kamzolas I, Hall Z, Leslie J, Carobbio S, Virtue S, Davies S, Lukasik A, Dale M, Bohlooly-Y M, Acharjee A, Linden D, Bidault G, Petsalaki E, Griffin J, Oakley F, Allison M, Vidal-Puig 2021 Molecular Metabolism Metabolism Area Quantification, Cytonuclear, Multiplex IHC HALO
An endogenous opioid circuit determines state-dependent appetitive behavior Castro D, Oswell C, Zhang E, Pedersen C, Piantadosi S, Rossi M, Hunker A, Guglin A, Moron J, Zweifel L, Stuber G, Bruchas M 2021 bioRxiv Neuroscience Cytonuclear, Highplex FL HALO
A faithful in vivo model of human macrophages in metastatic melanoma Voillet V, Berger T, McKenna K, Paulson K, Smythe K, Hunter D, Valente W, Weaver S, Campbell J, Kim T, Byrd D, Bielas J, Pierce R, Chapuis A, Gottardo R, Rongvaux 2021 bioRxiv Cytonuclear, Multiplex IHC HALO
Maternal platelets pass interstices of trophoblast columns and are not activated by HLA-G in early human pregnancy Guettler J, Forstner D, Cvirn G, Maninger S, Brugger B Nonn O, Kupper N, Pritz E, Wernitznig S, Dohr G, Hutter H, Juch H, Isermann B, Kohli S, Gauster M 2021 Journal of Reproductive Immunology Other Cytonuclear, Highplex FL HALO
Absolute copy number fitting from shallow whole genome sequencing data Sauer C, Eldridge M, Vias M, Hall J, Boyle S, Macintyre G, Bradley T, Markowetz F, Brenton J 2021 bioRxiv Oncology Classifier HALO
E3 ligase-inactivation rewires CBL interactome to elicit oncogenesis by hijacking RTKñCBLñCIN85 axis Ahmed S, Buetow L, Gabrielsen M, Lilla S, Sibbet G, Sumpton D, Zanivan S, Hedley A, Clark W, Huang D 2021 Oncogene Oncology Cytonuclear, Multiplex IHC HALO
Detection of EpsteinñBarr Virus in Periodontitis: A Review of Methodological Approaches Tonoyan L, Chevalier M, Vincent-Bungnas S, Marsault R, Doglio A 2021 Mircroorganisms Review ISH/FISH, ISH-IHC/FISH-IF HALO
CYRI-A limits invasive migration through macropinosome formation and integrin uptake regulation Le A, Yelland T, Paul N, Fort L, Nikolaou S, Ismail S, Machesky L 2021 Journal of Cell Biology Other Cytonuclear, Multiplex IHC HALO
Structure of the helicase core of Werner helicase, a key target in microsatellite instability cancers Newman J, Gavard A, Lieb S, Ravichandran M, Hauer K, Werni P, Geist L, Bottcher J, Engen J, Rumpel K, Samwer M, Petronczki, Gileadi O 2021 Life Science Alliance Oncology Cytonuclear, Highplex FL HALO
In vitro amplification of pathogenic tau conserves disease-specific bioactive characteristics Xu H, O'Reilly M, Gibbons G, Changolkar L, McBride J, Riddle D, Zhang B, Stieber A, Nirschl J, Kim S, Hoxha K, Brunden K, Schellenberg G, Trojanowski J, Lee V 2021 Acta Neuropathologica Neruoscience Cytonuclear, Multiplex IHC HALO
Cross-linking of T cell to B cell lymphoma by the T cell bispecific antibody CD20-TCB induces IFN?/CXCL10-dependent peripheral T cell recruitment in humanized murine model Cremasco F, Menietti E, Speziale D, Sam J, Sammicheli S, Richard M, Varol A, Klein C, Umana P, Bacac M, Colombetti S, Perro M 2021 PLOS ONE Oncology Cytonuclear, Multiplex IHC, Highplex FL HALO
Tissue-resident FOLR2+ macrophages associate with tumor-infiltrating CD8+ T cells and with increased survival of breast cancer patients Ramos, R, Missolo-Koussou Y, Gerber-Ferder Y, Bromley C, Bugatti M, Nunez N, Tosello J, Richer W, Denizeau J, Sedlik C, Caudana P, Kotsias F, Niborski L, Viel S, Bohec M, Lameiras S, Baulande S, Lesage L, Nicolas A, Mesure D, Vincent-Salomon A, Reyal F, Dutertre C, Ginhoux F, Vimeux L, Donnadieu E, Buttard B, Galon J, Zelenay S, Vermi W, Guermonprez P, Piaggio E, Helft J 2021 bioRxiv Immuno-oncology Cytonuclear, Highplex FL, TMA HALO
CCNE1 amplification is synthetic-lethal with PKMYT1 kinase inhibition Gallo D, Young J, Fourtounis J, Martino G, Alvarez-Quilon A, Bernier C, Duffy N, Papp R, Roulston A, Stocco R, Szychowski J, Veloso A, Alam H, Baruah P, Fortin A, Bowlan J, Chaudhary N, Desjardins J, Dietrich E, Fournier S, Fugere-Desjardins C, de Rugy T, Leclaire M, Liu B, Melo H, Nicolas O, Singhania A, Szilard R, Tkac J, Yin S, Morris S, Zinda M, Marshall C, Duocher D 2021 bioRxiv Other Cytonuclear, Multiplex IHC HALO
MNK inhibition sensitizes KRAS-mutant colorectal cancer to mTORC1 inhibition by reducing eIF4E phosphorylation and c-MYC expression Knight J, Alexandrou C, Skalka G, Vlahov N, Pennel K, Officer L, Teodosio A, Kanellos G, Gay D, May-Wilson S, Smith E, Najumudeen A, Gilroy K, Ridgway R, Flanagan D, Smith R, McDonald L, MacKay C, Cheasty A, McArthur K, Stanway E, Leach J, Jackstadt R, Waldron J, Campbell A, Vlachogiannis G, Valeri N, Haigis K, Sonenberg N, Proud C, Jones N, Swarbrick M, McKinnon H, Faller W, LeQuense J, Edwards J, Willis A, Bushell M, Sansom O 2021 Cancer Discovery Oncology Cytonuclear, Highplex FL HALO
Computational modeling of tau pathology spread reveals patterns of regional vulnerability and the impact of a genetic risk factor Cornblath E, Li H, Changolkar C, Zhang B, Brown H, Gathagan R, Olufemi M, Trojanowski J, Bassett D, Lee V, Henderson M 2021 Science Advances Neuroscience Area Quantification HALO
Tau-tubulin kinase 1 phosphorylates TDP-43 at disease-relevant sites and exacerbates TDP-43 pathology Tian Y, Wang Y, Jablonski A, Hu Y, Sugam J, Koglin M, Stachel S, Zhou H, Uslaner J, Parmentier-Batteur S 2021 Neurobiology of Disease Neuroscience Area Quantification HALO
Pilot study of Tremelimumab with and without cryoablation in patients with metastatic renal cell carcinoma Campbell M, Matin S, Tam A, Sheth R, Ahrar K, Tidwell R, Rao P, Karam J, Wood C, Tannir N, Jonasch E, Gao J, Zurita A, Shah A, Jindal S, Duan F, Basu S, Chen H, Espejo A, Allison J, Yadav S, Sharma P 2021 Nature Communications Oncology Cytonuclear HALO
Cancer immune therapy with PD-1-dependent CD137 co-stimulation provides localized tumour killing without systemic toxicity Qiao Y, Qiu Y, Ding J, Luo N, Wang H, Ling X, Sun J, Wu Z, Wang Y, Liu Y, Guo F, Sun T, Shen W, Zhang M, Wu D, Chen B, Xu W, Wang X 2021 Nature Communications Immuno-oncology Cytonuclear, Multiplex IHC HALO
Small molecule inhibitors of ?-synuclein oligomers identified by targeting early dopamine-mediated motor impairment in†C. elegans Chen K, Menezes K, Rodgers J, )'Hara D, Tran N, Fujisawa K, Ishikura S, Khodaei S, Chau H, Cranston A, Kapadia M, Pawar G, Ping S, Krizus A, Lacoste A, Spangler S, Visanji N, Marras C, Majbour N, El-Agnaf O, Lozano A, Culotti, Suo S, Ryu W, Kalia S, Kalia L 2021 Molecular Neurodegeneration Neuroscience Cytonuclear HALO
Intratumoral Heterogeneity and Immune Response Indicators to Predict Overall Survival in a Retrospective Study of HER2-Borderline (IHC 2+) Breast Cancer Patients Radziuviene G, Rasmusson A, Augulis R, Grineviciute R, Zilenaite D, Laurinaviciene A, Ostapenko V, Laurinavicius A 2021 Frontiers in Oncology Immuno-oncology Membrane, Multiplex IHC HALO AI
The TRPA1 Channel Amplifies the Oxidative Stress Signal in Melanoma De Logu F, Monteiro de Araujo D, Ugolini F, Iannone L, Vannucchi M, Portelli F, Landini L, Titiz M, De Giorgi V, Geppetti P, Massi D, Nassini R 2021 Cells Area Quantification, Multiplex IHC HALO, HALO Link, HALO AI
CD98-induced CD147 signaling stabilizes the Foxp3 protein to maintain tissue homeostasis Geng J, Chen R, Yang F, Lin P, Zhu Y, Fu X, Wang K, Feng Z, Wu J, Zhang H, Li Q, Chen Z, Zhu P 2021 Cellular and Molecular Immunology Immuno-oncology Cytonuclear, Highplex FL HALO
Immune Response in Myocardial Injury:†In Situ†Hybridization and Immunohistochemistry Techniques for SARS-CoV-2 Detection in COVID-19 Autopsies Chong P, Iqbal J, Yeong J, Aw T, Chan K, Chui P 2021 Frontiers in Molecular Biosciences Infectious Disease HALO
STING regulates peripheral nerve regeneration and colony stimulating factor 1 receptor (CSF1R) processing in microglia Morozzi G, Rothen J, Toussaint G, De Lange K, Westritschnig K, Doelemeyer A, Ueberschlag V, Kahle P, Lambert C, Obrecht M, Beckmann N, Ritter V, Panesar M, Stauffer D, Garnier I, Mueller M, Guerini D, Keller C, Knehr J, Roma G, Bidinosti M, Brachat S, Morvan F, Forano M 2021 iScience Neuroscience Cytonuclear HALO AI
Deleting DNMT3A in CAR T cells prevents exhaustion and enhances antitumor activity Prinzing B, Zebley C, Petersen C, Fan Y, Anido A, Yi Z, Nguyen P, Houke H, Bell M, Haydar D, Brown C, Boi S, Alli S, Crawford J, Riberdy J, Park J, Zhou S, Velasquez M, DeRenzo C, Lazzarotto C, Tsai S, Vogel P, Pruett-Miller S, Langfitt D, Gottschalk S, Youngblood B, Krenciute G 2021 Science Translational Medicine Immuno-oncology Cytonuclear HALO
Isoform specific anti-TGF? therapy enhances antitumor efficacy in mouse models of cancer Gupta A, Budhu S, Fitzgerald K, Giese R, Michel A, Holland A, Campesato L, vanSnick J, Uyttenhove C, Ritter G, Wolchok J, Merghoub T 2021 Communications Biology Oncology Area Quantification HALO
Inhibitory effects and mechanisms of the anti-covid-19 traditional Chinese prescription, Keguan-1, on acute lung injury Bai, Z, Li P, Wen J, Han Y, Cui Y, Zhou Y, Shi Z, Chen S, Li Q, Zhao X, Wang Z, Li R, Guo Y, Zhan X, Xu G, Ding K, Wang J, Xiao X 2021 Journal of Ethnopharmacology Infectious Disease Highplex FL HALO
Soluble guanylate cyclase signalling mediates etoposide resistance in progressing small cell lung cancer Schenk M, Humprey S, Hossain A, Revill M, Pearsall S, Lallo A, Brown S, Bratt S, Galvin M, Descamps T, Zhou C, Pearce S, Priest L, Greenhalgh M, Chaturvedi A, Kerr A, Blackhall F, Dive C, Frese K 2021 Nature Communications Oncology Classifier, Area Quantification HALO
Spatial mapping of protein composition and tissue organization: a primer for multiplexed antibody-based imaging Hickey J, Neumann E, Radtke A, Camarillo J, Beuschel R, Albanese A McDonough E, Hatler J, Wiblin A, Fisher J, Croteau J, Small E, Sood A, Caprioli R, Angelo R. Nolan G, Chung K, Hewitt S, Germain R, Spraggins J, Lundberg E, Snyder M, Kelleher N, Saka S 2021 Nature Methods Review HALO
Alpha-synuclein from†patient Lewy bodies exhibits distinct pathological activity that†can be propagated in†vitro Marotta N, Ara J, Uemura N, Lougee M, Meymand E, Zhang B, Petersson E, Trojanowski J, Lee V 2021 Acta Neuropathologica Communications Neuroscience HALO
Advances in mass cytometry and its applicability to digital pathology in clinical-translational cancer research Cereceda K, Jorquera R, Villarroel-Espindola, F 2021 Advances in Laboratory Medicine Review HALO
Immuno-transcriptomic profiling of extracranial pediatric solid malignancies Brohl A, Sindiri S, Wei J, Milewski D, Chou H, Song Y, Wen X, Kumar J, Reardon H, Mudunuri U, Collins J, Nagaraj S, Gangalapudi V, Tyagi M, Zhu Y, Masih K, Yohe M, Shern J, Qi Y, Turpin B, Leino D, Iwata S, Andrulis I, Wunder J, Toledo S, Meltzer P, Lau C, Teicher B, Magnan H, Ladanyi M, Khan J 2021 Cell Reports Oncology HALO
*Immune cell topography predicts response to PD-1 blockade in cutaneous T cell lymphoma Phillips D, Matusiak M, Gutierrez BR, Bhate SS, Barlow GL, Jiang S, Demeter J, Smythe KS, Pierce RH, Fling SP, Ramchurren N, Cheever MA, Goltsev Y, West RB, Khodadoust MS, Kim YH, Sch¸rch CM, Nolan GP 2021 Nature Communications Immuno-oncology HALO
A single cell atlas reveals distinct immune landscapes in transplant and primary tumors that determine response or resistance to immunotherapy Wisdom AJ, Mowery YM, Hong CS, Qin X, Zhang D, Himes JE, Chen L, Fradin H, Muise ES, Xu ES, Carpenter DJ, Kent CL, Smythe KS, Williams N, Luo L, Ma Y, Owzar K, Bradley T, Kirsch DG 2020 Nature Communications Oncology, Immuno-oncology Cytonuclear HALO
Spatial Clustering of CD68+ Tumor Associated Macrophages with Tumor Cells is Associated
with Worse Overall Survival in Metastatic Clear Cell Renal Cell Carcinoma
Chakiryan NH, Kimmel GJ, Kim Y, Hajiran A, Aydin AM, Zemp L, Katende E, Nguyen J, Lopez-Blanco N, Chahoud J, Spiess PE, Fournier M, Dhillon J, Wang L, Moran-Segura C, El-Kenawi A, MulÈ J, Altrock PM, Manley BJ 2021 PLOS ONE Immuno-oncology Highplex FL HALO
A Deep Learning Approach for Tissue Spatial Quantification and Genomic Correlations of Histopathological Images Lu Z, Zhan X, Wu Y, Chng J, Shao W, Ni D, Han Z, Zhang J, Feng Q, Huang K 2020 Genomics, Proteomics & Bioinformatics Review HALO
CD117/c-kit Defines a Prostate CSC-Like Subpopulation Driving Progression and TKI Resistance Koran S. Harris, Shi L, Foster BM, Mobley ME, Elliott PL, Song CJ, Watabe K, Langefeld CD, Kerr BA 2020 Scientific Reports Oncology HALO
Localization of KRAS downstream target ARL4C to invasive pseudopods accelerates pancreatic cancer cell invasion Harada A, Matsumoto S, Yasumizu Y, Akama T, Eguchi H, Kikuchi A 2021 bioRxiv Oncology Area Quantification HALO
ABCF1 regulates dsDNA-induced immune responses in human airway epithelial cells Cao QT, Aguiar JA, Tremblay BJ-M, Abbas N, Tiessen N, Revill S, Makhdami N, Ayoub A, Cox G, Ask K, Doxey AC, Hirota JA 2020 Frontiers in Cellular and Infection Microbiology Immunology HALO
Accelerated phosphatidylcholine turnover in macrophages promotes adipose tissue inflammation in obesity Petkevicius K, Virtue S, Bidault G, Jenkins B, Cubuk C, Morgantini C, Aouadi M, Dopazo J, Serlie M, Koulman A, Vidal-Puig A 2019 Elife Classifier, Vacuole HALO
Bone Morphogenetic Protein Pathway Antagonism by Grem1 Regulates Epithelial Cell Fate in Intestinal Regeneration Koppens MAJ, Davis H, Valbuena GN, Mulholland EJ, Nasreddin N, Colombe M, Antanaviciute A, Biswas S, Friedrich M, Lee L, Oxford IBD cohort investigators, Wang LM, Koelzer VH, East JE, Simmons A, Winton DJ, Leedham SJ 2021 Gastroenterology Gastroenterology Area Quantification HALO
Effects of advanced age upon astrocyte-specific responses to acute traumatic brain injury in mice Early AN, Gorman AA, Van Eldik LJ, Bachstetter AD, Morganti JM 2019 Journal of Neuroinflammation Neuroscience Area Quantification HALO
FK506-binding protein 13 expression is upregulated in interstitial lung disease and correlated with clinical severity: a potentially protective role Tat V, Ayaub EA, Ayoub A, Vierhout M, Naiel S, Padwal MK, Abed S, Mekhael O, Tandon K, Revill SD, Yousof T, Bellaye PS, Kolb PS, Dvorkin-Gheva A, Naqvi A, Cutz JC , Hambly N, Kato J, Vaughan M, Moss J, Kolb MRJ, Ask K 2019 American Journal of Respiratory Cell and Molecular Biology Immunology, Fibrosis Area Quantification, Cytonuclear HALO
Integrated human pseudoislet system and microfluidic platform demonstrate differences in GPCR signaling in islet cells Walker JT, Haliyur R, Nelson HA, Ishahak M, Poffenberger G, Aramandla R, Reihsmann C, Luchsinger JR, Saunders DC, Wang P, Garcia-Ocana A, Bottino R, Agarwal A, Powers AC, Brissove M 2019 bioRxiv Gastroenterology Cytonuclear HALO
Detection of engineered T cells in FFPE tissue by multiplex in situ hybridization and immunohistochemistry Wright JH, Huang L-Y, Weaver S, Archila LD, McAfee MS, Hirayama AV, Chapuis AG, Bleakley M, Rongvaux A, Turtle CJ, Chanthaphavong S, Campbell JS, Pierce RH 2020 Journal of Immunological Methods Immunology ISH/FISH, ISH-IHC/FISH-IF HALO
Mesenchyme-derived IGF2 is a major paracrine regulator of pancreatic growth and function Hammerle CM, Sandovici I, Brierley GV, Smith NM, Zimmer WE, Zvetkova I, Prosser HM, Sekita Y, Lam BYH, Ma M, Cooper WN, Vidal-Puig A, Ozanne SE, Medina-Gomez G, Constancia M 2020 PLOS Genetics Toxicology Area Quantification HALO AI
Microbial regulation of enteric eosinophils and its impact on tissue remodeling and Th2 immunity Jimenez-Saiz R, Anipindi VC, Galipeau H, Ellenbogen Y, Chaudhary R, Koenig JF, Gordon ME, Walker TD, Mandur TS, Abed S, Humbles A, Chu DK, Ask K, Verdu EF, Jordana M 2019 Frontiers in Immunology Immunology, Infectious Disease Area Quantification HALO
Distinct fibroblast functional states drive clinical outcomes in ovarian cancer and are regulated by TCF21 Hussain A, Voisin V, Poon S, Dmytryshyn J ,Richman C, Meens J, Ho VW, Tang KH, Paterson J, Clarke B, Bernardini M, Bader G, Neel B, Ailles L 2019 Journal of Experimental Medicine Oncology Classifier, Area Quantification HALO
Transcriptomic analysis links diverse hypothalamic cell types to fibroblast growth factor 1-induced sustained diabetes remission Bentsen MA, Rausch DM, Mirzadeh Z, Muta K, Scarlett JM, Brown JM, Herranz-Perez V, Baquero AF, Thompson J, Alonge KM, Faber CL, Kaiyala KJ, Bennett C, Pyke C, Ratner C, Egerod KL, Holst B, Meek TH, Kutlu B, Zhang Y, Sparso T, Grove KL, Morton GJ, Kornum BR, Garcia-Verdugo J-M, Secher A, Jorgensen R, Schwartz MW, Pers TH 2020 Nature Communications Metabolism ISH/FISH HALO
PPAR-gamma induced AKT3 expression increases levels of mitochondrial biogenesis driving prostate cancer Galbraith L, Mui E, Nixon C, Hedley A, Strachan D, MacKay G, Sumpton D, Sansom O, Leung H, Ahmad I 2021 Oncogene Oncology ISH/FISH HALO
Pixelwise H-score: a novel digital image analysis-based metric to quantify membrane biomarker expression from immunohistochemistry images Ram S, Vizcarra P, Whalen P, Deng S, Painter C, Jackson-Fisher A, Pirie-Shepherd S, Xia X, Powell E 2021 PLOS One Other Cytonuclear, Multiplex IHC HALO
EHF is essential for epidermal and colonic epithelial homeostasis and suppresses Apc-initiated colonic tumorigenesis Reehorst C, Nightingale R, Luk I, Jenkins L, Koentgen F, Williams D, Darido C, Tan F, Anderton H, Chopin M, Schoffer K, Eissmann M, Buchert M, Mouradov D, Sieber O, Ernst M, Dhillon A, Maridason J 2021 Development Oncology Cytonuclear, Highplex FL HALO
LRPPRC regulates redox homeostasis via the circANKHD1/FOXM1 axis to enhance bladder urothelial carcinoma tumorigenesis Wei W, Wang N, Deng M, Dong P, Liu J, Xiang Z, Li X, Li Z, Liu Z, Peng Y, Li Z, Jiang L, Yao K, Ye Y, Lu W, Zhang Z, Zhou F, Liu Z, Xie D, Yu C 2021 Redox Biology Metabolism Cytonuclear, Multiplex IHC HALO
A growth factorñexpressing macrophage subpopulation orchestrates regenerative inflammation via GDF-15 Patsalos A, Halasz L, Medina-Serpas M, Berger W, Daniel B, Tzerpos P, Kiss M, Nagy G, Fischer C, Simandi Z, Varga T, Nagy L 2021 Journal of Experimental Medicine Muscle Fiber HALO
Antiretroviral therapy timing impacts latent tuberculosis infection reactivation in a tuberculosis/simian immunodeficiency virus coinfection model Sharan R, Ganatra S, Bucsan A, Cole J, Singh D, Alvarez X, Gough M, Alvarez C, Blakley A, Ferdin J, Thippeshappa R, Singh B, Escobedo R, Shivanna V, Dick E, Hall-Ursone S, Khader S, Mehra S, Rengarajan J, Kaushal D 2021 The Journal of Clinical Investigation Infectious Disease Cytonuclear, Highplex FL HALO
Effects of Dietary Pork Fat Cooked Using Different Methods on Glucose and Lipid Metabolism, Liver Inflammation and Gut Microbiota in Rats Zhu W, Xu Y, Liu J, Chen D, Zhang H, Yang Z, Zhou X 2021 Foods Metabolism Area Quantification HALO
Low immunogenicity of LNP allows repeated administrations of CRISPR-Cas9 mRNA into skeletal muscle in mice Kenjo E, Hozumi H, Makita Y, Iwabuchi K, Fujimoto N, Matsumoto S, Kimura M, Amano Y, Ifuku M, Naoe Y, Inukai N, Hotta A 2021 Nature Communications Other Muscle Fiber HALO
Comprehensive clinicopathologic study of alpha fetoprotein-expression in a large cohort of patients with hepatocellular carcinoma Ridder D, Weinmann A, Schindeldecker M, Urbansky L, Berndt K, Gerber T, Lang H, Lotz J, Lackner K, Roth W, Straub B 2021 International Journal of Cancer Oncology Cytonuclear, TMA HALO
Nuclear pore protein NUP210 depletion suppresses metastasis through heterochromatin-mediated disruption of tumor cell mechanical response Amin R, Shukla A, Zhu J, Kim S, Wang P, Tian S, Tran A, Paul D, Cappell S, Burkett S, Liu H, Lee M, Kruhlak M, Dwyer J, Simpson R, Hager G, Ruan Y, Hunter K 2021 Nature Communications Oncology Area Quantification HALO AI
Inter-organ transmission of hepatocellular senescence induces multi-organ dysfunction through the TGF? signalling pathway Kiourtis C, Terradas-Terradas M, Gee L, Hsieh Y, Nixon C, Clark W, Shaw R, Hanson P, Sumpton D, Mackay G, May S, Muller M, Najumudeen A, Campbell A, Barry S, Morris C, LeBeau F, Sansom O, Kirschner K, Oakley F, Bird T 2021 Research Square Other Area Quantification, Cytonuclear, Multiplex IHC HALO
Hedgehog-signalling in papillary fibroblasts is essential for hair follicle regeneration during wound healing Frech S, Forsthuber A, Korosec A, Lipp K, Kozumov V, Lichtenberger B 2021 Journal of Investigative Dermatology Dermatology Cytonuclear, Multiplex IHC HALO
Heterocellular OSM-OSMR signalling reprograms fibroblasts to promote pancreatic cancer growth and metastasis Lee B, Hogg E, Below C, Kononov A, Blanco-Gomez A, Heider F, Xu J, Hutton C, Zhang X, Scheidt T, Beattie K, Lamarca A, McNamara M, Valle J, Jorgensen C 2021 Nature Communications Oncology Classifier, Area Quantification HALO
Evaluation of Early Markers of Ischemia-reperfusion Injury and Preservation Solutions in a Modified Hindlimb Model of Vascularized Composite Allotransplantation Rostami S, Xu M, Datta S, Haykal S 2022 Transplantation Direct Cytonuclear, Multiplex IHC HALO
B7-1 and programmed cell death-ligand 1 in primary and lymph node metastasis lesions of non-small cell lung carcinoma Yamada T, Miki Y, Suzuki M, Kondoh O, Saito-Koyama R, Ono K, Okada Y, Sasano H 2021 Cancer Medicine Oncology Cytonuclear, Multiplex IHC HALO
A minimal standardized human bone marrow microphysiological system to assess resident cell behavior during normal and pathological processes Voeltzel T, Fossard G, Degaud M, Geistlich K, Gadot N, Jeanpierre S, Mikaelian I, Brevet M, Anginot A, Le Bousse-Kerdiles M, Trichet V, Lefort S, Maguer-Satta V 2021 Biomaterials Science Biomaterials Area Quantification, Cytonuclear HALO
Effect of Electroacupuncture at Siguan Acupoints on Expression of BDNF and TrkB Proteins in the Hippocampus of Post-Stroke Depression Rats Kang Z, Ye H, Chen T, et al. 2021 Journal of Molecular Neuroscience Neuroscience HALO
An ex vivo tumor fragment platform to dissect response to PD-1 blockade in cancer Voabil P, de Bruijn M, Roelofsen L, Hendriks S, Brokamp S, van den Braber M, Broeks A, Sanders J, Herzig P, Zippelius A, Blank C, Hartemink K, Monkhorst K, Haanen J, Schumacher T, Thommen D 2021 Nature Medicine Immuno-oncology Classifier, Multiplex IHC, HALO
Computational pathology reveals unique spatial patterns of immune response in H&E images from COVID-19 autopsies: preliminary findings Corredor G, Toro P, Bera K, Rasmussen D, Viswanathan V, Buzzy C, Fu P, Barton L, Stroberg E, Duval E, Gilmore H, Mukhopadhyay, Madabhushi A 2021 Journal of Medical Imaging Infectious Disease HALO Link
Anti-CD47 antibody administration via cisterna magna in proper dosage can reduce perihematomal cell death following intracerebral hemorrhage in rats Song Y, Wang H, Li F, Huang Q, Zhang Z 2021 Brain Research Bulletin Other Highplex FL HALO
Investigation of Breast Cancer Microstructure and Microvasculature from Time-Dependent DWI and CEST in Correlation with Histological Biomarkers Someya Y, Iima M, Imai H, Yoshizawa A, Kataoka M, Isoda H, Le Bihan D, Nakamoto Y 2021 Research Square Classifier, Multiplex IHC HALO
Secretory pathway Ca-ATPase2 (SPCA2) gene knockout results in mouse mammary gland changes and a secretory defect Reinhardt T, Lippolis J, Palmer M 2021 Research Square Other HALO
Specificity and off-target effects of AAV8-TBG viral vectors for the manipulation of hepatocellular gene expression in mice Kiourtis C, Wilczynska A, Nixon C, Clark W, May S, Bird T 2021 Biology Open Other Multiplex IHC HALO
Cross-Platform Comparison of Computer-assisted Image Analysis Quantification of In Situ mRNA Hybridization in Investigative Pathology Holzer TR, Hanson JC, Wray EM, Bailey JA, Kennedy KR, Finnegan PR, Nasir A, Credille KM 2019 Applied Immunohistochemistry & Molecular Morpholgy Other ISH/FISH HALO
spatialTIME and iTIME: R package and Shiny application for visualization and analysis of immunofluorescence data Creed J, Wilson C, Soupir A, Colin-Leitzinger C, Kimmel G, Ospina O, Chakiryan N, Markowitz J, Peres L, Coghill A, Fridley B 2021 Bioinformatics Other Classifier, Cytonuclear, Highplex FL HALO
Local radiotherapy and E7 RNA-LPX vaccination show enhanced therapeutic efficacy in preclinical models of HPV16+†cancer Salomon N, Selmi A, Grunwitz C, Kong A, Stanganello E, Neumaier J, Petschenka J, Diken M, Kreiter S, Tureci O, Sahin U, Vascotto F 2021 Cancer Immunology, Immunotherapy Oncology, Infectious Disease Highplex FL HALO
Clinically relevant mitochondrial-targeted therapy improves chronic outcomes after traumatic brain injury Hubbard W, Spry M, Gooch J, Cloud A, Vekaria H, Burden S, Powell D, Berkowitz B, Geldenhuys W, Harris N, Sullivan P 2021 Brain Neuroscience Area Quantification HALO
Anti-CAIX BB? CAR4/8 T Cells Exhibit Superior Efficacy in a Clear Cell Renal Cell Carcinoma (ccRCC) Mouse Model Wang Y, Buck A, Grimaud M, Culhane A, Kodangattil S, Razimbaud C, Bonal D, Nguyen Q, Zhu Z, Wei K, O'Donnell M, Huang Y, Signoretti S, Choueiri T, Freeman G, Zhu Q, Marasco 2021 Molecular Therapy: Oncolytics Oncology Cytonuclear, Multiplex IHC HALO
The microglial P2Y6†receptor mediates neuronal loss and memory deficits in neurodegeneration Puigdellivol M, Milde S, Vilalta A, Cockram T, Allendorf D, Lee J, Dundee J, Pampuscenko K, Borutaite V, Nuthall H, Brelstaff J, Spillantini G, Brown G 2021 Cell Reports Neuroscience Area Quantification, Cytonuclear, Multiplex IHC HALO
Cannabinoid control of gingival immune activation in chronically SIV-infected rhesus macaques involves modulation of the indoleamine-2,3-dioxygenase-1 pathway and salivary microbiome McDew-White M, Lee E, Alvarez X, Sestak K, Ling B, Byrareddy S, Okeoma C, Mohan M 2022 EBioMedicine Infectious Disease Area Quantification, Cytonuclear, Highplex FL HALO
Neoadjuvant immunotherapy with nivolumab and ipilimumab induces major pathological responses in patients with head and neck squamous cell carcinoma Vos J, Elbers J, Krijgsman O, Traets J, Qiao X, van der Leun A, Lubeck Y, Seignette I, Smit L, Willems S, van den Brekel M, Dirven R, Karakullukcu B, Karssemakers L, Klop W, Lohuis P, Schreuder W, Smeele L, van der Velden L, Tan I, Onderwater S, Jasperse B, Vogel W, Al-Mamgani A, Keijser A, van der Noort V, Broeks A, Hooijberg E, Peeper D, Schumacher T, Blank C, de Boer J, Haanen J, Zuur C 2021 Nature Communications Oncology Classifier, Highplex FL HALO
ACE2-IgG1 fusions with improved in vitro and in vivo activity against SARS-CoV-2 Iwanaga N, Cooper L, Rong L, Maness N, Beddingfield B, Qin Z, Crabtree J, Tripp R, Yang H, Blair R, Jangra S, Garcia-Sastre A, Schotsaert M, Chandra S, Robinson J, Srivastava A, Rabito F, Qin X, Kolls J 2022 iScience Infectious Disease Highplex FL HALO AI
Tumor MHC Class I Expression Associates with Intralesional Interleukin-2 Response in Melanoma Pourmaleki M, Jones C, Ariyan C, Zeng Z, Pirun M, Navarrete D, Li Y, Zhang M, Nandakumar S, Campos C, Nadeem S, Klimstra D, Temple-Oberle C, Brenn T, Kipson E, Schenk K, Stein J, Taube J, White M, Traweek R, Wargo J, Kirkwood J, Gasmi B, Goff S, Corwin A, McDonough E, Ginty F, Callahan M, Schietinger A, Socci N, Mellinghoff I, Hollmann T 2022 Cancer Research Immunology Immuno-oncology Highplex FL HALO
Progranulin mediates immune evasion of pancreatic ductal adenocarcinoma through regulation of MHCI expression Cheung P, Yang J, Fang R, Borgers A, Krengel K, Stoffel A, Althoff K, Yip C, Siu E, Ng L, Lang K, Cham L, Engel D, Soun C, Cima I, Scheffler B, Striefler J, Sinn M, Bahra M, Pelzer U, Oettle H, Markus P, Smeets E, Aarntzen E, Savvatakis K, Liffers S, Lueong S, Neander C, Bazarna A, Zhang X, Paschen A, Crawford H, Chan A, Cheung S, Siveke J 2022 Nature Communications Oncology Cytonuclear, Spatial Analysis, Highplex FL HALO
Tumor cell-derived exosomes deliver TIE2 protein to macrophages to promote angiogenesis in cervical cancer Du S, Qian J, Tan S, Li W, Liu P, Zhao J, Zeng Y, Xu L, Wang Z, Cai J 2022 Cancer Letters Oncology Area Quantification, Cytonuclear, Spatial Analysis, Highplex FL HALO
Understanding the impact of chemotherapy on the immune landscape of high-grade serous ovarian cancer Vanguri R, Benhamida J, Young J, Li Y, Zivanovic O, Chi D, Snyder A, Hollmann T, Mager K 2022 Gynecologic Oncology Reports Oncology Classifier, Cytonuclear, Highplex FL HALO
Landscape of cancer-associated fibroblasts identifies the secreted biglycan as a protumor and immunosuppressive factor in triple-negative breast cancer Zheng S, Zou Y, Tang Y, Yang A, Liang J, Wu L, Tian W, Xiao W, Xie X, Yang L, Xie J, Wei W, Xie X 2022 OncoImmunology Immuno-oncology Cytonuclear, Multiplex IHC HALO
The Tumor Immune Landscape and Architecture of Tertiary Lymphoid Structures in Urothelial Cancer van Dijk N, Gil-Himenez A, Silina K, van Montfoort M, Einerhand S, Jonkman L, Voskuilen C, Peters D, Sanders J, Lubeck Y, Broeks A, Hooijberg E, Vis D, van den Broek M, Wessels L, van Rhijn B, van der Heijden M 2021 Frontiers in Immunology Immuno-oncology Cytonuclear, Spatial Analysis, Highplex FL HALO AI
Postmortem high-dimensional immune profiling of severe COVID-19 patients reveals distinct patterns of immunosuppression and immunoactivation Wu H, He P, Ren Y, Xiao S, Wang W, Liu Z, Li H, Wang Z, Zhang D, Cai J, Zhou X, Jiang D, Fei X, Zhao L, Zhang H, Liu Z, Chen R, Li W, Wang C, Zhang S, Qin J, Nasan B, Sun C 2022 Nature Communications Infectious Disease Multiplex IHC HALO
EBV+†tumors exploit tumor cell-intrinsic and -extrinsic mechanisms to produce regulatory T cell-recruiting chemokines CCL17 and CCL22 Jorapur A, Marshall L, Jacobson S, Xu M, Marubayashi S, Zibinsky M, Hu D, Robles O, Jackson J, Baloche V, Busson P, Wustrow D, Brockstedt D, Talay O, Kassner P, Cutler G 2022 PLOS Pathogens Oncology ISH/FISH HALO
AAV9/MFSD8 gene therapy is effective in preclinical models of neuronal ceroid lipofuscinosis type 7 disease Chen X, Dong T, Hu Y, Shaffo F, Belur N, Mazzulli J, Gray S 2022 The Journal of Clinical Investigation Neuroscience Area Quantification, ISH/FISH HALO
Transcription factor Mesenchyme Homeobox Protein 2 (MEOX2) modulates nociceptor function Kokotovic T, Lenartowicz E, Langeslag M, Ciotu C, Fell C, Scaramuzza A, Fischer M, Kress M, Penninger J, Nagy V 2022 The FEBS Journal Neruoscience Multiplex IHC HALO
Collaborative workflow between pathologists and deep learning for evaluation of tumor cellularity in lung adenocarcinoma Sakamoto T, Furukawa T, Pham H, Kuroda K, Tabata K, Kshima Y, Okoshi E, Morimoti S, Bychkov A, Fukuoka J 2022 bioRxiv Oncology Cytonuclear, Multiplex IHC HALO AI
Switching to Regular Diet Partially Resolves Liver Fibrosis Induced by High-Fat, High-Cholesterol Diet in Mice Farooq M, Hameed H, Dimanchi-Boitrel M, Piquet-Pellorce C, Samson M, Le Seyec J 2022 Nutrients Metabolism Area Quantification HALO
T cell-mediated anti-tumor immunity cooperatively induced by TGF?R1 antagonism and gemcitabine counteracts reformation of the stromal barrier in pancreatic cancer Li D, Schaub N, Guerin T, Bapiro T, Richards F, Chen V, Talsania K, Kumar P, Gilbert D, Scholmer J, Kim S, Sorber R, Teper Y, Bautista W, Palena C, Ock C, Jodrell D, Pate N, Mehta M, Zhao Y, Kozlov S, Rudloff U 2021 Molecular Cancer Therapeutics Immuno-oncology Highplex FL HALO
Genome Sequence and Experimental Infection of Calves with Bovine Gammaherpesvirus 4 (BoHV-4) Bauermann F, Falkenberg S, Martins M, Dassanayake R, Neill J, Ridpath J, Silveira S, Palmer M, Buysse A, Mohr A, Flores E, Diel D 2022 Research Square Infectious Disease, Other ISH/FISH HALO
New Fully Automated Preparation of High Apparent Molar Activity 68Ga-FAPI-46 on a Trasis AiO Platform Da Pieve C, Braga M, Turton D, Valla F, Cakmak P, Plate K, Kramer-Marek G 2022 Molecules Other Cytonuclear, Highplex FL HALO
Retrospective analysis of the efficacy of adjuvant cytokine-induced killer cell immunotherapy combined with chemotherapy in colorectal cancer patients after surgery Li X, Zhou H, Huang W, Wang X, Meng M, Hou Z, Liao L, Tang W, Xie Y, Wang R, Yu H, Wang L, Zhu H, Wang W, Tan J, Li R 2022 Clinical & Translational Immunology Oncology Cytonuclear, Highplex FL HALO
Fasting improves therapeutic response in hepatocellular carcinoma through p53-dependent metabolic synergism Krstic J, Reinisch I, Schindlmaier K, Galhuber M, Riahi Z, Berger N, Kupper N, Moyschewitz E, Auer M, Michenthaler H, Nossing C, Repaoli M, Ramadani-Muja J, Usluer S, Stryeck S, Pichler M, Rinner B, Deutsch A, Reinisch A, Madl T, Chiozzi R, Heck A, Huch M, Malli R, Prokesch 2022 Science Advances Oncology Classifier HALO
GPNMB expression identifies TSC1/2/mTOR-associated and MiT family translocation-driven renal neoplasms Salles D, Asrani K, Woo J, Vidotto T, Liu H, Vidal I, Matoso A, Netto G, Argani P, Lotan T 2022 The Journal of Pathology Oncology Membrane HALO
High-dose rifampin improves bactericidal activity without increased intracerebral inflammation in animal models of tuberculous meningitis Ruiz-Bedoya C, Mota F, Tucker E, Mahmud F, Reyes-Mantilla M, Erice C, Bahr M, Flavahan K, De Jesus P, Kim J, Foss C, Peloquin C, Hammound D, Ordonez A, Pardo C, Jain S 2022 The Journal of Clinical Investigation Infectious Disease Area Quantification HALO
Evaluation of a PEGylated Fibroblast Growth Factor 21 Variant Using Novel Preclinical Magnetic Resonance Imaging and Magnetic Resonance Elastography in a Mouse Model of Nonalcoholic Steatohepatitis Tang H, Li J, Zinker B, Boehm S, Mauer A, Rex-Rabe S, Glaser K, Fronheiser M, Bradstreet T, Nakao Y, Petrone T, Pena A, Villano M, Chow P, Malhi H, Charles E, Hayes W, Ehman R, Du S, Yin M 2022 Journal of Magnetic Resonance Imaging Metabolism Vacuole HALO
Therapeutic treatment with the anti-inflammatory drug candidate MW151 may partially reduce memory impairment and normalizes hippocampal metabolic markers in a mouse model of comorbid amyloid and vascular pathology Braun D, Powell D, McLouth C, Roy S, Watterson D, Van Eldik 2022 PLOS One Neruoscience Classifier, Area Quantification HALO
African-Ancestry Associated Gene Expression Signatures and Pathways in Triple Negative Breast Cancer, a Comparison across Women of African Descent Martini R, Delpe P, Chu T, Arora K, Lord B, Verma A, Chen Y, Gebregzabher, Oppong J, Adjei E, Jibril A, Awuah B, Bekele M, Abebe E, Kyei I, Aitpillah F, Adinku M, Ankomah K, Osei-Bonsu E, Chitale D, Bensenhaver J, Nathanson S, Jackson L, Jiagge E, Petersen L, Proctor E, Gyan K, Gibbs L, Monojlovic Z, Kittles R, White J, Yates C, Manne U, Gardner K, Mongan N, Cheng E, Ginter P, Hoda S, Elemento O, Robine N, Sboner A, Carpten J, Newman L, Davis M 2022 medRxiv Oncology Multiplex IHC, Serial Section HALO
A selective and orally bioavailable VHL-recruiting PROTAC achieves SMARCA2 degradation in vivo Kofink C, Trainor N, Mair B, Wrhrle S, Wurm M, Mischerikow N, Bader G, Rumpel K, Gerstberger T, Cui Y, Greb P, Garavel G, Scharnweber M, Fuchs J, Gremel G, Chette P, Hopf S, Budano N, Rinnenthal J, Gmaschitz G, Diers E, McLennan R, Roy M, Whitworth C, Vetma V, Mayer M, Koegl M, Ciulli A, Weinstabl H, Farnaby W 2022 Biological and Medicinal Chemistry Classifier, Cytonuclear, Multiplex IHC HALO
Obesity due to Steroid Receptor Coactivator-1 deficiency is associated with endocrine and metabolic abnormalities Cacciottolo T, Henning E, Keogh J, Lassen P, Lawler K, Bounds R, Ahmed R, Perdikari A, Mendes de Oliverira E, Smith M, Godfrey E, Johnson E, Hodson L, Clement K, van der Klaauw A, Farooqi I 2022 The Journal of Clinical Endocrinology & Metabolism Metabolism Vacuole HALO
Intratumoural spatial distribution of S100B?+?folliculostellate cells is associated with proliferation and expression of FSH and ER? in gonadotroph tumours Ilie M, Vasiljevic A, Chanal M, Gadot N, Chinezu L, Jouanneau E, Hennino A, Raverot G, Bertolino P 2022 Acta Neuropathologica Communications Oncology Cytonuclear, Spatial Analysis HALO
High-Field Asymmetric Waveform Ion Mobility Spectrometry and Parallel Reaction Monitoring Increases Sensitivity for Clinical Biomarker Quantitation from FormalinFixed, Paraffin-Embedded Tumor Biopsies Sweet S, Chain D, Yu W, Martin P, Rebelatto M, Chambers A, Cecchi F, Kim Y 2022 bioRxiv Other HALO AI
Glioblastoma exosomes influence glial cell hyaluronic acid deposition to promote invasiveness Koessinger D, Novo D, Koessinger A, Zerbst D, Moore M, Mitchell L, Neilson M, Stevenson K, Chalmers A, Birch J, Norman J 2022 bioRxiv Cytonuclear HALO
The oral drug nitazoxanide restricts SARS-CoV-2 infection and attenuates disease pathogenesis in Syrian hamsters Miorin L, Mire C, Ranjbar S, Hume A, Huang J, Crossland N, White K, Laporte M, Kehrer T, Haridas V, Moreno E, Nambu A, Jangra S, Cupic A, Dejosez M, Abo K, Tseng A, Werder R, Rathnasinghe R, Mutetwa T, Ramos I, Sainz de Aja J, Garcia de Alba Rivas C, Schotsaert M, Corley R, Falvo J, Fernandez-Sesma A, Kim C, Rossingnol J, Wilson A, Zwaka T, Kotton D, Muhlberger E, Garcia-Sastre A, Goldfeld A 2022 bioRxiv Infectious Disease Area Quantification HALO
Pathogenesis of follicular thymic hyperplasia associated with rheumatoid arthritis Ohe R, Yang S, Yamashita D, Ichikawa C, Saito A, Kabasawa T, Utsunomiya A, Aung N, Urano Y, Kitaoka T, Suzuki K, Takahara D, Sasaki A, Takakubo Y, Takagi M, Yamakawa M, Futakuchi M 2022 Pathology International Other Cytonuclear, Multiplex IHC HALO
Pancreas resident macrophage-induced fibrosis has divergent roles in pancreas inflammatory injury and PDAC Baer J, Zuo C, Kang L, Alarcon de la Lastra A, Bocherding N, Knolhoff B, Bogner S, Zhu Y, Lewis M, Zhang N, Kim K, Fields R, Mills J, Ding L, Randolph G, DeNardo D 2022 bioRxiv Fibrosis Classifier, Area Quantification, Cytonuclear, Multiplex IHC, Highplex FL, Figure Maker HALO
Nuclear expression of pSTAT3Tyr705†and pSTAT3Ser727†in the stromal compartment of localized hormone-naÔve prostate cancer Marginean F, Hellsten R, Krzyanowska A, Bjartell A 2022 Pathology - Research and Practice Oncology Cytonuclear, Multiplex IHC, TMA HALO
Extracellular vesicles released after cranial radiation: An insight into an early mechanism of brain injury Sukati S, Ho J, Chaiswing L, Sompol P, Pandit H, Wei W, Izumi T, Chen Q, Weiss H, Noel T, Bondada S, Butterfield D, St. Cair D 2022 Brain Research Neuroscience Area Quantification HALO
An Fc-inert PD-L1◊4-1BB bispecific antibody mediates potent anti-tumor immunity in mice by combining checkpoint inhibition and conditional 4-1BB co-stimulation Muik A, Altintas I, Gieseke F, Schoedel K, Burm S, Toker A, Salcedo T, Verzijl, Eisel D, Grunwitz C, Kranz L, Vormehr M, Satijn D, Diken M, Kreiter S, Sasser K, Ahmadi T, Tureci O, Breij E, Jure-Kunkel M, Sahin U 2022 OncoImmunology Immuno-oncology Area Quantification, Immune, Multiplex IHC HALO
Eradicating tumor in a recurrent cervical cancer patient with autologous tumorinfiltrating lymphocytes and a modified lymphodepleting regimen Guo J, Luo N, Ai G, Yang W, Zhu J, Li C, Chen R, Zhang C, Liu S, Jin H, Cheng Z 2022 Journal for ImmunoTherapy of Cancer Immuno-oncology
e The Association of Cholesterol Uptake and Synthesis with Histology and Genotype in Cortisol-Producing Adenoma (CPA) Motomura N, Yamazaki Y, Koga D, Harashima S, Gao X, Tezuka Y, Omata K, Ono Y, Morimoto R, Satoh F, Nakamura Y, Kwon G, Choi M, Ito A, Sasano H 2022 International Journal of Molecular Sciences Area Quantification, Cytonuclear, Membrane HALO
IgA-dominated humoral immune responses govern patients' outcome in endometrial cancer Mandal G, Biswas S, Anadon C, Yu X, Gatenbee C, Prabhakaran S, Payne K, Chaurio R, Martin A, Innamarato P, Moran C, Powers J, Harro C, Mine J, Sprenger K, Rigolizzo K, Wang X, Curiel T, Rodriguez P, Anderson A, Saglam O, Conejo-Garcia J 2021 Cancer Research Immuno-oncology Classifier, Cytonuclear, Highplex FL HALO
Tertiary lymphoid structures critical for prognosis in endometrial cancer patients - a TransPORTEC study Horeweg N, Workel, H, Loiero D, Church D, Vermij L, LÈon-Castillo A, Krog R, de Boer S, Nout R, Powel M, Mileshkin L, MacKay H, Leary A, Singh N, J¸rgenliemk-Schulz I, Creutzberg C, Koelzer V, Nijman H, Bosse T, Bruyn M 2022 Nature Communications Oncology Cytonuclear, Multiplex IHC, TMA HALO, HALO AI
Genomic and single-cell landscape reveals novel drivers and therapeutic vulnerabilities of transformed cutaneous T-cell lymphoma Song X, Chang S, Seminario-Vidal L, de Mingo Pulido A, Tordesillas L, Song X, Reed R, Harkins A, Whiddon S, Nguyen J, Segura C, Zhang C, Yoder S, Sayegh Z, Zhao Y, Messina J, Harro C, Zhang X, Conejo-Garcia J, Berglund A, Sokol L, Zhang J, Rodriguez P, Mule J, Futreal A, Tsai K, Chen P 2022 Cancer Discovery Oncology Cytonuclear, Highplex FL, TMA HALO
Collagen-VI expression is negatively mechanosensitive in pancreatic cancer cells and supports the metastatic niche Papalazarou V, Drew J, Juin A, Spence H, Nixon C, Salmeron-Sanchez M, Machesky L 2022 bioRxiv Oncology Area Quantification, Figure Maker HALO
An immunoPET probe to SARS-CoV-2 reveals early infection of the male genital tract in rhesus macaques Madden P, Thomas Y, Blair R, Samer S, Doyle M, Midkiff C, Becker M, Arif M, McRaven M, Simons L, Carias A, Martinelli E, Lorenzo-Redondo R, Hultquist J, Villinger F, Veazey R, Hope T 2022 bioRxiv Infectious Disease HALO
Transcriptional and DNA Methylation Signatures of Subcutaneous Adipose Tissue and Adipose-Derived Stem Cells in PCOS Women Divoux A, Erdos E, Whytock K, Osborne T, Smith S 2022 Cells Area Quantification HALO
Tumor immune cell clustering and its association with survival in African American women with ovarian cancer Wilson C, Soupir A, Thapa R, Creed J, Nguyen J, Segura C, Gerke T, Schildkraut J, Peres L, Fridley B 2022 PLOS Computational Biology Cytonuclear, Highplex FL HALO
Inhibition of†CK2 mitigates Alzheimerís tau pathology by†preventing NR2B synaptic mislocalization Marshall C, McBride J, Changolkar L, Riddle D, Trojanowski J, Lee V M-Y 2022 Acta Neuropathologica Communications Area Quantification HALO
Immunologic Gene Signature Analysis Correlates Myeloid Cells and M2 Macrophages with Time to Trabectedin Failure in Sarcoma Patients Schroder B, Zhang Y, Smythe K, Desai P, Thomas A, Viveiros P, Alexiev B, Obeidin F, Chen E, Cranmer L, Wagner M, Jones R, Campbell J, Pierce R, He Q, Pollack S 2022 Cancers Oncology Cytonuclear, Highplex FL HALO
Fatal Neurodissemination and SARS-CoV-2 Tropism in K18-hACE2 Mice Is Only Partially Dependent on hACE2 Expression Carossino M, Kenney D, O'Connell A, Montarnaro P, Tseng A, Gertje H, Grosz K, Ericsson M, Huber B, Kurnick S, Subramaniam S, Kirkland T, Walker J, Francis K, Klose A, Paragas N, Bosmann M, Saeed M, Balasuriya U, Douam F, Crossland N 2022 Viruses Infectious Disease Classifier, Area Quantification, Highplex FL HALO
Multi-modal molecular imaging maps the correlation between tumor microenvironments and nanomedicine distribution Strittmatter N, Moss J, Race A, Sutton D, Canales J, Ling S, Wong E, Wilson J, Smith A, Howes C, Bunch J, Barry S, Goodwin R, Ashford M 2022 Theranostics Immuno-oncology Highplex FL HALO, HALO AI
An anti-PD-1ñGITR-L bispecific agonist induces GITR clustering-mediated T cell activation for cancer immunotherapy Chan S, Belmar N, Ho S, Rogers B, Stickler M, Graham M, Lee E, Tran N, Zhang D, Gupta P, Sho M, MacDonough T, Woolley A, Kim H, Zhang H, Liu W, Zheng P, Dezso Z, Halliwill K, Ceccarelli M, Rhodes S, Thakur A, Forsyth C, Xiong M, Tan S, Iyer R, Lake M, Digiammarino E, Zhou L, Bigelow L, Longenecker K, Judge R, Liu C, Trumble M, Remis J, Fox M, Cairns B, Akamatsu Y, Hollenbaugh D, Farding F, Alvarez H 2022 Nature Cancer Immuno-oncology Area Quantification, Cytonuclear, Highplex FL HALO
ZEB1 transcription factor promotes immune escape in melanoma Plaschka M, Benboubker V, Grimont M, Berthet J, Tonon L, Lopez J, Le-Bouar M, Balme B, Tondeau G, de la Fouchardiere A, Larue L, Puisieux A, Grinberg-Bleyer Y, Bendriss-Vermare N, Dubois B, Caux C, Dalle S, Caramel J 2022 Journal for ImmunoTherapy of Cancer Immuno-oncology Cytonuclear, Multiplex IHC, Highplex FL HALO
Malfunction of airway basal stem cells plays a crucial role in pathophysiology of tracheobronchopathia osteoplastica Hong Y, Shan S, Gu Y, Huang H, Zhang Q, Han Y, Dong Y, Liu Z, Huang M, Ren T 2022 Nature Communications Other Cytonuclear, Multiplex IHC HALO
Deep-Learning-Aided Detection of Mycobacteria in Pathology Specimens Increases the Sensitivity in Early Diagnosis of Pulmonary Tuberculosis Compared with Bacteriology Tests Zaizen Y, Kanhori Y, Ishijima S, Kitamura Y, Yoon H, Ozasa M, Mukae H, Bychkov A, Hoshino T, Fukuoka J 2022 Diagnostics Infectious Disease HALO, HALO AI
Acetyl-CoA-carboxylase 1 (ACC1) plays a critical role in glucagon secretion Veprik A, Denwood G, Liu D, Bakar R, Morfin V, McHugh K, Tebeka N, Vetterli L, Yonova-Doing E, Gribble F, Reimann F, Hoehn K, Hemsley P, Ahnfelt-Ronne J, Rorsman P, Zhang Q, Wet H, Cantley J 2022 Communications Biology Metabolism Cytonuclear, Highplex FL HALO
Sulforaphane exhibits antiviral activity against pandemic SARS-CoV-2 and seasonal HCoV-OC43 coronaviruses in vitro and in mice Ordonez A, Bullen C, Villabona-Rueda A, Thompson E, Turner M, Merino V, Yan Y, Kim J, Davis S, Komm O, Powell J, D'Alessio F, Yolken R, Jain S, Jones-Brando L 2022 Communications Biology Infectious Disease Area Quantification, Multiplex IHC HALO
Extracellular matrix proteins regulate NK cell function in peripheral tissues Bunting M, Vyas M, Requesens M, Langenbucher A, Schiferle E, Manguso R, Lawrence M, Demehri S 2022 Science Advances Dermatology Cytonuclear, Highplex FL HALO
Multiplex Immunohistochemical Phenotyping of T Cells in Primary Prostate Cancer Ozbek B, Ertunc O, Erickson A, Vidal I, Gomes-Alexandre C, Guner G, Hicks J, Jones T, Taube J, Sfanos K, Yegnasubramanian S, DeMarzo A 2022 The Prostate Immuno-oncology Classifier, Cytonuclear, Highplex FL, Serial Section, Registration, Figure Maker, TMA HALO
Interspatial Distribution of Tumor and Immune Cells in Correlation with PD-L1 in Molecular Subtypes of Gastric Cancers Dislich B, Mertz K, Gloor B, Langer R 2022 Cancers Immuno-oncology Multiplex IHC, Spatial Analysis, Figure Maker HALO
Adrenal tropism of SARS-CoV-2 and adrenal findings in a post-mortem case series of patients with severe fatal COVID-19 Paul T, Ledderose S, Bartsch H, Sun N, Soliman S, Markl B, Ruf V, Herms J, Stern M, Keppler O, Delbridge C, Muller S, Piontek G, Kimoto Y, Schreiber F, Williams T, Neumann J, Knosel T, Schulz H, Spallek R, Graw M, Kirchner T, Walch A, Rudelius M 2022 Nature Communications Infectious Disease Cytonuclear, Highplex FL HALO
Soluble TREM2 induces microglia dysfunction and brain damage while cleavage-reduced TREM2 shows sustained microglia activation with enhanced remyelination in the cuprizone model Beckmann N, Neuhaus A, Zurbruegg S, Joller S, Feuerbach D, Doelemeyer A, Schweizer T, Rudin S, Nuemann U, Berth R, Frieauff W, Gasparani F, Shimshek D 2022 Research Square Neuroscience HALO
Genome-wide mapping of oncogenic pathways and genetic modifiers of chemotherapy using a high-risk hepatoblastoma genetic model Fang J, Singh S, Natarajan S, Tillman H, Abuzaid A, Durbin A, Lee H, Wu Q, Steele J, Connelly J, Cheng C, Jin H, Chen W, Fan Y, Pruett-Miller S, Rehg J, Emmons J, Cairo S, Wang R, Glazer E, Murphy A, Chen T, Davidoff A, Easton J, Chen X, Yang J 2022 Research Square Oncology Classifier HALO
Spatially mapping the immune landscape of melanoma using imaging mass cytometry Moldoveanu D, Ramsay L, Lajoie M, Anderson-Trocme L, Lingrand M, Berry D, Perus L, Wei Y, Moraes C, Alkallas R, Rajkumar S, Zuo D, Dankner M, Xu E, Bertos N, Najafabadi H, Gravel S, Costantino S, Richer M, Lund A, Del Rincon S, Spatz A, Miller W, Jamal R, Lapointe R, Mes-Masson A, Turcotte S, Petrecca K, Dumitra S, Meguerditchian A, Richardson K, Tremblay F, Wang B, Chergui M, Guiot M, Watters K, Stagg J, Quail D, Mihalcioiu C, Meterissian S, Watson I 2022 Science Immunology Oncology Highplex FL HALO
Improved cognitive impairments by silencing DMP1 via enhancing the proliferation of neural progenitor cell in Alzheimer-like mice Zhao H, Wei J, Du Y, Chen P, Liu X, Liu H 2022 Aging Cell Neuroscience Cytonuclear, Highplex FL HALO
A tumor suppressor role for EZH2 in diffuse midline glioma pathogenesis Dhar S, Gadd S, Patel P, Vaynshteyn Jm Raju G, Hashizume R, Brat D, Becher O 2022 Acta Neuropathologica Communications Neuroscience HALO
Loss of ubiquitin-specific peptidase 18 destabilizes 14-3-3? protein and represses lung cancer metastasis Chen Z, Zheng L, Chen Y, Liu X, Kawakami M, Mustachi L, Roszik J, Ferry-Galow K, Parchment R, Liu X, Andresson T, Duncan G, Kurie J, Rodriguez-Canales J, Liu X, Dmitrovsky E 2022 Cancer Biology & Therapy Oncology Classifier, Cytonuclear HALO
Ad26.COV2.S prevents upregulation of SARS-CoV-2 induced pathways of inflammation and thrombosis in hamsters and rhesus macaques Aid M, Vidal S, Piedra-Mora C, Ducat S, Chan C, Bondoc S, Colarusso A, Starke C, Nekorchuk M, Busman-Sahay K, Estes J, Martinot A, Barouch D 2022 PLOS Pathogens Infectious Disease Area Quantification, Multiplex IHC HALO, HALO AI
Clinical tissue biomarker digital image analysis: A review of current applications Li Z, Bui M, Pantanowitz L 2022 Human Pathology Reports Review HALO
Peritumoral TIGIT+CD20+†B cell infiltration indicates poor prognosis but favorable adjuvant chemotherapeutic response in gastric cancer Liu H, Wu J, Xu X, Wang H, Zhang C, Yin S, He Y 2022 International Immunopharmacology Oncology Cytonuclear, Spatial Analysis, Highplex FL HALO
Subpopulations of cancer-associated fibroblasts link the prognosis and metabolic features of pancreatic ductal adenocarcinoma Hu B, Wu C, Mao H, Gu H, Dong H, Yan J, Qi Z, Yuan L, Dong Q, Long J 2022 Annals of Translational Medicine Oncology Cytonuclear, Highplex FL HALO
Vertical transmission of attaching and invasive E. coli from the dam to neonatal mice predisposes to more severe colitis following exposure to a colitic insult later in life Brand M, Proctor A, Hostetter J, Zhou N, Friedberg I, Jergens A, Phillips G, Wannemuehler M 2022 PLOS ONE Other ISH/FISH HALO
Advanced Age and Neurotrauma Diminish Glutathione and Impair Antioxidant Defense after Spinal Cord Injury Stewart A, Glaser E, Mott C, Bailey W, Sullivan P, Patel S, Gensel J 2022 Journal of Neurotrauma Neuroscience Axon HALO
Humanized mice reveal a macrophage-enriched gene signature defining human lung tissue protection during SARS-CoV-2 infection Kenney D, O'Connell A, Turcinovic J, Montanaro P, Hekman R, Tamura T, Berneshawi A, Cafiero T, Abdullatif S, Blum B, Goldstein S, Heller B, Gertje H, Bullitt E, Trachtenberg A, Chavez E, Nono E, Morrison C, Tseng A, Sheikh A, Kurnick S, Grosz K, Bosmann M, Ericsson M, Huber B, Saeed M, Balazs A, Francis K, Klose A, Paragas N, Campbell J, Connor J, Emili A, Crossland N, Ploss A, Douam F 2022 Cell Reports Infectious Disease Area Quantification, Highplex FL HALO
A Deep Learning Convolutional Neural Network Can Differentiate Between Helicobacter Pylori Gastritis and Autoimmune Gastritis With Results Comparable to Gastrointestinal Pathologists Franklin M, Schultz F, Tafoya M, Kerwin A, Broehm C, Fischer E, Gullapalli R, Clark D, Hanson J, Martin D 2022 Archives of Pathology & Laboratory Medicine Oncology, Gastroenterology HALO, HALO AI
Interface astrogliosis in†contact sport head impacts and†military blast exposure Babcock K, Abdolmohammadi B, Kiernan P, Mahar I, Cherry J, Alvarez V, Goldstein L, Stein T, McKee, Huber B 2022 Acta Neuropathologica Communications Neruoscience Area Quantification HALO
The GBA1 D409V mutation exacerbates synuclein pathology to differing extents in two alpha-synuclein models Polinski N, Martinez T, Ramboz S, Sasner M, Herberth M, Switzer R, Ahmad S, Pelligrino L, Clark S, Marcus J, Smith S, Dave K, Frasier M 2022 Disease Models & Mechanisms Neuroscience Object Colocalization HALO
Organelle resolved proteomics reveals new chordoma cell surface markers required for proliferation and association with outcome Khan S, Zuccato J, Ignatchenko V, Singh O, Govindarajan M, Waas M, Gao A, Zadeh G, Kislinger T 2022 Research Square Oncology Cytonuclear, Multiplex IHC HALO
Intraoperative abobotulinumtoxinA alleviates pain after surgery and improves general wellness in a translational animal model Cornet S, Carre D, Limana L, Castel D, Meilin S, Horn R, Pons L, Evans S, Lezmi S, Kalinichev M 2022 Research Square Other Area Quantification, Object Colocalization HALO
Immune cell subsets in interface cutaneous immune-related adverse events (cirAEs) associated with anti-PD-1 therapy resemble accute graft vs host disease more than licen planus Cruz G, Kaunitz G, Stein J, Sander I, Hollmann T, Cottrell T, Taube J, Sunshine J 2022 Journal of Cutaneous Pathology Immunology Cytonuclear, Multiplex IHC HALO
Therapeutic impact of BET inhibitor BI 894999 treatment: backtranslation from the clinic Tontsch-Grunt U, Traexler P, Baum A, Musa H, Marzin K, Wang S, Trapani F, Engelhardt H, Solca F 2022 British Journal of Cancer Oncology Classifier, Cytonuclear, Multiplex IHC HALO
Immune and epithelial determinants of age-related risk and alveolar injury in fatal COVID-19 Chait M, Yilmaz M, Shakil S, Ku A, Dogra P, Connors T, Szabo P, Gray J, Wells S, Kubota M, Matsumoto R, Poon M, Snyder M, Baldwin M, Sims P, Saqi A, Farber D, Weisberg S 2022 JCI Insight Infectious Disease Multiplex IHC HALO
Neuropathology and virus in brain of SARS-CoV-2 infected non-human primates Rutkai I, Mayer M, Hellmers L, Ning B, Huang Z, Monjure C, Coyne C, Silvestri R, Golden N, Hensley K, Chandler K, Lehmicke G, Bix G, Maness N, Russell-Lodrigue K, Hu T, Roy C, Blair R, Bohm R, Doyle-Meyers L, Rappaport J, Fisher T 2022 Nature Communications Infectious Disease Area Quantification HALO
Increased apoptotic sensitivity of glioblastoma enables therapeutic targeting by BH3-mimetics Koessinger A, Cloix C, Koessinger D, Heiland D, Bock F, Strathdee K, Kinch K, Martinez-Escardo L, Paul N, Nixon C, Malviya G, Jackson M, Campbell K, Stevenson K, Davis S, Elmasry Y, Ahmed A, O'Prey J, Ichim G, Schnell O, Stewart W, Blyth K, Ryan K, Chalmers A, Norman J, Tait S 2022 Cell Death & Differentiation Oncology HALO
SPOP promotes cervical cancer progress by inducing PD-1 move away from PD-L1 in spatial localization Wu J, Wu Y, Guo Q, Chen S, Wang S, Zhu J, Wu X, Ju X 2022 Research Square Oncology Cytonuclear, Spatial Analysis, Highplex FL, TMA HALO
Hyperpolarized 13C-Pyruvate Metabolism as a Surrogate for Tumor Grade and Poor Outcome in Renal Cell CarcinomaóA Proof of Principle Study Ursprung S, Woitek R, McLean M, Priest A, Crispin-Ortuzar M, Brodie C, Gill A, Gehrung M, Beer L, Riddick A, Field-Rayner J, Grist J, Deen S, Riemer F, Kaggie J, Zaccagna F, Duarte J, Locke M, Frary A, Aho T, Armitage J, Casey R, Mendichovszky I, Welsh S, Barrett T, Graves M, Eisen T, Mitchell T, Warren A, Brindle K, Sala E, Stewart G, Gallagher F 2022 Cancers Oncology Area Quantification, Cytonuclear, Multiplex IHC HALO
A novel soluble epoxide hydrolase vaccine protects murine cardiac muscle against myocardial infarction Kitsuka T, Shiraki A, Oyama J, Nakagami H, Tanaka A, Node K 2022 Scientific Reports Other Figure Maker HALO, HALO AI
C57BL/6J Mice Are Not Suitable for Modeling Severe SARS-CoV-2 Beta and Gamma Variant Infection Currey J, Rabito F, Maness N, Blair R, Rappaport J, Qin X, Kolls J, Srivastava A 2022 Viruses Infectious Disease Cytonuclear, Multiplex IHC HALO
Type I interferon regulates proteolysis by macrophages to prevent immunopathology following viral infection Lee A, Feng E, Chew M, Balint E, Poznanski S, Giles E, Zhang A, Marzok A, Revill S, Vahedi F, Dubey A, Ayaub E, Jimenez-Saiz R, McGrath J, Ritchie T, Jordana M, Jonigk D, Ackermann M, Ask K, Miller M, Richards C, Ashkar A 2022 PLOS Pathogens Infectious Disease Area Quantification, Multiplex IHC, TMA HALO
Dietary Pharmacological Zinc and Copper Enhances Voluntary Feed Intake of Nursery Pigs DeMille C, Burrough E, Kerr B, Schweer W, Gabler N 2022 Frontiers in Animal Science Other Cytonuclear, Multiplex IHC HALO
Epicardium-derived cells organize through tight junctions to replenish cardiac muscle in salamanders Eroglu E, Yen C, Witman N, Elewa A, Araus A, Wang H, Szattler T, Umeano C, Sohlmer J, Goedel A, Simon A, Chien K 2022 Nature Cell Biology Myology ISH/FISH, ISH-IHC/FISH-IF HALO
Sotatercept analog suppresses infammation to reverse experimental pulmonary arterial hypertension Joshi S, Liu J, Bloom T, Atabay E, Kuo T, Lee M, Belecheva E, Spaits M, Grenha R, Maguire M, Frost J, Wang K, Briscoe S, Alaxander M, Herrin B, Castonguay R, Pearsall R, Andre P, Yu P, Kumar R, Li G 2022 Scientific Reports Other Layer Thickness HALO
Spatial transcriptome of a germinal center plasmablastic burst hints at†MYD88/CD79B†mutants-enriched diffuse large B-cell lymphomas L'Imperio V, Morello G, Vegliante M, Cancila V, Bertolazzi G, Mazzara S, Belmonte B, Mangogna A, Balzarini P, Corral L, Lopez G, Di Napoli A, Facchetti F, Pagni F, Tripodo C 2022 European Journal of Immunology Oncology Cytonuclear, Multiplex IHC HALO
Single-cell profling of†human dura and†meningioma reveals cellular meningeal landscape and†insights into†meningioma immune response Wang A, Bowman-Kirigin J, Desai R, Kang L, Patel P, Patel B, Khan S, Bender D, Marlin M, Liu J, Osbun J, Leuthardt E, Chicoine M, Dacey Jr R, Zipfel G, Kim A, DeNardo D, Petti A, Dunn G 2022 Genome Medicine Neuroscience Area Quantification HALO
Multi-scale integrative analyses identify THBS2+†cancer-associated fibroblasts as a key orchestrator promoting aggressiveness in early-stage lung adenocarcinoma Yang H, Sun B, Fan L, Ma W, Xu K, Hall S, Wang Z, Schmid R, Peng R, Marti T, Gao W, Xu J, Yang W, Yao F 2022 Theranostics Oncology Cytonuclear, Multiplex IHC HALO
Automated Cancer Diagnostics via Analysis of Optical and Chemical Images by Deep and Shallow Learning Isberg O, Giunchiglia V, McKenzie J, Takats Z, Jonasson J, Bodvarsdottir S, Thorsteinsdottir M, Xiang Y 2022 Metabolites Oncology HALO, HALO AI
Characterization and Validation of In Vitro and In Vivo Models to Investigate TNF-?-Induced Inflammation in Retinal Diseases Weigelt C, Zippel N, Fuchs H, Rimpela A, Schonberger T, Stierstorfer B, Bakker R, Redemann N 2022 Translational Vision Science & Technology Immunology, Other Area Quantification, Layer Thickness HALO
Pilot Trial of Arginine Deprivation Plus Nivolumab and Ipilimumab in Patients with Metastatic Uveal Melanoma Kraehenbuehl L, Holland A, Armstrong E, O'Shea S, Mangarin L, Chekalil S, Johnston A, Bomalaski J, Erinjeri J, Barker C, Francis J, Wolchok J, Merghoub T, Shoushtari A 2022 Cancers Oncology Cytonuclear, Highplex FL HALO
An in vivo accelerated developmental myelination model for testing promyelinating therapeutics Lariosa-Willingham K, Leunoudakis D, Bragge T, Tolppanen L, Nurmi A, Flanagan M, Gibson J, Wilson D, Stratton J, Lehtimaki K, Miszczuk D 2022 BMC Neuroscience Neuroscience Area Quantification HALO
Nitric oxide favours tumour-promoting inflammation through mitochondria-dependent and -independent actions on macrophages Drehmer D, Luiz J, Hernandez C, Alves-Filho J, Hussell T, Townsend P, Moncada S 2022 Redox Biology Oncology Highplex FL HALO
Maternal Western-Style Diet Impairs Bone Marrow Development and Drives a Hyperinflammatory Phenotype in Hematopoietic Stem and Progenitor Cells in Fetal Rhesus Macaques Sureshchandra S, Chan C, Robino J, Parmelee L, Nash M, Wesolowski S, Pietras E, Friedman J, Takahashi D, Shen W, Hennebold J, Goldman D, Packwood W, Lindner J,Roberts C, Burwitz B, Messaoudi I, Varlamov O 2022 bioRxiv Metabolism Multiplex IHC HALO
Preclinical evaluation of†FAP?2286 for†fbroblast activation protein targeted radionuclide imaging and†therapy Zboralski D, Hoehne A, Bredenbeck A, Schumann A, Nguyen M, Schneider E, Ungewiss J, Paschke M, Haase C, von Hacht J, Kwan T, Lin K, Lenore J, Harding T, Xiao J, Simmons A, Mohan A, Beindorff N, Reineke U, Smerling C, Osterkamp F 2022 European Journal of Nuclear Medicine and Molecular Imaging Oncology Cytonuclear, Multiplex IHC HALO
Different types of reactions to E7386 among colorectal cancer patient?derived organoids and corresponding CAFs Imai T, Naruse M, Ochiai M, Matsumoto K, Ikeda S, Kani M, Kato Y, Hirayama A, Sogo T, Hori Y, Yokoi A, Ochiai A 2022 Oncology Letters Oncology Area Quantification HALO
Deep Learning Facilitates Distinguishing Histologic Subtypes of Pulmonary Neuroendocrine Tumors on Digital Whole-Slide Images Ilie M, Benzaquen J, Tourniaire P, Heeke S, Ayache N, Delingette H, Long-Mira E, Lassalle S, Hamila M, Fayada J, Otto J, Cohen C, Gomez-Caro A, Berthet J, Marquette C, Hofman V, Bontoux C, Hofman P 2022 Cancers Oncology HALO, HALO AI
Prognostic Integrated Image-Based Immune and Molecular Profiling in Early-Stage Endometrial Cancer Horeweg N, de Bruyn M, Nout R, Stelloo E, Kedzierska K, Leon-Castillo A, Plat A, Mertz K, Osse M, Jurgenliemk-Schulz I, Lutgens L, Jobsen J, van der Steen-Banasik E, Smit V, Creutzberg C, Bosse T, Nijman H, Koelzer V, Church D 2020 Cancer Immunology Research Oncology Cytonuclear, Multiplex IHC, TMA HALO, HALO AI
Comparing Deep Learning and Immunohistochemistry in Determining the Site of Origin for Well-Differentiated Neuroendocrine Tumors Redemann J, Schultz F, Martinez C, Harrell M, Clark D, Martin D, Hanson J 2020 Journal of Pathology Informatics Oncology Cytonuclear, TMA HALO, HALO AI
Randomized Controlled Trial of the Gastrin/CCK2†Receptor Antagonist Netazepide in Patients with Barrett's Esophagus Abrams J, Del Portillo A, Hills C, Compres G, Friedman R, Cheng B, Poneros J, Lightdale C, Del La Rue R, di Pietro M, Fitzgerald R, Sepulveda A, Wang T 2021 Cancer Prevention Research Cytonuclear, Multiplex IHC HALO, HALO AI
Myeloid cell-driven nonregenerative pulmonary scarring is conserved in multiple nonhuman primate species regardless of SARS-CoV-2 infection modality Fears A, Beddingfield B, Chirichella N, Slisarenko N, Kileen S, Redmann R, Goff K, Spencer S, Picou B, Golden N, Bush D, Branco L, Boisen M, Gao H, Montefiori D, Blair R, Doyle-Meyers L, Russel-Lodrigue K, Maness N, Roy C 2021 bioRxiv Area Quantification, Highplex FL HALO, HALO AI
Independent Prognostic Value of Intratumoral Heterogeneity and Immune Response Features by Automated Digital Immunohistochemistry Analysis in Early Hormone Receptor-Positive Breast Carcinoma Zilenaite D, Rasmusson A, Augulis R, Besuparis J, Laurinaviciene A, Plancoulaine B, Ostpenko V, Laurinavicius 2020 Frontiers in Oncology Oncology Multiplex IHC, Figure Maker HALO, HALO AI
Tau isoforms are differentially expressed across the hippocampus in chronic traumatic encephalopathy and Alzheimerís disease Cherry J, Esnault C, Baucom Z, Tripodis Y, Huber B, Alvarez V, Stein T, Dickson D, McKee A 2021 Acta Neuropathologica Communications Neuroscience HALO, HALO AI
3íUTR-directed, kinase proximal mRNA decay inhibits C/EBP? phosphorylation/activation to suppress senescence in tumor cells Salotti J, Karim B, Misra S, Hu L, Basu S, Martin N, Luke B, Saylor K, Andresson T, Scheiblin D, Lockett S, Tessarollo L, Johnson P 2022 bioRxiv Oncology Classifier, Cytonuclear HALO, HALO AI
CK2 signaling from TOLLIP-dependent perinuclear endosomes is an essential feature of†KRAS†mutant cancers Basu S, Luke B, Karim B, Martin N, Lockett S, Das S, Andresson T, Saylor K, Kozlov S, Bassel L, Esposito D, Johnson P 2022 bioRxiv Oncology Area Quantification HALO, HALO AI
Maternal obesity during pregnancy leads to adipose tissue ER stress in mice via miR-126-mediated reduction in Lunapark de Almeida-Faria J, Duque-Guimares D, Ong T, Pantaleao L, Carpenter A, Loche E, Kusinki L, Ashmore T, Antrobus R, Bushell M, Fernandez-Twinn, Ozanne S 2021 Diabetologia Metabolism HALO, HALO AI
Integrated†Analysis†Of†Immunotherapy†Treated†Clear†Cell†Renal†Cell†Carcinomas:†An†Exploratory†Study Sobottka B, Nienhold R, Nowak M, Hench J, Haeuptle P, Frank A, Sachs M, Kahraman A, Moch H, Koelzer V, Mertz K 2022 Journal of Immunotherapy Immuno-oncology Cytonuclear, Multiplex IHC, Figure Maker HALO, HALO AI
Excessive immunosuppression by regulatory T cells antagonizes T cell response to schistosome infection in PD-1-deficient mice Lu L, Li T, Feng X, Liu Z, Liu Y, Chao T, Gu Y, Huang R, Zhang F, He L, Zhou B, Kong E, Liu Z, 2022 PLOS Pathogens Immunology, Other Area Quantification HALO
Orchestrating the Dermal/Epidermal Tissue Ratio during Wound Healing by Controlling the Moisture Content Tuca A, de Mattos I, Funk M, Winter R, Palackic A, Groeber-Becker F, Kruse D, Kukla F, Lemarchand T, Kamolz L 2022 Biomedicines Other Classifier HALO
Restoring Pro-healing/remodeling- associated M2a/c Macrophages using ON101 Accelerates Diabetic Wound Healing Lin C, Chen C, Huang W, Chen Y, Chen S, Chou H, Hung C, Chen W, Lu C, Nian S, Chen S, Chang H, Chang V, Liu L, Kuo M, Chang S 2022 JID Innovations Other Area Quantification, Cytonuclear HALO
CD4+†T helper 2 cells suppress breast cancer by inducing terminal differentiation Boieri M, Malishkevich A, Guennoun R, Marchese E, Kroon S, Trerice K, Awad M, Park J, Iyer S, Kreuzer J, Haas W, Rivera M, Demehri S 2022 Journal of Experimental Medicine Immuno-oncology Cytonuclear, Highplex FL HALO
A lncRNA signature associated with tumor immune heterogeneity predicts distant metastasis in locoregionally advanced nasopharyngeal carcinoma Liang Y, Zhang Y, Tan X, Qiao H, Liu S, Tang L, Mao Y, Chen L, Li W, Zhou G, Zhao Y, Li J, Li Q, Huang S, Gong S, Zheng Z, Li Z, Sun Y, Jiang W, Ma J, Li Y, Liu N 2022 Nature Communications Immuno-oncology Classifier, Multiplex IHC, Registration HALO
Ginkgo Biloba Extract Reduces Cardiac and Brain Inflammation in Rats Fed a HFD and Exposed to Chronic Mental Stress through NF-?B Inhibition Zhang L, Li G, Tao S, Xia P, Chaudhry N, Kaura S, Stone S, Liu M 2022 Mediators of Inflammation Immunology Area Quantification HALO
Prognostic image-based quantification of CD8CD103 T cell subsets in high-grade serous ovarian cancer patients Paijens S, Vledder A, Loiero D, Duiker E, Bart J, Hendriks A, Jalving M, Workel H, Hollema H, Werner N, Plat A, Wisman G, Yigit R, Arts H, Kruse A, de Lange N, Koelzer V, Bruyn M, Nijman H 2021 OncoImmunology Immuno-oncology Cytonuclear, Multiplex IHC, TMA HALO, HALO AI
Higher proportions of CD39+ tumorresident cytotoxic T cells predict recurrence-free survival in patients with stage III melanoma treated with adjuvant immunotherapy Attrill G, Owen C, Ahmed T, Vergara I, Colebatch A, Conway J, Nahar K, Thompson J, da Silva I, Carlino M, Menzies A, Lo S, Palendira U, Scolyer R, Long G, Wilmott J 2022 Journal of Immuno Therapy of Cancer Immuno-oncology Cytonuclear, Spatial Analysis, Highplex FL HALO
TGF?1 Induces Senescence and Attenuated VEGF Production in Retinal Pericytes Avarmovic D, Archaimbault S, Kemble A, Gruener S, Lazendic M, Westenskow P 2022 Biomedicines Other ISH/FISH HALO
Prenatal di-(2-ethylhexyl_ phthalate exposure induced myocardial cytotoxicity via the regulation of the NRG1-dependent ErbB2/ErbB4-PI3K/AKT signaling pathway in fetal mice Yu D, Zhu D, Wang X, Li B, Li J, Lu P, Ji Y, Wang X 2022 Ecotoxicology and Environmental Safety Other Multiplex IHC HALO
Satellite repeat RNA expression in epithelial ovarian cancer associates with a tumor immunosuppressive phenotype Porter R, Sun S, Flores M, Berzolla E, You E, Phillips I, KC N, Desai N, Tai E, Szabolcs A, Lang E, Pankaj A, Raabe M, Thapar V, Xu K, Nieman L, Rabe D, Kolin D, Stover E, Pepin D, Stott S, Deshpande V, Liu J, Solovyov A, Matulonis U, Greenbaum B, Ting D 2022 The Journal of Clinical Investigation Immuno-oncology ISH/FISH, ISH-IHC/FISH-IF HALO
Distinct Encoding of Reward and Aversion by Peptidergic BNST Inputs to the VTA Soden M, Yee J, Cuevas B, Rastani A, Elum J, Zweifel L 2022 Frontiers in Neural Circuits Neuroscience ISH/FISH HALO
ATG7 is a haploinsufficient repressor of tumor progression and promoter of metastasis Long J, Kania E, McEwan D, Barthet V, Brucoli M, Ladds M, Nossing C, Ryan K 2022 Proceedings of the National Academy of Sciences Oncology, Other Area Quantification HALO
Effects of Extracorporeal Shockwave Therapy on Functional Recovery and Circulating miR-375 and miR-382-5p after Subacute and Chronic Spinal Cord Contusion Injury in Rats Ashmwe M, Posa K, Ruhrnossl A, Heinzel J, Heimel P, Mock M, Schadl B, Keibl C, Couillard-Despres S, Redl H, Mittermayr R, Hercher D 2022 Biomedicines Neuroscience, Other Classifier, Multiplex IHC HALO
Baseline and post-treatment biomarkers of resistance to anti-PD-1 therapy in acral and mucosal melanoma: an observational study Shui I, Liu X, Zhao Q, Kim S, Sun Y, Yearley J, Choudhury T, Webber A, Krepler C, Cristescu R, Lee J 2022 Journal for ImmunoTherapy of Cancer Immuno-oncology Cytonuclear, Highplex FL HALO
Spatial meta-transcriptomics reveal associations of intratumor bacteria burden with lung cancer cells showing a distinct oncogenic signature Wong-Rolle A, Dong Q, Zhu Y, Divakar P, Hor J, Kedei N, Wong M, Tillo D, Conner E, Rajan A, Schrump D, Jim C, Germain R, Zhao C 2022 Journal for ImmunoTherapy of Cancer Immuno-oncology Cytonuclear, Multiplex IHC HALO
SOX9+ malignant cells define a poor prognosis subtype of Glioma with tumor-associated macrophage recruitment Yu S, Ma C, Wang H, Yu B, Luan Y, Xia Z 2022 Research Square Immuno-oncology Cytonuclear, Multiplex IHC HALO
Exposure modality influences viral kinetics but not respiratory outcome of COVID-19 in multiple nonhuman primate species Fears A, Beddingfield B, Chirichella N, Slisarenko N, Kileen S, Redmann R, Goff K, Spencer S, Picou B, Golden N, Midkiff C, Bush D, Branco L, Boisen M, Gao H, Montefiori D, Blair R, Doyle-Meyers L, Russel-Lodrigue K, Maness N, Roy C 2022 PLOS Pathogens Infectious Disease Highplex FL HALO
The combination of gene hyperamplification and PD-L1 expression as a biomarker for the clinical benefit of tislelizumab in gastric/gastroesophageal junction adenocarcinoma Lu Z, Yang S, Luo X, Shi Y, Lee J, Deva S, Liu T, Chao Y, Zhang Y, Huang R, Xu Y, Shen Z, Shen L 2022 Gastric Cancer Immuno-oncology Classifier, Multiplex IHC HALO
Combined Blockade of GARP:TGF-?1 and PD-1 Increases Infiltration of T Cells and Density of Pericyte-Covered GARP+†Blood Vessels in Mouse MC38 Tumors Bertrand C, Van Meerbeeck P, de Streel G, Vaherto-Bleeckx N, Benhaddi F, Rouaud L, Noel A, Coulie P, van Baren N, Lucas S 2022 Frontiers of Immunology Immuno-oncology Cytonuclear, Object Colocalization HALO
gp96 Expression in Gliomas and Its Association with Tumor Malignancy and T Cell Infiltrating Level Li C, Wang Y, Long L, Zhang P, Zhang Y, Ji N 2022 Hindawi Journal of Oncology Immuno-oncology Spatial Analysis, Highplex FL, Figure Maker HALO
Multiplexed immunofluorescence analysis of CAFmarkers, EZH2 and FOXM1 in Gastric Tissue: Associations with Clinicopathological Parameters and Clinical Outcomes Sun H, Wang X, Wang X, Tan C, Weng W, Zhang M, Ni S, Wang L, Huang D, Sheng W, Xu M 2022 Research Square Oncology Cytonuclear, Highplex FL HALO
Cancer-associated fibroblasts require proline synthesis by PYCR1 for the deposition of pro-tumorigenic extracellular matrix Kay E, Paterson K, Riero-Domingo C, Sumpton D, Dabritz J, Tardito S, Boldrini C, Hernandez-Fernaud J, Athineos D, Dhayade S, Stepanova E, Gjerga E, Neilson L, Lilla S, Hedley A, Koulouras G, McGregor G, Jamieson C, Johnson R, Park M, Kirschner K, Miller C, Kamphorst J, Loayza-Puch F, Saez-Rodriguez J, Mazzone M, Blyth K, Zagnoni M, Zanivan S 2022 Nature Metabolism Oncology, Metabolism Cytonuclear, Multiplex IHC, Highplex FL HALO
Deep-learning-based classification of desmoplastic reaction on H&E predicts poor prognosis in oesophageal squamous cell carcinoma Kouzu K, Nearchou I, Kajiwara Y, Tsujimoto H, Lillard K, Kishi Y, Ueno H 2022 Histopathology Oncology HALO, HALO AI
Cutaneous Lymphocyte Antigen (CLA) is a potential therapeutic target in Cutaneous T Cell Lymphoma Peru S, Prochazkova-Carlotti M, Cherrier F, Velazquez J, Richard E, Idrissi Y, Cappellen D, Azzi-Martin L, Pham-Ledard A, Beylot-Barry M, Merlio J, Poglio S 2022 Journal of Investigative Dermatology Immuno-oncology Area Quantification HALO
Loss of EMP1 promotes the metastasis of human bladder cancer cells by promoting migration and conferring resistance to ferroptosis through activation of PPAR gamma signaling Liu S, Shi J, Wang L, Huang Y, Zhao B, Ding H, Liu Y, Wang W, Chen Z, Yang J 2022 Free Radical Biology and Medicine Oncology Area Quantification HALO
Discovery of†a†novel ALK/ROS1/FAK inhibitor, APG-2449, in†preclinical non-small cell lung cancer and†ovarian cancer models Fang D, Tao R, Wang G, Li Y, Zhang K, Xu C, Zhai G, Wang Q, Wang J, Tang C, Min P, Xiong D, Chen J, Wang S, Yang D, Zhai Y 2022 BMC Cancer Oncology Multiplex IHC HALO
Integrated single-cell analyses decode the developmental landscape of the human fetal spine Yu H, Tang D, Wu H, Li C, Lu Y, He F, Zhang X, Yang Y, Shi W, Hu W, Zeng Z, Dai W, Ou M, Dai Y 2022 iScience Other Highplex FL HALO
Cell graph neural networks enable the precise prediction of patient survival in gastric cancer Wang Y, Wang Y, Hu C, Li M, Fan Y, Otter N, Sam I, Gou H, Hu Y, Kwok T, Zalcberg J, Boussioutas A, Daly R, Montufar G, Lio P, Xu D, Webb G, Song J 2022 Precision Oncology Oncology Multiplex IHC HALO
Spartalizumab or placebo in combination with dabrafenib and trametinib in patients with†BRAF†V600-mutant melanoma: exploratory biomarker analyses from a randomized phase 3 trial (COMBI-i) Tawbi H, Robert C, Brase J, Gusenleitner D, Gasal E, Garrett J, Savchenko A, Gorgun G, Flaherty K, Ribas A, Dummer R, Schadendorf D, Long G, Nathan P, Ascierto P 2022 Journal for ImmunoTherapy of Cancer Oncology Multiplex IHC, Spatial Analysis HALO
Establishing a multiplex imaging panel to study T cell development in the thymus in mouse Allam A, Russell S 2022 STAR Protocols Immunology Highplex FL HALO
Developing T cells form an immunological synapse for passage through the ?-selection checkpoint Allam A, Charnley M, Pham K, Russel S 2022 Journal of Cell Biology Immunology Highplex FL HALO
Sensory neurons display cell-type-specific vulnerability to loss of neuron-glia interactions Elbaz B, Yang L, Vardy M, Isaac S, Rader B, Kawaguchi R, Traka M, Woolf C, Renthal W, Popko B 2022 Cell Reports Neuroscience Axon HALO
MMO-Net (Multi-Magnification Organ Network): A use case for Organ Identification using Multiple Magnifications in Preclinical Pathology Studies Serna C, Romero-Palomo F, Arcadu F, Funk J, Schumacher V, Janowczyk A 2022 Journal of Pathology Informatics Other HALO
Endothelial cell death after ionizing radiation does not impair vascular structure in mouse tumor models Kaeppler J, Chen J, Buono M, Vermeer J, Kannan P, Cheng W, Voukantsis D, Thompson J, Hill M, Allen D, Gomes A, Kersemans V, Kinchesh P, Smart S, Buffa F, Nerlov C, Muschel R, Markelc B 2022 EMBO Reports Oncology Spatial Analysis, Highplex FL HALO
Non-canonical EphA2 activation underpins PTEN-mediated metastatic migration and poor clinical outcome in prostate cancer Sachdeva A, Hart C, Kim K, Tawadros T, Oliveira P, Shanks J, Brown M, Clarke N 2022 British Journal of Cancer Oncology Highplex FL HALO
Approaches to spatially resolving the tumour immune microenvironment of hepatocellular carcinoma Marsh-Wakefield F, Ferguson A, Liu K, Santhakumar C, McCaughan G, Palendira U 2022 Therapeutic Advances in Medical Oncology Review Multiplex IHC, Spatial Analysis, Highplex FL HALO
Intact HIV proviruses persist in the brain despite viral suppression with ART Cochrane C, Angelovich T, Byrnes S, Waring E, Guanizo A, Trollope G, Zhou J, Vue J, Senior L, Wanicek E, Eddine J, Gartner M, Jenkins T, Gorry P, Brew B, Lewin S, Estes J, Roche M, Churchill M 2022 Annals of Neurology Infectious Disease Multiplex IHC HALO
Isoniazid and Rifapentine Treatment effectively reduces persistent M. tuberculosis infection 2 in macaque lungs Sharan R, Ganatra S, Singh D, Cole J, Foreman T, Thippeshappa R, Peloquin C, Shivanna V, Gonzalez O, Day C, Gandhi N, Dick E, Hall-Ursone S, Mehra S, Schlesinger L, Rengarajan J, Kaushal D 2022 Journal of Clinical Investigation Infectious Disease Classifier HALO
Naproxen chemoprevention promotes immune activation in Lynch syndrome colorectal mucosa Reyes-Uribe L, Wu W, Gelincik O, Bommi PV, Francisco-Cruz A, Solis LM, Lynch PM, Lim R, Stoffel EM, Kanth P, Samadder NJ, Mork ME, Taggart MW, Milne GL, Marnett LJ, Vornik L, Liu DD, Revuelta M, Chang K, You YN, Kopelovich L, Wistuba II, Lee JJ, Sei S, Shoemaker RH, Szabo E, Richmond E, Umar A, Perloff M, Brown PH, Lipkin SM, Vilar E 2020 Gut Oncology Classifier, Cytonuclear HALO
Age-associated expression of p21 and p53 during human wound healing Chia CW, Sherman-Baust CA, Larson SA, Pandey R, Withers R, Karikkineth AC, Zukley LM, Campisi J, Egan JM, Sen R, Ferrucci L 2021 Aging Cell Dermatology Area Quantification, ISH/FISH, Multiplex IHC HALO
Radioprotective effect of X-ray abdominal FLASH irradiation: Adaptation to oxidative damage and inflammatory response may be benefiting factors Zhu H, Xie D, Yang Y, Huang S, Gao X, Peng Y, Wang B, Wang J, Xiao D, Wu D, Li C, Li C, Qian C, Deng X 2022 Medical Physics Oncology, Other Multiplex IHC HALO
Genetically engineered microglia-like cells have therapeutic potential for neurodegenerative 2 disease Plasschaert R, DeAndrade M, Hull F, Nguyen Q, Peterson T, Yan A, Loperfido M, Baricordi C, Barbarossa L, Yoon J, Dogan Y, Unnisa Z, Schindler J, van Til N, Biasco L, Mason C 2021 bioRxiv Neuroscience Highplex FL HALO
Addition of camrelizumab to docetaxel, cisplatin, and radiation therapy in patients with locally advanced esophageal squamous cell carcinoma: a phase 1b study Zhang W, Yan C, Zhang T, Chen X, Dong J, Zhao J, Han D, Wang J, Zhao G, Cao F, Zhou D, Jiang H, Tang P, Zhao L, Yuan Z, Wang Q, Wang P, Pang Q 2021 OncoImmunology Oncology Highplex FL HALO
Upregulation of C/EBPa Inhibits Suppressive Activity of Myeloid Cells and Potentiates Antitumor Response in Mice and Patients with Cancer Hashimoto A, Sarker D, Reebye V, Jarvis S, Sodergren M, Kossenkov A, Raulf N, Vasara J, Andrikakou P, Meyer T, Huang K, Plummer R, Chee C, Spalding D, Pai M, Khan S, Pinato D, Sharma R, Basu B, Palmer D, Ma Y, Evans J, Habib R, Martirosyan A, Elasri N Reynaud A, Rossi J, Cobbold M, Habib N, Gabrilovich D 2021 Clinical Cancer Research Oncology, Immuno-oncology Multiplex IHC HALO
Spatial Distribution and Predictive Significance of Dendritic Cells and Macrophages in Esophageal Cancer Treated With Combined Chemoradiotherapy and PD-1 Blockade Ma X, Guo Z, Wie X, Zhao G, Han D, Zhang T, Chen X Cao F, Dong J, Zhao L, Yuan Z, Wang P, Pang Q, Yan C, Zhang W 2021 Frontiers in Immunology Oncology Spatial Analysis, Highplex FL HALO
Hyperpolarised†13C-MRI identifies the emergence of a glycolytic cell population within intermediate-risk human prostate cancer Sushentsev N, McLean M, Warren A, Benjamin A, Brodie C, Frary A, Gill A, Jones J, Kaggie J, Lamb B, Locke M, Miller J, Mills I, Priest A, Robb F, Shah N, Schulte R, Graves M, Gnanapragasam V, Brindle K, Barrett T, Gallacher F 2022 Nature Communications Oncology ISH/FISH, Membrane, Multiplex IHC HALO
Antibody-drug conjugate MORAb-202 exhibits long-lasting antitumor efficacy in TNBC PDx models Furuuchi K, Rybinski K, Fulmer J, Moriyama T, Drozdowski B, Soto A, Fernando S, Wilson K, Milinichik A, Dula M, Tanaka K, Cheng X, Albone E, Uenaka T 2021 Cancer Science Oncology Multiplex IHC HALO
DS-7300a, a DNA Topoisomerase I Inhibitor, DXd-based Antibody-Drug Conjugate 2 Targeting B7-H3 Exerts Potent Antitumor Activities in Preclinical Models Yamato M, Hasegawa J, Maejima T, Hattori C, Kumagai K, Watanabe A, Nishiya Y, Shibutani T, Aida T, Hayakawa I, Nakada T, Abe Y, Agatsuma T 2022 Molecular Cancer Therapeutics Oncology Multiplex IHC HALO
Prostate cancer androgen receptor activity dictates efficacy of Bipolar Androgen Therapy Sena L, Kumar R, Sanin D, Thompson E, Rosen D, Dalrymple S, Antony L, Yang Y, Comes-Alexandre C, Hicks J, Jones T, Bowers K, Eskra J, Meyers J, Gupta A, Skaist A, Yegnasubramanian S, Luo J, Brennen W, Kachhap S, Antonarakis E, De Marzo A, Isaacs J, Markowski M, Denmeade S 2022 medRxiv Oncology Classifier, Cytonuclear, Multiplex IHC, Registration HALO
Intraoperative fluorescence imaging with aminolevulinic acid detects grossly occult breast cancer: a phase II randomized controlled trial Ottolino-Perry K, Shahid A, DeLuca S, Son V, Sukhram M, Meng F, Liu Z, Rapic S, Anantha N, Wang S, Chamma E, Gibson C, Medeiros P, Majeed S, Chu A, Wignall O, Pizzolato A, Rosen C, Teene L, Starr-Dunham D, Kulbatski I, Panzarella T, Done S, Easson A, Leong W, DaCosta R 2021 Breast Cancer Research Oncology Classifier, Area Quantification HALO
Modulation of the Human Pancreatic Ductal Adenocarcinoma Immune Microenvironment by Stereotactic Body Radiotherapy Mills B, Qiu H, Drage M, Chen C, Mathew J, Garrett-Larsen J, Ye J, Uccello T, Murphy J, Belt B, Lord E, Katz A, Linehan D, Gerber S 2021 Clinical Cancer Research Oncology Classifier, Spatial Analysis, Highplex FL HALO
Senescence-Associated Molecules and Tumor-Immune-Interactions as Prognostic Biomarkers in Colorectal Cancer Kellers F, Fernandez A, Konykiewitz B, Schindeldecker M, Tagscherer K, Heintz A, Jesinghaus M, Roth W, Foersch S 2022 Frontiers in Medicine Oncology Classifier, Multiplex IHC, Spatial Analysis, Registration, TMA HALO
A survey on artificial intelligence in histopathology image analysis Abdelsamea M, Zidan U, Senousy Z, Gaber M, Rakha E, Ilyas M 2022 WIREs Data Mining and Knowledge Discovery Review Classifier, Cytonuclear, Figure Maker, TMA HALO
Automated recognition of glomerular lesions in the kidneys of mice by using deep learning Akatsuka A, Horai Y, Akatsuka A 2022 Journal of Pathology Informatics Other Classifier HALO, HALO AI
Tau Pathology in Chronic Traumatic Encephalopathy is Primarily Neuronal Butler M, Dixon E, Stein T, Alvarez V, Huber B, Buckland M, McKee A, Cherry J 2022 Journal of Neuropathology & Experimental Neurology Neuroscience Multiplex IHC, Spatial Analysis, Highplex FL HALO, HALO AI
Chemoradiation-induced alteration of programmed death-ligand 1, CD8+ tumor-infiltrating lymphocytes and mucin expression in rectal cancer Baretti M, Zhu Q, Fu W, Meyer J, Wang H, Anders R, Azad N 2022 Oncotarget Oncology Multiplex IHC, Spatial Analysis HALO
Two independent modes of kidney stone suppression achieved by AIM/CD5L and KIM-1 Matsuura K, Maehara N, Hirota A, Eguchi A, Yasuda K, Taniguchi K, Nishijima A, Matsuhashi N, Shiga Y, Ishii R, Iguchi Y, Tanabe K, Arai S, Miyazaki T 2022 Communications Biology Other Area Quantification, Figure Maker HALO
Dynamic and adaptive cancer stem cell population admixture in colorectal neoplasia Vasquez E, Nasreddin N, Valbuena G, Mulholland E, Belnoue-Davis H, Eggington H, Schenck R, Wouters V, Wirapati P, Gilroy K, Lannagan R, Flanagan D, Nujumudeen A, Omwenga S, McCorry A, Easton A, Koelzer V, East J, Morton D, Trusolino L, Maughan T, Campbell A, Loughrey M, Dunne P, Tsantoulis P, Juels D, Tejpar S, Sansom O, Leedham S 2022 Cell Stem Cell Oncology Highplex FL, Registration HALO
MYC sensitises cells to apoptosis by driving energetic demand. Edwards-Hicks J, Su H, Mangolini M, Yoneten K, Wills J, Rodriguez-Blanco G, Young C, Cho K, Barker H, Muir M, Guerrieri A, Li X, White R, Manasterski P, Mandrou E, Wills K, Chen J, Abraham E, Sateri K, Qian B, Bankhead P, Arends M, Gammoh N, von Kriegsheim A, Patti G, Sims A, Acosta J, Brunton V, Kranc K, Christophorou M, Pearce E, Ringshausen I, Finch A 2022 Nature Communications Oncology, Metabolism Classifier HALO
The addition of FAIMS increases targeted proteomics sensitivity from FFPE tumor biopsies Sweet S, Chain D, Yu W, Martin P, Rebelatto M, Chambers A, Cecchi F, Kim Y 2022 Scientific Reports Other HALO, HALO AI
Glycosphingolipids are mediators of cancer plasticity through independent signaling pathways Cumin C, Huang Y, Rossdam C, Ruoff F, Cespedes S, Liang C, Lombardo F, Coelho R, Rimmer N, Konantz M, Lopez M, Alam S, Schmidt A, Calabrese D, Fedier A, Vlajnic T, Itzstein M, Templin M, Buettner F, Everest-Dass A, Heinzelmann-Schwarz V, Jacob F 2022 Cell reports Oncology Classifier, Multiplex IHC HALO
The Key Molecular Mechanisms of Sini Decoction Plus Ginseng Soup to Rescue Acute Liver Failure: Regulating PPAR? to Reduce Hepatocyte Necroptosis? He Y, Zhang Y, Zhang J, Hu X 2022 Journal of Inflammation Research Other Area Quantification HALO
Bright-Field Multiplex Immunohistochemistry Assay for Tumor Microenvironment Evaluation in Melanoma Tissues Ugolini F, Pasqualini E, Simi S, Baroni G, Massi D 2022 Cancers Other Multiplex IHC HALO, HALO Link
Adult re-expression of IRSp53 rescues NMDA receptor function and social behavior in IRSp53-mutant mice Noh Y, Yook C, Kang J, Lee S, Kim Y, Yang E, Kim H, Kim E 2022 Communications Biology Neuroscience ISH/FISH, Figure Maker HALO
Immune evasion before tumour invasion in early lung squamous carcinogenesis Mascaux C, Angelova M, Vasaturo A, Beane J, Hijazi K, Anthoine G, Rothe F, Willard-Gallo K, Haller A, Ninane V, Burny A, Sculier J-P, Spira A, Galon J 2019 Nature Immuno-oncology, Oncology Multiplex IHC HALO
Knockdown of ZBTB11 impedes R-loop elimination and increases the sensitivity to cisplatin by inhibiting DDX1 transcription in bladder cancer Chen L, Liu Z, Tang H, Zhou Z, Chen J, Ma Z, Deng M, Li X, Wu Y, Zheng L, Zhou L, Zheng X, Liu Z 2022 Cell Proliferation Oncology Multiplex IHC, Highplex FL, Figure Maker HALO
LncRNA scaRNA2 bridges DNA end-resection to homologous recombination repair mediated chemoradioresistance Yang Y, Chen Y, Shen H, Liu T, Cao K, Wan Z, Du Z, Wang H, Yu Y, Ma S, Li B, Zhang W, Cai J, Gao F 2022 Research Square Oncology Highplex FL, TMA HALO
Tumor-infiltrated activated B cells suppress liver metastasis of colorectal cancers Xu Y, Wei Z, Feng M, Zhu D, Mei S, Wu Z, Feng Q, Chang W, Ji M, Liu C, Zhu Y, Shen L, Yang F, Chen Y, Feng Y, Xu J, Zhu D 2022 Cell Reports Oncology, Immuno-oncology Multiplex IHC, Highplex FL HALO
Tumor immune contexture is a determinant of anti-CD19 CAR T cell efficacy in large B cell lymphoma Scholler N, Perbost R, Locke F, Jain M, Turcan S, Danan C, Chang E, Neelapu S, Miklos D, Jacobson C, Lekakis L, Lin Y, Ghobadi A, Kim J, Chou J, Plaks V, Wang Z, Xue A, Mattie M, Rossi J, Bot A, Galon J 2022 Nature Medicine Immuno-oncology Multiplex IHC, Figure Maker HALO
Multimodal integration of radiology, pathology and genomics for prediction of response to PD-(L)1 blockade in patients with non-small cell lung cancer Vanguri R, Luo J, Aukerman A, Egger J, Fong C, Horvat N, Pagano A, Araujo-Filho J, Geneslaw L, Rizvi H, Sosa R, Boehm K, Yang S, Bodd F, Ventura K, Hollmann, T, Ginsberg M, Gao J, MSK MIND Consortium, Hellmann M, Sauter J, Shah S 2022 Nature Cancer Immuno-oncology HALO, HALO AI
A Beta-containing bivalent SARS-CoV-2 spike protein vaccine candidate with AS03 elicits durable and broad neutralization of variants including Omicron in macaques and confers protection in hamsters Berry C, Pavot V, Anosova N, Kishko M, Huang D, Tibbitts T, Raillard A, Gautheron S, Cummings S, Bangari D, Kar S, Atyeo C, Deng Y, Alter G, Gutzeit C, Koutsoukos M, Chicz R, Lecouturier V 2022 Research Square Infectious Disease Multiplex IHC HALO
Combined genetic deletion of GDF15 and FGF21 has modest effects on body weight, hepatic steatosis and insulin resistance in high fat fed mice Patel S, Haider A, Alvarez-Guaita A, Bidault G, Moustafa J, Guiu-Jurado E, Tadross J, Warner J, Harrison J, Virtue S, Scurria F, Zvetkova I, Bluher M, Small K, O'Rahilly S, Savage D 2022 Molecular Metabolism Metabolism Vacuole HALO
Immune cells in mesothelioma microenvironment simplistic marker of response to nivolumab plus ipilimumab Disselhorst M, Lubeck Y, van der Noort V, Quispel-Janssen J, Seignette I, Sanders J, Peters D, Hooijberg E, Baas P 2022 Lung Cancer Oncology Multiplex IHC, Registration HALO
In situ†mass spectrometry imaging reveals heterogeneous glycogen stores in human normal and cancerous tissues Young L, Conroy L, Clarke H, Hawkinson T, Bolton K, Sanders W, Chang J, Webb M, Alilain W, Vander Kooi C, Drake R, Andrews D, Badgett T, Wagner L, Allison D, Sun R, Gentry M 2022 EMBO Molecular Medicine Oncology, Metabolism Multiplex IHC HALO
Transcriptional and functional analyses of neoantigen-specific CD4 T cells during a profound response to anti-PD-L1 in metastatic Merkel cell carcinoma Church C, Pulliam T, Longino N, Park S, Smythe K, Makarov V, Riaz N, Jing L, Amezquita R, Campbell J, Gottardo R, Pierce R, Choi J, Chan T, Koelle D, Nghiem P 2022 Journal for ImmunoTherapy of Cancer Oncology, Immuno-oncology Highplex FL HALO
Modelling aggressive prostate cancers of young men in immune-competent mice, driven by isogenic†Trp53†alterations and†Pten†loss Mejia-Hernandez J, Keam S, Saleh R, Muntz F, Fox S, Byrne D, Kogan A, Pang L, Huynh J, Litchfield C, Caramia F, Lozano G, He H, You J, Sandhu S, Williams S, Haupt Y, Haupt S 2022 Cell Death & Disease Oncology Multiplex IHC, Highplex FL, Figure Maker HALO
In vivo tumor immune microenvironment phenotypes correlate with inflammation and vasculature to predict immunotherapy response Sahu A, Kose K, Kraehenbuehl L, Byers C, Holland A, Tembo T, Santella A, Alfonso A, Li M, Cordova M, Gill M, Fox C, Gonzalez S, Kumar P, Wang A, Kurtansky N, Chandrani P, Yin S, Mehta P, Navarrete-Dechent C, Peterson G, King K, Dusza S, Yang N, Liu S, Phillips W, Guitera P, Rossi A, Halpern A, Deng L, Pulitzer M, Marghoob A, Chen C, Merghoub T, Rajadhyaksha M 2022 Nature Communications Immuno-oncology Highplex FL, Figure Maker HALO
Combination of T cell-redirecting bispecific antibody ERY974 and chemotherapy reciprocally enhances efficacy against non-inflamed tumours Sano Y, Azuma Y, Tsunenari T, Kayukawa Y, Shinozuka J, Fujii E, Amano J, Nishito Y, Maruyama T, Kinoshita Y, Sakamoto Y, Yoshida A, Miyazaki Y, Sato Y, Teramoto-Seida C, Ishiguro T, Tanaka T, Kitazawa T, Endo M 2022 Nature Communications Immuno-oncology Immune HALO
In†vivo†G-CSF treatment activates the GR-SOCS1 axis to suppress IFN-? secretion by natural killer cells Zhao X, Peng T, Cao X, Hou Y, Li R, Han T, Fan Z, Zhao M, Chang Y, Chen H, Li C, Huang X 2022 Cell Reports Immunology Highplex FL HALO
Integrated multi-omics analysis of adverse cardiac remodeling and metabolic inflexibility upon ErbB2 and ERR? deficiency Dufour C, Xia H, B'chir W, Perry M, Kuzmanov U, Gainullina A, Dejgaard K, Scholtes C, Ouellet C, Zuo D, Sanguin-Gendreau V, Guluzian C, Smith H, Muller W, Audet-Walsh E, Sergushichev A, Emili A, Giguere V 2022 Communications Biology Other Multiplex IHC HALO
Phase I/II clinical trial of a helper peptide vaccine plus PD-1 blockade in PD-1 antibody-naÔve and PD-1 antibody-experienced patients with melanoma (MEL64) Vavolizza R, Petroni G, Mauldin I, Chianese-Bullock K, Olson W, Smith K, Dengel L, Haden K, Grosh W, Kaur V, Varhegyi N, Gaughan E, Slingluff C 2022 Journal for ImmunoTherapy of Cancer Immuno-oncology Highplex FL HALO
Unveiling the tumor immune microenvironment of organ-specific melanoma metastatic sites Conway J, Rawson R, Lo S, Ahmed T, Veregara I, Gide T, Attrill G, Carlino M, Saw R, Thompson J, Spillane A, Shannon K, Shivalingam B, Menzies A, Wilmott J, Long G, Scolyer R, da Silva I 2022 Journal for ImmunoTherapy of Cancer Oncology Classifier, Spatial Analysis, Highplex FL HALO
Effects of hypoxia-preconditioned HucMSCs on neovascularization and follicle survival in frozen/thawed human ovarian cortex transplanted to immunodeficient mice Cheng J, Ruan X, Li Y, Du J, Jin F, Gu M, Zhou Q, Xu X, Yang Y, Wang H, Mueck A 2022 Stem Cell Research & Therapy Other Multiplex IHC HALO
Intratumoral administration of CD1c (BDCA-1)+†and CD141 (BDCA-3)+†myeloid dendritic cells in combination with talimogene laherparepvec in immune checkpoint blockade refractory advanced melanoma patients: a phase I clinical trial Schwarze J, Tijtgat J, Awada G, Cras L, Vasaturo A, Bagnall C, Forsyth R, Dufait I, Tuyaerts S, Riet I, Neyns B 2022 Journal for ImmunoTherapy of Cancer Oncology, Immuno-oncology Highplex FL HALO
TIE2-high cervical cancer cells promote tumor angiogenesis by upregulating TIE2 and VEGFR2 in endothelial cells Tan S, Chen Y, Du S, Li W, Liu P, Zhao J, Yang P, Cai J, Gao R, Wang Z 2022 Translational Oncology Oncology Area Quantification, Highplex FL HALO
Supraphysiologic Testosterone Induces Ferroptosis and Activates Immune Pathways through Nucleophagy in Prostate Cancer Kumar R, Mendonca J, Owoyemi O, Boyapati K, Thomas N, Kanacharoen S, Coffey M, Topiwala D, Homes C, Ozbek B, Jones T, Rosen M, Dong L, Wiens S, Brennen W, Isaacs J, Marzo A, Markowski M, Antonarakis E, Qian D, Pienta K, Pardoll D, Carducci M, Denmeade S, Kachhap S 2021 Cancer Research Oncology Cytonuclear HALO
Diverse human astrocyte and microglial transcriptional responses to Alzheimerís pathology Smith A, Davey K, Tsartsalis S, Khozoie C, Fancy N, Tang S, Liaptsi E, Weinert M, McGarry A, Muirhead R, Gentleman S, Owen D, Matthews P 2021 Acta Neuropathologica Neuroscience Area Quantification, Multiplex IHC, Microglia HALO
T Cells Limit Accumulation of Aggregate Pathology Following Intrastriatal Injection of†?-Synuclein Fibrils George S, Tyson T, Rey N, Sheridan R, Peelaerts W, Becker K, Schulz E, Meyerdirk L, Burmeister A, von Linstow C, Steiner J, Galvis M, Ma J, Pospisilik J, Labrie V, Brundin L, Brundin P 2021 Journal of Parkinson's Disease Immunology, Neuroscience Microglia HALO
Viral alpha-synuclein knockdown prevents spreading synucleinopathy Menon S, Kofoed R, Nabbouh F, Xhima K, Al-Fahoum Y, Langman T, Mount H, Shihabuddin L, Sardi S, Fraser P, Watts J, Aubert I, Tandon A 2021 Brain Communication Neuroscience Highplex FL HALO
Neoadjuvant PD-1 blockade induces T cell and cDC1 activation but fails to overcome the immunosuppressive tumor associated macrophages in recurrent glioblastoma Lee A, Mochizuki A, Reynoso J, Orpilla J, Chow F, Kienzler J, Everson R, Nathanson D, Bensinger S, Liau L, Cloughesy T, Hugo W, Prins R 2021 Nature Communications Immuno-oncology Highplex FL HALO
Haploinsufficiency of the lysosomal sialidase†NEU1†results in a model of pleomorphic rhabdomyosarcoma in mice Machado E, van de Vlekkert D, Sheppard H, Perry S, Downing S, Laxton J, Ashmun R, Finkelstein D, Neale G, Hu H, Harwood F, Koo S, Grosveld G, d'Azzo A 2022 Communications Biology Oncology Membrane, Spatial Analysis HALO
STRIP2 motivates non-small cell lung cancer progression by modulating the TMBIM6 stability through IGF2BP3 dependent Zhang X, Chen Q, He Y, Shi Q, Yin C, Xie Y, Yu H, Bao Y, Tang C, Dong Z 2022 Research Square Oncology Multiplex IHC HALO
Proliferative tumor infiltrating lymphocytes abundance within microenvironment impact clinical outcome in cutaneous B-cell lymphomas Menguy S, Prochazkova-Carolotti M, Azzi-Martin L, Ferte T, Bresson-Bepoldin L, Rey C, Vergier B, Merlio J, Beylot-Barry M, Pham-Ledard A 2022 Journal of Investigative Dermatology Immuno-oncology Classifier, Highplex FL HALO
Integrated pathological analysis to develop a Gal-9 based immune survival stratification to predict the outcome of lung large cell neuroendocrine carcinoma and its usefulness in immunotherapy Che Y, Luo Z, Cao Y, Wang J, Xue Q, Sun N, He J 2022 International Journal of Biological Sciences Oncology Classifier, Multiplex IHC HALO
Artificial Intelligence–Powered Prediction of ALK Gene Rearrangement in Patients With Non–Small-Cell Lung Cancer Terada Y, Takahashi T, Hayakawa T, Ono A, Kawata T, Isaka M, Muramatsu K, Tone K, Kodama H, Imai T, Notsu A, Mori K, Ohde Y, Nakajima T, Sugino T, Takahashi T 2022 JCO Clinical Cancer Informatics Oncology HALO, HALO AI
USP14 promotes tryptophan metabolism and immune suppression by stabilizing IDO1 in colorectal cancer Shi D, Wu X, Jian Y, Wang J, Huang C, Mo S, Li Y, Li F, Zhang C, Zhang D, Zhang H, Huang H, Chen X, Wang Y, Lin C, Liu G, Song L, Liao W 2022 Nature Communications Oncology, Dermatology Cytonuclear, Highplex FL HALO, HALO AI
Single Cell RNA-Seq Identifies Immune-Related Prognostic Model and Key Signature-SPP1 in Pancreatic Ductal Adenocarcinoma Chen K, Wang Q, Liu X, Wang F, Ma Y, Zhang S, Shao Z, Yang Y, Tian X 2022 Genes Oncology Cytonuclear, Highplex FL HALO
Dapagliflozin reduces the vulnerability of rats with pulmonary arterial hypertension-induced right heart failure to ventricular arrhythmia by restoring calcium handling Wu J, Liu T, Shi S, Fan Z, Hiram R, Xiong F, Cui B, Su X, Chang R, Zhang W, Yan M, Tang Y, Huang H, Wu G, Guang C 2022 Cardiovascular Diabetology Other Multiplex IHC HALO
The SGLT2i Dapagliflozin Reduces RV Mass Independent of Changes in RV Pressure Induced by Pulmonary Artery Banding Connelly K, Wu E, Visram A, Friedberg M, Batchu S, Yeera V, Thai K, Nghiem L, Zhang Y, Kabir G, Desjardins J, Advani A, Gilbert R 2022 Cardiovascular Drugs and Therapy Other Area Quantification HALO
The NALCN channel regulates metastasis and nonmalignant cell dissemination Rahrmann E, Shorthouse D, Jassim A, Hu L, Ortiz M, Mahler-Araujo B, Vogel P, Paez-Ribes M, Fatemi A, Hannon G, Iyer R, Blundon J, Lourenco F, Kay J, Nazarian R, Hall B, Zakharenko S, Winton D, Zhu L, Gilbertson R 2022 Nature Genetics Oncology ISH/FISH, Multiplex IHC HALO
The proteomic landscape of glioblastoma recurrence reveals novel and targetable immunoregulatory drivers Tatari N, Khan S, Livingstone J, Zhai K, Mckenna D, Ignatchenko V, Chokshi C, Gwynne W, Singh M, Revill S, Mikolajewicz N, Zhu C, Chan J, Hawkins C, Lu J, Provias J, Ask K, Morrissy S, Brown S, Weiss T, Weller M, Han H, Greenspoon J, Moffat J, Venugopal C, Boutros P 2022 Acta Neuropathologica Oncology Multiplex IHC, Figure Maker, TMA HALO
Relaxin/insulin-like family peptide receptor 4 (Rxfp4) expressing hypothalamic neurons Q8 modulate food intake and preference in mice Lewis J, Woodward O, Nuzzaci D, Smith C, Adriaenssens A, Billing L, Brighton C, Phillips B, Tadross J, Kinston S, Ciabatti E, Gottgens B, Tripodi M, Mornigold D, Baker D, Gribble F, Reimann F 2022 Molecular Metabolism Metabolism ISH/FISH, Highplex FL HALO
Positron emission tomography imaging of the sodium iodide symporter senses real-time energy stress in vivo Dzien P, Mackintosh A, Malviya G, Johnson E, Soloviev D, Brown G, Uribe A, Nixon C, Lyons S, Maddocks O, Blyth K, Lewis D 2022 Research Square Metabolism Cytonuclear HALO
Regional epithelial cell diversity in the small intestine of pigs Wiarda J, Becker S, Sivasankaran S, Loving C, 2022 Journal of Animal Science Gastroenterology ISH/FISH, Figure Maker HALO
PD-L1 predicts chemotherapy resistance in large-cell neuroendocrine carcinoma Che Y, Luo Z, Cao Y, Sun N, Xue Q, He J 2022 British Journal of Surgery Oncology Classifier, Multiplex IHC HALO
The Novel Gabapentinoid Mirogabalin Prevents Upregulation of _2_-1 Subunit of Voltage-Gated Calcium Channels in Spinal Dorsal Horn in a Rat Model of Spinal Nerve Ligation Domon Y, Kobayashi N, Kubota K, Kitano Y, Ueki H, Shimojo Y, Ishikawa K, Ofune Y 2022 Drug Research Neuroscience Area Quantification HALO
Traumatic Brain Injury Leads to Alterations in Contusional Cortical miRNAs Involved in Dementia Naseer S, Abelleira-Hervas L, Savani D, de Burgh R, Aleksynas R, Donat C, Syed N, Sastre M 2022 Biomolecules Neuroscience Microglia HALO
Attenuation of relapsing fever neuroborreliosis in mice by IL-17A blockade Cheng M, Xu J, Ding K, Liu H 2022 Proceedings of the National Academy of Sciences Infectious Disease Highplex FL HALO
Single cell analysis of cribriform prostate cancer reveals cell intrinsic and tumor microenvironmental pathways of aggressive disease Wong H, Sheng Q, Hesterberg A, Croessmann S, Rios B, Giri K, Jackson J, Miranda A, Watkins E, Schaffer K, Donahue M, Winkler E, Penson D, Smith J, Herrell S, Luckenbaugh A, Barocas D, Kim Y, Graves D, Giannico G, Rathmell J, Park B, Gordetsky J, Hurley P 2022 Nature Communications Oncology ISH/FISH HALO
Fibrocytes boost tumor-supportive phenotypic switches in the lung cancer niche via the endothelin system Weigert A, Zheng X, Nenzel A, Turkowski K, Gunther S, Strack E, Sirait-Fischer E, Elwakeel E, Kur I, Nikam V, Valasarajan C, Winter H, Wissgott A, Voswinkel R, Grimminger F, Brune B, Seeger W, Pullamsetti S, Savai R 2022 Nature Communications Oncology Spatial Analysis, Highplex FL HALO
Single-cell RNA-seq transcriptomic landscape of human and mouse islets and pathological alterations of diabetes Chen K, Zhang J, Huang Y, Tian X, Yang Y, Dong A 2022 iScience Metabolism Cytonuclear, Highplex FL HALO
Overcoming high level adenosine-mediated immunosuppression by DZD2269, a potent and selective A2aR antagonist Bai Y, Zhang X, Zheng J, Liu Z, Yang Z, Zhang X 2022 Journal of Experimental & Clinical Cancer Research Oncology Multiplex IHC HALO
Functional Intercellular Transmission of miHTT via Extracellular Vesicles: An In Vitro Proof-of-Mechanism Study Morais R, Sogorb-Gonzalez M, Bar C, Timmer N, Van der Bent M, Wartel M, Valles A 2022 Cells Neuroscience Area Quantification HALO
Carbonic anhydrase 14 protects the liver against the cytotoxicity of bile acids in a biliary bicarbonate umbrella-related manner Qian J, Shen Q, Zhang T, Chen J, Chen L, Dong Y, Yan R, Chen Z 2022 Life Sciences Other Multiplex IHC HALO
Targeting breast and pancreatic cancer metastasis using a dual-cadherin antibody Micalizzi D, Che D, Nicholson B, Edd J, Desai N, Lang E, Toner M, Maheswaran S, Ting D, Haber D 2022 Proceedings of the National Academy of Sciences Oncology Multiplex IHC, Highplex FL HALO
Fucosylation of HLA-DRB1 regulates CD4+T cell-mediated anti-melanoma immunity and enhances immunotherapy efficacy Lau E, Lester D, Burton C, Gardner A, Innamarato P, Kodumudi K, Liu Q, Adhikari E, Ming Q, Williamson D, Frederick D, Sharova T, White M, Markowitz J, Cao B, Nguyen J, Johnson J, Beatty M, Mockabee0Macias A, Mercurio M, Watson G, Chen P, McCarthy S, Moran C, Messina J, Thomas K, Darville L, Izuma V, Koomen J, Pilon-Thomas S, Ruffell B, Luca V, Haltiwanger R, Wang X, Wargo J, Boland G 2022 Research Square Immuno-oncology Registration HALO
Comparative analysis of the immune response to RFA and cryoablation in a colon cancer mouse model Mauda-Havakuk M, Hawken N, Owen J, Mikhail A, Saxena A, Karim B, Wakim P, Pritchard W, Karanian J, Wood B 2022 Scientific Reports Oncology Cytonuclear HALO
Cystatin C is glucocorticoid-responsive, directs recruitment of Trem2+ macrophages and predicts failure of cancer immunotherapy Kleeman S, Demestichas B, Mourikis N, Loiero D, Ferrer M, Bankier S, Riazat-Kesh Y, Lee H, Chantzichristos D, Regan C, Preall J, Sinha S, Rosin N, Yipp B, de Almeida L, Biernaskie J, Dufour A, Tober-Lau P, Ruusalepp A, Bjorkegren J, Ralser M, Kuth F, Demechev V, Heywood T, Gao Q, Johannsson G, Koelzer V, Walker B, Meyer H, Janowitz T 2022 medRxiv Immuno-oncology Multiplex IHC HALO, HALO AI
Single-incision cochlear implantation and hearing evaluation in piglets and minipigs Yildiz E, Gerlitz M, Gadenstaetter A, Landegger L, Nieratschker M, Schum D, Schmied M, Haase A, Kanz F, Kramer A, Glueckert R, Staecker H, Honeder C, Arnoldner C 2022 Hearing Research Neuroscience Multiplex IHC HALO
Use of High-Plex Data Reveals Novel Insights into the Tumour Microenvironment of Clear Cell Renal Cell Carcinoma De Filippis R, Wolflein G, Um I, Caie P, Warren S, White A, Suen E, To E, Arandjelovic O, Harrison D 2022 Cancers Oncology Spatial Analysis HALO, HALO AI
Cholesterol-Conjugated Short-Interfering RNA Silencing Tnf for the Treatment of Liver Macrophage-Mediated Acute Inflammation in Nonalcoholic Fatty Liver Disease Craig K, Abrams M, Amiji M 2022 Nucleic Acid of Therapeutics Metabolism Area Quantification HALO
Differential expression of CCR8 in tumors versus normal tissue allows specific depletion of tumor-infiltrating T regulatory cells by GS-1811, a novel Fc-optimized anti-CCR8 antibody Weaver J, Stack E, Bugge J, Hu C, McGrath L, Mueller A, Wong M, Klebanov B, Rahman T, Kaufman R, Fregeau C, Spaulding V, Priess M, Legendre K, Jaffe S, Upadhyay D, Singh A, Xu C, Krukenberg K, Zhang Y, Ezzyat Y, Axe D, Kuhne M, Meehl M, Shaffer D, Weist B, Wiederschain D, Depis F, Gostissa M 2022 Oncoimmunology Immuno-oncology Cytonuclear HALO
Single-cell RNA sequencing reveals cellular and molecular reprograming landscape of gliomas and lung cancer brain metastases Sun H, Li L, Lao I, Li X, Xu B, Cao Y, Jin W 2022 Clinical and Translational Medicine Oncology Cytonuclear, Highplex FL HALO
Systemic Nos2 Depletion and Cox inhibition limits TNBC disease progression and alters lymphoid cell spatial orientation and density Somasundaram V, Ridnour L, Cheng R, Walke A, Kedei N, Bhattacharyya D, Wink A, Edmondson E, Butcher D, Warner A, Dorsey T, Scheiblin D, Heinz W, Bryant R, Kinders R, Lipkowitz S, Wong S, Pore M, Hewitt S, McVicar D, Anderson S, Chang J, Glynn S, Ambs S, Lockett S, Wink D 2022 Redox Biology Oncology Classifer, ISH/FISH, Spatial Analysis, Registration, ISH-IHC/FISH-IF HALO
Booster Immunization with Ad26.COV2.S or Omicron Adapted Vaccine Enhanced Immune Responses and Efficacy Against SARS-CoV-2 Omicron in Non-Human Primates Solforosi L, Costes L, Tolboom J, McMahan K, Anioke T, Hope D, Murdza T, Sciacca M, Bouffard E, Barrett J, Wu C, Hachmann N, Miller J, Yu J, He X, Jacob-Dolan C, Huber S, Dekking L, Chamanza R, Choi Y, Feddes-de Boer K, Barouch D, Schuitemaker H, Zahn R, Wegmann F 2022 Research Square Immunology, Infectious Disease HALO, HALO Link
Histopathologic differences in granulomas of Mycobacterium bovis bacille Calmette Guérin (BCG) vaccinated and non-vaccinated cattle with bovine tuberculosis Kanipe C, Boggiatto P, Putz E, Palmer M 2022 Frontiers in Microbiology Immunology, Infectious Disease Cytonuclear HALO
Deep learning-based quantification of NAFLD/NASH progression in human liver biopsies Heinemann F, Gross P, Zeveleva S, Qian H, Hill J, Hofer A, Jonigk D, Diehl A, Abdelmalek M, Lenter M, Pullen S, Guarnieri P, Stierstorfer B 2022 Scientific Reports Metabolism Area Quantification HALO, HALO AI
The Neo-PLANET phase II trial of neoadjuvant camrelizumab plus concurrent chemoradiotherapy in locally advanced adenocarcinoma of stomach or gastroesophageal junction Tang Z, Wang Y, Liu D, Wang X, Xu C, Yu Y, Cui Y, Tang C, Li Q, Sun J, Zhang Q, Ji Y, Ma G, Li H, Shen Z, Shen K, Zheng R, Hou Z, Liu T, Wang J, Sun Y 2022 Nature Communications Immuno-oncology Cytonuclear, Multiplex IHC HALO
Annexin A2/TLR2/MYD88 pathway induces arginase 1 expression in tumor-associated neutrophils Zhang H, Zhu X, Friesen T, Kwak J, Pisarenko T, Mekvanich S, Velasco M, Randolph T, Kargl J, Houghton A 2022 Journal of Clinical Investigation Immuno-oncology Spatial Analysis, ISH-IHC/FISH-IF HALO
Assessment of spatial transcriptomics for oncology discovery Lyubetskaya A, Rabe B, Fisher A, Lewin A, Neuhaus I, Brett C, Brett T, Pereira E, Golhar R, Kebede S, Font-Tello A, Mosure K, Wittenberghe N, Mavrakis K, Maclsaac K, Chen B, Drokhlyansky E 2022 Cell Reports Methods Oncology Cytonuclear, Multiplex IHC, Registration HALO, HALO AI
Spatiotemporal transcriptome analysis reveals critical roles for mechano-sensing genes at the border zone in remodeling after myocardial infarction Yamada S, Ko T, Hatsuse S, Nomura S, Zhang B, Dai Z, Inoue S, Kubota M, Sawami K, Yamada T, Sassa T, Katagiri M, Fujita K, Katoh M, Ito M, Harada M, Toko H, Takeda N, Morita H, Aburatani H, Komuro I 2022 Nature Cardiovascular Research Myology ISH-IHC/FISH-IF HALO
Dynamin-2 deficiency causes age- and sex-dependent neutropenia and myelodysplasia in mice Willis A, Corey S, Murga-Zamalloa C, Karimi S, Khaddour K, Quigley J, Eklund E, Chen Y 2022 Blood Advances Other Cytonuclear, Multiplex IHC HALO
Loss of functional System x-c uncouples aberrant postnatal neurogenesis from epileptogenesis in the hippocampus of Kcna1-KO mice Aloi M, Thompson S, Quartapella N, Noebels J 2022 Cell Reports Neuroscience ISH-IHC/FISH-IF HALO
Impacts of neoadjuvant chemoradiotherapy on the immune landscape of esophageal squamous cell carcinoma Wen J, Fang S, Hu Y, Xi M, Weng Z, Pan C, Luo K, Ling Y, Lai R, Xie X, Lin X, Lin T, Chen J, Liu Q, Fu J, Yang H 2022 EBioMedicine Immuno-oncology Cytonuclear, Highplex FL HALO
CD19 and intraglandular CD163-positivity as prognostic indicators of pregnancy outcome in CD138-negative women with a previous fresh-embryo-transfer failure Fan X, Yang Y, Wen Q, Li Y, Meng F, Liao J, Chen H, Lu G, Gong F 2021 Journal of Reproductive Immunology Other Multiplex IHC, Figure Maker HALO
A clinically applicable integrative molecular classification of meningiomas Nassiri F, Liu J, Patil V, Mamatjan Y, Wang J, Hugh-White R, Macklin A, Khan S, Singh O, Karimi S, Corona R, Liu L, Chen C, Chakravarthy A, Wei Q, Mehani B, Suppiah S, Gao A, Workewych A, Tabatabai G, Boutros P, Bader G, de Carvalho D, Kislinger T, Aldape K, Zadeh G 2021 Nature Oncology Multiplex IHC HALO
Inflammatory Pathways Are Impaired in Alzheimer Disease and Differentially Associated With Apolipoprotein E Status Kloske C, Dugan A, Weekman E, Winder Z, Patel E, Nelson P, Fardo D, Wilcock D 2021 Journal of Neuropathology & Experimental Neurology Neuroscience Object Colocalization HALO
Heterogeneity of programmed death-ligand 1 expression and infiltrating lymphocytes in paired resected primary and metastatic non-small cell lung cancer Wu J, Sun W, Yang X, Wang H, Liu X, Chi K, Zhou L, Huang X, Mao L, Zhao S, Ding T, Meng B, Lin D 2021 Modern Pathology Immuno-oncology Spatial Analysis, Highplex FL HALO
Functional expression of TRPA1 channel, TRPV1 channel and TMEM100 in human odontoblasts Liu Y, Wang Y, Lou Y, Tian W, Que K 2021 Journal of Molecular Histology Other Highplex FL HALO
Whole-slide imaging, tissue image analysis, and artificial intelligence in veterinary pathology: An updated introduction and review Zuraw A, Aeffner F 2021 Veterinary Pathology Review Spatial Analysis HALO
Recipient bone marrow-derived IL-17 receptor A-positive cells drive allograft fibrosis in a mouse intrapulmonary tracheal transplantation model Watanabe T, Juvet S, Boonstra K, Guan Z, Joe B, Teskey G, Keshavjee S, Martinu T 2021 Transplant Immunology Other Highplex FL HALO
Transcriptional and functional divergence in lateral hypothalamic glutamate neurons projecting to the lateral habenula and ventral tegmental area Rossi M, Basiri M, Liu Y, Hashikawa Y, Hashikawa K, Fenno L, Kim Y, Ramakrishnan C, Deisseroth K, Stuber G 2021 Neuron Neuroscience ISH/FISH HALO
Selective targeting of MYC mRNA by stabilized antisense oligonucleotides Gill T, Wang H, Bandaru R, Lawlor M, Lu C, Nieman L, Tao J, Zhang Y, Anderson D, Ting D, Chen X, Bradner J, Ott C 2021 Oncogene Oncology Multiplex IHC HALO
Genetic suppression of the dopamine D3 receptor in striatal D1 cells reduces the development of L-DOPA-induced dyskinesia Lanza K, Centner A, Coyle M, Del Priore I, Manfredsson F, Bishop C 2021 Experimental Neurology Neuroscience ISH/FISH HALO
Aristolochic acid I promoted clonal expansion but did not induce hepatocellular carcinoma in adult rats Liu Y, Lu H, Qi X, Xing G, Wang X, Yu P, Liu L, Yang F, Ding X, Deng Z, Gong L, Ren J 2021 Acta Pharmacologica Sinica Oncology Object Colocalization HALO
Complement activation is a crucial driver of acute kidney injury in rhabdomyolysis Broudhabhay I, Poillerat V, Grunenwald A, Torset C, Leon J, Daugan M, Lucibello F, Karoui K, Ydee A, Chauvet S, Girardie P, Sacks S, Farrar C, Garred P, Berthaud R, Le Quintrec M, Rabant M de Lonlay P, Rambaud C, Gnemmi V, Fremeaux-Bacchi V, Frimat M, Roumenina L 2021 Kidney International Other Area Quantification HALO
An endogenous opioid circuit determines state-dependent reward consumption Castro D, Oswell C, Zhang E, Pedersen C, Piantadosi S, Rossi M, Hunker A, Guglin A, Moron J, Zweifel L, Stuber G, Bruchas M 2021 Nature Neuroscience ISH/FISH HALO
Shaping the thyroid: from peninsula to de novo lumen formation Pierreux C 2021 Molecular and Cellular Endocrinology Review Highplex FL HALO
Biomimetic nanoparticles drive the mechanism understanding of shear-wave elasticity stiffness in triple negative breast cancers to predict clinical treatment Zheng D, Zhou J, Qian L, Liu X, Chang C, Tang S, Zhang H, Zhou S 2022 Bioactive Materials Oncology HALO, Pharma Services
Radiation Therapy Enhanced by NBTXR3 Nanoparticles Overcomes Anti-PD1 Resistance and Evokes Abscopal Effects Hu Y, Paris S, Barsoumian H, Abana C, He K, Wasley M, Younes A, Masrorpour F, Chen D, Yang L, Dunn J, Zhang J, Gandhi S, Nguyen Q, Cortez M, Welsh J 2021 International Journal of Oncology *Biology* Physics Immuno-oncology Multiplex IHC HALO
MAOA promotes prostate cancer cell perineural invasion through SEMA3C/PlexinA2/NRP1–cMET signaling Yin L, Li J, Wang J, Pu T, Wei J, Li Q, Wu B 2021 Oncogene Oncology Multiplex IHC HALO
Single-cell profiling of tumor-infiltrating TCF1/TCF7+ T cells reveals a T lymphocyte subset associated with tertiary lymphoid structures/organs and a superior prognosis in oral cancer Peng Y, Xiao L, Rong H, Ou Z, Cai T, Liu N, Li B, Zhang L, Wu F, Lan T, Lin X, Li Q, Ren S, Fan S, Li J 2021 Oral Oncology Oncology Spatial Analysis, Highplex FL HALO
Follicular lymphoma triggers phenotypic and functional remodeling of the human lymphoid stromal cell landscape Mourcin F, Verdiere L, Roulois D, Amin R, Lamaison C, Sibut V, Thamphya B, Pangault C, Monvoisin C, Huet S, Seffals M, Saulande S, Mechta-Grigoriou F, Legoix P, Rossille D, Guirriec M, Leonard S, Cartron G, Salles G, Fest T, Tarte K 2021 Immunity Immuno-oncology Highplex FL HALO, HALO AI
Sex differences in the rodent hippocampal opioid system following stress and oxycodone associated learning processes Chalangal J, Mazid S, Windisch K, Milner T 2021 Pharmacology Biochemistry and Behavior Review ISH/FISH HALO
Tumor-immune landscape patterns before and after chemoradiation in resectable esophageal adenocarcinomas Soeratram T, Creemers A, Meijer S, deBoer O, Vos W, Hooijer G, van Berge Henegouwen M, Hulshof M, Bergman J, Lei M, Bijlsma M, Ylstra B, van Grieken N, van Laarhoven H 2021 The Journal of Pathology Immuno-oncology Cytonuclear HALO
Porcine epidemic diarrhea virus infection induces endoplasmic reticulum stress and unfolded protein response in jejunal epithelial cells of weaned pigs Chen Y, Gabler N, Burrough E 2021 Veterinary Pathology Other Multiplex IHC HALO
The association of HHLA2 and PD-L1 expression with prognosis and immune microenvironment in hepatocellular carcinoma Wang C, Chen S, Yang X, Wu T, Liu L, Yun J 2022 Research Square Oncology Cytonuclear, Multiplex IHC HALO
Associations between quantitative measures of TDLU involution and breast tumor molecular subtypes among breast cancer cases in the Black Women’s Health Study: a case–case analysis Lynn B, Lord B, Cora R, Pfeiffer R, Lawrence S, Zirpoli G, Bethea T, Palmer J, Gierach G 2022 Breast Cancer Research Oncology HALO, HALO Link
Contribution of NADPH oxidase to the retention of UVR-induced DNA damage by arsenic Cooper K, Volk L, Dominguez D, Duran A, Liu K, Hudson L 2021 Toxicology and Applied Pharmacology Other Multiplex IHC HALO
Use of high-rate ventilation results in enhanced recellularization of bio-engineered lung scaffolds Ahmadipour M, Taniguchi D, Duchesneau P, Aoki F, Phillips G, Sinderby C, Waddell T, Karoubi G 2021 Tissue Engineering Part C: Methods Biomaterials Classifier, Multiplex IHC HALO
Splenic T lymphocytes induce the formation of immunosuppressive neutrophils through IFN-_ in sepsis Huang J, Sun R, Yang Y, Li L, Liu L, Shao Y, Ji D, Sun B 2021 Inflammation Research Immunology Highplex FL HALO
Multiparameter immunohistochemistry analysis of HIV DNA, RNA and immune checkpoints in lymph node tissue Richardson Z, Deleage C, Tutuka C, Walkiewica M, Del Rio-Estrada P, Pascoe R, Evans V, Reyesteran G, Gonzales M, Roberts-Thomson S, Gonzalez-Navarro M, Torres-Ruiz, F, Estes J, Lewin S, Cameron P 2021 Journal of Immunological Methods Infectious Disease ISH-IHC/FISH-IF HALO
Distinct characteristics of limbic-predominant age-related TDP-43 encephalopathy in Lewy body disease Uemura M, Robinson J, Cousins K, Tropea T, Kargilis D, McBride J, Suh E, Xie S, Xu Y, Porta S, Uemura N, Van Deerlin V, Wolk D, Irwin D, Brunden K, Lee V, Lee E, Trojanowski J 2021 Acta Neuropathologica Neuroscience Multiplex IHC, Highplex FL HALO
Advanced glycation end-products (AGEs) are lower in prostate tumor tissue and inversely related to proportion of West African ancestry Zenner M, Helou Y, Deaton R, Sverdlov M, Wang H, Kajdacsy-Balla A, Macias V, Voisine C, Murray M, Abdulkardir S, Murphy A, Nonn L 2021 The Prostate Oncology Classifier, Area Quantification HALO
The MK2/Hsp27 axis is a major survival mechanism for pancreatic ductal adenocarcinoma under genotoxic stress Grierson P, Dodhiawala P, Cheng Y, Chen T, Khawar I, Wei Q, Zhang D, Li L, Herndon J, Monahan J, Ruzinova M, Lim K 2021 Science Translational Medicine Oncology Area Quantification, TMA HALO
Engineering Cancer Antigen-Specific T Cells to Overcome the Immunosuppressive Effects of TGF-_ Silk J, Abbott R Adams K, Bennett A, Brett S, Cornforth T, Crossland K, Figueroa D, Jing J, O'Conner C, Pachnio A, Patasic L, Peredo C, Quattrini A, Quinn L, Rust A, Saini M, Sanderson J, Steiner D, Tavano B, Viswanathan P, Wiedermann G, Wong R, Jakobsen B, Britten C, Gerry A, Brewer J 2021 The Journal of Immunology Immuno-oncology, other ISH/FISH HALO
Tailoring Chemoimmunostimulant Bioscaffolds for Inhibiting Tumor Growth and Metastasis after Incomplete Microwave Ablation Shen Y, Chen L, Guan X, Han X, Bo X, Li S, Sun L, Chen Y, Yue W, Xu H 2021 ACS Nano Highplex FL HALO
Identifying the Ideal Target Vessel Size for Bariatric Embolization: Histologic Analysis of Swine and Human Gastric Fundi Vairavamurthy J, Yuan F, Anders R, Kraitchman D, Weiss C 2022 Journal of Vascular and Interventional Radiology Other HALO
Conditional deletion of mTOR discloses its essential role in early B-cell development Zhang S, Dubois W, Feng X, Nguyen J, Young N, Mock B 2021 Molecular Carcinogenesis Oncology, Immunology Area Quantification HALO, HALO Link
A single-cell atlas of mouse lung development Negretti N, Plosa E, Benjamin J, Schuler B, Habermann A, Jetter C, Gulleman P, Bunn C, Hackett A, Ransom M, Taylor C, Nichols D, Matlock B, Guttentag S, Blackwell T, Banovich N, Kropski J, Sucre J 2021 Development Other ISH/FISH HALO
Method To Visualize the Intratumor Distribution and Impact of Gemcitabine in Pancreatic Ductal Adenocarcinoma by Multimodal Imaging Strittmatter N, Richards F, Race A, Ling S, Sutton D, Nilsson A, Wallez Y, Barnes J, Maglennon G, Gopinathan A, Brais R, Wong E, Serra M, Atkinson J, Smith A, Wilson J, Hamm G, Johnson T, Dunlop C, Kaistha B, Bunch J, Sansom O, Takats Z, Andren P, Lau A, Barry S, Goodwin R, Jodrell D 2022 Analytical Chemistry Oncology Classifier, Highplex FL HALO, HALO AI
Visualization of calcium channel blockers in human adrenal tissues and their possible effects on steroidogenesis in the patients with primary aldosteronism (PA) Motomura N, Yamazaki Y, Gao X, Tezuka Y, Omata K, Ono Y, Morimoto R, Satoh F, Nakamura Y, Shim J, Choi M, Ito A, Sasano H 2022 The Journal of Steroid Biochemistry and Molecular Biology Metabolism Cytonuclear HALO
Glutaminase 2 Knockdown Reduces Hyperammonemia and Associated Lethality of Urea Cycle Disorder Mouse Model Mao X, Chen H, Lin A, Kim S, Burczynski M, Na E, Halasz G, Sleeman M, Murphy A, Okamoto H, Cheng X 2022 Journal of Inherited Metabolic Disease Metabolism Area Quantification, ISH/FISH HALO
Xiaoyaosan ethyl acetate fraction alleviates depression-like behaviors in CUMS mice by promoting hippocampal neurogenesis via modulating the IGF-1R_/PI3K/Akt signaling pathway Zeng J, Ji Y, Luan F, Hu J, Rui Y, Liu Y, Rao Z, Liu R, Zeng N 2022 Journal of Experimental & Clinical Cancer Research Neuroscience Highplex FL HALO
What Happens to the Preserved Renal Parenchyma After Clamped Partial Nephrectomy? Xiong L, Nguyen J, Peng Y, Zhou Z, Ning K, Jia N, Nie J, Wen D, Wu Z, Roversi G, Palacios D, Abramczyk E, Munoz-Lopez C, Campbell J, Cao Y, Li Wencai, Zhang X, He Z, Li X, Huang J, Shou J, Wu J, Chen M, Chen X, Zheng J, Xu C, Zhong W, Li Z, Dong W, Zhou J, Zhang H, Luo J, Liu J, Sun G, Han H, Guo S, Dong P, Zhou F, Yu C, Campbell S, Zhang Z 2022 European Urology Other Area Quantification, ISH/FISH HALO
SIGLEC15 amplifies immunosuppressive properties of tumor-associated macrophages in pancreatic cancer Li, T, Jin K, Li H, Ye L, Li P, Jiang B, Lin X, Liao Z, Zhang H, Shi S, Lin M, Fei Q, Xiao Z, Xu H, Liu L, Yu X, Wu W 2022 Cancer Letters Immuno-oncology Highplex FL, TMA HALO
Presence of Tim3+ and PD-1+ CD8+ T cells identifies microsatellite stable colorectal carcinomas with immune exhaustion and distinct clinicopathological features Klapholz M, Drage M, Srivastava A, Anderson A 2022 The Journal of Pathology Oncology Multiplex IHC, Highplex FL HALO
Defects in NLRP6, autophagy and goblet cell homeostasis are associated with reduced duodenal CRH receptor 2 expression in patients with functional dyspepsia Bruce J, Burns G, Soh W, Nair P Sherwin S, Fan K, Dowling L, Goggins B, Koloski N, Potter M, Bollipo S, Foster R, Gan L, Veysey M, Philpott D, Girardin S, Holtmann G, Kaiko G, Walker M, Talley N, Keely S 2022 Brain, Behavior, and Immunity Metabolism Area Quantification HALO
Pharmacological HIF-1 stabilization promotes intestinal epithelial healing through regulation of _-integrin expression and function Goggins B, Minihan K, Sherwin S, Soh W, Pryor J, Bruce J, Liu G, Mathe A, Knight D, Horvat J, Walker M, Keely S 2021 American Journal of Physiology-Gastrointestinal and Liver Physiology Gastroenterology Area Quantification HALO
Ex vivo enzymatic treatment converts blood type A donor lungs into universal blood type lungs Wang A, Ribeiro R, Ali A, Brambate E, Abdelnour-Berchtold E, Michaelsen V, Zhang Y, Rahfeld P, Moon H, Gokhale H, Gazzalle A, Pal P, Liu M, Waddell T, Cserti-Gadewich C, Tinckam K, Kizhakkedathu J, West L, Keshavjee S, Withers S, Cypel M 2022 Science Translational Medicine Other Area Quantification, Cytonuclear HALO
Evaluating changes in GABAergic and glutamatergic pathways in early life following prenatal stress and postnatal neurosteroid supplementation Crombie G, Palliser H, Shaw J, Hodgson D, Walkder D, Hirst J 2022 Psychoneuroendocrinology Neuroscience Multiplex IHC HALO
Impact of HPV status on immune responses in head and neck squamous cell carcinoma Qureshi H, Zhu X, Yang G, Steadele M, Pierce R, Futran N, Lee S, Mendez E, Houghton A 2022 Oral Oncology Oncology Multiplex IHC, Spatial Analysis, Highplex FL HALO
Murine fecal microbiota transfer models selectively colonize human microbes and reveal transcriptional programs associated with response to neoadjuvant checkpoint inhibitors Shaikh F, Gills J, Mohammad F, White J, Stevens C, Ding H, Fu J, Tam A, Blosser R, Domingue J, Larman T, Chaft J, Spicer J, Reuss J, Naidoo J, Forde P, Ganguly S, Housseau F, Pardoll D, Sears C 2022 Cancer Immunology, Immunotherapy Immuno-oncology Multiplex IHC HALO
Adolescent intermittent ethanol exposure produces Sex-Specific changes in BBB Permeability: A potential role for VEGFA Vore A, Barney T, Deak M, Varlinskaya E, Deak T 2022 Brain, Behavior, and Immunity Neuroscience ISH/FISH HALO
T-cell mediated targeted delivery of anti-PD-L1 nanobody overcomes poor antibody penetration and improves PD-L1 blocking at the tumor site Pierre-Florent P, Bombart R, Desimpel P, Naulaerts S, Thouvenel L, Collet J, Van den Eynde B, Zhu J 2022 Cancer Immunology Research Immuno-oncology Area Quantification, Cytonuclear HALO
Association between mitochondrial and nuclear DNA damages and cellular senescence in the patients with biliary atresia undergoing Kasai portoenterostomy and liver transplantation Nakajima Y, Yamazaki Y, Gao X, Hashimoto M, Nio M, Wada M, Fujishima F, Sasano H 2022 Medical Molecular Morphology Gastroenterology Multiplex IHC HALO
Crocin alleviates cognitive impairment associated with atherosclerosis via improving neuroinflammation in LDLR_/_ mice fed a high-fat/cholesterol diet Song R, Han S, Gao H, Jiang H, Li X 2022 Phytotherapy Research Neuroscience Area Quantification HALO
Developing a Nomogram for Preoperative Prediction of Cervical Cancer Lymph Node Metastasis by Multiplex Immunofluorescence Wu J, Guo Q, Zhu J, Wu Y, Liang S Chen S, Wang S, Ju X, Wu X 2022 Authorea Oncology Spatial Analysis, Highplex FL, TMA HALO
Bone quality and composition are influenced by egg production, layer line, and estradiol-17ß in laying hens Eusemann B, Ulrich R, Sacnhez-Rodriquez E, Benavides-Reyes C, Dominguez-Gasca, Rodriguez-Navarro A, Petow S 2022 Avian Pathology Other Classifier, Multiplex IHC HALO
PERK reprograms hematopoietic progenitor cells to direct tumor-promoting myelopoiesis in the spleen Liu M, Wu C, Luo S, Hua Q, Chen H, Weng Y, Xu J, Lin H, Wang L, Li J, Zhu L, Guo Z, Zhuang S, Kang T, Zheng L 2022 Journal of Experimental Medicine Oncology Highplex FL, Registration HALO
Activation of Drp1 promotes fatty acids-induced metabolic reprograming to potentiate Wnt signaling in colon cancer Xiong X, Hasani S, Young L, Rivas D, Skaggs A, Martinez R, Wang C, Weiss H, Gentry M, Sun R, Gao T 2022 Cell Death & Differentiation Oncology Multiplex IHC HALO
Reverse Transcriptase Inhibition Disrupts Repeat Element Life Cycle in Colorectal Cancer Rajurkar M, Parikh A, Solovyov A, You E, Kulkarni A, Chu C, Xu K, Jaicks C, Taylor M, Wu C, Alexander K, Good C, Szabolcs A, Gerstberger S, Tran A, Xu N, Ebright R, Van Seventer E, Vo K, Tai E, Lu C, Joseph-Chazan J, Raabe M, Nieman L, Desai N, Arora K, Ligorio M, Thapar V, Cohen L, Garden P, Senussi Y, Zheng H, Allen J, Blaszkowsky L, Clark J, Goyal L, Wo J, Ryan D, Cocoran R, Deshpande V, Rivera M, Aryee M, Hong T, Berger S, WAlt D, Burns K, Park P, Greenbaum B, Ting D 2022 Cancer Discovery Oncology Area Quantification, Multiplex IHC HALO
Tissue-resident FOLR2+ macrophages associate with CD8+ T cell infiltration in human breast cancer Ramos R, Missolo-Koussou Y, Gerber-Ferder Y, Bromley C, Bugatti M, Nunez N, Boari J, Richer W, Menger L, Denizeau J, Sedlik C, Caudana P, Kotsias F, Niborski L, Viel S, Bohec M, Lameiras S, Baulande S, Lesage L, Nicolas A, Meseure D, Vincent-Salomon A, Reyal F, Dutertre C, Ginhoux F, Vimeux L, Donnadieu E, Buttard B, Galon J, Zelenay S, Vermi W, Guermonprez P, Piaggio E, Helft J 2022 Cell Immuno-oncology Classifier, Spatial Analysis, Highplex FL HALO
Inflammatory Monocytes Promote Granuloma-Mediated Control of Persistent Salmonella Infection Bettke J, Tam J, Montoya V, Butler B, vander Velden A 2022 Infection and Immunity Infectious Disease Classifier, Area Quantification HALO
A Phase 1/2 Trial Combining Avelumab and Trabectedin for Advanced Liposarcoma and Leiomyosarcoma Wagner M, Zhang Y, Cranmer L, Loggers E, Black G, McDonnell S, Maxwell S, Johnson R, Moore R, Hermida de Viveriros P, Aicher L, Smythe K, He Q, Jones R, Pollack S 2022 Clinical Cancer Research Oncology Highplex FL HALO
Atypical chemokine receptor 3 induces colorectal tumorigenesis in mice by promoting _-arrestin-NOLC1-fibrillarin-dependent rRNA biogenesis Yang J, Miao R, Li Y, Pan T, Wu S, Qu X, Cui S 2022 Acta Pharmacologica Sinica Oncology Area Quantification HALO
Anatomic and functional mapping of human uterine innervation Pinsard M, Mouchet N, Dion L, Bessede T, Bertrand M, Darai E, Bellaud P, Loget P, Mazaud-Guittot S, Morandi X, Leveque J, Lavoue V, Duraes M, Timoh K 2022 Fertility and Sterility Other Highplex FL HALO
Cytotoxic granzyme C–expressing ILC1s contribute to antitumor immunity and neonatal autoimmunity Nixon B, Chou C, Krishna C, Dadi S, Michel A, Cornish A, Kansler E, Do M, Wang X, Capistrano K, Rudensky A, Leslie C, Li M 2022 Science Immunology Immuno-oncology Area Quantification HALO
The FUS::DDIT3 fusion oncoprotein inhibits BAF complex targeting and activity in myxoid liposarcoma Zullow H, Sankar A, Ingram D, Guerra D, D'Avino A, Collings C, Lazcano R, Wang W, Liang Y, Qi J, Lazar A, Kadoch C 2022 Molecular Cell Oncology Multiplex IHC HALO
Neoantigen-specific CD4+ T cells in human melanoma have diverse differentiation states and correlate with CD8+ T cell, macrophage, and B cell function Veatch J, Lee S, Shasha C, Singhi N, Szeto J, Moshiri A, Kim T, Smythe K, Kong P, Fitzgibbon M, Jesernig B, Bhatia S, Tykodi S, Hall E, Byrd D, Thompson J, Pillarisetty V, Duhen T, Houghton A, Newell E, Gottardo R, Riddell S 2022 Cancer Cell Immuno-oncology Spatial Analysis, Highplex FL HALO
Unchecked oxidative stress in skeletal muscle prevents outgrowth of disseminated tumour cells Crist S, Nemkov T, Dumpit R, Dai J, Tapscott S, True L, Swarbrick A, Sullivan L, Nelson P, Hansen K, Ghajar C 2022 Nature Cell Biology Myology Multiplex IHC, Registration HALO
In vitro cell cultures of Brunner's glands from male mouse to study GLP-1 receptor function Voetmann L, Underwood C, Rolin B, Hansen A, Kirk R, Pyke C, Knudsen L, Frederiksen K 2022 Methods in Cell Physiology Gastroenterology Multiplex IHC HALO
Phenotype-genotype correlation in aldosterone-producing adenomas characterized by intracellular cholesterol metabolism Harashima S, Yamazaki Y, Motomura N, Ono Y, Omata K, Tezuka Y, Morimoto R, Nakamura Y, Satoh F, Suzuki H, Kwon G, Choi M, Sasano H 2022 The Journal of Steroid Biochemistry and Molecular Biology Oncology, Metabolism Area Quantification, Membrane HALO
Reduced SARS-CoV-2 disease outcomes in Syrian hamsters receiving immune sera: Quantitative image analysis in pathologic assessments Pieda-Mora C, Robinson S, Tostanoski L, Dayao D, Chandrashekar A, Bauer K, Wrijil L, Ducat S, Hayes T, Yu J, Bondzie E, McMahan K, Sellers D, Giffin V, Hope D, Nampanya F, Mercado N, Kar S, Andersen H, Tzipori S, Barouch D, Martinot A 2022 Veterinary Pathology Infectious Disease, Other Classifier, Multiplex IHC HALO
Circulating C-Peptide Levels in Living Children and Young People and Pancreatic Beta Cell Loss in Pancreas Donors Across Type 1 Diabetes Disease Duration Carr A, Inshaw J, Flaxman C, Leete P, Wyatt R, Russell L, Palmer M, Prasolov D, Worthington T, Hull B, Wicker L, Dunber D, Oram R, Morgan N, Toss J, Richardson S, Besser 2022 Diabetes Metabolism HALO
Epithelial-to-mesenchymal transition promotes immune escape by inducing CD70 in non-small cell lung cancer Ortiz-Cuaran S, Swalduz A, Foy J, Marteau S, Morel A, Fauvet F, De Souza G, Michon L, Boussageon M, Gadot N, Godefroy M, Leon S, Tortereau A, Mourksi N, Leonce C, Albraret M, Dongre A, Vanbervliet B, Robert M, Tonon L, Pommier R, Hofman V, Attignon V, Boyault S, Audoynaud C, Auclair J, Boquet F, Wang Q, Menetrier-Caux C, Perol M, Caux C, Hofman P, Lantuejoul S, Puisieux A, Saintgny P 2022 European Journal of Cancer Oncology Cytonuclear HALO
A molecular analysis of neural olfactory placode differentiation in human pluripotent stem cells Bricker R, Bhaskar U, Titone R, Carless M, Barberi T 2022 Stem Cells and Development Other Highplex FL, Figure Maker HALO
Aberrant inflammation in rat pregnancy leads to cardiometabolic alterations in their offspring and intrauterine growth restriction in the F2 generation Ushida T, Cotechini T, Protopapas N, Atallah A, Collyer C, Toews A, Maconald-Goodfellow S, Tse M, Winn L, Pang S, Adams M, Othman M, Kotani T, Kajiyama H, Graham C 2022 Journal of Developmental Origins of Health and Disease Metabolism, Other Multiplex IHC HALO
PHGDH heterogeneity potentiates cancer cell dissemination and metastasis Rossi M, Altea-Manzano P, Demicco M, Doglioni G, Bornes L, Fukano M, Vandekeere A, Cuadros A, Fernandez-Garcia J, Riera-Domingo C, Jauset C, Planque M, Alkan H, Nittner D, Zuo D, Broadfield L, Parik S, Pane A, Rizzollo F, Rinaldi G, Zhang T, Teoh S, Aurora A, Karras P, Vermeire I, Broekaert D, Van Elsen J, Knott M, Orth M, Demeyer S, Eelen G, Dobrolecki L, Bassez A BRussel T, Sotlar K, Lewis M, Bartsch H, Wuhrer M, van Veelen P, Carmeliet J, Cools J, Morrison S, Marine J, Lambrechts D, Mazzone M, Hannon G, Lunt S, Grunewald T, Park M, van Rheenen J, Fendt S 2022 Nature Oncology Highplex FL HALO
Relationship between impaired BMP signalling and clinical risk factors at early-stage vascular injury in the preterm infant Heydarian M, Oak P, Zhang X, Kamgari N, Kindt A, Koschlig M, Pritzke T, Gonzalez-Rodriguez E, Forster K, Morty R, Hafner F, Hubener C, Flemmer A, Yildirim A, Sudheendra D, Tian X, Petrera A, Kirsten H, Ahnert P, Morrell N, Desai T, Sucre J, Spiekerkoetter E, Hilgendorff A 2022 Thorax Other ISH/FISH HALO
Potentiating adoptive cell therapy using synthetic IL-9 receptors Kalbasi A, Siurala M, Su L, Tariveranmoshabad M, Picton L, Ravikumar P, Li P, Lin J, Escuin-Ordinas H, Da T, Kremer S, Sun A, Castelli S, Agarwal S, Scholler J, Song D, Rommel P, Radaelli E, Young R, Leonard W, Ribas A, June C, Gargia K 2022 Nature Immuno-oncology Highplex FL HALO
The potassium channel auxiliary subunit Kv_2 (Kcnab2) regulates Kv1 channels and dopamine neuron firing Yee J, Rastani A, Soden M 2022 Journal of Neurophysiology Neuroscience ISH-IHC/FISH-IF HALO
The Multi-Kinase Inhibitor Lucitanib Enhances the Antitumor Activity of Coinhibitory and Costimulatory Immune Pathway Modulators in Syngeneic Models Robillard L, Liao M, Nguyen M, Harding T, Simmons A, Dusek R 2022 Journal of Immunotherapy Immuno-oncology Cytonuclear HALO
High-strength biodegradable zinc alloy implants with antibacterial and osteogenic properties for the treatment of MRSA-induced rat osteomyelitis Jia B, Zhang Z, Zhuang Y, Yang H, Han Y, Wu Q, Jia X, Yin Y, Qu X, Zheng Y, Dai K 2022 Biomaterials Biomaterials Multiplex IHC HALO
Tumor cells modulate macrophage phenotype in a novel in vitro co-culture model of the non-small cell lung cancer tumor microenvironment Park J, Chandra R, Cai L, Ganguly D, Li H, Toombs J, Girard L, Brekken R, Minna J 2022 Journal of Thoracic Oncology Immuno-oncology Highplex FL HALO
AKR1C3 regulated by NRF2/MAFG complex promotes proliferation via stabilizing PARP1 in hepatocellular carcinoma Pan D, Yang W, Zeng Y, Qin H, Xu Y, Gui Y, Fan X, Tian G, Wu Y, Sun H, Ye Y, Yang S, Zhou J, Guo Q, Zhao L 2022 Oncogene Oncology Area Quantification, TMA HALO
A Targetable Myeloid Inflammatory State Governs Disease Recurrence in Clear Cell Renal Cell Carcinoma Rappold P, Vuong L, Leibold J, Chakiryan N, Curry M, Kuo F, Sabio E, Jiang H, Nixon B, Liu M, Berglund A, Silagy A, Mascareno A, Golkaram M, Marker M, Reising A, Savchenko A, Milholland J, Chen Y, Russo P, Coleman J, Reznik E, Manley B, Ostrovnaya I, Makarav V, DiNatale R, Blum K, Ma X, Chowell D, Li M, Solit D, Lowe S, Chan T, Motzer R, Voss M, Hakimi A 2022 Cancer Discovery Oncology Highplex FL HALO
Spatiotemporal expression pattern of Progesterone Receptor Component (PGRMC) 1 in endometrium from patients with or without endometriosis or adenomyosis Thieffry C, Van Wynendaele M, Samain L, Tyteca D, Pierreux C, Marbaix E, Henriet P 2022 The Journal of Steroid Biochemistry and Molecular Biology Other ISH/FISH, Highplex FL HALO, HALO AI
Quantitative Imaging Analysis of the Spatial Relationship between Antiretrovirals, Reverse Transcriptase Simian-Human Immunodeficiency Virus RNA, and Fibrosis in the Spleens of Nonhuman Primates Devanathan A, White N, Desyaterik Y, De la Cruz G, Nekorchuk M, Terry M, Busman-Sahay K, Adamson L, Luciw P, Fedoriw Y, Estes J, Rosen E, Kashuba A 2022 Antimicrobial Agents and Chemotherapy Infectious Disease ISH/FISH HALO
Neoadjuvant Therapy Induces a Potent Immune Response to Sarcoma, Dominated by Myeloid and B Cells Goff P, Riolobos L, LaFleur B, Spraker M, Seo Y, Smythe K, Campbell J, Pierce R, Zhang Y, He Q, Kim E, Schaub S, Kane G, Mantilla J, Chen E, Ricciotti R, Thompson M, Cranmer L, Wagner M, Loggers E, Jones R, Murphy E, Blumenschein W, McClanahan T, Earls J, Flanagan K, LaFranzo N, Kim T, Pollack S 2022 Clinical Cancer Research Immuno-oncology Highplex FL HALO
NP-ALT, a Liposomal:Peptide Drug, Blocks p27Kip1 Phosphorylation to Induce Oxidative Stress, Necroptosis, and Regression in Therapy-Resistant Breast Cancer Cells Jilishitz I, Quinones J, Patel P, Chen G, Pasetsky J, VanInwegen A, Schoninger S, Jogalekar M, Tsiperson V, Yan L, Wu Y, Gottesman S, Somma J, Blain S 2021 Molecular Cancer Research Oncology Multiplex IHC HALO
Escherichia coli-specific CXCL13-producing TFH are associated with clinical efficacy of neoadjuvant PD-1 blockade against muscle-invasive bladder cancer Goubet A, Lordello L, Silva C, Peguillet I, Gazzano M, Mbogning-Fonkou M, Thelemaque C, Lebacle C, Thibault C, Audenet F, Pignot G, Gravis G, Helissey C, Campbedel L, Roupret M, Xylinas E, Ouzaid I, Dubuisson A, Mazzenga M, Flament C, Ly P, Marty V, Signolle N, Sauvat A, Sbarrato T, Filahi M, Davin C, Haddad G, Khalil J, Bleriot C, Danlos F, Dunsmore G, Mulder K, Silvin A, Raoult T, Archambaud B, Belhechmi S, Boneca I, Cayet N, Moya-Nilges M, Mallet A, Daillere R, Rouleau E, Radulescu C, Allory Y, Fieschi J, Rouanne M, Ginhoux F, Le Teuff G, Derosa L, Marabelle A, Van Dorp J, Van Dijk N, van der Heijden M, Besse B, Andre F, Merad M, Kroemer G, Scoazec J, Zitvogel L, Loriot Y 2022 Cancer Discovery Oncology Multiplex IHC, Spatial Analysis HALO
CD123-directed allogeneic chimeric-antigen receptor T-cell therapy (CAR-T) in blastic plasmacytoid dendritic cell neoplasm (BPDCN): Clinicopathological insights Pemmaraju N, Wilson N, Senapati J, Economides M, Guzman M, Neelapu S, Kazemimood R, Davis R, Jain N, Khoury J, Sugita M, Cai T, Smith J, Frattini M, Garton A, Roboz G, Konopleva M 2022 Leukemia Research Immuno-oncology ISH/FISH HALO
Integrative Analysis of Bioinformatics and Machine Learning Algorithms Identifies a Novel Diagnostic Model Based on Costimulatory Molecule for Predicting Immune Microenvironment Status in Lung Adenocarcinoma Zhai W, Duan F, Wang Y, Wang J, Zhao Z, Lin Y, Rao B, Chen S, Zheng L, Long H 2022 The American Journal of Pathology Oncology Classifier, Multiplex IHC HALO
Targeted RNA editing in brainstem alleviates respiratory dysfunction in a mouse model of Rett syndrome Sinnamon J, Jacobson M, Yung J, Mandel G 2022 Proceedings of the National Academy of Sciences Neuroscience Highplex FL HALO
Characterization of anti-CD79b/CD3 bispecific antibody, a potential therapy for B cell malignancies Wang J, Li C, He K, Kuang Z, Lu J, Yao Y, He F, Li N, Li L, Fu F, Wu Z, Zhou S, Kang D, Qiu X, Wu M, Liu Y, Cao X, Xu M, Chen B, Wu W, Guo F 2022 Cancer Immunology, Immunotherapy Immuno-oncology Highplex FL HALO
Autophagy-mediated NCOR1 degradation is required for brown fat maturation and thermogenesis Sabate-Perez A, Romero M, Sanchez-Fernandez-de-Landa P, Carobbio S, Mouratidis M, Sala D, Engel P, Villena J, Virtue S, Vidal-Puig A, Palacin M, Testar X, Zorzano A 2022 Autophagy Metabolism Highplex FL HALO, HALO AI
Co-existing alterations of MHC class I antigen presentation and IFN_ signaling mediate acquired resistance of melanoma to post-PD-1 immunotherapy Nielson M, Presti M, Sztupinszki Z, Jensen A, Draghi A, Chamberlain C, Schina A, Yde C, Wojcik J, Szallasi Z, Crowther M, Svane I, Donia M 2022 Cancer Immunology Research Immuno-oncology HALO, HALO Link
Localization of macrophage subtypes and neutrophils in the prostate tumor microenvironment and their association with prostate cancer racial disparities Maynard J, Godwin T, Lu J, Vidal I, Lotan T, De Marzo A, Joshu C, Sfanos K 2022 The Prostate Oncology ISH/FISH, Multiplex IHC HALO
Epigallocatechin-3-gallate reduces neutrophil extracellular trap formation and tissue injury in severe acute pancreatitis Li H, Qiao C, Zhao L, Jing Q, Xue D, Zhang Y 2022 Journal of Leukocyte Biology Immunology Highplex FL HALO
Notch signaling promotes mature T-cell lymphomagenesis Gao X, Wang C, Abdelrahman S, Kady N, Murga-Zamalloa C, Gann P, Sverdlov M, Wolfe A, Polk A, Brown N, Bailey N, Inamdar K, Casavilca-Zambrano S, Montes J, Barrionuevo C, Taxa L, Reneau J, Siebel C, Maillard I, Wilcox R 2022 Cancer Research Immuno-oncology Highplex FL HALO, HALO AI
Molecular identification of spatially distinct anabolic responses to mechanical loading in murine cortical bone Chlebek C, Moore J, Ross F, van der Meulen M 2022 Journal of Bone and Mineral Research Other ISH/FISH HALO
Upfront FOLFOXIRI plus bevacizumab with or without atezolizumab in the treatment of patients with metastatic colorectal cancer (AtezoTRIBE): a multicentre, open-label, randomised, controlled, phase 2 trial Antoniotti C, Rossini D, Pietrantonio F, Catteau A, Salvatore L, Lonardi S, Boquet I, Tamberi S, Marmorino F, Moretto R, Ambrosini M, Tamburini E, Tortora G, Passardi A, Bergamo F, Kassambara A, Sbarrato T, Morano F, Ritorto G, Borelli B, Boccaccino A, Conca V, Giordano M, Ugolini C, Fieschi J, Papadopulos A, Massoue C, Aprile G, Antonyzzo L, Gelsomino F, Martinelli E, Pella N, Masi G, Fontanini G, Boni L, Galon J, Cremolini C 2022 The Lancet Oncology Oncology Multiplex IHC, Spatial Analysis HALO
Plasma CD27, a surrogate of the intratumoral CD27-CD70 interaction, correlates with immunotherapy resistance in renal cell carcinoma Benhamouda N, Sam I, Epaillard N, Gey A, Phan L, Pham H, Gruel N, Saldmann A, Pineau J, Hasan M, Quiniou V, Nevoret C, Verkarre V, Libri V, Mella S, Granier C, Broudin C, Ravel P, De Guillebon E, Mauge L, Helley D, Jabla B, Chaput N, Albiges L, Katsahian S, Adam J, Mejean A, Adotevi O, Vano Y, Oudard S, Tartour E 2022 Clinical Cancer Research Oncology Spatial Analysis, Highplex FL HALO
NKG2A and HLA-E define an alternative immune checkpoint axis in bladder cancer Salome B, Sfakianos J, Ranti D, Daza J, Bieber C, Charap A, Hammer C, Banchereau R, Farkas A, Ruan D, Izadmehr S, Geanon D, Kelly G, Real R, Lee B, Beaumont K, Shroff S, Wang Y, Wang Y, Thin T, Garcia-Barros M, Hegewisch-Solloa E, Mace E, Wang L, O'Donnell T, Chowell D, Fernandez-Rodriguez R, Skobe M, Taylor N, Kim-Schulze S, Sebra R, Palmer D, Clancy-Thompson E, Hammond S, Kamphorst A, Malmberg K, Marcenaro E, Romero P, Brody R, Viard M, Yuki Y, Martin M, Carrington M, Mehrazin R, Wilund P, Mellman I, Mariathasan S, Zhu J, Galsky M, Bhardwaj N, Horowitz A 2022 Cancer Cell Oncology, Immuno-oncology Classifier, Multiplex IHC HALO, HALO AI
Human Intestinal Myofibroblasts DepositED COLLAGEN VI EnhanceS Adhesiveness for T cells - A Novel Mechanism for Maintenance of Intestinal Inflammation. Lin S, Musso A, Wang J, Mukherjee P, West G, Mao R, Lyu R, Li J, Zhao S, Elias M, Haberman Y, Denson L, Kugathasan S, Chen M, Czarnecki D, Dejanovic D, Le H, Chandra J, Lipman J, Steele S, Nguyen Q, Fiocchi C, Rieder F 2022 Matrix Biology Immunology, Other Area Quantification HALO
Impact of Physiologically Relevant Genistein Exposure at Different Time Windows on Puberty Onset and Neuroendocrine Function in Female Rats Xiong J, Tian Y, Ma G, Wang X, Shan S, Cheng G 2022 Molecular Nutrition & Food Research Other Area Quantification HALO
Periostin- and podoplanin- positive cancer-associated fibroblast subtypes cooperate to shape the inflamed tumor microenvironment in aggressive pancreatic adenocarcinoma Neuzillet C, Nicolle R, Raffenne J, Tijeras-Raballand A, Brunel A, Astorgues-Xerri L, Vacher S, Arbateraz F, Fanjul M, Hilmi M, Samain R, Klein C, Perraud A, Rebours V, Mathonnet M, Bieche I, Kocher H, Cros J, Bousquet C 2022 Journal of Pathology Oncology Area Quantification HALO
Sex-specific effects of ethanol consumption in older Fischer 344 rats on microglial dynamics and A_(1-42) accumulation Marsland P, Vore A, DaPrano E, Paluch J, Blackwell A, Varlinskaya E, Deak T 2022 Alcohol Neuroscience ISH/FISH HALO
Ablation of the endoplasmic reticulum stress kinase PERK induces paraptosis and type I interferon to promote anti-tumor T cell responses Mandula J, Chang S, Mohamed E, Jimenez R, Sierra-Mondragon R, Chang D, Obermayer A, Moran-Segura C, Das S, Vazquez-Martinez J, Prieto K, Chen A, Smalley K, Czerniecki B, Forsyth P, Koya R, Ruffell B, Cubillos-Ruiz J, Munn D, Shaw T, Conejo-Garcia J, Rodriguez P 2022 Cancer Cell Immuno-oncology Highplex FL HALO
Ghrelin May Inhibit Inflammatory Response and Apoptosis During Ischemia-Reperfusion Injury Fukunaga N, Ribeiro R, Bissoondath V, Billia F, Rao V 2022 Transplantation Proceedings Other Multiplex IHC HALO
Estrogen receptor beta activity contributes to both tumor necrosis factor alpha expression in the hypothalamic paraventricular nucleus and the resistance to hypertension following angiotensin II in female mice Woods C, Contoreggi N, Johnson M, Milner T, Wang G, Glass M, 2022 Neurochemistry International Neuroscience ISH/FISH HALO
CD103 and periplakin are potential biomarkers for response of metastatic melanoma to pembrolizumab Edmonds N, Flores S, Mahmutovic A, Young S, Mauldin I, Slingluff C 2022 Melanoma Research Immuno-oncology Highplex FL HALO
Mouse organoids as an in vitro tool to study the in vivo intestinal response to cytotoxicants Jardi F, Kelly C, Teague C, Fowler-Williams H, Sevin D, Rodrigues D, Jo H, Ferreira S, Herpers B, Van Heerden M, de Kok T, Pin C, Lynch A, Duckworth C, De Jonghe S, Lammens L, Pritchard D 2022 Archives of Toxicology Toxicology Multiplex IHC HALO
High endothelial venules associated with better prognosis in esophageal squamous cell carcinoma Li H, Tang L, Han X, Zhong L, Gao W, Chen Y, Huang J, Wen Z 2022 Annals of Diagnostic Pathology Oncology Object Colocalization, Spatial Analysis, Highplex FL HALO
Defactinib, pembrolizumab, and gemcitabine in patients with advanced treatment refractory pancreatic cancer: A phase I, dose escalation, and expansion study Wang-Gillam A, Lim K, McWilliams R, Suresh R, Lockhart A, Brown A, Breden M, Belle J, Herndon J, Bogner S, Pedersen K, Tan B, Boice N, Acharya A, Abdiannia M, Gao F, Yoon H, Zhu M, Trikalinos N, Ratner L, Aranha O, Hawkins W, Herzog B, DeNardo D 2022 Clinical Cancer Research Immuno-oncology Multiplex IHC, Spatial Analysis HALO
Angiotensin II Infusion Results in Both Hypertension and Increased AMPA GluA1 Signaling in Hypothalamic Paraventricular Nucleus of Male but not Female Mice Wang G, Woods C, Johnson M, Milner T, Glass M 2022 Neuroscience Neuroscience ISH/FISH HALO
Gasdermin D maintains bone mass by rewiring the endo-lysosomal pathway of osteoclastic bone resorption Li M, Yang D, Yan H, Tang Z, Jiang D, Zhang J, Chi Z, Nie W, Zhen W, Yu W, Chen S, Wang Z, Yu Q, Zhang X, Yang F, Fan S, Lin X, Wang D 2022 Developmental Cell Other Area Quantification, Multiplex IHC HALO
Micellar nanoparticles inhibit the postoperative inflammation, recurrence and pulmonary metastasis of 4T1 breast cancer by blocking NF-_B pathway and promoting MDSCs depletion Lu Z, Ma L, Mei L, Ren K, Li M, Zhang L, Liu X, He Q 2022 International Journal of Pharmaceutics Immuno-oncology Area Quantification HALO
Th1-involved immune infiltrates improve neoadjuvant chemoradiotherapy response of esophageal squamous cell carcinoma Yuan J, Weng Z, Tan Z, Luo K, Zhong J, Xie X, Qu C, Lin X, Yang H, Wen J, Fu J 2022 Cancer Letters Immuno-oncology Multiplex IHC, Spatial Analysis HALO
Evolutionary trajectory of receptor binding specificity and promiscuity of the spike protein of SARS-CoV-2 Planchais C, Reyes-Ruiz A, Lacombe R, Zarantonello A, Lecerf M, Revel M, Roumenina L, Atanasov B, Mouquet H, Dimitrov J 2022 Protein Science Infectious Disease Area Quantification, Highplex FL HALO
Novel post-acquisition image processing to attenuate red blood cell autofluorescence for quantitative image analysis Bouffard N, Lee K, DeLance N, Clason T, Chatterjee N, Taatjes D 2022 Histochemistry and Cell Biology Other Highplex FL HALO
Oct4 promoted proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT) in colon cancer cells by activating the SCF/c-Kit signaling pathway Bu X, Liu Y, Wang L, Yan Z, Xin G, Su W 2022 Cell Cycle Oncology Multiplex IHC HALO
Angiogenesis modulation-mediated inhibitory effects of tacrolimus on hypertrophic scar formation Shen Y, Jin R, Liang X, Deng Z, He J, Ding Y, Ding F, Lu L, Liu F, Yang J 2022 Microvascular Research Dermatology Highplex FL HALO
Chronic rhinosinusitis patients display an aberrant immune cell localisation with enhanced S. aureus biofilm metabolic activity and biomass Shaghayegh G, Cooksley C, Bouras G, Panchatcharam B, Idrizi R, Jana M, Ellis S, Psaltis A, Wormald P, Vreugde S 2022 Journal of Allergy and Clinical Immunology Immunology, Infectious Disease Classifier, Spatial Analysis, Highplex FL HALO
Cell-specific dysregulation of iron and oxygen homeostasis as a novel pathophysiology in PSP Lee S, Martinez-Valbuena I, de Andrea C, Villalba-Esparza M, Ilaalagan S, Couto B, Visanji N, Lang A, Kovacs G 2022 Annals of Neurology Neuroscience Area Quantification HALO
The PSEN1 E280G mutation leads to increased amyloid-_43 production in induced pluripotent stem cell neurons and deposition in brain tissue Willumsen N, Arber C, Lovejoy C, Toombs J, Alatza A, Weston P, Chavez-Gutierrez L, Hardy J, Zetterberg H, Fox N, Ryan N, Lashley T, Wray S 2022 Brain Communications Neuroscience Area Quantification HALO
Multiregional single-cell dissection of tumor and immune cells reveals stable lock-and-key features in liver cancer Ma L, Heinrich S, Wang L, Keggenhoff F, Khatib S, Forgues M, Kelly M, Hewitt S, Saif A, Hernandez J, Mabry D, Kloeckner R, Greten T, Chaisaingmongkol J, Ruchirawat M, Marquardt J, Wang X 2022 Nature Communications Oncology ISH/FISH HALO
The chromatin remodeler CHD6 promotes colorectal cancer development by regulating TMEM65-mediated mitochondrial dynamics via EGF and Wnt signaling Zhang B, Liu Q, Wen W, Gao H, Wei W, Tang A, Qin B, Lyu H, Meng X, Li K, Jin H, Yu F, Pan Q Lin J, Lee M 2022 Cell Discovery Oncology Multiplex IHC, TMA HALO
Low CD8 T Cell Counts Predict Benefit from Hypoxia-Modifying Therapy in Muscle-Invasive Bladder Cancer Smith V, Mukherjee D, Tsakiroglou A, Baker A, Mistry H, Choudhury A, Hoskin P, Illidge T, West C 2022 Cancers Immuno-oncology Highplex FL, TMA HALO
NUC-7738 regulates _-catenin signalling resulting in reduced proliferation and self-renewal of AML cells Shahid A, Um I, Elshani M, Zhang Y, Harrison D 2022 PLOS One Oncology Highplex FL HALO, HALO AI
Quantitative Dual-Energy Computed Tomography Image Guidance for Thermochemical Ablation: in vivo Results in the Rabbit VX2 Model Thompson E, Fowlkes N, Jacobsen M, Layman R, Cressman E 2022 Journal of Vascular and Interventional Radiology Oncology Classifier HALO
A noninvasive iRFP713 p53 reporter reveals dynamic p53 activity in response to irradiation and liver regeneration in vivo Humpton T, Hock A, Kiourtis C, De Donatis, Fercoq F, Nixon C, Bryson S, Strathdee D, Carlin L, Bird T, Blyth K, Vousden K 2022 Science Signaling Other Cytonuclear HALO
Identification and validation of DPY30 as a prognostic biomarker and tumor immune microenvironment infiltration characterization in esophageal cancer Mei P, Xiao H, Guo Q, Meng W, Wang M, Huang Q, Liao Y 2022 Oncology Letters Oncology Multiplex IHC HALO
Innate immune receptor C5aR1 regulates cancer cell fate and can be targeted to improve radiotherapy in tumours with immunosuppressive microenvironments Beach C, MacLean D, Majorova D, Melemenidis S, Nambiar D, Kim R, Valbuena G, Guglietta S, Krieg C, Darvish D, Suwa T, Eason A, Domingo E, Moon E, Jiang D, Jiang Y, Koong A, Woodruff T, Graves E, Maughan T, Buczacki S, Stucki M, Le Q-T, Leedham S, Giaccia A, Olcina M 2023 bioRxiv Immuno-oncology Classifier, Area Quantification, Highplex FL HALO
URI alleviates tyrosine kinase inhibitors-induced ferroptosis by reprogramming lipid metabolism in p53 wild-type liver cancers Ding Z-W, Pan Y-F, Shang T, Jiang T-Y, Lin Y-K, Yang C, Pang S, Cui X-W, Wang Y, Feng X, Xu M, Pei M, Chen Y, Li X, Ding J, Tan Y-X, Wang H, Dong L-W, Wang L 2023 Research Square Oncology Area Quantification HALO
Intranasal mRNA-LNP vaccination protects hamsters from SARS-CoV-2 infection Vaca G, Meyer M, Cadete A, Hsiao C, Golding A, Jeon A, Jacquinet E, Azcue E, Guan C, Sanchez-Felix X, Pietzsch C, Mire C, Hyde M, Comeaux M, Williams J, Sung J, Carfi A, Edwards D, Bukreyev A, Bahl K 2023 bioRxiv Infectious Disease Multiplex IHC HALO
Single-cell RNA sequencing identifies a population of human liver-type ILC1s Kramer B, Nalin A, Ma F, Eickoff S, Lutz P, Leonardelli S, Foeser F, Finnemann C, Hack G, Raabe J, ToVinh M, Ahmad S, Hoffmeister C, Kaiser K, Manekeller S, Branchi V, Bald T, Holzel M, Huneburg R, Nischalke H, Semaan A, Langhans B, Kaczmarek D, Benner B, Lordo M, Kowalski J, Gerhardt A, Timm J, Toma M, Mohr R, Turler A, Charpentier A, van Bremen T, Felmann G, Sattler A, Kotsch K, Abdallah A, Strassburg C, Spengler U, Carson W, Mundy-Bosse B, Pellegrini M, O'Sullivan T, Greud A, Nattermann J 2023 Cell Reports Immunology Highplex FL HALO
Prognostic Value of CD8+ Lymphocytes in Hepatocellular Carcinoma and Perineoplastic Parenchyma Assessed by Interface Density Profiles in Liver Resection Samples Stulpinas R, Zilenaite-Petrulaitiene D, Rasmusson A, Gulla A, Grigonyte A, Strupas K, Laurinavicius A 2023 Cancers Oncology Multiplex IHC, HALO AI HALO, HALO AI
Vascular injury is associated with repetitive head impacts and tau pathology in chronic traumatic encephalopathy Kirsch D, Shah A, Dixon E, Kelley H, Cherry J, Xia W, Daley S, Aytan N, Cormier K, Kubilus C, Mathias R, Alvarez V, Huber B, McKee A, Stein T 2023 Journal of Neuropathology & Experimental Neurology Neuroscience Area Quantification HALO
Tertiary lymphoid structures in desmoplastic melanoma have increased lymphocyte density, lymphocyte proliferation, and immune cross talk with tumor when compared to non-desmoplastic melanomas Edmonds N, Gradecki S, Katyal P, Lynch K, Stowman A, Gru A, Engelhard V, Slingluff Jr. C, Mauldin I 2023 OncoImmunology Immuno-oncology Highplex FL HALO
Autologous T cell therapy for MAGE-A4+ solid cancers in HLA-A*02+ patients: a phase 1 trial Hong D, Van Tine B, Biswas S, McAlpine C, Johnson M, Olszanski A, Clarke J, Araujo D, Blumenschein G, Kebriaei P, Lin Q, Tipping A, Sanderson J, Wang R, Trivedi T, Annareddy T, Bai J, Rafail S, Sun A, Fernandes L, Navenot J-M, Bushman F, Everett J, Karadeniz D, Broad R, Isabelle M, Naidoo R, Bath N, Betts G, Wolchinsky Z, Batrakou D, Van Winkle E, Elefant E, Ghobadi A, Cashen A, Grand'Maison A, McCarthy P, Fracasso P, Norry E, Williams D, Druta M, Liebner D, Odunsi K, Butler M 2023 Nature Medicine Immuno-oncology ISH/FISH, Spatial Analysis, Highplex FL HALO
A Cdh3-β-catenin-laminin signaling axis in a subset of breast tumor leader cells control leader cell polarization and directional collective migration Hwang P, Mathur J, Cao Y, Almeida J, Ye J, Morikis V, Cornish D, Clarke M, Stewart S, Pathak A, Longmore G 2023 Developmental Cell Oncology Highplex FL, Registration HALO
Guidelines for visualization and analysis of DC in tissues using multiparameter fluorescence microscopy imaging methods Bayer F, Bejarano D, Bartacchi G, Doffin A-C, Gobbini E, Hubert M, Li L, Meiser P, Pedde A-M, Posch W, Rupp L, Schlitzer A, Schmitz M, Schraml B, Uderhardt S, Balladeau-Guilemond J, Wilflingseder D, Zaderer V, Bottcher J 2023 European Journal of Immunology Other Highplex FL HALO
Protocol for investigating tertiary lymphoid structures in human and murine fixed tissue sections using Opal‚Ñ¢-TSA multiplex immunohistochemistry Quigley L, Pang L, Tavancheh E, Ernst M, Behren A, Huynh J, Da Gama Duarte J 2023 STAR Protocols Other Highplex FL HALO
Spike and nsp6 are key determinants of SARS-CoV-2 Omicron BA.1 attenuation Chen D-Y, Chin C, Kenney D, Tavares A, Khan N, Conway H, Liu G, Choudhary M, Gertje H, O'Connell A, Adams S, Kotton D, Herrmann A, Ensser A, Connor J, Bosmann M, Li J, Gack M, Baker S, Kirchdoerfer R, Kataria Y, Crossland N, Douam F, Saeed M 2023 Nature Infectious Disease Area Quantification HALO
ProNGF Expression and Targeting in Glioblastoma Multiforme Marsland M, Dowdell A, Faulkner S, Jobling P, Rush R, Gedye C, Lynam J, Griffin C, Baker M, Marsland J, Jiang C, Hondermarck H 2023 International Journal of Molecular Sciences Oncology Cytonuclear HALO
Standardized pathology screening of mature Tertiary Lymphoid Structures in cancers Vanhersecke L, Bougouin A, Crombe A, Brunet M, Sofeu C, Parrens M, Pierron H, Bonhomme B, Lembege N, Rey C, Velasco V, Soubeyran I, Begueret H, Bessede A, Bellera C, Scoazec J-Y, Italiano A, Fridman C, Fridman W, Le Loarer F 2023 Laboratory Investigation Other Highplex FL, Registration HALO
Effects of electroacupuncture on the kisspeptin-gonadotropin-releasing hormone (GnRH) /luteinizing hormone (LH) neural circuit abnormalities and androgen receptor expression of kisspeptin/neurokinin B/dynorphin neurons in PCOS rats. Xu G, Zhao X, Li Z, Hu J, Li X, Li J, Chen Y 2023 Journal of Ovarian Research Other Highplex FL HALO
In vivo induction of activin A-producing alveolar macrophages supports the progression of lung cell carcinoma Taniguchi S, Matsui T, Kimura K, Funaki S, Miyamoto Y, Uchida Y, Sudo T, Kikuta J, Hara T, Motooka D, Liu Y-C, Okuzaki D, Morii E, Emoto N, Shintani Y, Ishii M 2023 Nature Communications Immuno-oncology Multiplex IHC HALO
Transcriptional vulnerabilities of striatal neurons in human and rodent models of Huntington’s disease Matsushima A, Pineda S, Crittenden J, Lee H, Galani K, Mantero J, Tombaugh G, Kellis M, Heiman M, Graybiel A 2023 Nature Communications Neuroscience Area Quantification, ISH-IHC/FISH-IF HALO
Extensive and Persistent Extravascular Dermal Fibrin Deposition Characterizes Systemic Sclerosis Browning J, Bhawan J, Tseng A, Crossland N, Bujor A, Akassoglou K, Assassi S, Skaug B, Ho J 2023 bioRxiv Fibrosis Area Quantification HALO
Pretreatment with 3-methyladenine ameliorated Pseudomonas aeruginosa-induced acute pneumonia by inhibiting cell death of neutrophils in a mouse infection model Yue L, Qi J, Yuan J, Wang X, Wang Y, Shan B, Ke H, Li H, Luan N, Liu C 2023 International Journal of Medical Microbiology Infectious Disease Multiplex IHC HALO
Butyrate alleviates cognitive impairment by improving gut mucosal barrier function and blocking neuroinflammatory signaling in LDLR -/- mice Song R, Gao H, Jiang H, Zhang W, Han S 2023 Research Square Neuroscience, Metabolism Area Quantification HALO
Fucosylation of HLA-DRB1 regulates CD4+ T cell-mediated anti-melanoma immunity and enhances immunotherapy efficacy Lester D, Burton C, Gardner A, Innamarato P, Kodumudi K, Liu Q, Adhikari E, Ming Q, Williamson D, Frederick D, Sharova T, White M, Markowitz J, Cao B, Nguyen J, Johnson J, Beatty M, Mockabee-Macias A, Mercurio M, Watson G, Chen P-L, McCarthy S, MoranSegura C, Messina J, Thomas K, Darville L, Izumi V, Koomen J, Pilon-Thomas S, Ruffell B, Luca V, Haltiwanger R, Wang X, Wargo J, Boland G, Lau E 2023 Nature Cancer Immuno-oncology Highplex FL, Registration HALO
Polycomb deficiency drives a FOXP2-high aggressive state targetable by epigenetic inhibitors Chen F, Byrd A, Liu J, Flight R, DuCote T, Naughton K, Song X, Edgin A, Lukyanchuk A, Dixon D, Gosser C, Esoe D-P, Jayswal R, Orkin S, Moseley H, Wang C, Brainson C 2023 Nature Communications Oncology Multiplex IHC, HALO AI HALO, HALO AI
Inhibition of indoleamine dioxygenase leads to better control of tuberculosis adjunctive to chemotherapy Singh B, Moodley C, Singh D, Escobedo R, Sharan R, Arora G, Ganatra S, Shivanna V, Gonzalez O, Hall-Ursone S, Dick Jr. E, Kaushal D, Alvarez X, Mehra S 2023 JCI Insight Infectious Disease, Fibrosis Area Quantification, Highplex FL HALO
Combined KRASG12C and SOS1 inhibition enhances and extends the anti-tumor response in KRASG12C-driven cancers by addressing intrinsic and acquired resistance Thatikonda V, Lu H, Jurado S, Kostyrko K, Bristow C, Bosch K, Feng N, Gao S, Gerlach D, Gmachi M, Lieb S, Jeschko A, Machado A, Marszalek E, Mahendra M, Jaeger P, Sorokin A, Strauss S, Trapani F, Kopetz S, Vellano C, Petronczki M, Kraut N, Heffernan T, Marszalek J, Pearson M, Waizenegger I, Hofmann M 2023 bioRxiv Oncology ISH/FISH, Multiplex IHC, Highplex FL, Figure Maker HALO
Prefrontal cortical protease TACE/ADAM17 is involved in neuroinflammation and stress-related eating alterations Sharafeddin F, Ghaly M, Simon T, Ontiveros-Angel P, Figueroa J 2023 bioRxiv Neuroscience ISH/FISH HALO
Long noncoding RNA LINC01594 inhibits the CELF6-mediated splicing of oncogenic CD44 variants to promote colorectal cancer metastasis. Liu B, Song A, Gui P, Wang J, Pan Y, Li C, Li S, Zhang Y, Jiang T, Xu Y, Huo F, Pei D, Song J 2023 Research Square Oncology ISH/FISH HALO
Combined PD-1, BRAF and MEK inhibition in BRAFV600E colorectal cancer: a phase 2 trial Tian J, Chen J, Chao S, Pelka K, Giannakis M, Hess J, Burke K, Jorgji V, Sindurakar P, Braverman J, Mehta A, Oka T, Huang M, Lieb D, Spurrell M, Allen J, Abrams T, Clark J, Enzinger A, Enzinger P, Klempner S, McCleary N, Meyerhardt J, Ryan D, Yurgelun M, Kanter K, Van Seventer E, Baiev I, Chi G, Jarnagin J, Bradford W, Wong E, Michel A, Fetter I, Siravegna G, Gemma A, Sharpe A, Demehri S, Leary R, Campbell C, Yilmaz Om Getz G, Parikh A, Hacohen N, Corcoran R 2023 Nature Medicine Oncology Highplex FL HALO
CD47-Dependent Regulation of Immune Checkpoint Gene Expression and MYCN mRNA Splicing in Murine CD8 and Jurkat T Cells Kaur S, Awad D, Finney R, Meyer T, Singh S, Cam M, Karim B, Warner A, Roberts D 2023 International Journal of Molecular Sciences Immuno-oncology ISH/FISH HALO
Altered MANF Expression in Pancreatic Acinar and Ductal Cells in Chronic Alcoholic Pancreatitis: A Cross-Sectional Study Caldwell N, Li H, Bellizzi A, Luo J 2023 Biomedicines Gastroenterology Area Quantification, Cytonuclear HALO
Gold Nanoparticles for Monitoring of Mesenchymal Stem Cell–Loaded Bioresorbable Polymeric Wraps for Arteriovenous Fistulas Barcena A, Perez J, Damasco J, Bernardino M, San Valentin E, Klusman C, Martin B, Cortes A, Canlas G, Heralde III, F, Avritscher R, Fowlkes N, Bouchard R, Cheng J, Huang S, Melancon M 2023 bioRxiv Biomaterials Highplex FL HALO
Tau-RNA complexes inhibit microtubule polymerization and drive disease-relevant conformation change McMillan P, Benbow S, Uhrich R, Saxton A, Baum M, Strovas T, Wheeler J, Baker J, Liachko N, Keene C, Latimer C, Kraemer B 2023 Brain Neuroscience Area Quantification HALO
APOBEC3B coordinates R-loop to promote replication stress and sensitize cancer cells to ATR/Chk1 inhibitors Zong C, Zhang Z, Gao L, He J, Wang Y, Li Q, Liu X, Yang J, Chen D, Huang R, Zheng G, Jin X, Wei W, Jia R, Shen J 2023 Research Square Oncology Multiplex IHC HALO
CXCL9 and CXCL13 coordinately shape the immune-activated microenvironment of endometrial cancer via tertiary lymphoid structure formation Kodama M, Nagase Y, Aimono E, Nakamura K, Takamatsu R, Abe K, Yoshimura T, Chiyoda T, Yamagami W, Aoki D, Nishihara H 2023 Research Square Immuno-oncology Registration HALO
Discovery of NRG1-VII: a novel myeloid-derived class of NRG1 isoforms Berrocal-Rubio M, Pawer Y, Dinevska M, De Paoli-Iseppi R, Widodo S, Rajab N, De Nardo W, Hallab J, Li A, Mantamadiotis T, Clark M, Wells C 2023 bioRxiv Immunology Highplex FL HALO
Mouse-Adapted SARS-CoV-2 MA10 Strain Displays Differential Pulmonary Tropism and Accelerated Viral Replication, Neurodissemination, and Pulmonary Host Responses in K18-hACE2 Mice Thieulent C, Dittmar W, Balasuriya U, Crossland N, Wen X, Richt J, Carossino M 2023 mSphere Infectious Disease Area Quantification HALO
Nucleolin mediates SARS-CoV-2 replication and viral-induced apoptosis of host cells Merino V, Yan Y, Ordonez A, Bullen C, Lee A, Saeki H, Ray K, Huang T, Jain S, Pomper M 2023 Antiviral Research Infectious Disease Area Quantification, Multiplex IHC HALO
Single-cell spatial immune landscapes of primary and metastatic brain tumours Karimi E, Yu M, Maritan S, Perus L, Rezanejad M, Sorin M, Kankner M, Fallah P, Doré S, Zuo D, Fiset B, Kloosterman D, Ramsay L, Wei Y, Lam S, Alsajjan R, Watson I, Urgoiti G, Park M, Randsma D, Senger D, Chan J, Akkari L, Petrecca K, Guiot M-C, Siegel P, Quail D, Walsh L 2023 Nature Immuno-oncology Highplex FL HALO
Multiplex immune profiling reveals the role of serum immune proteomics in predicting response to preoperative chemotherapy of gastric cancer Tang Z, Gu Y, Shi Z, Min L, Zhang Z, Zhou P, Luo R, Wang Ym, Cui Y, Sun Y, Wang X 2023 Cell Reports Medicine Immuno-oncology Highplex FL HALO
Dissecting the immune suppressive human prostate tumor microenvironment via integrated single-cell and spatial transcriptomic analyses Hirz T, Mei S, Sarkar H, Kfoury Y, Wu S, Verhoeven B, Subtelny A, Zlatev D, Wszolek M, Salari K, Murray E, Chen F, Macosko E, Wu C, Scadden D, Dahl D, Baryawno N, Saylor P, Kharchenko P, Sykes D 2023 Nature Communications Immuno-oncology Highplex FL, Figure Maker, HALO AI HALO
Genetic models of cleavage-reduced and soluble TREM2 reveal distinct effects on myelination and microglia function in the cuprizone model Beckmann N, Neuhaus A, Zurbruegg S, volkmer P, Patino C, Joller S, Feuerbach D, Doelemeyer A, Schweizer T, Rudin S, Nuemann U, Berth R, Frieauff W, Gasparani F, Shimshek D 2023 Journal of Neuroinflammation Neuroscience Area Quantification HALO
A Comparative Study on the Distribution Pattern of Endocrine Cells in the Gastrointestinal Tract of Two Small Alpine Mammals, Plateau Zokor (Eospalax baileyi) and Plateau Pika (Ochotona curzoniae) Cai X, Bao D, Hua R, Cai B Wang L, Dong R, Hua L 2023 Animals Gastroenterology Area Quantification HALO
Pioglitazone restores mitochondrial function but does not spare cortical tissue following mild brain contusion Hubbard W, Vekaria H, Kalimon O, Spry M, Brown E, Kobaugh T, Sullivan P 2023 Brain Communications Neuroscience Area Quantification HALO
Impact of aging on the immunological and microbial landscape of the lung during non-tuberculous mycobacterial infection Cinco I, Rhoades N, Napier E, Davies M, Allison D, Kohama S, Bermudez L, Winthrop K, Fuss C, Spindel E, Messaoudi I 2023 bioRxiv Infectious Disease Highplex FL HALO
Somatostatin slows Aβ plaque deposition in aged APPNL-F/NL-F mice by blocking Aβ aggregation Williams D, Yan B, Wang H, Negm L, Sackmann C, Verkuyl C, Rezai-Stevens V, Eid S, Vediya N, Sato C, Watts J, Wille H, Schmitt-Ulms G 2023 Scientific Reports Neuroscience Object Colocalization HALO
Effects of KMT2D mutation and its exon 39 mutation on the immune microenvironment and drug sensitivity in colorectal adenocarcinoma Liu C, Jin Y, Zhang H, Yan J, Guo Y, Bao X, Zhao P 2023 Heliyon Oncology Highplex FL HALO
IL17A mRNA staining distinguishes palmoplantar psoriasis from hyperkeratotic palmoplantar eczema in diagnostic skin biopsies Chen J, Murphy M, Singh K, Wang A, Chow R, Kim S, Cohen J, Ko C, Damsky W 2023 JID Innovations Dermatology ISH HALO
CD8+ Cell Density Gradient across the Tumor Epithelium–Stromal Interface of Non-Muscle Invasive Papillary Urothelial Carcinoma Predicts Recurrence-Free Survival after BCG Immunotherapy Drachneris J, Rasmusson A, Morkunas M, Fabijonavicius M, Cekauskas A, Jankevicius F, Laurinavicius A 2023 Cancers Immuno-oncology Multiplex IHC, Spatial Analysis, HALO AI HALO
IL-13RA2 downregulation in fibroblasts promotes keloid fibrosis via JAK/STAT6 activation Chao H, Zheng L, Hsu P, He J, Wu R, Xu S, Zeng R, Zhou Y, Ma H, Liu H, Tang Q 2023 JCI Insight Fibrosis Multiplex IHC HALO
NADK-mediated de novo NADP(H) synthesis is a metabolic adaptation essential for breast cancer metastasis Ilter D, Drapela S, Schild T, Ward N, Adhikari E, Low V, Asara J, Oskarsson T, Lau E, DeNicola G, McReynolds M, Gomes A 2023 Redox Biology Oncology, Metabolism Classifier, Highplex FL, TMA HALO
Oncolytic BHV-1 Is Sufficient to Induce Immunogenic Cell Death and Synergizes with Low-Dose Chemotherapy to Dampen Immunosuppressive T Regulatory Cells Davola M, Cormier O, Vito A, El-Sayes N, Collins S, Salem O, Revill S, Ask K, Wan Y, Mossman K 2023 Cancers Oncology Multiplex IHC HALO
Endothelial Cells are Heterogeneous in Different Brain Regions and are Dramatically Altered in Alzheimer’s Disease Bryant A, Li Z, Jayakumar R, Serrano-Pozo A, Woost B, Hu M, Woodbury M, Wachter A, Lin G, Kwon T, Talanian R, Biber K, Karran E, Hyman B, Das S, Bennett R 2023 bioRxiv Neuroscience Area Quantification HALO
Spatial transcriptomics analysis of zone-dependent hepatic ischemia-reperfusion injury murine model Xin J, Yang T, Wu X, Wu Y, Liu Y, Liu X, Jiang M, Gao W 2023 Communications Biology Gastroenterology Highplex FL HALO
Coordinated activation of c-Src and FOXM1 drives tumor cell proliferation and breast cancer progression Nandi I, Smith H, Sanguin-Gendreau V, Ji L, Pacis A, Papavasiliou V, Zuo D, Nam S, Attala S, Kim S, Lusson S, Kuasne H, Fortier A, Savage P, Ramirez C, Park M, Katzenellenbogen J, Katzenellenbogen B, Muller W 2023 Journal of Clinical Investigation Oncology Highplex FL HALO
Oncogenic KrasG12D specific non-covalent inhibitor reprograms tumor microenvironment to prevent and reverse early pre-neoplastic pancreatic lesions and in combination with immunotherapy regresses advanced PDAC in a CD8+ T cells dependent manner Mahadevan K, McAndrews K, LeBlue V, Yang S, Lyu H, Li B, Sockwell A, Kirtley M, Morse S, Diaz B, Kim M, Feng N, Lopez A, Guerrero P, Sugimoto H, Arian K, Ying H, Barekatain Y, Kelly P, Maitra A, Heffernan T, Kalluri R 2023 bioRxiv Oncology FISH, Highplex FL HALO
In-depth virological and immunological characterization of HIV-1 cure after CCR5Δ32/Δ32 allogeneic hematopoietic stem cell transplantation Jensen B, Knops E, Cords L, Lubke N, Salgado M, Busman-Sahay K, Estes J, Huyveneers L, Perdomo-Celis F, Wittner M, Galvez C, Mummert C, Passaes C, Eberhard J, Munk C, Hauber I, Hauber J, Heger E, De Clercq J, Vandekerckhove L, Bergmann S, Dunay G, Klein F, Haussinger D, Fischer J, Nachtkamp K, Timm J, Kaiser R, Harrer T, Luedde T, Nijhuis M, Saez-Cirion A, zur Wiesch J, Wensing A, Martinez-Picado J, Kobbe G 2023 Nature Medicine Infectious Disease ISH, Figure Maker HALO
Cancer-associated fibroblasts are the main contributors to epithelial-to-mesenchymal signatures in the tumor microenvironment Szabo P, Vajdi A, Kumar N, Tolstorukov M, Chen B, Edwards R, Ligon K, Chasalow S, Chow K, Shetty A, Bolisetty M, Holloway J, Golhar R, Kidd B, Hull P, Houser J, Vlach L, Siemers N, Saha S 2023 Scientific Reports Oncology Area Quantification HALO
TGF-β in the microenvironment induces a physiologically occurring immune-suppressive senescent state Matsuda S, Revandkar A, Dubash T, Ravi A, Wittner B, Lin M, Morris R, Burr R, Guo H, Seeger K, Szabolcs A, Che D, Nieman L, Getz G, Ting D, Lawrence M, Gainor J, Haber D, Maheswaran S 2023 Cell Reports Oncology Area Quantification HALO
MYC-driven increases in mitochondrial DNA copy number occur early and persist throughout prostatic cancer progression Chen J, Zheng Q, Hicks J, Trabzonlu L, Ozbek B, Jones T, Vaghasia A, Larman T, Wang R, Markowski M, Denmeade S, Pienta K, Hruban R, Antonaraskis E, Gupta A, Dang C, Yegnasubramanian S, De Marzo A 2023 bioRxiv Oncology Classifier, Area Quantification HALO
Ubiquinone deficiency drives reverse electron transport to disrupt hepatic metabolic homeostasis in obesity Goncalves R, Wang Z, Inouye K, Lee G, Fu X, Saksi J, Rosique C, Parlakgul G, Arruda A, Hui S, Loperena M, Burgess S, Graupera I, Hotamisligil G 2023 bioRxiv Metabolism Area Quantification HALO
Feasibility of [18F]FSPG PET for Early Response Assessment to Combined Blockade of EGFR and Glutamine Metabolism in Wild-Type KRAS Colorectal Cancer Bae S, Wang J, Georgiou D, Wen X, Cohen A, Geng L, Tantawy M, Manning H 2023 Tomography Oncology Area Quantification HALO
PD-1+CD8+ T Cells Proximal to PD-L1+CD68+ Macrophages Are Associated with Poor Prognosis in Pancreatic Ductal Adenocarcinoma Patients Yang X, Wang G, Song Y, Zhuang T, Li Y, Xie Y, Fei X, Zhao Y, Xu D, Hu Y 2023 Cancers Oncology, Immuno-oncology Classifier, Spatial Analysis, Highplex FL, Registration, TMA HALO
Donor Batf3 inhibits murine lung allograft rejection and airway fibrosis Watanabe T, Lam C, Oliver J, Oishi H, Teskey G, Beber S, Boonstra K, Mauricio J, Buhari H, Joe B, Guan Z, Horie M, Keshavjee S, Martinu T, Juvet S 2023 Mucosal Immunity Other, Fibrosis Highplex FL HALO
Synergistic therapeutic combination with a CAF inhibitor enhances CAR-NK-mediated cytotoxicity via reduction of CAF-released IL-6 Lee Y, Go G, Koh E, Yoon H, Seo M, Hong S, Jeong J, Kim J, Cho D, Kim T, Kim S, Jun E, Jang M 2023 Journal for ImmunoTherapy of Cancer Immuno-oncology Area Quantification, Multiplex IHC HALO
Targeting XBP1 mRNA splicing sensitizes glioblastoma to chemotherapy Dowdell A, Marsland M, Faulkner S, Gedye C, Lynam J, Griffin C, Marsland J, Jiang C, Hondermarck H 2023 FASEB BioAdvances Oncology Classifier, Cytonuclear HALO
Loss of Hepatic Leucine-Rich Repeat-Containing G-Protein Coupled Receptors 4 and 5 Promotes Nonalcoholic Fatty Liver Disease Saponara E, Penno C, Orsini V, Wang Z, Fischer A, Aebi A, Matadamas-Guzman M, Brun V, Fischer B, Brousseau M, O'Donnell P, Turner J, Meyer A, Bollepalli L, d'Ario G, Roma G, Carbone W, Annunziato S, Obrecht M, Beckmann N, Saravanan C, Osmont A, Tropberger P, Richards S, Genoud C, Ley S, Ksiazek I, Nigsch F, Terracciano L, Schadt H, Bouwmeester T, Tchorz J, Ruffner H 2023 The American Journal of Pathology Gastroenterology Highplex FL HALO
Pan-tumor T-lymphocyte detection using deep neural networks: Recommendations for transfer learning in immunohistochemistry Wilm F, Ihling C, Méhes G, Terracciano L, Puget C, Klopfleisch R, Schüffler P, Aubreville M, Maier A, Mrowiec T, Breininger K 2023 Journal of Pathology Informatics Oncology Multiplex IHC HALO, HALO AI
Radiation-induced persistent DNA damage response and late toxicity in cardiac tissue Shigemori K, Jiang Y, Martin J, Hawkins M, Ryan A, Parkes E 2023 bioRxiv Other Multiplex IHC HALO, HALO AI
Single-cell analysis reveals changes in BCG vaccine-injected mice modeling tuberculous meningitis brain infection Zhang X, Zhao Z, Wu Q, Wang L, Li L, Wang M, Ren Y, Pan L, Tang H, Li F 2023 Cell Reports Infectious Disease Multiplex IHC, Highplex FL HALO
Notch3 regulates Mybl2 via HeyL to limit proliferation and tumor initiation in breast cancer Brahim S, Negulescu A, Geneste C, Schott T, Lin S, Morel L, Rama N, Gadot N, Treilleux I, Mehlen P, Meurette O 2023 Cell Death & Disease Oncology Multiplex IHC HALO
Spatial multi-omics revealed the impact of tumor ecosystem heterogeneity on immunotherapy efficacy in patients with advanced non-small cell lung cancer treated with bispecific antibody Song X, Xiong A, Wu F, Li X, Wang J, Jiang T, Chen P, Zhang X, Zhao Z, Liu H, Cheng L, Zhao C, Wang Z, Pan C, Cui X, Xu T, Luo H, Zhou C 2023 Journal for ImmunoTherapy of Cancer Immuno-oncology Classifier, Highplex FL HALO
Lorazepam stimulates IL-6 production and is associated with poor survival outcomes in pancreatic cancer Cornwell A, Tisdale A, Venkat S, Maraszek K, Alahmari A, George A, Attwood K, George M, Rempinski D, Franco-Barraza J, Parker M, Gomez E, Fountzilas C, Cukierman E, Steele N, Feigin M 2023 medrxiv Oncology FISH-IF HALO
Electroacupuncture Zusanli (ST36) Relieves Somatic Pain in Colitis Rats by Inhibiting Dorsal Root Ganglion Sympathetic-Sensory Coupling and Neurogenic Inflammation Wang Y, Zhu H, Lv X, Ren X, Peng Y, Qu J, Shen X, Sun R, Xiao M, Zhang H, Chen Z, Cong P 2023 Neural Plasticity Neuroscience Multiplex IHC HALO
Myeloid-specific deletion of activating transcription factor 6 alpha increases CD11b+ macrophage subpopulations and aggravates lung fibrosis Mekhael O, Revill S, Hayat A, Cass S, MacDonald K, Vierhout M, Ayoub A, Reihani A, Padwal M, Imani J, Ayaub E, Yousof T, Dvorkin-Gheva A, Rullo A, Hirota J, Richards C, Bridgewater D, Stämpfli M, Hambly N, Naqvi A, Kolb M, Ask K 2023 Immunology and Cell Biology Immunology, Fibrosis Classifier, Area Quantification, FISH, Multiplex IHC HALO
Melanotransferrin Functions as a Pro-Oncogenic WNT Agonist: A Yin-Yang Relationship in Melanoma with the WNT Antagonist and Metastasis Suppressor, NDRG1 Paluncic J, Cholam M, Lane D, Skoda J, Park K, Chiang S, Bae D, Scolyer R, Afroz R, Babu G, Wilmott J, Loh K, Jansson P, Dharmasiviam M, Huang M, Zhao X, Kovacevic Z, Richardson D 2023 bioRxiv Oncology Highplex FL HALO
Co-enrichment of CD8-positive T cells and macrophages is associated with clinical benefit of tislelizumab in solid tumors Ye D, Desai J, Shi J, Liu S, Shen W, Liu T, Shi Y, Wang D, Liang L, Yang S, Ma X, Jin W, Zhang P, Huang R, Shen Z, Zhang Y, Wu Y 2023 Biomarker Research Immuno-oncology Spatial Analysis, Highplex FL HALO
Cannabinoids modulate the microbiota–gut–brain axis in HIV/SIV infection by reducing neuroinflammation and dysbiosis while concurrently elevating endocannabinoid and indole-3-propionate levels McDew-White M, Lee E, Premadasa L, Alvarez X, Okeoma C, Mohan M 2023 Journal of Neuroinflammation Neuroscience, Infectious Disease Area Quantification HALO
Single-cell profiling reveals pathogenic role and differentiation trajectory of granzyme K+ CD8+T cells in primary Sjögren’s syndrome Xu T, Zhu H, Ma J, Li X, Luo P, Li Y, Lian Z, Gao C 2023 JCI Insight Immunology Highplex FL HALO
Morphology-guided transcriptomic analysis of human pancreatic cancer organoids reveals microenvironmental signals that enhance invasion Jeong Y, Knutsdottir H, Shojaeian F, Lerner M, Wissler M, Henriet E, Ng T, Datta S, Navarro-Serer B, Chianchiano P, Kinny-Koster B, Zimmerman J, Stein-O'Brien G, Gaida M, Eshleman J, Lin M, Fertig E, Ewald A, Bader J, Wood L 2023 The Journal of Clinical Investigation Oncology Multiplex IHC HALO
Free fatty acids induce coronary microvascular dysfunction via inhibition of the AMPK/KLF2/eNOS signaling pathway Zhang Y, Zhao J, Ren C, Hu B, Ding R, He Z, Liang C 2023 International Journal of Molecular Medicine Other Multiplex IHC HALO
Metabolic profiling stratifies colorectal cancer and reveals adenosylhomocysteinase as a therapeutic target Voorde J, Najumudeen A, Steven R, Nikula C, Dexter A, Zeiger L, Elia E, Nasif A, Conzalez-Fernandez A, Murta T, Gillespie M, Ford C, Lannagan T, Vlahov N, Ridgeway R, Nixon C, Gilroy K, Gay D, Burton A, Yan B, Sellers K, Wu V, Xiang Y, Shokry E, Clark W, Li V, Barry S, Goodwin R, Takats Z, Maddocks O, Sumpton D, Yuneva M, Campbell A, Bunch J, Sansom O 2023 bioRxiv Oncology ISH HALO
SARS-CoV-2 infection induces DNA damage, through CHK1 degradation and impaired 53BP1 recruitment, and cellular senescence Gioia U, Tavella S, Martinez-Orellana P, Cicio G, Colliva A, Ceccon M, Cabrini M, Henriques A, Fumagalli V, Paldino A, Presot E, Rajasekharan S, Iacomino N, Pisati F, Matti V, Sepe S, Conte M, Barozzi S, Lavagnino Z, Carletti T, Volpe M, Cavalcante P, Iannacone M, Rampazzo C, Bussani R, Tripodo C, Zacchigna S, Marcello A, di Fagagna F 2023 Nature Cell Biology Infectious Disease ISH/FISH, Highplex FL HALO
Tyrosinase-induced neuromelanin accumulation triggers rapid dysregulation and degeneration of the mouse locus coeruleus Iannitelli A, Segal A, Pare J, Mulvey B, Liles L, Sloan S, McCann K, Dougherty J, Smith Y, Weinshenker D 2023 bioRxiv Neuroscience FISH-IF HALO
TIPE2 Inhibits MGD Inflammation by Regulating Macrophage Polarization Zhao S, Shen Y, Wu S, Shao Y, Shi R, Yan Y, Zhao H 2023 Journal of Personalized Medicine Immunology Area Quantification, Highplex FL HALO
Loss of Peroxiredoxin IV Protects Mice from Azoxymethane/Dextran Sulfate Sodium-Induced Colorectal Cancer Development Thapa P, Jiang H, Ding N, Hao Y, Alshahrani A, Lee E, Fujii J, Wei Q 2023 Antioxidants Oncology Multiplex IHC, Highplex FL HALO
Cellular mechanisms of heterogeneity in NF2-mutant schwannoma Chiasson-MacKenzie C, Vitte J, Liu C, Wright E, Flynn E, Stott S, Giovannini M, McClatchey A 2023 Nature Communications Oncology Classifier, Multiplex IHC, Spatial Analysis, FISH-IF HALO
Bi-allelic mutation in SEC16B alters collagen trafficking and increases ER stress El-Gazzar A, Voraberger B, Rauch F, Mairhofer M, Schmidt K, Guillemyn B, Mitulovic G, Reiterer V, Haun M, Mayr M, Mayr J, Kimeswenger S, Drews O, Saraff V, Shaw N, Fratzl-Zelman N, Symoens S, Farhan H, Hogler W 2023 EMBO Molecular Medicine Other Area Quantification, Highplex FL HALO
Tumour Extracellular Vesicles Induce Neutrophil Extracellular Traps To Promote Lymph Node Metastasis Su X, Brassard A, Bartolomucci A, Dhoparee-Dooma I, Qiu Q, Tsering T, Rohanizadeh R, Koufos O, Giannias B, Bourdeau F, Feng L, Leo S, Sangwan V, Tankel J, Quail D, Spicer J, Burnier J, Bailey S, Ferri L, Cools-Lartigue J 2023 bioRxiv Immuno-oncology Area Quantification, Highplex FL HALO
The localization of molecularly distinct microglia populations to Alzheimer's disease pathologies using QUIVER Shahidehpour R, Nelson A, Sanders L, Embry C, Nelson P, Bachstetter A 2023 Acta Neuropathologica Communications Neuroscience Area Quantification, Object Colocalization, Spatial Analysis, Registration
Immune and pathologic responses in patients with localized prostate cancer who received daratumumab (anti-CD38) or edicotinib (CSF-1R inhibitor) Siddiqui B, Chapin B, Jindal S, Duan F, Basu S, Yadav S, Gu A, Espejo A, Kinder M, Pettaway C, Ward J, Tidwell R, Troncoso P, Corn P, Logothetis C, Knoblauch R, Hutnick N, Gottardis M, Drake C, Sharma P, Subudhi S 2023 Journal for ImmunoTherapy of Cancer Immuno-oncology Multiplex IHC, Figure Maker HALO
Interpretable histopathology-based prediction of disease relevant features in Inflammatory Bowel Disease biopsies using weakly-supervised deep learning Mokhtari R, Hamidinekoo A, Sutton D, Lewis A, Angermann B, Gehrmann U, Lundin P, Adissu H, Cairns J, Neisen J, Khan E, Marks D, Khachapuridze N, Qaiser T, Burlutskiy N 2023 arXiv Gastroenterology HALO, HALO Link
Pseudoknot-targeting Cas13b combats SARS-CoV-2 infection by suppressing viral replication Yu D, Han H, Yu J, Kim J, Lee G, Yang J, Song B, Tark D, Choi B, Kang S, Heo W 2023 Molecular Therapy Infectious Disease ISH, FISH-IF HALO
YBX1 integration of oncogenic PI3K/mTOR signalling regulates the fitness of malignant epithelial cells Bai Y, Gotz C, Chincarini G, Zhao Z, Slaney C, Boath J, Furic L, Angel C, Jane S, Phillips W, Stacker S, Farah C, Darido C 2023 Nature Communications Oncology Classifier, Multiplex IHC HALO
Sustained delivery of a heterodimer bone morphogenetic protein-2/7 via a collagen hydroxyapatite scaffold accelerates and improves critical femoral defect healing Liu Y, Puthia M, Sheehy E, Ambite I, Petrlova J, Prithviraj S, Oxborg M, Sebastian S, Vater C, Zwingenberger S, Struglics A, Bourgine P, O'Brien F, Raina D 2023 Acta Biomaterialia Biomaterials Area Quantification, Figure Maker HALO
Soluble TNF mediates amyloid-independent, diet-induced alterations to immune and neuronal functions in an Alzheimer’s disease mouse model MacPherson K, Eidson L, Houser M, Weiss B, Gollihue J, Herrick M, Rodrigues M, Sniffen L, Weekman E, Hamilton A, Kelly S, Oliver D, Yang Y, Chang J, Sampson T, Norris C, Tansey M 2023 Frontiers in Cellular Neuroscience Neuroscience Object Colocalization HALO
Repertoire of P-glycoprotein drug transporters in the zoonotic nematode Toxocara canis Chelladurai J, Martin K, Vardaxis P, Reinemeyer C, Vijayapalani P, Robertson A, Brewer M 2023 Scientific Reports Infectious Disease Area Quantification HALO
Chronic immune activation and gut barrier dysfunction is associated with neuroinflammation in ART-suppressed SIV+ rhesus macaques Byrnes S, Busman-Sahay K, Angelovich T, Younger S, Taylor-Brill S, Nekorchuk M, Bondoc S, Dannay R, Terry M, Cochrane C, Jenkins T, Roche M, Deleage C, Bosinger S, Paiardini M, Brew B, Estes J, Churchill M 2023 PLOS Pathogens Infectious Disease Area Quantification, Object Colocalization, ISH, Highplex FL HALO
Development of a deep pathomics score for predicting hepatocellular carcinoma recurrence after liver transplantation Qu W, Tian M, Lu G, Zhou Y, Liu W, Tang Z, Yao Z, Huang R, Zhu G, Jiang X, Tao C, Fang Y, Gao J, Wu X, Chen J, Zhao Q, Yang R, Chu T, Zhou J, Fan J, Yu J, Shi Y 2023 Hepatology International Oncology Spatial Analysis, Highplex FL HALO
MAIT cell inhibition promotes liver fibrosis regression via macrophage phenotype reprogramming Mabire M, Hegde P, Hammoutene A, Wan J, Caër C, Al Sayegh R, Cadoux M, Allaire M, Weiss E, Thibault-Sogorb T, Lantz O, Goodhardt M, Paradis V, de la Grange P, Gilgenkrantz H, and Lotersztajn S 2023 Nature Communications Gastroenterology Area Quantification HALO
Clinical, histopathological and molecular features of dedifferentiated melanomas: An EORTC Melanoma Group Retrospective Analysis Hench J, Mihic-Probst D, Agaimy A, Frank S, Meyer P, Hultschig C, Simi S, Alos L, Balamurugan T, Blokx W, Bosisio F, Cappellesso R, Griewank K, Hadaschik E, van Kempen LC, Kempf W, Lentini M, Mazzucchelli L, Rinaldi G, Rutkowski P, and Massi D 2023 European Journal of Cancer Oncology HALO, HALO Link
HX009, a novel BsAb dual targeting PD1 x CD47, demonstrates potent anti-lymphoma activity in preclinical models Ke H, Zhang F, Wang J, Xiong L, An X, Tu X, Chen C, Wang Y, Mao B, Guo S, Ju C, He X, Sun R, Zhang L, O'Connor O, Li Q 2023 Scientific Reports Immuno-oncology Multiplex IHC HALO
Early Identication of High-Risk Patients with HCC Relapse: A Spatial Immune Scoring System Enabled by Articial Intelligence Sun C, Jia G, He P, Goh D, Li F, Wee F, Sun M, Dai T, Lim J, Hao S, Liu L, Yeong J, Tian Z 2023 Research Square Oncology Highplex FL HALO
Cancer cell genotype associated tumor immune microenvironment exhibits differential response to therapeutic STING pathway activation in high-grade serous ovarian cancer Shakfa N, Li D, Conseil G, Lightbody E, Wilson-Sanchez J, Hamade A, Chenard S, Jawa N, Laight B, Afriyie-Asante A, Tyryshkin K, Koebel M, and Koti M 2023 Journal for ImmunoTherapy of Cancer Oncology Highplex FL HALO, HALO Link
Prognostic value of tumor immune microenvironment factors in patients with stage I lung adenocarcinoma Xue Q, Wang Y, Zheng Q, Chen L, Lin Y, Jin Y, Shen X, Li Y 2023 American Journal of Cancer Research Oncology Classifier, Multiplex IHC, Highplex FL HALO
An Immune-Related Gene Expression Signature Predicts Benefit from Adding Atezolizumab to FOLFOXIRI plus Bevacizumab in Metastatic Colorectal Cancer Antoniotti C, Boccaccino A, Seitz R, Giordano M, Catteau A, Rossini D, Pietrantonio F, Salvatore L, McGregor K, Bergamo F, Conca V, Leonetti S, Morano F, Papiani G, Tamburini E, Bensi M, Murgioni S, Ross D, Passardi A, Boquet I, Nielsen T, Galon J, Varga M, Schweitzer B, and Cremolini C 2023 Clinical Cancer Research Immuno-oncology Multiplex IHC, Spatial Analysis HALO
Booster with Ad26.COV2.S or Omicron-adapted vaccine enhanced immunity and efficacy against SARS-CoV-2 Omicron in macaques Solforosi L, Costes L, Tolboom J, McMahan K, Anioke T, Hope D, Murdza T, Sciacca M, Bouffard E, Barrett J, Wu C, Hachmann N, Miller J, Yu J, He X, Jacob-Dolan C, Rosendahl Huber S, Dekking L, Chamanza R, Choi Y, Feddes-de Boer K, Barouch D, Schuitemaker H, Zahn R, and Wegmann F 2023 Nature Communications Infectious Disease HALO, HALO Link
Immune Checkpoint Neuropilins as Novel Biomarkers and Therapeutic Targets for Pancreatic Cancer He L, Zhang X, Lao M, Zhang H, Yang H, Bai X 2023 Cancers Immuno-oncology Highplex FL HALO
Cannabinoid enhancement of lncRNA MMP25-AS1/MMP25 interaction reduces neutrophil infiltration and intestinal epithelial injury in HIV/SIV infection Premadasa L, Lee E, McDew-White M, Alvarez X, Jayakumar S, Ling B, Okeoma C, Byrareddy S, Kulkarni S, and Mohan M 2023 JCI Insight Infectious Disease Area Quantification, Highplex FL HALO
Industrialized, Artificial Intelligence-guided Laser Microdissection for Microscaled Proteomic Analysis of the Tumor Microenvironment Mitchell D, Hunt A, Conrads K, Hood B, Makohon-Moore S, Rojas C, Maxwell G, Bateman N, Conrads T 2022 JOVE Other Classifier HALO
Single-cell and spatial transcriptome analysis reveals the cellular heterogeneity of liver metastatic colorectal cancer Wang F, Long J, Li L, Wu Z, Da T, Wang X, Huang C, Jiang Y, Yao X, Ma H, Lian Z, Zhao Z, Cao J 2023 Science Advances Oncology Multiplex IHC, Spatial Analysis, Highplex FL HALO
Dissecting tumor lymphocyte infiltration to predict benefit from immune-checkpoint inhibitors in metastatic colorectal cancer: lessons from the AtezoTRIBE study Moretto R, Rossini D, Catteau A, Antoniotti C, Giordano M, Boccaccino A, Ugolini C, Proietti A, Conca V, Kassambara A, Pietrantonio F, Salvatore L, Lonardi S, Tamberi S, Tamburini E, Poma A, Fieschi J, Fontanini G, Masi G, Galon J, Cremolini C 2023 Journal for ImmunoTherapy of Cancer Immuno-oncology Multiplex IHC, Spatial Analysis HALO
High tumor mutational burden predicts favorable response to anti-PD-(L)1 therapy in patients with solid tumor: a real-world pan-tumor analysis Jung J, Heo Y, Park S 2023 Journal for ImmunoTherapy of Cancer Immuno-oncology Spatial Analysis, Highplex FL HALO
Transcriptional-translational conflict is a barrier to cellular transformation and cancer progression Jana S, Brahma S, Arora S, Wladyka C, Hoang P, Blinka S, Hough R, Horn J, Liu Y, Wang L, Depeille P, Smith E, Montgomery R, Lee J, Haffner M, Vakar-Lopez F, Grivas P, Wright J, Lam H, Black P, Roose J, Ryazanov A, Subramaniam A, Henikoff S, and Hsieh A 2023 Cancer Cell Oncology Multiplex IHC, Highplex FL HALO
Disrupting the α-synuclein-ESCRT interaction with a peptide inhibitor mitigates neurodegeneration in preclinical models of Parkinson’s disease Nim S, O'Hara D, Corbi-Verge C, Perez-Riba A, Fujisawa K, Kapadia M, Chau H, Albanese F, Pawar G, De Snoo M, Ngana S, Kim J, El-Agnaf O, Rennella E, Kay L, Kalia S, Kalia L, Kim P 2023 Nature Communications Neuroscience Area Quantification HALO
Dedifferentiation maintains melanocyte stem cells in a dynamic niche Sun Q, Lee W, Hu H, Ogawa T, De Leon S, Katehis I, Lim C, Takeo M, Cammer M, Taketo M, Gay D, Millar S, Ito M 2023 Nature Other FISH Nature
In situ microwave fixation provides an instantaneous snapshot of the brain metabolome Juras J, Webb M, Young L, Markussen K, Hawkinson T, Buoncristiani M, Bolton K, Coburn P, Williams M, Sun L, Sanders W, Bruntz R, Conroy L, Wang C, Gentry M, Smith B, Sun R 2023 Cell Reports Methods Other Area Quantification HALO
Phase I/II sequencing study of azacitidine, epacadostat, and pembrolizumab in advanced solid tumors Luke J, Fakih M, Schneider C, Chiorean E, Bendell J, Kristeleit R, Kurzrock R, Blagden S, Brana I, Goff L, O'Hayer K, Geschwindt R, Smith M, Zhou F, Naing A 2023 British Journal of Cancer Immuno-oncology Multiplex IHC HALO
Targeting DRP1 mediated mitochondrial metabolism as a novel treatment strategy for triple negative breast cancer (TNBC) Wang Y, Harada-Shoji N, Kitamura N, Yamazaki Y, Ebata A, Amari M, Watanabe M, Miyashita M, Tada H, Abe T, Suzuki T, Gonda K, Ishida T 2023 Research Square Oncology Multiplex IHC HALO
Dual truncation of tau by caspase-2 accelerates its CHIP-mediated degradation Reinhardt L, Musacchio F, Bichmann M, Behrendt A, Ercan-Herbst E, Stein J, Becher I, Haberkant P, Mader J, Schöndorf D, Schmitt M, Korffmann J, Reinhardt P, Pohl C, Savitski M, Klein C, Gasparini L, Fuhrmann M, Ehrnhoefer D 2023 Neurobiology of Disease Neuroscience Area Quantification HALO
Geospatial characterization of immune cell distributions and dynamics across the microenvironment in clear cell renal cell carcinoma Chakiryan N, Kim Y, Berglund A, Chang A, Kimmel G, Hajiran A, Nguyen J, Moran-Segura C, Saeed-Vafa D, Katende E, Lopez-Blanco N, Chahoud J, Rappold P, Spiess P, Fournier M, Jeong D, Wang L, Teer J, Dhillon J, Kuo F, Hakimi A, Altrock P, Mulé J, Manley B 2023 Journal for ImmunoTherapy of Cancer Immuno-oncology Highplex FL HALO
Adrenal cortex size and homeostasis are regulated by gonadal hormones via androgen receptor/β-catenin signaling crosstalk Lyraki R, Grabek A, Tison A, Weerasinghe-Arachchige L, Peitzsch M, Bechman N, Youssef S, de Bruin A, Bakker E, Claessens F, Chaboissier M, Schedl A 2023 Disease Models & Mechanisms Other FISH, Highplex FL HALO
Immunomodulatory amnion-derived mesenchymal stromal cells preserve muscle function in a mouse model of Duchenne muscular dystrophy Nitahara-Kasahara Y, Nakayama S, Kimura K, Yamaguchi S, Kakiuchi Y, Nito C, Hayashi M, Nakaishi T, Ueda Y, Okada T 2023 Stem Cell Research & Therapy Myology Area Quantification HALO
Neural mechanism of acute stress regulation by trace aminergic signalling in the lateral habenula in male mice Yang S, Yang E, Lee J, Kim J, Yoo H, Park H, Jung J, Lee D, Chun S, Jo Y, Pyeon G, Park J, Lee H, Kim H 2023 Nature Communications Neuroscience FISH HALO
Multi-organ landscape of therapy-resistant melanoma Liu S, Dharanipragada P, Lomeli S, Wang Y, Zhang X, Yang Z, Lim R, Dumitras C, Scumpia P, Dubinett S, Moriceau G, Johnson D, Moschos S, Lo R 2023 Nature Medicine Oncology, Immuno-oncology Highplex FL HALO
Single cell G-protein coupled receptor profiling of activated kidney fibroblasts expressing transcription factor 21 Kaur H, Yerra VG, Batchu SN, Tran DT, Kabir MDG, Liu Y, Advani SL, Sedrak P, Geldenhuys L, Tennankore KK, Poyah P, Siddiqi FS, Advani A 2023 British Journcal of Pharmacology Fibrosis Area Quantification HALO
Somatic mutation profiling, tumor-infiltrating leukocytes, tertiary lymphoid structures and PD-L1 protein expression in HER2-amplified colorectal cancer Liu X, Kou Z, Zhang H, Dong J, Zhang J, Peng Y, Ma S, Liang L, Meng X, Zhou Y, Yang J 2023 PeerJ Immuno-oncology Highplex FL HALO
Exploration of spatial heterogeneity of tumor microenvironment in nasopharyngeal carcinoma via transcriptional digital spatial profiling Wang L, Wang D, Zeng X, Zhang Q, Wu H, Liu J, Wang Y, Liu G, Poan Y 2023 International Journal of Biological Sciences Oncology Area Quantification, ISH-IHC/FISH-IF HALO
The role of human endometrial stem cells application in endometrial-factor induced infertility Bausyte R, Vaigauskaite B, Borutinskaite V, Valatkaite E, Besusparis J, Valkiuniene R, Kazenaite E, Ramasauskaite D, Navakauskiene R 2023 Research Square Other Area Quantification HALO
Signal-transducing adaptor protein 1 (STAP1) in microglia promotes the malignant progression of glioma Yang X, Ji C, Qi Y, Huang J, Hu L, Zhou Y, Zou L, Xia Y, Tan F, Yao Y, Chen D 2023 Research Square Oncology Highplex FL HALO
Intracranial injection of natural killer cells engineered with a HER2-targeted chimeric antigen receptor in patients with recurrent glioblastoma  Burger M, Forster M, Romanski A, Straßheimer F, Macas J, Zeiner P, Steidl E, Herkt S, Weber K, Schupp J, Lun J, Strecker M, Wlotzka K, Cakmak P, Opitz C, George R, Mildenberger I, Nowakowska P, Zhang C, Röder J, Müller E, Ihrig K, Langen K, Rieger M, Herrmann E, Bonig H, Harter P, Reiss Y, Hattingen E, Rödel F, Plate K, Tonn T, Senft C, Steinbach J, Wels W 2023 Neuro-Oncology Immuno-oncology Highplex FL HALO
Microglial depletion does not impact alphasynuclein aggregation or nigrostriatal degeneration in the rat preformed fibril model Stoll A, Kemp C, Patterson J, Kubik M, Kuhn N, Benskey M, Duffy M, Luk K, Sortwell C 2023 Research Square Neuroscience Area Quantification HALO
Host, reproductive, and lifestyle factors in relation to quantitative histologic metrics of the normal breast Abubakar M, Klein A, Fan S, Lawrence S, Mutreja K, Henry J, Pfeiffer R, Duggan M, Gierach G 2023 Research Square Oncology Classifier HALO, HALO Link
Spatial metabolomics reveals glycogen as an actionable target for pulmonary fibrosis Conroy L, Clarke H, Allison D, Valenca S, Sun Q, Hawkinson T, Young L, Ferreira J, Hammonds A, Dunne J, McDonald R, Absher K, Dong B, Bruntz R, Markussen K, Juras J, Alilain W, Liu J, Gentry M, Angel P, Waters C, Sun R 2023 Nature Communications Fibrosis Multiplex IHC, Highplex FL HALO
Induction of cancer neoantigens facilitates development of clinically relevant models for the study of pancreatic cancer immunobiology Panni U, Chen M, Zhang F, Cullinan D, Li L, James C, Zhang X, Rogers S, Alarcon A, Baer JM, Zhang D, Gao F, Miller CA, Gong Q, Lim KH, DeNardo DG, Goedegebuure SP, Gillanders WE, and Hawkins WG 2023 Cancer Immunology, Immunotherapy Immuno-oncology Multiplex IHC HALO
Oncolytic DNX-2401 virotherapy plus pembrolizumab in recurrent glioblastoma: a phase 1/2 trial Nassiri F, Patil V, Yefet L, Singh O, Liu J, Dang R, Yamaguchi T, Daras M, Cloughesy T, Colman H, Kumthekar P, Chen C, Aiken R, Groves M, Ong S, Ramakrishna R, Vogelbaum M, Khagi S, Kaley T, Melear J, Peereboom D, Rodriguez A, Yankelevich M, Nair S, Puduvalli V, Aldape K, Gao A, López-Janeiro Á, de Andrea C, Alonso M, Boutros P, Robbins J, Mason W, Sonabend A, Stupp R, Fueyo J, Gomez-Manzano C, Lang F, Zadeh G 2023 Nature Medicine Immuno-oncology Multiplex IHC HALO
Spatial analysis with SPIAT and spaSim to characterize and simulate tissue microenvironments Feng Y, Yang T, Zhu J, Li M, Doyle M, Ozcoban V, Bass G, Pizzolla A, Cain L, Weng S, Pasam A, Kocovski N, Huang Y, Keam S, Speed T, Neeson P, Pearson R, Sandhu S, Goode D, Trigos A 2023 Nature Communications Other Highplex FL HALO
Preclinical Evaluation of 9MW2821, a Site-Specific Monomethyl Auristatin E-based Antibody-Drug Conjugate for treatment of Nectin-4-expressing Cancers  Zhou W, Fang P, Yu D, Ren H, You M, Yin L, Mei F, Zhu H, Wang Z, Xu H, Cao Y, Sun X, Xu X, Bi J, Wang J, Ma L, Wang X, Chen L, Zhang Y, Cen X, Zhu X, Lou L, Liu D, Tan X, Yang J, Meng T, Shen J 2023 Molecular Cancer Therapeutics Oncology Multiplex IHC HALO
High expression ITGA2 affects the expression of MET,PD-L1, CD4 and CD8 with the immune microenvironment in pancreatic cancer patients Jin L, Duan Y, Li Z, Hu J, Shi H, Su Z, Li Z, Du B, Chen Y, Tan Y 2023 Research Square Oncology Highplex FL HALO
Outdoor air pollution and histologic composition of normal breast tissue Ish J, Abubakar M, Fan S, Jones R, Niehoff N, Henry J, Gierach G, White A 2023 Environment International Oncology Classifier HALO
Tumor-derived semaphorin 4A improves PD-1–blocking antibody efficacy by enhancing CD8+ T cell cytotoxicity and proliferation NAITO Y, KOYAMA S, MASUHIRO K, HIRAI T, UENAMI T, INOUE T, OSA A, MACHIYAMA H, WATANABE G, SAX N, VILLA J, KINUGASA-KATAYAMA Y, NOJIMA S, YAGA M, HOSONO Y, OKUZAKI D, SATOH S, TSUDA T, NAKANISHI Y, SUGA Y, MORITA T, FUKUSHIMA K, NISHIDE M, SHIROYAMA T, MIYAKE K, IWAHORI K, HIRATA H, NAGATOMO I, YANO Y, TAMIYA M, KUMAGAI T, TAKEMOTO N, INOHARA H, YAMASAKI S, YAMASHITA K, AOSHI T, AKBAY E, HOSEN N, SHINTANI Y, TAKAMATSU H, MORI M, TAKEDA Y, KUMANOGOH A 2023 Science Advances Immuno-oncology Multiplex IHC, Highplex FL HALO
Therapeutic effects of axitinib, an anti-angiogenic tyrosine kinase inhibitor, on interstitial cystitis Shin J, Ryu C, Yu H, Park Y, Shin D, Choo M 2023 Scientific Reports Other Area Quantification HALO
Tumor-infiltrating leukocyte profiling defines three immune subtypes of NSCLC with distinct signaling pathways and genetic alterations Aoki K, Nishito Y, Motoi N, Arai Y, Hiraoka N, Shibata T, Sonobe Y, Kayukawa Y, Hashimoto E, Takahashi M, Fujii E, Nishizawa T, Fukuda H, Ohashi K, Arai K, Mizoguchi Y, Yoshida Y, Watanabe S, Yamashita M, Kitano S, Sakamoto H, Nagata Y, Mitsumori R, Ozaki K, Niida S, Kanai Y, Hirayama A, Soga T, Maruyama T, Tsukada K, Yabuki N, Shimada M, Kitazawa T, Natori O, Sawada N, Kato A, Yoshida T, Yasuda K, Mizuno H, Tsunoda H, Ochiai A 2023 Cancer Research Communications Immuno-oncology Area Quantification, Cytonuclear HALO
SRF617 Is a Potent Inhibitor of CD39 with Immunomodulatory and Antitumor Properties  Warren M, Matissek S, Rausch M, Panduro M, Hall R, Dulak A, Brennan D, Das Yekkirala S, Koseoglu S, Masia R, Yang Y, Reddy N, Prenovitz R, Strand J, Zaidi T, Devereaux E, Jacoberger Foissac C, Stagg J, Lee B, Holland P, Palombella V, Lake A 2023 ImmunoHorizons Immuno-oncology Classifier, Area Quantification, Multiplex IHC HALO
Immunoscore immune checkpoint using spatial quantitative analysis of CD8 and PD-L1 markers is predictive of the efficacy of anti- PD1/PD-L1 immunotherapy in non-small cell lung cancer Ghiringhelli F, Bibeau F, Greillier L, Fumet J, Ilie A, Monville F, Laugé C, Catteau A, Boquet I, Majdi A, Morgand E, Oulkhouir Y, Brandone N, Adam J, Sbarrato T, Kassambara A, Fieschi J, Garcia S, Lepage A, Tomasini P, Galon J 2023 EBioMedicine Immuno-oncology Multiplex IHC, Spatial Analysis HALO
Pathologic, Immunologic, and Clinical Analysis of the Microsatellite Instability Phenotype in Endometrial Carcinoma Mackinnon Jr. A, Johnson C, Robin A, Christiansen L, Hanbazazh M, Summey R, Chandrashaker D, Harada S, Bradley W 2023 Human Pathology Oncology Cytonuclear HALO
Beta-containing bivalent SARS-CoV-2 protein vaccine elicits durable broad neutralization in macaques and protection in hamsters Berry C, Pavot V, Anosova N, Kishko M, Li L, Tibbitts T, Raillard A, Gautheron S, Cummings S, Bangari D, Kar S, Atyeo C, Deng Y, Alter G, Gutzeit C, Koutsoukos M, Chicz R, Lecouturier V 2023 Communications Medicine Infectious Disease Area Quantification HALO
Context-dependent activation of STING-interferon signaling by CD11b agonists enhances anti-tumor immunity Liu X, Hogg G, Zuo C, Borcherding N, Baer J, Lander V, Kang LI, Knolhoff B, Ahmad F, Osterhout R, Galkin A, Bruey J, Carter L, Mpoy C, Vij K, Fields R, Schwarz J, Park H, Gupta V, DeNardo D 2023 Cancer Cell Immuno-oncology Area Quantification, Cytonuclear HALO
Reciprocal Interaction of Cancer Stem Cells of Cholangiocarcinoma with Macrophage Wang X, Golino J, Hawk N, Xie C 2023 Stem Cell Reviews and Reports Oncology Area Quantification HALO
Early chronic suppression of microglial p38α in a model of Alzheimer’s disease does not significantly alter amyloid-associated neuropathology Braun D, Frazier H, Davis V, Coleman M, Rogers C, Van Eldik L 2023 PLOS One Neuroscience Object Colocalization HALO
Sequential pembrolizumab cooperates with platinum/5FU to remodel the tumor immune microenvironment in advanced gastric cancer: A phase II chemoimmunotherapy trial Klempner S, Lee J, Mehta A, An M, Min B, Heo Y, Parikh M, Bi L, Cristescu R, Lee H, Kim T, Lee S, Moon J, Park R, Strickland M, Park W, Kang W, Kim K, Kim S 2023 Research Square Immuno-oncology Classifier, Highplex FL HALO
An Fc-muted bispecific antibody targeting PD-L1 and 4-1BB induces antitumor immune activity in colorectal cancer without systemic toxicity Cheng L, Zhu M, Gao Y, Liu W, Yin W, Zhou P, Zhu Z, Niu L, Zeng X, Zhang D, Fang Q, Wang F, Zhao Q, Zhang Y, Shen G 2023 Cellular and Molecular Biology Letters Immuno-oncology Multiplex IHC, Highplex FL HALO
Clearance of senescent macrophages ameliorates tumorigenesis in KRAS-driven lung cancer Haston S, Gonzalez-Gualda E, Morsli S, Ge J, Reen V, Calderwood A, Moutsopoulos I, Panousopoulos L, Deletic P, Carreno G, Guiho R, Manshaei S, Gonzalez-Meljem J, Lim H, Simpson D, Birch J, Pallikonda H, Chandra T, Macias D, Doherty G, Rassl D, Rintoul R, Signore M, Mohorianu I, Akbar A, Gil J, Muñoz-Espín D, Martinez-Barbera J 2023 Cancer Cell Oncology Cytonuclear HALO
NLRP12-PANoptosome activates PANoptosis and pathology in response to heme and PAMPs Sundaram B, Pandian N, Mall R, Wang Y, Sarkar R, Kim H, Malireddi R, Karki R, Janke L, Vogel P, Kanneganti T 2023 Cell Immunology Classifier HALO
Mucin 4 is a cellular biomarker of necrotizing bronchiolitis in influenza A virus infection Arruda B, Kanefsky R, Hau S, Janzen G, Anderson T, Baker A 2023 Microbes and Infection Infectious Disease Area Quantification HALO
Quantitative intravital imaging for real-time monitoring of pancreatic tumor cell hypoxia and stroma in an orthotopic mouse model Samuel T, Rapic S, O'Brien C, Edson M, Zhong Y, DaCosta R 2023 Science Advances Oncology Registration HALO
PI3K inhibition circumvents resistance to SHP2 blockade in metastatic triple-negative breast cancer Amante RJ, Jehanno C, De Silva D, Coissieux M, Ackerknecht M, Romanet V, Sethi A, Hamelin B, Preca B, Piscuoglio S, Ng C, Mohseni M, Bentires-Alj M 2023 Journal of Mammary Gland Biology and Neoplasia Oncology Area Quantification HALO
CNS-dominant human FMRP isoform rescues seizures, fear, and sleep abnormalities in Fmr1-KO mice Wong H, Hooper A, Kang H, Lee S, Zhao J, Sadhu C, Rawat S, Gray S, Hampson D 2023 JCI Insight Neuroscience Area Quantification HALO
Epitope Lability of Phosphorylated Biomarkers of the DNA Damage Response Pathway Results in Increased Vulnerability to Effects of Delayed or Incomplete Formalin Fixation Wiseman E, Moss J, Atkinson J, Baakza H, Hayes E, Willis S, Waring P, Canales J, Jones G 2023 Journal of Histochemistry & Cytochemistry Other Classifier, Cytonuclear, Spatial Analysis HALO
D-serine availability modulates prefrontal cortex inhibitory interneuron development and circuit maturation Folorunso O, Brown S, Baruah J, Harvey T, Jami S, Radzishevsky I, Wolosker H, McNally J, Gray J, Vasudevan A, Balu D 2023 Scientific Reports Neuroscience ISH HALO
Defective extracellular matrix remodeling in brown adipose tissue is associated with fibro-inflammation and reduced diet-induced thermogenesis Pellegrinelli V, Figueroa-Juárez E, Samuelson I, U-Din M, Rodriguez-Fdez S, Virtue S, Leggat J, Çubuk C, Peirce V, Niemi T, Campbell M, Rodriguez-Cuenca S, Dopazo Blázquez J, Carobbio S, Virtanen K, Vidal-Puig A 2023 Cell Reports Metabolism Classifier, Area Quantification, Vacuole HALO
Orthotopic model of pancreatic cancer using CD34+ humanized mice and generation of tumor organoids from humanized tumors Jeong J, Park S, Lee S, Kim Y, Shim I, Jeong S, Choi E, Kim J, Jun E 2023 International Immunopharmacology Immuno-oncology Area Quantification HALO
Kv7/KCNQ potassium channels in cortical hyperexcitability and juvenile seizure-related death in Ank2-mutant mice Oh H, Lee S, Oh Y, Kim S, Kim Y, Yang Y, Choi W, Yoo Y, Cho H, Lee S, Yang E, Koh W, Won W, Kim R, Lee C, Kim H, Kang H, Kim J, Ku T, Paik S, Kim E 2023 Nature Communications Neuroscience FISH HALO
Soluble CD4 effectively prevents excessive TLR activation of resident macrophages in the onset of sepsis Zhang S, Xu Q, Shi L, Li S, Wang W, Wang Q, Lu L, Xiao H, Wang J, Li F, Liang Y, Gong S, Peng H, Zhang Z, Tang G 2023 Signal Transduction and Targeted Therapy Immunology Highplex FL HALO
Activation of IGFBP4 via unconventional mechanism of miRNA attenuates metastasis of intrahepatic cholangiocarcinoma Tao L, Wang Y, Shen Z, Cai J, Zheng J, Xia S, Lin Z, Wan Z, Qi H, Jin R, Wang L, Xu J, Liang X 2023 Hepatology International Oncology Highplex FL HALO
The Effects of Acute Ethanol Intoxication on Spinal Cord Injury Outcomes in Female Mice Glaser E, Stewart A, Jagielo-Miller J, Bailey C, Prendergast M, Gensel J 2023 Journal of Neurotrauma Neuroscience Area Quantification HALO
The Hippo-YAP signaling pathway drives CD24- mediated immune evasion in esophageal squamous cell carcinoma via macrophage phagocytosis Yan Z, Hou J, Zhang L, Chen Z, Gao C, Ahmad N, Guo M, Wang W, Han T, Chang T, Kang X, Wang L, Liang Y, Li X, Zhou X 2023 Research Square Immuno-oncology Spatial Analysis HALO
Type III interferon inhibits bladder cancer progression by reprogramming macrophage-mediated phagocytosis and orchestrating effective immune responses Wang B, Zhou B, Chen J, Sun X, Yang W, Yang T, Yu H, Chen P, Chen K, Huang X, Fan X, He W, Huang J, Lin T 2023 Research Square Immuno-oncology Multiplex IHC HALO, HALO AI
Characterization of intratumoral tertiary lymphoid structures in pancreatic ductal adenocarcinoma: cellular properties and prognostic significance Zou X, Lin X, Cheng H, Chen Y, Wang R, Ma M, Liu Y, Dai Z, Tasiheng Y, Yan Y, Hou Q, Ding F, Chen H, Yu X, Wang X, Liu C 2023 Journal for ImmunoTherapy of Cancer Immuno-oncology Highplex FL HALO, HALO AI
Detection of virus in colorectal cancer and the tumor immune microenvironment in EBV-associated colorectal cancer Lv D, Zuo Y, Bibi A, Meng T, Xu Y 2023 Research Square Oncology, Infectious Disease Multiplex IHC HALO
Effects of a long-acting secretin peptide analog alone and in combination with a GLP-1R agonist in a diet-induced obesity mouse model Loeffler M, Klepac K, Baljuls A, Hamilton B, Mayer-Wrangowski S, Haebel P, Zimmermann T 2023 Molecular Metabolism Metabolism Multiplex IHC HALO
Trackable Intratumor Microdosing and Spatial Profiling Provide Early Insights into Activity of Investigational Agents in the Intact Tumor Microenvironment Derry J, Burns C, Frazier J, Beirne E, Grenley M, DuFort C, Killingbeck E, Leon M, Williams C, Gregory M, Houlton J, Clayburgh D, Swiecicki P, Huszar D, Berger A, Klinghoffer R 2023 Cellular and Molecular Biology Letters Oncology Highplex FL HALO, HALO AI
Endosomal Escape Vehicle Platform Enhances the Delivery of Oligonucleotides in Preclinical Models of Neuromuscular Disorders Li X, Kheirabadi M, Dougherty P, Kamer K, Shen X, Estrella N, Peddigari S, Pathak A, Blake S, Sizensky E, del Genio C, Gaur A, Dhanabal M, Girgenrath M, Sethuraman N, Qian Z 2023 Molecular Therapy: Nucleic Acid Neuroscience Multiplex IHC HALO
Modifying antibody-FcRn interactions to increase the transport of antibodies through the blood-brain barrier Tien J, Leonoudakis D, Petrova R, Trinh V, Taura T, Sengupta D, Jo L, Sho A, Yun Y, Doan E, Jamin A, Hallak H, Wilson D, Stratton J 2023 mABS Neuroscience Classifier, Area Quantification, Object Colocalization HALO
The antiviral effects of a MEK1/2 inhibitor promote tumor regression in a preclinical model of human papillomavirus infection-induced tumorigenesis Luna A, Young J, Sterk R, Bondu V, Schultz F, Kusewitt D, Kang H, Ozbun M 2023 Antiviral Research Oncology, Infectious Disease Classifier, Area Quantification, Cytonuclear HALO
A cellular and molecular spatial atlas of dystrophic muscle Stec M, Su Q, Adler C, Zhang L, Golann D, Khan N, Panagis L, Villalta S, Ni M, Wei Y, Walls J, Murphy A, Yancopoulos G, Atwal G, Kleiner S, Halasz G, Sleeman M 2023 Proceedings of the National Academy of Sciences Myology ISH/FISH, Highplex FL HALO
Genome-wide mapping of cancer dependency genes and genetic modifiers of chemotherapy in high-risk hepatoblastoma Fang J, Singh S, Cheng C, Natarajan S, Sheppard H, Abu-Zaid A, Durbin A, Lee H, Wu Q, Steele J, Connelly J, Jin H, Chen W, Fan Y, Pruett-Miller S, Rehg J, Koo S, Santiago T, Emmons J, Cairo S, Wang R, Glazer E, Murphy A, Chen T, Davidoff A, Armengol C, Easton J, Chen X, Yang J 2023 Nature Communications Oncology Classifier HALO
Stem cell-like T cell depletion in the recurrent head and neck cancer immune microenvironment Chen L, Lee N, Sarkar R, Katabi N, Li Y, Morris L, Wong R, Sherman E, Reis-Filho J, Hollmann T, Riaz N 2023 OncoImmunology Immuno-oncology Spatial Analysis, Highplex FL HALO
TSLP/dendritic cell axis promotes CD4+ T cell tolerance to the gut microbiome Messerschmidt J, Azin M, Dempsey K, Demehri S 2023 JCI Insight Immunology Highplex FL HALO
The Defenders of the Alveolus Succumb in COVID-19 Pneumonia to SARS-CoV-2 and Necroptosis, Pyroptosis and Panoptosis Schifanella L, Anderson J, Wieking G, Southern P, Antinori S, Galli M, Corbellino M, Lai A, Klatt N, Schacker T, Haase A 2023 The Journal of Infectious Disease Infectious Disease Area Quantification HALO
Poor outcome in postpartum breast cancer patients is associated with distinct molecular and immunological features Lefrère H, Moore K, Floris G, Sanders J, Seignette I, Bismeijer T, Peters D, Broeks A, Hooijberg E, Van Calsteren K, Neven P, Warner E, Peccatori F, Loibl S, Maggen C, Han S, Jerzak K, Annibali D, Lambrechts D, de Visser K, Wessels L, Lenaerts L, Amant F 2023 Clinical Cancer Research Oncology Classifier, Highplex FL HALO, HALO AI
Endocrine therapy synergizes with SMAC mimetics to potentiate antigen presentation and tumor regression in hormone receptor-positive breast cancer  Hermida-Prado F, Xie Y, Sherman S, Nagy Z, Russo D, Akhshi T, Chu Z, Feit A, Campisi M, Chen M, Nardone A, Guarducci C, Lim K, Font-Tello A, Lee I, García-Pedrero J, Canadas I, Agudo J, Huang Y, Sella T, Jin Q, Tayob N, Mittendorf E, Tolaney S, Qiu X, Long H, Symmans W, Lin J, Santagata S, Bedrosian I, Yardley D, Mayer I, Richardson E, Oliveira G, Wu C, Schuster E, Dowsett M, Welm A, Barbie D, Metzger O, Jeselsohn R 2023 Cancer Research Oncology Multiplex IHC HALO
Localization of unlabelled bepirovirsen antisense oligonucleotide in murine tissues using in situ hybridization and CARS imaging Spencer-Dene B, Mukherjee P, Alex A, Bera K, Tseng W, Shi J, Chaney E, Spillman Jr. D, Marjanovic B, Miranda E, Boppart S, Hood S 2023 RNA Other ISH HALO, HALO AI
Differential expression of CD8 defines phenotypically distinct cytotoxic T cells in cancer and multiple sclerosis Burkard T, Herrero San Juan M, Dreis C, Kiprina A, Namgaladze D, Siebenbrodt K, Luger S, Foerch C, Pfeilschifter J, Weigert A, Radeke H 2023 Clinical and Translational Medicine Oncology, immunology Classifier, Spatial Analysis, Highplex FL, TMA HALO
Histological validation of atrial structural remodelling in patients with atrial fibrillation Takahashi Y, Yamaguchi T, Otsubo T, Nakashima K, Shinzato K, Osako R, Shichida S, Kawano Y, Fukui A, Kawaguchi A, Aishima S, Saito T, Takahashi N, Node K 2023 European Heart Journal Other Area Quantification HALO
An intestinal Th17 subset is associated with inflammation in Crohn’s Disease and activated by adherent-invasive Escherichia coli (AIEC) Paroni M, Leccese G, Ranzani V, Moschetti G, Chiara M, Perillo F, Ferri S, Clemente F, Noviello D, Conforti FS, Ferrero S, Karnani B, Bosotti R, Vasco C, Curti S, Crosti MC, Gruarin P, Rossetti G, Conte MP, Vecchi M, Pagani M, Landini P, Facciotti F, Abrignani S, Caprioli F, Geginat J 2023 Journal of Crohn's and Colitis Immunology Highplex FL HALO
Decreased left heart flow in fetal lambs causes left heart hypoplasia and pro-fibrotic tissue remodeling Reuter MS, Sokolowski DJ, Diaz-Mejia JJ, Keunen J, de Vrijer B, Chan C, Wang L, Ryan G, Chiasson DA, Ketela T, Scherer SW, Wilson MD, Jaeggi E, and Chaturvedi RR 2023 Communications Biology Other Area Quantification HALO
Long-Term Dysfunction of Taste Papillae in SARS-CoV-2 Yao Q, Doyle M, Liu Q, Appleton A, O'Connell J, Weng N, Egan J 2023 NEJM Evidence Infectious Disease FISH HALO
Unbiased differential proteomic profiling between cancerassociated fibroblasts and cancer cell lines Lau R, Yu L, Roumeliotis T, Stewart A, Pickard L, Riisanes R, Gurel B, de Bono J, Choudhary J, Banerji U 2023 Journal of Proteomics Oncology Multiplex IHC HALO
Single-cell characterization of pulmonary nodules implicates suppression of immunosurveillance across early stages of lung adenocarcinoma Yanagawa J, Tran L, Salehi-Rad R, Lim R, Dumitras C, Fung E, Wallace W, Prosper A, Fishbein G, Shea C, Hong R, Kahangi B, Deng J, Gower A, Liu B, Campbell J, Mazzilli S, Beane J, Kadara H, Lenburg M, Spira A, Aberle D, Krysan K, Dubinett S 2023 Cancer Research Immuno-oncology Highplex FL HALO
The CD73 is induced by TGF-β1 triggered by nutrient deprivation and highly expressed in dedifferentiated human melanoma Giraulo C, Turiello R, Orlando L, Leonardelli S, Landsberg J, Belvedere R, Rolshoven G, Muller C, Holzel M, Morello S 2023 Biomedicine & Pharmacotherapy Oncology Highplex FL, TMA HALO, HALO AI
Absence of sympathetic innervation hampers the generation of tertiary lymphoid structures upon acute lung inflammation Riffard C, Letaïef L, Azar S, Casrouge A, Brunet I, Teillaud JL, Dieu-Nosjean MC 2023 Research Square Immunology Multiplex IHC HALO, HALO AI
Multiplex Immunohistochemistry and Immunofluorescence: A Practical Update for Pathologists Harms P, Frankel T, Moutafi M, Rao A, Rimm D, Taube J, Thomas D, Chang M, Pantanowitz L 2023 Modern Pathology Review Spatial Analysis, Highplex FL HALO
An international multi-institutional validation study of the algorithm for prostate cancer detection and Gleason grading Tolkach Y, Ovtcharov V, Pryalukhin A, Eich ML, Gaisa NT, Braun M, Radzhabov A, Quaas A, Hammerer P, Dellmann A, Hulla W, Haffner MC, Reis H, Fahoum I, Samarska I, Borbat A, Pham H, Heidenreich A, Klein S, Netto G, Caie P, Buettner R 2023 Precision Oncology Oncology HALO, HALO AI
GREB1 isoform 4 is specifically transcribed by MITF and required for melanoma proliferation Shinzawa K, Matsumoto S, Sada R, Harada A, Saitoh K, Kato K, Ikeda S, Hirayama A, Yokoi K, Tanemura A, Nimura K, Ikawa M, Soga T, Kikuchi A 2023 Oncogene Oncology Multiplex IHC HALO
Atorvastatin rescues hyperhomocysteinemia-induced cognitive deficits and neuroinflammatory gene changes Weekman E, Johnson S, Rogers C, Sudduth T, Xie K, Qiao Q, Fardo D, Bottiglieri T, Wilcock D 2023 Journal of Neuroinflammation Neuroscience Object Colocalization HALO
Intratumoral Heterogeneity of Ki67 Proliferation Index Outperforms Conventional Prognostic Factors in Hormone Receptor-Positive Breast Cancer Zilenaite-Petrulaitiene D, Rasmusson A, Besusparis J, Valkiuniene R, Augulis R, Laurinaviciene A, Plancoulaine B, Petkevicius L, Laurinavicius A 2023 Research Square Oncology Multiplex IHC, Figure Maker HALO, HALO AI
Electrical impedance myography detects dystrophin-related muscle changes in mdx mice Hiyoshi T, Zhao F, Baba R, Hirakawa T, Kuboki R, Suzuki K, Tomimatsu Y, O'Donnell P, Han S, Zach N, Nakashima M 2023 Research Square Myology Area Quantification, Muscle Fiber HALO
Low molecular weight heparin synergistically enhances the efficacy of adoptive and anti-PD-1-based immunotherapy by increasing lymphocyte infiltration in colorectal cancer Quan Y, He J, Zou Q, Zhang L, Sun Q, Huang H, Li W, Xie K, Wie F 2023 Journal for ImmunoTherapy of Cancer Immuno-oncology Classifier, Multiplex IHC, Highplex FL HALO
Immune checkpoint blockade induces distinct alterations in the microenvironments of primary and metastatic brain tumors Sun L, Kienzler JC, Reynoso JG, Lee A, Shiuan E, Li S, Kim J, Ding L, Monteleone AJ, Owens GC, Phillips JJ, Everson RG, Nathanson D, Cloughesy TF, Li G, Liau LM, Hugo W, Kim W, Prins RM 2023 Journal of Clinical Investigation Immuno-oncology Highplex FL HALO
Altered expression, but small contribution, of the histone demethylase KDM6A in obstructive uropathy in mice Hong LYQ, Yeung ESH, Tran DT, Yerra VGY, Kaur HK, Kabir MDG, Advani SL, Liu Y, Batchu SN, Advani A 2023 Disease Models & Mechanisms Gastroenterology Area Quantification, Object Colocalization HALO
Integrative multi-omics reveals two biologically distinct groups of pilocytic astrocytoma Picard D, Felsberg J, Langini M, Stachura P, Qin N, Macas J, Reiss Y, Bartl J, Selt F, Sigaud R, Meyer FD, Stefanski A, Stühler K, Roque L, Roque R, Pandyra AA, Brozou T, Knobbe-Thomsen C, Plate KH, Roesch A, Milde T, Reifenberger G, Leprivier G, Faria CC, Remke M 2023 Acta Neuropathologica Oncology Highplex FL HALO
Irreversible cell cycle exit associated with senescence is mediated by constitutive MYC degradation Afifi M, Crncec A, Cornwell J, Cataisson C, Paul D, Ghorab L, Hernandez M, Wong M, Kedei N, Cappell S 2023 Cell Reports Other Cytonuclear HALO, HALO AI
Neoadjuvant palbociclib plus either giredestrant or anastrozole in oestrogen receptor-positive, HER2-negative, early breast cancer (coopERA Breast Cancer): an open-label, randomised, controlled, phase 2 study Hurvitz SA, Bardia A, Quiroga V, Park YH, Blancas I, Alonso-Romero JL, Vasiliev A, Adamchuk H, Salgado M, Yardley DA, Berzoy O, Zamora-Auñón P, Chan D, Spera G, Xue C, Ferreira E, Badovinac Crnjevic T, Pérez-Moreno PD, López-Valverde V, Steinseifer J, Fernando TM, Moore HM, Fasching PA, on behalf of the coopERA Breast Cancer study group 2023 The Lancet Oncology Oncology Multiplex IHC HALO
Amyloid-β (Aβ) immunotherapy induced microhemorrhages are associated with activated perivascular macrophages and peripheral monocyte recruitment in Alzheimer’s disease mice Taylor X, Clark I, Fitzgerald G, Oluoch H, Hole J, DeMattos R, Wang Y, Pan F 2023 Molecular Neurodegeneration Immuno-oncology, Neuroscience Area Quantification HALO
MYC is a clinically significant driver of mTOR inhibitor resistance in breast cancer Bhin J, Yemelyanenko J, Chao X, Klarenbeek S, Opdam M, Malka Y, Hoekman L, Kruger D, Bleijerveld O, Brambillasca CS, Sprengers J, Siteur B, Annunziato S, van Haren MJ, Martin NI, van de Ven M, Peters D, Agami R, Linn SC, Boven E, Altelaar M, Jonkers J, Zingg D, Wessels LFA 2023 Journal of Experimental Medicine Oncology Multiplex IHC HALO
Pan-Cancer Analysis Revealed ITM2A as a Predictive Biomarker of Prognosis and Immunotherapy for Kidney Renal Clear Cell Carcinoma Zhang H, Fang J, Ruan R, Yu J, Wang S 2023 Research Square Oncology Multiplex IHC HALO
Pathologist-Trained Machine Learning Classifiers Developed to Quantitate Celiac Disease Features Differentiate Endoscopic Biopsies According to Modified Marsh Score and Dietary Intervention Response Gruver A, Lu H, Zhao X, Fulford A, Soper M, Ballard D, Hanson J, Schade A, His E, Gottlieb K. Credille K 2023 Research Square Gastroenterology Multiplex IHC HALO, HALO AI
LINC01638 Sustains Human Mesenchymal Stem Cell Self-Renewal and Competency for Osteogenic Cell Fate Gordon J, Tye C, Banerjee B, Ghule P, Wijnen A, Kabala F, Page N, Falcone M, Stein J, Stein G, Lian J 2023 Research Square Other Object Colocalization, FISH HALO
Driver gene combinations dictate cutaneous squamous cell carcinoma disease continuum progression Bailey P, Ridgway RA, Cammareri P, Treanor-Taylor M, Bailey UM, Schoenherr C, Bone M, Schreyer D, Purdie K, Thomson J, Rickaby W, Jackstadt R, Campbell AD, Dimonitsas E, Stratigos AJ, Arron ST, Wang J, Blyth K, Proby CM, Harwood CA, Sansom OJ, Leigh IM, and Inman GJ 2023 Nature Communications Oncology Cytonuclear HALO
Integration of peripheral blood- and tissue-based biomarkers of response to immune checkpoint blockade in urothelial carcinoma Vanguri RS, Smithy JW, Li Y, Zhuang M, Maher CA, Aleynick N, Peng X, Al-Ahmadie H, Funt SA, Rosenberg JE, Iyer G, Bajorin D, Mathews JC, Nadeem S, Panageas KS, Shen R, Callahan MK, Hollmann TJ 2023 Journal of Pathology Immuno-oncology Highplex FL HALO, HALO AI
Desialylated platelet clearance in the liver is a novel mechanism of systemic immunosuppression Li J, Karakas D, Xue F, Chen Y, Zhu G, Ycel Y, MacParland S, Zhang H, Semple J, Freedman J, Shi Q, Ni H 2023 Research Immunology Area Quantification HALO
Fibroblast inhibition by tocilizumab enabled gemcitabine/nab-paclitaxel rechallenge for pancreatic cancer Mitsunaga S, Ikeda M, Imaoka H, Sasaki M, Watanabe K, Sato A, Aoki K, Ochiai A, Makakawa M, Nishidate M, Yamaguchi K Terao K, Sawada N, Fujitomo T, Fujii E, Kato A, Tsunoda H 2023 Cancer Science Immuno-oncology Cytonuclear HALO
SMRT Sequencing Enables High-Throughput Identification of Novel AAVs from Capsid Shuffling and Directed Evolution Widler Casy, Garza IT, Chen X, Dong T, Hu Y, Kanchwala M, Trygg CB, Shyng C, Xing C, Bunnell BA, Braun SE, Gray SJ 2023 Genes Other Area Quantification HALO
Differential effects of PGAM5 knockout on high fat high fructose diet and methionine choline-deficient diet induced non-alcoholic steatohepatitis (NASH) in mice Li L, Guo C, Yu Y, Tie L, Lu G, Liu F, Han X, Ji L, Zou X 2023 Cell & Bioscience Metabolism Area Quantification, Multiplex IHC HALO
A pan-cancer single-cell panorama of human natural killer cells Tang F, Li J, Qi L, Liu D, Bo Y, Qin S, Miao Y, Yu K, Hou W, Li J, Peng J, Tian Z, Zhu L, Peng H, Wang D, Zhang Z 2023 Cell Immuno-oncology Highplex FL HALO
Distinct Patterns of Hippocampal Pathology in Alzheimer's Disease with Transactive Response DNA-binding Protein 43 Minogue G, Kawles A, Zouridakis A, Keszycki R, Macomber A, Lubbat V, Gill N, Mao Q, Flanagan ME, Zhang H, Castellani R, Bigio EH, Mesulam M-M, Geula C, Gefen T 2023 Annals of Neurology Neuroscience Object Colocalization HALO
Rosmarinic acid alleviates intestinal inflammatory damage and inhibits endoplasmic reticulum stress and smooth muscle contraction abnormalities in intestinal tissues by regulating gut microbiota Li K, Wu J, Xu S, Li X, Zhang Y, Gao X 2023 Microbiology Spectrum Infectious Disease Area Quantification HALO
Neighboring macrophage-induced alteration in the phenotype of colorectal cancer cells in the tumor budding area Kawamura I, Ohe R, Suzuki K, Kabasawa T, Kitoaka T, Takahara D, Kono M, Uchiyama N, Musha H, Futakuchi M, Motoi F 2023 Research Square Immuno-oncology Multiplex IHC, Spatial Analysis HALO
Evaluation of the efficacy of Abelmoschus manihot (L.) on diabetic nephropathy by analyzing biomarkers in the glomeruli and proximal and distal convoluted tubules of the kidneys Yu H, Wang M, Yu J, Tang H, Xu Q, Cheng N, Luo X, Wang Y, Ge H, Qiang L, Tang W, Gu H 2023 Frontiers in Pharmacology Gastroenterology Multiplex IHC HALO
Immune response after pig-to-human kidney xenotransplantation: a multimodal phenotyping study Loupy A, Goutaudier V, Giarraputo A, Mezine F, Morgand E, Robin B, Khalil K, Mehta S, Keating B, Dandro A, Certain A, Tharaux PL, Narula N, Tissier R, Giraud S, Hauet T, Pass HI, Sannier A, Wu M, Griesemer A, Ayares D, Tatapudi V, Stern J, Lefaucheur C, Bruneval P, Mangiola M, Montgomery RA 2023 The Lancet Immunology Multiplex IHC HALO, HALO AI
Effects of the purified dry extract of fermented ginseng BST204 on muscle fiber regeneration Jo S, Park Y, Chang Y, Moon J, Lee S, Lee H, Kim M, Kim D, Bae S, Park S, Yun H, You J, Im M, Han H, Kim S, Jin D 2023 Biochemistry and Biophysics Reports Myology Muscle Fiber HALO
Single-cell profiling uncovers a Muc4-expressing metaplastic gastric cell type sustained by Helicobacter pylori-driven inflammation O'Brien VP, Kang Y, Shenoy MK, Finak G, Young WC, Dubrulle J, Koch L, Rodriguez Martinez AE, Williams J, Donato E, Batra SK, Yeung CCS, Grady WM, Koch MA, Gottardo R, Salama NR 2023 Cancer Research Communications Oncology, Infectious Disease Highplex FL HALO
A novel 4-1BB/HER2 bispecific antibody shows potent antitumor activities by increasing and activating tumor-infiltrating T cells Shen A, Liu W, Wang H, Zeng X, Wang M, Zhang D, Zhao Q, Fang Q, Wang F, Cheng L, Shen G, Li Y 2023 American Journal of Cancer Research Immuno-oncology Multiplex IHC HALO
Combining the AKT inhibitor capivasertib and SERD fulvestrant is effective in palbociclib-resistant ER+ breast cancer preclinical models Hopcroft L, Wigmore EM, Williamson SC, Ros S, Eberlein C, Moss JI, Urosevic J, Carnevalli LS, Talbot S, Bradshaw L, Blaker C, Gunda S, Owenson V, Hoffmann S, Sutton D, Jones S, Goodwin RJAG, Willis BS, Rooney C, DeBruin E, Barry ST 2023 npj Breast Cancer Oncology Multiplex IHC HALO, HALO AI
Macrophage reprogramming—rather than depletion —is efficacious in a specific subset of colorectal tumor models Mohamed N, Amirkhah R, Lavaud X, Gilroy K, Bartolini R, Mulholland E, Garg A, Pennel K, Jackstadt R, Ridgway R, Nixon C, Hatthakarnku P, Campbell A, Leedham S, Edwards J, Dunne P, Barry S, Graham G, Sansom O 2023 Research Square Immuno-oncology Multiplex IHC, Highplex FL HALO
Proteogenomic analysis of chemo-refractory highgrade serous ovarian cancer Chowdhury S, Kennedy JJ, Ivey RG, Murillo OD, Hosseini N, Song X, Petralia F, Calinawan A, Savage SR, Berry AB, Reva B, Ozbek U, Krek A, Ma W, Leprevost FdV, Ji J, Yoo S, Lin C, Voytovich UJ, Huang Y, Lee SH, Bergan L, Lorentzen TD, Mesri M, Rodriguez H, Hoofnagle AN, Herbert ZT, Nesvizhskii AI, Zhang B, Whiteaker JR, Fenyo D, McKerrow W, Wang J, Schürer SC, Stathias V, Chen XS, Barcellos-Hoff MH, Starr TK, Winterhoff BJ, Nelson AC, Mok SC, Kaufmann SH, Drescher C, Cieslik M, Wang P, Birrer MJ, Paulovich AG 2023 Cell Oncology Highplex FL HALO, HALO Link
Early Detection of Genotoxic Hepatocarcinogens in Rats Using γH2AX and Ki-67: Prediction by Machine Learning Michiba A, Gi M, Yokohira M, Sakurai E, Teramoto A, Kiriyama Y, Yamada S, Wanibuchi H, Tsukamoto T 2023 Toxicological Sciences Oncology Multiplex IHC, Highplex FL HALO
Netrin-1 blockade inhibits tumour growth and EMT features in endometrial cancer Cassier PA, Navaridas R, Bellina M, Rama N, Ducarouge B, Hernandez-Vargas H, Delord JP, Lengrand J, Paradisi A, Fattet L, Garin G, Gheit H, Dalban C, Pastushenko I, Neves D, Jelin R, Gadot N, Braissand N, Léon S, Degletagne C, Matias-Guiu X, Devouassoux-Shisheboran M, Mery-Lamarche EM, Allard J, Zindy E, Decaestecker C, Salmon I, Perol D, Dolcet X, Ray-Coquard I, Blanpain C, Bernet A, Mehlen P 2023 Nature Oncology Multiplex IHC HALO
Regulation of antigen-specific T cell infiltration and spatial architecture in multiple myeloma and premalignancy Robinson MH, Villa NY, Jaye DL, Nooka AK, Duffy A, McCachren SS, Manalo J, Switchenko JM, Barnes S, Potdar S, Azeem MI, Horvat AA, Parihar VC, Gong J, Liang Y, Smith GH, Gupta VA, Boise LH, Kaufman JL, Hofmeister CC, Joseph NS, Lonial S, Dhodapkar KM, Dhodapkar MV 2023 Journal of Clinical Investigation Immuno-oncology Highplex FL HALO
HIF-1 regulates pathogenic cytotoxic T cells in lupus skin disease Little A, Chen P, Vesely M, Khan R, Fiedler J, Garritano J, Maisha F, McNiff J, Craft J 2023 JCI Insight Immunology, Dermatology FISH-IF HALO, HALO AI
ATR-binding lncRNA ScaRNA2 promotes cancer resistance through facilitating efficient DNA end resection during homologous recombination repair Chen Y, Shen H, Liu T, Cao K, Wan Z, Du Z, Wang H, Yu Y, Ma S, Lu E, Zhang W, Cai J, Gao F, Yang Y 2023 Journal of Experimental & Clinical Cancer Research Oncology Highplex FL, TMA HALO
Feasibility and Impact of Immunohistochemistry-based Molecular Subtyping for Muscle-invasive Bladder Cancer in Patients Treated with Radiation-based Therapy Hesswani C, Jackson CL, Marcq G, Hardy C, Kool R, Mansure JJ, Brimo F, Berman DM, Kassouf W 2023 European Urology Open Science Oncology Multiplex IHC HALO
Skeletal phenotype amelioration in Mucopolysaccharidosis VI requires intervention at the earliest stages of postnatal development Hwang-Wong E, Amar G, Das N, Zhang X, Aaron N, Gale K, Rothman N, Fante M, Baik A, Bhargava A, Fricker A, McAlister M, Rabinowitz J, Lees-Shepard J, Nannuru K, Economides AN, Cygnar KD 2023 JCI Insight Other Vacuole, Layer Thickness HALO
Combined toxic effects of MWCNTs and ZnO nanoparticle on the liver of common carp Gao X, Huang Y, Ren H, Li Y, Chen J, Xu R 2023 Research Square Toxicology Highplex FL HALO
Investigating the Effects of Stereotactic Body Radiation Therapy on Pancreatic Tumor Hypoxia and Microvasculature in an Orthotopic Mouse Model using Intravital Fluorescence Microscopy Samuel T, Rapic S, Lindsay P, DaCosta RS 2023 Research Square Oncology Classifier, Area Quantification HALO
A TIAM1- TRIM28 complex mediates epigenetic silencing of protocadherins to promote migration of lung cancer cells Ginn L, Maltas J, Baker MJ, Chaturvedi A, Wilson L, Guilbert R, Amaral FMR, Priest L, Mole H, Blackhall F, Diamantopoulou Z, Somervaille TCP, Hurlstone A, Mallairi A 2023 Proceedings of the National Academy of Sciences Oncology Multiplex IHC HALO
GRK2 inhibits Flt-1+ macrophage infiltration and its proangiogenic properties in rheumatoid arthritis Yang X, Zhao Y, Wei Q, Zhu X, Wang L, Zhang W, Liu X, Kuai J, Wang F, Wei W 2023 Acta Pharmacologica Sinica B Immunology Highplex FL HALO
Perspectives for immunotherapy of EBV-associated GLELC: A relatively “hot” tumor microenvironment Lei Y, Cao P, Zheng X, Wi J, Cheng M, Liu M 2023 Cancer Medicine Oncology Highplex FL HALO
Aberrant gene activation in synovial sarcoma relies on SSX specificity and increased PRC1.1 stability Benabdallah NS, Dalal V, Scott RW, Marcous F, Sotiriou A, Kommoss FKF, Pejkovska A, Gaspar L, Wagner L, Sánchez-Rivera FJ, Ta M, Thornton S, Nielsen TO, Underhill TM, Banito A 2023 Nature Structural & Molecular Biology Oncology Multiplex IHC, TMA HALO, HALO AI
Remodeling Tumor Immune Microenvironment by Using Polymer-Lipid-Manganese Dioxide Nanoparticles with Radiation Therapy to Boost Immune Response of Castration-Resistant Prostate Cancer Zetrini AE, Lip H, Abbasi AZ, Alradwan I, Ahmed T, He C, Henderson JT, Rauth AM, Wu XY 2023 Research Immuno-oncology, Biomaterials Highplex FL HALO
Effects and Mechanisms of the Subtypes of Apolipoprotein E to the Immune State and Prognosis of hepatocellular carcinoma patients Gao B, Zhou P, Wang L, Wang Z, Yi Y, Zhou J, Fan J, Qiu S, Xu Y 2023 Research Square Immuno-oncology Multiplex IHC, Highplex FL HALO
Size and depth of residual tumor after neoadjuvant chemoradiotherapy in rectal cancer – implications for the development of new imaging modalities for response assessment van der Stel SD, van den Berg JG, Snaebjornsson PS, Seignette IM, Witteveen M, Grotenhuis BA, Beets GL, Post AL, Ruers TJM 2023 Frontiers in Oncology Oncology HALO, HALO AI
Regional and cellular iron deposition patterns predict clinical subtypes of multiple system atrophy Lee S, Martinez-Valbuena I, Lang AE, Kovacs GG 2023 Research Square Neuroscience Area Quantification, Object Colocalization HALO
ABCC2 brush-border expression predicts outcome in papillary renal cell carcinoma: a multi-institutional study of 254 cases Castillo VF, Masoomian M, Trpkov K, Downes M, Brimo F, van der Kwast T, Yousef GM, Zakhary A, Rotondo F, Saad G, Nguyen V, Kidanewold W, Streutker C, Rowsell C, Hamdani M, Saleeb RM 2023 Histopathology Oncology ISH HALO
A novel retinoic acid receptor-γ agonist antagonizes immune checkpoint resistance in lung cancers by altering the tumor immune microenvironment Wei CH, Huang L, Kreh B, Liu X, Tyutyunyk-Massey L, Kawakami M, Chen Z, Shi M, Kozlov S, Chan KC, Andresson T, Carrington M, Vuligonda V, Sanders ME, Horowitz A, Hwu P, Peng W, Dmitrovsky E, Liu X 2023 Scientific Reports Immuno-oncology Area Quantification, Cytonuclear HALO, HALO AI
Single-cell RNA-sequencing reveals heterogeneity and intercellular crosstalk in human tuberculosis lung Wang, H, Wen, Z, Niu, L, Chen, X, Liu, H, Zhang, S, Xu, J, Zhu, Y, Li, H, Chen, H, Shi, L, Wan, L, Li, L, Li, M, Wong, K, Song, Y 2023 Journal of Infection Immunology, Infectious Disease Spatial Analysis, Highplex FL HALO
Gys1 Antisense Therapy Prevents Disease-Driving Aggregates and Epileptiform Discharges in a Lafora Disease Mouse Model Donohue K, Fitzsimmons B, Bruntz R, Markussen K, Young L, Clarke H, Coburn P, Griffith L, Sanders W, Klier J, Burke S, Maurer A, Minassian B, Sun R, Kordasiewisz H, Gentry M 2023 Neurotherapeutics Neuroscience Area Quantification HALO
Single-cell analysis of the miRNA activities in tuberculous meningitis (TBM) model mice injected with the BCG vaccine Zhang X, Pan L, Zhang P, Wang L, Shen Y, Xu P, Ren Y, Huang W, Liu P, Wu Q, Li F 2023 International Immunopharmacology Infectious Disease FISH HALO
An immune cell atlas reveals the dynamics of human macrophage specification during prenatal development Wang Z, Wu Z, Wang H, Feng R, Wang G, Li M, Wang S, Chen X, Su Y, Wang J, Zhang W, Bao Y, Lan Z, Song Z, Wang Y, Luo X, Zhao L, Hou A, Tian S, Gao H, Miao W, Liu Y, Wang H, Yin C, Ji Z, Feng M, Liu H, Diao L, Amit I, Chen Y, Zeng Y, Ginhoux F, Wu X, Zhu Y, Li H 2023 Cell Immunology Highplex FL HALO
The prognostic value of CD39 +CD8 + T cells as a potential surrogate marker of tumor-specific T cells in Asian triple-negative breast cancer Meng J, Tira TJY, Joseph CR, Ye J, Lim JCT, Goh D, Yuezhen X, Lim X, Koh VCY, Wee F, Tay TKY, Chan JV, Ng CCY, Iqbal J, Lau MC, Elaine LH, Chong TH, The BT, Dent RA, Tan PH, Sheng JYP 2023 Research Square Immuno-oncology Highplex FL HALO
Osteoprogenitor recruitment and differentiation during intracortical bone remodeling of adolescent humans Christiansen PvD, Andreasen CM, El-Masri BM, Laursen KS, Delaisse JM, Andersen TL 2023 Bone Other FISH HALO, HALO AI
HER2-Selective and Reversible Tyrosine Kinase Inhibitor Tucatinib Potentiates the Activity of T-DM1 in Preclinical Models of HER2-positive Breast Cancer  Olson D, Taylor J, Willis K, Hensley K, Allred S, Zaval M, Farr L, Thurman R, Jain N, Hein R, Ulrich M, Peterson S, Kulukian A 2023 Cancer Research Communications Oncology Classifier, Multiplex IHC HALO
Tumor-associated macrophages trigger MAIT cell dysfunction at the HCC invasive margin Ruf B, Bruhns M, Babaei S, Kedei N, Ma L, Revsine M, Benmebarek MR, Ma C, Heinrich B, Subramanyam V, Qi J, Wabitsch S, Green BL, Bauer KC, Myojin Y, Greten LT, McCallen JD, Huang P, Trehan R, Wang X, Nur A, Soika DQM, Pouzolles M, Evans CN, Chari R, Kleiner DE, Telford W, Dadkhah K, Ruchinskas A, Stovroff MK, Kang J, Oza K, Ruchirawat M, Kroemer A, Wang XW, Claassen M, Korangy F, Greten TF 2023 Cell Immuno-oncology Classifier, Spatial Analysis, Highplex FL, Figure Maker HALO
Parvalbumin in the metabolic pathway of glutamate and γ-aminobutyric acid: Influence on expression of GAD65 and GAD67 Zeng C, Lei D, Lu Y, Huang Q, Wu Y, Yang S, Wu Y 2023 Archives of Biochemistry and Biophysics Neuroscience Area Quantification HALO
Icariside II potentiates the anti-PD-1 antitumor effect by reducing chemotactic infiltration of myeloid-derived suppressor cells into the tumor microenvironment via ROS-mediated inactivation of the SRC/ERK/STAT3 signaling pathways Kong Q, Ma M, Zhang L, Liu S, He S, Wu J, Liu B, Dong J 2023 Phytomedicine Immuno-oncology Multiplex IHC HALO
Comprehensive analysis of immune subtypes reveals the prognostic value of cytotoxicity and FAP+ fibroblasts in stomach adenocarcinoma Wang X, Hui S, Tan C, Deng Z, Wang X, Weng W, Zhang M, Ni S, Wang L, Huang D, Wang W, Xu M, Sheng W 2023 Cancer Immunology, Immunotherapy Immuno-oncology Highplex FL HALO
Tumor cell HLA class I expression and pathologic response following neoadjuvant immunotherapy for newly diagnosed head and neck cancer Robbins Y, Friedman J, Redman J, Sievers C, Lassoued W, Gulley J, Allen C 2023 Oral Oncology Immuno-oncology Classifier, Spatial Analysis, Highplex FL HALO
Establishment of reference intervals of endometrial immune cells during the mid-luteal phase Yu S, Huang C, Lian R, Diao L, Zhang X, Cai S, Wei H, Chen C, Li Y, Zeng Y 2023 Journal of Reproductive Immunology Immunology Classifier, Multiplex IHC HALO
A phase I, first-in-human study of TAK-164, an antibody–drug conjugate, in patients with advanced gastrointestinal cancers expressing guanylyl cyclase C Kim R, Leal A, Parikh A, Ryan D, Wang S, Bahamon B, Gupta N, Moss A, Pye J, Miao H, Inguilizian H, Cleary J 2023 Cancer Chemotherapy and Pharmacology Oncology Area Quantification HALO
Anticoagulants Enhance Molecular and Cellular Immunotherapy of Cancer by Improving Tumor Microcirculation Structure and Function and Redistributing Tumor Infiltrates Wei F, Su Y, Quan Y, Li X, Zou Q, Zhang L, Li S, Jiang M, Lin G, Liang P, He J, Xie K 2023 Clinical Cancer Research Immuno-oncology Classifier, Multiplex IHC, Spatial Analysis, Highplex FL HALO
Apolipoprotein A-IV of diabetic-foot patients upregulates tumor necrosis factor α expression in microfluidic arterial models Ji J, Zhao X, Huang J, Wu X, Xie F, Li L, Wang T, Mi S 2023 Experimental Biology and Medicine Other Multiplex IHC HALO
Characterization of expression and prognostic implications of transforming growth factor beta, programmed death-ligand 1, and T regulatory cells in canine histiocytic sarcoma Murphy J, Shiomitsu K, Milner R, Lejeune A, Ossiboff R, Gell J, Axiak-Bechtel S 2023 Veterinary Immunology and Immunopathology Oncology ISH HALO
Baseline skin cytokine profiles determined by RNA in situ hybridization correlate with response to dupilumab in patients with eczematous dermatitis Singh K, Valido K, Swallow M, Okifo K, Wang A, Cohen J, Damsky W 2023 Journal of the American Academy of Dermatology Dermatology ISH HALO
FGF18 promotes human lung branching morphogenesis through regulating mesenchymal progenitor cells Danopoulos S, Belgacemi R, Hein R, Miller A, Deutsch G, Glass I, Spence J, Al Alam D 2023 American Journal of Physiology - Lung Cellular and Molecular Physiology Other FISH HALO
A Spatial Atlas of Wnt Receptors in Adult Mouse Liver Gayden J, Hu S, Joseph P, Delgado E, Liu S, Bell A, Puig S, Monga S, Freyberg Z 2023 The American Journal of Pathology Gastroenterology FISH HALO
Combination IFNβ and membrane-stable CD40L maximize tumor dendritic cell activation and lymph node trafficking to elicit systemic T-cell immunity Zheng H, Yu X, Ibrahim M, Foresman D, Xie M, Johnson J, Boyle T, Ruffell B, Perez B, Antonia S, Ready N, Saltos A, Cantwell M, Beg A 2023 Cancer Immunology Research Immuno-oncology Highplex FL HALO
Novel read through agent: ZKN-0013 demonstrates efficacy in APCmin model of familial adenomatous polyposis Graf M, Apte S, Terzo E, Padhye S, Shi S, Cox M, Clark R, Modur V, Badarinarayana V 2023 Journal of Molecular Medicine Oncology Area Quantification HALO
Key Residue in the Precursor Region of M Protein Contributes to the Neurovirulence and Neuroinvasiveness of the African Lineage of Zika Virus He M, Wang H, Yan X, Lou Y, Song G, Li R, Zhu Z, Zhang R, Qin C, Li X 2023 Journal of Virology Infectious Disease Highplex FL HALO
Mitochondria-localized cGAS suppresses ferroptosis to promote cancer progression Qiu S, Zhong X, Meng X, Li S, Qian X, Lu H, Cai J, Zhang Y, Wang M, Ye Z, Zhang H, Gao P 2023 Cell Research Oncology Multiplex IHC HALO
Apolipoprotein E induces pathogenic senescent-like myeloid cells in prostate cancer Bancaro N, Cali B, Troiani M, Elia A, Arzola R, Attanasio G, Lai P, Crespo M, Gurel B, Pereira R, Guo C, Mosole S, Brina D, D'Ambrosio M, Pasquini E, Spataro C, Zagato E, Rinaldi A, Pedotti M, Lascio S, Meani F, Montopoli M, Ferrari M, Gallina A, Varani L, Mestre R, Bolis M, Sommer S, de Bono J, Calcinotto A, Alimonti A 2023 Cancer Cell Oncology Classifier, Highplex FL HALO
Acute Influenza Infection Promotes Lung Tumor Growth by Reprogramming the Tumor Microenvironment Garmendia I, Varthaman A, Marmier S, Angrini M, Matchoua I, Darbois-Delahousse A, Josseaume N, Foy P, Roumenina L, Naouar N, Meylan M, Siberil S, Russick J, Joubert P, Leroy K, Damotte D, Mansuet-Lupo A, Wislez M, Alifano M, Menger L, Garcia-Verdugo I, Sallenave J, Lantz O, Petitprez F, Cremer I 2023 Cancer Immunology Research Oncology, Infectious Disease Highplex FL HALO
p38MAPKa stromal reprogramming sensitizes metastatic breast cancer to immunotherapy Faget D, Luo X, Inkman M, Ren Q, Su X, Ding K, Waters M, Raut G, Pandey G, Dodhiawala P, Ramalho-Oliveira R, Ye J, Cole T, Murali B, Zheleznyak A, Shokeen M, Weiss K, Monahan J, DeSelm C, Lee A, Oesterreich S, Weilbaecher K, Zhang J, DeNardo D, Stewart S 2023 Cancer Discovery Immuno-oncology Area Quantification HALO
Lymph Node Metastases in Papillary Thyroid Carcinoma can be Predicted by a Convolutional Neural Network: a Multi-Institution Study Esce A, Redemann J, Olson G, Hanson J, Agarwal S, Yenwongfai L, Ferreira J, Boyd N, Bocklage T, Martin D 2023 Annals of Otology, Rhinology & Laryngology Oncology HALO, HALO AI
Vascular-Parenchymal Crosstalk Promotes Lung Fibrosis Through BMPR2 Signaling Yanagihara T, Tsubouchi K, Zhou Q, Chong M, Otsubo K, Isshiki T, Schupp J, Sato S, Scallan C, Upagupta C, Revill S, Ayoub A, Chong S, Dvorkin-Gheva A, Kaminski N, Tikkanen J, Keshavjee S, Pare G, Guignabert C, Ask K, Kolb M 2023 American Journal of Respiratory and Critical Care Medicine Fibrosis Area Quantification, ISH, TMA HALO
Spatial mapping reveals granuloma diversity and histopathological superstructure in human tuberculosis Sawyer A, Patrick E, Edwards J, Wilmott J, Fielder T, Yang Q, Barber D, Ernst J, Britton W, Palendira U, Chen X, Feng C 2023 Journal of Experimental Medicine Immunology Multiplex IHC, Spatial Analysis, Highplex FL HALO
Intrinsic BMP inhibitor Gremlin regulates alveolar epithelial type II cell proliferation and differentiation Yanagihara T, Zhou Q, Tsubouchi K, Revill S, Ayoub A, Gholiof M, Chong S, Dvorkin-Gheva A, Ask K, Shi W, Kolb M 2023 Biochemical and Biophysical Research Communications Other ISH, TMA HALO
Secreted mammalian DNases protect against systemic bacterial infection by digesting biofilms Lacey K, Serpas L, Makita S, Wang Y, Rashidfarrokhi A, Soni C, Gonzalez S, Moreira A, Torres V, Reizis B 2023 Journal of Experimental Medicine Infectious Disease HALO, HALO AI
Measurement of ovarian tumor immune profiles by multiplex immunohistochemistry: implications for epidemiologic studies Hathaway C, Conejo-Garcia J, Fridley B, Rosner B, Saeed-Vafa D, Segura C, Nguyen J, Hecht J, Sasamoto N, Terry K, Tworoger S, Townsend M 2023 Cancer Epidemiology, Biomarkers & Prevention Immuno-oncology Highplex FL HALO
New insight on the correlation of immune landscapes with immune markers expression in different risk classification of gastrointestinal stromal tumors Zhang Q, Sun X, Hou Y, Gao X, Shen K, Qin X 2023 Journal of Gastroenterology Immuno-oncology Highplex FL HALO
Therapeutic neutralizing monoclonal antibody administration protects against lethal yellow fever virus infection RICCIARDI M, RUST L, PEDREÑO-LOPEZ N, YUSOVA S, BISWAS S, WEBB G, GONZALEZ-NIETO L, VOIGT T, LOUW J, LAURINO F, DIBELLO J, RAUÉ H, BARBER-AXTHELM A, CHUN K, UTTKE S, RAPHAEL L, YRIZARRY-MEDINA A, ROSEN B, AGNOR R, GAO L, LABRIOLA C, AXTHELM M, SMEDLEY J, JULANDER J, BONALDO M, WALKER L, MESSAOUDI I, SLIFKA M, BURTON D, KALLAS E, SACHA J, WATKINS D, BURWITZ B 2023 Science Translational Medicine infectious Disease HALO, HALO Link
Lineage tracing reveals clonal progenitors and long-term persistence of tumor-specific T cells during immune checkpoint blockade Pai J, Hellmann M, Sauter J, Mattar M, Rizvi H, Woo H, Shah N, Nguyen E, Uddin F, Quintanal-Villalonga A, Chan J, Manoj P, Allaj V, Baine M, Bhanot U, Jain M, Linkov I, Meng F, Brown D, Chaft J, Plodkowski A, Gigoux M, Won H, Sen T, Wells D, Donoghue M, Stanchina E, Wolchok J, Loomis B, Merghoub T, Rudin C, Chow A, Satpathy A 2023 Cancer Cell Immuno-oncology Classifier HALO
T cell immunotherapies engage neutrophils to eliminate tumor antigen escape variants Hirschhorn D, Budhu S, Kraehenbuehl L, Gigoux M, Schröder D, Chow A, Ricca J, Gasmi B, De Henau O, Mangarin L, Li Y, Hamadene L, Flamar A, Choi H, Cortez C, Liu C, Holland A, Schad S, Schulze I, Warner A, Hollmann T, Arora A, Panageas K, Rizzuto G, Duhen R, Weinberg A, Spencer C, Ng D, He X, Albrengues J, Redmond D, Egeblad M, Wolchok J, Merghoub T 2023 Cell Area Quantification, Highplex FL HALO
Plaque Macrophage-Targeting Nanosystems with Cooperative Co-Regulation of ROS and TRAF6 for Stabilization of Atherosclerotic Plaques Yang Q, Jiang H, Wang Y, Leng X, Wang Y, Tong J, Zhou Y, Mo C, Peng J, Gao H 2023 Advanced Functional Materials Biomaterials Highplex FL HALO
Characterization of expression and prognostic implications of GD2 and GD3 synthase in canine histiocytic sarcoma Murphy J, Axiak-Bechtel S, Milner R, Lejeune A, Ossiboff R, Castellanos Gell J, Shiomitsu K 2023 Veterinary Immunology and Immunopathology Oncology ISH HALO
Functional specialization of short-lived and long-lived macrophage subsets in human tonsils Alaoui L, Villar J, Leclere R, Le Gallou S, Relouzat F, Michaud H, Tarte K, Teissier N, Favier B, Roussel M, Segura E 2023 Journal of Experimental Medicine Immunology Highplex FL HALO
Increased Nerve Density Adversely Affects Outcome in Oral Cancer Perez-Pacheco C, Schmitd L, Furgal A, Bellile E, Liu M, Fattah A, Gonzalez-Maldonado L, Unsworth S, Wong S, Rozek L, Rao A, Wolf G, Taylor J, Casper K, Mierzwa M, D'Silva N 2023 Clinical Cancer Research Oncology HALO, HALO AI
Targeting the IL1β Pathway for Cancer Immunotherapy Remodels the Tumor Microenvironment and Enhances Antitumor Immune Responses Diwanji R, O'Brien N, Choi J, Nguyen B, Laszewski T, Grauel A, Yan Z, Xu X, Wu J, Ruddy D, Piquet M, Pelletier M, Savchenko A, Charette L, Rodrik-Outmezguine V, Baum J, Millholland J, Wong C, Martin A, Dranoff G, Pruteanu-Malinici I, Cremasco V, Sabatos-Peyton C, Jayaraman P 2023 Cancer Immunology Research Immuno-oncology Multiplex IHC HALO
Spinal Cord Stimulation Increases Chemoefficacy and Prevents Paclitaxel-Induced Pain via CX3CL1 Sivanesan E, Sanchez K, Zhang C, He S, Linderoth B, Stephens K, Raja S, Guan Y 2023 Neuromodulation: Technology at the Neural Interface Oncology Multiplex IHC HALO
An immunogenic and oncogenic feature-based classification for chemotherapy plus PD-1 blockade in advanced esophageal squamous cell carcinoma Chen Y, Wang Z, Jin Y, Zhao Q, Liu Z, Zuo Z, Ju H, Cui C, Yao J, Zhang Y, Li M, Feng J, Tian L, Xia X, Feng H, Yao S, Wang F, Li Y, Wang F, Xu R 2023 Cancer Cell Immuno-oncology Cytonuclear HALO
DNA Damage-Induced, S-Phase Specific Phosphorylation of Orc6 is Critical for the Maintenance of Genome Stability Lin Y, Liu D, Chakraborty A, Macias V, Brister E, Sonalkar J, Shen L, Mitra J, Ha T, Kajdacsy-Balla A, Prasanth K, Prasanth S 2023 Molecular and cellular biology Other Multiplex IHC HALO, HALO AI
Coptisine modulates the pharmacokinetics of florfenicol by targeting CYP1A2, CYP2C11 and CYP3A1 in the liver and P-gp in the jejunum of rats: a pilot study Li S, Zhang M, Wang B, Li X, Liang G 2023 Xenobiotica Gastroenterology Area Quantification HALO
Phase I Study of SYNB1891, an Engineered E. coli Nissle Strain Expressing STING Agonist, with and without Atezolizumab in Advanced Malignancies Luke J, Piha-Paul S, Medina T, Verschraegen C, Varterasian M, Brennan A, Rise R, Sokolovska A, Strauss J, Hava D, Janku F 2023 Clinical Cancer Research Immuno-oncology Area Quantification
Hepatic proinflammatory myeloid phenotypes are a hallmark of Ebola virus Kikwit pathogenesis in rhesus monkeys Tseng A, Carossino M, Gertje H, O'Connell A, Gummuluru S, Kolachalama V, Balasuriya U, Connor J, Bennett R, Liu D, Hensley L, Crossland N 2023 Veterinary Pathology Infectious Disease Area Quantification, Highplex FL HALO
Using artificial intelligence to identify tumor microenvironment heterogeneity in non-small cell lung cancers DuCote T, Naughton K, Skaggs E, Bocklage T, Allison D, Brainson C 2023 Laboratory Investigation Oncology Multiplex IHC HALO, HALO AI
Whole-Slide Imaging, Mutual Information Registration for Multiplex Immunohistochemistry and Immunofluorescence Doyle J, Green B, Eminizer M, Jimenez-Sanchez D, Lu S, Engle E, Xu H, Ogurtsova A, Lai J, Soto-Diaz S, Roskes J, Deutsch J, Taube J, Sunshine J, Szalay A 2023 Laboratory Investigation Other Multiplex IHC, Registration HALO
Impact of second opinion pathology review in the diagnosis and management of atypical melanocytic lesions: A prospective study of the Italian Melanoma Intergroup (IMI) and EORTC Melanoma Group Massi D, Szumera-Ciećkiewicz A, Alos L, Simi S, Ugolini F, Palmieri G, Stanganelli I, Cook M, Mandalà M 2023 European Journal of Cancer Oncology HALO, HALO Link
Inhibiting membrane rupture with NINJ1 antibodies limits tissue injury Kayagaki N, Stowe I, Alegre K, Deshpande I, Wu S, Lin Z, Kornfeld O, Lee B, Zhang J, Liu J, Suto E, Lee W, Schneider K, Lin W, Seshasayee D, Bhangale T, Chalouni C, Johnson M, Joshi P, Mossemann J, Zhao S, Ali D, Goldenberg N, Sayed B, Steinberg B, Newton K, Webster J, Kelly R, Dixit V 2023 Nature Other Multiplex IHC HALO, HALO AI
Nicotinamide N-methyltransferase sustains a core epigenetic program that promotes metastatic colonization in breast cancer Pinto Couto J, Vulin M, Jehanno C, Coissieux M, Hamelin B, Schmidt A, Ivanek R, Sethi A, Bräutigam K, Frei A, Hager C, Manivannan M, Gómez-Miragaya J, Obradović M, Varga Z, Koelzer V, Mertz K, Bentires-Alj M 2023 The EMBO Journal Oncology Area Quantification, Multiplex IHC HALO, HALO AI
Circulating and intratumoral immune determinants of response to atezolizumab plus bevacizumab in patients with variant histology or sarcomatoid renal cell carcinoma Saliby R, Zarif T, Bakouny Z, Shah V, Xie W, Flippot R, Denize T, Kane M, Madsen K, Ficial M, Hirsch L, Wei X, Steinarter J, Harshman L, Vaishampayan U, Severgnini M, McDermott D, Lee G, Xu W, Van Allen E, McGregor B, Signoretti S, Choueiri T, McKay R, Braun D 2023 Cancer Immunology Research Immuno-oncology Highplex FL HALO
The tumor immune microenvironment of nasopharyngeal carcinoma after gemcitabine plus cisplatin treatment Lv J, Wei Y, Yin J, Chen Y, Zhou G, Wei C, Liang X, Zhang Y, Zhang C, He S, He Q, Huang Z, Guan J, Shen J, Li X, Li J, Li W, Tang L, Mao Y, Guo R, Sun R, Zheng Y, Zhou W, Xiong K, Wang S, Jin X, Liu N, Li G, Kuang D, Sun Y, Ma J 2023 Nature Medicine Oncology Multiplex IHC, Highplex FL HALO
Effect of Dupilumab on Type 2 Biomarkers in Chronic Rhinosinusitis With Nasal Polyps: SINUS-52 Study Results Bachert C, Laidlaw T, Cho S, Mullol J, Swanson B, Naimi S, Classe M, Harel S, Jagerschmidt A, Laws E, Ruddy M, Praestgaard A, Amin N, Mannent L 2023 Annals of Otology, Rhinology & Laryngology Other Area Quantification HALO, HALO AI
Bavituximab decreases immunosuppressive myeloid-derived suppressor cells in newly diagnosed glioblastoma patients Ly K, Richardson L, Liu M, Muzikansky A, Cardona J, Lou K, Beers A, Chang K, Brown J, Ma X, Reardon D, Arrillaga-Romany I, Forst D, Jordan J, Lee E, Dietrich J, Nayak L, Wen P, Chukwueke U, Giobbie-Hurder A, Choi B, Batchelor T, Kalpathy-Cramer J, Curry W, Gerstner E 2023 Clinical Cancer Research Immuno-oncology Highplex FL HALO
Immune profiling and RNA-seq uncover the cause of partial unexplained recurrent implantation failure Fan X, Zhao Q, Li Y, Chen Z, Liao J, Chen H, Meng F, Lu G, Lin G, Gong F 2023 International Immunopharmacology Immunology Classifier, Multiplex IHC HALO
Targeting the ATF6-mediated ER stress response and autophagy blocks integrin-driven prostate cancer progression Macke A, Pachikov A, Divita T, Morris M, LaGrange C, Holzapfel M, Kubyshkin A, Zyablitskaya E, Makalish T, Eremenko S, Qiu H, Riethoven J, Hemstreet G, Petrosyan A 2023 Molecular Cancer Research Oncology Classifier, Area Quantification, Multiplex IHC, TMA HALO
Comparing the peri-implantation endometrial T-bet/GATA3 ratio between control fertile women and patients with recurrent miscarriage: establishment and application of a reference range Get access Arrow Yu S, Diao L, Lian R, Chen C, Huang C, Li X, Li Y, Zeng Y 2023 Human Reproduction Other Classifier, Multiplex IHC HALO
Combined CDK4/6 and ERK1/2 inhibition enhances anti-tumor activity in NF1-associated plexiform neurofibroma Flint AC, Mitchell DK, Angus SP, Smith AE, Bessler W, Jiang L, Mang H, Li X, Lu Q, Rodriguez B, Sandusky GE, Masters AR, Zhang C, Dang P, Koenig J, Johnson GL, Shen W, Liu J, Aggarwal A, Donoho GP, Willard MD, Bhagwat SV, Clapp DW, Rhodes SD 2023 Clinical Cancer Research Neuroscience Cytonuclear HALO
Jing-Fang powder ethyl acetate extracts attenuate atopic dermatitis by modulating T-cell activity Zhao G, Tong Y, Xu J, Zhu W, Zeng J, Liu R, Luan F, Zeng N 2023 Molecular Immunology Immunology, Dermatology Multiplex IHC HALO
Single-cell dissection of cervical cancer reveals key subsets of the tumor immune microenvironment Cao G, Yue J, Ruan Y, Han Y, Zhi Y, Lu J, Liu M, Xu X, Wang J, Gu Q, Wen X, Gao J, Zhang Q, Kang J, Wang C, Li F 2023 The EMBO Journal Immuno-oncology Highplex FL HALO
LY6E is a pan-coronavirus restriction factor in the respiratory tract Mar K, Wells A, Van Dyke M, Lopez A, Eitson J, Fan W, Hanners N, Evers B, Shelton J, Schoggins J 2023 Nature Microbiology Infectious Disease Multiplex IHC HALO
Genetically- and spatially-defined basolateral amygdala neurons control food consumption and social interaction Lim H, Zhang Y, Peters C, Straub T, Mayer JL, Klein R 2023 bioRxiv Neuroscience FISH HALO
Molecular determinants of clinical outcomes of pembrolizumab in recurrent ovarian cancer: Exploratory analysis of KEYNOTE-100 Ledermann JA, Shapira-Frommer R, Santin AD, Lisyanskaya AS, Pignata S, Vergote I, Raspagliesi F, Sonke GS, Birrer M, Provencher DM, Sehouli J, Colombo N, González-Martín A, Oaknin A, Ottevanger PB, Rudaitis V, Kobie J, Nebozhyn M, Edmondson M, Sun Y, Cristescu R, Jelinic P, Keefe SM, Matulonis UA 2023 Gynecologic Oncology Immuno-oncology Classifier, Highplex FL HALO
ASK1 inhibitors are potential pan-antiviral drugs, which dampen replication of diverse viruses including SARS-CoV2 Demian W, Jacob R, Cormier O, Nazli A, Melki M, Asavajaru A, Baid K, Zhang A, Miller M, Kaushic C, Banerjee A, Mossman K 2023 Antiviral Research Infectious Disease Area Quantification HALO
Classification of the tumor immune microenvironment and associations with outcomes in patients with metastatic melanoma treated with immunotherapies Adegoke N, Gide T, Mao Y, Quek C, Patrick E, Carlino M, Lo S, Menzies A, da Silva P, Vergara I, Long G, Scolyer R, Wilmott J 2023 Journal for ImmunoTherapy of Cancer Immuno-oncology Classifier, Highplex FL HALO
The PD-1- and LAG-3-targeting bispecific molecule tebotelimab in solid tumors and hematologic cancers: a phase 1 trial Luke J, Patel R, Blumenschein R, Hamilton E, Chmielowski B, Ulahannan S, Connolly R, Santa-Maria C, Wang J, Bahadur S, Weickhardt A, Asch A, Mallesara G, Clingan P, Dlugosz-Danecka M, Tomaszewska-Kiecana M, Pylypenko H, Hamad N, Kindler H, Sumrow B, Kaminker P, Chen F, Zhang X, Shah K, Smith D, De Costa A, Li J, Li H, Sun J, Moore P 2023 Nature Medicine Immuno-oncology Highplex FL HALO
High-plex spatial transcriptomic profiling reveals distinct immune components and the HLA class I/DNMT3A/CD8 modulatory axis in mismatch repair-deficient endometrial cancer Guo J, Tang B, Fu J, Zhu X, Xie W, Wang N, Ding Z, Song Z, Yang Y, Xu G, Xiao X 2023 Cellular Oncology Immuno-oncology Highplex FL, Figure Maker HALO
Data-driven identification of total RNA expression genes for estimation of RNA abundance in heterogeneous cell types highlighted in brain tissue Huuki-Myers L, Montgomery KD, Kwon SH, Page SC, Hicks SC, Maynard KR, Collado-Torres L 2023 Genome Biology Other FISH-IF HALO
Carcinogen exposure enhances cancer immunogenicity by blocking the development of an immunosuppressive tumor microenvironment Huang M, Xia Y, Li K, Shao F, Feng Z, Li T, Azin M, Demehri S 2023 The Journal of Clinical Investigation Immuno-oncology Highplex FL HALO